<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="https://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCY1</accession>
    <name>A0A8H7PCY1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_008284</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCY1"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17321">
        <property type="entry name" value="MFS_MMR_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="22"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="483"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2171558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="498" mass="53475" checksum="1427AE7A8E00D77A" modified="2022-01-19" version="1">MLNILHEPFLKPTDKKIAKIITLATACFASFLDVLNLSAVNIAVPTIARDIDLTPSTLPWLMAAYSIAFAAFLLPAGKLGDIYGYRMVYLLGLSLFALTSLLNAVSPNQYALFVFRAIQGLAAACVIPTGIALIANICEDEDERRLGFSLFGSSGPIGLVIGIILGGVLSSSIGWRWIFYVSAICSLAMLILAGLFVSDSKNEKTEEKVDMVGFSLVTSGFILIIFALSDGQWHLARDPVTLIIGVLLIIAFLVWQTKTSQPLLHPSWWRRTNFAIAFILNFVNYGSFSGYIYVATLLFQDVFGYTALQTGLYYLPMGIAAFLACNAVGYLTPYMGSRLLVIIGTTIGAAANVGTLFYSTELGFWKLIFPMHLLMGIGQPLTYVAGQNAMLLSAPVHETGTVGAVYNTASQLGSAMGLAIVTAIINAVNAADSHATNAFGGYHAALYALVALEVFCMISGGLFIRDERKNASSNQKIELENGTGASTNSSTVTVQDHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD61</accession>
    <name>A0A8H7PD61_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD61"/>
    <dbReference type="OrthoDB" id="2289482at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034867704" evidence="1">
        <location>
            <begin position="18"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="190" mass="19851" checksum="1A7703A75A16FEA4" modified="2022-01-19" version="1">MKFTALAITALVGAVSADFFSANFVPTKYKEVNTAVLSANYINPTALNEAGLGCGMGNGVLINSIDWLYFNNCTDNVAAHFGLSKDGSSLDYIIKNPKTVYPCVETTTPKNATFTNFVCSDAFNLPSSVTVAYPKTTPFNVSPASSAAKAGATCTAGFSGKKNGNGPTGACCTHSDDCHETCYQGACKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD97</accession>
    <name>A0A8H7PD97_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin fusion degradation protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_008175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD97"/>
    <dbReference type="OrthoDB" id="422728at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.50:FF:000001">
        <property type="entry name" value="Ubiquitin fusion degradation protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="5">
        <location>
            <begin position="7"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="6">
        <location>
            <begin position="108"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="285"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00074895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2171795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="325" mass="35638" checksum="A1C4748652DBF5DE" modified="2022-01-19" version="1" fragment="single">MNPNRGFSEMYRCYSIAMMQSGSDRDNVSYGGKIILPQSALEKLSRLNISYPMLFKLINAERGVHTHAGVLEFIAEEGRAYLPHWMMQALQVEQGEIIEIKNTTLPLGTFVRIQPQSVDFLDISDPKAVLENAFRNFATLTQGDIIQIIYNNKIYEIKVLEIKPSYDDHGGISIMETDLEVDFAPPVGYVEPSAAPRSIPMGSKMIIDEPQTKPANAPFQGSGQTLKSRAKDLLKDSPNSSTTSLSDAVAESAAIQHEDNAIPAPLNLPFGQLYFGYPVVPLKSAEEKENEVKQSFSGAGQTLRAARKAQSRQGSGTSSPAPQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDP0</accession>
    <name>A0A8H7PDP0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_001480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDP0"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF2">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="507"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="5">
        <location>
            <begin position="896"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1244"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2172003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1264" mass="144952" checksum="93820F15BCE5C44C" modified="2022-01-19" version="1">MTSHLAHKPDPPSHDLLPPTPTSLYNQKLTFSMPTTPPPLPPPHANTANTIDQETWNRLNLNYKPANYNLNLPQQRSSDSDGPPKELRFPYSQAQPPPGGLEYAWEQKYGLVTPANSQQQQPAVFRQSAPSGYFARHDSRPLLPSERYDRRSFVMPTERYRQIPRLSSNNNQYVLPPLDRYHNREPPSPPHYAPAHRDTRIASLPQLPSESRTSQQSGGGYHSRDSEDQTPAYQPIQPSDQQPRLQERYSENQLSIVPDGPNHAQRSQSVSYGSMFNQVKQDRDRHKEHELFLSKGTPLVYPGLLSLVAQEFKRQVEVGTRIKDGLEYKNVFDGRQAVTKLSLIICTNNRKLALRLGRALEFQKLFHDVSYEHRLLDSDHELYQFHDHVMHITSYRETDLDMTGKEEIPDEKYEESESSFEVNYDEPVSGVYTELTNCYSPTCTGSRPCYSRSCPKRFIQNHVEDSGYRSSLNRSVSATLSHTPPQELWVNQVSSTIVDSLTKQDRKRQENIFELIYTEKNFVTDIEYVYQMWIVPLLTTDAIPSSRRDHFVHTVFSNITAIHEVNSRLLFALQKRQSEHPVVSQIGDVMLAHVVNFEPFVEYGARQYGAKMAFERERAVNQEFDAFIKEVERKPESRKLEINGYLTKPTTRLGRYNLLLGEILKNTPEGHSDCVAIKKAMDIITKFLRRVNIESGNAKNKFDLRQLHDNMSFKNKSDDTNLDLLAEERLIIKQGSLKKTAALDSTNYQLILLDNYLLITKLKVVGLEEHYTVQRKPIPLELLMVGVPEQTRVRRASSILPYARPGSAIPNVNLSVNAPVWPTVTDVGGYTSNKGGFPISFHHVGRKGSGHFTLYAPTLAARRPWIDKIEKQKELFMKNRRIFELVHICDRLFCLTNRVNHSVSFDNGRYFLLAADQGVYLARAGDIAPPRRILHLDHCTQVQVIEETFTVLVVADRVLWEFPFDILHTKHGEKPDAGRKLRNHTSFIFVGECLNKKLICIPKSSTLNSYVSTYEPTLPREIKKKSAFGRTKNQHEVGLRFFKEIYIPGEAWSVDLSPTKMFITCQRGVQLVDMRTTNTQALLDPNDPDLAFILDRERPDSGLNIRTGVKHICTYRIDAAEHLVCYDEYAFYIDGKGRRKRTGFLIEWEGQPESFAFHYPYVLAFEPSFIEVRHMLTGELEQIIPGIDMMSLLPSMRKGTIRGAMTDSHNDVYRVLFELKSLVNPNENKNAPSQLQSLAYRQTNQVNHSPPSHHTWNTSRNLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PE48</accession>
    <name>A0A8H7PE48_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PE48"/>
    <dbReference type="OrthoDB" id="10394062at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034921795" evidence="1">
        <location>
            <begin position="20"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="124" mass="12794" checksum="ED2744FC26FC0575" modified="2022-01-19" version="1">MKFTLTALLLANAIAISYARCNIALVSPAKSSVGQFNNRGSGCSTAQLAGLKCKSSSSITNTDGNEDVRQYVCASNADYASDYATLRARGIFWGVEGATPAFGTCNAGGVTTCPPVTLCGRKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEE3</accession>
    <name>A0A8H7PEE3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA replication regulator Sld3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_004939</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEE3"/>
    <dbReference type="OrthoDB" id="2144998at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013948">
        <property type="entry name" value="DNA_replication_reg_Sld3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053919">
        <property type="entry name" value="Treslin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08639">
        <property type="entry name" value="Sld3_STD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21854">
        <property type="entry name" value="Treslin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Treslin N-terminal" evidence="3">
        <location>
            <begin position="18"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication regulator Sld3 C-terminal" evidence="2">
        <location>
            <begin position="727"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="861"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="957"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2172397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1128" mass="128415" checksum="A18058970B2545B7" modified="2022-01-19" version="1">MVEGAHSPSSRRKSPPHVVFMVDTHMTSSADLPHRDQAARIRFGILRILLYFHTCVDRRMTWGYQFFDSENSSSTLRMQNHFQELSTSSLDAFLKALNGEIDISSQRQLDKAMNTNDNETPFTRLKQALVQAQSDFQWTEIDFAYLASPGRLRRTPRSMRQMKNGPVEIRNHIYIVSSIPQTYNDIMWYFQSRSESAVQTHLTREGDKMTIVKLMDNVAMELKKTLWEGFVDHRISLNWVDIGDLKLDESLPEDKVNKLFGVLFVCIDDVLIFDQDVREFIGLAFHAIAQIFGGHLIPLTILQPELTEQFGYSVQSILNHYTSKTINTSNDFVRSKKVATNMNKPTLLDEIQKYQMECKESWRGELILGDEHTTNEDQLPIKFRLLVHNFLRSQWSHTLVDLSDTKVGNSPSIEHTFANISSMTVFLQLPVAAIPLKWYQTTEDTKRKTTNKNLFLCTLEHTEDMKMMIEFETLLSKLNDNQYVLIVRLEYRDSAETSCKYAAIEPIAYSSATLGFLDCEAEDLLACAMFHTSVDPYHRMYGSNLFDPWARESFEDNAEEHFQLYEIECDLPKELEVAIVADSDLQSTTAREGESAIITAIEALNTDNPVASLEIDVKEDKPDSLEELQSTWISLYLQSLYLSTIEPEAIARQFQLWVSHLEHNMYIQVSTVHGGGTGCVPSRNGDLLSRNDELLSLTDELAKHLVEDEDQVLEKWKKIRPLDTKILRMIKIKDAQLQIIVMLKIMELEKRFMTLNKIELPKPQKKRKKKKKLSAEDFEQQLELYFDRLCIWDSMMDITNVTETSKANVGKNGPESSAMNLKTLCKNLSDIYRPILPDIIDKLWSRCGGEEEPLQLEMDRSLSAGSAKDSAPEKGTVRTSRSKPMDMDARVKLLESRIRGPSTETMVTDAIWATQSDKKVAQQPSASISLLSGTRRHTASTINLPFMKREIEMTKSLNVSSKTKHAASTSAPSRTTGSRRKIAVPRKITMAVTGGENTETVVLRKRQVFSPTTPRTRAERDFGLRLARTPTNAPLDVPTAAKRSTETIDGPVTSSPRKLMRTFSGSRSPSAQRHKSLPMSRMRLSPNSPSHNRIKQTRPTDLSSIMPKRDLFSSFLQASGSEEDQNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEI3</accession>
    <name>A0A8H7PEI3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEI3"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2172423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="90" mass="10468" checksum="2B52C20C056D3F60" modified="2022-01-19" version="1">MEDLSQRPNVLQYPYELWSTGFDRKHPSSELALNPWYGCLQADFLQHISYRRHQMSEKEKHVLLGHVGDFVPEDDLVTAEEKLLKVLGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEQ8</accession>
    <name>A0A8H7PEQ8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">5-aminolevulinate synthase</fullName>
            <ecNumber evidence="11">2.3.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">5-aminolevulinic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Delta-ALA synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Delta-aminolevulinate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_004857</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="2.3.1.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.37" evidence="11"/>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEQ8"/>
    <dbReference type="OrthoDB" id="10263824at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003870">
        <property type="term" value="F:5-aminolevulinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010961">
        <property type="entry name" value="4pyrrol_synth_NH2levulA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01821">
        <property type="entry name" value="5aminolev_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="148"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU910713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2172315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="567" mass="61239" checksum="1690D1FB4EA23D60" modified="2022-01-19" version="1" fragment="single">FFFFSTMERVLNTAQKACPFLHNASAATIRGLSAKAPSGATNTKLMTKAQQCPVMGKAIAVQTSRFHTASKAAAPAPTAPRAILSNEPKKAAVAPVSHNTSGNKFDYESFYNHHLEKKHKDKSYRYFNNINRLAQKFPRAHTARPEDEVTVWCANDYLGMGRSPVLIDSMKRTLDRYGAGAGGTRNIAGNADLHLRLESELADLHHTEGALVFSSCYVANDATLATLAGKLPGCVIFSDSQNHASMIQGIRHSGAQKKIFRHNDLAHLEELLQSVDVSVPKIVAFESVYSMCGSIGPIKEICQLAKKYGAITFLDEVHAVGMYGPRGAGVAEHLDFELNATQPHGGNGSVMDMVDIYTGTLGKAFGVVGGYIAGSAALVDMVRSYAPGFIFTTSLPPAVVSGAMESVKYLKRSAAERTKQQVNTRIVKDRLASLEIPVIPNPSHIVPVLLGDAEQAKLASDTLLSEFGIYVQSINYPTVSVGEERLRITPTPGHNTEMIDHLVDSLDKIWTRNNFKRVKQWEAEGGRAGVGCANANAVEPIWTDKQLQLGKVTEATSQTLASASASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEV5</accession>
    <name>A0A8H7PEV5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein eL24-related N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_004911</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEV5"/>
    <dbReference type="OrthoDB" id="1727108at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL24-related N-terminal" evidence="5">
        <location>
            <begin position="17"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2172369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="142" mass="15900" checksum="6BA5A4AC4482BAF5" modified="2022-01-19" version="1">MLLHSPGLKSAPSLVTRSTLSFRFMNGKCESYFLQRLNPRKINWTVVYRRMHKKGITEEVAKKRSRRTVKHDRAVVGASWDAIRAKRAQKPEVRAAARQAAVAKSKEAKKAKAASSKANPQQPKMSKQQAKGFAPKAQATSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEX8</accession>
    <name>A0A8H7PEX8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pex19 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEX8"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033328">
        <property type="term" value="F:peroxisome membrane targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.900">
        <property type="entry name" value="Pex19, mPTS binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006708">
        <property type="entry name" value="Pex19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038322">
        <property type="entry name" value="Pex19_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774:SF2">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04614">
        <property type="entry name" value="Pex19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33065" checksum="D1F808634A5D9B06" modified="2022-01-19" version="1">MSEGKDLHSTNPQDEDPELDDLLDDVLDDFSAPTSSSAAKKPAAPTATTVEQAGDDEDLDAMLDDDFAQQLAAGMEELMGGAGDGQDEFKETFEKIWKSFENTSLDDPATSATPEGPVDPETKKTFQETIAQTMNKLRTSSDKVETDLSEEPDDAFMAEMMKQMESLADNGDFQNMLEGMMGQLMSKDLLYEPMKDLAAKYPDWLEKNKDKTPPAEYEKYEKQYEYVKQIVTRYEDPKFDEKDEKQANEVVDLMQKMQELGQPPAEMMDEMAPGMNLGPDGMPDMSKLNEQCSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFC1</accession>
    <name>A0A8H7PFC1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">3-dehydroquinate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_000210</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFC1"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08195">
        <property type="entry name" value="DHQS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000135">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050071">
        <property type="entry name" value="Dehydroquinate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43622">
        <property type="entry name" value="3-DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43622:SF1">
        <property type="entry name" value="3-DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24621">
        <property type="entry name" value="DHQS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="3-dehydroquinate synthase N-terminal" evidence="16">
        <location>
            <begin position="79"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="3-dehydroquinate synthase C-terminal" evidence="17">
        <location>
            <begin position="192"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF24621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2172860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="660" mass="72986" checksum="905574D0B79AD98F" modified="2022-01-19" version="1">MVQQQENIVKVSILGSESIILGYHLLPYLASDLVQNVKASTYVIITDRNIAALHLNPLLDAFQDAQRKFGQSVRVLFKVIPPGELSKSRETKCAIEDWLLEEVCTRDTCLIALGGGVIGDLVGFVAATFMRGIPFVQVPSTLLAMVDSSIGGKTAIDTPHGKNLIGAFWQPKRIYMNLSFLSTLPKREFINGMAEVIKTACIWNEQDFEKLEQGVEKIQDAVLNGVKDDFTGTTMETRTEGQCLLLDVILASARVKAHVVTVDERETGLRGLLNYGHSIGHAIEAILAPQVLHGECVAIGMIQEAELSHYLGYMDRASIDRIANCLSSYGLPISLDDERLLCRSGGTPCPVDTIMSNMRIDKKNAGSVKKIVLLSQIGDTVEKKASAVGDQEIETILHEQQPKKAVKQTPTKSVKVSVQRCFDNSVFKSFVSLSFPDYREVPTETLQAIAKDTSAVEFRVDLLTDPDNDIPSKEFVQQQINILRSKIGKMPIVYTVRTKSQAGTFPDDQENKMFELLKLGVANQCEFVDVDMTCSDARIQSFIENKGSSQIIASFHDPDSKYTWSSGMMPFYVKAAKYGDIIKLIGTATCMRDNVELEAFRDKVKDGKPLVAVNMGELGKLSRVLNSFFTPTTHSLLPYVAAPGQLTDQQIDQWRMQLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFS1</accession>
    <name>A0A8H7PFS1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFS1"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF95">
        <property type="entry name" value="F-BOX PROTEIN YLR352W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="104"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="543" mass="61433" checksum="7E1AC64F50AD4A8A" modified="2022-01-19" version="1">MTTISEQSPYFVHQRCLREDHPFFSVVVKLQQTKQRSSTHGHSIRAFTHITKRFCPVRYTHKRYLAYDSHIMKAFNLQFTPSALNSATPLSMQSTQRLLPLSLPELLTHIFQFLDKENALYPALLVNKEWHDCASRVLWKRVIFEDSKESIQRYEKFARVFGDWQKSPEQLSTTRSMPYALDSMARGVITGNGSEQQDINMMMPQQQGNGTEKGRGLLSFATFEGAIRCIAPQPRRTQSDRSLKRKIVGDFTDFQTRYAGGQGSSTDSSVFDLEVSSPKHSDRHATSNIVTYRKALRNLSLRKIKEKSINESLCAIAKHATNLTNLDIYICDHLEDETVIRFTTFHITPSTPISSLTQISLAGCHRITDASVIAAASHCPNLEHLDLRACGLVSDVSISAVALNCPRLRHLNVGRIRDRERITITSIRLIAQRTKAAVLGLAGCDISDECMLLLAQNRKSGMERISVNNCYRITNESIRAFVKLCPRLSVFEMKECHLVNDWASVAELVNRKVLLTLCEQQNKACLDWAKSKGKSMKVRAPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFY8</accession>
    <name>A0A8H7PFY8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFY8"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="79"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2173246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="319" mass="35684" checksum="C8C40743D52AAB17" modified="2022-01-19" version="1">MQSSPSQQSGQQQRLQQQQQPMPQQPLQQQQPMAGGPAGMTRTTSALSASKVGGATQAFPEGFFYIQSKTYPNLTMDVDANICLWDKKEVDNVNQLWAFEKGFISNKKSGLVMDIRGGEIAPRKHIIQYTRKGAFARNQEWTFVDGAICPASNVRLAMDIEANTASAGVNIVLNRRDVNRPSQQWVLLQHNPQELQQQNQLLLPLSDREREVLEKTQIKLSDLPDNHRMLYKQHASDVTDQQMAGAAAFEAIRQYISECRAKQRPYADEQSAQTISSLVTQEIVKLTSSHDVIGDRSAVERSAQAAADMYFGREYLTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PG66</accession>
    <name>A0A8H7PG66_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BAG family molecular chaperone regulator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_004468</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PG66"/>
    <dbReference type="OrthoDB" id="417450at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039773">
        <property type="entry name" value="BAG_chaperone_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12329:SF16">
        <property type="entry name" value="BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12329">
        <property type="entry name" value="BCL2-ASSOCIATED ATHANOGENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00264">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="28"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="BAG" evidence="3">
        <location>
            <begin position="125"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2173095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23497" checksum="856A9B262E604310" modified="2022-01-19" version="1">MSDTELELRWKGHAYDINFDEFPNGLEQATLADLKEKAKRVTGVPVNAMKLLASGAVMKDDSSPLSLYGLRPGSKVLLLGQRPNILTQSFQARLTEQTASGNPEEASLISRINHILKDMNDNMTKINQYEHEVGKFVQSRNQDPKAKKKLLEMGMFLSEKLMQALLALDGIQCQPGFHTARQKRKEGVNLAQDLHDRVDQIKAILKNASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGL7</accession>
    <name>A0A8H7PGL7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_004658</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGL7"/>
    <dbReference type="OrthoDB" id="10254721at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000658">
        <property type="entry name" value="PRK00029.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2173284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="582" mass="66476" checksum="516DF90364D87BEB" modified="2022-01-19" version="1">MLRQTISSMTKSLADLPLVPPRLTSSLPHDLMTPPDQTVTEMVMRQPRPVRNAAFSYVMPEKAPRPHILSVSNAALKELDLDPEAVKSQQYLDVFSGNHILPNTNPWSLCYAGHQFGYFAGQLGDGRAISLFETENNRGKRWELQLKGAGRTPYSRFADGYAVLRSSIREYLGSEHMAALGVPTSRALNLILTDREVYREDAPSDVPQPEQGAIVTRMAPSWLRFGSFEIFHSRKEKENVKKLADYVLKEVIKIDQLSSENKGNRYENLLREVARSTAEMVAGWQSLGFNHGVMNTDNMSLLGLTIDYGPYQFMDYYDHQYICNHSDHGGRYAFSQQPTVCMWNVFQLGKTLLELIGAGEEVDEVDITKIDNEEKLQQYRKAGEEIVNNVAGEELGEYFMKYFTDNMRAKLGLATTDSSDMENVIGPLLHWMGEYKIDYHKFIRSLSDYQITEDGEERDADNAIEKLNIISGLKKENKAKEDLKPWLSIYRHRILLSKLDNEGRKQKMDSVNPRFVLRNWIAQEVCAAFDEKHEDEASAMLESCLQACIDPFKSKYEDEQIEKWVQQDVPQWGRDLKCSCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGT3</accession>
    <name>A0A8H7PGT3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGT3"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="228" mass="26122" checksum="770351E49BB5ED00" modified="2022-01-19" version="1">MNMYSTYNILNLPLELLCNIFATLSPQDLYQLRQTSRACALLADHPTLWRSTVLSSTSQPWSQLQLRRILSTNAKHIRHLRVYNVRDDSLRYILTACPNLRSLYIHGWSTLSSHSIAGTSILPYLEKITLISSHHASLDAGSVVGLLKRAPGLQELHARCPTALRSQPFTSSLMASKLLIRLQSFEIYSDTHWYDQEKRNLTKACARLSRCKFLYYREDAIKSNEQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHB4</accession>
    <name>A0A8H7PHB4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_004640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHB4"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2173266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="57835" checksum="3FA4A909FB18D4D9" modified="2022-01-19" version="1">MNNVKPYVESAVERINKLSNEQKVAGVVGVASVIVLSSYFTTSSRKNLAPLVTEKTIAGVNIDQDLRGWLQVASQKYGNTFRTKLYGQTFTVVGKANAREVFLNDGFSFTKAIADKFDVAGMFGIQNVDDYDLGPIITRHLTPNLTVYNKRINEQANLKLDELVGPAIDEPKTIHHLFPFIQAIVARTSTSVFAGEELCKNDVLVNCFGTVTMDIGSNLKKNWFMDTFPSIDLFYQRNIFPRSPTIQNHRKNAKEILTPVIEERVRRLDDPNYEKPIDMLQTVIQLHDPKKEYGIPYTDYIINWMFILVFVSVHTTTENATHALYHLVKYPEFRKEIVEEQKRVLAEEGTEGQANKFTYDVLKKLTKLDSFIREVFRMRTTDLQMQHKNITKRDIVLSNGFSVPPNSNVYVNMWDIGRDQELQGEDPEVFNPWRFLESAKQAVRIGNDNVFFGLGKHACPGRFMAVNSMKTILSNILYRYDVVADGDITLANNFMDMPMGVVLFKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHC6</accession>
    <name>A0A8H7PHC6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_004655</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHC6"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="54"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="463"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="494"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2173281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="518" mass="56329" checksum="4470BA24C1D6EC03" modified="2022-01-19" version="1">MAESPVKEEARSVSPVEQKPSWGQRIKNSIWQKPDKHENAWRLLTNLTSTQRITFTAAFLGWTLDALDYFSVSLTATKIAADFNVPVSSVTGAITTTLMLRPIGALIFGAAADRWGRRWPLLIDILLYSIINLASGFAPNLQTFIGLRAVFGICMGGEWGLGASLALEALPAEARGIFSGILQEGYATGYLLAVLLNYGIVDAGGKSWRVLFWVGAAIGSLAVLIRFFVPESETFERTAEARKASGVTYWQEVKTVLRTSYLRLIYVVILMSFFNFMSHDPSFLSTQLGYTGTQVTVTAVIYNIGAIVGGTIVGYYSQYFGRKRSIVVCAIVGGAIIPLWAFAPNIASLQFGAFLMQFCVQGAWGVIPAHLTELSPPAFRGIMPGLAYQLGNLVSAASSQIEATIGEHYPVRLSNGEVKYDSTGKPVANYALTQAIFMGCVFAGVIITTIVGKEERGKDFNAHLVTNPTTGEPIGADDLDAVRTEEGSNSNGAGERRQSDHSYTDEKHDEQIEEKERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHD7</accession>
    <name>A0A8H7PHD7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_005298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHD7"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060962">
        <property type="term" value="P:regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22701">
        <property type="entry name" value="FHA_FKH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045178">
        <property type="entry name" value="Fhl1/FHA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21712">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN FHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21712:SF29">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN FHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2173878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="339" mass="38459" checksum="60EA137576083041" modified="2022-01-19" version="1">MTRPRPKLAGFSWTHYITYDNVILGRSQSNDDSDVKDARHVSFGTSKAISRKHAEIKHDTIKDRWELYVYGRNGVKLNGLFRKPPCKPVVLETGALIDIDGNQFVFVLPVSANSWNSSTTADKNLLTRSTYGDETIESLIVDAIESTTFDVTAKNIYEYIDTKRKNELLPPIALDRVTQILLDNPQFQLAPGCIDGTSPDAVWTIVSDNDPVDFHESQDPPSQQLLRREASFQRETFSKSVVSARDALGIEWFYVISLDVNSQPTKVNIQRDYERFSQLQFGEALRFHQSRKRSFDDYGIEPRALKRIRTTEYMIEREVSTASLTVSDILDLGELNGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHT6</accession>
    <name>A0A8H7PHT6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_004249</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHT6"/>
    <dbReference type="OrthoDB" id="415315at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000095">
        <property type="entry name" value="Mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="30"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="126"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="236"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2174228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="40819" checksum="B47F882AB6782043" modified="2022-01-19" version="1">MQELGASAKTTNKQRYFVHAAHSDAAGGFPPYLDVCVAGGIGGSLADFMMHSVDTVKTRLQGQAQHRPMKYHNMLQSYRLIWKEEGILRGLYAGVTPAMLGSIPGTTLYFGTYEFTKRTLTANAVPEFIAHLCAGSFGDLAASFIYVPSEVLKTRMQLQGRYNNPHFISGYNYRNTWHATKIIVKYDGIGALFHGFRATLVRDVPYSALQFAFYEQFKKLAKHTLIEPGEQLPVAADLLTGSLAGAIAGAITTPLDVIKTLLQTQIKKKRPNSSSELHVSASVPSSSIATSPAQSQAPAQPKHYSSIIEGLVWNYKHQGVGGLFRGIGPRVFWTSLQSAVMFVIYEQVLHLEERLRETGEWPPSQAIARLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHV3</accession>
    <name>A0A8H7PHV3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHV3"/>
    <dbReference type="OrthoDB" id="10458935at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034378784" evidence="1">
        <location>
            <begin position="21"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2174329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="309" mass="34264" checksum="13CDDA737E97305F" modified="2022-01-19" version="1">MKFTLFHAASLVLAISSVSALPRPRTNAHAKVHAKAPNQVKVVKMVDTSMAKSHSMSVSKKAQAINKDSVDNTPEDLNDMFGRVDYELKIIEDFFDELSMLADDIQSADMRNRQAVDDMNTGDKLALLNLLDIIKSLTSQITAVTDGMERLDSQSFLNNLLLPIDHAGSLLMTFESELEGQNYPDVERYISKFVMSLGNFKSTILSLKNTMPSKSDDIVLDKFDDLDIAGPTMTAMVKRQEPRRKIQSKGYKHSTSAIEVPKAKATHPILPQEVIDAFAEFDDSRPEIAEMANAIEEAVEEATPTPTMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHZ5</accession>
    <name>A0A8H7PHZ5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_005014</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHZ5"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF1">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="5"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="127"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2173596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="418" mass="46374" checksum="DE13B06BCD549C51" modified="2022-01-19" version="1">MTVQKVIIIGGGPAGLVLAHGLQKNGIPYEVYERDESPTSRSQGLALSLHWALPYIEKCMSPEHYKNITRASVNPFDADNVTFVVIDGASGETLIKHNNAAPYPTALNTVTSKSYRVSRRRLRDFLEDGVEIHWKKRFKEYELTDDGVIVRFKDGSETKGDILVGADGARSRVCDQLCGDKVQKNVLPFVFVAVTIPVNREQYQQLYKISSTHGVVTGPNFGPEGNRAIFFSMLDIDEANDQYKILIVMTWKNSSGEHGLPEDQASRVKLIKEIGALYCDPFKSIILGMNGDEVIWTTTILEKLPSPWNNHGKVTLIGDSAHSMSMARGEGKNACYKLSRPSCLLYNHCLSKFSACNYALRDAAELCDYLVEVNSGKLTAVQALGDYEDTMIKRSISAVLASRDAIYSRHTPKNSVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIR5</accession>
    <name>A0A8H7PIR5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_005790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIR5"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="111"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2174732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="692" mass="76616" checksum="81B1E74670F1DD42" modified="2022-01-19" version="1">MTSFLSSLFLPKHDNYLVEVDGDQHIYRNKLSGDELIRAPKHPQLADDQRTVGNIWSYVSEHHPDKQAFGERELIEVLDFLIFRFWYHQMHVSEKPATDGSGKNKKWYTPELSDNYKWITYGEAKKMTDSLAAYLLENGVKPGDSVLLFAKTSPAWMLTAMACFYAGIVVTTAYDSMPAEAVLHVLKESGATVVLTEVSLLGAFNKMMKDAPEGQVKIVLYGGKEMEDKKGLEQLQSSASRGWKVENVHDVMTDNHTSDKLTKSKPKSDDLAMIMYTSGSTGNPKGVELTNGNIVAAQSAAILLANDIISNYDHTYIAFLPLAHVLEFLLEFIFISSCVPIGYANIRTLMDDGVAGKDGQGRGRGDLKVLSPTIMTGVPAVWERIRKGIESKLAKQNPIVKTLFNLAIQAKWQLLKFFGKNNVITGIFDKTIFAPIRQVTGGCLKYGVTGGAPVSFETHQFINTTTCHLLEGYGLTENCGLAAVSLPWMGAATTGTVGYPSPSIEFRFVDVPDAGYKASEGVGEIWLRGPSLLRGYHLREDINKESLTDDGWFKTGDVGKINENGTISITDRIKNLVKLAHGEYIAIESLESKYRNCSDINSICIIAENGKDYILAAVEPADHDNVDKQKLLKSLQDTARSAGCSRVELIHDIFISNEDWTKNGFMTTSGKLKRNEIKKAFKDDIKKAYDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIU2</accession>
    <name>A0A8H7PIU2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_005811</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIU2"/>
    <dbReference type="OrthoDB" id="192733at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2174753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="468" mass="51826" checksum="B5192DCDDF39305B" modified="2022-01-19" version="1">MAAPNTEIVVVMDKDVEQQRLSFDEGSNTDNDQLVEYDPQPALQREIWGWYAYSWAVDGWTAASASVFMPLIISTMAYTGGRNVVDPAKPCNLAQPCMVKLGTSEVTPSSYTLYVTAIAILIQAIIYIQLGAVADHSGEFSYYLPKLARNTPSVRDEKDPVERAKKLTLQTSNISLSGFTAGYVGGMIQMGLSIGESQMSQSCVLYAMGSSFKGLIIGCAIGGIWWSLFTIIPHIFVTRRRGPLLPKGENYFTYPWKRLGKTMRRISHLSHLFQYLLMWLFLSDGLYTILKVAVLFAQTVVRASSLVILTGSLLTMAVGGPSTVLWKWIERRYSIRPKIMLIILSLLICFIPLYSLVGLSPNVAGGTLAYARSTFAEIVPIGRENEMYSMFLITQGGGGWIGPLITGVITDKTGNMRYCDLVILVFILVAVIWLYFINIEEAKKQAVAAAKFEAEEFGIKQIKDDQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJ98</accession>
    <name>A0A8H7PJ98_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_004339</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2A.Z forms a heterodimer with H2B. H2A.Z associates with the VPS72/SWC2 subunit of the SWR1 chromatin remodeling complex. Also interacts with RBP1/DNA-directed RNA polymerase II largest subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJ98"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000005">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="51"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="12">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2174316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="168" mass="18627" checksum="3B6826C9DCEEEAE1" modified="2022-01-19" version="1">MIVIVNIRSLATFNTTNAFLETDRLIHLTDRWHNYRTLFRPSADKAPELGKREKAPALSQSARAGLQFPVGRIHRYLKERSRNNARVGAKAAVYSAAILEYLTAEVLELAGNATKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVLPHIHKSLIGKTKGQKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJC9</accession>
    <name>A0A8H7PJC9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_006005</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01372">
        <property type="entry name" value="KISc_KIF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000011">
        <property type="entry name" value="Kinesin family member 21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25764">
        <property type="entry name" value="KIF21A_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="5"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="560"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="726"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1354"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1490"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="379"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="799"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1061"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="606"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="727"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1404"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1421"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1457"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1492"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="84"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2174943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1564" mass="177155" checksum="18CFF6AE2AA4B162" modified="2022-01-19" version="1">MSSTAVRVALRVRPLTEKEQLTNCSECIAYIPDEPQILIGTDKSFTFDHVFPGPQNQEQVYTECAQPLLKKFTDGFNVTILAYGQTGSGKTYSMGTSFDNGIQKEQQGIVPRFISDLFAQMEAQKLEMPEFQYEISVSFLELYNEDLIDLLNRPQTSRRRSTQGIPPAESVEVSIHEDVFGNIYWKGVREEPCSDPEELFSLLQKGSLCRTTGSTDMNAVSSRSHAIFSVILKQQQPPNMSSSNLQGDDEGSQSRTLLSKFHFVDLAGSERLKRTNAQGDRAKEGISINSGLLALGNVISALGDESRRAAHVPYRDSKLTRLLQDSLGGNSQTLMLACVSPADTNFMETLNTLKYANRARNIKNRVTINQEFAGSSIEVNQLRAQIARLKMENTALRSDGGSHDPISSHLREEETRGLRREVVRLRDRMQEMSNELLQATSERDTLLMERELGNFMPTDLDELIGSEGLIGTPSEVQNTPPAPVQQEGSIKTHPIIQHYLSTIQNLKSELTDTQDRLAFMESVKAPMMHAMSMTNGLSTSTTLSGITSQLLSGANRERYADLSSQMTTSSSSNRKKYRRKHRKVRMGQSNSSSTAKSRLPAYLQEAKNRNTDDEGIDVDSRDSDEMEDYQRTTGEIRRGVKSSIDKARNEIMKGMAVLQSTKNDENPNWEDEFDAYQASQRPKDQTSDQSSGDEIFSSLKVGEHTSSYGDWDKVLLDGTEKLEVPTWSDNGKVQTSPPNTARNSVSSEDVSIQLANVPRDENYNPNMVRMLHQIQSDIQVKEELVSHLEKSEMQYTFMRKKFEEQLASQQHAMNELQRERDIALRRATPNYVTRPDAAAQLRDKQQLLEVRHAYEAKMKRLFAETQELRRKYSQTARAMQSTRNQNDSMLRTLKVNVETLKVEKRRMIKRMKQDAMRVKEQLTAQERQIQLLRRKQAEVSIAKKRLEREHESQRRTLKRRDEEILMSNEQLKHLVNVLKKAVREGGVLDERLLNKVTGVIGGRFAIMSRGRSAFAAARKLNGKPTRRQNPVPVQLRLAKKKELLDIALYKYIEGKQAIVEMEQLLYKRECLAEEKAELTAEREQFLASERLRAMETDEEIDSSSMEYLDDRIELVSAEISYLSARIKAIQHDAANDAMVNDPMAMEAAQRQRMTKHVTFADEIIPSNGKDGWTDIDTLDDRYSLPYNAGPEMAYDTSMQLIKSLESDESRKLAQALVEDLMILRMEELGRQTTVQTLEKTVQDLRRTLLIMKRVAVSNHIKSEHQLQKVQSRHAVSTEDDANELRMKIEASINNGNTIFDRIYENGIRGTIMSPDGGDQMTNSGQGSPISGDDVYLSTPLMSPTRRSSNFQMEMRHGHHLKSPSPSPDRLLSMAQKHTNRRSIDGDVGLGMNDFMKYAGDRDSSTSSIRSNHIRRSSITSDSSLQSWNNVNGSARRRAHSLQQQPQPQPSPSRRRPSFRELSHGRRESMDMISPPSPYATMSYQRNFRRAPSVTSPNHSVASNNSERAMTPNGTVFDRLAQVHTHASQAKMSHRYSSGSVEELKLRWSDYERSGSAMSGSYFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJY7</accession>
    <name>A0A8H7PJY7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA repair and recombination protein RAD52</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_005951</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJY7"/>
    <dbReference type="OrthoDB" id="206565at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.80:FF:000001">
        <property type="entry name" value="DNA repair protein RAD52 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2174889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="33461" checksum="7912A0954AD444FC" modified="2022-01-19" version="1" fragment="single">MEMRASDTRQYGHGTFTPEETVYLQNTLQKQLGPEWISRRPGHGASTMSYLEGHSSINLANKIFGFNGWSSEIKSITTDHMEVTDGGRYNVCISVIMRITLKDGTFHEDIGMGSIENCKSKTQAIGKAKKEAATDATKRALRYFGTVMGNCIYDKYYTQQIAKVGLPPVSCEKKRFDSNELFRANAPALPLMAPAPVMTSYPNTATIPPVNNNSVHNVRNHQEDTVRQSTSNGSSSSLRQSLSAVSAPMNQLMAVPDNTVEVKRDQQEDSFISYDDDPSLYAQIDEEAFEYAGSEDDIENGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PK94</accession>
    <name>A0A8H7PK94_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PK94"/>
    <dbReference type="OrthoDB" id="2380640at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024368">
        <property type="entry name" value="Ecl1/2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12855">
        <property type="entry name" value="Ecl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="124" mass="13740" checksum="716891B264DE47B6" modified="2022-01-19" version="1">MSIMCDTNWCTYCDKQISPFSSSLYCSEGCLRSDALEHHPMLGYQYPELQDFPHSTSSTSPSLTATSSSTVSSPTLSPYMKTMSYSRLSPPPFSLGQSVSSSVDQRRPSELPTYKSSKKRVFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKL6</accession>
    <name>A0A8H7PKL6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_001250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKL6"/>
    <dbReference type="OrthoDB" id="10001928at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF2">
        <property type="entry name" value="NEGATIVE REGULATOR OF SPORULATION MDS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="424"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="626"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="642"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="672"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2175603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="705" mass="78615" checksum="75A4103031B75F86" modified="2022-01-19" version="1">MPGLQSIADLTTQLRTTTGEVPPPLVGASTTVVNNSLYVFAGRTVSSRRMTNDLYVLDLESFIWSRFIPPPDSEPAPKSRYFHSASVYQDKIVFFGGMGYSRTSTEGLCALDDVCWLDTITMEWHYIESLPTLFNARPRYAHLSTVSGNKLIIVGGQDLNNQYISEINVFDLELLQWVQVCPFERQCGAYRSVSVSPSSSCSVPLFGSRSWEEETSYEGDKNPNIQRRQSILNKNNTLFRLSYSSPPVTSVENPVYIYSNYNFTDVKRELQLFCSPNAAPNRVQDHSTGMSGTALPPGLRFPTGHILGHHMILAGTCLTPSTQMFQLWALNLTNLVWTRIDSGAILSSGSWNRGILHEASSRFLVLGNRDRSLLDDYNHRQVNFDHLATVDTEAFGIYIPPASTCAPIAQELGLSVLNDPVMADFEILSADGKMFPVNSLVLSERWPYFAEMMVKAAETPDVHDEELKEKIEHDSSKLATICPKSRTMFFPESHVTTLAFLQYIYSDHLLTSEQHQPHILCQLLLLSDMYDLVRLKELATHALHQMLTMTTASQIYETAALTGRTSLQIRALKVMISAKKMMQRGINPAEFTGRREFNGANRDDHPIVVDNSRMSMLDEAMIPPSSPLPHGMVRAHTVGPVPQQPSSPMLPPPSPGMRSKSPPPTPKASKSNTLSNLVSRNNQKKMAAKQYAANGSGTMYFPFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKR3</accession>
    <name>A0A8H7PKR3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2175006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKR3"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="87"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2175006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="444" mass="49628" checksum="17A5F0230EDFF247" modified="2022-01-19" version="1" fragment="single">MDRIRQIVRGMPNQISVPTVKAILQMNPPSAARALMNDLTKPLKHELRYIKKVHAGSWRGAWIGDKMRDMENYEQVKARVQEADLIIFYIHGGGFRIGTSTMYMKAFISWIEKLKDNGLNAIIMSVKYRKSLLLNWDLGQAAKYPEPTEDCVKAYQYLRRGLGVPGNKIIVAGDSAGGALLLETMMDANAPETYDHLGGKDAIGASEGRRNSLPAGMMLSSPLVTEQFNAPSWKENEKHDLVSTKFAKQVLREYFDPEVAPTPDTMKVLALARMEKGFEEFLPNNILVFLGKKECMRDDILELSDRVKKNSSITVQVVQENLFHDWFVIRDLVKKKSILEQNDKVFIRFIKSALEQAQGRILHSSSPLQDISVRRRQSIIRRNSTASSIITNSTVHTAHTALESSTAAETELLETLSQVEAQSNGGKSNATSPLVSPSILGLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLA6</accession>
    <name>A0A8H7PLA6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_005365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLA6"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="108"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="148"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="354"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="367"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2176132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="447" mass="49741" checksum="D9CBC160265F878C" modified="2022-01-19" version="1" fragment="single">LPVTTTTEVSSQAVVTVIIIITKTYSKAPRAGSDRKLVKEFEAFYLSQTLLDPHYEQSATDPILTMKFSQDGQYLATASKGGVVRIWQTSPDAYMLDDHFVTTPVREFTSHKGAVLDLSWSKNNFLLTSSMDKTARLWHVDRNDCLCIFQHYDIVTCVEFHPKDDRYFLSGSIDAKLRIWNIPAQCVHTWSKISDTQMITAAGFTQDGTRVCAGSAQGALHIFKSETLELEGEVCLGTDRKVTGIEPSPTHPSLVLVSSNDSITRIVDCNQKQSLCSLKGCTNTGMQIAATFSDDGKYVISGSEDRRVYIWKTADEIYALAGEDSLSDQETKVPSEVSEESACLTKKELKELQKQEKREAKARKKREKDQMKKLAKNEPEHFEAHKDTVISAILAPLETRRRLSMDGTMLVSADQAGCIRIWTCSPPNTDGDGNISSSSDNLRDTMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLM4</accession>
    <name>A0A8H7PLM4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLM4"/>
    <dbReference type="OrthoDB" id="2423722at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="233" mass="25136" checksum="11F17E60F8D494B8" modified="2022-01-19" version="1">MSFRRSSSTVQRDLSSLESGKASIIIRSHKGESRYDSQTASALSASKSSLTEKHTLHTDVNSINSSDIIDLQSETADFDAASQQALANVLAAAIQFSTIPVNQRSSLSSGRASVVLPTSHSEQPICRRDSGSSMSSNDSTSPKTPTNIRRLSSFFGLNGIKSSSQQRRPSTSTLDGNDECNIVKTNDTFGLQDLLDRGIQVKEISATRRKMVVPDNIVNPMPSISVARPSFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLP5</accession>
    <name>A0A8H7PLP5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SDE2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_005532</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLP5"/>
    <dbReference type="OrthoDB" id="27325at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.90:FF:000003">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1500:FF:000001">
        <property type="entry name" value="Nucleosome assembly protein 1-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053822">
        <property type="entry name" value="SDE2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22782">
        <property type="entry name" value="SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDE2-like" evidence="4">
        <location>
            <begin position="480"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="368"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="604"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="607"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="629"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="680"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="727"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="737"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2176298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="750" mass="84165" checksum="AE142615767D4461" modified="2022-01-19" version="1">MDQQQSAGVEIKNKKLEQFTAPTPQNTPSNPAPITSTYRPTVESISEDMETINTGAAAQGAAGAFSANPALLSMLQGRLGSLIGRSSGYIESLPTDVKRRLNGLKYLQTKHAEIETQFQEEILELEKKYLELYRPLYQKRTDIVVGKVEPTDEEVEIGKNADGEDEDAAAEEDKKENVDDEKTTGIPEFWLTALKNHPQFSEIITEKDEEVLKHLIDVRMSYIEKPGFKLEFDFEENEFFTNTTLTKTYFYQDQTGYGGDFVYDHAEGTEIKWKEGKDLTVTVETKKQRHKDTNKTRVVKRTVPAETFFTFFSPPAVPADGDVIDEDEAEGLDEKLEQDYDLGEEFKEKIIPHAVDYFTGKALEYGDYEGDDDFEDDFYDDEDEEDDDEDDDDEEDDDDDETAIVNSFTDSKPICLGFNPEGNATVNDLKVRLHSITNVDLTDQRITTIGGKTLDDDSLLFNANDTEGPIIYNLSVRMFGGKGGFGSMLRAQGGRMNAQKSTNFDACRDLQGRRVKAVNDAKKLAEYIEQAPERERQKAEKLKEKIEKALQEPPTKKYRFDDNQFMEDREQVVESVKLAVGDLLKNGGASSSRPKAAKAQVAVMSVFDDDEDDEDDDDEDEEEEEEQVVAESSSSPVAEPISNKSKGKGKAVELSDAIESPNENEEEEEQNTALAAFMEADLDDYDSDEDENFEAASEESEESSDDIDEDDLVDEDDISDDENPTPKAQSSSSATKGKGKATRKRKERED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLU4</accession>
    <name>A0A8H7PLU4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_005343</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLU4"/>
    <dbReference type="OrthoDB" id="2516at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000004">
        <property type="entry name" value="Diphthine synthase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000004">
        <property type="entry name" value="Putative diphthine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2176110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="283" mass="31841" checksum="CC4E4C3ECEF04551" modified="2022-01-19" version="1">MLYVIGLGLSDEKDITVRGLEAVQSCERVYLEAYTSILMVDSNKLVEYYGKQVIVADREMVESESDTILADAQNINVAFLVVGDPYGATTHTDLVIRARELDIPVQVIHNASIMNAIGACGLQLYNFGQTISIVFFTDTWRPDSFYDRIKENRDLGLHTLCLLDIKVKEQSIENLARGRKIYEPPRYMTVNQAVEQLLEVEDKRGEKAYTSETLAIGCARVGTAEQRLISGTLQQLLDADFGGPLHSLVLVGKRMHELEAEFVKEFAVDRANFEEIVKKDYSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLX1</accession>
    <name>A0A8H7PLX1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-5-taurinomethyluridine 2-sulfurtransferase</fullName>
            <ecNumber evidence="3">2.8.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_005348</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-taurinomethyluridine(34) in tRNA + S-sulfanyl-L-cysteinyl-[protein] + AH2 + ATP = 5-taurinomethyl-2-thiouridine(34) in tRNA + L-cysteinyl-[protein] + A + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47040"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11732"/>
            <dbReference type="Rhea" id="RHEA-COMP:11733"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:87171"/>
            <dbReference type="ChEBI" id="CHEBI:87172"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.14" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLX1"/>
    <dbReference type="OrthoDB" id="3685at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="MnmA_TRMU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.280:FF:000001">
        <property type="entry name" value="tRNA-specific 2-thiouridylase MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000115">
        <property type="entry name" value="tRNA-specific 2-thiouridylase MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="MnmA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046885">
        <property type="entry name" value="MnmA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046884">
        <property type="entry name" value="MnmA-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="MnmA-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001138">
        <property type="entry name" value="PRK00143.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933:SF5">
        <property type="entry name" value="MITOCHONDRIAL TRNA-SPECIFIC 2-THIOURIDYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933">
        <property type="entry name" value="TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03054">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20258">
        <property type="entry name" value="tRNA_Me_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20259">
        <property type="entry name" value="tRNA_Me_trans_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like central" evidence="13">
        <location>
            <begin position="204"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like C-terminal" evidence="12">
        <location>
            <begin position="278"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2176115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="370" mass="41039" checksum="11C4745B63A57CD5" modified="2022-01-19" version="1">MSGGVDSSVSAILLQQQGYNVQGVYMRNWDTADERGVCTSEEDYRDVQSVCKALDIPCRRIDFTKQYWNQVFQKTIDDYELGITPNPDVMCNREIKFGALLENCMANTRAGAGQEVWFATGHYARIQRADGAVKLLRGVDRTKDQSYYLSSVDERAYSRVMFPLGHLPKTAVKGLALEHGLESIVKKPESMGICFVGKRTHFADFLSQYINAQPGPAVDPNGKVIGQHRGLFAYTIGQGAHIHHGTDRWFVAGKVTKTNSLICVPGTNHPLLFADRVNARQWIWINGEPLGLSKPGDTLELDGQIRYRQSPLKCTVEKMSDGTFAVQFHTPIRGIAPGQNVVVWDGDWCLGGGVIDNVDNNKDASNEVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMY0</accession>
    <name>A0A8H7PMY0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Non-hemolytic phospholipase C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMY0"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF1">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034259820" description="Non-hemolytic phospholipase C" evidence="2">
        <location>
            <begin position="20"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2176876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="597" mass="64586" checksum="5B856D5DC707790C" modified="2022-01-19" version="1">MKAITICAAIAATLAFADAAPTKKTTTPSSSGLSKIKHMVYFMQENRSFDHYYGTMAGVRNFADPNVGVQSNGNNLFYQPDTNSPDKKNGSTYLLPFQFTGNRAGCTVGGSNSWTQNHNALNGGLNNNWPQGNSPMSMGYETRSEIPFHFALAESFTIADMYFQSVTGSTNPNRVVWMSGTNSYGGYTLEDNTESPALKWGTYPQNLTAAGVSWQLFQDKDNFDDNALAWFSYWQNLPSGAEKNKGLGVLGLQAFYDRAANGTLPQVSIIVGDTELSEHPDNTPMAGAWLQQQVVNAVMHSPAWNQTALIINYDESGGFFDHVVPPQAPSSEYVVDKWTGKKVPIGFGPRVPLVCVSPYCRGGNVFTEVADHTATLRLLEEWVGQNANGTYKAPASLISPWHRSTTSNLINLFDFNNPDFSIPTLPTVAKPATNSQGVWDPTEMCEGLSDPKSTPPYGKQTFPTVETGSKPVRGALTEGRTLVIRPTTSTSIQVAANGKLAIQKTSKQGSQGEAFSVHQSGDKYAIRSIGSGNCLSLQGNNVTLANCATADWTINYIAESASYQITHAASGKHLSAGSEHLQLSKKATSFKLYSVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNE2</accession>
    <name>A0A8H7PNE2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_007899</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNE2"/>
    <dbReference type="OrthoDB" id="434619at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08829">
        <property type="entry name" value="SPFH_paraslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000008">
        <property type="entry name" value="Stomatin-like protein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032435">
        <property type="entry name" value="STML2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF10">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16200">
        <property type="entry name" value="Band_7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="81"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="371"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2177242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="410" mass="44798" checksum="6A7EEDD620300773" modified="2022-01-19" version="1">MSNKALSLMRLRPRQPSSQIQRAVNLSLRNNSAAQLQALSVIPKRFVSYGNYGYGNDYDSYGNSGASTGWGTSRRSLPRNTVVKFVPQQEAWIIERMGKFHRLLEPGLNFLVPLIDRIKYVKSMKETAVEVPSQSAITQDNVTLELDGVLYFRVIDPFKASYGVEDAEFAVTQLAQTTMRAEIGQMTLDRTLAERAHLNANIVDAINGAAEDWGIRCLRYEIRDIHPPNKVVESMHQQVSAERTKRAQILESEGARQAAINVAEGHKQATILASEAEKAEQINKAGGEAEAILLKAKATALGIEKVAEAIGRDNGGDAVSMSVAEKYVEAFGKMAKEGTTLIVPSTASDAGSMVAQALSVYNTINKAKLAEQHGSSNRNAPTTAADRMRAEVTRDLVNAARKDPNNSEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNQ8</accession>
    <name>A0A8H7PNQ8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_007786</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNQ8"/>
    <dbReference type="OrthoDB" id="4951847at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="10">
        <location>
            <begin position="3"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2177130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="214" mass="24123" checksum="518E44A9177B4C56" modified="2022-01-19" version="1">MPRPPSDIWQHFTTFDDPSNKVKRARCNYCDHQQASSISRLQRHITRNCPSVPDIVRQEVTSRSAGRFKNIVPFVTYDTGPSSDLDDALQVLARASYNLPATSSTIPTARTMNMNAPPVGKIDNTTKNSLDWQLARALFSADISLKVIENPLIVQFLKRLNPNYQVPDRRQLQQVLLKREHWDLLADRRIDSTNANDAASADSQSESEGVSMET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPP5</accession>
    <name>A0A8H7PPP5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPP5"/>
    <dbReference type="OrthoDB" id="29851at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10232">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSsz1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000010">
        <property type="entry name" value="heat shock 70 kDa protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF32">
        <property type="entry name" value="HEAT SHOCK PROTEIN PDR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2177016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="547" mass="59611" checksum="FEEC6ECEE7CDA173" modified="2022-01-19" version="1">MSEQANVIGINFGTSYSSIAYMSKDGRTDCIANEDGDRQIASVLAFTGQEESVGSQAQAQIPRNPNSTVAHFRAQLGKSFTEAEELTGSAAPIVEKDSKVGYNVTLEEGNTQLFSAKEISTKYLRHLRESAEAFLGNPITGAVLSVPSYFTEEQREELKQAAADAGIKVIQMIHESAAAALSYGIGHNSSSKDPQDKTVVVCDMGAHSFDVTVLNVRTGIYNILATAHDTKLGGASFDENLLKHFVGEFKKKNKIDVSDNRKALAKLRAACEVTKKSLSSANSAPCFVESLADGLDFHATINRLRFEMLSKTVFNDALKVIEEVLTKSDLDASEVDEVIMVGGSSRIPKLASKFREIFNNENTKIRSELEPDEVVATGCAVQGSLIADFDDETITSSTHPVVTLTPHTTKHIGTLNHKGEFITIVPRYTSLPTRRIFEFGNAQQGQTQAYFALYEGDHDIVTEEIAAPPREPIEGDDDEEPYEDEPEIVKKVVIKPASKLLEAVLPLENGLEQGVAKIEVTLTVESDNKVNLVLREKKGNGVVKVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPT8</accession>
    <name>A0A8H7PPT8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPT8"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="538" mass="59942" checksum="D441ACF6133233B0" modified="2022-01-19" version="1">MPKRSRHQSPHDALISSKYEKALSLVQQLTASSGIQPSKEQKLQQVSGDVNTPRPGLFDVIGRAKWYVFSVWSGSYHNLPRNYDVNKSICRDAWKNMAVDPPTYPELALMPILVSIKAFQKSGANENARNILQALGSTKIDEPVEHPAETTDSQELSESDSENAEEQAYLADIQRDQMESSPAPTSSYQRSMSEAGITASRRQNQAKYARSLADSANAARPRFQSHDGMSNLHRSRRSSQSSVSTTDNVRSRYRARSVTSNQSGHRTNRSLVAGSLRDRRNINAPVRNRYSTHEDDFTGATRLWAQVANSSGQLPWEEFDSDDSIEDEKRATDASISEVDQSEVLMRGHLRNIDTSTPLPRHAGPLSSQSLASASSTAPRPSMFDSQRSSRAREQYMPTHSEKAPQSPSISVVDLGPATKRALQSLQSEVIALNGRLDGLKSELLEKDHLEPSSKGKKPMIPRSSARALGYSRKAGENDDDKNWEGWKWVVKAAARHAIFNLLTTFILLVILYKRKNPIATALSKQLYKLWIMLRKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRE8</accession>
    <name>A0A8H7PRE8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparaginase</fullName>
            <ecNumber evidence="1">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_001934</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRE8"/>
    <dbReference type="OrthoDB" id="542841at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009066">
        <property type="term" value="P:aspartate family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.40:FF:000001">
        <property type="entry name" value="L-asparaginase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006033">
        <property type="entry name" value="AsnA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00519">
        <property type="entry name" value="asnASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00057">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="5">
        <location>
            <begin position="54"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="6">
        <location>
            <begin position="344"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="551"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2179084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="736" mass="81606" checksum="144B4B298FBEF457" modified="2022-01-19" version="1">MKEPSKSLAQVMNQVSPTPASLLSNDAAHIFDNAAVEFQLSADREEMVAPDVSRVLVIYTGGTIGMVNSTEHGYMPLPNYLEKTLASVARFHDPHDPQGLQHRSRNNSEDNLSDILKASVLSKNSNDGVSESTGFTSKTPRQRMNAVNMISYNGPNVGDKVSLQLPSLITPVSLYGKRIRYSILEYEPLLDSCNMTMEDWIRITKDIECNYQNFDAFIILHGTDTMAYTASALSFMLEDLGKTVIVTGSQVPLTEVRNDAVENLLGALTIAGHFVIPEVSLYFNQKLYRGNRTSKISAVDFDAFDSPNLAPLVQVGINIDVAWQQVLRPVHIAKFKAHTELNSNVASLRLFPGITEHTVRMFLTSPIQGVVLETYGAGNAPARPDLLAALKEACDRGVVIVNCTQCKKGLVTDAYATGKQLTLMGVIAGADMTPECALTKLSYLLGKKELTVSQVRKLMTMNLRGELTVRAPRTRFTAHSRTHALIQTIVQASSSGDGNITSQTLQERVLIEKAMYPILLCSAAATDDMDGLLMLHENLGDMINFNCVDYDGRTPMHLACSEGHFKVVEFLLMHGASVHTRDRFGHTPLFDAVCEKREDVVRMMRLAGAHFAFDDFEDLGYKWLRAVRDNDSRFVRMAINAGWNLNWSEGVDGQRAIHIAVKEGRVGMLKTLLGESSLHANALDRWGRTALDHIDQLDQYHKSGSRYSKLTPEITSEMRTLIEQHIKRDISRQSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSS0</accession>
    <name>A0A8H7PSS0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_003650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSS0"/>
    <dbReference type="OrthoDB" id="21539at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01736">
        <property type="entry name" value="LSm14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025761">
        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025768">
        <property type="entry name" value="TFG_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51536">
        <property type="entry name" value="TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="7">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="DFDF" evidence="4">
        <location>
            <begin position="248"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="5">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="TFG box profile" evidence="6">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="196"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="350"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="1">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TFG box" evidence="2">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2179864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="403" mass="44354" checksum="2FE24012A9F7ADC8" modified="2022-01-19" version="1">MSGGQGYIGSKISLISRSDIRYVGVLHSINSEDSTVALENVHSFGTEGRKGNPSEEIAPSDNVFEFIVFRGSDIKDLQVFEPPAPKSAVPAPQQYPNDPAIMNSTMDNYTPKQQPQQQQPPVATNYNQAPYYGQAPSGGMPNQHGVSAPSAAPQEPVAAPIEPAASVGAQQSNMASKSREVTSIDVEKLAKSVSGMNVGTDKQPGQASKLPGTGEHLIKNNNRGNRNSKINVRYNAHGNQPNSNNTNNNINRVVVPKSDFDFEGSNAKFDKDHILKEVIHPHDDQHVEAENVEEEEEVVIPPPDDFYDRSKSFFDNISCEAKERQDGPNRYGDNRRKYHEERKLNVETFGQASVEHGRHRGYRGRGGHRGRGLHGGFRGGNRRGGQNRQQQQSQQQNQQSTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PT82</accession>
    <name>A0A8H7PT82_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PT82"/>
    <dbReference type="OrthoDB" id="69928at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="32724" checksum="B54801CDF591127A" modified="2022-01-19" version="1">MTTSSKKRPQQRPSRTRQGPLHVFKVLLDVTAFLDGLNCVRRWAGQGSDSATHLRGFICEVIVPLDTIDSLDEHKKGTSHANTQARESIRYLDQKLERSSGGSVPTAVSARESFLRTQRVTERLASWDDAQFYWIGEPDQLLSSDRNIQTDENEDEEVLLSAGESDSDDNDDTFLSSRLRRRADSDDSDEGSDESDLDSDASEEEEEEVITTYADIPKHYRPIISCLLYYHSHQTLTDTLSEPKLVLATNDQDLAWWVSHFGDPQTGKRLSTKRVDEWDRVVRTKAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTW0</accession>
    <name>A0A8H7PTW0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_001996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTW0"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10919">
        <property type="entry name" value="CE4_CDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052740">
        <property type="entry name" value="CE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985:SF3">
        <property type="entry name" value="CHITIN DEACETYLASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034302622" description="NodB homology domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="65"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2179146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="490" mass="52085" checksum="C1E0CB84C9C97EFC" modified="2022-01-19" version="1">MKNFAVSLAVAATLLSSFVVAQDGTPTIVQGGANPYTCDPTKCIAPKCLCASQSPPGGIKPADAPQFVTITFDDSVQPELIQTAADLLNVQNPNGCKAKGSWYVSMMYTDFALVQQWFAEGNEVADHTFTHVGTPSAQEIQAAADMLYSYAGVPHGMLKGFRAPFLNYTADTLKEIQAQGFLYDTSATAVVDDNYWPYTLDNGMANDCWTGICNPGTVNLPGVWEVPMYAVLDNASVPQLMDVYLSGTPEDVTNWSQTNFDRHYNGNRQPFGIYVHPTHLTNYPGLPDATAQKAGVVNFIQSLAGKPDVWFVTNDQLLQWMQNPVPASQLANQTYMQCQKPVTPKEICNGLETLNITSGVVSGPLLNACNFNTSNFATCYNCPGSAPTLETPVPASAVANGTSGYRTPLPDNCSPFWWDPVAGQCLCTTSSCAYQDTALPKQQNSTNGTSSGSSNGSSASSSGKASGASPGPVVASTLSIAAAIFISLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PU65</accession>
    <name>A0A8H7PU65_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_003710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PU65"/>
    <dbReference type="OrthoDB" id="2261218at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2179923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="416" mass="47136" checksum="3DC10B5E6C1070B7" modified="2022-01-19" version="1" fragment="single">SSPALSVRSIFKKSTMKLAVASAQRLRANKILPNLPAKSNKPVSLITDLQKSISSNDSISSPRMASSLTRTIVHYNGPARSLEEFPKETMEWLKKSTVAEDSDLGDNNNRHVTFKKATSQGHDVRSQNVAKQALKRILMRLSYCNDVSAPFTAKLKVYCQSKRTNLFGGNRTPTEICLGQDTLKFDSIWPMDKRIHRIDLQGSPENSSTDNFQILVSIGLHVNSTMKEVIQETRYHADYVTMYVRGGLTPRWQRYWAVLKGPNLQLFDFEYQEERPPLAIIPLRKFLSAFHPSVDDDDRQVDVGSMGLALQFSEQCVSADISNQEQIRELPVFERRMYMLADNLVGLSKWESVFEHISKIMKECRNSNSPAAPVPNAMESLSQNNSHSDFSGIKQLYENPSAAMDPEMAVFYKFLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PU92</accession>
    <name>A0A8H7PU92_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003636</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PU92"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22887">
        <property type="entry name" value="Atg16_CCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045160">
        <property type="entry name" value="ATG16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013923">
        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878">
        <property type="entry name" value="AUTOPHAGY PROTEIN 16-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878:SF8">
        <property type="entry name" value="AUTOPHAGY-RELATED 16, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08614">
        <property type="entry name" value="ATG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Autophagy-related protein 16" evidence="6">
        <location>
            <begin position="5"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="234"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="276"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="361"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="449"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2179850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="486" mass="54656" checksum="5F16FA23B831E241" modified="2022-01-19" version="1">MQQETLRLKEEIQRLKNEQTEMYKTQGQNAQRLVDMNDKLRAHEAAEKEANQKIESVSEELKLTTAKVEQQAHLLKQKDVAIQVLQDELSTLQLEFSTTEEKNKQLFKENSELVQRWLKKMNEEAEKMNEATMFYESLAEQAKNSDSSKASNRWMFRSKSSENDNEKMKRIQDIPLRISMVTLPKQPAQVQNIPDGEIHCIKSSPTGNSFAVGGSDRKVRIYSVRQGGTLTQTLSGSLQTLTSVRFNEGEDLLLGSSMDNSTRIWDLTTGRIRHTLTGHIGKVCSAEFTSDSNRVVSGSQDRTLKLWDLHKGYCTRTIFTFSSCNDVCLIDHEGSSIASGHLDNNVRLWDTRTGNGIKELTGLHSGQVTSISVSPDGSKLLTNSRDNTLHIVDLRMYKVIRTFKDDSYRNGLNWSRACFSPDGHYAAAGSATGTIHFWNTMTGKHESAVQGHKQAICAVDWSPIGAHLFSADRSKSICIWDTSTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUC3</accession>
    <name>A0A8H7PUC3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Serine/threonine-protein phosphatase T</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_003800</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Protein phosphatase that specifically binds to and dephosphorylates the molecular chaperone Hsp90. Dephosphorylation positively regulates the Hsp90 chaperone machinery.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:20630"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUC3"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07417">
        <property type="entry name" value="MPP_PP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000039">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041753">
        <property type="entry name" value="PP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 16" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="17">
        <location>
            <begin position="192"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="15">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2180013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="488" mass="55131" checksum="4B28E9E34009EDD5" modified="2022-01-19" version="1">MSNETVPQEATAKADALKAEANSLFAAKHYNEAIEKYTAAIEANPKVAVYYSNRSACYIKTEAYGYAIADANKAIEVDPSYTKGYYRRAIANMALTKFKDSLRDFKIVVKRAPADADAKSKMVECEKIVRRIEFEKAIEHNEVVRSVAETLDVEAMTVEDSYDGPRMDESTKNVDKKFLDQMILRLKDQKKIHKKYVFRIILAVRNIMLESPSLIDIDIPEGSKLTVCGDTHGQYYDLMHIFELNGYPSDKHIYLFNGDFVDRGSFSLEVVLTLFAFKWLYPKSLYLARGNHETDNMNKIYGFEGEVKAKFSETMFKLFSETFNALPLAHVIKKKILVVHGGLFSKDDVTLDDIRNIDRLSLRQPGTEGLMCELLWSDPQPEMGRGPSKRGVGIQFGPDVTKNFLDHNGLDMLIRSHEVKENGYVIEHDGKCVTVFSAPNYCDSVGNKGALINITSDMKLDYQTFDSVPHPDVRPMQYASQFGGMLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUC4</accession>
    <name>A0A8H7PUC4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cns1/TTC4 wheel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003842</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUC4"/>
    <dbReference type="OrthoDB" id="420195at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21380">
        <property type="entry name" value="CTWD_Cns1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044059">
        <property type="entry name" value="Csn1/TTC4_wheel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18972">
        <property type="entry name" value="Wheel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Cns1/TTC4 wheel" evidence="6">
        <location>
            <begin position="232"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="167"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2180055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="349" mass="39870" checksum="1DF382334A81C67A" modified="2022-01-19" version="1">MSASAGPDTSNRPSWALDADNLDASMSEVPLFMKELPDEENDTLAALQSLAFDGTPEEIAENFKNQGNDCYKKGRIGYQDAIKFYTQALDVDCQDQKLNEACYANRAAVNLELQNYGKVLRDCAKCLGLNEKNVKALFRSAKALYALDRLAEAVDCCEHALAIDPENKAVILENVRCQKKLDQLNEKKRKEEERKRKEEEKKAKIDQLVKERNITFEVTDESVAKTAQIQLDEETNTLSWPVFFLYPEYKESDYIQAFNETNTFQDHLEVMFEQAAPWDVRKEYTLDNIEIYFENTTGLKPSLLKIGKKLPLGKILSLDKYTIKNGVASFIILSKSCAFKEEFLARYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWL8</accession>
    <name>A0A8H7PWL8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_006905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWL8"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022408">
        <property type="entry name" value="Acyl-CoA-binding_prot_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00880">
        <property type="entry name" value="ACB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="13"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2181979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="109" mass="12537" checksum="5138833DACF19FF4" modified="2022-01-19" version="1">MSSADEQSFHQYVNQRYKRALGLVRNIPKKSLFQPSNADKLKLYGLYKQASFGDIHISQPDRWDLLARAKWEAWHQFKGLDSTSAKQQYVDTLIGCVILVSSFLGLKDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PX51</accession>
    <name>A0A8H7PX51_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">U1 small nuclear ribonucleoprotein 70 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_007176</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PX51"/>
    <dbReference type="OrthoDB" id="4207594at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12236">
        <property type="entry name" value="RRM_snRNP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001585">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034143">
        <property type="entry name" value="snRNP70_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022023">
        <property type="entry name" value="U1snRNP70_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF5">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12220">
        <property type="entry name" value="U1snRNP70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="100"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="182"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="260"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2182249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="289" mass="33108" checksum="0FF1F3D96D949D8E" modified="2022-01-19" version="1">MTDKLPPNLLKLFAPRPPLPYIPPLDRDPSKRKGAQISGIAQYFDQLKNHDPDYVPWKSIAERKKERMEAKKKAATEAVEQGVATWNPENDEKVIGDPFCVLFVSRLSYNVTEEDLKREFDLYGPIKNIRLIRDQEGKSRGYAFIEFEREKDMRAAYKDADGLKLDGRRILVDVERGRTVKGWKPRRLGGGLGSTRSGSADQRARSSGRNDSTSGGDRYRDRGGGAHGYNRYNGGSSRRDHGFSERRRGKSRSRSRSPRGYRDYDREHAGGRGRDRSRDRYESGPRRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PX74</accession>
    <name>A0A8H7PX74_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PX74"/>
    <dbReference type="OrthoDB" id="1060854at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF94">
        <property type="entry name" value="PHO85 CYCLIN-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2181923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="317" mass="35694" checksum="7FF8CD52FB0306B6" modified="2022-01-19" version="1">MGDNVRFDLGTNPTDVTIEALALLLNKIITANDHLIANETAKQEHTSTHRRNSQVGCTCFHARTIPSIDIKSYLLRINRYCPAKNEVFLSLLVYFDRMSQSSLHMRIDSFNIHRLVISGVTVASKLFSDTFFTNTRYAKVGGLPIAELNNLELEFLHLNNFDLYISIEELQEYGDQLMKHWYQHESGLNDTEPQAAAIPTPVKRKLSQPNQKDEDRSEKDSDTILKNDTRRMRQLSIDNGIGTGRRRSSSAGHTMTSTQPSAGSLERSTSTNMKDPKSTDPKLKEELKSSTNTEDVLFHAANANRTGFRGSVPQSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXF3</accession>
    <name>A0A8H7PXF3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXF3"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2182399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="68" mass="7303" checksum="F77FE76900F496C2" modified="2022-01-19" version="1">MQTYAKVSASNYIKSQPYLGHLDGTPERTENTSTQNKEGSVSEELVSGSTKEQQGVGRSLLGELSLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXP8</accession>
    <name>A0A8H7PXP8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXP8"/>
    <dbReference type="OrthoDB" id="340681at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2181051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="276" mass="30858" checksum="B87AA9CADCFD0967" modified="2022-01-19" version="1">MAAEPEASTSNSVNVTEEEDEIVQEIPVYLSTKLAQNLYLFQYPLRQLPFKPETGPCAARIKPKSNMLEVDIPLDTRAPTYDKARGDDLAAAVSGEKFKTVFDQDDNDYSGRPQTRALLDKQTLGSTLIPSKTKYLVGVLRDKELHVTPLTNTVQLRPTLSYIDKSDEKEKASMKRAQQEEVKEEPKAPVSKPQTVQMSVINAENENAPRKNMYSLSVRNADDESWVKLEYFDETTIAADAMYGDLFSSSKEPLIPTSTNESYADSISPMLFDISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXQ6</accession>
    <name>A0A8H7PXQ6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED17</name>
        <name evidence="10" type="ORF">INT43_006977</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXQ6"/>
    <dbReference type="OrthoDB" id="10251234at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114:SF7">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10156">
        <property type="entry name" value="Med17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2182051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="735" mass="82183" checksum="9BE937BD4A2A6941" modified="2022-01-19" version="1">MHDSNIDVLDRESSFQNKLMEKVNRIWFERGEWKSISGEALQENVARKRSREAGESPEPLIDNESRKALAESQAVLAEKAGQLPFPDAQRLRESVVGKLNHAKSEIDVALDVINIMLLSQSKATVTKDLVLPPNALQATYVARPKSAIKHEVDATKLALGSKRKQLKDASAFLLNSASSLERLVKSEQDFWDEALEMRRKCWLIQPGNASQPQPGGSMTPGERSFYVQYGFGDVGSKFKEPTFAEMTRAYDKSTGTDQQEAVQMLIPHTTRRHVIARLVENHIAGLDLNFDYSEKQLASKATASTDVDEDYLIFPQYEVQNLSALQQQLQLAQCTVFESELFLEILSEARSSNVEAKFTEDGVLVNIDVHNDLVLELKKDSDIVKNGINATESPQASLANNRKFAPIIINISMHLLLLRRYRYNILESKRKLFPNSALPPPPGAPVTGAHVQPTPTNRFARPTGAGNTTELTSHTRARSIPLFSFLSSQCKLLALVNRVRHGISDCIAPLCGEGGLDISVHYEMVGCKPSQSSTKFDNSPQSLAINVTVTVIKGQSLRYTLRPPNSIVAQLPQTSLTLTSVQTFTELFKRQLNLLCLQLICDEANHLLQHAGFNSSHRKTIPEKQLWTVDEVEEKVNGLLWCKSSANNKNSEIWRRIVIEPQDGSMMKKDETLSTCKHFVFTALGKKDMQLERLEQTLTLGNPAGSTSIESVLEFRQRARLTLTEWITKVRNQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYG8</accession>
    <name>A0A8H7PYG8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_007157</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYG8"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="13">
        <location>
            <begin position="8"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="14">
        <location>
            <begin position="120"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="15">
        <location>
            <begin position="242"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2182230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="385" mass="42268" checksum="6FB144C7CFD1E266" modified="2022-01-19" version="1">MSNNGETFLFTSESVGEGHPDKICDQVSDAILDACLAQDPLSKVACETASKTGMIMVFGEITTKAQLDYQKIIRNTIKQIGYDDSSKGFDYKTCNVLVAIEQQSPDIAQGLVQTSFNVEDIGAGDQGIMFGYATDETPELMPLTVILAHKLNRKMADLRRDGTLEWLRPDSKTQVTIEYKNENGAFIPLRVDTVVVSVQHSEEIETEDLRKAIKQHVIDSVIPAELLKDTTYHIQPSGRFIIGGPQGDAGLTGRKIIVDTYGGHSSHGGGAFSGKDFSKVDRSGAYIARHIACSLVAAKLARRCTVQLSYAIGVASPLSIFVETYGTSDKSQAELVEIVRNNWDLRPGAVVKELDLFKPIYQKTAAYGHFGRPEFTWEQPKSLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q100</accession>
    <name>A0A8H7Q100_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NudC domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_000318</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q100"/>
    <dbReference type="OrthoDB" id="428655at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037895">
        <property type="entry name" value="NUDCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664">
        <property type="entry name" value="CHRONIC MYELOGENOUS LEUKEMIA TUMOR ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664:SF1">
        <property type="entry name" value="NUDC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="6">
        <location>
            <begin position="303"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2184409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="612" mass="68506" checksum="B0675FA8ACB81412" modified="2022-01-19" version="1">MSTTTKLRFKSDRSLINSKFDGYKLQVFPEDTNLHRFQLPNVLSIPKLAMNSRLSYRELQARVKYNHLSISHQKGLAFYVDNEFSVVGVELSQTEDRIRFHKIAQLQAPLTDVPSYAEPDSTTPLLPQYPSLHSLSSDMLLASNGAGLIYTIKLNRDDATGDIMGKILSTSQFAGDGTEGLSPVPCVISDAKMVDEEINIITWSVASQENDVPAHLTLDAPTSKTLFNIAYSKLLVSTNDENAPADLSIQHILRGRDIPFYCEFDAEATGYVMGSAHPYELVFSSEDTEMKETPAETAGEKDNSVSPYRWVQSSDDLTIVIQLPPNTPKSAISCNFNVQHMSLMVQNDEVTICSYPFRKLWDTIDPDSSVWTLDVASGLLTIELMKKNENVRWLHVFEQDDQILEDLTPEQLKEIQERLEKFTGEGKAIGTPGWKQPLQHPIVTDMDEDIDHEGQAISLSWIDGDTGKIKAEVLAGGQEWISTSFKQPSSDKFSSVCLKLDVDGLVYAVERADPISVKHTATFNALAFVQASKRDQRFIYHDPENAFSVILEGTRNAYIYYRHDDGKRNTDVQTLVDLTEGHDVDVIGTQLIDQKVILVLLETSVVVIDLQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q132</accession>
    <name>A0A8H7Q132_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q132"/>
    <dbReference type="OrthoDB" id="2488381at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="301" mass="32536" checksum="966C43831094736B" modified="2022-01-19" version="1">MKSATYRYAQIKRLGVAARPFGYATRPAHPCPARPHKSRATPMAVDNPPLHVLMDVDPWWWVPDADPTLDEEASAGSTAMDWEPEQKGCPPLAPVLRVKAALPPTSGRLNRPKLKPLRARREAVPLVAPSSTTFQASAVRAAGSSGIGMKRPKDASTSHLLSSSQKRVAAEMSPSNAPVKVDSLECMVRSAQSPATQKAHSPFGSPRLRPRGLEPPTQEGLTQVDNDLLCLLGEIGSAPSAPPPQPQLVRVSVPVERSAAGQRIPEDVRPTRRERPQLKREGILSVILEEAEEEGLFLEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2Y5</accession>
    <name>A0A8H7Q2Y5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Complex III subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_000479</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the UQCR10/QCR9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2Y5"/>
    <dbReference type="OrthoDB" id="44067at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.260:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.260">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008027">
        <property type="entry name" value="QCR9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036656">
        <property type="entry name" value="QCR9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX, SUBUNIT X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05365">
        <property type="entry name" value="UCR_UQCRX_QCR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81514">
        <property type="entry name" value="Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2184570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="74" mass="8573" checksum="F12677D32D870E00" modified="2022-01-19" version="1">MLGRTFYNTLVKKNSVFIATIFGTAFAFEVAFDTTSTRVWDNFNKGGRLLPPIVHYNSVIGHKQWKDIKDKYEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q315</accession>
    <name>A0A8H7Q315_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">High-affinity nicotinic acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_000940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q315"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2185027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="47814" checksum="41C7E8F4EEEE6679" modified="2022-01-19" version="1">MASNNKLANVSDAGLNDYHANVSHVDERTSQRNNAMEKALVRKLDTKLLPYLCLMYLFAALDRSSLGNAVLDNFEEDLELKPGQFNTAIMIFYAGFLLFQVPSNILLKRYTAKRCKAEIATRIALFYSTSVLSHSFAGILAYYILRLRGASGLAGWQWLFIIEGLPTIAIAIMAFWYLPESPQTCPWLSEEERVLAVTRLTSGDAFDIEDMAPHEINKRNRQEIYEAIIDWKVWLWMLMFFCGSVPNTSVSNFLPIIIKGLGFDDKLAANLMSAPPYMFAAVVMIYMAHSSDKKYERAYHAIVGASLCFTGYLLLLLLTDRSTPSMKRSVATAMAVSANNSAGLLGSHIYKPDDSPRYLRGHSVNLGFISLFMILTLVQRYLLKRQNRIKAVLRESGEHQTLLEQPINRKLIGDRQLNYEYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3R4</accession>
    <name>A0A8H7Q3R4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_002377</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3R4"/>
    <dbReference type="OrthoDB" id="3063237at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="27"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2185939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="142" mass="16107" checksum="2C5CA7410BC49182" modified="2022-01-19" version="1">MSTDRKQLFGNYKGKGVNRDRDEENAYMLEQQNDYRMQELDAKVSALKNVTIDIHRDVTEQHDVLDESNNVFAGFGAAFQNSFGRLNRMVSTRHKRQLCLYVGVMVLAFFILYYGVGVFWSGSDSSPSNNDAGSIHNDADIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4C7</accession>
    <name>A0A8H7Q4C7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_002330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4C7"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="37"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="333"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2185892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="417" mass="47361" checksum="0ACB67B3AE13BCBC" modified="2022-01-19" version="1">MLQIKALPERRNFIFCVLVSSNLPFIMAPKSRKKNSTPLNIMVTGFSGVGKTAFVRTLCETLTNLETDPIPELSGPLSKTEKPYTVSLEFDYEGDRIALTVIDTPGFQVNTPIEKGLQEITEYIENQFDLAIAEESKVKRNPKAVDTRIHVCLHFLDVSRRELGANDLEILRRLSDRVNVIPVIGKGDTLTTAQRTALQPTIMRSIFDKYKIPIFGYPDLEEEEDYEVLDTVQEEDEEEEEESKEPNGDVEEEKPATTAAVEQPSSLYDEICNDTDLDTLDEETRGLVEYLQKSPYVLISYEENPETGRPIVIASKAQNNHVDEEEIAMSPQPSHVDTNSLIGRQYPWATLDCLNPQFSDFSVLKTLLLSSHRKLLVTETIERFYEGYRTEKLLLKKANKTMSVVMGKKILEELHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4J2</accession>
    <name>A0A8H7Q4J2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chorismate mutase</fullName>
            <ecNumber evidence="3">5.4.99.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_002183</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13898"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4J2"/>
    <dbReference type="OrthoDB" id="191918at2759"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.590.10">
        <property type="entry name" value="Chorismate mutase, AroQ class superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008238">
        <property type="entry name" value="Chorismate_mutase_AroQ_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037039">
        <property type="entry name" value="CM_AroQ_sf_eucaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01802">
        <property type="entry name" value="CM_pl-yst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145:SF12">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="Chorismate mutase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51169">
        <property type="entry name" value="CHORISMATE_MUT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate mutase" evidence="13">
        <location>
            <begin position="175"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2185748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="299" mass="34582" checksum="DF47712C21D1D0D8" modified="2022-01-19" version="1">MQNYDIDYKKPNATCNELPNPETPRNLGCFHMRKHGSAMPYHLDVLLACITMISTKYLILISILTALIERAQFSVNEIIYHKNALPFNGATGDRTFLEYFLWETEKIHAKVRRYTSPDEYAFTSPLPEPILPPLDYPEFLFPNDVNINDKIMDVYVNHLVGAICPEGDDKNYGSAATKDIDCLQALSRRIHYGKFIAESKFRSNPEEYTRLAMLNDTEAIDKLLTNKAVEMKLLKRLRRKALTYGQTLDQEEANISTLLKVPVDAVVELYERWVIPLTKLVEVEYLLQRGRAWHEEHQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4R9</accession>
    <name>A0A8H7Q4R9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal protein/NADH dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_002238</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4R9"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040049">
        <property type="entry name" value="Ribosomal_mS25/mL61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="5">
        <location>
            <begin position="41"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2185801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="115" mass="12172" checksum="CE6E87EBEF003074" modified="2022-01-19" version="1">MSTQTVLSRLQSGLGATRLAPKVTKISVSMALKGKSEGAGARHFVRENLPTIQYNNPSLEFEIIKSADAAMKPLLTVSFGDSIAADQSPKTIELARQQSSAICKQLLDIAAPSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4V2</accession>
    <name>A0A8H7Q4V2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_002585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4V2"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="46"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="4">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2186147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="154" mass="16951" checksum="1EA019B05F49D449" modified="2022-01-19" version="1">MSLRTFTSRFVRAYTPARVAPFQFTRALATKRYTKEHEWISVEDNVGTIGITDYAQKSLGDVVFVEIPSPGQAIQKGEQLGAVESVKAASDIFSPVSGDIIEANEALDSEPGLINSSPEENGWLAKVQMNESSELEGLLNEEQYKTHCESAEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4X6</accession>
    <name>A0A8H7Q4X6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_002455</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4X6"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="80"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2186017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="488" mass="52872" checksum="8AB54EB02F38264B" modified="2022-01-19" version="1">MHEEKHPESTDASSTINNNDPVGENDPQLDNFYEMHQTDTKNTATSLHSSTQHASADRDPSQLEKVDTRQSAKSFKEGGYGWFVCFSAFLCNVANGAVSALRTKKIVNCTDLLYPTGVMQNYYASSVFDGKVSAVQLTFVGTIAFIFINGMGPPMQILKSMIGARVLIGSGCLLMCLGLILAGFSTQVWHLYLTQGVMFGLGGSAMYITMMGIVPQWFDKRRGLALGLSASGSGIGGLIMPFIMNALLQKYGQGWTYRIIGFICLVLGTFATCLVREKYPSPGRKKISDIVQWSVLKDSNLVLWCVAATVTLFGYLVPFFYLPAYATSIGLSNAQGSSLIAMISGCNFVGRITTGYIGDRIGRLNMLIIAMVISALCNLVIWPLSPSLSGLSAFSCIYGFFCGTYFTMMAAVTAYISKMERFPSAFSVFLMSNIAASFGPPIAGAIQSGTNPHSFLSVQLFGGCCFLCGAILMFVLKIKMTKAVFFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q539</accession>
    <name>A0A8H7Q539_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_002486</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q539"/>
    <dbReference type="OrthoDB" id="79252at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15550">
        <property type="entry name" value="PHD_MLL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462:SF3">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="6">
        <location>
            <begin position="71"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="129"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="241"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="457"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="700"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="620"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="647"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="664"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="717"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2186048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="739" mass="80735" checksum="7FC4C8FA24D5D146" modified="2022-01-19" version="1">MSSVKPHLHAQKPSIPIARHRSNTAGSSSSSTASTTSVDLDPGVSNEYSSTSFKEEKSSHDVPPVDTGTIRCICRISDDDGFTIQCDKCLVWQHAFCVNIDKHNIPDQYLCDMCDPIPRYYNVKRAIEHQTKRSQAERKAELEERRGGKRNLSPSSSGSSHRKKPSSDDNSLKRRKRSDGGDKTHPKRPASFGLKRKASDDTTEMWESALKQALSSAFNKADGDSGPDKKQKTGHVTITKYENSRESSPLTPRTVEHTSRFDYEETGSEKQSPVYKTEIKLEEEKANVQDRPSNIAIPTRKLSADSTESINVTSPSPTRTSPPPSIAFSTAGQDASANESGDENVDIDGEDTTTSIQSRSPHTRKKARQNVDSTEASLSPRSPADSDNEYTSDDSNKRRKRASSGNKPSKATLDKYRIVADATTDSTPNSPGLRKLKTLPLNLPCKKLWMRNYLRESSKKISEEQEQPSPKTLEEPISSPLPQNTAENLTEAKQENEAETVVDILGDDKDTIESTMFQDVKESGPPALQENDIFSDNESNASTVPAEDLAERSALLPYAPTASDGPTVPDKDVSLSKISIEDATNDVPHTIDTQMSEVVADDTKSSQSQDQSKTYAELTPDNQQAPNVEQTAPNEPAPAEDAVPVTEQVSLLETANASEEVKQQDATQAENFSEASPSESELEVQPQPKVVRLSVKEYLSQRAAAAQRDEAEKPCSAEQQPSAASPPLTSEPTATADST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5F2</accession>
    <name>A0A8H7Q5F2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_002584</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5F2"/>
    <dbReference type="OrthoDB" id="27911at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000400">
        <property type="entry name" value="Elongator acetyltransferase complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="114"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="457"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="686"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="736"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2186146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="900" mass="99608" checksum="208EF109DBC5F417" modified="2022-01-19" version="1">MVAISAEYISIGCNKITQAAAWGLNGTVAYGANSLVAIYNPLDKNTRGVVATLPGHKDRVNCVEFINRVGLIRICPIGDGLEQTNVALITGSADKTAKIWKLNSLGKWTNSAILTGHTAAIDTLACMRSLSIDSSEGDLVATGSGDGTIKIWRRSIQDENTDNVECIQTIDCGVKYPTALALSYLPGTTIPILATGNTDKKISIYIYQADSNSFTKSLALPGHDNWIRSLQFATYTEGSEDATSKAFNHTLRRNDLILASGSQDKYIRLWKVSPEDSSNHPAIKAEPAAPNGDGSTLTKDMLEALEESVKTGESMQLSTKAHLFDVYDKEAAVKKRYSIMFEALLMGHDDWVYSVCWQRPIAIKDEHGQVKIHQPMRILSASSDKSMMIWRPDPDTGVWINEVRVGEIGGNTLGFYGGLFGPDGKHIIAHGSNGSFHLWQNISSDEDLNHWVPKVAISGHFGSVESLVWDPQSLFVVSASLDQTCRVFAPWNRIIGDDKISTWHEMGRSQIHGYDMQCVSFIDKWRYVSGADEKVMRIFDAPKTFIESLATLTDHKELLAQLESRPVGANLPALGLSNKAVFEGDGSTNANGDEDEYAGLQSYAHPSATPTSLLQTLEHPPFEEHLMQHTLWPEVEKLYGHGYEIRCVRGTHDGRLIASSCKASTPEHAVIRLFDAKTWNELDKSLEGHSLTVTKLKFSHDDKYLLSVSRDRLWSIYEKVEDQSDVGYTYQLASQAKAHARIIWDCSWSHDDTLFATASRDKTIKVWQKAADKNNWVCVSTIKCAAAITAVDFAPCLINEKYVLAAGLEDGNIQLLESQQGSTGEWQMATALDKEYVFLRRFTMTTTHYLLTTNYHLISLCHIGVVNAIAWANQILETPNSLQFASAGDDHAVRIFQVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5P4</accession>
    <name>A0A8H7Q5P4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_002786</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5P4"/>
    <dbReference type="OrthoDB" id="6605928at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2186348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="383" mass="44223" checksum="36A4F5EA761A5E65" modified="2022-01-19" version="1">MDYHLVSVPASGNRQNTLQNLKGKLSEVASTSPFSIPEFKIGTLDALVLLSDELVKYDSSIEQTVMKTVDIMRSLLKDQESQLPEYLKVNDKDPESYVRSFQWNTMKYRTDKSLQETTELLNQEVSSADTVMKNKMNSYTQTKNALQAIQRKQTGNLSVKNLYGIVKKEHCVLNSEYLTTLIVAVPKQSYKHWNSIYESMTQMVVPRSSIKIAEDNEYGLFTVTLFKRVVEEFTHKAREEKFVVRDFQYDETSLEKQKKEAEETMSLEREQQNTVMRLAKTNFSEVFSSWVHLKALRVFVESVLRYGLPPDFAAAVIEPKPKCQKKVEDVLMSQFGHLGGVYGQRAKKGEAKDESLDHEFQNVNDSSYKPWVQFEIRFDPIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5R5</accession>
    <name>A0A8H7Q5R5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_002749</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5R5"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000182">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF32">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="11">
        <location>
            <begin position="69"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="10">
        <location>
            <begin position="272"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2186311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="574" mass="63435" checksum="3EDEC759779CDA30" modified="2022-01-19" version="1">MSPAKQYDAKTPHLNLGTSMPESTRSALGLQGLMPPKVESLDVQKKRALLQLRSKSTDMEKYMFMANLRNTNTTLFYKLICDELEEMAPIIYTPTVGKACQEYSNIYPFLAPIGVPDGLYITKNSLSNLPQILENYSSALSKGAALQPEIAVISDGSRILGLGDLGLNGMGIPVGKLQLYVAGAGIDPRKTLPILLDLGTNNPALLNDDLYLGIKEKRPSDEEFYEAVDKTMEALYKEYPDILIQFEDWSTEHAFELLTKYQHKHFCFNDDIQGTGAVILGGLINAFRLVEKDVPLDKHRLLFFGAGSAAVGVARLICDYFVIERGMSEEQAKSMFWMVDSKGLVRDNRGDQLPEHKKYFSRKDDTGADLKELADIVDVIKPTALIGLSSQPNKFDTDVLKKMGKLNDRPIVFPLSNPASQAECNFEDAMKETNNKVLFASGTAFPPYKIPKTGETKVPGQGNNVYVFPGIGLGGILAKAKHITNSMILAAANGVANSLNEEERSKGDLYPSLKRIRDVSAIVAAHVCQAAEKEKALTNKKLEGKNLDELAKIMKEKMWSPDKNEKEIIEDTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U757</accession>
    <name>A0A8H7U757_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_004585</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U757"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="60"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="62"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2173211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="210" mass="23613" checksum="35A0B0C1873836EA" modified="2022-01-19" version="1">MAYAETHSLPTPASDRAASSPPSDSSSDDSYFNHRKASSISLLLNPKDEPKLDKKPSPTTSTKAKRKRITPDQFSQLMGLFEHNDTPSYEIRDKLASQIGMSNREIQVWFQNRRAKANRAKTNEKIRSAAVLHHPSVPDYGIQFMPVIAPHHHSWRSVAPHTPIPSPGIDLLASAAEYVQREEERLRKRQKPGPHNAISYYHPIPPPNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7B2</accession>
    <name>A0A8H7U7B2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_005126</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7B2"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="24"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="474"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="474"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2173706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="512" mass="55002" checksum="3732C1E086A5FBE8" modified="2022-01-19" version="1">MKLPRYIVNPPLRSKNVKITNSITLITACFATCLDIMNLSAVNIAVPSIASDIGLTSSTLPWLIASYAIAFAAFLLPAGKLGDLYGYRLLYLGGLALFAITSVINAVSPNQYMLFVFRALQGLAAACTVPNAIALVANSFEDEHARRIALSTFAGSGPIGFCIGLVLGGVLTFTIGWRWIFYISAICSLVMFLMAFLYVPNFTHDEGAEKVDIVGFLLVTSGFILIIYALSDGQWHLARDPVTLVIGVLLIAIFLFWETKASSPLLHPSWWSRTNFAVAFAISFIHYATFMGYIYVATLMFQETFGYNALQTALYFLPMGVVAFFVANSVGYLSPYTGTRILIVIGSILAAASNVGAIFFSVELGFWKLIFPMHVLMCLGLPVLYVGGQNAMIVAAPPNETGTLGAVYNTAGQLGSGVGLAIMTAAIDGVNAPGATGTDALPGYHAALYVNVALLAILAIVSAIFIKDDRKKVNKETNPERVSNDLEKGTLEKREGTEHQENDNESSATTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7M5</accession>
    <name>A0A8H7U7M5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_008150</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7M5"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000263">
        <property type="entry name" value="MAP kinase skh1/pek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF5">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINAE MKK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="91"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2171770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="372" mass="40617" checksum="AE1B962D1639429E" modified="2022-01-19" version="1">MSKLSRKPAALRLAPITLKASASATTSGSDSLQASLSLKPSHSFESTCSWKEDIARITHDNSSDPSPNDSTASATENGSTRQFGELQPEEFENIKKLGEGASGTVMKVLHKPSNVIMAKKTITTDPDPDVQRQILRELSFLKTCHSPQIVSFYGAFLDDGDTSIAICMEYCEAGSLEDIYKRAKDLGGVIGEPVLAKIAESVCLGLVYLHSKQVIHRDIKPSNLLVNKAGNIKLCDLGVSGELINSLAQTFTGTKYYMAPERIKGSQYSVQSDIWSLGLTIIEVAQNCPALPPPGQPHLSIFELLDFIVRQPVPTVSSDRSAECSDFVATCLIKDPADRPGPKKMLEHPFIQQWQGVQVDIASWIKEVWGWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7X8</accession>
    <name>A0A8H7U7X8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">KxDL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KXD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7X8"/>
    <dbReference type="OrthoDB" id="10258877at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039843">
        <property type="entry name" value="KXD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019371">
        <property type="entry name" value="KxDL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13511">
        <property type="entry name" value="KXDL MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13511:SF0">
        <property type="entry name" value="KXDL MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10241">
        <property type="entry name" value="KxDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KxDL" evidence="2">
        <location>
            <begin position="45"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2172385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="136" mass="16109" checksum="14643DFAB6EE5F61" modified="2022-01-19" version="1" fragment="single">MSAKAEWAKRLNCKDDETLEKVLREQEESCVLLTHSSDLLLSLHLVKKTTDQITAFNDFSAARYAQVQKHLEAHTRLLKEIKVDLDSAFRKIRYSESLLVMIYRRIMWFNIDYLYLSTLKKHCQEQHPTEHEEALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8B5</accession>
    <name>A0A8H7U8B5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8B5"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="31496" checksum="6FD2809DA8AA6EFD" modified="2022-01-19" version="1">MERQLFEVKKKGRPISQCPTCRLLRKTRKMHNKCECDKAQSPADYTSSSSPPSPIQPTPVHHSLYASSNGRPYVDDLQKIQPPSIAARPLIPNANTLQQSMLHHFATVVTASVELSDKDYGDIPLSNVGTADTPKASCCSKAKTEKKDENTEKHCCGSQITSADNKHTNVLEPCCTNNRPCTSSKHKHSEKKSRIVLVTCRCGDDCACPGCDVHPSKVMKGKKDPYAGYTSTSIIGEATVVHRKPSLDDIAGEDWKSPTAVFNEHGVMLCGCGCDRPFDSCRGCGNGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8C7</accession>
    <name>A0A8H7U8C7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-alpha-acetyltransferase 40</fullName>
            <ecNumber evidence="4">2.3.1.257</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_008197</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-seryl-[histone H2A] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12742"/>
            <dbReference type="Rhea" id="RHEA-COMP:12744"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-seryl-[histone H4] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H4] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50596"/>
            <dbReference type="Rhea" id="RHEA-COMP:12740"/>
            <dbReference type="Rhea" id="RHEA-COMP:12743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. NAA40 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.257" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8C7"/>
    <dbReference type="OrthoDB" id="424551at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043998">
        <property type="term" value="F:histone H2A acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039949">
        <property type="entry name" value="NAA40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="12">
        <location>
            <begin position="41"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2171817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="212" mass="24630" checksum="AD2D3E23E3EAC054" modified="2022-01-19" version="1">MPTQPSGDSNNKVAAANRVKSLVDGINLPLKYERDDWQVDIDYYHIDDLPDHLRDWSFQTFKENMLTLYTNSNDGWDAEQKKNEMFAKEARYLIARSRQNPAELHGMLLFQMVQEETMDDDTLCNAAYCYEIQLKETARGKGLGEYLMKLLENIGKRWQMDKVMLTVFKANKGAFDFYIKKLGFELDEISPGACLPAKKARLFDYEILCKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U974</accession>
    <name>A0A8H7U974_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MRH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_004358</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U974"/>
    <dbReference type="OrthoDB" id="4504960at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000479">
        <property type="entry name" value="CIMR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00878">
        <property type="entry name" value="CIMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01404">
        <property type="entry name" value="CIMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034458101" description="MRH domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="5">
        <location>
            <begin position="23"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="208"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="780"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="325"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="451"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="506"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="568"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="630"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="811"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2174335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="829" mass="90571" checksum="65D19BC73D48BE10" modified="2022-01-19" version="1">MRNVAWIFIVILAAGTVLAQDANTCTTKDSKGNSYDLNPLKHTSSETDWTFHDPDSSMEFRLNICGELQEKNTGLMHPEGVGAFTKERSESKGYSIGQYSEKPFFRGDKLMLKYTEGQACPRDSNAKRSTLVSFICDRGVSDMNKLKIAITGSSGARLQRAPYAKKALLEYGRQYGRLVVKAGPPFDETNAGAEIDTADDAGKAIADNADAVSSDDGEEDDVDNEWAGDNDKSVDEFGEPVSVSDDADEEMADKDDEEVSDKEMAVEDNVDWGSEDNELEPSAEELNDSADEDNTEDPFAKEDIEDAAEGSSELEDEKDSFALGSEDDETTTPEAEPSDEEDSFDAGTEDEETTTSETEPTDDLDPFAMDAEDEEDTGSSTEDLVEEDPLASEDDDMEPTSSESEETDDADAFAVNDKDDVGKVAAGDPEENEFGYDENESSTPTENVAGADDDTEGATEETETTETLETSDAEDSEFPEKYPTTGLDDDQVDNNTEESISPEEILTADEDNDPEEEINDDGTIEVEDDSSDNNEIDDDQNETSDKDDDFETTEDDLTEDGFDKTVSDDDDDDEMDEDNGDDAAVDTEVADEAPENPNAGDETSEDPDDPTGASVDDEPSEEDSTSIGHGDQDETKLDKVQQEDPDVQPAAGHTTHGTSETVQDDMDTDTAYPGANDNGYDYTQYGSTYGSSHVQYQGAILIAAVGVVGLFMVKRSRETIIQGVQKLSGRQSDQGQYSHLPLNATGKLQFLSDKNVDTPNHNLSNTTSEWAVDMSNAIDHDHQDESKPSRGMKLSHSKKASQTNSIPLKPVQDRKSQEWADWKEDEEDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9G4</accession>
    <name>A0A8H7U9G4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_009090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9G4"/>
    <dbReference type="OrthoDB" id="4080456at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="261"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="400" mass="45910" checksum="AE7495EC25D39B59" modified="2022-01-19" version="1" fragment="single">EILRNTSQGDIDVLVKNEDDSVVTGRTRSSIRKECEANMESQLSGPIRDMLSSSHEVDSGFAQPKKLKAPRSSYGLPSMSQQQEWAVLQKLDRTTQALPSQVARLRRKLHLRRLKRSQGAKVFDLDSYLNSHFRSHQQLSAMPSETLKAFATPKKKDAQKPLSNQLEEEFEKLKSITHTPYANSFASRLYGTPSCHNTITKTTPWLSPWNGRKLRPYIRRDYESKPTAMRLLHEIRSAAGKPQKSGKPINIDSDELRSDSIDYVYFQKEHLEQVNRILCRTFWDGVDVGESLLFPEFSIVALYKRYVVGCAFMTPEAYVTYITVVPGWEKAGIGQFLLYHLFQTAISKDITLHVSANSPAMILYQKFGFKPEEFVINFYDKYLSPESSYSKNAFFLRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9J1</accession>
    <name>A0A8H7U9J1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9J1"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="1">
        <location>
            <begin position="55"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2174710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="188" mass="21457" checksum="F00DE5AFCA844D35" modified="2022-01-19" version="1">MLCTATPNNQYFTPLSPTVLQHRLPQSLTDYFAQIICDLLPTSSPQTRSSLVSLPELLFFIEKVTHRAGVTCKVIVYAMIYLERAKEALPKGAVGNYDTTHRLFLASLLLASKFLEEDMETNLNDSPISSVPRLNGKRLRDLCGGIYTLKDINTFELSFLKLIKYRCWVDQDDVESFLRRNSVELQLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9J9</accession>
    <name>A0A8H7U9J9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitin synthase export chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_008260</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CHS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9J9"/>
    <dbReference type="OrthoDB" id="2189463at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF2">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2171534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="327" mass="36675" checksum="2865BCA1CAA58B26" modified="2022-01-19" version="1">MSIISNSFQAFKFDGICQTVALSLCPLIGKYDGIEPVCYSRNVDLAGTLIFQPATLIIDVVAIVMAAIMIYHIKSKYTAVGRKEIVMFFYLYMMTTFLEMLLVTGIIPTASNVYPASWFTAVHIGLMSATFWCLLLNGFVGFQFAEDGTPWSLWSIRISSFFVFIVVGLIAIATFNNLGPFSYANPGVLWVFYFIVNGAAFLVYVVLQIVLVVNTLDDRWPLGDILFGAAFFLIGQVIMYFFSVAICDQVKHYVDGLFFGTICTLLAVMMVYKYWDSITKEDLEFSVGSKQNVWEVKELLGDDDLQSHPGYNSPPMHPHAAQYQDNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9U9</accession>
    <name>A0A8H7U9U9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin cytoskeleton-regulatory complex protein SLA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_006087</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SLA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2175025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9U9"/>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11773">
        <property type="entry name" value="SH3_Sla1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.700">
        <property type="entry name" value="SLA1 homology domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056996">
        <property type="entry name" value="PH_SLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007131">
        <property type="entry name" value="SHD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035800">
        <property type="entry name" value="Sla1_SH3_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24081">
        <property type="entry name" value="PH_SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03983">
        <property type="entry name" value="SHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="2"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="300"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="366"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="676"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1117"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1232"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="372"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="416"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="493"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="714"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="750"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="792"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="856"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="896"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="907"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="927"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1123"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1232"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1255"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2175025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1267" mass="140570" checksum="ED990898020C2486" modified="2022-01-19" version="1" fragment="single">MKYIDVCRALYDYEAGSEDELSFKEDDILYILERDDEDWYKAQLKLQQPDEIGPVGLIPANYVSEAEALGAVSALYDYEAQQEEEVTFGEGDTMVLYDKDDPDWYLAATEEVTHNNDQAVVGEDETQPSVSVFSALSNATGKPKPKLINDEAQSWPVHEYDVEKKKKKKSKGNLLVGNGMLCYGSETDKASPVRQFPAKDIVNYSQDSKIVHIEIAGAKSATLDFQASSKSEAKAILAKIRSSKQASTAFESATAAAAKPLPTSLPQHAPQEEQVYEDAYEEQPQEEEPQYAEQPEEPPCEPRWAIVLYSFDAQGEDEISVNEEDQVLITDYVTSDEWWKVEYEDGRAGVIPASYVQFQEDYEAALQAEEEQQQREQEEWARQQAEEEAARAAEEERKRKEEEEAWQRQQMEEEEKERRRREQEESRRREAERRRQQQEEARQKELDEKKRAARAAVPPPPPPSAPAAQPPRRNQIPAPPPPPPVRPPANRSLPSDQAVNSISVPSSRSLPDRPKQAQNPGKPDPAKTRTWTDRTGSFKVEAQFLAVHDGKIRLHKINGVKIDVPIGKMCVEDIRYIEEVSGGGTTEDTSDNMPLAQLAKDNSAQRQKAQAGSSNQSWDWFDYFMKANIPMQESLRYSSAFQAENLGENDLQNLTHRRMKSLGLSEKHVQRLQRFIENGSPEPPSDDEVAAAKKAKGKRNVSFGETSVIGEDGGDTRQKQIEEDERLARELQEQEDSTKSPSIFKKKDNNTSPSLQRRGTSRPTPANSAPKGINSDVFELMKGQLSTEPLQPAKAAPATASPSKETATASTNGSHKSQASGGFEDDAWAPRQASPVVAKKSEPAPAPSPAVAPSPQVNQPNFPSAWPSQQQHQQPTGLSPAVQPASSFQPPNNVQAPPPPPPPPVMPSVQQQQPVMNSPARQRPIPKQSQDSKVNSQVFSQWNSPGNQTINQQPTGMNMNQNRPPVPMQQNTPTGNFQPAPMQMQPNNTFVNNQQPINTNMQQPQMQQQQMQQPQMANQQRPFIAPQNTGFVPQQQQQQFMSPNQPQMTGMQRPPSMMVNNMNTGQGLQPAIIPANTGVSNMMSPPQNMQQFQPLRPQQTAFGTFNNNVGRPNPAGNMPNMGIQPQPTGQRSWANATPDNPFGASPQMPGQSLNQTPGMQPGQQMNIQPQATGFMQPQQTGFGNGMMGANGPPGGFGNTGDKYSIFKAVDPQSPSVFNGAQPQQNMMGQFVQPQQTGFQQFAQQQPGNFQNNANTGFNQQNQQSYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAK1</accession>
    <name>A0A8H7UAK1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GDP-mannose transporter</fullName>
            <shortName evidence="9">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_000218</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAK1"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2172868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="374" mass="41358" checksum="C8E1A05321BDE9D1" modified="2022-01-19" version="1">MVSEKTDYKVVIEDKDSNESISSQPNSNVTAPSIITLSPGARAALPIISYCTASILMTVTNKYVVSGYDFNMNFLLLAIQSTVAVVLLEGFKFLNLIKYRDLDWNEARNWFPIAAFLVAMIYTGSKSLQYLRIPIYTIFKNLTIILIAYGEVLWFGSHVTQLMLVSFILMVLSSVIAGWADVSATLSELTQLDHTIIGYVWMASNCFSSAAFVLFMRKRIKMFNFKDFDTVYYNNLLSIPLLIIPSLLFENWSSENFAKNFPETVRTQLIVAMVFSGVSAFAMSYASAWCVRTTSSTTYSMVGALNKLPIAASGIVFFGDPATFGNITAIIVGFFAGLVYSYAKAFPAKSDKPQNIPMSSSSQSVTDATKANND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBQ1</accession>
    <name>A0A8H7UBQ1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_001349</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="PAC" evidence="14">
        <location>
            <begin position="932"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="13">
        <location>
            <begin position="991"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="14">
        <location>
            <begin position="1065"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="1135"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="1698"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="146"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="510"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="620"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="710"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1387"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="511"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="547"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="629"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="650"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="715"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="803"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="858"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1387"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="1750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2175702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1837" mass="203898" checksum="F285BD311642E8A7" modified="2022-01-19" version="1">MQQGPSTVNVSNMSDQHHDPDGTTQHIRKSSSSSDPLLYARSASQYHAKLYNDHQQRSTSSDERQSPPQLPPFQNVMLSFEPPNLYKTALQLSSEIDLQNWWYSVVDVLSNSSFHASRACLSLPQDPSEPYHSAWGVKAVHSRAEFPDSAESDSVDSTNNEHSDDYFTKTERKSVDLTDASQEEEKPNIPTLPLCFESLQPFDRDEEPLIDKNSIDRIIRRGTTVVLSREYRHNQSSDPLQVGESSQQIGSGMFKRTLMERLDSYHHHHQLHHQQNAPPGAQMQQQNIERNRNEINSTSRRHSAMSTLPQTPTFDLACLNLQASDDNCKFGDSEVLPHSDSSGAESTLNTQTGLQPNVDLKRDYVFDEYEQQQPSPWSQSPAPSPAMMDPNVNPFFTTALTIDDDAFNPTSPESYESSNVSYPMPVGNVHSIVHIPIYHQTGRRNSGKSLHAEAPFAILSFLSAVVPYPQVMISCINSLVPFIATSLSNCLAHQTLSRQAFYYRHQDSGHAATSTSTDSPSKKLTQNISPESASSNPLSPEHARQYTATDTDSATPTPTANGAYDKRGPFSAGGMAMLHKNAFEAIDESKAPADDTPPNYDLDYDNNTKSIVQMTPSCEQPSFLPAHINTKDESPTSKSGDHDTNSSAHPYSPTSSRSASPLSSAIRHGWDAISPTTGLPIIASIPPSSIDKWRRLSSSSSAYESDVGVMSTAESKSPGSVQSPGSVKSVKSSSTLSPSSIRSPASIKSPATLSPSSIKSSHSCISPSPGISPTLQVKGQTALPATPDIPTINEDTAMPPPSGEDDTLAGDEADEPPDKPRNKIKRKQYAPHGVPSVPSTVEGGPPPEENTIQLSEKSSSKEHKRDTMIMPRSRLLRLIIDGIPIHVFRVMQYSGLGMKDHVGSRWLSHMHPDDRAACKRQWKAAFEDGVGFAGQYRLRRFDGDYRHFLWRTVPLRDTKGQIINWFGTCTDIHDEQIAKEYTIRQMETEHNERKYRLLAETIPQLVFTFSPEFGITYANQKWESYSGQPLEDTKGLAFMEQVHAEDRYKLRLPDLPDEGDVGVSWQEEVRLRSKDDEYRWFLIKCISVQQNEIPDARWFGTGTDINDQKLFEQKLKEAHDAAQKSTESKTRFLSNMSHEIRTPLIGITGMINFMLDSDLTAEQLDYAHTIQQSAESLLVVINDILDLSKVEAGMMKLEMEPFSLLGMVEDANELLSTLAIQKGLEMSFWVDQEVPDVVVGDRIRLRQVLLNLIGNAIKFTSAGEVFTKCSIHQPVNDSNEIMLMFEVVDTGSGFDSEGEAVMFKPFSQIDTSSTRKHGGSGLGLVISRQLIELHGGTVKCSSQKGEGSTFYFTVKFTIPSNTTEPKPQTPQEETIKSPFFRSSAYSVNAQSGGSHQPFHQPSSSFENPSSFGTSSPLEHSIKHSQLDGLTSASRLQEALLYKNAPPGGLLPVGVQMNPEVTSDFAGAIKKRDLALKISKELQLPKAFRTSAEDIPQAIEESEGEPTIVVHPAAPICPRALVISEWLYSKNVVVEHVKTLLQDKYNDATQLDVCNSHVEALQMLTDPDTKPYTWIIINLSMQHHILPLVRHIACSPVHQDAISIVLTTHLQRTTIFDGAANENGLFKKCEFIFKPLKRSKIDMLFPSPNEPVRQPSLSGTLLSQMTPRRHVPSVQQQTVAGQQEVFRRMLADVGNRGYHVLLVEDNLVNQKVMIRYLQRVGLEVDIAADGCQCVDTVMSHPHGYYALILCDLFMPVKDGYEATHEIRQWEASLNPRQPPIPIVALSANVMSDVATKCKEVGFSHYISKPVNFTTLSQVVRGYIKEYESNQAHKNKQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBQ9</accession>
    <name>A0A8H7UBQ9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBQ9"/>
    <dbReference type="OrthoDB" id="2377025at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="221" mass="25677" checksum="22657DA350A54ACC" modified="2022-01-19" version="1">MTTFRYISVSDYDYVLHLSEHKLTKYQYQRTEVGLLKHVLIRNLLIKAHTLSPDSDEEECEEDEDLTDQPLTFGSSQNTPAVSVDTERSKEENWFETCFDQLDQDTVDSVIIDYSSGDEDDEDMEDGTVPRWVQDIREKYHMSHENKGIQFEDDEADEEDDESNDILKLASLESSCDYFLQNDKTCSLGSFDPFAGDDVVQDTSFDNKYSWIKWRNDPITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBX6</accession>
    <name>A0A8H7UBX6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_003703</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBX6"/>
    <dbReference type="OrthoDB" id="5273213at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000016">
        <property type="entry name" value="Tubulin-folding cofactor E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15140:SF6">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE COFACTOR E-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15140">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="8">
        <location>
            <begin position="28"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2179916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="542" mass="61948" checksum="29D9E402CC22AC1C" modified="2022-01-19" version="1">MPPKVPSCLMLGDRIQVDQDLATIRYIGPVDQTDGEWLGIEWDDPARGKHNGHKNGRHYFSCRQEGAGSFIRYSPKRIHIGVSFLTALKDKYLPSNPELLQKEYDPRQDKGHIQFGGNTGITVETVGFEKIERKQCNLQTLAVAGLKLTRVSSEDLPLEIANTCPNLHDLDLSRNLIVQWEIVLKIISQLQKLRVLWLNDLRMDVALNARIQSYSPFASLKILSLKNTAITTEEIRHLSPILINLEELTLSSNALEDIDIVSDDYSSFQQLKLVQVEENNIDSWDKVLKLSKLPRLEQINLNSNKLTSIQPRREGDFPSLRYLHLNNNLISDWKSIDALNFYKTLEHVRCKQNPILEGIQVYLINVQLVGRIGSITRANGDTILLKDRIDMERYYLKLCTKDGATDSEISQKHPRFIELCNINGRPIVDKPEENESSALKNRLLNVKLCHRNGSAEEMLKVQSVEELPESVKLVEKRLLGTMSIRTLQNIIQKLFQIPSSNQRLFLVQKSQQSSIAVQEIDDSLRELKYYDLQSGDEITIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UC16</accession>
    <name>A0A8H7UC16_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_004406</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UC16"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="33"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2174383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="201" mass="22918" checksum="B96E84BBEFAFEC50" modified="2022-01-19" version="1" fragment="single">AVSRNYLNTKIEIIQSLALLASQPNFAANSYTAWMYSGMAVRMAQDMGLHRSISKWKMGEAEAEQRKRIWFSVYAVDRWCCAAVGRPLAICDADCDIELPQLCLEEGLDSKSKRYRMLFRNMISLSVVLGLILRQLYSPKVKSLGHDSTAIATMVSRLKTQLADWYDQIPQHCKLDDQDIARIRQAKTEPLEAELKEKIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCF1</accession>
    <name>A0A8H7UCF1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_005662</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCF1"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19147">
        <property type="entry name" value="AKR_AKR9A3_9B1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000024">
        <property type="entry name" value="Aryl-alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF2">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="31"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2176422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="383" mass="42726" checksum="E6B850F287AB636F" modified="2022-01-19" version="1">MAELFAPAPEPATELGRYRILSSTAGIRVSPLQLGAMSIGDAWSGFMGSMDKDSAFKLLDAYFEAGGNFIDTANNYQNEQSEAWLGEWMTARGNRDQIVLATKFTTDYRSHKMGKGKVPNNCGNHKRSLHMSVRDSLAKLQTDWIDILYLHWWDHTTSIEEIMDSLHILVQQGKVLYIGFSDTPAWVVSAANYYARANGKTPISIYQGRWNVMSRDFEREIIPMARYFGMALAPWDVLGGGKLQSKESMEERKKRGEGLRSMMGGEQSEDEIKMSEALSKVASEHGIKSVTAIALAYVMAKAPNVFPLVGGRKIEHLHDNIQALKIKLTDDQITYLESILPYEPGFPNTFIGEDPKVTGKFTFLTAANAPLVIERSPKPIGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCU9</accession>
    <name>A0A8H7UCU9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sphingomyelin phosphodiesterase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003518</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCU9"/>
    <dbReference type="OrthoDB" id="348678at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045473">
        <property type="entry name" value="ASM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF55">
        <property type="entry name" value="ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19272">
        <property type="entry name" value="ASMase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sphingomyelin phosphodiesterase C-terminal" evidence="3">
        <location>
            <begin position="249"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2178265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="334" mass="38508" checksum="9DB99F70E0A858C3" modified="2022-01-19" version="1">MDFIIYTGDTARHDRDKQLRRNNSEVIESHKAAIRYFNSTFDLNKTKLFPTIGNLDTFVHNEIQEASRDQLSRSLFQELYEIWEPLNLDLQSTFQEGGYYAYDMPDGPTVISLNSMYFFDKNYDVEDCDTPDSPGAIQLVWLEAQLVKAQNNHRPVYIMSHVPPTERKKLYHPACYSAYVNILGKYSETIAGHFTGHTNDDTLSVLYKTSNSKPSSPFALQALTSKSQLNFKPQDVINVLTNAPSIIPVNNPGFRIYRYDVKDGGLFGWDQYWADLNEGNADGEMTWKMEYSSRDTYGVNKLNKLGWQKLVQNLKTKKKTFSKYSTYVKVLRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UD54</accession>
    <name>A0A8H7UD54_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258608at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000002">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056604">
        <property type="entry name" value="GBF1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23325">
        <property type="entry name" value="TPR_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="639"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1323"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1572"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1333"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1582"/>
            <end position="1597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2175553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1644" mass="183585" checksum="DD5925C5755B9DDD" modified="2022-01-19" version="1">MASNSLAMELPRPQSPQVPQQAHVSLYGGDYPKCELTWPQLIHAEIIAVTSAMRKNSRWSGISVSGLNMGSLGMSMGLRTGLAGGKDSNYRNQESPLMHGFTNLRTYLTTVRDISELDASMLLTPFLDVIRSGNTTGPIAGAALSSVEKFLQYGIIGLSSPNIAVAMGNLASAATHCKFEASDSVSDEVVLLKMLQVLQMALICPCGSVLSDEAVCEMMETGLSMCCQMRLSEMLRRSAEHVMINMIMAMFERLKLIQDEGDMEAEVDNNQSNEESTAARADPHMNTPKTFASPSLSEAEKLKDSVMSPAKDGSPILENGESKSSELKRDEDSIKNVVDVALNVGTQEATDDIVEETDVIPVPYGLPAIRELLRVLISLLNPHEHKHTDSMRLMALSILNVAFDVGGKSISRFESLRSLITDEFCKYLFQLAKTDSIPLLTLTLRVISTVFDTMRPYLKLQQELFLFFLIERLTRTGTTNTGITYNIDEEGNVNFVLPNTDAIRDGRESGYVDVRSASPSLGGRPADARSVKSNSESSLYSGEVRELLLECLTQCARIPTFMVDLWVNFDSDISCGNLFEELIHFLSKNSFPEPNSYSASNSHMLCLDALLLFISHMVDRVSEDDTFADAASNFIQPSELLARKEAKQVLLEGASRFNDSPKKGIQYLKEQGVIVEDANGDFTDSLAHFLMSTPKLNKKSLGEYLGHPQNVPLLKRFMRQFDFSNKRVDEALRILLETFRLPGESQQIDRITETFADAFIESKPEEVANQEAAYVLAFSVIMLNTDQHNRQVRHRMSFDQYKSNVRGINAGKDFAPEYLQAIFDAIRSDEIVMPEEHEGQLGFNYAWKQLLQHSKSAGLFTVCNTAAYDKHIFQLAWKPTVAAISYAFNTAQDDVTLQKAITGFHQCALLSAHYQLHDVFDSIIVSLASMTGLVDNEETDLMAPDPIVDVAGQKYIVSRLAVRFGRNYKGQLAAVVAFAVASEHGSILRKGWVKVLRMIKNLFINSLLPSSMLQVEDFLVGTTLIPLKPKSSPPPKQQTRKDASLLSTLSSYLLSPYSGDESYRADPTEEEVESTMCAVDCVVACRLEELFSDIRFLGKEPLEYLMKAIRTIGYKTVIDESTTPIIYDPATIFFLELMISITIQNVERIDAVWPYMYDYIAGILEKAGNQSVLLLERTVVGLLRVCICVADKVNKFGLYHTCKHLTYSNAFYEQPSMQKELENCFKLLLNLPDAVLQAVAEQTMAGILNLLKLDSPQVISCWSFILDLVQSTAGHADASNYGFESAVYILTYEKGSHIIDTEQFNKLVNIFSAFAAVAAPTSPAKESPARTRAAQTPKSNKSPQISIERGKKSIEHIFQLHQLIPRLSQNKSPNEVWDCYWQPILTSLSQQCCTACREVRQYALTFLQRTILLSDITKYEDEDNMDRQPWVNIFDNVLIPMLSELLRPEVYELDPLGIDEARMRASALLCKIFLHYCSRMLEMTAFIDIWMEILDILDGSMHTSENDHLAEAVRESLKNMVLVMYTSGAFTNVPPHDVPAGMTPEYNHLWDLTWERLDGFMPKLRELFPAAPTEPVAEESQPEVNTHQSEANSQPEFNAQPELANNHVEDKISTNDQHSNIPPLQETEDNSSEIIDASSTVHAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDR4</accession>
    <name>A0A8H7UDR4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_002075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDR4"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000020">
        <property type="entry name" value="Guanine nucleotide-binding protein beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="58"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="146"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="280"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="315"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2179225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="347" mass="38325" checksum="8F54AEF4478FA73C" modified="2022-01-19" version="1">MNNNSDIAERIATARREAESLKEKIKQKKDALADTTLRQMAKDVEPLPRVVMKVRRVLKGHLAKIYSMHWSADKRHLVSASQDGKLIVWDAYTTNKVQAIPLRSSWVMTCAYAPSGNFVACGGLDNVCSIYNLRSRDGPVRPARELSAHTGYLSCCRFINDRQILTSSGDMSCMLWDIDAGIKIEEFNDHTGDVMSLSLGPNPNVFVSGACDATAKVWDIRSKRCVQTFTGHESDINSVQFFPDGNAFGTGSDDASCRLFDLRADRELNQYTNDSIICGITSVAFSVSGRLLFAGYDDFTCNVWDTLKGERVGVLSGHDNRVSCLGVSSDGMALCTGSWDTYLKIWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UE76</accession>
    <name>A0A8H7UE76_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_005433</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UE76"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13994">
        <property type="entry name" value="STKc_HAL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="166"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2176199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="457" mass="51541" checksum="955590DAC5188533" modified="2022-01-19" version="1">MAASSLFAQWDSRPSLDLSLELEDPAISLDGARSSSANSSPKHITPIVVEPPQRAYMPQPNIKRKKSLKSFGLLRHDRHSIQLEENSPSPKPTPKASQSSGPQLLKVDQATKVAGRRPSLTSLLTSLRSTPNPASSDESFVTSPASPNPGSSPALKVPLLYEKYGVCQDGNVGEGTTAIIRLVRRRGHDTVLAVKEFRKRSRNELEKQYMKRMTSEFCISKPLNHENVIKTFDLVKDDRGRWCTVLEWCAGGDVFTVLRDVDLSDEEIDCLFKQLVQGVHYLHSSGIAHRDIKPENLVLTATGTLKIIDFGVADVVQSCFDKTSRRSAGYVGSEPFLPPEVFTDEEYDGRALDIWSTAITWYGLQFRAIPFEKATKDDHFYKEYLSARRQRNWPPLIRCTPQERECLYGMLDPDPSRRWTIEQVLQSTWLDEIETCNFAHTESGVEHHHYIKATNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEJ9</accession>
    <name>A0A8H7UEJ9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_007677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEJ9"/>
    <dbReference type="OrthoDB" id="2384637at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024368">
        <property type="entry name" value="Ecl1/2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12855">
        <property type="entry name" value="Ecl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2177023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="87" mass="10063" checksum="760D2C9B5F56A7F7" modified="2022-01-19" version="1">MCDLNWCPVCDNAISPHSNSLYCSQKCLQKDALQNHPYFGYQYPDLLPFKPRKSICNLSCTMRYHDPIRYPFKAAKHTSDKALIGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEL0</accession>
    <name>A0A8H7UEL0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEL0"/>
    <dbReference type="OrthoDB" id="899at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF115">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="2">
        <location>
            <begin position="11"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="108" mass="12022" checksum="7F65C9FEE0D4F6DD" modified="2022-01-19" version="1" fragment="single">YHSEAPKDTPFTLEQLKDFDGSDLSKPIYVAIKGTVFDVSKKPEMYGAGSGYNCFAGKDASKALGKSSLVPEDCVADYSSLDEKEMKTLNDWYAFFEKRYNIVGKVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UF75</accession>
    <name>A0A8H7UF75_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alcohol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_006537</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UF75"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05188">
        <property type="entry name" value="MDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401:SF2">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="3">
        <location>
            <begin position="25"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="2">
        <location>
            <begin position="182"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2183531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="38372" checksum="58171ADB1DA05819" modified="2022-01-19" version="1">MKAAVLTERTPELKLQDVPDPTLTPGSVIVKVLATRLVHYFKQVFSAQRPYPIQLPLIPGCGAIGIVEEVGRDSSAFKKGDLVYCDCYIKARDDPFEPEDMLSGLLCPKGNLSSVYRHGSFAEKALYPVENVTVIPKAVGREEDAAKLTSINLLLVAYGGILSGNLKAGETVVILGGTGYFGCCGVVLALAMGARSVIVPTRSVDKAKLLQDRFGERVVPVITSGDEKEDEQAITKAAQNNYIDLVLDLLDPQAPLAILRSALCTLRADGTMVLMAGSAENIELPYFSIMKRNITIKGCFMYPRTAIKSLFGMIQAGLIDLDLFTVTGQYSLDEINEALTFAEAQGGAFKTTVVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFM1</accession>
    <name>A0A8H7UFM1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_003658</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFM1"/>
    <dbReference type="OrthoDB" id="39734at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF56">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="334"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2179872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="569" mass="63126" checksum="B8A3E676D39A7F45" modified="2022-01-19" version="1" fragment="single">MFGAIISIGEKETPILSNAPAAKPDKTPKIVYLRDYSHIIESPIGELVVTALLQTIQDLRNQSQEIVAVAGVSPSITTLASRKNLFHGQSANNKVIDALPDMQDMEDLLGNKIKFPYFQLVSIPPDMNSTSDVETWREQMKRDLSRRVQEINARNVLTVCIQKSLLSPAQAFVSTPSVTKILAKIESSQTDYWPMHFVQRLVATAVGISLNQKGRDVNGKPLNMSYLVEAEKVLTTGSDLRSQALSKIKGETEAARKKLVSVTEGKELDLKALKEMCSEHERKLLTKIIDPARIKTTFDDICAPATTIETLQTSISLPLIRPDIFSYGILGRSFTSGMLLFGPPGTGKTMLAKAVAKESGSRMIEIQASDIYEMYVGEGEKNVKAVFSLARKLAPCVIFIDEVDSLLNARRSDFASNTHREIVNQFMVEWDGLSSDNHGIILMAATNRPYDLDDAVLRRMPRRMLVDLPNEAERAKILSLHLQGEQIDPQVSLTKLAKETEYYSGSDIKNLCIAAALNAVKENTADIFKSIKNNQSKGIEEKESIRVLKQHHFEKARSQIAPSASEDMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGE3</accession>
    <name>A0A8H7UGE3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGE3"/>
    <dbReference type="OrthoDB" id="2413485at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="225" mass="25660" checksum="0F9F023F0B80DD70" modified="2022-01-19" version="1">MQKQQPLTPTRRNTKESNTENAESPKQPLATITNRITSRKTGIQSKTSSPVTTPKSSRLSTYTPGSPDCFIPASPLSRRTLDVQDELFKVYKDSLPSPEQPRNRRSSPSEVDDSLTTVGSDSVLDRLSRTTTDAQIIDLQQKLDLQIRENEKLRKELHEEKFQRQALEEDHKLQDEFIKALEKQLSEIKLASDNKCQSLEKELAESNELLEECRSLLLEVHQEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGP6</accession>
    <name>A0A8H7UGP6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">INT43_008594</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGP6"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF8">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="50"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="208"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="758"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="808"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="821"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2181012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="831" mass="93435" checksum="B474F26624BBC93C" modified="2022-01-19" version="1">MSTNEVTRNGMAKRKTSLTLSPKAMGIDSDSAAWANEVKSPPSTHLEQSTTPGSVYSVSSQIEPPTGTIRIILMNVFLNRPIKHPYVLIRYGDRVFQTSTSEVPEGQWNEGFEFQISYHAQLFDSIQLDLYDESYILLPDRHIGRAELRLRHLEGMPTVFTNYYEIWDKKQASSNVSVITQKRNLASNIGAIQCRIYYRYQDANISSETNSSLRNGKSSFMGTSDDNLHRRRGSSASRHQVAKSAAMLSDQQIGDEFRKHLQTERRTSQGSFHFQKYEEKHDGELKNMNDIDAEADEQQFETDDQQSWFSSWFNAGSTMPSASTSSSSKKEIKEEKGKLSSLDSESNSSLLDTIASWSTSKETGSVLKSISKLLSAFGQGFELSNYQIVTGFAVLEKFYTELPRERTWDVVKNLDDIDLASRFWTFAVAAYGWRGIHFLGKGNGIWADGLRSQSDMLSVANYLKIADEDMLAYEWRKSEVFRPSYFIAKDRATNSIVLSIRGTMSTFDTMTDLACEYEQWKGGLVHAGWKASAQWFLQEVGPTLIAYANVHCTSALYVVGHSLGSGTAAILTIMLIDYLDEFRKEQPDFQIKCFGYAPTCAMSLDLCERYKDFIQSFVFADDIVSKLSYGSMLNVKEMLLVSAEAAQDLGISKIFWTNTPQGEEWEKAFDNIAEVRRRCLKSNDHPRLYVAGQVFQFWIDPAPGKDPTRIVIERSDARRVSGEVIVRRSIILDHIPTNFDVAFTRAREALMLDHLGSTTTDGTLRPSLEEKQGGTQLDDNVQRASEESNKSVLDGLWSTLAKVGLSGTTQVEGGEGHAMNRSEQGNGQLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJL9</accession>
    <name>A0A8H7UJL9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_007140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJL9"/>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="199"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="18"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2182213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="267" mass="29690" checksum="B7236BD3DBB011BB" modified="2022-01-19" version="1" fragment="single">ASDAELAKALHTWTVNNGIEGHGAFTDDPKSGFRRNRNIYRSSIPGTVPETDERSGGTSNNNANIVLSMYDNENGSQSAGNLHGSQTYSPLLSPKASSRPTSRSQSPAPRPSSSAGLVPPSPRGWENRSSKYLSPTTHHFGQFLNPNDRNDDYDYMSDHSENSNVSGYSQRRRLSSSASASTRSKDKRGPEVVDMDILEDVPAWLRSLRLHKYNNIFESMKWQDIVKMNDDELTAKGVAALGARRKMLKVFETIRQHCEENVSIKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKD5</accession>
    <name>A0A8H7UKD5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sorting nexin-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Autophagy-related protein 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_000885</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKD5"/>
    <dbReference type="OrthoDB" id="205639at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949:SF2">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="114"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2184972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="507" mass="58518" checksum="27A86FA7FCF11153" modified="2022-01-19" version="1">MEETDEYDSVQWDIHDATTTTDHNNPLSNNQQADTATIDPLSDIADSMTTAMNLNSTFESQDNSATSTSNLNNSFSTTSYNLDRPMYNPYIESQLAPTSLHNNASTGSSRSPSIVKDRKIRVSDPEKESDGHQSTYMSYLITSDIASVRRRFQDFVWLYNVLTANYPACFVPSLPEKHRMEYVRGDRFAEEFVEKRRASLQTFIERIGRHPILSKAQYFEMFLSSPQFNDTSARALREQQETMLDSISDSVLNAFSKIKKPDERFVHMKEQLDKLEENLTLLEKTLNRTNKRQDDLHLDYKEFSASMQGLAHLESGITVPILRFAETIGEYSKLLKTHSDTAEVDWASEIHEYLAYCTAVKIVLKLRDQKQVDFEELTEYLAVTEKERERTMYPTMMDRGLNITGYLTDKLQEVRGVDSEKMRREKILKLDMRIRELQEATQQSKEVSTSFSDQVEKEFQYFEQSRTVEIKDALASYTDAKCNFFSKSAADWKDVINTLEAIEVEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7ULX2</accession>
    <name>A0A8H7ULX2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_000507</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7ULX2"/>
    <dbReference type="OrthoDB" id="3362851at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="365"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="651"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2184598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="819" mass="93608" checksum="C8BF1AB1CCD93D35" modified="2022-01-19" version="1">MESDRDSASNSQRADSVSGESSGIKQPLSKRTRATSNAEPAEESPSGSSTASKRIRMTMACERCRLNDTVESLQERVRSIESNLTDIRSNTQIVVDEIRIKHEQDDERIANTPDDTQAVTSREAINTNNTHPQTHLNEHTMMRLPALNSNWKLSLTHSGLRIDTDILSMNDLYNILFSGVKRQTPPPEMALEATSPESSSSGSNSLLENTIVTKLQPLWKSKAKTFPLYSMWEPATMSEPKLADTTESFPPAMLDQLFDIHRECFLCLPMANFEEFKVKYLANEADPLLLNAIFAWTARHAAIYHGLFPGRDPNSVGERFFENARVILKDRFLKTSEETMQGLLTMYTYCIGKTGPRKSEYESEAYLYLGMAIRMCLDMRMHIEDPKQNRIQAEKRRRFFWLCFFLETLCSAHSDKPFSFPEEQTHVVESMECLPHETDETYFRVKFTKYRYKITQLYREIAVALDKKNPYFVTVTKLDKKLSEFFDQLPDYFQYRMGDIDKRQWKSKSFREQGCIKLNIEMNFQLCQLYSAFIESPGEQSSAIGLIAEQNCVRAANTIVELLECWSMLEQRWCHFTLENLMMATSIYSVVILKNTNAEIVNDAKKHLEKMALILSKSPVRQQKHIVNLLQQIHKTLQANSAIAIEAASSFDSPSVHDSPSNAEQTSDTPNANDRPQTVVNYPISSSSIERLEVGDYNVMPISASNIPYSQAPISSTSQLPLNLASRGAGGIQGSNPAFDLPTHLNATDLFQFTDFVYTPTLMDYDSMDEFRHQNQRMRAQPRRPSYPEYVDNRMGSYDLTTPDQYMGHSFVYYHNNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UNX5</accession>
    <name>A0A8H7UNX5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mago nashi protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_002144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UNX5"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1560.10:FF:000001">
        <property type="entry name" value="Protein mago nashi homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2185709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="17544" checksum="AF12145D8FF6C42B" modified="2022-01-19" version="1">MGADDEFYVRYYSGHTGRYGHEFLEFEFRGDGLCRYANNSQYRNDSLIRKEMHLSPTMLKELKRIIEESEIMKEDDNQWPRKNVVGRQELEIRLGNEHISFETAKLQSLSEVQESNDPEGLRAFYYLVQDLKCLIFSLISLHFKIKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCQ3</accession>
    <name>A0A8H7PCQ3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Unsaturated glucuronyl hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_002887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 88 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCQ3"/>
    <dbReference type="OrthoDB" id="2317065at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052757">
        <property type="term" value="F:chondroitin hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052369">
        <property type="entry name" value="UG_Glycosaminoglycan_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845:SF1">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2171265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="45995" checksum="82CD4AEDE72B1DDF" modified="2022-01-19" version="1">MQVQSSVAYPPKEPETQQDQPQDQKSIFKAVLDESNVAKILKVANQELTVPTTFPHSTNQGATEYIYEPATWWTTGFFPGSVWALVERASKRKMSTSFDDLVKVARKWEDAVESQKNNTNTHDIGFMIMPSFQRDLDVTGNKACQEVIITAAESLMTRWSDTVQCFRSWNSTRTKEYEYNDKDKYFLVIIDNMMNLDLLYSASLLSGDPKYAEHATKHAETTLKHHIRADDSTYHLIVYDATNGDVMASLTHQGYQHESTWSRGQAWALYGYAIVYKYTKDRKYLDAAKRLANYFMTRVEDGVVYWDFDAPRPCFWDTSAAMIACSGMLLICELENSLEYLPQVTSILKACVNGALTPENGATILDHSTVNNHEHANVRSADTGLVYADYYFLEVGNRLIDMGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDC6</accession>
    <name>A0A8H7PDC6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_008220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDC6"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056721">
        <property type="entry name" value="DUF7819"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323:SF0">
        <property type="entry name" value="CALCIUM HOMEOSTASIS ENDOPLASMIC RETICULUM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323">
        <property type="entry name" value="SR-RELATED CTD ASSOCIATED FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25127">
        <property type="entry name" value="DUF7819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CID" evidence="4">
        <location>
            <begin position="40"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="508"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2171840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="59669" checksum="FE734AB81F3C2DEC" modified="2022-01-19" version="1">MNSQPTQQPGADVAATDTNSTTIAYQKFAKLLMTTSDGASSIKDAEDIWTILHKIIIECSRAHVEAGKTWITHHCKQQSQFEGLTDLMIALVRNTDTFDDKLHIIYLVNDLLAHGSRKQERWMIDVLYPKLVPLLRLAYHCPKCDQQGRQKVLKVIGIWKERQYFGPPIITLIQNAMVMPMNASSRPEQSPHAKGSEFVESNNSQISTPMRMEQPKKSYFELPVGPMIDLAKLDDTPYKAIQTKDISVPSRPLPTEELKQAMNVYYDGLTFDDDTKFDAEGWENGFLDGYLGDVQTDKAKAEELQAHRKRVEESRLSQRARDKRSASPDDSYHTGTERTRGRSPQRTRSRSRSRSRSRRRSTSRPRYRRKRSISFGRSRSRSRSTSPPPGRRQPARSRTPPRSQVRSPPAQFGRGLGYSAGTEQRFRQSNQPQPFQQFQQQTGTWDTPRAGLGAGGVNSGGGGGATYFQAAQSTPRPQSSGDVFDNYRKNRSYTYNRDSGRRSEPLVCFKCNQPGHLARDCSALAAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDR3</accession>
    <name>A0A8H7PDR3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF423-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_001524</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDR3"/>
    <dbReference type="OrthoDB" id="269173at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2172047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="12543" checksum="865D4BA676BDFFCD" modified="2022-01-19" version="1">MTSTFYWKAGATLGLTGVGLGAFGAHGLAKHVDNDAKKIKNWEMAAHYQILHGLALLVVSSVPRVIHPYAAPLMLGGSIAFSGTIYALTLNREKFRFMGPVTPLGGVAMIAGWTALLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PE88</accession>
    <name>A0A8H7PE88_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Purine-cytosine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_004830</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PE88"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="467"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2172288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="53941" checksum="D0F351A23526AC05" modified="2022-01-19" version="1">MEVEKHFEYKEEDITTSGSSEEEQTHRLEENALHMETQGIHPVPEDQRTHTRMFDNFTMWFSVNTTLANLSIGALAIPVYGLGFWDSFACILVFNAIAVAPGAFFVTFGPRYGMRQMIITRFSFGKYGGIIAALANVLVCLGWSVINSILGAQLLTSVSNGRLPVWAAIILLSFITVIIAMLGYRIVHHYERFSWIPMWIIFFIILGVSCHHMELTPIESSGATEAGNFLSFAASVVGYNPGWVTCAADYSVNQPPTFKKRIVFVLAFLGSYIPSVLLQTLGVGVTSALATNAAWQAAYDGNGIGGLIGATLEPLGGFGKFLLVVLALGIVACNIPNGYSVSLSFQIISTSMVKIPQWCWTLVGCVIYTLIACFGADHFSDILENFLLILAYYAAPYTIIVLVEHIVFRNHGKSYNLEAWNDQRNLPIGVAAVGSLFIGFGVAMVGMNQLWFVGPVAKQIGAYGGDIGFELAIGASFISYLALRPIERRIFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEB4</accession>
    <name>A0A8H7PEB4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEB4"/>
    <dbReference type="OrthoDB" id="4199702at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034983139" evidence="2">
        <location>
            <begin position="25"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2172084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="304" mass="29839" checksum="6A735A17C9379033" modified="2022-01-19" version="1">MQNKTLLVLFSVFLISCFALTVSAFSFGSSDKKDVGAQEIVKRGGGEDKDDDDHKHGHDDDDHEDDGHGHGDDECDDAISRASASFAVGGKTYKIPCGTGAVDIEDICTEAVLGAGGIGSGEAVVVFGTGTGAITTAYPCGSGSSNVDLDALCAAGGPSGGAAIVTFGTGTGAITTSFPCGTGANNNADLGAICQQQTNTFTFVAGTATSTLTAACGSQGPINLNNFCDPYCAGLIGASVITQTVTATAACPSIVAAPTVGANVVVTVGTGTAATVQTVSCPTNGPQAVTIGTGTAASVTTVTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PED0</accession>
    <name>A0A8H7PED0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_008176</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PED0"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="148"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2171796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="503" mass="55891" checksum="6A7947C219D48219" modified="2022-01-19" version="1">MLSFNTNLFLNRSTLGFQIRPPQIMSFIETIVPRDIPRRRPSFASNLAHSVESWSSSYARSLHYMNDNLTRVSDDLSEDDVHHIVYGTSSSPSSSMTRTHPPNVNTAYTDEEGMPDEQSSLLKRKASIYSVQSRSSIWSSTTFDDQPKSTFAQSLINSVNILIGIALLSFPLALKNAGWILGAILLAFTCLLTNYTAKIIARCLDYPKATRELKTYADMAGAAYGMQGRIFISTVFMLELIAASVALIVLFADSLHILFPTVDTVTFKILAFIILTPTTYLAIRHLSYTSFVGILSSFTLVAVVCYDGATKTEHPGSLSDPMPTSLFPVHWMTLPLAFGQMAAGFAGHATFPSVYRDMAHPEDFNQVVNYTYLATSLIYAFMAASGYLMFGENVLVITENMMQTPGFNQVLNKLAVWLIVINPFTKYALTLSGVNFTIELSIFRHPSCANINKSKITMRLIQLISRLLVSSLVVLIAILFPAFDRVIVSVHRSNNFFDKNAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEZ4</accession>
    <name>A0A8H7PEZ4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEZ4"/>
    <dbReference type="OrthoDB" id="2289096at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="447" mass="49399" checksum="75AE806CB649BDD0" modified="2022-01-19" version="1">MFSSNVNLSLLDDNNLEIADKSSSSITSDAVKRATSTQALADFLSSTGPEEFLQKTAAKRGSKLFSRLLKKPSSHMKPPAAEGRKKYVEIVPNYPQPRDDWNSSGISTSSAATKCAMEISKALSSQNLKVPSYQPPPYQAIKEMTHVEPRKSLKENVSPVPPVPLKNARRSSKISLASSSAGEHQIMGSPSPSIQASALEERRNEARRKAGRRTSRSHEMDLVEAALSQRMEARRKSFASSNRSSSATTASDFMATEIANEHVKALQLTSVGHIDAVEANANRKRRTLTSSPPSITSVPAAALNRRRVRHAQVQTTDFPVNLNPGSAVSIETQTDGISEPSISISSSTDSDTTMVDRRKSSMLEDDDLTTELYHTIEMLQQQLAEEQRSKRRLIAAMRDSRDKNELLSALAYKKLRELWEEKCKWEGDCLELRGRLMEMEGNETCSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFQ6</accession>
    <name>A0A8H7PFQ6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_004490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFQ6"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="3">
        <location>
            <begin position="126"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2173117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="334" mass="37878" checksum="CC5B2167E63CA870" modified="2022-01-19" version="1">MVQTRFQSQFQGVKSFDLALDKHDTTPPPPPPPPPQPAPMLKSENFDDTLSCSEFASTTASFYSEGTPLREGSLEATIKVETLVEQLDDYECSTLDSLNARWPSIRARLKGMKPHLPKKTDDKPTLFMNLPHLVLDLDETLLHTYRDETAGHSEPDYIIYASENANHIITAGTLRPGVQKFLKWASEIFEVVVWTAGDDAYAATVMDILDADREYISHVLGRSACIQTRIGANGECMYVKDLCALGRDLSRTFMVDNAPHAATLNLSNLIPIESFYGQTTDHELEQLKQFLESKLTYRKDMRIILHRQFNLKRKLRQRINDWKHAGVSLRLEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFV4</accession>
    <name>A0A8H7PFV4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA replication regulator SLD2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_000244</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Has a role in the initiation of DNA replication. Required at S-phase checkpoint.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFV4"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22289">
        <property type="entry name" value="RecQL4_SLD2_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021110">
        <property type="entry name" value="DNA_rep_checkpnt_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040203">
        <property type="entry name" value="Sld2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28124">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28124:SF1">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11719">
        <property type="entry name" value="Drc1-Sld2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="87"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="490"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="503"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="538"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2172894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="555" mass="62655" checksum="5C97D0EB69A99B69" modified="2022-01-19" version="1">MIFFCDGSWPELKARSKARIGSLQFPQYHTQQEMTGLDKQCKVLKRKLKEWEAAFLKENGRKATVEDIAQNPELESEYKQYKVLKKKHLEESNLNKKQANTDKSSRHKHATPQDNNSASRNTQLPLTLSQNEEPGTPSTAKGLSFEFESPRIKRRSDSTPTRRRSFKVDAFVSSVEASTRRHTSVHKSGSQPPQSPLNRQHTVDESPSDKAKRLLRTPTKLSSALFTSPRPIKSLESVFQEGENNRKQPLLDLFVNTTKNPTTGESDSPIVRPPLSRGDESVDFFLEGMVDVKAQPDNSTEPVITQAVPRRREKQPGMEGFAPSNSLDDKAHMTDQETQQDYNLEKSPTRINISQPNLLSPLNFQIARPPLPTTKSSPGPGQSQFVKNIIMPGYYSSLAAGQDKRRLLMSPERRQRLLRQLSDGGIGNTLIDDADDTLEELANEQLITLKQSQDTPAQEEVYKKKPIQKRQTRLHKIPFVDMSEVRLNDKPNRLSAKRSVDDLQSESEDQVEGDEAMNESTSMEPTQRRSTRKKKGLNTGQCSLRCSSNPHSSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGU2</accession>
    <name>A0A8H7PGU2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NIPSNAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_005131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NipSnap family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGU2"/>
    <dbReference type="OrthoDB" id="10262843at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000004">
        <property type="entry name" value="NIPSNAP family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051557">
        <property type="entry name" value="NipSnap_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030476">
        <property type="entry name" value="Pentaxin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017">
        <property type="entry name" value="NIPSNAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017:SF17">
        <property type="entry name" value="PROTEIN NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00289">
        <property type="entry name" value="PTX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="2">
        <location>
            <begin position="80"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="NIPSNAP" evidence="2">
        <location>
            <begin position="191"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2173711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="290" mass="33633" checksum="502633C631C19413" modified="2022-01-19" version="1">MMLARSTSVFARATVSAVSRRAFTSSSLAPFAQAPLLKTHDSPSQKSGILESVLYGSKESKEEEKATHSKVLARGKYVHELQKHRVKPDRVDEYTALVAEHFPRIANDPVNNVHLCGSWSTEIGQQDTFVHIWEYKGYPGHKETMERLQQDPSYQRFVRDLRPLLISRENSMMLEFSFWATSPPRVTNGIYELRRYELRPGNLLEWEMHWRKGLDCRRQFCEPVGAWFSQLGQLNVVHHMWTYPDLQTRKKTREDAWQVDGWAETVVNTVKVIDKMQSSILKPLDFSPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PH38</accession>
    <name>A0A8H7PH38_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_005150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PH38"/>
    <dbReference type="OrthoDB" id="2796951at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034303618" description="Beta-glucuronidase C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="411"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2173730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="512" mass="55355" checksum="9787A69B881D1C85" modified="2022-01-19" version="1">MKHLSSALGLVALSYLSFVAAQNVTISLPSAIPANATVLDPRLCSMSLEFQSLEYYAGELGHPNQFTHNVVKNIVDRVGQPPAMRVGGNTQDRTYYDPSVLAVRLPAGNASVPNPTQMQIYVGPDFFKLAKNLPADTMVTFGVNLKFNNLTDAVDEAKAIFAAFPKGKAGRVVLERIEIGNEPDFYFDGVDSYADRWTEFAQNISQAVNLVPGQGPYFQAGDFAGHSANNFSITRLLQTDIVSGDTGARINTVAQHNYMGNGATGTISTLLDKSLVRGSLANFKSDIAYANSKGYTYILGETNSFYNGGATNASNTGATAIWATDYSLQAATLNITRTYYHNNIASGYQHYYPAVYNIWEPVGNVVIGNITTTKPQIQPQYHAFLVVAEAIGKTGKSRVAEISVGSSQVSAYGIWEKDELVRMVVINQQPWTYSSTGTRPVTTIQLQGLTSKKATVKTLYVPYADIAQGLTWGGQNFATDSGLPSGKVVTQNVKNGQINTLATSVNLITFHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PH88</accession>
    <name>A0A8H7PH88_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_005223</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PH88"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02336">
        <property type="entry name" value="ZZ_RSC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049898">
        <property type="entry name" value="MARR_BRCT_CHROMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041984">
        <property type="entry name" value="Rsc8/Ssr1/Ssr2_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032450">
        <property type="entry name" value="SMARCC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF41">
        <property type="entry name" value="BRAHMA ASSOCIATED PROTEIN 155 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16496">
        <property type="entry name" value="SWIRM-assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52032">
        <property type="entry name" value="MARR_BRCT_CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Chromo" evidence="13">
        <location>
            <begin position="2"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="SWIRM" evidence="11">
        <location>
            <begin position="415"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="12">
        <location>
            <begin position="644"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="649"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="861"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="815"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="864"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2173803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="893" mass="101418" checksum="9B4DE2B17C1920A2" modified="2022-01-19" version="1">MAPKANLKNGGTDLTFYEHEATVASFHSILSKLLQDLGNPDLNITPRQLSLFTGELQQFQEDALGLNATRAANAPFRIPAKLFKVDSNGKLTPSHPLYHILRAAYSYMLEQGWPDFTNFLSTAKRPKVIELITYITNILISKNIIRKPRIAFAPSVNDQNRKALSKLARTTNASITQDSNNATHILHGPMEDIDSIEEEWFRTLEKRGGRVLIHWWYYPDSYDTWMPETEQFMAEPEEPPVHEGAWNITSRWLQESVKYNEWMNEEDYEEIPSDSPEAMEDIQEENNHRKVSRHQRMESDAVSETTTTVGDEQATEVEDVFLDEDKQPLVKVCDVERDRPQTGVKTRKNEFEPYSHGDLTNISCFTYEGLRNESKRRRVEEMDTDDPTDLNENTLAAYREAKAYQNAQPIPKELIVPAAAATWFDPAKVHDIEKLSLPHFFGHEEEADSSYAQEYTQIRDFMMKKYQEDPSEYLTVLACTKDLTGDLEDLMRVHSFLEMWGLINYQVDPRKRPFETSLENEHDAGIMPFQYPEIDDDEEDKKELTSLRELYGQMRKEIFDPKLAGMVKPRITTLIAEDADPDDPDSGQSVVCDSCKQDCTDARYQSLKIKNTQVCPDCFLEGRFSSTMSSGDFLRVEGGMEKPSPEEEWTTYEQLLLLEAVEKYDDDWLLISEYVGTRSKEQCVTQFLQSPIQDSILKSLTELTEEEKNNTKVPFENAENPVMTMISFLSGAVNPAVGAVAAQSSLRVLLESKNEKDEDDPEDSDDENISCFSRKTLEQATSAGLAAAIEQAHALAKHEDAEVHKLIQVVITTQLKKLDLKIQQYEELEQSLVNEQKELEKQRVMLISSINAMMARAPHLSNNSTSTAATASSAAAPATPQKVTTPPTTTNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIE0</accession>
    <name>A0A8H7PIE0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="14">TC-AMP synthase</shortName>
            <ecNumber evidence="3 14">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 14">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">INT43_004333</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Likely catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Required for normal translation, by ensuring translation fidelity at the level of codon recognition, appropriate translation initiation selection and maintenance of reading frame. Also involved in telomere replication. Binds to single-stranded telomeric (ssTG) DNA and positively regulates telomere length.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the SUA5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3 14"/>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIE0"/>
    <dbReference type="OrthoDB" id="412787at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000008">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF16">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="Sua5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="16">
        <location>
            <begin position="40"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2174310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="390" mass="42542" checksum="2AC7B77945EE90DE" modified="2022-01-19" version="1">MAMTTRIAPVSAQSITFQPSSPNEHPLRNPQSIFSVGSEEAAVMEAVNFLKKEEAIGMPTETVYGLAANALSEKGISRIYSVKNRPQDNPLIVHVSSLSMLEKIMPNNTIPPLYLPILEKMWPGALTIIVPKSDIIPSAITCGQPTVAVRFPSHPVARALIERCGFPIAAPSANSSGKPSPTLASHVFNDLNGRIPLILDGGQCDFGIESTVLDGLRSPPAILRPGGCTYEDIRELPGMEKLQVYRKHFVDKQLEMVPTTPGMKYRHYSPEAAVVLFEYPLENSRVTTLSQAVNQEIEKLSAAGQQGLKIGVLQTGDNFHCSDNGTVQIVQKQMGRATHPEEVAKAMFVAIRDLDTQGVDYIFIEGISEDREGMAVMNRLRKAATTIIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJA8</accession>
    <name>A0A8H7PJA8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_006069</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2175007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJA8"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF353">
        <property type="entry name" value="METHIONINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2175007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="52659" checksum="7A886D4EDA4C605D" modified="2022-01-19" version="1">MATLSNGHSDETTSLLREEQADDSNKHDITSDISPLAVGNQKLERQIDWKTASLINVSYMVGGGVFVSPALTLAMVGSGGMNIVIWLFASFITMTGVCTYAELGTMVRELLTCLSMILPPFLTFSGGEKEYLAFIYRRPKLLLAYLFSIYNIIAIAGGIASQSTVFGRYLNFALFGSSVPTPVLDRVWAGKFLRRRNTILHLINACSVKTSLKSIVMLTAVKVAVLLLIILTGLAVLCGVMDTDADYLDNLSFNGTTMSFKPYASAFYFSMHGYSGFNAIQYSLDEVKNPIQNLPKIAGSALGLTSVLYLLTIISYMLVLPNEVIKNSDLTVAGSFFTKVFGVGFASRGLPIFIGLSAVGCSASLIFSGSRLVLEASRDGLLPYGHTFGYVNPTFQAPVNALVLQYVIVLIYLLATPGGVYQFIIAFAAWPAYIFFACIGIGVFMLRRREPDLARPFKANSGKVFSKSVSCVIDDITETNFWGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJC4</accession>
    <name>A0A8H7PJC4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_004369</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJC4"/>
    <dbReference type="OrthoDB" id="5545577at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048281">
        <property type="entry name" value="COA6_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2174346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="98" mass="11754" checksum="A04105DD1345858C" modified="2022-01-19" version="1">MSKESETANKPPSRRERQHCWKIRDEYFSCLESCGILDPETMNDKAEIREKGKSCLNKKKEYEEACMASWVEYFNKRRVLEERQRKYLQLAKEQSGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJG8</accession>
    <name>A0A8H7PJG8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2175046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJG8"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2175046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="78" mass="8761" checksum="3DF1A410C1BD3991" modified="2022-01-19" version="1">MAWKIPVIQLVIAPMIISKKPAMAETIPESRLATEEQMPDKHENIEPIVIEDMLLSKPEQFSVLRKPAKTLAAAVVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJR5</accession>
    <name>A0A8H7PJR5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJR5"/>
    <dbReference type="OrthoDB" id="2124108at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041404">
        <property type="entry name" value="DUF5588"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31919">
        <property type="entry name" value="ZINC FINGERS AND HOMEOBOXES PROTEIN 1, ISOFORM 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31919:SF1">
        <property type="entry name" value="ZINC FINGERS AND HOMEOBOXES PROTEIN 1, ISOFORM 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2174990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="298" mass="34141" checksum="2A67C80F82079ACE" modified="2022-01-19" version="1">MAEDELFGAAFDDDIFEAEKVRNPIAPLQVQKASYTAKHEDHGWFHNEDSIAHLMTTRHGPNQIKLTIEHDYLYKRYARALNTSLEYIAAVEDDSIDCKVVNPREIIETAALSAMKLDDIETAMQCADKINSRELGSLQTRGVVYMHGGRYRDAISCFIQYNNMRALDYKPWRHMATTFLKSYNDKPSEDNKLRLHLADASIKRSLTILSAGAWPNVDFARARYQREYDDIKELEIRIRELGGSASVFFAAMPVTGESVPSCLQLFQWDDIVWIDAECRRVAGNKDIEDEHTKSVREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKM6</accession>
    <name>A0A8H7PKM6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_001265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKM6"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF151">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2175618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="44985" checksum="B93AF3FB09D17390" modified="2022-01-19" version="1">MSSRRHGRTARLRVINRSHLDDIDHGKVIHDEDFERFRIWLRERGYPKSKITLAEFKGMMATVDLKPGDTLVSVPRNIMITASDVAKRLGAGHQLDANQLLVLEICDLKRQGTKSSWWPYVKLLPRDFDTMPVTYPSDVLDSAVPHHMQGEIREQRAKIDADYQRTISYMKRAKTYAGVDLTNQEYQWAWLCGSEEKSITGSNIALAPMLDFLNHKCDAKPPLSLNVVTITKPILLISGLLCHIAAVNSAIALDDQMEKLLSRLRASGTLGALKIKLLQDTGDYTIRKDEISFRTLSALRLILAANSAQCTAWERVVMGSQDIISSDIEKQVGQLLTDMCRNTSKQSERALTYLEVDSDLKNSLNRYALLFLKILWKEYQDIAYTAQNELIHNSLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLB9</accession>
    <name>A0A8H7PLB9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_005390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLB9"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="221"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="10">
        <location>
            <begin position="221"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="10">
        <location>
            <begin position="270"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="270"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="9">
        <location>
            <begin position="273"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="321"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="10">
        <location>
            <begin position="326"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="482"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="568"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="764"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="183"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="374"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="586"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="789"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="406"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="635"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="789"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="842"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2176157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="856" mass="96160" checksum="0CBD4BC2E3E8CC74" modified="2022-01-19" version="1">MQHFNDPYQLSTGPYRLTNSQPYDDQEPLDLTVSDPLQYNPMFKFQNAAQTSISGPPLQMNQQAFNQNPLNNDPDGQQRMAGQPGFSYPQPGFRPVTIPMNQQTMASSPYMSQRHPQQHPHLSDKLNSDNNVNDQYNSFHTMSAAEDMVASLTQASQNVPSMYDNVDIHSLVNSPAMSVVDLPSTNLPPVHANQLDSPPNSNLTPSPSNDTDVKEKGFGDRTQWTSDEDNLLRLAVQLYGPNTEKWSKIAACVPGRTNKNCRKRWFHSLDPSLRKGPWTEEEDRLLREGVARYPKQWSKIADMIKGRTDDQCAKRWRESLDPNIDRSSWTEDDDKLLLEKYEKFGTQWQKIALFFPGRPGLHCRNRWRKLQRNAQAKAGAYMPEQRRGDGNVNKSSPATEHERMSPQRSLESNSSSPIVPTIGNATSSKALQPTSDPSVLAQFHDPTAEAMAGDLQAHHQEHNQTPRMDEVRREMLEEMNPYGCDVPGCYASFSASSGLFYHMKGAHANLEGISKPYRCAIPGCTKKYKNINGLQYHIRDAKGSSGHAPAIVREDGTLESPVTDSRPYKCQMPRCKKAYRTPNGLNYHVQHGHGQPEMFPNAGMGEADSTLTGKRRRGSGQKGVANQSQPHHHLQQQQQQQQHQHQHQHQQQQQQQQQQQQPPGSNLHLMMGSPQQALAQFPGQSMASMAGVNMNVMRSAAPPNMMSMSQAQSPQMSLQRMQLPGSASSSPAQQHATLNNANPRLLAGMMNVNEQGRYGDTRIFKCPQINCGQAFTSLSGLQLHQRQHGQIQQQHYQQPQMPYQYQTSPHQSPHQSPQLQQQNMMFSPHLGFASIPFPGPQPGTNLQDSPHMNHNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLJ2</accession>
    <name>A0A8H7PLJ2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_005457</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCTP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLJ2"/>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.10:FF:000002">
        <property type="entry name" value="Translationally-controlled tumor protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01002">
        <property type="entry name" value="TCTP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01003">
        <property type="entry name" value="TCTP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="3">
        <location>
            <begin position="37"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2176223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="209" mass="23401" checksum="B64125CA898A7C60" modified="2022-01-19" version="1">MGKSVVFIGCDRKPISKYAEAVANLTIHPSSFTPSKMLLYRDIISKDELFSDAYPLKLVDDIAYEVDCKMITVSEGDVDIGANPSAEDGGADDVDSSVQTVNNVVYSFRLTETSFDKKSYMTYIKGYMKAVKSKLAETNADRVPDFEKKAATLVKKIITNFKDYEFYTGESMDPDGMVALLNYREDGVTPFFTFFKDGLAEEKLVSIWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PM30</accession>
    <name>A0A8H7PM30_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_005479</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2019644at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2176245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1611" mass="179942" checksum="2AB283288634D37E" modified="2022-01-19" version="1">MADFHSVPQWSQGFGDLHSLIAETLRSPTPTAVRGLRQGIESYRPLFIQLLDEPPKSEDHRNTISSGRAIINHDRKKINDHFMKYTLFLSDQLNINEHVAASLIYAGKENMVKFDNTEVDSAITLYHLERGYLLESLVQLVMIARNGNVEPTLRETCYSFINDLMKEQTSVDNRNAAKLGTLPVKILLTIERLQKQIESVEKTGALENAQPTAASATQPGFGKLGQEITDYRLKRLRDERVDLARVLYHTAALLGLDADESIELVKSLQARGPKTDIGHYLLMCFFASTNMAHDTAMISNNHQESICQDTRFISQFDQILTGDGWGSAFLRASVALKWSLFLVNAVKSHAGLQDKLPFGEDRVLQLVKHAIEDDVFVYLGRDLLSFQCDKDRISEKAMAFKQSDGNAHLSRKHIEVCENFREPFIHEIEAMSVSFIHHMSTVLRELKLQEEDADIPMYQIGHAKTAIIPPEASQATRHDLENFVLLLSNVYRNRPEAGLKFWPPDDGGLHNFLKWVTEVRVVGTVRAVYELLASLATGEKCALQAFHFFSAEGTTPNPTAQSLFSWPKLFAAINFYTPLLNNYNKDSPATLPMEEERVLAAFLNVLRQVILYSDVARTFFWENESFAALASLISLLGCPTTPALRASLYNCIAACCTAKDDNDNSTAIRCSQQIWQVLEDSGVLTSKKQRQALELQQRQQQQVHTGLLGQPNQLFSIPGTQPTSTIRVSGSHQEGGMIYDIAQESKLGTYPETLAFINLLKSLIHEPPKGNGQLPDLVSISPSIPERLGAATRSPGLEPYVSLVIDEIFLPASGRKYNYPTEKWKVIEACLAFFEKCLLTFNLDTLNTSPKMGLSSDNILLAFVGHPGFEILKRLLSGSKFTVEIFKIVEYGIQTVHNNTMRTQFFAKSVERCLSIISHTLKVQNTFCNVLIHQFIKNSAGYSGADMIIAGFKYPTLPSVVTLDSFLLYHANVIVQIALFANCEESDQISLHSINIISALSASPNLSQLSTDLTSSSSGSTVSGLGVKLTQVLAASPDHLAIIHGFLEQLEVGEPESVGYGDSEYDSYNIPFWVNQNTSSNKMTQGTLSSSVRLAIVNLILDNLDAKRSKPTVAHFILGFDVFGSIAKTDIKDPVIAGPKVSCLHAILALLQSGIELSSDTFNGAMDEDDREISQLSASHPILAEKCYQIIYRLCASEATSQPTTRYLRTREDFFYSQFKALSSNFQGRPSGPLSPFNGTLVSTDGIHKEIDFFNLKALLHLRTWLLKSIAIELHLTTSAGQKSYASRLINLLYGTNGMSDDDADMMDYGNYQQPLAKMLEIFSSLDFTWTSPLTEKASGFKAKYYRGFYAEKFQHDNSQGCPLYDIRAAYKHLRSELDRQIQGGTITSVNESALVEEEIQRILEVLIAQNQSREIAFARYQCLRAWKQVVHLTLTECLDLLPSDTRERILLDLIDALLPKLTNESYSIITYDISELLLACMTRLRYDHCPQDNTNAIKLKSRLPDEKLRSLFEGILEFGNTDSTSVASRGNIYVTLISFLLYIQDSRKQNPSTDPDRLKAYMLSTINANGDNFIQQLYRDAQDGVDIWRTTANIALDALSAIVDIFPDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PN19</accession>
    <name>A0A8H7PN19_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Farnesyl pyrophosphate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_007758</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PN19"/>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000006">
        <property type="entry name" value="Farnesyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2177102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="41682" checksum="672E701B52BB1A95" modified="2022-01-19" version="1">MVDAKAIKEANRKAFLDVFPQLTNEVLDELRKYNMPEDAYEWTKQNLEYNVPGGKLNRGLSVVDTLYILKGDAATEEELHKARILGWLVEFLQAYFLVADDMMDGSITRRGQPCWYRKEGVSTIAINDSFILESCIFLFLKKYFKETSYYIDLVELFHEVSFQTQLGQLCDLITAPEDKVDLSKFSPEKTTTHLVIARHKFIVIYKTAYYSFYLPVVLALHMAGVHNAEAFKQCHDILIPLGEYFQVQDDYLDCYGDPAFIGKIGTDIQDNKCSWLINQALVVANSEQRKVLDENYGKKDAKAEAKIKQLYIDLDIESRYKAYEAKSYEELKALIAQVDESTGVKKQVFIEFMDKIYKRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNJ8</accession>
    <name>A0A8H7PNJ8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_005671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNJ8"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000041">
        <property type="entry name" value="HMG box family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="24"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="24"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2176431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="272" mass="31032" checksum="B316C610BDA75DAE" modified="2022-01-19" version="1">MKLEEYSKNTSPTPSSLAKADKRIPRPSNCFIAYRMAIREKVIAGNPKMNGKEISQLAGKMWRSEPEYVKDHFKAIAEKLKAEHTSKYPNYSYSPRKRKNSCVHDSYSSCEESYNVDSSLNKKSQRESNRHETLEENTPSKDANVVCDEMTTLTKGLKKADNHTLSYIVQDKQRDQFELLDAAGIALAHDLRETNVRQEHDTDDLIANELKYAEDYHLLSSSCDYGLSDEAPSPSPMIPDLVSSVDSDWLQYSPYAYTPGYDSLYSYYVFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPQ9</accession>
    <name>A0A8H7PPQ9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">INT43_007961</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2</text>
            <dbReference type="Rhea" id="RHEA:38959"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPQ9"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="UniPathway" id="UPA00661"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000005">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000013">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 14" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="17">
        <location>
            <begin position="36"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="16">
        <location>
            <begin position="152"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="18">
        <location>
            <begin position="293"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="15">
        <location>
            <begin position="505"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG2177304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="698" mass="78321" checksum="4021C1E15A9B7CC5" modified="2022-01-19" version="1">MATFNNNVPTKFPKLAPRGPAGDLVLAAERAKASFDPQDLTKFMYDEEWLQRLNRILNIIENEPAFDKSERYFLGRTDKVNQAYWKDKRTVELAKKHNWTEADVQMASFLWDQSSPFSLHSSMFLPTLKNQTNDEQKKLFLEPALKHQIIGCYAQTELGHGSNVQGLETTATYIPESNEFEIHSPTLTSSKWWIGGLGKTATHAIVMARLILNGKDHGPHPFCVQIRSLEDHRPLKGITVGDIGPKFGFNTTDNGFIMFEHFRIPHISFLAGYAQVKPGSGEYVRPPNAKLSYGTMVYVRANIVMGVRFALAKAATIAIRYSAVRNQFVDATNPRKWENKVVETAVLDYTMQRYRLLPIIAQAYACFFTGREMLRLYNENQKNMSSGNFSLLADLHASSSGLKSLCTTMAVQGIEDCRRACGGHGYSMFSGLGLFYQDYLPNVTWEGDNYVLTQQTARYLAKQFRGVAANKTSENELNFTSAYMYDFLQNPSSQCPATQASDFLNPEILLGAFRFRAASMTQKLVHALDNQGKSWNSMTVEIARLSKAHAQLILLSNFVSGIQNARNELASTSLAALKTMAMLFATHTIEQELADFLVSGYLTPEQASYVKEITLELLEKVRPDAVSLVDAFGLPDYYLHSALGRYDGKVYESMTEMAENEPLNHKLVTDSYEECIKPLIHAGKAEGRWNGEGMSAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQ62</accession>
    <name>A0A8H7PQ62_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_003299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQ62"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF27">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2178046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="94" mass="10879" checksum="73CED77A41182145" modified="2022-01-19" version="1" fragment="single">DMSQYRSLHLLNTQGLYLNLEEILYLLPDEWPLQVIEGFLTQAFRKATENRLQGKIALGLSRGENLMVSFYYYKYNMVPGLLIMIISLGCPSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQA3</accession>
    <name>A0A8H7PQA3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQA3"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00302">
        <property type="entry name" value="cytochrome_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2177943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="61755" checksum="0890C68DD8993E0D" modified="2022-01-19" version="1">MMAQEYHIVTSLLQMVPRTLADAFLLRKVGIATGLTILIGHCWFTMWLVRRYLGPMRTAPIAHTSNFWISKLGTAPPPNDKETKDELSAFLIQCGQDPSQLPWCVCWSFLGTPLVILNSLQSIKDVLIDAQLKKSRNGKPAAQRGRLINKIQNIVFGGKNINNTVGEEWRWRRLVMGRPFSKQKLTTNHLPFAIKRVKELTSTIQQAADTRQTLELDDVFMDLTMDVINQYLYGRSAEHELDYSIVGGKTNLKHEHHLLGLGFMSPLIWLPFGIGQSAWAQQAFAPARYRIKRFINDSIDRALEDAKACNDTKFHSLAAEVASKYNDDRVDLLNDFLTITFAGHDTTAHTLAFAFSEIARNPQIQEKIYEETCAVFGPVMDDSTITSEKLSQLSYIRAVYQETMRLYPAVVFIPVHANDNIMADGQIISAGSEMWCNVRGLQMNSEIFPEPEKFKPERWLEIEVGSQNTRLHNFPNLSFTLGPHSCLGKSLALLELRLAIAHIVHHFTCSLKADHIIDTKVELTTKPRYGVPVNFQRRCYHMIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQI1</accession>
    <name>A0A8H7PQI1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7082 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQI1"/>
    <dbReference type="OrthoDB" id="1751210at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055509">
        <property type="entry name" value="DUF7082"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463:SF1">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23305">
        <property type="entry name" value="DUF7082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7082" evidence="2">
        <location>
            <begin position="338"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="506" mass="57095" checksum="B97AC915302F817E" modified="2022-01-19" version="1">METTLSPGMEEKQTYYRAIETVVLTPNSLFMSITAPTLTLGSNFELRPKQTSSEYQKLTHGLIPTSISPLDGSSMASNESSKDQPPRVLECTPNEGPAGITVRVVIQTLPSNPILKLAFGGLVVDTKQLDNANFTTLAAIVPNTTHTQNNSSQVPISVCIYDNDTVHNSWVIGEFTYTEAQDKNDRKRSFGADPFMANKRMHEEESMFPHPDQYPNFYSMENGMMPQNPYAFAQLQQQQQQQQMRPQDPKMYASQPKGMMEGYYRSQAPSMPYTGYPNSSMQNMMSPSGIGLTNMLGGDVSGMQGQRPPPGYLPQSSPPQQQQQQQPPNYATYSGLLNKANLKIIGDLDTMAQAWTAEEWNARRRLVQFWRRQDGNEIHCDFQAVQQADRQPNSIVVSCIFWQERNDCFITSVDCIYLLESLIGVRFTVEEKNRIRRNLEGFRPLTVSKCKPDSADFFKLIMSFPNPKPRNIEKDVKVFPWKTLPYALKKIIGKYTASYSSTAGIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQR7</accession>
    <name>A0A8H7PQR7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein Abitram</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Actin-binding transcription modulator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003303</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABITRAM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQR7"/>
    <dbReference type="OrthoDB" id="48130at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039169">
        <property type="entry name" value="Abitram"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13651">
        <property type="entry name" value="PROTEIN ABITRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13651:SF0">
        <property type="entry name" value="PROTEIN ABITRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2178050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="176" mass="19932" checksum="DC2D9C13BB3A003B" modified="2022-01-19" version="1">MEATIDKEVLSKTADVEDLYDLDSWAQKTAHWGENPTAFLERYFTIHYHVDTHVYIRQPPNKLCILGLSAEHAVVKSSNAISCKFFHESKTKGQKVKPDTIIAEITVGDQVYPIRATVFGEILEVNPRVSEDANLIRTHALDEGYLVIIRPRSEDTAVQLKGLVDHDTYHITKNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQT9</accession>
    <name>A0A8H7PQT9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQT9"/>
    <dbReference type="OrthoDB" id="42919at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044662">
        <property type="entry name" value="HS1/DABB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178:SF10">
        <property type="entry name" value="STRESS-RESPONSE A_B BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="2">
        <location>
            <begin position="3"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="97" mass="11028" checksum="1DEFD8F961811B9A" modified="2022-01-19" version="1">MTVVHVVLVKFKAEVGEAMKQELCNKVVSLKDVIPGIIKASAGKNFSDRSKGFEWGWVFEHTSKKDLDDYAVHPAHQEFVKLLGNYRTDILAFDYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQY8</accession>
    <name>A0A8H7PQY8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQY8"/>
    <dbReference type="OrthoDB" id="17687at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000015">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="524"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1075"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1086"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1100"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1126"/>
            <end position="1144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2178155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1164" mass="132727" checksum="B21970081DDE5415" modified="2022-01-19" version="1">MANNPLADPPRNVFTIPTPTDMSLNPFWTTTKQSDNFILQKASSSGNPLFKNVLRTIANVFDTSQPPYRILFQREVNTSCLLIATADTESIIENAWNWIVEKMIPQLEHIDDPYDKEEWVASKIQYIVTSIDEGADDASNDEKVRNASRSFRQSFDVPPSERLVNYYSCAYNGRQGWLYISENYMGFYSFLLGVETKLLVELKNIQDMKKEKSKRNMFSDSLLIVTKDKKEHHFSNLFRRDETYDLLVQLTSLAMEKLLKNTGARAPGAPVIPLLAGGSAGSSPLASSSTTSLPSSNLTAPLKKTMEAQKRNEMFTKRFRIPLTEVLHETVSVRCIRVLEKDEQREEITFRGRLFLSGGYVAFEATARQPAPQQNSSACWFALPLFTIRKVERLNSGSYAYSLSLTTWHKMEIIFELEAEKVECENFCEILKNNLKDQVQNMKQLKPFLASCWSEFLLKTSSAWPTDEQGPLRGGLGLQFGFPGDVRELQDRDKMSLWKQYFEVNGRNLTTIHLPTFGKLLRIGLPNTLRGEIWEMCSGSANLRFHHKGEYESILKEYEGSTSLSTDEIEKDLNRSLPEYAAYQSPEGINKLRRVLTAYSWKNPELGYCQAMNIVCSALLIYMSEEQAFWTLSVLVDNFCPGYYSTSMYGAMLDQIIFEHLVEKTMPILDSHIKKTDVQLSIACLPWFLSLFINSMPLLYAFRVLDCFFMEAILKINGDELLKTTDDSAFFDILKAYFTTLDQPVRRTPKTKAEKRITNFNVLMRVAYREFSLVTDEMVAELRRTHQLKVVAGVESFTKRTGIRNLKDTAHFSKDEVAIIYDKFYGALYYTEKTGKRNDAKMDEVTFRRFLASMAHWIDKGFRSDKLTSVEVSAKEHLFLRRLYEHFDRDKDGISLQDAVLGLSDIFHGGIMSIIDLFFTLYDTDNDGIIRSFDLLEMSKELLSIFQTMQILDSEHLESVTALLLNAYEQSDIVSGKDVSDDKRSERKAKYTLPEDIPIETLMMHLDTMFIGDDDLELSLPSFRMVILTNETLELFFDRSFPESFTLTEAVGDSQKSLGREIFDHLFVSGQTLASRKPASPGLKAQSPSLSPSVSQRTNSPSSAPSGSPVVDNDLIDFFDSTNLESTEKKSKADDSADSKKPLPLDDFFRQLDHFESDDGYQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PR80</accession>
    <name>A0A8H7PR80_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="1">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_001673</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PR80"/>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16482">
        <property type="entry name" value="RING-H2_UBR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="E3 ubiquitin-protein ligase UBR1-like winged-helix" evidence="4">
        <location>
            <begin position="515"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="922"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="784"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="922"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2178827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1061" mass="121704" checksum="9BD007BE6BF126ED" modified="2022-01-19" version="1" fragment="single">MQEFQELDDQETQFSEQIGVHSMAKKKQSGELVLGSKMLTEFKKKLRLDYFMLLDLRLWKDMRMCLRKLFISTLIANLSYKRVLGLRFARNYPSVADAFLLRDREFPLSVMLFSVQLLTVPTIATSLVSDYNFFGIMCSVLSSFLLTEQITLPLGDQIRELRLNCERRSFGTRKYYNNFHDLRYIINSDAVRQRIRSEPLLLRQYLDFITIFQGMNPIVRQAGSHVEYESASWVDAFNATLQVAKSGRRFTDAFLVPNDKEDADELAPLQLIRAVMRVIKHLSDWIPPKNEVRDESTPFLQYSQLRVAGVREQEFHTVKTANCGNFSIVKFDVTKQPVSLHHPVHWLLSQLLENVNLLDEKALEHAGWSGGIKAMMSKLQDAESKFTPDDTFLTILDWPIRTMVLLCQIRSGFWVRNGYSVLNQAHHYRDVSLRENTFDTDLYLLQFGFILLDADRLFTSLLDRFSLLPWFSGKPSQSPYDSAQTIYMVEEMLSLLIVFASERSHAANLSLEEKTRREIIQNLSIAPMAHSELAKKITESMSENAKFDQILSEVAKFKAPDGLIDHGTYELKPEYYSDIDPHFWHYTRNNREDVEAELQKIWKKEQEAKGLPAVADDFFIVPKLRRIESGPFVRMGNMLHSRILLQIIFYGLWNVKSSNTVVSDTIVEQVLYLAMMALVDENNDYVSPSSNPDGWDREEYGMPGFVWYASTDGFAVMANELEREHITLLRLLLRIIEDSRLSHLHKRCLWIVNHIEEQGSKEVKHLISAWKEERSIFTANQSGSAEANNNLTEVERKKQAAKDRQAKIMAQFAQAQSNFMSQNEDMYDDDTDSDIDDEDIEVEESSGNGGVAMTEDGELEVQRKFHFPSGTCIVCQEEADSSELYGMLAFIQPSTLLRQTPLDDTTILSDIFSIDKGLDAEVSSEVPSSPSDKSTAGKKYTRPSAIHGFPPQSHKSGLHMSTCSHLMHVKCFETFYLSIEARHAAQSRYKHPENIVRREYLCPLCKALGNTLLPVVWKGKTESYPGVLAGANDEQYKSFMESGIDQLLTQLEKHRHFEPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PU85</accession>
    <name>A0A8H7PU85_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PU85"/>
    <dbReference type="OrthoDB" id="10268014at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="548" mass="61385" checksum="314C3B95CC550B0E" modified="2022-01-19" version="1">MTHSIQTDFTDNGSKLKDALTQTTPTTTLSGLTLSDIHKVVANTQPSPPKSPDSEEAKRSSKKGAEDAKTVVQGDFESSEHFYPRVLNAQIHPLVQSFFTLGNERIIARYTHLNPQVKPETLKEILSYTPKYFQWAGSDLFNVTTSSGQRQMIVIETNSCPSGQKSMPLLSEIDEHNEHGGYRTVLESAFHEQLSKADKSLGDLAVICDKNMMEASGYAAVLAEVAKEKVWLAEWHDGEEDVPVKWVDRVLHVRDANKEWHPIRACFRYVTQKPWNRFPLNTKTIVMNQIISCLAGGRNKMMAARAYDFYNAELVDTGLSVRVPETINNVTRGEIPLWIHSMGGHAVLKVPYSNAGQGVYTITNPNELKEFLEQDHHYDKFIVQSLVGNASWSSVTRSGKFYHVGTIPNKKSNTFVSDLRMMVTGNADGFRPICIYGRKSRLPLTTDLDPNANTWDMLGTNLSVKLPDGGWTTDTGRLILMDRKDFNQLGLGIDDLIDAYIQTVLAVIAIDRMAVRLMASGTFDYNLFSSLNPDNALMQEIKMANEDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUL1</accession>
    <name>A0A8H7PUL1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_008433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUL1"/>
    <dbReference type="OrthoDB" id="185493at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2180854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22926" checksum="1B4CF6580E79591D" modified="2022-01-19" version="1">MNINTDGTAATILKDEIIHKRYITVWNRTTRFEDGREISWDVVGHSTPLPTFVTVFTFDTNTKTTCILKEYAQGTNEIKYCCTAGSFDRRKHTDPLEAAQHELSEEAHLKGGSWVSLLPTAQPNGISELKWGTNRFVPYICINPVLDENPKDRDAEEYMEIVRDVTIEQFTQFVMSGEVMLPSVQTGWMAIEWLKENKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUT3</accession>
    <name>A0A8H7PUT3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUT3"/>
    <dbReference type="OrthoDB" id="2148946at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="42762" checksum="D1C96C7539942F5E" modified="2022-01-19" version="1">MNRLKQAFSPKSDQEKSKKRFSLFHKDNSDKRFSVPNASKSPSLTISTSELDRHSGQPRSAVVSGTNMEPTAAKSQKRHSMFQSAKDISPIQQHATATLLAETKTTLISPVMAADTSDVKRSSSLRRGRSLIVPPRRKSTRVSTSLSSGNEKGVSTIMEESDPSEPPRPPAPQADDGSSTPQADEYLQLGVQFHESGKLEKATNYWRMAADMDHPLGLFFYGIALRHGWGCKPNPAMAVRYLQRAAECAVYDLQTGIAQSSLVAKQELVLAIYELGICFRHGWGVPKNIATAAYYFEIAGNLGDPDAQNDLGFCYAHGQGVKKDNFKAAKYYRMADRQGNGIVGNSWIWKPKYDIVDEPNWDKSQSPSNTMAAVKSIASGKHEPLAKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVJ1</accession>
    <name>A0A8H7PVJ1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetraspanin Tsp2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_008962</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVJ1"/>
    <dbReference type="OrthoDB" id="2156690at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF556">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2181379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="35944" checksum="DD0663AEAECCBC65" modified="2022-01-19" version="1" fragment="single">MAQLHHSIQSMALSNNLSPWNSTEHLPEPPVLPWVHNSESRQRQSLDASSLHVMKRYNPSDDQVKKKARWTVHKWWMLVSNTLLFIYGLGGVMLGILTYFKLYLRADVIIVSEPLLLRLVTAAGSICLFTSFVGYSGIMLNNRAILTLYNFLLWPCFALIAAIGYVSYRKQKWNLEGKLSFQWHYSLTASDRSRVQANLHCCGYKSFTDFHERSNKCFPRTLLPGCKFKYQTFSRQCLTNCYIVAFALVPPHLFVLITALLCSNHINRKFGKGLPPKIYRLDYQGLVAGTPTGSSVNVSRLDRRNVPQNGNGYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PW07</accession>
    <name>A0A8H7PW07_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PW07"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="204"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2180226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="472" mass="53344" checksum="CDE956CFB8392E59" modified="2022-01-19" version="1">MPETDLAAPWVATSSNVKVYGDIKSSHQRQSSNTSIDLYSRPIHRQPSEKLQQQRYRCMNSLPSDSKLNAPTNTIRGNKPKPRIHIKQVNKVPERGMGIACPSPVSPQFRVNFLQNDPSQSIVDTHLSLDGATQMKALLDTGKDGRSVLGRNFPKSIDPNYIYPLPSDDAELSRLDKEHELVKELFNCIYRSPIEKLLDKGIKVLDVGCGSGSWCIEMASKYKRSHFTGIDICLKRDGPAAPNLTMLKVDMSEPFPFARETFDFVFCRNLSLAIPFDDWDRTIEELTRVAKYNAYLEFIEADWELKRTNIAMKKWNTFAIAALRNRQYNPRIGRNLDVFLRFHLSEVNNTYLSMPVGEWSGTKIGIKAQSYWTDTIASLKPIILGSTDPKVIGFASYERLAKLALKELASSQTYCNYYAYYGRKAEEIPIYLEKRQSSRRNRSLTSNKTLSGSSTSSPPSDCSDTTDTSGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PW91</accession>
    <name>A0A8H7PW91_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histone-lysine N-methyltransferase, H3 lysine-4 specific</fullName>
            <ecNumber evidence="2">2.1.1.354</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">SET domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">INT43_008480</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PW91"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19169">
        <property type="entry name" value="SET_SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000010">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024657">
        <property type="entry name" value="COMPASS_Set1_N-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037841">
        <property type="entry name" value="SET_SETD1A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11764">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01291">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="17">
        <location>
            <begin position="108"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="18">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG2180900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="245" mass="27949" checksum="604D198B444579E3" modified="2022-01-19" version="1" fragment="single">IENMQNITKRLLQSIDASEDMNQEPPAHKSGSARTEGYYPITEAAKSRYLPRNRRVFDNNSQLAASKVTSRMNRVNNRKLLVGMDMHKKATATDSDILKFNQLKSRKKQLRFAKSPIHDWGLFAQERIDANDMVIEYVGEVIRQKVADHREKAYERCGIGSSYLFRVDDDTVIDATKKGSVARFINHCCSPNCSAKIITVDKQKKIVIYANRDIELGEEITYDYKFPIEADKIPCLCGSKYCKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXB1</accession>
    <name>A0A8H7PXB1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_007009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXB1"/>
    <dbReference type="OrthoDB" id="2238774at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2182082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="159" mass="18087" checksum="D6CAEC1C6844F1C7" modified="2022-01-19" version="1">MNASDDHKTTAEQAAESPIQSKANRLDKRLLVISGKFRRRSNPSSGYHSLDELWTDLYPCMDLALSFEPSWSMQYMLRITGEFHEYCVGFGKEHDVQGIPPMFRELEKAWLRLLEVQGLSTTDKIRSLNIFRDGNDKAGWLGIGEVYQQAMQAAVPAMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXL3</accession>
    <name>A0A8H7PXL3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_007074</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXL3"/>
    <dbReference type="OrthoDB" id="1929172at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034586535" description="GOLD domain-containing protein" evidence="10">
        <location>
            <begin position="28"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="39"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2182147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="217" mass="24236" checksum="49AC40385F123E29" modified="2022-01-19" version="1">MSSSRVIATTIALFALIAVFFTSSAEATALTYNVAAHEKACFYSWADVPGKKVAFYFAVQTGGSFDIDYVVEGPTGKVILSGERERQGDYVFTANDVGEYSFCFSNDMSTFAEKLVDFEITVEHEARPSYQRENPAQPPESLSFMEESLFRLSGSLSNIARTQKYFRTRENRNFSTVVSTEKRIFWFACIEGIAIIAMAGLQVFVVRNFFNVKKGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXZ9</accession>
    <name>A0A8H7PXZ9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BRO1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_007272</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palA/RIM20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXZ9"/>
    <dbReference type="OrthoDB" id="64867at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="4">
        <location>
            <begin position="15"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="788"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="665"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2182342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="823" mass="92892" checksum="E6F96A3CBA1BEB8D" modified="2022-01-19" version="1" fragment="single">TSYRYSFSMANASTNLLAVEVKKTEKVSLTQVLRDYISNAYAEHPDLYTDDFRVLDELRMDCIHLGSQHNALNRLIKYYGQLVFIGSKFPIDVWYLNLCIVCHSQPANSACTMHLACVLYSIAAMQSQLGIAENRATEEGVRRACMYFQNAAGAFKHLQDVVIPDIRTAPTKDMTTSALNTLVSLMLAQAQECVWQKAAIDHLRDGTIARLAVQVAEYYDSAYELATNSSISGLYPASWLSHMQIKTWHFKAAAQFRKATECISQNKYGEEIARLQLADTYVKKGLDLSGSFLSRGSSVGEMVINDLKSLQQIIQSNLARAQRDNDVIYLEPVPSSSALPEIAKSGMVKPVNTPEITDPVDLMMENERSHGKMPHALLGLPLFQKLVPFAVHQAASVYFDRKERVLKTDIMGKLEELNAVYHSTLRSLNLPTSLQALEQPIGPPPSLLKRAEEVKSKGGTSVLYDMTEKVRQLSLKNSELLDQALNAIDEELEEDDSLRKKYRERWPLPKSSELTGQITAQGKKHRETILSAQKADQIVHQKLDLWAKIIDILSLPQQDIERSIPSVHVPRGYSAVEEDDDLARQNNAARELRVLLEEAETHVRVRKDIIERAQRTSMADDISPALLNKAAQLTANSPIAKIEPAQFEDLFAVQLRQYDEYLKAVDQQEEEQHILMRKITDANEKFLEARKYNSAIAKREKALQNLEQAYDKFQEIYTNLQEGMKVSHSICTEPLFTFKYAHNQLQFYSDHGQSLTNFKKKCIEYQQYRRNEAVQALKAMGETPLSLSSLKLNAPEEPQSPGSGRPGWNPSFGIRFSGKQNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYK5</accession>
    <name>A0A8H7PYK5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYK5"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044617">
        <property type="entry name" value="TCHQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45374">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE TCHQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45374:SF1">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE TCHQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="107"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2182486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="28115" checksum="ABE09B10519CFF1D" modified="2022-01-19" version="1">MVRLVIAEKGITDIEYKLVDLDHKQNLSPEYITINPKGQVPAFVVDGQSITESLDISMWLESHYSSPSLLPGETSARSRVMADLAELYEINFFAMLFGIPTQDRVAIERESKESIFRENIEEAERHMKEHPELREQYEKRLETYRAKTGRLVEPAYVQENWKKLGKLLDKFEESLHKGKFLSQENDYCLLDAHATAVLARLIKVDKENEIKTRPKLSEYWSRVQERDSFKKVYDRPTTMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZ49</accession>
    <name>A0A8H7PZ49_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_006395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZ49"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2183389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="317" mass="34168" checksum="7067C6AFACFF477D" modified="2022-01-19" version="1">MPTITPLISKALTSTAYDVKWIPQSARLCTIGASNRGAGVVSVYKMEGKQLVLVNETESGSTFRCGTFGAASGHERHLATGNFDGKLQLWDPERLELPITSTKGHDSIINAIDGYGPLNCGSQSSALLTGGRDGRIKLWDVRAELSPMTVVSPENQSADIWSVSFDSKISGRLFATGYDNGDIKIFDHRSSGYIWGVNVGSGVCSLDFKSTESEKLLIAGTLSGYHIINLDTGAISDAKLNTTIWKVMSVPAQPNFYMTASGEGHLSLYKHGSLSTPVTKSKQTEHPIVSFDWNTSKQGLFAAVSFDQQVRIGLVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZD5</accession>
    <name>A0A8H7PZD5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZD5"/>
    <dbReference type="OrthoDB" id="2389504at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2182224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="433" mass="49140" checksum="46CA8349082B3765" modified="2022-01-19" version="1">MAPNSQEECRDSQVEHSSYLSQGSSSSKRKTHWRAGTETAHTGVSQDNLETPPQEPKVTYDNKENHPVSVFEHQDTAFERKEDMKTYTDQELEVISHDSKMDPIDTSGSWSIGEFTQEETKDFANDQSFRDHRLFSQIADTQIDIDDGSSEYSSVLGDLSPRLNQDESNSGFKDENEIENLGLDPQLEVSLERDETVIHRRQSKKSITDYSLVAPSKAIHKPPTFLIPTTNEISLGDSDEYGKPESSKRKQRQSTYGSDGDHIKLEQNGLAMKAKKVIDAENQAHSQWDTEVRGYMAQLGSIAYLGPVYPNTELFRILELFDDNGLINTKCVRIAEPPEELVWTQVSAAGHQSQNESQANWSPNDVDSNNQNEPQLIFFSFANSSLSLDMQRRFYQSQVVRIWPPWHEHLLQLDDGSVTTVKLVNRFITDAIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZN9</accession>
    <name>A0A8H7PZN9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_006697</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZN9"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF7">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="136"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="197"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2183689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="308" mass="33169" checksum="10F4C7E6C0B76645" modified="2022-01-19" version="1">MNEKENALANHILSNIQQNLSILRDQKYITSQAHDQILGILPSNLSVQAAEQGYPPRKSPGNIPSPNPRPNSSLWSVPQPPPRRTPGAEVNDLKKEFPVPKPLVPTAGNYNYNPEKAAPPAMPAPEKEPEVVPPAYSVASAEALYDYHGQDKEDLSFRKGDIIEVTEFVNDDWWRGRVHGQTGIFPQNHVVKIETQNKTNRAQPPPPPPPPPPGASPFGAPAPLANQYSGASTSSLPYNYPPPPAMYQPPPASGNYMPPPPGQAVYAPAGQPEVAGEDSKGKRFAKKFGSQVASGAAWGVGMSGKQHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZX7</accession>
    <name>A0A8H7PZX7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZX7"/>
    <dbReference type="OrthoDB" id="2354828at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2182479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="298" mass="33869" checksum="45F08C68FE66E3BF" modified="2022-01-19" version="1">MVEVLQEDNVYTQSRTDAILCTVFYIWAFAAFIFLLNRIAKDIHFHIRNPFRLSGLFCNVLTLVQATLFVYSVVRLNTPRYLTIVFFVCRMVFVIVTSVNQIVTGRSLGQSYLKGWYVTFPLLLTFIAYLAADLACIIIVPVQNIDAAPLWLYTIGSVLCLTHLFLANVFALLPLLRSQPDHDLDAFNCGTSLWHVTCFSIILFGFLAAYIVSFVRSDVWYTISFISVEGILRVCCQFVYGAKAPKWAQKLLLNHLAKLFPVDIIFAPQVVEHEVTQEQEEMSICYDNQGGKHVLAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZZ8</accession>
    <name>A0A8H7PZZ8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MutL C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007148</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZZ8"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF47">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="3">
        <location>
            <begin position="483"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="373"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2182221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="782" mass="88906" checksum="67E84F9F23DB5A89" modified="2022-01-19" version="1">MTQCVLELLYNALDAGARNITVEANTETYVLVVSDNGCGIPSSEVAKLARRNFTSKCQSWSDIQGLKTFGFRGEGDGPSRGVSFATLEVITKHNDSHDTMHGIWRDGEMISLFASKNEQKMHAGTIVVARDLFYKHPVRRKQMQLELQQRASANNDKVLNDIKRSIEKLALCRFQVSWTLIDLSSQSKVMVAKPCDSSFKMFQHLYGYDLTQDGKRHTLDEGGILIDGFISPRLHNIKIYLLVTTDVNDQLIRFGGAYNALDKLLRQLIGTNDALGQYLLPTLYHLISFQLPTHSKAAKPNQNHPLYLMAIRTSMGTSKAKDLLEHYADESELVNDLQLCINQYVHEALNIGKQTTNETAISDHPQQAEILRFPGTGLSSHYTSKRGRHTPDDYEAISRKSFRYESHNSESSRALHQQQEEHDGDVQNDFQQISNVHLTRIEHQNSMPASNQQDVFFHHFPRIFRYEGLPDTLSSDLLLNAKAIGQVDKKFIAFQISGKRFEDGNDDIKSMIVLADQHAVDERILLEKMFRNFMDVMTTTPSTSDSGTSAVGSILLSPPRKINLSPIEVSKALRYRSFFIKWNIYYVDAGVYQSEEHVATKSSIGESTHFRKVHSSSSYFKRDTQQATSTDGILVSKIPRIISDRCATNPALMKQIIFEHIDWLESQSSIQQLVESHESRDKPESWNRKLRDCPRIIIEILKSKACRNAIMFNDALSKNECQKLIDLMSECVYPFQCAHGRLSMVPMIKYNTHGADQRQRLAQQPSRQRKLTFERFITTDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0Y0</accession>
    <name>A0A8H7Q0Y0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0Y0"/>
    <dbReference type="OrthoDB" id="2368669at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2183358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="35445" checksum="3CA5E210100A0B7F" modified="2022-01-19" version="1">MTCQLLFIGDILRASPQDAHRASGQTYTGNFILDIRNTSTLEFQNVRVCGTIVKTNFISRSDDFVFDNALEAAKPPDTITLDDGTATIVVTCSARVRNRADADLLKVGTTATIIGQVQMRQDNKLVECKGFDIHLDPTYEIVHGLRVIQTRNLRVNLSSNPSIIASQLSVLSQDTPRLRRALQSQNMPVPSPSKPESSGIKISEIEVREKRPNPLTDDNFDDSLSAEDLDSLMNAVDKRQKVEHNCLPSSQDNFGDSLPLASQPDNETTQRVLGLLNHKGMTLKDFILAGLDFMAVEDSLSYLLGTGQVYEREERYYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q144</accession>
    <name>A0A8H7Q144_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">P/Homo B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">INT43_006454</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q144"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007323">
        <property type="term" value="P:peptide pheromone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000026">
        <property type="entry name" value="proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000005">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 14" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034671947" description="P/Homo B domain-containing protein" evidence="17">
        <location>
            <begin position="20"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="741"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="18">
        <location>
            <begin position="503"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="653"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="787"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="664"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="686"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="787"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="806"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG2183448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="833" mass="90946" checksum="197295C035FD6304" modified="2022-01-19" version="1">MVRLLALGVISVALQLVFAAQPVPRNYNDRLYYTLHSPSGNHEAAEHTAQLLNARFEGKLGELDNHFLISVDRRSIQSRSEDDEYAHTLAAFQSLAQEHSLNKRSLNHISAISAIESQKPQRRLVKRIPIDTLAERQDPPVHENQSEEEAANAKPVTSWLEKPGAYLAMKSKLDIKDAGFDNQWHLVNREQYGNDINITGVWEQGITGKGVVVVLLDDGLDYESNDLKDNFFAEGSYDFNDHTPLPKPRLFDDNHGTRCAGEIAAVKNDVCGVGVAYDAKVAGVRILSAEISDADEAEALNYKFQENDIYSCSWGPPDNGEVVDAPKGVVYDAIVNGINKGRAGNGTIFVFASGNGGAFDDNCNFDGYTNSMYTITVGAVDRLGNHPYYAEKCAAQLVVTYSSGSNSRIYTTDVGKESCTDSHGGTSAAAPLAAGVFALVLSIRPELSWRDMQYLCVKTAVPISLDDDDWAHLPSGRMFNHQFGYGSLDAYRIVEEAKTHQKLRPQTYLEVPREPQHPQPIPDLTGHGHVDITKALTSTIPITADMVKAAGLSKLEHITINVDIEHERRGDLEILLESPHNVTSQVAARRRFDVSKDGFANWTFMTVKHWDEDPVGNWTLRIIDAFNPQETGKLIHWTLTLWGEIAVDMTGEPNHRPVAGALPTSTAQSSSETSATQSVEEISASPVATASQSDTTTGGTSPAAEPAQTPNADHIDAELETSPAVNGTNVPERIVSTGSTVAYIAVGSILILAAASIAYVAKRKAWAEKGYREPPMSNRTEGYEFDLFVDDEGSEEEEEEDDIDDGDSHAESPMLGRDKGKGKMVHQTGTDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q161</accession>
    <name>A0A8H7Q161_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q161"/>
    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="5"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2183154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="136" mass="15079" checksum="2279B4CA4C390184" modified="2022-01-19" version="1">MSLVPRNFRLLEELEKGEKGIGDGTCSYGLADDDILMHNWHATILGPGHSVHENRIYSLKVICGEGYPAEPPQVQFVSKINLPCVSSSNGKVDNHKLPCLANWRTTFTLETVLTDLRREMATTGRKLPQPAEGTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1C6</accession>
    <name>A0A8H7Q1C6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pumilio homology domain family member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_006263</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PUF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1C6"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000004">
        <property type="entry name" value="Pumilio homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="9">
        <location>
            <begin position="649"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="669"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="705"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="741"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="777"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="813"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="849"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="885"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="924"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="375"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="482"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00081811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2183259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="985" mass="109721" checksum="015818C3AFC2AE9E" modified="2022-01-19" version="1">MLPNRPNSRSDEQLKQSSSSASQKQDSIRQPTATIHPQGQLAALLRDRLDDYDPFTSNGLAGRNNNGPDQMHIRSNSAPTTPAQTGNVTSHHPDDVLNADPRFNIDPSGPQMGASRYDTRRSGPNQDMGQSWRLWQSPSSNQNESSDKLSGHEYDDAYNPLQARLRSPSSDTTSTKKGRKMADIFQEGYPQSSSTLFTSMGMESDMKPSQYREKFRSHLDFVEDNSSPIGRGFGGDSNSSPLGFGNLPSQHQGYDESGYKSQGPKGAPMRAFSPPLHQHGSPSQQPPRANSTPPIHNVGFNASANVENIDYMNGDPTSLARQFQNLDMNSDYYGFQQMQGSQQGPSDYQTSFHGRQIHTTPGSPEKFNVAQPLYGRHMHMNPPSPGPYNQGHASHGGRQTHTNPGSPEPFHVQNQFRYRLPNAGMSSPPPPLSAGHEYAAFGDVNQQQKRPADSYNMYRAWNLDEENLNRNLKNTDLGYMDHQKNKNNGAESYGQQQPFSPAPGMSPLGNFGAGNRNLMNGQDYMNISNSHFANSATGTPSIASAAASMGLGSLSTPLTAPAGFGGPTKMNVQQGPESSKLRSLQVQQQQLLLQQQQQILAAREQMYRQQSQPEFLTQQPAMQPSYSAVTRSKNSSARAANQSDVGTGMRSQLLEEFRNTKNRKCELKDIAGHIVEFSGDQHGSRFIQQKLETANSEEKQLVFEEIIPNALQLMTDVFGNYVVQKFFEHGSQMQKSILAKQMEGHVLTLSLQMYGCRVVQKALEHVLTEQQASLVRELDGTVLKCVRDQNGNHVIQKAIERIPGSHIQFIIDAFHGQVYSLATHPYGCRVIQRMFEHCKEEQTGALIGELHRCTAQLVQDQYGNYVIQHILERGRPSDKSMVVTKIRGQVLQLSKHKFASNVVEKCVDYGTKEERQLLIEEVLQVRPDGTYPLAAMMKDQYANYVVQKMLDVVEGEQRDLLVNRIRPHIPSLKKYTYGKHLIQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1W8</accession>
    <name>A0A8H7Q1W8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1W8"/>
    <dbReference type="OrthoDB" id="9988524at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF10">
        <property type="entry name" value="PROTEIN PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="243"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2184602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="393" mass="43538" checksum="0438FB4910986C54" modified="2022-01-19" version="1">MLSTDNPSATVENNQVNYPLKDEKPSVQAENHLSQEQDKTTVDDATAEATLTEPRKFENIANFRDVGLSCTAKDENGLQRTEGKIGNILADAFPASAIAAVKPSEMVLAPMLPPHIEEKLSKLDSRQVTMTSETIKKGAMHAADNRKESRRKSNVVVMDNLRHEISNTKEGATTRITYFVNFAGSKYRYHCVLKPCPFLLKLRVFGLMIIGRKPEAIRLIGTRVLQPKGLKGLNRDFIDFCGEQIIQAIRILLASATYPVLVHCTQGKDRTGLVIAIVLLLCNVPRDLIVKDYAKTQQGLDAQREVMVAEMAKNGLDPSFSDAPADVIIDALDYLESKYHGAENYAKLQGMRDDEIRSLRVIFVAEGTTKQANVHNANTVVALRQNGYENLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q237</accession>
    <name>A0A8H7Q237_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Right handed beta helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q237"/>
    <dbReference type="OrthoDB" id="3432466at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034817993" description="Right handed beta helix domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Right handed beta helix" evidence="2">
        <location>
            <begin position="243"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2184517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="675" mass="72103" checksum="E62A4EB1B6BAAE87" modified="2022-01-19" version="1">MRLTMLAGIIASLSNAMVLSAAASTSYYVDCSTSSNGKGSVDSPFNQLTAASNQQLGPGDSLLFKRNATCQGQLTINDSGSIGSPIVIGAYGKGFDLPVITAGNKTNAVLLNATSHIVIENLELTNPIGNTVRKRGLYIYAADAGNITDITVQNLYINNVRGLMPSTISPFNAANGKYANATGGLVIEAGGNTTSTWFSNILIQNNTIRSVDRQGIYTWTNWCRRPAMASFWDTLCFQPWAPSTGFVVRNNQLYDIGGDGIVVKGYVNALVEHNKLIGFNKRSNSPNAGMWTANSDGSLFQYNRASGGTTTSDGMAYDVDHSTSGTVFQYNLSHDNEGGFFLICPYDKPTQDFIIRYNLSVNDKARGFEICDGALVNGSIYKNTILIGSRITSNLVQESTNASLDVHLVDNIVRKSGSGAVNWQLSDPKFIVDHNAFYGVSSYAYATNTITSPPGLAMPGVRDPKGYFLVSGYPTLGAGIAVSDDASQDFFGNPVASNTKPNIGFYAGPGTNAANTSDLFDSYNIGANSLSGWNSTGNIKIIADPAGDLGNSLQLSGGSSVKRSIFGQKNFRLSVLFWANQTNASFEIDLIGSGKILVSIPFSSSGQFGSLSYTPNEWHLVELDVNTSSLLAQPSLDSQTINSIKYAGIIDSVQFKAEIFADALFVVDDFYIVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q277</accession>
    <name>A0A8H7Q277_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q277"/>
    <dbReference type="OrthoDB" id="2289168at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="198" mass="22185" checksum="D40991E5DA64C744" modified="2022-01-19" version="1">MLNSEPISPNEVTDDHGYIGPHFIDLYNDLYDQQMMAFDSLLPLSDPYPMVDASQYDVCYPMMDSLYLDPNISTQALTYLEGPVAAIRPKKKTNASSCATQCQHPKHENYATLANANLSTVTPRRGRPPKGSKCSDIFETAQLKRLPKRLESVVGRQEIYVCLTCLRRSDEDIEYVTSPNYTPPISGRSGRIKRTGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2G4</accession>
    <name>A0A8H7Q2G4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PUA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_000510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2G4"/>
    <dbReference type="OrthoDB" id="409889at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21157">
        <property type="entry name" value="PUA_G5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000018">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF3">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="294"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2184601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="395" mass="42651" checksum="9C3E41802C0C2FB0" modified="2022-01-19" version="1">MVHRNIQNTHRPTKSSLTLVIKVGTSSICDEKTHFPLLGNLSMIVETIIKLKSLGHRVVLVTSAAVGTGLRRLNMPNKPSKLASVQAIAAVGQGRLMAIYDDLFGQFNQAVAQILLTRNDLADRSQYLNAVNCLEELLDMGVVPIVNENDTISVSEIRFGDNDTLSAITAGMVKADYLFLMTDVDCLYSDNPRTNPEAAPVKVCDDIEGLRERITVTAPGSSLGTGGMVTKLIAADLATAAGVTTIITRGSKPDNITQIISDSANAPLHTRFVAKKTPLMDRKWWILHGLHTAGTLFVEESAAKDIAGRQGGSLTATSIVKVSGNFVSNQSARIVVEKMNSDGEMEIVTVAKGIVNYSSQEIERIMRCDAEEISKILGYEDSDSVVHRDNMAIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q384</accession>
    <name>A0A8H7Q384_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_000407</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q384"/>
    <dbReference type="OrthoDB" id="332390at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013136">
        <property type="entry name" value="WSTF_Acf1_Cbp146"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075:SF6">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10537">
        <property type="entry name" value="WAC_Acf1_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51136">
        <property type="entry name" value="WAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAC" evidence="3">
        <location>
            <begin position="26"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2184498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="100" mass="11986" checksum="6A999CB83CC737E6" modified="2022-01-19" version="1" fragment="single">MPILQHSQTHLPAIAPPPYDSKRKHKEVWNLRSTNEIFTDYESYIERLMQYRLPQWQCERTGRADLTYDQAKESENAQNSRAEYRFSFGLAKRVFQCVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3M9</accession>
    <name>A0A8H7Q3M9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phenylalanine 4-monooxygenase</fullName>
            <ecNumber evidence="4">1.14.16.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phe-4-monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_000621</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.16.1" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3M9"/>
    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004505">
        <property type="term" value="F:phenylalanine 4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04880">
        <property type="entry name" value="ACT_AAAH-PDT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03347">
        <property type="entry name" value="eu_PheOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.800.10:FF:000004">
        <property type="entry name" value="Tyrosine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="entry name" value="Aromatic amino acid hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018301">
        <property type="entry name" value="ArAA_hydroxylase_Fe/CU_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041912">
        <property type="entry name" value="Euk_PheOH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019773">
        <property type="entry name" value="Tyrosine_3-monooxygenase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="AROMATIC AMINO ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473:SF24">
        <property type="entry name" value="PHENYLALANINE-4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000336">
        <property type="entry name" value="TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00367">
        <property type="entry name" value="BH4_AAA_HYDROXYL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00858">
        <property type="entry name" value="PREPHENATE_DEHYDR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="14">
        <location>
            <begin position="11"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Biopterin-dependent aromatic amino acid hydroxylase family profile" evidence="13">
        <location>
            <begin position="83"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2184708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="429" mass="48525" checksum="A46B39D27CF537A5" modified="2022-01-19" version="1">MSPASNTLTCNLHFSITDGIGKLESCLAALKAMNVSLTRIESRPSKTSDSEYDFFIEFQAENQSQVVEVVESLKKHSTQVRVIGSGTAGQGETSVPWFPRKLSDLDSFAEKVLEMGEDLSADHPGAQDPVYRKRRTEIVQIAKTYRTGQPIPHVEYTQQEVETWGAVFRKLTAMFPDHACREHQHVFPLLVQNCGYNDKQVPQLEQVSNFLKDCTGFTLRPVMGLLTSRDFLNGLAFRVFHSTQYVRHHSHPLYTPEPDVCHELLGHVPLFANPDFAAFSQEIGLASLGATDADLEKLATIYWFTVEFGVCREGEHVRAYGAGLLSSFGELEYALTDKPERRPFDPSVTAVQKYPITQYQPVYFVAESFKDAQEKVRAFANQMERPFTVKYDPFTQSIEVLDSKEKVVKYAQNIRDDMRNLAMALEKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q467</accession>
    <name>A0A8H7Q467_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_000908</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q467"/>
    <dbReference type="OrthoDB" id="10261046at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14834">
        <property type="entry name" value="AP3_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000001">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027155">
        <property type="entry name" value="APS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000804">
        <property type="entry name" value="Clathrin_sm-chain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00989">
        <property type="entry name" value="CLAT_ADAPTOR_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2184995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="168" mass="19051" checksum="A76D64A94CA2E337" modified="2022-01-19" version="1">MIFNNHGKPRLSKFYQQIDIATQQALIEEIFSLVSKRPDTVCNFLEGSKLLGGKDTRVIYRHYATLYFVFVVDESESELGILDLIQVFVESLDRCFENVCELDLIFHFEEVHHILSEIVQGGMVLETNMTEIVTAIGELNKMKKKNGAISAGSLSLKASETLRSSFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4F6</accession>
    <name>A0A8H7Q4F6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1688-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_000777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4F6"/>
    <dbReference type="OrthoDB" id="2153176at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012469">
        <property type="entry name" value="DUF1688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687:SF3">
        <property type="entry name" value="PROTEIN URG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07958">
        <property type="entry name" value="DUF1688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2184864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="50384" checksum="9D2DA8440E2B4D82" modified="2022-01-19" version="1" fragment="single">HPSMTIAHNPEDYLRSLPSIRDRCQLVYEKGQKNELQHFNINSEKLPVVVDYVKDVITKKYDSLDKIPPHSRWRHFDAGGYSRVQDLIDEWKNAGVDATERTRRLVDLFLVAVLLDAGAGMQWKYKDEVTGQVYRRSEGLGVASYNMFKAGLFSDDPTEQPHRVDVDRLQRLRTEDVSNGFQVHDDNPMVGINGRANLLNRLGRSIEQQSTYFPTAKDAVARPGNLLDYLLSHNSSENDTGKHIFHVPALWSGIMSLGEMWPARLKLNGVQLGDVWPCLAIKSPSAPPESTDHWVPFHKLSQWLTYSLLEAIEKGLNANFTGRESLTGLPEYRNGGLLVDLGLLSLKPDTMQRGIIRCREKKPELTGNELPMFESGDPAIVEWRALTVIYLDKIAEELRAVYKLDKETLTLAQVLEGGTWNAGRAIATEKRPSSDPPILIESDGTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4W5</accession>
    <name>A0A8H7Q4W5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_002600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4W5"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000947">
        <property type="entry name" value="serine/threonine-protein kinase OSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047173">
        <property type="entry name" value="STRAD_A/B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014:SF21">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="97"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="425"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="522"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="560"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="663"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="798"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="438"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="581"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="685"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="802"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2186162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="824" mass="90749" checksum="BD5EEA8F988574CE" modified="2022-01-19" version="1">MTWPDIATTQGQPSPDPSGKEVDGPSAQIPTPSQTPPPTSKERRHSVLGHATRRSFGGSDALNLLRLPSHHNQNSKDSAVITPAQQESHTFNNIDDFEIKNPIGYGSSAVVYGAIYKPLNKRVAIKMIDLDLFERNQIDELRRETALMALSKHPNVLRVYGSFVQGSKLYIITPYLLGGMYHVISATREMCSTICSCLDIMKTGFPEGFDEMSIATVLKQALEGLIYLHKNGHIHRDVKAGNLLMDEDGAVLLADFGVSSSLVETGERGGVRKTFVGTPCWMAPEVMDQAGYDYKADIWSFGITAIELATGHAPFAKYPPIKVLMMTLSNDPPTLVRENTKHKYSKTFKDMIDLCLNKDPTKRPTAEKLIQHLFFKQAKKKDYLAKTLLASLPALENRPHKKIPQKHPSITRTTTWDFDADELEDDQVKQSEQSEQINEDKGAESDQEIRNNEVDKTSDMEDKNGKKHITFGDVVVRNPPQPHMSPNAAAHSPPLGSSPKSNADTAVTAPKKSRFIIQETITPREPFDPLGTPPSTNSPILSTPPELASHDESNALLLGLGMTSSMTPPPSEGSMRKGRFSVNSTPRQSISGESNFAPPAEVSLNKDTTLSRINSQENIDRKSRFEIMYNQLPGSPNLPPIPNGSVIARSDIIPLSREGSLSSSAAAPSLHRESSENARVSRFSVVEKDGDGKEPQEIIRDQSRTPTSNAVHPSDTPHLPSHQHTPSIESRKVGRFELTAGIPSGYEVKSGEGTYCIKSIAHDAATSMDSLQQQVEQYVRENESIRRENEQLKKEIEKLRKTSQVSVPDSSRTNSASSSEDSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5C7</accession>
    <name>A0A8H7Q5C7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase II subunit beta</fullName>
            <shortName evidence="3">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_002283</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5C7"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000003">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000002">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF39">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034262463" description="Casein kinase II subunit beta" evidence="4">
        <location>
            <begin position="17"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2185845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="236" mass="27649" checksum="3E9033589E93357A" modified="2022-01-19" version="1" fragment="single">HLILLSTLLVDDLSSGSDSDYTKYWIDWFLNTKGNEYFCEVDEEYILDRFNLTGLNAEVQHYSQALDLITDNLVEEEFDEDMRDQVEKSARHLYGLIHARFVITSRGLAKMLDKYKKAEFGRCPRVLCHNQPLLPVGLSDVPHSKTVKLYCPKCEDIYSPKSSRHAAIDGAYYGTSFPHMLFQVYPNLMPQKSTERYIPRIFGFKVHEIAKVHRWQDQLKERLEDQTRQNSKEQHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q624</accession>
    <name>A0A8H7Q624_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q624"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46546">
        <property type="entry name" value="SHEWANELLA-LIKE PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46546:SF4">
        <property type="entry name" value="SHEWANELLA-LIKE PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034987157" description="Calcineurin-like phosphoesterase domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2186220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="306" mass="33913" checksum="1576CAE5FCA6687A" modified="2022-01-19" version="1" fragment="single">MQLQTFCFVALACAITKVICQEPIRIVAVADLHADYDNSVAVLQMADVVDENVKWKGSNNTVFVQTGDVVDRGADTIKLYDMLQRLRDEAYESGGQVIPLLGNHEVMNLIGDWRYVYPEDVQTFESFDARVKAFEIDGFIGSYLSQLNMTAKVNRTIFCHGGIHPAFLHDESGLDWINSYVHENLPEYMQSKGTEGDDFGVFGGNGPTWYRGYALGPEEQECPLLEAALDLLDADRMVMGHTVQHDGKVHSRCDGKAILLDVGISKAYGRNRAALEIIGDKVVAINDGKRVEIVSTGKKYPSKLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q654</accession>
    <name>A0A8H7Q654_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_002703</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q654"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045072">
        <property type="entry name" value="MKRN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224:SF10">
        <property type="entry name" value="IP09428P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224">
        <property type="entry name" value="MAKORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2186265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="364" mass="39724" checksum="3C95AE40EBD17992" modified="2022-01-19" version="1" fragment="single">KPLFVGNHSLTVNLASGTSNIPCKFYKNAACTAGANCPFLHSDNVYHAATTVCKYYLKGNCKFGSKCALLHSLPESAASISSGGGRTLTRGTSADNIVNSYGWESGHLYETSKIDVQSSDDSDSYFDAFDPRWQDGSSISNSFANVDSILASPVRFNSTSIEQPVTPRNRPEENNAIFVKGSSVHGFLHSPISQTAYIGSLPGSSYYNDGWSSFSATSAKSQDHDYSENPMLTSSFDEIVASDNSRKSIHPTAIKAIKRPSQIGISSLSSSPSNTGLFGSSFTDRLNAIASQSYELEITKDILRVRNDRRRASDPSIISRRTELCKSESLGHKSECDMEDCVNDTEKDMEEGPFIMDKDFDDYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6G1</accession>
    <name>A0A8H7Q6G1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin/Vps5-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6G1"/>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030905">
        <property type="term" value="C:retromer, tubulation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053055">
        <property type="entry name" value="VPS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="1">
        <location>
            <begin position="10"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Sorting nexin/Vps5-like C-terminal" evidence="2">
        <location>
            <begin position="135"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2186430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="42262" checksum="F5DB5F5F98B77534" modified="2022-01-19" version="1">MESNLRSYQHKTGRGERTYSEFERLATHLTLVHEDLFVPALPDMTVSVIAGQRPEDEDKLLLARMQRWINLITSHPVFKYSDLVKEFAESGQGFMPTVKPQSFHRHPSRFQLMKGGLGLSGGAPADVDNEYISLTNQIQAFSQGLQAVSKAVQANFKCRKALSTSYLELGNKMGTFSEKENNAIIQNSYRRMADALQECGELQRPQAQAENALLTDAVAYQTKNAQIAKDALDARLAGISQHHESTKTTESKLKTMNKLKASNSIKSARVNDAIEDMQEAKAQEQEVYRRCEKVNLNLKKELSGRYKTQVTEDITKTLADYVKAQIQYERQMLQKWEGLQHSQGMSVNRTSRWREGSIEGRIDERKAAALLGTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6K3</accession>
    <name>A0A8H7Q6K3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_002693</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6K3"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="11">
        <location>
            <begin position="90"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2186255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="296" mass="32835" checksum="D280AF192C15B31A" modified="2022-01-19" version="1">MPVFLTQQLQKSDQLAGKKRKADVQTTGSGKVAKSTTTEVKKPAKEDLWFADDIDEEDFKRAYGGAEKVSKEDLIQTMNESTGSQAKLGKYVAIDCEMVGVGPDAEESALARVSLVNYNGALLLDEYVKPLERVTDFRTAVSGITPKHLAQAITFKEAQQKAADIIKDRVLVGHAVYNDLKALMLDHPRALIRDTSRYKPFRKHAKGRTPGLKLLVKEVLDMSIQTGSHSSVEDARFTMLLYKKVKTEWDRSLSTQKSRELKLIKNGKNKKATIKKTTTVSISKPAAADMADSDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6R5</accession>
    <name>A0A8H7Q6R5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_002196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6R5"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2185761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="130" mass="14345" checksum="722B25524B71D951" modified="2022-01-19" version="1">MVLKPTILSITAAVATYTAEKTTMELNIFDINDGDVEEQYEISPTSSSSTSDPAEYHKACNQYDHLRSNYSINQRFGISNLIANIVPSGDAAQRVSKVTERRIMHVSRSPFAFVNGIMDGNTNLNTVLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q788</accession>
    <name>A0A8H7Q788_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA mismatch repair protein S5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_002469</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q788"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="4">
        <location>
            <begin position="261"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2186031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="464" mass="51655" checksum="7EAEAC6F2C59AA33" modified="2022-01-19" version="1" fragment="single">MSKAIKAIDESSVHRICSGQVVLDLATAVKELVENSLDAGATAIGKCKKILKTDNERHSILSLRMARYIDVRFKDYGVESLEVIDNGSGLDPSDYETLGKCPCSAKFKLFMSLIAPALKHYTSKISKFEDLEEVATFGFRGEALSSLSALANLTVTTSTATQSPTGYRIEYNVNGRLKTKQSIARSTGTSIQLTNLFHSLPVRHKEFKKNIKREFTKALNMIQAYAIISPNVRIVASNQLSKGPSNKILNCNANKTIRENIANIFGAKAIAQLMPVDLTLPENQIKMMEDQGNDDSKQIKIIGFITKPIWGHGRSSADRQYMFINGRPCSLPKITRTLNEIFRSFISNQYPFAALDFRIPNGEFDINVSPDKRTVFIHNEKWISDQFAVCLVNYDSGRLAAYTYGTLYRLQEQLNQLLEPSRYTLPTNELTGSTDLVDEPAAIGNISESTSKPLESEMDYSSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U720</accession>
    <name>A0A8H7U720_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_000138</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U720"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034463220" description="GH16 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="36"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2172791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="295" mass="31565" checksum="18CFACE20CAA0C60" modified="2022-01-19" version="1">MTRILVTASLLLASLLTIVIADIPPATNGFSLIWGDDFAGPANSAVDSEKWQHDIGGGYPGGAPNWGTGEIQQATNNIANSFQDGNGNLKIVPIRDDHGTWTSARLESIRDDFRAPPGGVLAVEAKMQLPDVSGPAAAGYWPAIWMLGAPYRGNLHNWPSVGEFDIMENVNGLNCVWGTLHSAASPGSNQDREFGSKLLDISPSLQSAPHTYRFELDDAAKEMRWYVDGKQYFSVSSSQLSAQTWTDVTNHGYFIILDVAIGGNMPAGAGGGPTMATQSGIPLTVDYVAVYQKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7J6</accession>
    <name>A0A8H7U7J6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7J6"/>
    <dbReference type="OrthoDB" id="2371217at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034947201" evidence="2">
        <location>
            <begin position="20"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2174246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="383" mass="43120" checksum="BB3AC9EB556178A4" modified="2022-01-19" version="1">MRSLLYISTLVLAGALAYAAPIPYNPNAPALSQDIENLFQYISSKDSSADISEKHQIEQDIVTLQDGTDKNSQEYRTALDTFWTDLGGLWVKYPVWSGWSTLQSDIAEEAWTKMENDQHMNEASTVSFTETDSFESDLDDLEEYVKEHDVASTSDVYIIKQAILWLKNHEHNIDTAHDFVEQATNADEAWGRLQKNNPDWSKWTQAEQDFKGDWSQTLQHVSNSTLSNLYAEENSHNNDVQYEDLSSFFEAPNHTNAEVEYEDLKSFFDTPSHTNADESTPDIADVDELINDYFSGSDTAHTNDLYSDNTSTADPTKPEYPVSDNTTSTETTTDDLASNDGVYMDAYLDDVFAKLSAPDDGSHADHTDGLSEVVGNWNKYDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U815</accession>
    <name>A0A8H7U815_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_009028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U815"/>
    <dbReference type="OrthoDB" id="1711508at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="3">
        <location>
            <begin position="45"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2171367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="257" mass="29804" checksum="CEA93C336FDC44C0" modified="2022-01-19" version="1">MASIPARTAQRVARNMPKARSEPAKEKVASQNYIAHTEIPSVTCTERQRQLIILDLNGTLVSKTGKAGMWVRPHYQDFLSYLFRNFEVCVWSSARQKTVKNMCQLFGDHKKQLSFIWSRENMGLTKEEYFSNISTVKDLQLVWKHYSKQAGSNIYNANNTILLDDSITKAILQPCNSIEIGTFNHKLSTTKINGDSELLDVINYLEKVQYQSNISNFFKEHPYETKPTYTAHDTNFQFTYYRFNSDYVMTEDSRKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U896</accession>
    <name>A0A8H7U896_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008062</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U896"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="7">
        <location>
            <begin position="20"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2171682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="120" mass="14052" checksum="DC0753D7396DAC81" modified="2022-01-19" version="1">MCNFLEYKGIVSIVQCPIISQDTKIVYRRYASLFFVAGINQDDNELITLEVVHRYVEILDRYFGNVCELDLIFNFNKAYFILDELLIAGELQESSKKSVLRVITQQDQFEEQEANEQRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8R2</accession>
    <name>A0A8H7U8R2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8R2"/>
    <dbReference type="OrthoDB" id="10313342at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2172447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="130" mass="15397" checksum="335E16470639AA07" modified="2022-01-19" version="1">MPFASYLLNKKKKVTPFVELRRPKTWHICDRCLTSYDRFQNFEMHVDKCSLSKCWLIGPKYLQLATTEQDNMTKNKKKDQNTHIYYGQDHTRFDMDACNDKPTWLNNLHKTSCKVALFLTTRFSAAVHTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9D0</accession>
    <name>A0A8H7U9D0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Lysosomal dipeptide transporter MFSD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Major facilitator superfamily domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">INT43_004616</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79415"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:79367"/>
            <dbReference type="ChEBI" id="CHEBI:229968"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:79375"/>
            <dbReference type="ChEBI" id="CHEBI:229967"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79383"/>
            <dbReference type="ChEBI" id="CHEBI:229966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79371"/>
            <dbReference type="ChEBI" id="CHEBI:84315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-arginyl-glycine(out) = L-arginyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79391"/>
            <dbReference type="ChEBI" id="CHEBI:229955"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79411"/>
            <dbReference type="ChEBI" id="CHEBI:229953"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79379"/>
            <dbReference type="ChEBI" id="CHEBI:229964"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-histidyl-glycine(out) = L-histidyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79395"/>
            <dbReference type="ChEBI" id="CHEBI:229957"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)</text>
            <dbReference type="Rhea" id="RHEA:79399"/>
            <dbReference type="ChEBI" id="CHEBI:229954"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79387"/>
            <dbReference type="ChEBI" id="CHEBI:229965"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79403"/>
            <dbReference type="ChEBI" id="CHEBI:229956"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-lysyl-glycine(out) = L-lysyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79407"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="24">Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9D0"/>
    <dbReference type="OrthoDB" id="424834at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="26">
        <location>
            <begin position="50"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00044985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00045018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00046376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KAG2173242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="562" mass="61961" checksum="851F92D50938BB45" modified="2022-01-19" version="1">MRSIDRNRQASFSSSLTRIESITSCQTETDPLLPFKHRCNNGELTIRHWALLFFACAFLFGNYFCYELPSALNLQLNERMGTPYDLWQYQLNMLFTAASMPNVICPLLAGIGIDRLGTNTMLITLTTLLCFGQAVFAYGVYIRSFWLMVAGRVAFGMGGGSLEVCQGKITTEWFRGRALAFAMGLNLTFGRIATALNYNLSPWLDAKFSEAFVCWFGFGLCVLSAGATVITIILDRPESRAKAGLNRPDAVRVRKPIMNQTGMPNDLLFDSDACSVFSQDDHINWSHLATFGLSFWLLNIILLTLYGAVQPFMHIASDFLQTKWYHGDPQTAGAVQSLPDSLSAFMSPLLGYMMDRIGHRGHTLLLSGFVISISHLTLGLTTFNPIIPLFCLGIFYSAFASAMWPSISLVVEHDQLGTAYGISTVALNIGLSVVPIMVGRIRAISTFTHVELFFAILGSIGTIAAFLLVLVGRREGSPLEKVHVDEQLLDSPRDGGITTRWVTEGRHTMVPHRYSTTSWIDDDGAIHHVIGGTAPGVVAVANINNDEYNNIENYNSIATQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9Q2</accession>
    <name>A0A8H7U9Q2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">INT43_005005</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9Q2"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000073">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000085">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000005">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034229641" description="T-complex protein 1 subunit gamma" evidence="16">
        <location>
            <begin position="29"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="948"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2173587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="967" mass="106261" checksum="FA6E4D54CD421C18" modified="2022-01-19" version="1">MSEGQPFPSTWKLVLSFTFALVVANVSGAQYVYPSFGTALAEHFQWSAMENSFVSTATFLGVSFSGPLCAKLVETFGDAHALRIAATFGFTGFFLLSQTFADILPNSFALCVVYLLMIGIGGATGYLVALDSQVHNFRAHRGLTMGMTSAALSLCGLVFSQINDHFFKEDSDTYSFLIFMAFVVAGGQLAGSFIVRSFNHDHEATSAVINADEEATPLLNPSVKEEEPSKSGWRFFTDPIGFSLFLSLFVLLGVGYVYLAELGQILLSLPTEEGSTPHHIRNNNVSVFSFFNFASRIVFGLMSDSLKARFRIHRIWFMLTACLVLAATMFYGAFYVTNAHDLIPCTILVATTYGTGFGIGPAITSEFGIDVFARNWGWLLFAPAFGTQVFSFIFGAFYDYEARNQDSHTCQGSACYGRTFVLGGILALLSAAWTAGALIRRRSLTTRSNPSTVADVIRTCLGPRSMLKMLLDPMGGILLTNDGNAILREIEVAHPAAKSMVELSRTQDEEVGDGTTSVIILAGEMLAQALPHVQRNVHPIVIISAFKKALEDAIQVIDDISVPVDINNQEEMLQLVKSSLGTKFVSRWSDLMCNLALDAVRCVAQEDPSTGMREVDIKRYARVEKIPGGEIEESKVLDGLILNKDVTHPKMRRRIENPRVVLLDCPLEYKKGESQTNIEITKEADWNRILEIEEEQVKAMCDKIIELKPDLVFTEKGVSDLAQHYFVKANITAIRRVRKTDNNRIARATGATIVNRVDDLRESDIGTQCGLFHIEKIGDEYFTFLTKCKEPKACSIVLRGPSKDIINEVERNLQDAMCVARNVFFNPRLSPGGGATEMAVSVKLAEKAKLVQGIEQWPYRSVSDAMEVIPRTLIQNCGGNAIKVLTQLRAKHANGEHSFGIDGHEGKVVDMKEYGVWEPNAVKVQTVKTAIESACMLLRVDDIVSGVSKRGGGGPQAGIEEAELAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9S1</accession>
    <name>A0A8H7U9S1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation factor 1 alpha-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_006012</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Dom34-Hbs1 complex, also named Pelota-HBS1L complex, composed of dom34 and hbs1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9S1"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04093">
        <property type="entry name" value="HBS1_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000070">
        <property type="entry name" value="Translation elongation factor EF-1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="91"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="36"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2174950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="525" mass="56851" checksum="11F5623D35665FEE" modified="2022-01-19" version="1">MTKKPSSQAKSIDEDVEFLEDDDDNQMDFDMAALNLGEKKTKTAKPKKVSSMASTPANSQPSSPKVSPLAKIPASKRVDVEAEYAKRSSEKAKLNMVVIGHVDAGKSTLMGHFLYALGQVSDKTIKKYEREAQKIGKSSFAYAWVLDETGEERSRGITMDIATNHFETKSKQFTLLDAPGHRDFIPNMISGAAQADVAILVVDATTGEFEAGFDANGQTKEHALLVRSLGVQQMIVAVNKLDVMDWSEARFEEIKAKLGTFLVQAGFRKSKLYFVPVSGLTGENLVSRSADTPLNQCEPFLIYESRFLDQFEPPMRPLDRPFRMAVSDFFKGGIGSSSGVSVAGRIDAGHVQVGEQVVAIPGGETGIVKTMQVNDETANWGAAGDSCLMTLTGLDIMQLSSGTVLCTPSNVVPVTSHFEAQIVVFDIKVPITSGFPVILHHQSLNEPASVVKLVAIIDKSTGEIIKKNPRHLSKGSTATVRIKLANRPIPLETFKDNKDLGRVMLRKGGETVAAGVVTQILSFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9S7</accession>
    <name>A0A8H7U9S7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Centromere protein X</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_005082</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-X/MHF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9S7"/>
    <dbReference type="OrthoDB" id="2500381at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22921">
        <property type="entry name" value="HFD_CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018552">
        <property type="entry name" value="CENP-X"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680">
        <property type="entry name" value="CENTROMERE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09415">
        <property type="entry name" value="CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2173662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9362" checksum="3C6EF1F02B4BF86C" modified="2022-01-19" version="1">MEEDNVLTFKNETINSVFKTQWKENGTKANKDALVLATELMRIFTVEAVHRAVDEANKDAGGGSQTLQVEHLEKILPQLMLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9T9</accession>
    <name>A0A8H7U9T9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">O-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_006057</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9T9"/>
    <dbReference type="OrthoDB" id="10251242at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF14">
        <property type="entry name" value="CAFFEOYL-COA O-METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2174995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28907" checksum="D5ECDBC5D7A3BC9D" modified="2022-01-19" version="1">MLYAGLPTLAFKRFLNTSTKPPSNLQQYVESMTSCASTFPQALIESLEAETRKQFEDAFKMVSIHQAHLIYNLTRMIRPQNVLEIGTFTGMSTLSIAAGTDGNILSIDRDAKPINIARMWLEQAKVADRVIIEEGIALDIIKKLPTGAFAPKFDLVFIDADKGNYINYFNQIMSRSLLSDRGIILVDNVLFRGLVPNAMENNFDPKDKNLIRTARKLHAFNQHVKDDPRVEQIILPLFDGLSIIQRKPKLSCVLPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9X3</accession>
    <name>A0A8H7U9X3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_003003</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9X3"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF3">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="164"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2177756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="384" mass="42692" checksum="C8F11260325EE368" modified="2022-01-19" version="1">MKQSEGPIHLTGQSTLATPTDEPSDTDNNSTDNLPSNSDWQMVDDNVELLQHPSEPEDEPPLTVRTTNWRSSIQDFIGSVRAAITPYATGERSVRDLLYRYRYVVAFLVFSWIMGALFWAFKREIFEGLETLSHVVEGMGAGGYALIGSLIFLSAFPPMIGYGTYQTLSGFTFGFLRGFPLSYFGALAGSVTCFYLSRRFLKKRVLRLVAKYPKLEAVVHAVEKKGFKLFVLIRLAPYPFNIMNVMFAATDISLATYTLGTAISLIKIGIHVYIGATLPSFAKHILGEDDDDPVDSGAQIFRYTAMILGTILSMGVMVYIYFIAKKAVEDVIRENNAESRGFLSTEANPRASSDEWMEWVDSDDEEAAISMANHDNIILTASHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAA5</accession>
    <name>A0A8H7UAA5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inorganic phosphate transporter pho88</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAA5"/>
    <dbReference type="OrthoDB" id="18139at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="21411" checksum="6054C25E52D16076" modified="2022-01-19" version="1">MAPPTILTSQVFNIGLMLFSMQVAKRIPWDDPQTVQLARAAYVLAQLAAIGISYYLMLVVKKKNDTTTLRYVKPAKPSTSGQPSEPEMMITTNKAYDLDQLQQAIRSTLTTALMFSVVHFYFKINQPLLIQSIVPIKNALISKEALIHIWGDAAEGPLKRPFKAESPFAALLGMASAPLEESNDTTSAAQKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAG7</accession>
    <name>A0A8H7UAG7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="8">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_001332</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eIF-5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAG7"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0385">Hypusine</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="9">
        <location>
            <begin position="86"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2175685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="158" mass="17269" checksum="96958C9803E1AFB3" modified="2022-01-19" version="1">MSDEQHEHTFEQASAGASLTFPLQCSALRKNGHVVIKGRPCKIVDMSTSKTGKHGHAKVHLVAIDIFTGKQLEDLSPSTHNMDVPNVVRNEYSLINVDDGFLSLMLNDGSTKDDVKLPEGELGDQIQAEFDEGKELLVTVVSAMGEEHALTFKEAPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAH3</accession>
    <name>A0A8H7UAH3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAH3"/>
    <dbReference type="OrthoDB" id="2285020at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2174382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="145" mass="15601" checksum="5A20BCF3A7C69B16" modified="2022-01-19" version="1">MSVEKTSAQALLFVKGDDHIDEGDKSESGGIKLPRIWCKWLFFLGFICPILWVIGSRLPLKEAISDQSFPWKKRCRIAVTIVLTLSIVGSVLALIFNPQAFGLRQNTSSGPQTSSNSNSALRPDVPVNGTSTTGDIVAGMIVAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAU0</accession>
    <name>A0A8H7UAU0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="4">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_000219</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAU0"/>
    <dbReference type="OrthoDB" id="37597at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000013">
        <property type="entry name" value="Proteasome subunit beta type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF3">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2172869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="347" mass="37827" checksum="892156B220B5755C" modified="2022-01-19" version="1">MISPARIVATSPLGSTTTAANFSTSSQQSCVCRVARPFNIAQLTANSTTSSSLTRGFHICTTFFNMNTLVDKYSKSSTASQLDRDVLDVHGKWDASLDLAFPNFDIPGAHNPVSFLRNVTDEASPDYKIKIQHGTTTLAFKFDHGIIVAVDSRATMGNYIGSQTVKKVIEINPYLLGTMAGGAADCSYWERELGRRCRLYELTNKERISVAAASKLLANLVAPYKGMGLSMGTMVTGWDKSGPNLYYVDSDGSRLKGDLFSVGSGSTFAYGVLDSGYRSDLTVEEALELGKRSIYHAAHRDAMSGGSVNLYHIHQDGWTYHGNHDVATLHWEYQESKAKERAASKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAY0</accession>
    <name>A0A8H7UAY0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA-processing protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_005924</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAY0"/>
    <dbReference type="OrthoDB" id="5390at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12932">
        <property type="entry name" value="RRP7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040447">
        <property type="entry name" value="RRM_Rrp7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040446">
        <property type="entry name" value="RRP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17799">
        <property type="entry name" value="RRM_Rrp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12923">
        <property type="entry name" value="RRP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rrp7 RRM-like N-terminal" evidence="4">
        <location>
            <begin position="23"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 7 C-terminal" evidence="3">
        <location>
            <begin position="201"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2174862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="41434" checksum="38367AC7F3110976" modified="2022-01-19" version="1">MAKDKSKAGKSSKPSASSKLQEFSGFKVLPVHMNRGTIHYLYMKKHESRVDSTATPKDRTLFLLNLPTDTTEAHLKKLFKPYARIVNVKYHTRGQQQAGEDDDDDDDEEDTNAEEEEDQIVLTKRQKKMKNAEEAKKKESDPSNKIRQLLTTGSYAHVVVLDTKELDNLLNMGAKRRDWNIEDEATLPLGFDRYRALYSLSHPSSTELQQRVDSFIIKFQAAEYEKERIAAEQQNKMDEDGFIMVTRHHRRGTNTDGTVTVTAAKSDRQVKPQKKKELVNFYRFQMREQKRDQLVELRKKFEVDRKKIEQLKQTLPILPRWYAGHLSKKVRFERFPPYLIQLLARILYDTNIRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UC07</accession>
    <name>A0A8H7UC07_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_008022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UC07"/>
    <dbReference type="OrthoDB" id="507128at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054539">
        <property type="entry name" value="Beta-prop_PDH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22807">
        <property type="entry name" value="TrAA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034244094" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller" evidence="3">
        <location>
            <begin position="79"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2177365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="461" mass="48461" checksum="35640C89A61A86E9" modified="2022-01-19" version="1">MAILSIRKALLLTLAISFVVAQEDTTASDDAAVAAAPPAEEASTLPDATAVGAAPPTKHEKPKNCNPAPVIQPSNPVTAIPGYEAVVLTNIENPRSIAVDDANHFLVLSGADNSIYSLREDACGNVDKQLVLNGSILGAAPLREGLIAFREHLYVTTGDAVVRFKYSPGQHSQLSTQPEIVVRNIGEQGLPITIDPRGNLFIPKGFSQAQNGGTQVRRYDVSKVPQDGYDYENAGAQFTAASANGAGPLAYDTQGKIWGTSIMGDYEQLSLFDITASENTTIALGTKTSDIKFYRGLGCSVGDPETMGTTDGMPCRWTDHAFLAAPNAGIIHIPYSDLAHAPMGAPETLFGQSDLSGCGAGNSCVSPTSMAFDRDGRILSVSTATNEIWIFRRIYNKEAGKLLTDKANAYEAAKEAADEAAEEAAELKKKKAAKGGRGSKGGKGGKGKKIELTEAEAAASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCA4</accession>
    <name>A0A8H7UCA4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PIG-P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_005521</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCA4"/>
    <dbReference type="OrthoDB" id="690928at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052263">
        <property type="entry name" value="GPI_Anchor_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013717">
        <property type="entry name" value="PIG-P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08510">
        <property type="entry name" value="PIG-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="PIG-P" evidence="7">
        <location>
            <begin position="161"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2176287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="323" mass="36619" checksum="6AED491794DD1892" modified="2022-01-19" version="1">MEGETNQPKYASNLPEKQHLLPPDTLLSRKSIAQGILPGSMSTTSLPGLVNYAFGSSSPQTRKDDWYLDSAAAPNRQKSKKQLDRRQSALRRRNSFSNFQAYKTESARTDEDLDFPLDGTYTPPSSTKQSRHRPRSLSEVVSIVTPVEQAPPVATTTKMPTYEYYGFVMYLVSFVVLGIYLIWAYVPDEILHSLGITYYPSRYWALAVPVWIMTLVWFIFISFMSINLMNTAPFDSFTCITDEHANILTSSPNQKEHPEDYIPELHDIPISIVNAMLYQYNDDGAITSNSSEKTSSDEQSFSDHTPDQERSVFNTLHSIDKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCD9</accession>
    <name>A0A8H7UCD9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_004422</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCD9"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF5">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="4">
        <location>
            <begin position="134"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2174399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="39702" checksum="F8503F0D58C17537" modified="2022-01-19" version="1">MAAQKINVGVIGFGMSSKTFHCPLIVSSPHLQLHSIVSSGDKCTQVYPQAQHVKTSDELFASKEVQLVVITTPNELHFKLAKQAMNAGKHVVVEKPFTVTSKEAEELVELSKRTNLVCSIYQNRRWDGDFLTAKKIVEDGQLGRLVEFESHFDRFRNYVKAGWRETDAPGSGMLFDLGAHLIDQALHLFGKPYSVYAVVENQRQLKESNIDDDFTIIFRYKNGPKVLLRSSMLARQAPVLRFSLRGMDGSYVKHHLDPQEDQLKAGQTPLTPGYGIESEERWGTINADVKGLHVVGQVETLPGKYLDFYNNVAETIMKGDLSHLAVKPEQGYETIRMIEVIRQSSDEGGKTIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCF6</accession>
    <name>A0A8H7UCF6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1,4-alpha-glucan-branching enzyme</fullName>
            <ecNumber evidence="4">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glycogen-branching enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_005677</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Glycogen-branching enzyme participates in the glycogen biosynthetic process along with glycogenin and glycogen synthase. Generates alpha-1,6-glucosidic branches from alpha-1,4-linked glucose chains, to increase solubility of the glycogen polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCF6"/>
    <dbReference type="OrthoDB" id="196493at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000001">
        <property type="entry name" value="1,4-alpha-glucan branching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000250">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000003">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="12">
        <location>
            <begin position="189"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2176437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="717" mass="82289" checksum="88429C260E8750B0" modified="2022-01-19" version="1">MLADSNTNSVPTFQSEVEPGRFLTMPKDGTGVAVLDPWLEPFKDALKSRYAMYEKCKKMIQESAGGYDNFTKGYEYFGFHVQNDNSVIYREWAPNAAGASLIGEFNNWDHNANVMQKDKYGTFFVSVPAKPDGSVAIPHNSKVKISLVMPNSGERADRLPAWAKRVVQDLNVNPNYEAVFWNPGHQYVFKNKQPPRPKSLRVYEAHVGISTTEYRVGTYKEFTQNILPRIANLGYNTIQLMAIMEHAYYASFGYQVTSFFASSSRYGNPEDLMELIDTAHGLGITVLLDVVHSHASKNVLDGLNMYDGTDHMYFHGGGKGNHDLWDSRLFNYGAYEPLRFLLSNLRYWMELFQFDGFRFDGVTSILYKHHGMSYGFSGDYREYFNELVDEEGVMYLMLANDMIHQLYPQAITIAEDVSGMPALCRPVAEGGVGFDYRLAMAVPDMWIKMLKEQSDDEWDMADIVHTLSNRRHLENNIVYAESHDQALVGDKTLAFWLMDKEMYDFMSDMTPNTPVIDRGISLHKMIRLITHTLGGEGYLNFEGNEFGHPEWLDFPRVGNNSSFHHARRQWNVVDDGLLRYKYLNEWDRAMQLAESAFGWLSSPQAYVSLKHQDDKVISYERAGLVFIFNFHTTKSFTDYRIGVEAAGEYKVVLNTDSSIFMGHDRIDENGSWFSTPEPWNNRQNYIQVYIPCRTALVLTPKDNLKWSQKDMVVSYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCH6</accession>
    <name>A0A8H7UCH6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCH6"/>
    <dbReference type="OrthoDB" id="2363594at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="143"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="314" mass="36207" checksum="B6FEEED920B2A975" modified="2022-01-19" version="1">MASRRLAKVMSWIREEPGELRRNNSVRYVPPNKPLRRHDSTTTCSSQSVTKASSAVTVKASDFLPSNKHEKLLVMNKQSRMSLYIEDRNGIPMYFGGSSDIGSLSSIPSTTNEKLSNDVQSESLHSLDNSKRTNLGEKVIAPATDVEEENKVLRQQLADQKKLMAQVQRQNEELNELMRDKELEVQKLDALVHSLRRLVPDNKYENTEHIIEHIKFDEVGDQYNTSSQQLQILVDELASEQWKNIKLAEKHDALEAEHQNLVLQHIKNEDIIKEQQSEIASYQDTVYKCEIEKDRMQTRLNNYVWKAQLATKFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCW1</accession>
    <name>A0A8H7UCW1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_008531</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCW1"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF82">
        <property type="entry name" value="THO COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="164"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2180951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="284" mass="30375" checksum="DFC6E327974AA041" modified="2022-01-19" version="1">MSSMDIDLPLEDVIKKSRAQKKSGPKKSPALQKRVQQKNNGPSLGPKKTGKINKSFTTKGPGRVGAPGGQKPKNVVRNPLLNRTGITTAALRAQAIKKPTPPKLDPSSIIITKTVTPKLNTKAEKPRLNRSPPAAQKPVGGGGNQIRGISGNSGFSIRGGSGPTTILIRNLDPGANAEDVRAAFMSFGEVLDCELAVDRSGRSLGEAEVQFASRDSALKAVQQLDGELADGRVLRLSLRDNNAKSERSLFGQSVRSMVSSSVRPESRLYSDNINTTRSSVFDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEH3</accession>
    <name>A0A8H7UEH3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_007602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEH3"/>
    <dbReference type="OrthoDB" id="2344968at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2176948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11355" checksum="7FEDED60362DD9CD" modified="2022-01-19" version="1">MYAKQPHPTIRLLTTHITMKGAKDVRLMLYSVQSEHWPALLGRLQRKFNDENIRALKYLDADGNFSMIADSEDLMVAIESVNPSRGELLCWTLRHGESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEW5</accession>
    <name>A0A8H7UEW5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_006166</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEW5"/>
    <dbReference type="OrthoDB" id="6604018at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="6">
        <location>
            <begin position="35"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2183171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="85" mass="9968" checksum="4480327F8B3CF73B" modified="2022-01-19" version="1" fragment="single">MADKYDEEHIREIQRMRMTLDEETGMQRMKRKFREEPFVPAGVALTCFALVAATVGIKQGRRQYANNMMRLRGECVSNEEASNYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UF17</accession>
    <name>A0A8H7UF17_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UF17"/>
    <dbReference type="OrthoDB" id="347435at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="47763" checksum="740E4CE64D6E08B5" modified="2022-01-19" version="1">MSGSAAQGISSAAAPNAYLREVSSLDQTQLALRHILEHYEGFRKFLLANQKPTQPFHVGFSGCQGSGKTTTCETLATILRQEPYNLSVVVFSLDDLYLTREDQKKLAADNSHNRLLEFRGQFGSHDLDLAQRLFKDLGDAHRQYLESPTSSPAVGIPRYDKSLHQGLGDRLPESQWTKVFAPYDIIIFEGWSLGFKHLSDAALREAYRNSPEASKFTFEEVSKINDNLRLYEESIYPYFDIFCHMAPSSLDNVYQWRLQQEHSMKAARGVDGMSDQQVCAFVDTYMPAYGLFLPNLTKYGFYHESQDQPQSYEGAIRIDGQYSAPLRHLRLILNPRRRVVESSRLDEPDRCVPYTISNWQTKAKSLYSSPSMFRPRGSIKTWSAAAVVLVGVIAFGYRYRREVLLWGSRYRFVGRRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UF37</accession>
    <name>A0A8H7UF37_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UF37"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF148">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2183411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="333" mass="36318" checksum="142BADCEBDBA89A9" modified="2022-01-19" version="1">MPASKTLVHAVNAEPEGYRYTTEQVLSSLPGGVSVSNKVFIVTGSHSGLGEETARALSAHGAHVIVATRSETSGHAAIDRIKKGNPQAKLQWMHLDLSDLDSVQEFVKEFHKTSLPLHVLICNAGIMAHPYAKTKQGFESQFGTNHIGHFLLIKLLMDDLIKSGPGSRVIVVSSRGHRWAGVRYDDPGFEDGKAYDPWKAYGQSKTANILCARTFNEKFGDKGVEFFSLHPGVCSTNLASGMSEDVKKEMLSMMPPGSESMFTNDPPKWMKTIEQCAATQVWGATSPELNGKGGAYLDDCHIGKPLTEEAEDVTGENGRRLYDMSMKAVSNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UF47</accession>
    <name>A0A8H7UF47_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_006447</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UF47"/>
    <dbReference type="OrthoDB" id="414133at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050750">
        <property type="entry name" value="C5-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46098">
        <property type="entry name" value="TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46098:SF1">
        <property type="entry name" value="TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2183441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="42206" checksum="0587BF20071C7960" modified="2022-01-19" version="1">MITCLEFFSGIGGLHHALNVAGVDAVVLKAFDMNEVANKVYNRTFGSAPSNKAIDRLTVKEIEKYKVDCWLLSPPCQPYTRGGNMKDSEDQRAKPLLHLISLLAKLSNAPQYLFLENVKNFECSQSREVLVKELDRLNYDITECLLSPLQFGVPNHRLRYYLCAHKRAHDKPSQDYIETATIHEKWPFNGDSATFAIPPISQFLDLDEPAIDQHLVPAKYITKSHNFRFDITLPSHSQTSCFTKAYGSHHVQTSGSMLQTRNLELLLQNNYYDWANPESLLDLGLRFFTPTEVARLHAFPMAPWANEFSASETDNDSKLPRQYQPPHCTPHIDFPQEITTIQRHRLLGNSLNCWVVAELYRCVLFNPAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFC8</accession>
    <name>A0A8H7UFC8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_006707</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFC8"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 11-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="519"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="594"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="605"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2183696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="664" mass="73407" checksum="DE7FD688711C8022" modified="2022-01-19" version="1">MLMASIQGDQFIRTLAHYLRSNEHKLAAPRQPPKETFTGVGVTTANVQKSALSSTMGAVTSLFGTTQAPTPRRPAGNISTGDSPPASIYGVPTSYLPFYPTSRPQSPSNSSTLTLDPHHLYFLLVQFEHIGLDIGDPALLGTIPEDGIVETETSATENKAPSIMSMASNISTLSLSTGWNLWERRSKHQESKFSIEDEITYIYKVLSHISSLKLHLNLSVHSQSGATRSGSRIIKGYETPLPQDGKSLRISATPFRSLTHLELVNVHPRMIDGWIGLQDQLTTLIIKGARVEDINEVIVEEIAASLQKRGQFVPHEEDEENLDLEKLLGDQPWSKLKHLSLADNSIPSLDNAPLHYIQSLEHFDLSSNLLIDIPNSLTSLYNLRSLNLAHNMVSSVTGVNAILGNVQELDLRGNRLTILAGLDRLWSLERLDIRNNRLEETGEVGRLASLPGLKEVWVEGNPFTAHEQNYRVVLFNQFKAANDTDVLLDGSGPSAIERRHVIESANDNGQIPAAIVATASRAKQPPTPSASSPKQGTSMDQPKKEKTSHGKQKKHKRIVRLDSEQQIPLDSEDSSDISAEDSKTQETNNRRVLRYAELEADARSRSRSPKPHNTSGKRKPRKAPVPMENPVAGDDYRKKIEAMRNEAGSGWLRVLNEMEDSNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFW6</accession>
    <name>A0A8H7UFW6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_003036</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFW6"/>
    <dbReference type="OrthoDB" id="5788137at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF35">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="75"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2177789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="201" mass="23321" checksum="D3CA5627C4103957" modified="2022-01-19" version="1">MRELSPSTQLAYSKFALHQDATQTFAGRRLVEITWSQFSQLTMILQEVFYVHRYSGSISLSSAALISSSYAIFTVVTYWFSTYVAPEEYSQPQCRTGIALFVFGEGVNLYHHFILSNLRTTGPNQYKLPQGGLFRYIWCPHYLGEIISFMGIALISQHLYVALLQVSSSLYLCTRAYNTKKWYKEKFGSHHERWCVFPWIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGC1</accession>
    <name>A0A8H7UGC1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGC1"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="482"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="570"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="808" mass="91616" checksum="E51A4F758C9DC9FF" modified="2022-01-19" version="1">MGGSGQRSSNMTSTQQHSECECDEAMTCRACNKKPNAKAQAKAKKAQHDDLEALQITFYEIESWIEKTTPVLNRMTKELEKASVHFDKKKKERHQENGISSGSSTSQPPSKSASDEQQRRVQWTFSFEPQGSMSLETNITSIDQLVDAVQKIKLLAKPEDLQDQENQQNALDSQDDQDKDIGDRQGDVDPTLEFWSTALYRRPEPHFFDKGVNETARQVADQVSPQILQYICQVYWDCLHPKFSADWTTFWHRSDDPKRNQLCVESALAIVFLHVVRHNKTICPNAPDIARVYFERARELLTDCFDTPDCSTIEALMNLAMFLVLCKKHSQARLYMGLGIRIMLELGINKRNNLPVDRVLRKRYIKAFLVVYYNDLILAAYMVDQAQIDDKACDIDFYEMITLNEQLMEHGEAKFDDKTIAKETFFVHLLELAKIGKKAQALTEERAQNKSEPNSRWIKKIAVLESSLHLWYQRLPEYLRVDPSPSSSSSSSNSSVSSNQSYRMRRQQQQPYLSPGLTPSPPDTASPLDLTQCMDAQQLKDQSALLLMLQYQTQWILLHKSFLPASLSRSPTTSPAADAMPRNNFKFSSSSNGNNNNSANRYANLPHAICTDAANRIVVIADLITQQYGWCVFQQFVNCLYQAATIHCRNTLSRDEGIQRNARAMIKRILKILGNGSIHYQGLPADLTVCLQEFLTLHGMHMDVDGQDTYGLESGDVGDLWGEDASSEMPPTGIATPNAPRSQELLQKSLLADDGLDTLMMEYHVDGLPVKMEPDDVFKADMSEQQIKNWRCKFSSTNIAHLTHRSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKY3</accession>
    <name>A0A8H7UKY3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKY3"/>
    <dbReference type="OrthoDB" id="191037at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="378" mass="42120" checksum="3FC51AA11B74B6C1" modified="2022-01-19" version="1">MSSKSSNQASQGTSEVREGHQIDVQTLETYLSEKIPGFKAPLAVSQFKFGQSNPTYLLADANKQQYVLRKKPPGALLSATAHAVEREFRVLNALGTSSDVPVPKVYVLCEDVSIIGTPFYVMEFVKGRIFTDVRMLSLPFEERKQCWYSAIRTLAKLHKVDYVSAGLKTYGRNGGFYSRQIKSLQKVSAAQAAVVDEESGKPVGNLPRLQEMLAWFARNQVSDRSTIVHGDYKIFHPSEPRVIGILDWELSTIGHPLSDLANLLQPFYLPGDGDDANPGFRSVKVEDLPIPPAERLMQIYCEESGISYPIQNWSFCVAFAFFRVAVITQGIAARVARKQASSPQAKWYAARFVPFTHLALEIVDQGELDHVSEDKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7ULT8</accession>
    <name>A0A8H7ULT8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_000402</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7ULT8"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057600">
        <property type="entry name" value="TORTIFOLIA1/SINE1-2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24714">
        <property type="entry name" value="TOR1L1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="27"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="165"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="386"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="427"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2184493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1049" mass="116710" checksum="16E15418809043EA" modified="2022-01-19" version="1">MDQYIAGLDETLTKLALGQDSETIRVATSNLNTQFYNTSQCVPALVEIITKSPHVQVRQLACVELRKRISKWWMEQDEATSAAIRAKLLEIVLHEQQNLVLHAAARVISAVARIDIPEGKWQDLLQFLYQCCNSPNAAHREVGIYCLYTLFETVSEVFLEHLANLFELFAKSLNDPESKTVRVTTVQALGKVAEFIEPDNKEEIRMFREMVPGMVKVLEQCLAESDEENAGKGFEVFDTLLMLDTPLLSNHLAQLVEFFLNVGGNRDVDDSLRVMALSFLMWAAVYKQNKLRSLKLVGPMIERIMPIGSEEDPEDIDEDSPSRLAFKVLNSLATNMPPTQVFPIVLQNVVNYMQNSDPSYRKASMMAFAVVIEGCADYMRPQFNDLLTIVCAGLQDPEIVVRRAACMALGCLAEELDQEVAENHSTLLPLVFNLMNDTNPEVTKHACNALDAILEGLGDDVVQYLPMLMEKLLQLLDNAPQIETKATVTAAIGSAAHAAGESFQPYFPQVMPRLRHLMTLKTNSDEQLLRGVATDSAGAVAEAVGAPMFAPYLQDVMQLAIEGMQLDSSRLRECSYCFYSIIARVFKDDFAVYLPTIMPNIIASCQAEEKDDFNLEGEIDLTTSDFDDDDEGLNPFSFNSAIADEKEIAADAIGELFENTRSHFLPYIEPTVNELVQLSAHISEGVRKAVTNSFFTFLQTFYAMSNPSQWVPGLPLKYTVNENVDSMIKLVLPATLRMWDDEDDKMVVVQICQELVETIKMVGPAVIAEHVDPICQHLLEIFEKRALCQQEDEDEDGLIDEDEQAEYESMLVGSASDLVGALAQAIGEGFAQYFNVFLPHISKFYKDKKTGAERSMAIGCLGEVIGGIKSGVTPHTEQLFTLFLKAAADKEEEVRSNAAYALGVLSAYSQVDVSSQYNNILAALYPLFQGQTLPNVTDNAAGAVARLILAHPEAVPLDQVLPTFTTALPLKRDFEENEPVFECLFSLFRANNSFVMAHIPQFLHIFAQVLGEEGQIKDHTKSQLIELIRALDAQSPNLNIRSSELAQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UN99</accession>
    <name>A0A8H7UN99_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UN99"/>
    <dbReference type="OrthoDB" id="73788at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF5">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="2">
        <location>
            <begin position="272"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2186023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="417" mass="47132" checksum="DAA4C605C405BB0B" modified="2022-01-19" version="1">MDDLYQFTADAVNQNKGGKDAEKQRQQQEQDDIVLKAFNSFGFSKKWDSLLDTVKKQGGAIVDVTRRDLQEFANVLKDDIVQAGDITNRETGEAKDAEREDKTNNESESSKSFDIFESSAAGFASLRESLGKLNTVNLDRMKEGLQHTLSNIPTSMESVHLPGNINIQQLRDELAAGSKFAEQYLEKFGTDAVQTLSRAITVVAPEDSEYADSEFGTSSATENQSSSKRIYWNIYSTSRKEAMVAELRTDKSYFMMPPTQEDEDVKKIYETFVAGFSVEEYTDEIAKLLQEYPDLRQTMDELVPVQVSYHDFWLRYFYRSWKIDQEDEKRRQIVQGADAQDDDDDADFKWDSDDDETPMQQEDQSTEVAANISTLPAHTAGVPSDTEFSNISASSTTEASLVSAPKEDEEDDDSDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UP59</accession>
    <name>A0A8H7UP59_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UP59"/>
    <dbReference type="OrthoDB" id="274641at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2185949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="132" mass="15245" checksum="4C12292D63026B46" modified="2022-01-19" version="1">MSTLGRTFKNFMRAGPASTWRQLQFIGDTKYGALIGTDAVGNKYFENNDEIYGRERWVEYASNDPDPAQITPEWHMWINKFVQEPPTEMNLKPTKFEGAPTPNFTGTKNAYVPYNTVRPKYSAWEPQVKSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD12</accession>
    <name>A0A8H7PD12_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">chitin synthase</fullName>
            <ecNumber evidence="5">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">INT43_008039</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="28">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="5"/>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14879">
        <property type="entry name" value="MYSc_Myo17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000017">
        <property type="entry name" value="probable 18S rRNA (Guanine-N(7))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036037">
        <property type="entry name" value="MYSc_Myo17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF45">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="20 22" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="14 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="17 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18 22" id="KW-0505">Motor protein</keyword>
    <keyword evidence="16 22" id="KW-0518">Myosin</keyword>
    <keyword evidence="13 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1174"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1209"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1483"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1872"/>
            <end position="1895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1907"/>
            <end position="1926"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1933"/>
            <end position="1956"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="26">
        <location>
            <begin position="294"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="25">
        <location>
            <begin position="1237"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="27">
        <location>
            <begin position="2151"/>
            <end position="2206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="22">
        <location>
            <begin position="909"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1027"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1027"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="395"/>
            <end position="402"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KAG2171659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="2208" mass="248257" checksum="F3A49CC47BFAB1CC" modified="2022-01-19" version="1">MSRPEHIAPPEIFYGETEATKYTENSRIAAIQAEMAYRALELLNLPEDEPAYLLDIGCGSGLSGEILQDEGHIWVGMDIAPFMLEVAKERDVEGDLFLQDAGQGMAFRPGTFDGAISVSVLQWLCNADKQINNPKARIARFFSTLYSSLRRGARAVFQFYPENDDQIQMLTDTASKCGFEGGLLIDYPNSKKAKKYYLCLFAGQAEGVKNKMPQALGEDGSEHPAVASVEFEKRRIKERRRSDKRRPVKDKKWVLHKKETMRSRGDRAVVADSKYTALAMPRGKNSGNLGANALQNTDLSKLESSSEEDLTTVLKSRYEQDHIYTRIGDQVLVSVNPNKSLSLCSDAHSLDYVAEYKDISGQNTGQLSPHIFQLVNQTYLHMRRTGVDQSIIVSGDSGSGKTDAHNLALRHLVGLSSHKKPSKVQTQLLHSQTILEAFGNAKTVQNHNASRFGRYTEVQFSERGRVMGAKILNYFLEKRRVTEAHADERNFHAFYYLLAGATAEEKSELRLNDHSGFSYMSRCRSQATAEDATKYEQLKASLKTLGFQKKHVARMMQLLAAILHLGNITFIDDPSKGQEAATVKNVEVLSLAADFLGVDPHGLELVLTYKTKLIKKDVTTVFLNAEQACAQRDELAIALYSLMFTWIVEQMNVKMCNDGFHSFIGIVDLPGPQNNYAPAKFEHYCVNYANEKIHDFTLRQLFEQDQAAYQDDGIKIPDVPFFSNAACVQLFDKPVNGLNTILTECTAKAQRRTDDNMLDSFVKYNNNHDSFSTRNSETGSRQFAIQHFAGQVSYDPYGFIEGNNDPLSADFVNLFRGNADTSGSYNSFAFNLFSQQAVATQSHPKSSDDIVAAQQTAKPVRAPSMRRSKSLKKAGISDKKDQADFVKVKSDSKGSNATVGVIAQLQSSLEELMATLEETTPWFIFCLSPNSSGSVNMFDSKRVRAQVRAYGIPEIAKRMAINYTMVLTHQEFIERYSDILHSMGVEEDRLPRSKCEAVATMFGWSSSQMSVGTNNVYLSEQPWRNLEDGLRGQDKEEQRRAKEERKKDDGMQDFNSIGMRRQESADRLSNHSYGSGSGLIPAAATGAFAGAAAGGLLRPYEEKSGYSEDQRSFYSEDEFMQDEHYRENESTFGSEAFGSSHGIDQEIKTMLPPQGDTVDVDETESKPTPGRRRWLWFVMFLTWWVPKPFMVYCGRMKRKDIRVAWREKFALCIIIFFMSAFIIWFLVFFGELVCPHQDVYSQSELQAHNNKENAYVSVRGEVFDLTSFAPHHWAIDVIPEDSILTNYMGKDATSLFPVQVSALCQGTTGSVSPFVSLDYQINLTDKNAQYHDFRYFTNDYRPDWYFESMTNLRKLYKVGSMAFDSNTVYQQATTSTVLNGISTYRQWAILNNNVYDLTYYIMGGRYLKGPNNETAPAGTSTDFLDNSVVELFRQQAGSDITSNWNKLPMDTATRDRMEVCLRNLFQVGVVDTRNSAKCQFSTYLLLIVTILLCSVIVFKFIAALQLGSKREPEEYDKFIICQVPCYTESEESLKKTIDSIAVLKYDDKRKLLFIICDGMLIGSGNDRPTPRIVLDILGVDPNVDPEPLSFFSLGEGHKQHNMGKVYSGLYEIAGHVVPYIVVAKVGKPSERQKPGNRGKRDSQMILMRFLNKVHFDSPMAPMELEIYHQIKNVIGVNPSFYEFILMVDADTEVLADALNRMVSCFVHDAKVIGLCGETTLANEKDSWVTMIQVYEYYISHHLTKAFESLFGSVTCLPGCFSMYRIRSTLKNQPLLVSNQVIGDYEVNVVDTLHKKNLLHLGEDRYLTTLILKHFPNYKTKFTPDATCKTNAPDTWSILLSQRRRWINSTVHNLGELVFLPQLCGFCCFSMRFVVFLDLISTLIMPATVGYLVYLIYKLATSPDGVPIWSIVTIVAVYGLQAIIFIINRKWEHIGWMIVSLLAIPVFSLYIPVYSFWHFDDFSWGNTRIVVGESGKRVLVPEDQGKFDKKSIPTMTWTQYEEGLFQEEEQFNDVASVGTHRTGYTQGSYRSHPSHHMAAPSAYGDNASAFDDYNYGGGNRSRSRSPAPMVPFNDASSYHMSLGGGGMGANTRMSSAYSDMMSQRGPMFGSQTEFSNYAMSRPGSAMMPASSSIMDYHSGMSPGSGSVQGDILPSNETIMNEVRNILANADLMSITKKQVRDRLSETFGVSMSGKKEYINSCIETILQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDB7</accession>
    <name>A0A8H7PDB7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_008205</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDB7"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000720">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000181">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF369">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="152"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="202"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="271"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2171825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="322" mass="37447" checksum="EA70B6961B691D35" modified="2022-01-19" version="1">MGVCLSAEERENRQRSHDIDKQLEEDNKRLMQEVKLLLLGSGESGKSTIVKQMKIIHQDGYSTDELLSWRLCVFKNLIESAKDLVKAIGIVDVQFQIPYNEQHAQVIKEYLMPTDPKMTFSPEIITSIESVWHDPVIQTVMDRGGSEFYIMDSAPYFLAEIRRLTMPEYIPTVADVLRARLKSTGILETRFNMGKLNIHMFDVGGQRSERKKWIHCFESVTSIIFCVALSEYDQVLLEESKQNRMLESLILFESVINSRWFVRSSIILFLNKVDLFKIKLAKVPLERYFPDYTGGNDITKGARYILWRFNQANRMKLTIYPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDJ0</accession>
    <name>A0A8H7PDJ0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_009052</name>
        <name evidence="15" type="ORF">INT43_009116</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDJ0"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000008">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="13"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="13">
        <location>
            <begin position="93"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2171391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2171455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="131" mass="13911" checksum="AEACAF25C85BF39A" modified="2022-01-19" version="1">MSGGKSGGKSASGSKSQTRSAKAGLQFPVGRIHRLLRRGNYAQRVGAGAPVYLAAVLEYLAAEILELAGNAARDNKKSRIIPRHLQLAIRNDEELNKLLGHVTIAQGGVLPNIHANLLPKKSKKVGASQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDT7</accession>
    <name>A0A8H7PDT7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP11-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_001544</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDT7"/>
    <dbReference type="OrthoDB" id="16535at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010591">
        <property type="entry name" value="ATP11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126:SF0">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126">
        <property type="entry name" value="CHAPERONE ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06644">
        <property type="entry name" value="ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="81"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2172067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="36298" checksum="8398844B6F06368C" modified="2022-01-19" version="1">MLARRCFETLRSTSKNVASPVRQQIRQAEVVSGFSPLIFSQNATTSIRRMATEAAKTKIDYDSKYAAKLREAAEKKGTKSVEELKQKMKTESDRIRIERNKAAEKAAKESAERHKAAEAAAAAEVTAAKRSPSQVAAVAKNPYDSSAPTLDKIVKIELLEKESPESIHKIWTEYHADKECITASIPAAVYGTLYQTSLKYPMFILPVPRDEGVEFFLLQFNYHQVQFTSLLEYKTKGEEARPYLTISHFPELIKTKDIVLMKGEISDTKLLSVPNAQYLAFALQQFYVTGGDKKKQLLETFHSKPQEFDYNEVIKEMENIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PE19</accession>
    <name>A0A8H7PE19_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_004740</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PE19"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="67"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="555"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="561"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2172199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="585" mass="62430" checksum="A29F58E31FA9A590" modified="2022-01-19" version="1">MSTDNRELNESTVASNDFTVAGSNYDEEKIIDSENVLVAPINEAVAATPEAPAEAPPRPTGIKFALIFVGLMLAVLLAALDQTIVATALPTISSDFNAADQIGWVGIAYMLTSTVAMPLYGRFADIFGRKPIFLFAIVIFLAGSIVSGAAQSMNMLIAFRAVQGLGAGGIMSMVMIIIADLVPIRDRGKYQGLIGASFGIASVVGPLLGGAFSDHASWRWCFYINVPIGAITLAVVILFLHLPKPSGSIKDKLKMIDYLGSLVLIGCVVCILLPLQGGGNQYAWNSPVVIALFCVGGVLLIAFILVEKYIAKSPIIPGYLFRQRTPVALFISQFFFGLCFFGGAIYYTPIYFQVVRGDSATSSGLELLPLMLGLVFCSIGSGLMVSKTGRCREFIWVGTSLCIIGGGLLTTLDASSNRGEQIGYLLIMGCGCGLCVQTLTIAAQSAVGPKDIAVITSLGNFFRTIGACFGIASFGTMFNNTLATQLSKLTLNFPIEVAEHSFEFVKALPEPLKSSVINAYCVALDRMFLLIIPFAAVAFLSSLFVQHFKLRRGPPAPPAQKAEEKPAEVIDEKTPQVSKETVETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PE97</accession>
    <name>A0A8H7PE97_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PE97"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047974">
        <property type="term" value="F:guanosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF161">
        <property type="entry name" value="CMP_DCMP-TYPE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="164" mass="18250" checksum="503EEE892A14C8FA" modified="2022-01-19" version="1">MNSNYTEPSHEDIIKYLKLTIKVAARSITLGHHPFGAIVVGPEGNVLAEQGNIDTLNHAESTICRIVYTNYPQEYLNRCTLYTSFEPCAMCSGSCYWAGIGGVVYGATEERLLALTGNSDENPTMSLPCRQVFDAGQRKVKVFGPFPELEEEIVADHLQFWKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEG8</accession>
    <name>A0A8H7PEG8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEG8"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035145">
        <property type="entry name" value="DUF5482"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17579">
        <property type="entry name" value="DUF5482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2172439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="170" mass="19156" checksum="8A8C154BA605D552" modified="2022-01-19" version="1">MIYNEIDKKLISLGDSKQVFGKSKHLTPVYYSGGSLEFTERNRYVRINGIETTQYNKKQVIVKSKLIAKMVEDIVSAINEDITKKINSPILTDGSVRLNVTKDTRFTNSKRNAIKDNIDNSLFSACVSISVPTIFTDTDKSTIQLVLSECVIIEIKESLEIDFNELKVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PER6</accession>
    <name>A0A8H7PER6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">INT43_004851</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. Component of RNA polymerases IV and V which mediate short-interfering RNAs (siRNA) accumulation and subsequent RNA-directed DNA methylation-dependent (RdDM) transcriptional gene silencing (TGS) of endogenous repeated sequences, including transposable elements. Required for RNA silencing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the RNA polymerase II, IV and V complexes. Interacts with NRPD1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 15">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PER6"/>
    <dbReference type="OrthoDB" id="282270at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000419">
        <property type="term" value="C:RNA polymerase V complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10508">
        <property type="entry name" value="Zn-ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034012">
        <property type="entry name" value="Zn_ribbon_RPB9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 12 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="16">
        <location>
            <begin position="71"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2172309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="114" mass="13188" checksum="F1281E7FE4E9F0A4" modified="2022-01-19" version="1">MASFKYCSECNNMLYPREDKTNRKLLFACRNCHFEEDADNNCVYRHEIVHAPSEQTMVLTDLSADPTLPRTTTACPRCGYQEAVFFQSAARRADTKMTLFYVCCNRGCGHRWVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PF96</accession>
    <name>A0A8H7PF96_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_000222</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PF96"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000618">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="76"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="389"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2172872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="606" mass="67922" checksum="AFE70E09C7602FC8" modified="2022-01-19" version="1">MSAVSASKQKRMAARQARADKKAGKEGSPMSTDGTNTPITPASNASLSDLPIDKLNLKVDRTATGVYTSQERSRDIKIESYSLNYHGRVLIDNANIELNYGRRYGLIGANGSGKSTFLHSLAERDIEIPDHIDIYLLNQEAEPEEKNAVQAVIEMAEAEVARLEKKVEEMLTEDDGADNPLLEDMYERIESLDPATFETRACTLLSGLGFTTQQMAKHTKDMSGGWRMRVALARALFIRPTVLLLDEPTNHLDLEACVWLEEYLKTYDRILVMVSHSQDFLNGVCTNTMDLTHKRKLIYYGGNYDTFVKTKEENEVNQAKAYQKQQDEIAHIKKFIASAGTYANLVRQAKSKQKIIDKMEAAGLIEKVEHPPPFKFDFTDVERLPPPVCSLQEVSFAYNGQMKDCLYRDIELGVDMDSRVALVGPNGVGKSTLLKLMGGELNPTAGRVQHHSSLKLGKYSQHSNDQLDMDLSPIDYMKRKFPSVSTQTDFWRSQIGRYGLTGAHQTSPIAHLSDGLKSRLVFAELAMAHPHIILLDEPTNHLDMESIDSLANAINKFNGGVVLVSHDFRLISQVAKQIWRCEDGKVHPFEGSIQQYKESLRKNVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFU2</accession>
    <name>A0A8H7PFU2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFU2"/>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="87"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2173171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="403" mass="45639" checksum="23EE06342A0CCD6C" modified="2022-01-19" version="1">MEGIRKALRKMPPSTTIKVLRKVFAMPAPAARLILNDVTRARKEHKPWIKKVTWNLEWKGCWIGEDVQNLDEGAIRQRIDEADVVFFNVHGGGFRLGTPTMYMDAYIAWIKTLKLKYGLNAIMMSADYRLAPEHRYPSPVEDIVRAYEYLTRHLNVEPYKIITIGDSAGAALILEMLFITHDPSMFEIVTEDTDDDNSTQPVLEELPRPAGSVMISPLVTDETTSESWKENVKYDYVSQYTAKVIKKDYFEPLDPDTPPDAIRVLGIAKLTTGFTAFLPKHCLFYVGDKEVLRDDALDVANKARDDGVDVETVMEDCVHDWFCVREVVKDKKVLERADDKLADFIELSVREAREEHEIAMKNAAYDPGLESVLEVDEDIPEISLEAKENDSGANGQHNMALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGF9</accession>
    <name>A0A8H7PGF9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein FAM72A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGF9"/>
    <dbReference type="OrthoDB" id="2526683at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026768">
        <property type="entry name" value="YPEH2ZP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31841">
        <property type="entry name" value="PROTEIN FAM72A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31841:SF1">
        <property type="entry name" value="PROTEIN FAM72A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14976">
        <property type="entry name" value="YPEH2ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2172861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="34655" checksum="B58A43410ED2AB2E" modified="2022-01-19" version="1">MTGYRAGQRQPQAMYHLSEESLQSFYAARDRHTSYQNAAAAAIAAATQYHQQHGQQHAEHYEGQYSQAMRRRVQPTHIGSRIPQPSLSSPSTSSDSSSSSSSGATLMEHPPSGMRLTSGGASGHYQQHVSRASAPNSLYTSQPPPQQQQQQQQRHTLHQQPPRDFANAYPMKPVYKLSCKHCCNVICARGMKAILLADTSIELYSTDTPPRGSIQLMDKDYLTRTCRCRIRDIACLGCGNIAGYHVVSPCFQCLEACNNGHFWMFHSEFCQPAERTDVSGKQTLLWSSLPRAEMDVDFVFGNTIQHEAVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGS9</accession>
    <name>A0A8H7PGS9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_005122</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGS9"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000032">
        <property type="entry name" value="Krueppel-like factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="244"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="434"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2173702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="488" mass="55469" checksum="3653F8CAC23A577B" modified="2022-01-19" version="1">MSMYDDQNNELMDHKLPSISLLPQLDNQDDYASKNESKAATLSHTSPQECLKPSMSTSSNNSESSQGHAIPTPSSFLPPPYIPKDQNQNINCSYSNVVSPPLTPAVSPSSMLYDAMQMKRKYSVDVGPFAFSSSMVNHASVAASAFNTDMYQEAYRRHSMCSEMSLDDYTHHNAHSFAMPAPSPQPMGESSRGRRESTSGRANSKPIQSSAHKHVCKYPYCGWSFKRYEHLKRHMLVHTGERPHLCDFPGCGKSFSRSDNFAAHYRTHTKKTLLQHRNSVPNIETMHQSNAFFRQNKMPPNFDFARPYELYNDRQGFPSEQMQTTPEMIQHQQYLRSFETLQAIDTNQNTFQTTPLAKMDYMHMHQPSSPSSPTAPSALSSSLQNPISDVYIPMNVMSTPHQQKVHACQECRKRFKRLEHLKRHMRTHTLERPFSCPVPGCGKAFSRSDNLSQHVKTHQRHQYRERNAAAQVAAVNNNVWENSTTVDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGV5</accession>
    <name>A0A8H7PGV5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_005026</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGV5"/>
    <dbReference type="OrthoDB" id="2152896at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2173608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="318" mass="34545" checksum="1D1706CB56470C6F" modified="2022-01-19" version="1">MASSLTFQLRQQQKEESNTAAALSSSASSTSLPSPPSSSCGDDSSSTSPDPSTHDTQKPVKRAVLAQSIPAQSFMRRDSLGTQLSGLSLMEQKQHQPAASLPENYTIDHSAPIPIIHPGTPINSAASSVSTSLRRPSLSSPRDILATSPAGRPRRPSEASRKLRVSSLSESAGRKLSVGSLSALSESVGRKNVYRCEECGKPYKHANCLYKHRWEHSEQWAMTSKLNITKHQQVQLLEAAAILVNMDSTRRDSHGALLLPPNMKSEEDDIDEELEIGDGDIQGNGQSKESRESTLSLDTEEDEEATEDDEDMMMMEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGW0</accession>
    <name>A0A8H7PGW0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_005108</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGW0"/>
    <dbReference type="OrthoDB" id="7813104at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000001">
        <property type="entry name" value="mitochondrial import inner membrane translocase subunit TIM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="13">
        <location>
            <begin position="24"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2173688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="100" mass="11155" checksum="080896D8D59AA8C7" modified="2022-01-19" version="1">MSDYANYNLGGGDLSSKKQEVMEQVRGELALANAQELINKINEKCYLKCVPKPGSRLDSGEQACLSKCMDRYMEAWNVISRSYVARIQRESQNQGMSGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PH03</accession>
    <name>A0A8H7PH03_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="5">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">INT43_005236</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="5"/>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PH03"/>
    <dbReference type="OrthoDB" id="448573at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000022">
        <property type="entry name" value="CDP-diacylglycerol--serine O-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF61">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG2173816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="246" mass="26864" checksum="67A2018D5958B784" modified="2022-01-19" version="1">MSSRSKAPKSGKSVNSAAKHLSESDAKLISNDVGHFSMVRNFALADVITLMNGMCGTMSIFSSMRYLVSNDRCDLHTAMWFMPFGLLFDFLDGRVARWRNNSSLLGQELDSLADLISFGLAPAALAFAVGMRTRLDAFGLTYFVCCGLARLARFNATVALFPKDATGKVSHFEGLPIPSSLAIVGFLAYSINGLNLSNTDKFPLSILQLPMPMGINAKYGEIHHFTLLFVMHGTAMISRTLRIPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHL8</accession>
    <name>A0A8H7PHL8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thiamine pyrophosphokinase</fullName>
            <ecNumber evidence="7">2.7.6.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_004151</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>thiamine + ATP = thiamine diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11576"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the thiamine pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.2" evidence="7"/>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHL8"/>
    <dbReference type="OrthoDB" id="25149at2759"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016966">
        <property type="entry name" value="Thiamin_pyrophosphokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031057">
        <property type="entry name" value="Thiamin_pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="8">
        <location>
            <begin position="182"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2174131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="277" mass="31123" checksum="7CB87B7C81FE43D9" modified="2022-01-19" version="1">MTDNSTMRRWRPSAVLSLTESLKRPHALIILNQKINRVDILKKVWAAATYRFCADGGANRLYDMFMDDAESRAKFLPNAIHGDLDSLRADVREYYNSKGVSVTQDHDQYSTDFMKCISLLRKTEAESASKEAKSGNTPKKVGCGRFDQTIASINQLYFMKDETDRQLLLVSDENLTILLDEGKHIIECNREVEGMYLSLYGQIMPVILICLVGPTCGVMPLGGPVRLTTRGLKWNLTDYPCHFGGMVSTSNLLDSDTIEIETDKAVVWTVELKEGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJC3</accession>
    <name>A0A8H7PJC3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_006033</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat WDR59 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="311712at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049567">
        <property type="entry name" value="WDR59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049566">
        <property type="entry name" value="WDR59_RTC1-like_RING_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17120">
        <property type="entry name" value="zf-RING_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="181"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="295"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="RWD" evidence="6">
        <location>
            <begin position="560"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="689"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="790"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="695"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="792"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2174971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1484" mass="165426" checksum="6392CDC2EF6F5F29" modified="2022-01-19" version="1">MQQQSQDPEALLASSFQQHSSKTANRDDFTESQRNGQNTTLSVVENLPGTAPQGSLTGRRKRQRSPTTSSQTTGENTFHQKMQIRVRHSVGSMSISPSSRDIVLAGLLIQCQHSRQGLLIIDLENPWLPPRILPHMSKWEVADVQWSPYLARESWIASTSNQKALIWNLNYSGPKAIEHILHAHSRAISDINWSLHDPNMLATCSVDTYVHMWDVRIIGQEAHSGSEGIAIGSRDIRPESSFCAWTAGATQVKFNRKNQYLLASAHDKNVNIWDIRLTVDYLIRQQKGSVPVTTINAHSTKIYGIDWSRQNGTDIVTCGLDKTVKFWDINDPDTAQTTITTNSPVWRARNTPFGSGVLMMPQRTETTLFLYNRNTPKEPVYAFEGHADNVKEFVWRWRGDPDHADKREFQLVTWSKDQNLRLWPITKELMGLVGDKDGDSQTHPTISSQTMELDGTYRPHSFQRPPAQDLESGLKSPGAALMRVMGSNRTSTGFSPLKPAIPGTSGIDTTTGREGVRDIYRDQKYAIPPLLWMQNVKTVRPTGELHKDGATEDTFQNVAEEMSIILNKFSSAGVRTERVNAASRTCTITLHGPWSDTGSAFLRITINFPPQYPDNTPPEFEIQKNSMISIFYRAHMAQDLNTLASAYTAQKRYCLEPCLRYLLGEAPAEELTHLRFGVGNAHGFSPFAPKGPNGSAGTTNDASGFGNWNTSPGVNNADSDDEMYVGSSFASDFGFQGKRVSMQSEKGIIVDMSVKQSADQNVPFPRLCGATFSGNGTLVTFFSTLRVRNSERSSTTAEKSKSSTNLTSGNNNNSFITNNYSEFYHHPKTYEQFEEYKEIAAMSRQGRNATVLASGNSGAFGDYTYDDGEDDMDEGVVHNTASSLYLRPENLEMGNSLNNDESILYPSAKAHHETYHVTLHNLGDVLPFNANLARAYILSGEDPLAICSHNAMACKALGYLELHKVWCLAGEILRECVPIANTSYKDYINNMPGRARSTDVTQNQMHKYAHDLKLNSLVTPLKHPWERRDSGTGLPSNDISVVQRRHMERITWGVHPLGRQLVDKLMLHFVNKGDVQTLAMLSCVFKEPFYNEKVSSDIVPALTQPDTPQITPMPASSSSADYFSFRNRQESLRSGMFTAVTPYQGSRSNRASESYHSERDFLAQLPFAVDPTPTPFGLGITHNNGATDSYVAALDAAKHSSSFKLSVPQRLPTNTAPTVRNNTDDGFLSMLPFISYSWGSTTTAIPVTPETPRGHPPMLNSSVNVGRDGHVAPQEITIKMTNTEAFDDDRLFQHQIPLLDPSKLNEMNAFRIFYADMLYRLGLFEKRAEVLKFVVQDFTQGDKLNGNSSQVNNHLHALLGTNDSPQLEIKVRCRQCHSELIYAEATPSWSNVNSKNGGYCSTCQRTRHRITCSICHTLVRGLVNFCIRCGHGGHSAHIKEWFVDYKRDVCPTGCGCKCLFETLEYGVPEVLPPIDTVDKSRLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJF2</accession>
    <name>A0A8H7PJF2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STK19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJF2"/>
    <dbReference type="OrthoDB" id="10261701at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046579">
        <property type="term" value="P:positive regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018865">
        <property type="entry name" value="STK19-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15243">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15243:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10494">
        <property type="entry name" value="Stk19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2174850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="257" mass="29745" checksum="87555D4FD8E452D7" modified="2022-01-19" version="1">MSSSTKRARLRYADSIKDDTEIPDIYNERRKKAQKVRDKIDLDNDGAFADFEIGDLTENSVMDEAFDTYNTMKYFIYNAPLPTTSHMKNFPSNLPRICFLHQLYSVLPDNTAVDRELDILVQNLIVRKFRVGGTLEDELVIMFMTDYMAEILNAKVEFEADVEKEEASTKTKSVHSDLFDRFRETVSNHKFTDVVISRKALRNIAGFSETEISQLGWFFYVPIHKRTSGNTTIIETTANKRHIGETIENQEIKEFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PK63</accession>
    <name>A0A8H7PK63_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_001179</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-L/IML3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PK63"/>
    <dbReference type="OrthoDB" id="8864979at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025204">
        <property type="entry name" value="CENP-L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31740">
        <property type="entry name" value="CENTROMERE PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31740:SF2">
        <property type="entry name" value="CENTROMERE PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13092">
        <property type="entry name" value="CENP-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2175532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="356" mass="40592" checksum="80D9C7D2EB0186AE" modified="2022-01-19" version="1">MKRRARNSDVDDDSGDEIELDAVSRLVNRSFVAFRCTPFWDFKVEHMSRYERQFKEFMMIDLERALKEARDNGDEEEETEDLLRGRVLQVELKGQTISPWRGGESNALTKSPSRNLLSAHALSETEDPSIRPFELTMLFQPRGKPVQKAYSAVFMSALSEGSMKLAPGFSHFPLALIKADAPIIPLITRWFESNFGGHISPMRIPPWILEDVTEEWALRFYDMQDTAVQDVVRVPRTRTLDLPLELRYDTGIDELKTVTVNIPVNDLLGLIERAFFQLFSLRVTNNHSRLMDIIQLHILETTSIDVTKLILSRAGNPASYISTDGKVKLMANQSKTLTLQVMRRLMAVACENVFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PK99</accession>
    <name>A0A8H7PK99_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_005843</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PK99"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050872">
        <property type="entry name" value="PPR_P_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128:SF211">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="215"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="250"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="453"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="524"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="569"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="573"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2174781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="66880" checksum="D1CACF6819E2F75D" modified="2022-01-19" version="1">MPLRHAPLVDSVIIGVLRAIITRPGVPVPIAGGKSALLQPLSNTPHFVPARASRSLFGLKKPAHGPQLQSRLHSTQAAARSKQHTNIESHLAPASEASNSVQNRVEPSKLKKLQRNGYSRHQLRQRLGPSLYNKAKKSVLFQRFFEKGTVDKSPKPSDQVYFTRYKRPKELPSTTANVNRHVRQLVLFDGRINAATKFLREVEMRQKKDNTEGPDLKTYTMIVQGFGREGKMNSAVAWFRRMLARGIKPDVNVYTTLIDGFMRISDVDKAEKYFAEMMDSNIQPNLVTYNCMMYHATQQLDMATTEAIFARLMAAKLQPDSFTFAILINGYGRHNNVDEAWRLMQLMEKRYSTISPVIATTIMAMYRKHNDNAGVRKLYSDFFQASKDTPASEQKQTMEPTAHTHNVLLNAILAESDIGMVHNYYNHFLKTLVSAKHSARQSSKANDQSSLSNAYNFTTFMRSFLRHDDYTAVIGVYNDMLKHQVKPTIVTYGTLMLAHAFVPDPETCTRIHKELERTTALKPNVVTYTILLRAWAKVGNWDMVEQVYQEMRTRNIEPNKETLSVIRRLKTNPSEHGDPIQEGLRSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKC7</accession>
    <name>A0A8H7PKC7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_001240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKC7"/>
    <dbReference type="OrthoDB" id="10267139at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="entry name" value="CofD-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240:SF0">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="CofD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2175593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="482" mass="53119" checksum="EA7B0CA06A82E3C8" modified="2022-01-19" version="1">MDSSSTFLVISGGSACNHICDAFGQNVSFVLGISDNGGSTSELLRVLGGPSIGDLRSRLIRLMDVKQGDKVERTAIRDLLSYRLPTGGHEHAIKEEWATIVEGHHKLWAPITVEKRETIRGFLTMFDYEVLKRANKRFNFRNGSIGNFVLTGARLFFGSLEAAIFLFSAITGISESKRVIPVINTNHTATISATLENGDTLQGQCEISHPSANSCAARKRLENPIDFFSQQAVLEDNYALEFDSGNLVFSKEECQQLKSRIHRIYYNNEFGQEIYPIANPKFFDGINSKATLVYSIGSLYTSIIPCLILRGVGAAISQSSSLRNKILILNSSNDRETEGYTALDFIRAISDALNESQLIDARRKFYDCLTTERPPSPAINDALPTALAMPPTAMYQPPISLPSTPPGFPPFPSHLFSASPASRYITDIIYLSNSEIEVDVKAIERIGVRCIQVQGIIQDDGKLGYDANILGECIENIVSERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKS7</accession>
    <name>A0A8H7PKS7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_001202</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF45">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8 12" id="KW-0518">Myosin</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="828"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="866"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1137"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1536"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1561"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1586"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="16">
        <location>
            <begin position="23"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="892"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="17">
        <location>
            <begin position="1727"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="582"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="587"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="144"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2175555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1789" mass="204427" checksum="3066C1C55455F37C" modified="2022-01-19" version="1">MRSTLSSKDSTEERAEGILISGENVENLTMLAVPDETNVAKTLRTRLLNGKIYTKLGDFCVIAVNPYQQMESSAQLSTIQKYIEEYKNPRDRIERLDPHVFQLSADAYYRLRRLAEDQVIVFRYVMFLAQQNTAVISDHISYSGTHNSGKTTNRKLCLTFLSALSNHSTHKKIPGLICEAQTILEAFGTTRNTHNTVFSQCTTLESIQYNARGHISGYHVKQYQFNRAHVIQRPKYESNFNIFSYFVYGADTQEHENSHISAHNTYNYLGNESKNQSTKQRYKHMWVGFKAAFQALGLKQRLFSQIIQILSAILLLGNIIIVDESSSGGTIGIRNSAVLENIAELLGVRSSDLEGILRYRTTVINNERTSTVLTFSEANQQRHDLSMTLYSLLIDHIIHSINKKFSRSDYKNQISLLDMPPPISNSEPQDIYQLGRHYMCEKQREFLRNRIFSRYENDYKEQESSYSPFIYSLDGMHAFTSNSGIFAILNQPHENKIENIHKSESEIRKLGRKGVLSVPKAQSFVLQHYNESIHYSFETIYMANFQRDYHEEFSTLFCEGPTGSGSRNKLISELFSNDMRMKQSNAPSSSSKPTKHTSQQKSDQLLGNNGSQTVLETLVNTTNRLFSSLENSKVWLVACLLSNDISVKNSFDSRLILYQLRGLQIYQIIKATSFLHSVNFKMKDFCHRYRNALALAKATDDMSLVEQCEALSDDNGWDTSDMLIGSTKVFLSEVAWRKLEEEIREDEKAEKRQTKAKSGTSIGPSLATSYTLSDKVSSSDMHSNFSDAEVSDYEEELESTVVMAKSEKMPYIRSTPAPHAKTTLSRKLWVAFTWVSTWWIPEGLLSWMGRMKRSDMRMAWREKFTLCLLIFLLSASMIWFIAFFGHLVCPNQNLFSPSELQSRSSSGDGLVSIRGEVFDLAKFIPRHWASEVIPSSALAQYAGKDISQLFPIQISALCDGTTGNISQAITLDNFVNVSDPNARFHDYRYFTDDYRPDWYFGKLLYLRKNYRLGHMGYDPSEVRYQASNQMQFGGAKSTRMWAILNGDVYDFTYYFIGGRSVRMPHNATAPSDVNLDFIDKSIAQLFKEMAGSDVSDLFAQLPLSKDIKDRQMNCLRNIFFVGKVDARNSPQCTLSEYLLLIISAFLCSVIFFKFIAALHTPKMTKDQEFDKFIICQIPCYTEGEESIRKTVNSIATLKYDDNRKLIFIITDGMIVGSGNDRSTPRIVLDILGADENIEREALAYMSIGEGYKQNNMAKVYSGLYDHSGHSVPYIVVVKVGNISERQKPGNRGKRDSQMILMQFLNKVHYDTEMSPMEYEIYHQIQNVIGVNPFYYEFVLMVDADTEVLPDSLNCLISSFVKDDKTIGMCGETMLSNAQDTWITMIQVYEYYISHHLSKAFESLFGTVTCLPGCFCMYRIRSPGLNQALLVSNDVVTDYGDKKVDTLHKKNLLHLGEDRYLTTLILKHFPKYKTKFNPNAACLTSAPDSWSVLLSQRRRWINSTIHNLGELVFLPQLCGFCCFSMRFIVILDLLSTLVMPAVVCYLGYLIYQLAAHTSQVPLMSLITLASVYGLQAIIFIWEHVGWLIVYILAIPAFSFFIPIYAYWHFDDFSWGNTRMVLDKQEDQDGTEEVGEFDPSSVQRRKWRAYEEGFQDVPDHMIKQGKMKNEIDYGRKSYNIQYPPNMSQYPISPSMISQGRSVHNMFAVVPRYSSDTSLARTDPVYTTHSPTDEEIVLRLRDIIASADLMTITKSQIHKVLDGHFGVDLTDRRAFISKSIDEMIQDNFTMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLC5</accession>
    <name>A0A8H7PLC5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_005351</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLC5"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17955">
        <property type="entry name" value="DEADc_DDX49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="71"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="257"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="446"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2176118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="52548" checksum="6A429DA528487A45" modified="2022-01-19" version="1">MATTTTADASILSDQRKIFEKDGSKSSSEVALNRAKNKDTTFENLGLSSWLVDALSSLSIRKPSEIQKACVPAILSGKDVIGGAKTGSGKTAAFALPILQKLSEDPYGIFALVLTPTRELAFQIAEQFRVLGRGVNVKETVVVGGLDMMQQALDLSRRPHVVIATPGRLRDHIQSSSGAADLKRIKYLVMDEADRLLSDTFTEDLEVIFNNIPEKRQTLLFTATMTDSILALSDAEEDPKKRPFLYQCDTSISTVSTLDQSYVFVPSHVREVYLVHVLRSEDFAGKSVIIFCGRCRTAEMITVMLKELGIRCTALHSDMSQQQRLDSLGRFRAEVIDVLVATDVGSRGLDIPTVQLVLNYDIPRDPTDYIHRVGRTARAGRGGQALSIITERDVQLVHNIEAKINKQMEEYKINENKILEELSEVTTAKRVARMHLHDTNFGERRELRKMKRQSEGASPAAKIKSKAKKANGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLD5</accession>
    <name>A0A8H7PLD5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_005366</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLD5"/>
    <dbReference type="OrthoDB" id="272245at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11367">
        <property type="entry name" value="RNase_PH_RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="30"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="223"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2176133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="308" mass="33633" checksum="B859A1D2A02B49EF" modified="2022-01-19" version="1">MPYLSQAERDYITEGVHSDLRADGRGRLDYRALVLETGIISQANGSARVRLGGGTDVLVGVKVEIDQVEPDAADIGKVVCNVECSPSASQQFEGHGADDLNNELTQALQRVLGGPQCGINFEKLCIIKGQQCWIVYIDAMILDYSGNVMDAIFIATKAALFNTRIPKTQIQDMGDGEFEFEVLDDVEDAERLEGVENVPVGVTLNKVWTVMTGSTKLNKEHATPLEELCTEAKLLIAVNKDGKVCGIQKGADGSIEPGLMSEMIQTAKRVGQSLIRQLDQSLHNEEAQVEEKRRNGEHVEKLGFFAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLR8</accession>
    <name>A0A8H7PLR8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phytanoyl-CoA dioxygenase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_005576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLR8"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF46">
        <property type="entry name" value="PHYTANOYL-COA HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2176342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26255" checksum="424B3DEB691C7B3F" modified="2022-01-19" version="1">MLLSDSQCQSFAHQGYVVFEHALSPKQCQSLHEEADVLLNHAMNEGLDLVRDLGCIIEPLNCAYTDMEMRDCRDNIQRYKEQRDSISDNHVSSLILDIIPRWSAQLLRSDIVYLLNEQYIIKPPSAGTGSSFRWHTDGEYLPADEQHINSVACWTALDEVDQNNGSLTIRPMDGGADMEIKVPAGSIVFISNRVVHKSTPNNSRRFRRVYMPQYSSKRSNVGFRFDISIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLV4</accession>
    <name>A0A8H7PLV4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_005358</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLV4"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060258">
        <property type="term" value="P:negative regulation of filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001382">
        <property type="entry name" value="Transcriptional repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="27"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2176125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="247" mass="27065" checksum="69408BDC11747DF4" modified="2022-01-19" version="1">MALSVKDASGRHISLLNSSSPYGCYYTDGSTPSSGPSSPSSDEDSLHMATRPHSSSSRSSSTHSKRRYQCMEPGCNKSFTTSGHLARHNRIHTGEKNFACLYPGCPSRFSRQDNMMQHYRTHMSARSRSRVQSQNGSVHSTAASNMPRPHAHTRIHSDSSAITPLNQSQHTAIPSEFPPTRHLEYFSAPSSPSLPPLHKMMQDSPSLDISLPPPKTMLPVPKNIRQVDENTSSSGLLQLAHIVSTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMH0</accession>
    <name>A0A8H7PMH0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Vacuolar protein sorting-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_005397</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000008">
        <property type="entry name" value="trafficking protein particle complex subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
        <property type="entry name" value="VPS13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="6">
        <location>
            <begin position="182"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="domain" description="VPS13-like middle region" evidence="7">
        <location>
            <begin position="1385"/>
            <end position="2070"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="8">
        <location>
            <begin position="2138"/>
            <end position="2698"/>
        </location>
    </feature>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="9">
        <location>
            <begin position="3225"/>
            <end position="3330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1034"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1231"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1567"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1752"/>
            <end position="1773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1034"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1237"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1572"/>
            <end position="1591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2176164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3356" mass="378572" checksum="409CB3D6439666D6" modified="2022-01-19" version="1">MSFLSPSTSGIFGGGSHEDGSMIAGNSGKLVNESCLDFLMMELVDAMCRSALDEDIDREVVFYKLEMLGYRVGQSLVEKFTVDRPRFTDTLDVVKFICKDLWVIMFKKQVDNLKTNHRGVYVLQDNNFRWFMRMATDIGGADSSTKATPYLWFPCGVIRGALANLGVSSVVMAETSNLPQCDVVLRDLQLKREALDKFDLPVDVLEGHLGELTLSIPWSNLRNKPVKVYINNVYLLAVPRNELNMTEEERNKRNQQLKKDKLTNAELLSDPSKHAPPSTVDPQEEAKNESFINQLTTKIVDNLQFSMKNIHIRYEDQGSDQYQPFAAGVTLGELSAISTNSEWVPTFISEATNTIHKLATLESLSIYWNTDSRSLAGQEDAMAAFQELITTKSNTPKEHQYILKPVSGTGRVNINKRYGGDTPNLDATLLFDELGFVLDDEQYRDILAMVDTFHATLKKQQYHHWHPPKGSNPKTNPREWFKFAGNAVLSEIHDAHYRWSWDHFKERRDDRISYLDCYVANELHRATQEQVAILNKLEEKLSYEDIRFYRSIAKNRLRRERAVIAVEEERRKKAAAKHPNQAGWISSWWYGAAANPSSDDDEEELQMTDEQRQELYDAIEYDEEKAVVTEAVDFPKDTMNISLKTTLNKGTFMLKREPHSENPVVLGSLVFDMVTTNLIQYVEGFKATAALGDVRLYDDITEGTLYRQLIGVKDKQESGNDEDSPYHSISKWQSSRSQPFFSVDFEHQPLDGRADNALSLKMHHIEIVYNPSIIGEVVSFFKPPESRMDSINALIEVAGDTLEGIRKQTRAGLEFAVEQHTTLDLRVDMDAPIIAIPEDCTRSNTEVIVLDAGHINVESKLAPPDALDALKSKSKENYNAEDHIQLQSLMYDKFTVQLTQTKALIGHSVEACLEQIQDPKSENDYLHLVERIDMTFLVEMCILPTTTEMTRFKVSGHLPLLSVSFSDRKYRTLMTIIDLIVPKSEDENEPSTISDEGQTGEQIGQTGDIAQRHGSRSNVLAKKLWSQSEVLIDSESEAETSDDDDSASVAQSTNTIDTEVQDHDNATIRKGKGTPRVNLQQKLFVFEFKVDKVQATVSEVAKGSRKKEELLCDLIFQHFQLQFALLPYHMDVEVALKSLNVVDRMSHGHEFKYLVTSESIDDTDDEVRDSKNLVNVHYIRVNPQSPELQQKYNNITQTADVTLSTLNLIVTQSSVLRLYNFVLTTFASGDGGRRDQTTSANLGKPRSSSNAGFLGRRLSSTADAETQQAVRTVAANQAQQSSNIKVDLKLESVTLILNNNGTRLATGALSHGTMDILMYEEKLQVAARFGNFVLTNDLHNQLPSHLRESNKRLLTMEGDELADFRFETFSPTAANYPGYDQLLFFRVGAAQVTFLEEPLRQVLQFLSTFAEMKSVYDSARQAAIESAQQLQQAVTKLHFDFLIKSPIIEFPGATSKSASNIIVARLGEISATNSFEDDDSIQGYLNKIKAQIQSISLSSKPVHEQNLTNQLPIINDIDLSFDIEYSDGTLAERPDIKVLGDISDVRMNLTPQQFASLLETINAVSRALSGPPNENESQDTSQGADVSNKEISANEEDVDETLGNYAEITRLQMVMNMKQTYLELFSKDADNCDEMASMSLAKFSLNESQMTLNMARDTSMKLDIDIQSMNMSDTRPELKSRYKEIMPANKQSDPQVSVHIDISKPEPQRHGIVIVELHSPKVILSVDHVFSLRDFITIPFGPESNAQKYAYETQSKPSPTARRTSVSSVQNEQQPGMELSYRINITDIEAVLLANPSSPSSEAVILSAQQIMFSQQSIMALVIKQTGMFLCRMDKRKETTLSFIDTFDISMSRDDKSSTPEHSILSYIVDVDPLVLRLSYRDAMLIWGIINKVIELLNVDSQDSIASNGDDNADDKAVATMVKRKSINSTASTLANMPHKNKHSSQDASGPRVANEMLKATFQGMRLVLIEDIHELPLVDMNLEQFSIKASDWTKSLMVDVDFQSYANFFNIKNSHWEPLVEPWKFNMKLSKPSSDEPYGMQISSRKMLEINCTHTFTETMLSSLSTWDQQKDASLGANRGSVAPYTFRNWTGYKLHVWSIVDDDNNNTVVETLANGQEIPWRFDDWRTRRQAKYRGNNMLGLQMQGGPLWESLKNVPVDHEGEHMHVLRPKIDDVSHRIVVDIKLVDNVKVVTFRSAMVVENRTLLPVDVVMVDNKGNMASDIHKILPGDDYAVPIESSYHHSLCVRPDAGFGYSWSRQQIYWADIPQNRCPRSLACYPGERGPPPFRFQIHGRFDKKNPLSKYYPCSKIRLSAPVEIENLLPYDFNFRIVDKDTGQDFSSFLRKSGTSPLHVVEMGHLLLMNIHMQESAYQPSEFAIISTRDTDDLMIDDKLILLDKDNAKLTLRINSIEIPESGGAHKFSIYCPYIMLNKTGRDIVYKAKPFMQGARFTAGQNSVQRGDRKAEPFMFSYSKMDNRNRCLIQVPDSGWSQPLSLEAVGSVQDVALPSINRVEEFHVGVSVQEGQGKYKLTKLITFTPRYILRNDSGHDIKYREPGSRSDSLLEANNSSPLYFLRQSAEKQLSIKFPGVSNTWSSPFSIQDIGKVHVRLDSEDGSPPTLMKVSMILEDATIFINFKEEKGKWPYLIVNETSEDVLFYQEDPAMQDEYGNHLQTRGVRKYQLKSNDSMRYSWDMPAVKDKQLIMSVHGRERRINIQEIGDQIPFRHRTRDGGWDIMSIDVIAQGSTQVLRLSTYNQSQSIYRPQKQLASSASSVASSAREGFETVDVQHIVNFTFIIKLAGIGVSVVNKHMQEIAYATARDLDVKLTDSNMYTSLRTTIKWLQIDNQLFGSIYPILLYPSALPKNADGSLMVPTFQLGIDRVKDDTHGVLFFKYFSVLLQEMTFEMDEDFLYAIIDFTQFDVAGWNAAETQVQLCDENLDIPEPKTTDDVALLYFEAFNIQPVKLNLSFVRTQGVNILDERPTGDSAIMFLINVLTMAIGNINEAPIRFNALAAENMRVNGSDLVNRVTLHYRDQFISQIHKVLGSADFLGNPVGLFNTLSSGVAELFYEPYQGMIMSDRPQDLGIGIARGVSGFVKKSVFGFSDSFTKFTGSIGKGLSVATMDRAYQDRRRINMTRNRPKHALYGVTAGANSFANSFASGMAGLVKRPIEGVEKDGVGGFFTGVGKGLVGAVTKPMVGVFDLASNVTEGIRNTTTANDDIIDRVRAPRHVGADGILQQYSRREAQGQFWLKMAEGGQYSSENYISHCEVQDNEVVAILTDASIMLIRIRRLTVDWREPFTEIQTIKCEPTGIAIYLRSRAWEPFIIISDKKSREEFFSQIESTVMRWSRRVRPEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNJ6</accession>
    <name>A0A8H7PNJ6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CSN8/PSMD8/EIF3K domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_008029</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNJ6"/>
    <dbReference type="OrthoDB" id="5351233at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010387">
        <property type="term" value="P:COP9 signalosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033205">
        <property type="entry name" value="COP9_CSN8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13339">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13339:SF0">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="CSN8/PSMD8/EIF3K" evidence="6">
        <location>
            <begin position="39"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2177372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="200" mass="22576" checksum="8788CBE7409C8608" modified="2022-01-19" version="1">MEDIAQKIVDKDYLGLIDTCEALEFEIAAFPHDSVPIAHVYSTLLTCYLIVNDLNSARFLRKRILQHYKTENQVPELLNAIWQVGTALWNKALPEAYIALDAYQWDDDMKPLMLALKESIQENAYNLICQSFSAIRANSVATMLGSSEDALAAELIKRGWTIDTEKQIWNPVKAVALVQHNISLSQLSTLEDTLVYLESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQV0</accession>
    <name>A0A8H7PQV0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_001630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQV0"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000027">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="280"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="109"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="545"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2178784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="681" mass="77417" checksum="BE6FE4A6A2093536" modified="2022-01-19" version="1">MPASTAASEISSDGDEHYSAARESIEQDQANREKTGATGNGRPSLHKAQDSIHSLESDTTTQSSQSSLRRRSSQRASIGNVASMINKYSQEAMQRRASLKETPINEADLNEVSLDNDATDQSAPSAAGGRRRRMTVSNRDAPNNLRSNPLMPLPQDTLQGATVLPHDDSDSSQTGSVSNLSTQDSDHHTRPSRSPTVGSNYDLLLARLEVQDKNNDPKSKVYEEQQIEEIKDGFERVYNEAVSKGEEDEIDWEFWGTVISDFNNVAKTQPKELSKNIQHGIPPALRGMIWQLFGKSKDPELEEQYMVLLKEDSVYEKAIQKDLNRTFPKHEYFEKDGPGQQALFNVVKAYSLYDTEVGYCQGISFIVGPLLLNMPEEEAFCLLVRMMKQYNLRGHFTPQMETLHQRLYQFEGLMKEHFPHLHRHLEMQGIRASLYASQWFMTLFAYRFPFTHVYRIYDIVLAEGTEALFRFSLALMERNQETILSLDFDGLVHFLKNEMLDTYKDDPRGFVGDAYAIKITSKKLDRLAKQYSSEAAKASGEAEVLDTLRKQNKQLKDSVKRLETSVNQLNGEHITVANRLIESKLEMARLNDENDALHQQSNELKRALDTLPGEVEARVKEEMEILCTKNAALVERNSALEEQLSYMESMIIDIKMKFAESENERDTLRRKLADMKKLMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PR58</accession>
    <name>A0A8H7PR58_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_001643</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PR58"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06564">
        <property type="entry name" value="GH20_DspB_LnbB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052764">
        <property type="entry name" value="GH20_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43678:SF1">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43678">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034866532" description="beta-N-acetylhexosaminidase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase bacterial type N-terminal" evidence="9">
        <location>
            <begin position="29"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="8">
        <location>
            <begin position="172"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR625705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2178797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="728" mass="80134" checksum="30D31FCA67F0ED78" modified="2022-01-19" version="1">MKVLGNWCTIFGVLSLAIASQAAPKNNQPVVVPSLKTWTSGSGHVQLTHASRIVVDSNYQSENDQASRMENPANLKDIAATLADDLKTISSLDLSVVVGKPRNGDIYLELGELKNQTSDEAYLMKIATSSITVTGPTSRAVYYGTRSMLQILVQSNGKDTLPAGETLDWPTYPIRGFFLDDARKYFPLYFLKDYIRFMGWFKLNTFHLHLNDNDFLSSPTDPTWKTKYAGFRLKTDNPALSGLARGEDQWYTQSEFRDFQDFAKANAMTILPEFDSPAHSLAFVQFKPEIGAYPVLDNSYLDLNKTIAFTFMESVWDEFAPWFDSKTLHIGADEYPASQAVQFRKYVNTIARYIWEKHGKRAQVWGTGIEFDPANKSSIDNNITISHWANWEDNPANITLDGFEVINVNDGGPCSTYIVPKSGGSGDSINDVNFLTEYNPPIFGAGYNLKTPEQLSKLLGGMFAVWFGLMTGDAKPDNLGNSTTKWETHSIVGNTMATISQIVWNGSQKDADPDSFFTNVEAVTQGPVNLKLEIPTKGDMIIDYDLKGGNGNVLQDSSGNGYNAKLSNINRVGQGNSSALAFSGPSSQATINLGTKGFKSTLAMQITIKNTKLQTLLSSDQGQLQLSQSQISISNDNYTYTVDFNTTLSKTTNIAITSESYPIGSKLYLDGKFHGNFTYLIPRTKSIVPMGLVTPLDVLGGGFEGSLSAFQIYNHVLSQSEISKLAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRX4</accession>
    <name>A0A8H7PRX4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_002012</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRX4"/>
    <dbReference type="OrthoDB" id="7827681at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000012">
        <property type="entry name" value="Voltage-dependent anion-selective channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0626">Porin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2179162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="299" mass="31978" checksum="A734893C9417B89D" modified="2022-01-19" version="1">MQQSLDTIFSSFNIHLLLYIVAFNDIGKASKDLLSKDFPVGSAKLEVKTTAPNGVTFKVNGLRDNKSGVIVGDLETKYADRAKGITFTEAWTTSNHLNGKVELENNLAKGLKLEILTSLLPSVNQKTAKVNATYKQPNVHTVASLDVFKTHFSVNTVVGHEGFLAGGEVAYDVLNGKISRYNATFGYAAPVYSVAVHATNNLSHFAASYYHRVSADIEASGKAAWDSKGTNPVALEVGAKLQLDPTAFVKAKISNNGVVGLGYTQALRPGVKASVGASVDTSKLNENAHKLGFAFTIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSI6</accession>
    <name>A0A8H7PSI6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_001590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSI6"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="56"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="481"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="765"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="571"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="595"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="632"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="655"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2178744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="878" mass="98403" checksum="D70C6EAEC5E760D3" modified="2022-01-19" version="1">MATAAVRPQSAAYSDVRRSASAEFHSHTGQSSVKRTASAKTPRKSRNKSPEVIGDYLLYSTLGQGSMGKVKLARNRITGQLAAVKILSNQNLKDPAHKSKDPKDTPEHRLRRTQREIAIMLLLNHSNICKLLHWEIHDNNYYIFLEYVDGGQLLDYIIGHGKLKERQARKFARQILSAIDYCHRNSIVHRVKQSTDKLFVVLMTDLKIENILLTRDENIKIIDFGLSNIYSPQSALSTFCGSLYFAAPELLQAKKYTGPEVDAWSFGVVLFVLVTGRVPFDDTSMPALHSKIKSGVVNYPDHLSRDCVDLLKSILVVDSSKRATIAQVAAHPWMNKRYDTAIDNEMPRRKPLQLPIDRKIVEGMHGFGLGSVDEIQKKLEDIIESSEYQQAAQVIENTPKTYKIKYVAQQQNKWRLKEQPPKRVIVPSNDDPQSQPAMFDPLISIYYLVKERQLVYREDLIHAHEELVPDLGVSEKPTSIITNVKSSGSESDKKTTQSETSGDDAANNHIKFTKSTKVDDGVPPNSPPSTDSKNERRASKRLSNLFQSKRASWDSKRHPSDVSAGRCAGRVAKDNQDEQKEATAPDASPVPPTPSISQSTPVNRNILQKNVSNIGRRLTFKTKSRTKLAEQPAKDSKLSNDQTRASDHTARNADKPSSTKLPTRSSSPVSFRREGGFAGLFRLHSPKSHLKDMMKPRQEALQGIKGFAKHQLFHGPPEQVLQHLLQGLEQLQIDIVSKGEFEVQCRWSGWKGYLAARSSNFFNGNSDSSRSSDTLDSVDQDAGSSPLPKEANGKMSPTYALKRHVSVRKSSPTSTEALQQLEFSVIVFSVTWAKRFGIRVQASPDQDKDRFSPLFKKTEQLILEAVETRCKQQPLITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSU0</accession>
    <name>A0A8H7PSU0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_003680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSU0"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF24">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 3, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="86"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2179894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="313" mass="36831" checksum="D8A9EDD78D4F4E5F" modified="2022-01-19" version="1">MNIITNITSATKRLATVLTLITRFAGAMHLCQLTSFVIAPFSERIVFDINSKVCGTVWGFMQWIFERRKKARITYSGDQLPKKESAMVISNHRSWTDFYLLHSIAIRRGMLSNCKYFIKDSLKWIPFFGWGMWLAGFIFVRRTWMRDQHRVNATFAKVDRLKAPIWVMSFVEGSRLTPEKLRAAQEFSEQRDLPIMQNVMVPRVKGFVACMSKLRKSHVKYLYDFTVAYRHGGTKAGFGIAPNMIQIHVLPHLSPEYEFHVNVKRYAMEDLPSEEKELTHWLRERFMEKDAFLENLKENWVDGLDEEIWTEDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSW1</accession>
    <name>A0A8H7PSW1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSW1"/>
    <dbReference type="OrthoDB" id="9932926at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006993">
        <property type="entry name" value="Glut_rich_SH3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04908">
        <property type="entry name" value="SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="225"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="507" mass="59215" checksum="6E50D9F2E3484938" modified="2022-01-19" version="1">MPCFGTRKKSKNGVGSKYETDPKLQEDFNQLKSKNEHNIHIIAAQTEELDRLRRQISEQSLHNNATNNENLVVLRLRNRQTLEALLEKEKMLQQRDNELERLREQLEAERNVQQIESMNFISRPLPEHLDEEKLSRKEKELRKRENELEVEMKRWEMERAEAVKPALSEVEEQLKELKVKNNEVLARLSERERELERFQMQPQSRRHSIMNDDEAKKFRRLTVDVENDKVALKKLKELALDLKAQKYNHQALLDSHAEAMAEKDKLLQEQQQELEKVRLAHDNATRRLERDQKQSVQKLKELHTQEMENLQLKLVDAEERAMSAVDSEVEKVLQEFEQVEHSHNMRIEELERSHKNQMSLMARDQKQQLRYLKSKQHDETKRLSWRPSSGAEQSMVTLRRTGGPGGSSRRVPALLEDARGPELTPQDKTKVQVYVSSICSNVAIKQRQEQIGHLLSAHNIKFEVIDVAASQPALQYMKRQNNGGSSRGRAKELPQVFVGGQYHGVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PT69</accession>
    <name>A0A8H7PT69_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_001647</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PT69"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005990">
        <property type="term" value="P:lactose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050347">
        <property type="entry name" value="Bact_Beta-galactosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323:SF2">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="LacZ_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta galactosidase small chain/" evidence="9">
        <location>
            <begin position="824"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2178801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1113" mass="126778" checksum="C4ACE7F0C5D4B1BB" modified="2022-01-19" version="1">MTFTVNQEWDDPKVVGINTLPPRTWSFPAESAESGLARITSRGHQFPANALSCKDKVHSLNGFWDFKLYPNPRSVDSNWFTQQDNEFTQIPVPSNWEMVGHDIPRYTNIVYPFDLSNVPHAPTEDNPVGCYRRKLSIPDGWECTDKRDRIIVHFSGVKSCIYLWVNGQFVGFSKDSMTAVEFDITGNVNPGEDNVLAAQVIRWCDGSYLEDQDFWDLSGIQRDVLLYCVPAEHGYLQDTQIDTFADGTLKIRGQLYCNSTPKDATLRVVLRDLGEDQTHLFAESYQVDSLLEVKQEKEDGQTYSLKEIVEQVQNAKQWTGEAPHLYGVTVELIKNDQLLDCRAWRVGFRTVSINDQHQICVNDMPVMFRGVNRHEHNAWRGRYLTEKDMLEDIHLFLQHNVNSVRTCHYPNSPRWYELCDEYGIYVMDEVNIETHGMHLLGDWDRLSKDADWKDAYVDRTKRMVQRDRNFASIVIWSLGNESGYGQNQEAQYDWIKSSDKSGRPVHYEGRPPDPTGQSVEAVNSTSNVKKYSAFDINSNMYFSPREVQTATLEDTERPVVSCEFAHAMGNGTGNFEDYVEVWYNNSRTQGGWIWDWVDQGIALEIRENNPGAKYHLPNPDITHEIAKGNGCWLYGGDFGEQPHDADFCINGMVAPDRVPHPGCHEMKHCYSPIALKLVQCDTTYTLIEVHNRFDFKTNLSEEYKVAWEVWDESSHKITSGYESLPSNLSPRQKQRLLLKHEETASFLRSKKWSGPKQVFVNINIVSTTAKEWAPKSSLIAGWQFEVPLYEPGGMPSPAKFADIESVSEKEAVEIVDDKDQLILRSKDKSASATFSKSNGKLTSYTVDGHNLLVEGPSPNFWRAPTSNDEAGGNDSYAYYWRQAGLDNLKAQDISVYKVTHDSVRVTGNIPLTKPLGTIDYFMDYKLDSATSELYVSVEYSIKFEQDSNIFQSLTFPRVGVSLKLPTVTSSQYRYAGLGPFENYSDRKRAAFQGIYTIDIASDEVPYVNPQAYGNREEVRWIEITNEDGRQGIIATATQRSVFSTSVHPYSQENLTAAKHLDEVKVDDVVHLYIDAAHSGVGGDDSWSRRIHKQYLVEDSTYGLRFKLGKPTHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PT74</accession>
    <name>A0A8H7PT74_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Maf-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PT74"/>
    <dbReference type="OrthoDB" id="10267058at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2179089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25084" checksum="F2FCD6FD58981A2A" modified="2022-01-19" version="1">MAMSLNVPHLQSLKTKNVILASASPRRREIIKNLVRIFGLHFRVVPSQFPENLDKKAFSKPSEYVSETSKGKALEVYQRLKHENESADLVIGVDTIVVIDNMILEKPATQERALVMLRELRGRGHSVFTAVTFIYPRKNDPEHHVVKSFVEETLVEFSNISDEGLQAYVETNEPLDKAGGYGYQGLAAFFIKKIDGDYWNVVGLPSCRLYQELEALCTADEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTE1</accession>
    <name>A0A8H7PTE1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTE1"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="1">
        <location>
            <begin position="129"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="257" mass="29464" checksum="DE5496EEB4822549" modified="2022-01-19" version="1">MPTQHKNMSKSLGKPDKFAFKRSAFRSPVIQKKDIHPRELTESIDHKIRCLQENVSLLKHAYMIQEKDEYGKLENLVAKWKHVAQEVTIEIFSIIQSPLDFTTSSFDAILHPAQISEASTQQHNGKPILRSNQLPHLLPFVQLITEKCSITPLVIIIALIYVKRFRATLPSGYKTEANTAHRIFVSSILVASKFIDDDPITIAQIVHASGDVWTMKETARMELAFMKFLRWEMYVPEEEVIAFLNEHRFAVDLVLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTX8</accession>
    <name>A0A8H7PTX8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP adenylyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_004046</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTX8"/>
    <dbReference type="OrthoDB" id="10267950at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000846">
        <property type="entry name" value="ATP_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="2">
        <location>
            <begin position="183"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2180257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="36337" checksum="022BCADC2EAAE215" modified="2022-01-19" version="1">MSENLENLETNIKEKYDSALKSQDLYFFETTTESKDVNGVEFQLTHAPSLLLKPKPEGLGPPEPTDPFENPNPALLVAEYGEYNLLLNKFCVVPHHFLIVTKEFRKQSEPLLPSDLRATWEVLNQVSQPAMAFYNCGDVSGSSQPHKHIQVVPLAKSTHSPPINALYDRISGRKAGEIYTIESLPYIHVLVPLDLNFISTSTDPEELEGYLGQMFFGLLDSMIQQLRVNGSRMTMSYNFILTKQYMMLVPRQKEHWEVPEKGVRLSVNSMAFAGYLLTKKPEELETMKESNILDILSEVGVPKNMESSVHIVDHHSELAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PU01</accession>
    <name>A0A8H7PU01_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_003972</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PU01"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008726">
        <property type="entry name" value="PRK11728.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF3">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="83"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2180183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="501" mass="55618" checksum="A32152DE1B87CC2F" modified="2022-01-19" version="1">MQYALPLRSSARTALYRRVPTLLGQHTRLFSASATPHIHLWDHLPGEEIKEPREGLAKLKGKIREERFRRKPQINFAEHDRFDVVVVGGGIVGLATAREILNRYPDKTVAVLEKEREVARHQTGHNSGVIHAGMYYEPGSTMAYTCVKGAQMMYDFCEKHQLPVERCGKMIVAVNEAEHKEVEKLYHQGNANGVKGLEIYDSKKVSEVEPNVRAYSALYSPNTGIVDYGLVSETLAREIIDTGRADIKLAFEATRFDKLQDGSVEITGIEPAQKGPILSVNAKNVITCGGFYADRLAGLTGGNPHKDQVVTFRGTYYQLKPEYRTMVRMNIYPIPSGGGIPVGTHITPTLNSRRGHALIVGPGACFTFSREGYQFFDFKAKDVWDSFTNTSFWAFALKNLGLSFGELYKDINKRAFMRAAQAYLPDLTLDMVEHSFSGVMPQVFQKGGIAASDYILERKVLGGTTLNVRNAPSPACTASLAIGEMVTDTAAEDFGWPKIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUD4</accession>
    <name>A0A8H7PUD4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box/LRR-repeat protein 15-like leucin rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUD4"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="1">
        <location>
            <begin position="237"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="470" mass="53763" checksum="35AF71609AC8DFEC" modified="2022-01-19" version="1">MTTAMEGPSYSKMAAEAFRRNADISSESTHDGDDIGSLAMLQTQMSGTSLSDIRNPFHRLTRITMAAMPIVFAYLRNNELFRCALLNRELHKSAIALIWGRLDFSSPSYAPMKMLEKFLHSLPSLPQSTLELIHEIDMTEIDESIYDTVPENWLSLIVRYCSELRVLIVSKARYLSPASVRKLHPYAALTKVHTLDLSYCDHLNEMVLKRIADLFPNLHTLKLAHISGLSDGALSELVYTCHNLSSLNISYARSLSNASLYSVAKFCTIRLRELDLSNNERISDEGLAILAKYNVHLTHLNLIKMSKITDFGINSIVKSTSRHLKHLQLHDCKNLKDPLHTMRRIAERCQVLESLTISWDMIKKDVAVLEHFQSPLTELTIRKLPEHTPMSVLERIVDFFRGRPLRTITFTRDWYSSDFLYGSYTEVKASEYIEVTADEITKFNLKSESPTIVLLVNERETDTSYDMHNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUG1</accession>
    <name>A0A8H7PUG1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003742</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUG1"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="62"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2179955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="156" mass="17414" checksum="D2A4CB2D56F28F87" modified="2022-01-19" version="1">MKIDPQVESKFSRLAENVQMWNTHHDNTWDASISENLTIIEARPDFLVFEFEVAENHTNGIGNLHGGCVATLIDLCSSLAILVSDEKHVQWRTPGISTELAVSYIAGAPEGTKLRIENELLRSGKTLANLYTKIFNESGKLCYSGTHTKFCMDSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PV16</accession>
    <name>A0A8H7PV16_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PV16"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF184">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2180837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="42822" checksum="B4DF60EDBB168A65" modified="2022-01-19" version="1">MSTEPALDSVPADQQGSFSSFLKTLASFTGDLSNLTCPSFLLAPISLLEYSAFWVDQPSLFNEITEPESAEERFYAAVRWYISALNGSFASRVPKGEWEKKPFNPVLGEQFFCSWKGDTSIVCEQVSHHPPISGFFCENKKSGVYLNGHDGQKTRFSGTQMLVDQVGHCVIHLKNRNDETYLFTLPSLSVNGIWYAAPYVELYGSSYVQSSTGYFAQIDYSTKGWISGELHHFKATVSHEALKGPTVIEGQWTAKSTITKHKQSAAPFLDLTSLSREAPIVKPVDEQSSFESRKLWSKVSEALLAGDYAAASTEKSLIENQKRAERKDREVSGEEWHPEYFVKVDGDKVYGELNEQLAANSKHKYQEQDGFSWVYKDYVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVK1</accession>
    <name>A0A8H7PVK1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6729 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVK1"/>
    <dbReference type="OrthoDB" id="2287981at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046616">
        <property type="entry name" value="DUF6729"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24401">
        <property type="entry name" value="SI:CH211-243P7.3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24401:SF29">
        <property type="entry name" value="SI:CH211-243P7.3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20499">
        <property type="entry name" value="DUF6729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6729" evidence="2">
        <location>
            <begin position="177"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2181394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="657" mass="73331" checksum="542A2AAF51FDECEE" modified="2022-01-19" version="1">MEPDDQGHMEDVKTTPAISNTGMDSNSTALVRFDADAKNPKTVKATNGTRSGVKAVFDEPLDENEPVLNSSQAQGFDGYTGDNRNNKNKRDGEYNAIDLDKATWSYLKRSCCLGTSLRHSEQAYLTFGENQIEDNHRDKSDDDEEEHEEDRENHKDMPPSHLAEYFEIIQKRFTVDKKIMEYERGTCWIEPPDPVFPLQSSADSNILLKPRLFIWAPNLLQPVALTCPKCKSQLSSQGWNKSPHARGVLDVDRSFFIMSTRFRCARCPVTLNAHDINILKQLPMHLQEAFPAYMTHRSAISKTLVDVMRPLMNIMSPKGFTRYLKEIHNARLNRLRVQCQKNLMITKPHGLTSDNSGSSKLTATNSQKKIRAAATKDVPQPQELKVKIQPILPNFSRSTPQFIPIYIPTSRTAQFIPPPPMPMRIAPLQKPTAPAMRPILPARRDINKHPALGAPSMMMRMPIPGIKRRITAIGRHRRPRTCKTCNSQVCPGRAQSKRCKFSKDSEDVSESLPAEDLAVSDTATTNNTLETENEQQASFDTSDNEHPHPSANNASSEPPAPVIHSPPSPVQETNDIPSPVPTSDIPISVPETSDTSSRSSEIPAGVTKSLQPLAQKPLLPTSSDKIQIPRLTYPVPSKRRPLRFTQVASASDVKKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVR7</accession>
    <name>A0A8H7PVR7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVR7"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010708">
        <property type="entry name" value="5'(3')-deoxyribonucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052419">
        <property type="entry name" value="5_3-deoxyribonucleotidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35134">
        <property type="entry name" value="NUCLEOTIDASE YQFW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35134:SF2">
        <property type="entry name" value="NUCLEOTIDASE YQFW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06941">
        <property type="entry name" value="NT5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2181128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="279" mass="32355" checksum="E9B524F8C745711B" modified="2022-01-19" version="1">MPSVSHRRIVAVDLDDTLAHTIEALAAWHNDTYDTDLKHSDFHTQNLWEVWGGSREEACQKVREFYTSKHFLDLEPINDYALESLRMLKRRRFSLVIVTSRQQLVAEETKRWVDKCYPGVFDSIYFCNLYLTNAEQQELISKPKSAILREINAELLVEDSLEHALECAQVGVPVLLFDKDGQYTWNHLNIDGKGVQEADAMILPHNVTRIKTWKQVVAHFPKPASPLRFCWVPSDFVNSDDEESDDMKTVDVDDMSDDDNQYFQDGEWKKSSSRELVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWB4</accession>
    <name>A0A8H7PWB4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 2</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD2</name>
        <name evidence="15" type="ORF">INT43_008510</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Endosome membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWB4"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00663">
        <property type="entry name" value="PS_decarb_PSD_B_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033179">
        <property type="entry name" value="PSD_type2_pro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5035016548" description="Phosphatidylserine decarboxylase 2 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035016547" description="Phosphatidylserine decarboxylase 2 alpha chain" evidence="12">
        <location>
            <begin position="962"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="242"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="552"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="565"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="819"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="875"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="962"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="962"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="961"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2180930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1003" mass="113259" checksum="A0B7A15756569AFF" modified="2022-01-19" version="1">MTNDTVEELILRCSVIKAQDLVSKDSNGFSDPYAIVSNGKDFHSSEVVPKNLNPEWDFTCDLTLTPGDSQISIVLWDKDSFKSDFLGQISFDVQDLFKSGQAIAFHDDNNEPRWYELLDRDTRRSKILRRKKKLADQPKPMSSGKVLVKLGLVERYGTAAPENWESIWDAFLNSAARSDAIEKPDQPSTADQKSQNTATAKRALLQKYRTTSNKSIDTSTAKFHGEDLMGIMYIEVTCASDLPPEKNGKLHVNDPIANKYILAYLDTRSTNVVILMIHTTFDMDPFVVVTFGRSTFRTKALRHTLNPTWNEKLYFHVNDDDINYKLKFSVYDKDKVSGNDFVAGNEVSILDIINKSLESGKLALKPASTVGAGNKGTDEEDHIRLTLGNSSEGSAAKDIGSDMEMHTIDLKLANQAKWEGRHQPTLTFRAKYVPYEEIRKMFWLTLTKTYDADSNGRMSHMEVQTMLESLGSTISDSTIDEFWSHFNKTEDQELEFEELIDRLEAHIVYSDRRRREAKKAREPTEGLDRSDTSNSLFLDPIKFYQYDSEMSSDNFNDNSDSEDTLNDKDHASFASSDHDEPLAEAHGVQYGVHDNHEQTYDVSSDKDVKLKDDDVMENENDNIEKVIHVKECPICHRPNLNRKSQMDIITHIATCAADDWTTVDKFVMGNFITEAYAQRKWFVKMISKVGYGKYSLGTDNANIIVQDRQTGQLIEEKMAVYVRLGMRLLYRGSKTTVHTKRAQKILENMSMKQGKRFDSPMSARDIKPFIQFHKLDMTEVLDPMESFKTFNQFFYRKLKPDARPCDSADDPNVAVSAADARMMAFATIDDATRIWIKGMNFSVGKLLGDEELGKSYVGGSLAIFRLAPQDYHRFHSPVDGVVSEVKHIPGEYYTVNPMAIRTTLDVYGENTRSVLSIDSPTFGKVAVACIGAMMVGSIEITAKPGSTLKRTDELGYFAFGGSTLVAIWPPNSIQFDKDLLMNAQEPLETLTRVGQHIGKAVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWB6</accession>
    <name>A0A8H7PWB6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="13">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_008600</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Polyol metabolism; glycerol degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="13"/>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWB6"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.870:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000037">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="5 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="673"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2181018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="768" mass="85618" checksum="993DA05A94188331" modified="2022-01-19" version="1">MWRRLSRSQKLLVSATSVTGVGGAYLFYTEAQRTRQRHAQYMATLNGLPVAHAESLQAHAGIIETDIKPHDFWAPPSRQEMLNKLKGLDKDGQKSAKPEEFDLLVVGGGATGAGVALDATTRGLKVAMVERDDFASGTSSRSTKLVHGGVRYLQKAIQELDYEQYKLVVEALHERKIFLDIAPYLSHQLPIMLPVYKWWQVPYYWIGCKMYDWFAGGEALESSYVLTGSKALEAFPMLKKDELVGALVYYDGQHNDARMNVALALTAVNHGATVANHCEVKSLTKDENGIVNGAVLHDVFTGDEWTVKAKGVINATGPFTDGLRKMDDKENNEIVAPSAGVHIILPNYYSPGNMGLLDPATSDGRVIFFLPWQGNTIAGTTDSPTEVTQNPLPKEEEIQWILNEVEHYLSPDVKVRRGDVLAAWSGIRPLVRDPNATKTEALVRNHMIHVSENKLLTIAGGKWTTYRAMAEETVDRAIKEFDLKPTHSECRTEVIRLIGSHAYSKTMFIKLIQHFGMETEVAQHLANSYGDRAWDVGTMADATHQRWPVFGKRLSPQYPYIEAEVRYAVRREYACTVVDVIGRRTRIAFLNAQAALESLPRVIEIMSTELSWSKERQKKEFDDAIEFLITMGLPSGSSQIIYPVTKDEHPAGAPIENVKSHDSVFSRARFLPDELKEFQQVFSELDKDKDGHLNASDLPKVFSKLGVSVKDDVLKAAVKALDSNNNADSVEFSEFLEIMSQVKDIEIRRHLTTEKGGKISTERSGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXH2</accession>
    <name>A0A8H7PXH2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dual-specificity kinase</fullName>
            <ecNumber evidence="3">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">INT43_007359</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXH2"/>
    <dbReference type="OrthoDB" id="283111at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000002">
        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000612">
        <property type="entry name" value="Serine/threonine-protein kinase AFC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="195"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="754"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="754"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="782"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG2182429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="801" mass="91883" checksum="804BDDD97DE35708" modified="2022-01-19" version="1">MTTVATRRRKRSSNTDWKQDFYRNGYPTEVIVIEDSPTPAPDQQSSNGSTSNGQQQNHVQPYAAPPAASTRSKRPRRKATTSTYQQPAPQPAQLGYPVLTPVTSLVGNFAQPAAKRRRKENGDASVYADSKSFFIVHSVLYWLRTNLCAFDIITAAVRQEPIYRPVSNTETFSANYDDKDGHYIIIPNEDLTTRYKMIRLLGQGTFGKVVECWDRVRRRYCAVKVIRAVPKYRDASKIEIRVLNTLKENDPLNLNKCIHLLEWFDFRNHICMVFELLGQSVFDFLKENEFHPFPPHHIQHFAKQLLTSVAFVHDLKLIHTDLKPENILLANNEYRLVPCRPTKRSGSKVQRLLVNTEIRLIDFGSATFEHDYHSSVVSTRHYRAPEIILGMGWSYPCDIWSIGCILVEFFTGDALFQTHDNLEHLAMMEVVLGKLPERTLRQAKHSQKYFENGRLHYPNEETTKQSRKYVKAMHPLQEIIPPSSNLNRQLLELLQKLLMYDPADRISAHEALKHPFFHVQLDEHGREIKGKTDYYARKRLVVQAKNKYNSPKYRLVVRFTNKDIICQIVYAKLQGDHVLTAAYSHELPRYGIKGGLTNWAAAYATGLLVARRTLTKLGLADKYEGVTEPDGTVEMTEAIEDGPRPFKAFLDVGLKRTSTGSRLFGAVKGASDGGIFIPHGENRFPGFDIESKSLDNELLRNYIYGIHVAEYMEYLQDEDEERFKKQFAGFLANDISADDVEDMYTEAHAAIREDPSAQITEKKKPAAGEKVKAYRKQRLNKKQRDNKVLQKKTAWEKKNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXP6</accession>
    <name>A0A8H7PXP6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="7">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_006962</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HDDC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="7"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXP6"/>
    <dbReference type="OrthoDB" id="10254258at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000016">
        <property type="entry name" value="HD domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="10">
        <location>
            <begin position="36"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2182036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="187" mass="21236" checksum="0660D7B0BACA8ED5" modified="2022-01-19" version="1" fragment="single">MSNPTNVIKFLHIIENLKRTKRTGWVDSGIQKPESIADHMHRMGVMAMLIDDPTLDREKCIKMAIVHDLAEAVVGDITPHAGVSKDEKYRQERTAIESYQSLLGDSNMAKEITSLWQEYEDAATPEALLVKDLDKFEMIVQALEYEKSDKKELQSFFNSTNGKFKHPTVKAWAEALYAERNAHLGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXP7</accession>
    <name>A0A8H7PXP7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_007105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXP7"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2182178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="231" mass="24113" checksum="04FC0566E403C53B" modified="2022-01-19" version="1" fragment="single">MFLTIFGIQAARGDSATMSGVRIIVGQAAITVTSSIGGYLMGRFNTYKPIITIGTSLAALGIGLLALFTSTSPFGEMYGFLIVAGSGAGMVYACSTVAAQSACEKHELAVVTVLVNFFMNLGSAVGIAVASAIVNNGLQSCLGDHLSADLVTSILQSTTFIRSGVLSPEQQDITITCYVSSFKTAWTVMAGFAAIAVVASLFIKQHSLFRDRKDPSKSDQSEVIVDETAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PY27</accession>
    <name>A0A8H7PY27_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_007303</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PY27"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="25"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2182373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="448" mass="50276" checksum="F1393B6967960502" modified="2022-01-19" version="1">MTSRTASDTFDPSQRIGTFIDDDRLEIVGLLGLGAYGAVYLGRHILTRKHYAVKCLNRIGLTKRQHGFQQREIALHQMLSDHPNILTLEKVIHTPECIYMILEYSREGDLFNAITETNFYAGNDRAIRRVFLQIIDAVMYCHHYGVYHRDLKPENILVFEGGTRVKLADFGLATTEEYSSDFGCGSTFYFSPECQGGIHKNTKPYKSAPNDIWSLGVILINLTAGRNPWKQANVKDETFNTYLQDPDFLLSILPITTELNEIVKRIFCVNPEKRIRLHELRRRIASCRHFTRLAISHESPTIPLAIPDARPCNKPRTPPQSPTSIEKQVASPLSLEMPVTPASSYSLEEDVKPTTDSCVTFSTLSSSSWQSVGTEVSTAAETPTAAFNAKCRITPSASSRCALNTPKDELLPSMQTGTVLSDRRYEQHRNVDHPHVAESVVISSFSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PY42</accession>
    <name>A0A8H7PY42_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell differentiation protein rcd1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PY42"/>
    <dbReference type="OrthoDB" id="1183224at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000014">
        <property type="entry name" value="Cell differentiation protein RCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2182402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="39447" checksum="F0561BA872F5729A" modified="2022-01-19" version="1">MQPVLSSSQGLLANALQSGSGSGMRYNAMMQHQLQHNNMPTADRRYEHSGYQNAMHSNQSAALQQQTKQLNSEQMSQRSIQAEDKIYALVLDLMNPELREQALLELSKKRELYDDLALVLWHSYGAVSILLQEIISVYPLLSPPALTAVASNRVCNALALFQCIASHNATRTHLLNAHIPLFLYPLLNTTSKTRAFEYLRLTSLGVIGALVKNDNPEVINFLLSTEIIPLCLRIMESGSELSRTVAIFIVQKILMDDTGLVYICQTYERFYAVTTVLNNMTAQLAETQTIRLLKHVIRCYLRLADNPRAREALRQCLPDQLRDNTFAPILKDDITTQRCLSQLLINLSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PY59</accession>
    <name>A0A8H7PY59_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 13">Catalase</fullName>
            <ecNumber evidence="3 10 13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">INT43_007463</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 13">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 13"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PY59"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000003">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF1">
        <property type="entry name" value="CATALASE-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="16">
        <location>
            <begin position="48"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2182532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="758" mass="85238" checksum="EE680563FB7E0668" modified="2022-01-19" version="1">MTDLVNKMSSMKDNMAEASATKPGSSKKDQFLEKAYRTQDNEPGHFIATPTGVKIDHTDDSLKAGERGPTLMEDFHFRYTMTQFDHERIPERVVHARGSGAHGYFELFESQSDITKAGVLTDTSRKTPVFVRFSTVQGSRGSADTVRDVRGFAVKFYTEEGNWDLVGNNIPVFFIQDAIKFPDLVHSLKPEPHNEIPQGQTAHDNFWDFASLMPESTHMLMWILSDRTIPRSYRMMQGFGVNTYILVNEKGERRFVKFHWKPLLGTHSLVWDESLKLAGQDPDFHRRDLWEAIESGNYPQWDFGLQVIDEKDEDSFDFDLLDCTKVIPEELVPVKWIGRMTLDRNPDNFFAETEQVAYCTQHVVPGIGFSNDPMLQGRNFSYLDTQLNRFNGPNFNEVPINQPVCPFFNNLRDGFNRQRINKGKTNYYPNRHMNPKPATAEEGAFVHFPEKTEGMKIRTRGSKFREHYNQAKLFYYSMTPVEQQHIIDAASFELGRVDDQQIQVRMIEGFLKVDYTFAKAVADNLGLEVPQASGNDAYNGKLSPALSQLVAPVQSIATRKIAFVVVDGYDKAQVLSLRGAIKAAGAMTLIVGPRRGVVKSQDQLNSSKESSSTVKVDEEGISADFSVLTARSTLFDAIVLIGTQQALEQSGQRGQIIHFVNEAYKHCKAVGLVGGAVEFARKYCSIPQTALSTDNTVCCEDGVVTVAQWTEATEESSFAKQTVEAVKSIGKTTNFSKSFIDAVSQHRFWNRDVSSVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZ60</accession>
    <name>A0A8H7PZ60_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4-nitrophenylphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_007046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZ60"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2182119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="39266" checksum="9A0E5BA5C4F77721" modified="2022-01-19" version="1">MIPQLQRNFDSSASMFEDSIHPHASEVAQSDYSMSTESSVATPIGTPIVTPGNEYKLSTFESNFPPSSAVLKDHALLTDEKLHVQRLNQIRNKKAYIIDMDGGSKLLPGAKEFVQFLKDNNKKFLFLTNNSAPTPRELKQKLGRLGIDVDEDKFYTAGMATATFLKSQLPEGGTCYVIGEPGLTFALYSEGFYMNDVNPDYVVLGEGPSYDYEKISKAVNLVNRGAKLIATNLDTDCLNSKGESIPSCGAFAAAIELVTKKKAFFCGKPSALIMRYAQKALEAELEDTCIIGDRMDTDIIAGITSSIDPVLVLSGVTKMEELSDWSYRPYVVLGGVFEIPTLNVNSLTNEANAKETMAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZL3</accession>
    <name>A0A8H7PZL3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZL3"/>
    <dbReference type="OrthoDB" id="7457040at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="101"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2183168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="415" mass="47261" checksum="553572D62F4C57F9" modified="2022-01-19" version="1">MTDIKQDTISSTLPAVIPPTSHMNFLKSWWKRSDKTSEIAEIRLLKRYISSNVTARVGRVDIGGNNRLINTLVVEKANQNDPNRGEVLNGSIPTHNNDKKALVMCHGYGAGLGFFYRNYNDLAEKSPNYRLYAIDWLGMGRSSRPKWEILRKKDETWDNVVEETESHFVQCLEDWREAQKIDKMTLMGHSLGGYMATCYALKHPERVEKLILVSPVGVPVNPNNAPQEEKPEVALPKEAAQLGKAMEAEATEREFDTQTEPVRVPRRIPSWAAYLWDKNVTPMSIVRLGGPLGASLVNRYTSRRFAHLDEDEQHSLYDYLYHITSSTGSGEYALASVLSPGAFARKPLIHRMPELKMPTVFIYGVNDWMEYKPAETVSKKMNVYTKIYRISDGGHHMYLDNHVEFNQAVLDELKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q010</accession>
    <name>A0A8H7Q010_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanylyl cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_007163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q010"/>
    <dbReference type="OrthoDB" id="206796at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018616">
        <property type="entry name" value="GUCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31400">
        <property type="entry name" value="GUANYLYL CYCLASE DOMAIN CONTAINING PROTEIN 1 GUCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31400:SF1">
        <property type="entry name" value="PROTEIN GUCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09778">
        <property type="entry name" value="Guanylate_cyc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2182236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="27686" checksum="E1A64AC7930AD1AD" modified="2022-01-19" version="1">MAYEELSNDSKLVNYSRYDESIVPHVMQNSNWDCGIACIAMTLQALGKNIDLDDLRQQVHVNSVWTIDLAFLLRNYVEDFTYYTSFLGSRKEYQSNKFYQDNFSEDEKRVNKLFAIAKSCNVHVVRMLLPIDDFKRFLFCKKFAIITLVNARLLRCQICQEQKGCSASMCVGFDSILERMKGYEYIGHFITLINYDPNEDAFIYRDPAQQDKICVISADTFDAARQSIGTDNDCIVIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q073</accession>
    <name>A0A8H7Q073_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EXPERA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_006548</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q073"/>
    <dbReference type="OrthoDB" id="58557at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF1">
        <property type="entry name" value="EMOPAMIL-BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="8">
        <location>
            <begin position="42"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2183542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="209" mass="23717" checksum="79AEC1EC6B2AC6AC" modified="2022-01-19" version="1">MSASTDDLFTTTTIVSLLGVVAILAAAYGASVFLLPKSARSVDRYIFVWLGFDALIHFIFEGSFLYHSTFGRAVFRESGPFAELWKEYAKADIRWGLADPTVVSLEILTVFGAGPLCVFLMYQIIKNDPARYYNYIVLSVAELYGGWMTFCPEWLTGSAFLVTDNWFHHLVYLWFFNGIWVVIPAYLLYHSYMEIVLPLRAQLKGSKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0C8</accession>
    <name>A0A8H7Q0C8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NLE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_006209</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0C8"/>
    <dbReference type="OrthoDB" id="10267436at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000464">
        <property type="entry name" value="Ribosome assembly protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="6">
        <location>
            <begin position="22"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="114"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="163"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="206"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="253"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="372"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="414"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="456"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2183205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="489" mass="54393" checksum="FC223924A6B30885" modified="2022-01-19" version="1">MAARQRKKAAEAIEQIPEGQNVIAQFKSVDGESTGPPLNLPVNVTPDQLEMLLNQLMNTSDDPQPYSFLVEDAEITKNLWTDMKSKSTEENITIVYQPQAVFKVRAVTRCSSTLSGHTEAILSVAFSPDGTQLATGSGDTTVRIWDLNTETPQHTLKGQYHHSERHKNWVLYIAWSPDGKTLASGSMDNTVRLWDPKTGKAIGDALRGHTKWITCLAWEPYHLNSKANRLASSSKDHTVRVWDTALRRVVFTISQHTAAVTCVKWGGEGLIYTASQDKTIKVWNSSGVLVKTLQGHGHWVNTLALSTDFVLRTGPYDHTGKRYKSEEEGKAAALERYNAAKGNQPERLVSGSDDFTMFFWEPEANKKPLARLTGHQKLVNHVSFSPDGRLIASAAFDNSVKLWDGRTGKFISSLRGHVGPVYQVCWSSDSRMLISSSKDTTLKIWDLKTKKIKLDLPGHLDEVFSVDWSPGGDKVASGGKDKQLKVWRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0Q3</accession>
    <name>A0A8H7Q0Q3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_006242</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0Q3"/>
    <dbReference type="OrthoDB" id="2155291at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF17">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN RGD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="4">
        <location>
            <begin position="5"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="502"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="776"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="842"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="854"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2183238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="906" mass="101018" checksum="5C7C7BDCAB789522" modified="2022-01-19" version="1">MSQALHFESSFWSQKFTGTNVPEYQQGLRILHDKLAQSKTENDEVIAFLRERVSLEESYAVKLTDQGQQRQKSRGFLRDEGATLKKGFDSLRAASELLGSQHMELALNIHDVVLKPLLKMNDEYKTEVSSAKRNIDMKFKQFDNSVKDMDRLKNYYIRKCRDADRAEEQAVLIASETAKNIASQDKTESSDSSIQDTDEKEEQSEDPQGQRNEAETTSPALETEKQETFTLAGQVYSASEFEGLIAKMRQEIPVGEHKIAIFGTYQNTSTGENIARWLQQNVPVCKDSPAAADLIGQQLISAYHVFKLIGQLGDKFVPSSSSIYQWKTIQTSPEIATNGYATSALEGVSGFFGKFGNTISSNASTIPGLPNSGVPGEEPYKIARQEAVQADVAYEKSVRKLDNVRLQLEQLLFAHFSEMEQLEIDRISTIKRAFIEFGALMSNTLPTSKAIYEQMLLYQQTLKPDQDIQYIIQQYFVSGFAPKAVLYENFYHGHALDQSFGVSLIDDSKTSETGIPKIVQLFLNALEEKTKNMSLPDVMAVWATPVALDKVHIVRNELNVPIDQLNDNTMETYDPALLAGTLRLYLRELPESVVTSELYEAIKSLYTDSKLIMSPSDNQEEAVRVQAVAKLLTTMPKAHYTTLKALMGHFDSKLKGSANNKEQPHEVGGSNDFLTKIGQAFGSLLLWPRYATYTTTMDRHLAHLVRDFLSHYDTIFSEDMTVSNTESEKRRLETTIVTDKLGNYQGTVPEPTSPSRRRGLMSLDAAKQGASSMFGAFNRASSSDPPPLPPKNSGSTSSNPLGLVSPPTPSKTPDAFVIADEQTMTPGLDGNEEPDVMFDATEEQEKQITMPSTKPEELSKLATEEEMGLSDQAGKQYSSAQRIEEIDDVVPKDKDGNDIDPFFEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1K0</accession>
    <name>A0A8H7Q1K0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">YrhK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1K0"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2184724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="47514" checksum="732D5308462C9D13" modified="2022-01-19" version="1">MSGNNSTDGGDNSTDGGDNSTDGGSPTPTTQHDKPTEKFQEINGVLFPSDWQVVEKSKVGPFIVGVDFKQPNGRVFRWSNRRHRKGRAWVHNGEHELHAGKKKTPEEVVATRKPLWPLSVRVPVDAKFRYFGWEPRNIVWCYGWAFTLGSILFVIGGVPSLMSTVINDTDETMRLVNIPFVIGASFFLVGAYVAHFNVLNLDEVAKAETWEDYRLSHGIDIDLEADGVPMHVDGRSAPSKAMELPSDTKDSDRPRPRHKYNITAHAAKHHFFTNPPQSATRRFVGFKPTDLGYWGTWCLTVGASLFLINSSTVFCPLVTPGSLLEKMVDFLFSTVASVLFVIGSYLKFAEVGESWNPFAIRRDQLYFYDVWGNLIGSIAFLVASILGFIYPGIPRDIGTNTWYFIGSVAFLFASPFKIIESLNSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1T8</accession>
    <name>A0A8H7Q1T8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_000787</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1T8"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF0">
        <property type="entry name" value="YIP1D-INTERACTING FACTOR 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2184874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="340" mass="38084" checksum="A8E787845F35A227" modified="2022-01-19" version="1">MYQPNAYQQQQGYDPNSYTPSPQNQKGHGSTFANSRSPPPLQHPVPQHPILNFRADAASPSPQMSHQQPQGNMNYYPQQQAGNAYPQQNSNIYSQFGFNDPAAQMGMQFAGNAMAQGTAYVEQNLNRWVNIPAVKHYFNVNNLYVINKMRILLFPWRHSPWTRMARRSDTGQMEGYAAPREDINSPDLYIPVMAFVTYVLLCGLAAGRKGSFHPEVLGFTASASLAIVFTEVLLIRLGVYLLSIPSDTSVLDLVAYSGYKFVGVIVTTAMKQLGFGGWAVYGVFLYTALSCGFFLLRSMRYLALPDAGNASTMNPQRKRRMWFLLMIAASQLLFMFVLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q279</accession>
    <name>A0A8H7Q279_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent bile acid permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_000486</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="586"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="993"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1076"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1157"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1181"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1269"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="341"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="679"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="996"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1357"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2184577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1614" mass="181089" checksum="338381BA7A302099" modified="2022-01-19" version="1">MLSSNVRKVSTCACSALQVKLTWCSWLVSSVIDAGVTGTVAVVSAIVLFAAVTRHYRRQNSGYQPLKSTPSTSYGAVDSSSQHSSVIEEEEDYAESEDTLVTSLDNHKSFTIFDATRFLAMLLAGFSLYNLVSVINNHYDSDSRVESNKLALIIQYTTGTLVWIYATVLAFINVAMSRTNALAAYGVRRHLNLIYFITFLVSMVDARSFYIVRYTDIQTSGYLYALDTFFVTFALLLVIINERFGAPTTTIITKSVSFSPKILGRPLSTEAWASMYSQFMFTWLNPMMKEGYRKTLNDTDLLELPPFNRAPNILRSYRKNKRARMLFGLFHTFRHELFKQVFFAMGWSIFLFGPPYFLNKIIKSIENPATEGSGYSLTPFLFVLGLFITSCTQSLLLQQALYIGRTLGIRIQAIVIGEVYAKALKRRDNSGASEDSVKKDDSKDDNVKDGKKDEKNDDKVHGNINNLLSVDAQKVAELAAYIFYLYTHPLQIIFCIWGLYRLLGYAAFFGVIVIIVTFPLPHYLTKKFESNHKSVMAATDSRLKIMNELLGAIRIVKFFAWEKEFKKRVEEARTTELKCIRGRLMIYMWSGNVWFLIPILIMVTVFYVYTLGHELSASTAFTTVALFQNLRGALDELPFIISFLFQAKVSLERIDTFLGEDEVEESKHVRKDGNNFIGFRDNATFKWFGKPTSSASGTDSPVRQVQFTLKDLNLSFPPNKLSIVCGPTGSGKTTLLSSLLGETACVSGSAVLPRNGFKASNPIGGAVSGIAYVAQSAWLQNSSIKDNILFGLPFDEDRYEKVLYMCALTRDLEILEHGDATEVGEKGITLSGGQKQRLAIARAVYSQATVIVLDDCLSAVDAHTAKHLYENCLMGDLMQNRTRILVTHHVGLCLKGADYIVALQNGEVAGAGHPMDLVKTGVLGEELANMEEEVAEADEAAAVEGKVPELPKTVGKKARKDGDGKLTQDEVRAEGSVSLTVWKTYFDASGGTFFWLAVLFMFCVAQFMIIGQDYWIKVWAGAYNSVNGTMSDFAILTTGGQYRDFISMEMNTPNYFHQLMHSAGNLKTTVPQHVDVNYYLGIYFLIGVVTMIFASLRNYILYMGSLEASKKIHNTLINRILRAKVRFFDVTPLGRIINRFSSDMETIDQNVAPSGSFLLNSIVATVFVVLLISWVTPLFLIPGFVIAAIFWFIGTFYLESSRDMKRLNSVSRSPIYVQFNESVNGVATIRAFGAQSRFVRENMTKIDSNNRPFIWMWATNRWLHCRVDILGAFVGFCTGFVIILGRSWIDPGMAGLSLSYALTFTHNVLWVVRMYAVNEMNLNAIERVQEYLDVEEEPAAVIEEARPRDSWPETGSIEVENLVMQYTPENPPVLRDLSFSVKPREKIGIVGRTGSGKSTFALSLFRFMEPTNGSIKIDGIDISKIGLEDLRSRLTIIPQDPVLFSGTLRSNLDPFSYCTDEELWAALKRSHLVDENDEPNEVISLDSPVTENGSNWSQGQRQLIALARALVKKTSLIILDEATSSVDFDTDHKIQQTIRSEFKESALLCIAHRIRTVADYDRILVLDHGRLLEFDHPYTLMTKEDGVFMQMCQRSGEYNELLSIAKAKWESDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2A5</accession>
    <name>A0A8H7Q2A5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2A5"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF11">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="392" mass="43354" checksum="04BB09E177179AEB" modified="2022-01-19" version="1">MPATELKNIVVIGGSSAGIASALNWRDDPISSHRMIIVEQKSHYNYVYAFPRASVKPGIERELFVPYANLFYSNKNIGQVVQAKVIAIHPNYIELDRSVEDFGKSIPFTHLIFATGTTIPAPGHFNADSKADGVACLKTYQDLIRQSKKPLIIGGGAVGLELAAEIKDFYPEKDVTLIHSRERYLQVYKSSLHTLTFGLLKNKLGVNQILGDRVVVPKGGFSLEVKPITVRTTKGRTIETDLPITCIGMTPNTNLMAELSPQTLNLHTRFIQVKSTMQIKDDRYPHIYAAGDVIESTDVKTGHFAWYQSLAALHNIRLQINADSELQPYVSKGVAIIKIALGDKKAVMQTNVFGPLITLPSWIVGGSVPDNLYADFPWAWIGLPCDEEHKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2X7</accession>
    <name>A0A8H7Q2X7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_000880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2X7"/>
    <dbReference type="OrthoDB" id="10253709at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005371">
        <property type="term" value="F:tricarboxylate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015742">
        <property type="term" value="P:alpha-ketoglutarate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000078">
        <property type="entry name" value="Mitochondrial DNA replication protein YHM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053017">
        <property type="entry name" value="Mito_Cit/Oxoglu_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982">
        <property type="entry name" value="CITRATE/OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982:SF1">
        <property type="entry name" value="CITRATE_OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="20"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="213"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2184967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="32881" checksum="FD96AA4D0FF0EFD6" modified="2022-01-19" version="1">MAIIDTTPVDPTAPPKKKAVSYTNLALGAGLNMFEVSTLGQPFEVLKTQLAANRGQSMAAALRSIYSRGGVLGFYQGLIPWAWIEASTKGAVLLFTASECEYRAKAAGASPFLAGIVGGMGGGIAQAYTTMGFCTFMKTVEVTRHKSAGNVSTWAVANDIFKREGIAGINKGVNAVALRQCTNWASRFGLSRYAQESIIKYRYGSDPDAHKRATVMDRALASIIGGGLSCWNQPIEVIRVEMQSQVKSEGRPTKMTISTAAKWIYQNNGMTGFYRGVVPRIGLGIWQTLVMVTAGDYFRAKYKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q478</accession>
    <name>A0A8H7Q478_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_000923</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q478"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12122">
        <property type="entry name" value="AMPKA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14334">
        <property type="entry name" value="UBA_SNF1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000544">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000236">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013896">
        <property type="entry name" value="SNF1_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08587">
        <property type="entry name" value="UBA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="14"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="390"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2185010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="611" mass="69045" checksum="891539DE707190F5" modified="2022-01-19" version="1">MSSTNGNRMRIGQYNLIKSIGVGSFGKVKLAVHSITGQKVALKIINRKKIASLDMAGRVKREIQYLKLLRHPHIIKLYEVIVTPTDIIMVIEYAGGELFNYIVEKGKMGEDDARRFFQQIICAVEYCHRHKIVHRDLKPENLLLDDNNNVKIADFGLSNIMTDGDFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYVMLCGRLPFDDEYIPTLFKKINGKYQPLDGFTDGGIYTTPSFLSPETKYLLTSMLVVDPLKRITIQEIRQNPWFNVGLPEYLRPLPDTAETLDQEIDEDILSELCKKMGYGRETIYKALSEPDNNQIKVAYQLVVDHHRMIKESENISKENNISSFFATSPPPWNSQLEEKSNEQQYDGYNLETPSSISVLSSSLPKGDDNMRAQNRSTYAGQPIVPMSGTPPPGSKSPTLSKSSHRNPVLNRQLSTSTPASKRQHKARSKWHFGIRSRCPPWEVMLEIFKSLKNVGFEWKVLDPYHLRCRYQYPSGIIVKVDLQLYKLDVNSYLVDFKSLGQVMAEGYCPQVSPNTSNVSSDDMQLSDKFSDDFSYENTIRQVTFLSEQADASNESVLSTFPFLDVCSKLITELAISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4J5</accession>
    <name>A0A8H7Q4J5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4J5"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="81"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2186374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="318" mass="34718" checksum="016AD45ED59B9226" modified="2022-01-19" version="1">MSFKPQLEPHTQKFIDSLAGSTPIETLPPNEARNVLAGAQKSVAYNLPAAVEEVNFPVGPTGKVLVKIVRPENASGTLHPILYMHGGGWILGDREVFDRHARAMATGANAAVFFVEYDRSPEAKYPTAIEQGYAVGEYISNNAQKFNVDASKLVVAGDSVGGNMTGAISLMAKERGGFKITLTVQFYPVTSAKLDTESYKTYAGGPWLTKPMMEWFWNAYAPEASQREAHTASLLNATTDQLKGLPEALIITAENDVLRDEGEEYGRRLAQAGVRVTQTRYLSTIHDFVLLNPIYETPAARGATAQACQHIRAHFSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4N8</accession>
    <name>A0A8H7Q4N8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_002191</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4N8"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391">
        <property type="entry name" value="RETINOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391:SF5">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2185756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="36056" checksum="6A9B139CD0F86A23" modified="2022-01-19" version="1">MVLQQNKLLAPWLALLTIFHTSTFVLPASIIALAWEILNYVSGRSGRLLAAKPTPKNIVITGAASGIGENVAVRYASDAKYAKGSLKLILMDLNAERLAKVAEDCEALGAKVETKSIDVTDADAMNDYLLDVDDRVGGIDLIWANAGVVATMAGKMNAEGRREGTLKEKLDLVIKVNGMGVLNTITPLLDRFKERKRGHLAITASLASFFIFPQVTGYSVSKRMVYRLGRDLSVVLKPYGIDVSVICPGFINTPLVQDATKHLPKNRQPPMQLNVNAAGKTIKRALDERQEVMMFPLPTVIGSYTMNITQDWLANWIWSKANVTWENSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4N9</accession>
    <name>A0A8H7Q4N9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cell division control protein 42 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_000534</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Lipid-anchor</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4N9"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000236">
        <property type="entry name" value="Cell division control protein 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2184621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21199" checksum="46B14458D8DB2AFD" modified="2022-01-19" version="1">MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGDEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVTSPASFENVKEKWFPEVHHHCPGVPCLIVGTQVDLRDDPNMLQKLARQKQKPIPFEAGERLARELGAVKYAECSALTQKGLKNVFDEAIVAALEPTPKPKKRGCNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4R3</accession>
    <name>A0A8H7Q4R3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4R3"/>
    <dbReference type="OrthoDB" id="2189463at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052636">
        <property type="entry name" value="UDP-D-xylose:L-fucose_XylT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47032">
        <property type="entry name" value="UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47032:SF1">
        <property type="entry name" value="UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="2">
        <location>
            <begin position="147"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2185927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="364" mass="41827" checksum="F67C3CF863A53F16" modified="2022-01-19" version="1">MERPNKKLQTVLLLLIFAFVGFVAYMNFSSSLGNGSYLEKFTADHVEATIDTTESSPEASSATYPPASEQDADLEKILPNEATFKDEMYGDLVWQAKAYAQPAQNVLDAIENNYIEPSEKTLLIAVVNHGMMEYILNWIESLRRSEITKYLVFAIDQDLVDAMTEAGLGDHVVLIPDDWRHVQLSGDFAKWKSNDYTPITHAKSLIVERLLYLDVTVWFSDVDIVFTSPHIYTHLMWNLKSRVHVDMVFSQETVQTSINSGFYIMRPTETSKRVIGRTIDIQDRIPKLTQQRVMNRVLGGMNQDYRQSPMILLDEMLFPNGHFYFDAHLPTKLGFEPMMVHANYRVGDKKKEALQEYGLWYLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5A5</accession>
    <name>A0A8H7Q5A5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5A5"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF64">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2186227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="50185" checksum="F50BEE050D42934F" modified="2022-01-19" version="1">MVETHIVYPTNKYNRPAVPDAIKLHDLDLFSAPIQIVNHRFFHPSDRSISEIVEKLISSLAEALELYPPVAGVVHTLDNGDICIITKPEDDQGTPLLVDIKDTSYTTDSEDLSPRVGLILSPDASTFAAKITQFSCGTICVASSIHHQVTDLRGFLDFLEVWAQIARGEPIDLSKIPNDWSRNPGQYFSGLLNESTVPPVPMPFDLLDEPATEPPAFLMQPSKITDWSISKDSMERMKKAFSPTDSKDLWISSGDALATLLCGAVTRARESANVPRLEGRSPLNLDTEKLAMAADGRDRAPKGDMSGKYYGNFNNLPGVNVSRSDLLSLTNESASRVAVAIRRALNDQLTPLAIAKRIAFYESPEVNTPPGRIVFTADVILTNWCRFDLQGPKLDFGWGKAFLATSGGGSIYPPGYSIMTQNKETGETSIMLTIEEAALEALKADELMNKYATLVPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5M2</accession>
    <name>A0A8H7Q5M2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_002845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5M2"/>
    <dbReference type="OrthoDB" id="860at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF93">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN 25D9-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2186407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="21866" checksum="3DCB46314B56409C" modified="2022-01-19" version="1">MSAPAKPSLLTLYLTELAAHPLRTKAITSSVLAGLQEFTAQKLSGAKSPNQSGPVDKRVVQMAAYGFLVSGPLNHVLYDILNRVFAGKTGPKAKLLQLLASNLIISPIFNCVYLSAMAIIAGARQPHQIVNAVKNGWFRMQKVSWVISPITMTFAQNFLPPHTWVPFFNLVAFVFGTYMNTMIKKRQIKAAEEAHGKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q661</accession>
    <name>A0A8H7Q661_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002436</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q661"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140096">
        <property type="term" value="F:catalytic activity, acting on a protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990444">
        <property type="term" value="F:F-box domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062026">
        <property type="term" value="P:negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070372">
        <property type="term" value="P:regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052449">
        <property type="entry name" value="STYX-Interacting_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588">
        <property type="entry name" value="SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588:SF1">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="39"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="107"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="302"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="195"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="460"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="515"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2185998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="527" mass="59947" checksum="CA68FE21A62A24AF" modified="2022-01-19" version="1">MESVIHSLNDGQLAENDPLMVQGGSTSNLDDWRYEMRREVQEILPNIFLGPFSACRDMTSLAAKGITHIVCFFDCHEAALFKTKKLESIFQLTCIEVSDSPLQNLIPQFPTATKLFNNALSAGGKVLACCIGGMSRSPTFVIAYIMETFRVDFIRAYHFVQGKRLCINPNEGFKSQLKEYEPIYSAWSFRGSNTAEEINRQTSRRRPAPDDDDEPEDIRRHPRVDSHISEDHDRASAVSPHSIATLRPDSNLTAQRRSYLSMLDSQQAAFDRFKESSHRREERDHSQKRARLASDMSLPKLNSVHQGRVVKIMEFGAFIQMVDVIQQGLVHKAQLSTHRVEEVADVVQMDDPVWVKVVSIDEDDSGKVKIGLSMKYVNQGNGDDMDSGNVNYGREQENRKKGQIASTFNRPPIELTDAVMMNVVCKKCGGKGHLPTECFNAPGENYELIPEEDEIDYDLREESSRAKKDKKHKKHKKRKRESSRSASPPGARSVNSMADALSVMRRRARKDDKKSHHHHRHREHRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6G5</accession>
    <name>A0A8H7Q6G5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_002633</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6G5"/>
    <dbReference type="OrthoDB" id="19996at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039725">
        <property type="entry name" value="CC2D1A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006608">
        <property type="entry name" value="CC2D1A/B_DM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13076">
        <property type="entry name" value="COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13076:SF9">
        <property type="entry name" value="COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00685">
        <property type="entry name" value="DM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="166"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="862"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="862"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2186195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1052" mass="116234" checksum="8CCD0F727D9CC3F9" modified="2022-01-19" version="1">MFSWKKSTNEQPRTASSSNRSGGVDNMDFSDLLKDPVDATGDGTYDDDMDPDLLKQLQELSTSSASAKAKPKRAVPQQPAIDQMDLDAYARLAQDEDIEVEFDENDLNDPNLLRELSMIGESGPNVIEEPTTITKPLPPTVTEEIPSMSLKKLPMNDSHKTARSLPPNEEALQLMAMGFSQRQAMDALKFSDNDLERATNYLLDTPGPAEEDENLQTSQSNDIQSSTPVNTEYNQLVDTSANMMDNDQYTNPKVSMEPLQPTTEYKRLDGPHTDPDSPTIQKTIPAPTQTTYDNVQYEPERSSKPESTDSKDIGSEWDFEEKYNETDIIILAQYATDYQKAAVAAKRAGDKSSAIDLLRKSKLFTAKKEELKELQSDTTFGEADSHHTNVQAQDISTPPQRVSPSLESLAQKSPAQQSPLQDSQPVEAATQQGKKSPQQPSSDVVDEQRAAEVEQQDKVPAMNSEIPSEGARSPAVAPPTSSNNIRQSSPQPAIAPEHAEIQQLLEALITRQKEYKVAAIHYKEIGNLAVAKEMIRISKDVLQTAVAVKNGQLTSVQTIKNKLPKAPDMELGSGKPRQPQEVNVMDHRGNLPSFEQLQRTLNYQMDICHNLELQSRGNQGPGNNNLGNDFKELAKTFAADLASVKSAESSNGSLPRFHYQNVSYAYRETNSEISSNEMIVHVKKAMQLQSLEASAQNIEAYVQWDLGGWPPESVPQAHLGKGQTPSAAKGGNPDFDFKTSIPIARQNRAFMRYLQRKKATFEVYHKRYSYGLFARPLLLGKVTLEMNSLLHTATAGGVLELLDQNRKKTGGLLHVNICLSEPLLNDDVPVKQEKWLIIDEYNANIYSLLASARLVPQSMANYQPAPASSPQALTPPSIQSPAPSPVVAEQVPKPDQSPPAKIAEENAPPTAPKAEKSEEENELDKAEADLNKYYFKSVDSIVSNMVLENEIGLVNSAIAACHGTVPDDLMDQKQALEIKMNMLVIQVQTGLLTMEQYLANVEARMEQDKKCALIFKRAGRLDLAKKALRRKKIAQEEVEEAKAAMAEQAEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6G6</accession>
    <name>A0A8H7Q6G6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_002397</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6G6"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10429">
        <property type="entry name" value="GAAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2185959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="252" mass="28483" checksum="44B49064FF7316D6" modified="2022-01-19" version="1">MSYGARNYTAPPPAYDSEAQEPLMGQTGDDMFKETVANSSMEIRMQFVRKVYSILTAQILSTCVMSAIFMYNTSAKSWVQSNIWALYTSMFATFGVLLLLFWKSRSAPLNYYLLAGFTLAEGYMVGTVVTFYEQTLVLQALIITCGVFLALTLFTLQSKWDFSGMGPILFASLWVLILVGFVQIFFPFSEGIQLAIAFAGVIIFSGYVIFDTYLIFNRYSPEDYILASVSLYMDFINLFLRILQILSAMNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q769</accession>
    <name>A0A8H7Q769_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_002817</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q769"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2186379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="338" mass="37527" checksum="A45A035D358C1451" modified="2022-01-19" version="1">MSGKLVLVTGPSGYVGAHVFQTLLEKGYNVRGTVRSDEKANQLKEDFAKYKSQIESFVIVEDIAKDGVFEDAVKGVDYIIHVASPFHFDIKDNKRDMLDPAVKGTNNILTAAKKEKQIKRVVITSSFAAILDLNKGDRPGYTYTEKDWNPVTWDEACTSDNPAAVYCASKKFAEQAAYKFVEEEKPSFDIATMCMPMVYGPIVHRIKKMDDLNTSVATVWSIVNGSSKEVPPTEFPVWVDVRDTAEAHVAALTSDKASNQRFLLGAGNYINEQIAAIAKKQYPDRNIAGDVSKINAESKGFKIDGSKAEKYLLGKPYITLQKCITDTISQLFELEKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q7R0</accession>
    <name>A0A8H7Q7R0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translational machinery component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_002739</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q7R0"/>
    <dbReference type="OrthoDB" id="1654884at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2186301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="23179" checksum="4B60E963E5F94726" modified="2022-01-19" version="1">MSLLTRAARSCNSISKAKYSLFSLKQVRLVSNDGSNSNNTTQSPFMSVLGDNNTQTDSTGLGAYKDLLSPLSSGQSFETGKDGISFDLQELLNSKSFAAQEGPHHLHINASYNNTILTLTSPNGQVLAATSGGTAGFKKAARSGYEAAHQATLQLLTKIQEKNLRINNLHIIFKGFGPGRDAAFKAFTSSFSGNCKTLTDATPVPFGGCRPKKARRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U6R4</accession>
    <name>A0A8H7U6R4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Maintenance of ploidy protein mob2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U6R4"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24375" checksum="627F61563860320D" modified="2022-01-19" version="1" fragment="single">GKKKTPKSKLSASSGPNNKPLFLCNPYVNNMLVKGSFKTIVELPKYVDANEWLAFNTFEFFNYINLFYGSIADFCTIQSCPTMSGGSGVEYTWTDAQSKKMKLPASQYVDFMATSIQNTLNDETLFPTKAGRDFPRELPGVVRKIFSQLFRVFAHIYYQHYEKVLSLHEEGHFNSLFAHFISFAKEFDLLDKKEMQPLQELIDVMERNGVITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U999</accession>
    <name>A0A8H7U999_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b-c1 complex subunit 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_007722</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U999"/>
    <dbReference type="OrthoDB" id="6369905at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000039">
        <property type="entry name" value="Ubiquinol-cytochrome c reductase core subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF209">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="11">
        <location>
            <begin position="44"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="12">
        <location>
            <begin position="185"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2177066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="440" mass="49679" checksum="4AB39E2BCAE2A4FD" modified="2022-01-19" version="1">MLYALRSFSRCRPFLHHHQLLSVRSITISQTAAGVTVATFPEPGLTAGLSVIVGGGSRYETDKTAGAAHYLKNYTFMNNKKRRALRIAREAELESAVLSRTLGYEYMSIQAQFLKGDEDYFTEILSDVVCRQKYDPFEFAHVQKLVGLESNYARASPRITGLEKAHMLAFRNGLGNPLFSGPLKINQSMVEAFSKEVYRPSNIVLIGRGVDHKKLLGYVHLNFDLEDTRKNEVMSVYYGGDERLLRDSDLGHCTIAFQGFPIGTHDYCAASVLREYLDSNSNIKWSLGGSLLQAIQQKLSLESQITCFNLGYSDNGLFGVQIDALNSEMSRTLNLYKESILSLNCDISDHDLYRAKNLAKMKCTNAIHNRLDFMDYMGYRILNGHNEDVQDILRDIDTIDQKDIQRVVSKIFSSKPSMVTIGKLQALPYIDQYVANIRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9I2</accession>
    <name>A0A8H7U9I2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_008138</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9I2"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="76"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2171758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="583" mass="63731" checksum="A8C21D2E2EF79491" modified="2022-01-19" version="1">MPRQSVSSSSKRENNNSVPLEVLRPRRSVGGSYALNKDSSMTLETDDLTIQSVASSGVGETTHNTSELKRGLKARHLTMISLGGTIGTGLFLTSGASVAQAGPGGALVAYAATGIMVFFMMESLGEMATYLPISGSFNNYAGRFIDPALGFALGWNYWYNWAVTLAVELSAGSIIMAYWLPNVPGWIWSLIFLVIMLALNLFSVKGYGEIEYWLALLKVLTVIIFIIVGILVATGAVGGHVYGFENYTLGGFQGMGVFSTFLLAAFSFQGSELIGVIAGETENPRRMVPRAIKQVFWRILLFYICALFIIGLIIPYNDPSLLSADVSNIATSPFTLVFQKAGLKGADDFMNAVILTTVLSAGNSGLYASSRTLYDLANEGRAPKIFRKVTKYGVPIYCVLLTTLIGGLAFLSSLFGNGVVYQWLISISGVAGLIAWLNIAVCHFQFRRAYVLQGFLVEDLPFKARWYPFGPIFAFLVCSFVLVGQGYSTWTATPIDPIALVACYIGVPIVVILYVVYKIVKKTKFIPLAEVDLVSGRQEILMHNLEFEGRKRDDPLEGVSILKPSTWKRIPSNLKSWRDAIHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAI2</accession>
    <name>A0A8H7UAI2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAI2"/>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034231431" evidence="2">
        <location>
            <begin position="23"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2175730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="208" mass="21968" checksum="954FC6DA33DB6ED6" modified="2022-01-19" version="1">MLTHMFTFLAVVAFAIMTMVSANGTKHQVTVTNSGFSPSSICIFPGDSITWYFQDAGHNVEETTDIGSCTSKHTFKSTTMQGGWRWSRQFKTLGLTTYMSSNNNDCANGFKGDIHVQDRCDPTSSSGNSSSESSSDSGSSSASPAPSSSPSPWMRDENTSTSSTPSSQTSPSSSSANVTPSATSSSSTRTQASWIGSVVVVTCIFLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UB90</accession>
    <name>A0A8H7UB90_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_002046</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UB90"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000702">
        <property type="entry name" value="ABC transporter (Adp1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF2">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034840832" description="ABC transporter" evidence="15">
        <location>
            <begin position="23"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="841"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="873"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="914"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="951"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="982"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1013"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1067"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="100"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="392"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="653"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="653"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2179196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1093" mass="121834" checksum="99AA2FAC2D9A4DF4" modified="2022-01-19" version="1">MRLWSSQLGLAVFAAAVMVVSGQENSLEDLDFSIYQNDLLPHPFHSSAKQSPAPWYLENIGGGDKDCPPCFNCMLPAFECKHFANCSEYDGKCKCPPGFGGDECKQPLCGALSDGRERDPRQGDHCECPEGWEGINCNAIMIQYVQWIKFVIPWSQLVVMALVIEVALRYSKTTKCAMLQVCNVIELHRKILETLKDQIPQVTFSCNKNKEDCDFQFWVDEIESFYCHLDECTFDQEYGYDSNKTNYACQTIDCRCMPGEMLCGKDGSIDLTDLLKDEIKGPATFKCTDGDCAFSEPAMDDLISAVFGDDSIFLSCSSGECLHYTFVPGFERPERPTNWTAFVAGLAGVTGFLILTGLGVWYFAKGNESSGYFKLDDDEAGKLMHEHIPATLIFNNISYEVNKLRILNGVTGIVHPGQVMAIMGASGAGKTSLLDILAKRTKSGTVGGEIYVNGHAIPNSQYKKVIGYVDQEDTMIPTLTVYETVLYSALLRLPRTMSTAAKRFRVMETLQELGIDSIKDSKIGSSGSRSISGGERRRVAIACELVTSPSILFLDEPTSGLDAYNAYNVVESLVTLARDYNRTVIFTIHQPRSNIVALFDHLLLLAKGHTIFSGQQMRVQSYFKSIGYDCPPGFNIADYLVDLTMHVSMPDQNEAQQDVGSSSSVEHSNRPIARRRGSLREEQEAALYTPHAPAGQTSGAVDTMENPNAEWASELGSRQTRLRNERLLKNFQASNVEAIAETGETRSNVSINSGTDKDTISPHLAQLIDGYKKSVVAVAVQDDIERALSHASVDDEDPAVPMAPNNIKVVSSHERPRWFTQFRILADRTFKNLYRNPMLMFAHYTIAVVLALLCGGLFYKVENTIAGFQNRMGLFFFFEALLGFMCLTSLQVFSNERILFVRERANGYYSPITYFLSKVLFDIIPLRVVPPLMIGLISYHMIGLVDGTTELLKFLLVLILFNLTAAALCLAIGVVFKDLSMANLLSSMVMLFSMLFAGLLLNKDSMSPYFAWLKYLSFFQYALEALLVNELIYLQLVEERFGLSIDVPGATILSTFGFNAKNYWPDVIKLSIMFASFIAFAFAWLQLFVKERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBV1</accession>
    <name>A0A8H7UBV1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBV1"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="92" mass="9945" checksum="DCF2C79EB1D06E8A" modified="2022-01-19" version="1">MTLVNDTKNPQMFNASEQPPVSEQSATGPSVREVPPPPYSPSSEQKKQQSPSHTVPLDRLGEDPESILCPECGYMLNIAARDAVANSQPIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UC19</accession>
    <name>A0A8H7UC19_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_003853</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIGH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UC19"/>
    <dbReference type="OrthoDB" id="6256716at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044215">
        <property type="entry name" value="PIG-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019328">
        <property type="entry name" value="PIGH-H_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10181">
        <property type="entry name" value="PIG-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved" evidence="4">
        <location>
            <begin position="83"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2180066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="175" mass="20108" checksum="166AA8B3AC133B9C" modified="2022-01-19" version="1">MKQSQNTLTPLTEELSYRSLPGVREYVVHSNERIWTVTTIAIVSALGILSYTTKSIPWAKWVIGSIFVLLTWIKLNTVKEERILAIRNVGVQVKTIYLSGRSISHFVERSRICDIIIHEAITIWQVKFYMAIIVVKQDRMKVVFEHLLPPLNPTLITAYRGVRSMMFSDSDPESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UC47</accession>
    <name>A0A8H7UC47_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UC47"/>
    <dbReference type="OrthoDB" id="2405016at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034947203" evidence="1">
        <location>
            <begin position="18"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="106" mass="10354" checksum="7195A34DEE1AB707" modified="2022-01-19" version="1">MKFSIALTTALIATAMAAPVTDSNSTTGPTPTATGNTVIVNGFAMPSASATNFAPAPDVSATGSISILGSATPKSAGDRSSIPAAGRYLTAAAIGLLVPASTSFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UD04</accession>
    <name>A0A8H7UD04_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UD04"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="96"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2174999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="323" mass="35657" checksum="102DB12996828F06" modified="2022-01-19" version="1">MGAQLSRRRKISQSKKAAAKMLDQTQSNSSFSSKSKGTELFGRLYHDVESSAYLYPMDETEQDRLHGQHFALKALFGGDILEPVRRAIDLDDNCHVLDVGCGPGSWLLDLATSYPNSKFVGIDVVDMFPSTIRPPNTEFHVRNILDGLNMFSDNSFDFVQMRLFASVLKTDQWATTLAELKRVCRPGGIIQLLEVDYKVRGNSTVNQFTTKLVEVMAKRDLDGEMAKKLAPALTQAGFINVQTDHRSVAGASVTSAGKGKFVVATQPYDSPNAMDDAVTGEFWAGEPGVKQKREEAPYQNIDGRSTLDVMARAHRVNATQDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDB3</accession>
    <name>A0A8H7UDB3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDB3"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="105" mass="11575" checksum="AEFE2765AE92ADFC" modified="2022-01-19" version="1">MFDSKKSTKSNSLFGKSKSDNKVHILPTKSSKSTTSKNPFKSNKKERTLSNPFNKSSSKKSSNPFSSSSKKSNNPLSSSSKKSNSFKDMFNNNGKSKRRSGILSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDQ1</accession>
    <name>A0A8H7UDQ1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_005371</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDQ1"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="179"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2176138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="515" mass="56560" checksum="55996275F2827C8C" modified="2022-01-19" version="1">MDELISRDLSSANHVKERNSDEFLDRRAVSPLTELTTDNASVHRSSSLKANRSGDRARSHMKSHSRTHSLTIQSMKPTSAGHNIPVHNNNGSSPVPAHFQGRRGSLPLLTVATKLPIKNKEFSSPVRSPYFANRLAASSSVLNSPIPEKGGVSINIAHPNSDLTNFHITSRQETIAKNLSYILCWYIFSTCLSLYNKNLMGKDRFNFNFPLLVSAIHTGLHSIITAMMMAFGGGRWNPQKGAKSVSMHDYLFKVVSIANKRSEVPCGLAAALEICCANASLVFISLSFYTMVKSSTPIWVLAFALLFGLEKPRILVISIILVMVIGVILTVEGETKFDMLGFTLVLTASVMSGLRWSLTQLLLQHDRLGMDNPVATLYHLSPVMFVTMAILSMIFEDPIGQFKNSEHFDSIAHVMESFGLMSIGGLLAFAMTLAEFHLIKSTNTITLSVAGISKEVVIITLSVLIYGDVLTPVNLLGLAVSIIGIIAYNYYKLSKSGKEQGYEHLPMHSSNKLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UE72</accession>
    <name>A0A8H7UE72_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_005418</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENND6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UE72"/>
    <dbReference type="OrthoDB" id="10265409at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024224">
        <property type="entry name" value="DENND6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677:SF0">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="187"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2176184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="739" mass="82722" checksum="FA3B8E7C805C7E28" modified="2022-01-19" version="1">MDIASTTPKYSSPLRANHSAADLLAKSPSPTLRPQLTRSQSTHSRNSSASSTHSPLNPHATNPSSLRHSVQVPISIFDSQEADIGETSGGYSTSYTQAHYKHSPASLTHSEPYLSHNHILDSQQSPSGSYTTGDFSDEEEVSSRTSSSDVFGVGTMLEDDKDITELHNSRATCLSPDVLSKFRQWMVGFCVVNFDLEIGQALDFVYPPVELAEYEEKNMLVLFCFSAFPDSNVFEVGDQVYNVRVRASGSGLAASGPTAEAGFLYGYVFFRQKKDEKIRRGYFQKSLVLLSQHPFVGLFSKVVSMLGPAYFELGQPMLEAACASIASWNAPRAGLSFSLPLLGTVLQVEIPYPHQPQLLETSGFNLNTFKPETQILASIPTGTLYKHFSNMLDDLWLLWELVLLGEPLVVMAPEPGICSESVIALVDLINPVIIDHARRYHTVEIIVPTLPFKIPTFGLSSPRIWQPPSNLILGVTNPFFSKAIGHWPHIVRVGQHQHRKPDGTIISAHGPRHNKPHAKPNGALDFVQGVTSKRKATFAKDKALLKMLVESRVRGHSSAYVLNNILRRHFADMTERFLAPLDRYFDQLLPSHAVISKKKGQGQLKPFQADQFLRFLKENGPQLQFRSTFKTRGDPVREFYTQFLKCGNFATWLRLRTNEAQKEIRERYIRMLCDTNVMNMVSSSREVETVDLLVRFQEALVLAQNDEEMHNSINVEKLQLQIDTIIQTLPADLRTSLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UE77</accession>
    <name>A0A8H7UE77_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Gluconokinase</fullName>
            <ecNumber evidence="3 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_007351</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="3 9"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UE77"/>
    <dbReference type="OrthoDB" id="275177at2759"/>
    <dbReference type="UniPathway" id="UPA00792"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442:SF3">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2182421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="204" mass="22751" checksum="9DFAA18A5EF4EB63" modified="2022-01-19" version="1">MAQEQVRSPVPVFIFMGTCGCGKTTIAAACKKIVNCELIEGDELHPQANVDKMSKDIGRSFAGIPLQDEDRWSWLASIRDTFVQKASHLYEDPKVDENSPHRAVFVTCSALRKAYRDILSAVNSAKVTVTFVYLKGSPELLQSRMAGRSNHFMHENMLKSQLATLEEPDESTENVIVARIDPPTDVIAKNIVNAAKERKLIYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEC9</accession>
    <name>A0A8H7UEC9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_003641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEC9"/>
    <dbReference type="OrthoDB" id="3512845at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2179855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="20980" checksum="6ABCFB74824A1D18" modified="2022-01-19" version="1">MLVLVGLPGSGKSTFAMKLAATKPEWKRVNQDDLGSRRACEHATKGHIAKGFNVVIDRSNFDPKQRKTWIDIAYQNNMAVDCIIFDVTVDECAERINVRQNHPTQVEGHFGIQVLHRFVSNYTPPLLENPEGFSRIVHLPPRPSPECTAQDIEDAFNILNIATEIPDAAKYRIMDHPRQNHQTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UG90</accession>
    <name>A0A8H7UG90_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_000554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UG90"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01135">
        <property type="entry name" value="C1.5.6:_HAD__Beta-PGM__Phospha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2184641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="225" mass="24431" checksum="5BCF011BACDFE3DC" modified="2022-01-19" version="1">MSENHKSFVAKCVLFDMDGTLIDTTPLVEKHWRSFADEHGLDAEKILAMSHGLRTIDTLKHWTPDLATPEIADQYERKLTHVSEGVSILPGVTSLLASIPHEKYGICTSAKSYMAEARLKQCDMDIPKALITADKVAHGKPDPEGYIKTGEILGYSGADCVVVEDAPAGVKAAKKAGMHAIACLTTHSLEQMREAGSDYIVNDLGDLQVQVLGDGQLEFTITNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGM4</accession>
    <name>A0A8H7UGM4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">V-type proton ATPase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_002018</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGM4"/>
    <dbReference type="OrthoDB" id="10261947at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10580:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005772">
        <property type="entry name" value="ATPase_V1-cplx_fsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01101">
        <property type="entry name" value="V_ATP_synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015945">
        <property type="entry name" value="ATPase_V1_F_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR015945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2179168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="121" mass="13576" checksum="B835969C1A9819D0" modified="2022-01-19" version="1">MSGGTSLQKDRNLIAVIGDEDSVTGLLLAGVGHTNQQQKKNFLVVDAKTPLVTIEETFEEFTKRKDIAIILINQHIAEDIRELIDGHNQAFPTVLEIPSKDHPYDPEKDSVLKRVRRLFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHA8</accession>
    <name>A0A8H7UHA8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MAGE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHA8"/>
    <dbReference type="OrthoDB" id="205198at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50838">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="2">
        <location>
            <begin position="60"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2179843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="270" mass="30947" checksum="81348A4650616EEF" modified="2022-01-19" version="1">MSTRTRRRQIQASERELDEEDYAESSTSTSQREAKRSRLPESTYDEIDSQMTLEQSSQDLERKVNDTVRYALACEHRKQIIRRDDIAKKVLGSSSRAFPVIFEKTQKKLRHLFGMELTELASKEKPTAAGAKKTQKAEHKAATSKAYILRNILPEEQNDPDIIHHTDEEHESTGLLYIILALLFVNEQTMDDETLTAHLDRLRVPNESESFGDRPKVLDGYVRQGYLARQKLALESNQSDRAVFQYSWGPRSKAEIPEQNMVGFISSVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHF2</accession>
    <name>A0A8H7UHF2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit OST5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003765</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OST5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHF2"/>
    <dbReference type="OrthoDB" id="18408at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007915">
        <property type="entry name" value="TMEM258/Ost5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05251">
        <property type="entry name" value="Ost5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2179978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="83" mass="8648" checksum="EF46500B382E75E0" modified="2022-01-19" version="1">MSAMVNTNQDLWNEGIPVSAPIPPSLFPLVAYVTVSVGLVAAGLFAVQKRGTPLTEQLTLALPASIMLGVGSVFTFLSVGIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHI8</accession>
    <name>A0A8H7UHI8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHI8"/>
    <dbReference type="OrthoDB" id="10323113at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="142" mass="16113" checksum="8FD1FC3CCF281DAC" modified="2022-01-19" version="1">MVPPAELHIKRDITMLIASNPTLCLEEPRSKKPKIFEKSCLKNTAEQLPKCNKRVCFAEDPQTVYFRKMDSSRSLLNDGHDPEIEEYNPNNLDSGSDLTDIPPPLPEKRILKRSVSHCDLDAYWGDELDSKLTKMDLGKVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHJ0</accession>
    <name>A0A8H7UHJ0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="252265at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39211:SF1">
        <property type="entry name" value="ABNORMAL SPINDLE-LIKE MICROCEPHALY-ASSOCIATED PROTEIN ASH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39211">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="902"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1351"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2502"/>
            <end position="2525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="480"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="838"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="917"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1362"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1377"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1389"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2503"/>
            <end position="2513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2181957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="3101" mass="350098" checksum="57C6D3E163193BE3" modified="2022-01-19" version="1">MTTQESEPAIFELVGIHNRITLENVYFNGMHALRHIRLRNLCDKYVTVKMRSNLRHQIVFQLFNENFPSDEKDSAEDDDYVTNTVAAAIASRLNKSTDEPSNTHFNQLFNYVNHVDQVELEPFQTRHIVLGLLPNPTANRAATGHMEESDSENANDEKDKVEDESKSKGENRFQPRYDPGKEEDTYNTFDVNGMLFFFGYMHDGPTPTTDAQVTTTGAEPNYQLSIKFRSTVCQSMLWTDISEVGLNFDDCVVGGTYFKDFTISNKSEIDLFWLLNTVDLNNTGKDDCLRFTDYDTGEVLDNKPIPIYSYRRVRVTFKPKEVGEFNYDLQVENINDSRNLEQTRIHASVRSVLKDETLMISSGSVIDFEDCCAGAWTTQQLVLKNVSELPIEVHLVSEGAEMYFDIKTGLDGSKELANADRKKLLPPRLLRDPYSGASTTNPTTTPVASISELSAPNSEVSSRASSPTLAHPRGKDGDMSSVSFSAEPSVSSSLRPTRPSNRRAMSGASMSFNDDSDTDAEGVRIMRPSESTDDSSVTSGNNAAQENYTRIEDIVIRAGTERRIQVSYRPEKDGSPTDFNAGQLIRRNFRIILEYGLYRSGAPKERKVVQCKARSCTSFVEAIPREINFGDTDVGTLKSLPVNIFNRSDIPARVELQFRSKVLNCQRGEITIPPRSLYELKLDMYPRKVNAEYRKQLTLVNYLNRDNDQIIEVRSTNIDKNRVTFHSLFYRILTATGANFIDFGPIALNSPALRTYTIDNISNHVLKLEITTSLPDDFVIYTRKKTKKLDNEQKRLEHVEDTSADNTPTQVSSSQSLAVDATEQALSDDASEPRKASPVNQAGKMSSVPSGVAKSLSSNQAAVSAVRQIRNHIASRKDSLHSDTAYLDLAIPNVANSTRRKLPNLKTITQKSSSSSIHEKFKEKDRESTRKPVNGVLKGSTSPLLGGNDRDSSSSQVPRRPVGFARDDSQNASTRSLGITAARYKSRINLDWSDITGMSRVPFDDLIAVLEHCSKALPPLFPKQSVEEKFVRHQMAWRHELDRLIEKEIIVPTKQVEIEAGGEEEVIIVFTPNGATKSHIQNTPRKQDARIFLRLIEFDRSIEQTQFESLKDLDHSQIPLRELIVRSHLCRSVMDLGQKNINFGLLERNERRTKSIILHNRSETPLLYTIRKSGSIASGDITLGSGRHGVVRAFGKREIDFVFEPTLPGQFLERLVVENIRDRENDQVVLVKANVRKPSTFFIKSLHMDFGVCVMGQTASRVETIVITNTNKQSRTFEIRTDPKDMQFDFGSIEFDYVIEDDNEGTLTKEQEEEIETLEQKLKIARRKGHDDKVKKYLKKLAKLKKTTFEIESNVHGEPENESTPSGDKSTSQPEARPVKELATKTRSDTLSTMSSQTSSKYKQTANSVIFPLDAHATKTISVYFKFVRNSAATTPLLGLQQVSGRIFVHEHKNTDICKKIVFTAQICRDQKSYMSIMTTDTDINVPQSVGMVNGNGQYINGAQDLVESQSPTSTHDPAESQLPEVEGLSLERAFLDCGRLELGQSSSFYVNISNKSQKILVFEVDVDPQDKGFIDGYENLKQMLQPEEQRKVVFPLVPQTIGWQQHHIHFRNVVTGTVFPFTVQCLVHRNQYLQFPSLGVGGELDLGYSYVDPGCKYSQVTPLLVENITDDDLYISCQSNLSQQVLIFQDEKSERGQVEKMVFKRKSMTTVWVAVQPNLLSGYLNTSGDECRELVGGLKFSIFIKQDSLEPINDEGSGDEEFCLALQQTVKFTSLIGQSNLEVSDKILNMGYTDVLGGEFYGYFTIKNMSGRLPLDYEVECSSSNIVVDRPGGTLDGWRMSELKAKAFTDANARKPSYDASWSISSAQITFKLFSTMYGLLKEKITVTNKFNSMEVFDIEVRLFVDCGTLKIPSIDAGVNWPSDISELSETSDRNNHKDTHQLPVIKWDEIYVQPVKTIADENDDKKQQRLMFKNLQDYSGDDLPQLPSFEVENSSGALMHLVPLSDLQLEAQWSLENTCAAQPDPSLPFRACGPAVVLSPHQVSSITVHQPSPDTLSDNDMEQLSLGERGSAQGLLLLYDRVTQTVVKTFDLEAKFCASLAELSVKSINIGKIGHTASWKPTPFYFSLRNLSDIMLRYSIDAPPCVTLEPTIVSREQTATEYELAPMGQCRIEGILDAKACEDQTPGMRQFPIRLINKYNPDNVMEVTLRAQMTIFELSFERLTDNELVLPVLMHPLASQNVPCDNWFTICNTTDDDTRFEIGAEIVPDLKPLIKLDVLSRYSNTPLKGGFTLNPQGKIEIRVRAHPIEDTRLPIDRPNLLDPEGIQFANVWVSTRLLDSKDNDTRQFSELIVVRGILSEASMLSLSERRVDFKVITSYPEGEDSDEEEQSATIQRLSPPSVVPDIAHFAVNNLSQKQSLRFKVTLEGPVEFSAHKVIRIGQLDPSGIGILDPGATFPLTVEIIDPKGSLSGQFRVHVDDLDSINGCRQTTSINVIEDRRKIRKSSSKKKKDAANETKGDIATMTKPSLQRAETSTMMPYINLRGCKRVDEGSLGGRFELDLGQQDMGSSAITKKITMENTTDVSISYRIRCIPEPDREWLKISRTEGTLESMYESVSHSEPHVVTLSFSTAIRNIYSTYLIIENIDNPVDTKTIRVTMEVVARQNVRRGQLGESENNSVFDVFVNGVDLSQTIDMLNIFYGSEYTARSMLIYNRESVPLEFSIMSNLLHDDPTEILFSTSQSATRLFKSLTVEPKNHIRIYIRFRPLPSKAIKDEIEDTEHNNDVVEQKSVEIYINCRLVKDYQQTVLLQAECRMPAFRVEYDSTQALMGTLQKCKLDNSEESPTWNLHFNPPDHYMVIWNLQKTPLSYQIVNDTSYFLLEYIDGENIDIQPGQCQKVLIKPNTKILLDNAEAIHREKYLQEYVTVYNKDRPQENYWIPLRMSFGHVSNFQLASGYRSSHAYSMLESHIVSFLSDFNGSMRYLSTFDEDGDRRGDLAFKYYYIVDQLVYYSTVKTGGNFFQLASLLFCSLLNHDIFKPFMPSQLFDSKEHPGQRIWPDSLRIWVFSLHYYLSFFPHRPALLSALRKLYSSLVTGQDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHT6</accession>
    <name>A0A8H7UHT6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_007169</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHT6"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="519"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="57"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2182242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="555" mass="60280" checksum="931BCB144E5975DB" modified="2022-01-19" version="1">MASRENDNEALIGSHQQSYGATATRSDSQDTIDTTSITTTPNKVSEDYLNGANVFFILTGLWMGVFLSSLDSSIVSTILTRIGSDFNRYNDAVWVATAYLISYTALQPLYGRISDAIGRKNTLVFASGTFFLGSLLCGAAPNFWSLVAARVVAGIGGGGLNTMSSIVTSDLVSLRDRGKYQGYGNISFALGSVIGAPLGGFITDYYSWRWTFYINLPLLFLTFYVTGVYIQNYNIQRHSDGSYHILKKLRQVDWLGAITLVIAVSLFMLATSLGGNSMPWSHPLVIGSLVGSAVMLIVFVAIEAKHAKNPIMPWHIISQRTPLASSFTNFWALMSSMSLIFLVPLYFQSVLGFTASRAGIYMLPKIISSSIGSLVAGYYMAHTGRYKSYSICSGICLVLGTIVISSWHPDISVFWLILGNALDGYALGSLLTTTLTTLLAAVQVKDSATIISISYLFRTTGGVLGVSTCQGVFQAILKSQLFQNITGPGSAEIIDSVRKSVSVIKDLPPDVRELVIESYLYAIKCAFSLTIVFASMALISVLFIERLELTTNVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIV5</accession>
    <name>A0A8H7UIV5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_006373</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIV5"/>
    <dbReference type="OrthoDB" id="2382073at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="29"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2183367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="415" mass="46377" checksum="BEAA32797D195CC0" modified="2022-01-19" version="1">MALTKQLQAVLDKRQEILKLRRLVVNPPDAIDFSSNDFLGLARSKVFRDRFLDELQTFNHPPLGSTGSRCLDGNSQYALDLEARIAKFHHAEAALLFNSGFDANSGLFSTIPQPGDIIFYDELIHASVHEGMKLSRAGMKIPFKHNCVTDLESKIIKIWQEDKTAKKTRNVFVAVETVYSMDGDIPPLQELVTMLRRYWTKDENGYIIVDEAHATGVFGKHGRGIVCREKLEDEIFARVHTFGKALASNGAVVLGTETLKNYLINYARSFIYTTFMGFSSLASIRCAYQMLEEGDSLQAQQHVLALVDHFRATIHLPHGQLLPSNSPIQGIVLDGNDKVRALAEYLKARKFNVKPILSPTVPTGSERVRICLHGDNTFEEVDALVEATHQYFQSPARALPITTAFSSSQLVISKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UN96</accession>
    <name>A0A8H7UN96_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CwfJ C-terminus 1-domain-containing protein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002446</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UN96"/>
    <dbReference type="OrthoDB" id="444325at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061632">
        <property type="term" value="F:RNA lariat debranching enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07380">
        <property type="entry name" value="MPP_CWF19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF4">
        <property type="entry name" value="CWF19-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="359"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="422"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="HIT" evidence="7">
        <location>
            <begin position="502"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2186008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="680" mass="75399" checksum="7926882E983850F1" modified="2022-01-19" version="1">MVVGSVNGKFTELFTKAKAINSKHGPFEVLLCTGNFFGPEETTEDLSKLLNNEIDGNCFGKNLDILWPSLINVTSCSVPIHTYFIHGNIPIPAIAQSRIDQNDGELCDSVYFMGKRGLLKTTQALRIAFLSGSMDPEVYAGNELAKMEAEAEAEAEDGTAKTEVGIRYTIEDIKALKSTPVAQNMTAGVDILLTHEWPQDVHNMSSQSSDPTIESMSRPVAEIAATLAPRYHFAAAANSFYEREPYRNIPGFEPAGARSAQHVTRFIGLADVGNPQKARWFYAFNIAPMTEAPMSVLLAEPPNTTDFPLVSVLDPHMIGQKRQMEDGNGAFFWGEDGRDAKRRGKQAATGDEPPPGYVCKRCNVPGHFVRDCPQAKNASGSLPEGYVCRICNEPGHHIKQCPQAGQNKEPTKRGGPPEGYVCRICSEPGHWIQDCPVKEQQDKERDSNRQEIANRGTDACWFCLSNPKVTKHLITSIGNEVYATLAKGPLVSSAENNMPGGGHILLIPITHYETIQSIPMEAQVDVITELERFKSSLRRMFEKFGQDMVVTEISRHSGRNSLSHAHIQIMPIPKGKVDDLREILHKEGAKLGMKFQPQLPNDPSAHFFKMDLPDGESMIHHIQRGERFNLQFGRQALAKLMDIPERADWKACAQSEEEEKTEAQDFKAAFAEYDFNITGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UP90</accession>
    <name>A0A8H7UP90_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Magnesium-dependent phosphatase-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_002477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UP90"/>
    <dbReference type="OrthoDB" id="2865258at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010033">
        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010036">
        <property type="entry name" value="MDP_1_eu_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01685">
        <property type="entry name" value="MDP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901:SF14">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1 MDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12689">
        <property type="entry name" value="Acid_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01131">
        <property type="entry name" value="C1.5.2:_MDP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2186039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="20289" checksum="86A3E9C0000B82E7" modified="2022-01-19" version="1">MTKNNIPSKLPRLIVFDLDDTLWKYEVDCTYGPPFKFDRKNKVVVDCKGNPVELFKDVLEIFALIQTFPGTQIAIASRTTTPDWAAQVLKLYTVNELGSLHSMCSAFEMYDQSKTKHFRRIHQKTHIDYKDMLFFDDNPMNLCVEPLGVSVVMLDYDGMTMEVFLKSLQLYAENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UPA7</accession>
    <name>A0A8H7UPA7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UPA7"/>
    <dbReference type="OrthoDB" id="2534759at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702:SF1">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2186084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="398" mass="44858" checksum="F54E9B9AB5FE55ED" modified="2022-01-19" version="1">MTHPLDSTDSGVELPEELPPKSVRSARKTEVTFLDTEAANKSPAEPPKPYVRPVKSNPNKHFAQSAQRRSSLQTLGSIGRLQDFYGKKSLKHNKAGMLGFSLANLSEEPEDLDRLPTPIAPPPSWHNLDVETDLDILLQQAFDDIESMLETWSMIAGPPEDQQRVEVLPLLQSVTEMLNSVKNYILHRHDLSDLAVSKLRTAALKLLESMTHLENKYRSLEDNGDSTSGYVYNNMDYGNLNIERNAILEYLNTIEQYGFNPPHHVGAPYAGYSAIIKNLMIKTSSRDSDTSKSSINHLKFSDWLKDNGQWDNELDDRQAFLETLAACKLRFDLTFPNYKPAEIARKTSAGLDMLTQPWLKLEAALVIFTRTVAKEFRANVLETRRKSRFIDVASLAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCN3</accession>
    <name>A0A8H7PCN3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YncI copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_009124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCN3"/>
    <dbReference type="OrthoDB" id="4234at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08545">
        <property type="entry name" value="YcnI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2230">
        <property type="entry name" value="Uncharacterised protein YcnI-like PF07987, DUF1775"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012533">
        <property type="entry name" value="YcnI-copper_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038507">
        <property type="entry name" value="YcnI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07987">
        <property type="entry name" value="DUF1775"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034061778" description="YncI copper-binding domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="YncI copper-binding" evidence="2">
        <location>
            <begin position="19"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="210" mass="22399" checksum="5E61A26F69EC5A9B" modified="2022-01-19" version="1">MKSFIAICLFSLAALSSAHVTFTVYSGQPGSYLSTALRVPHGCNGSATNAISLSIPDNVYSIKPQVVANWNLTIQYRDLTTPVTIEGQQINQTVSNITWDNGLLPNDEFQEFGLQIALPDSGYNGTDKLWFPVLQTCVNGSTFWGGIANTSSWDQYTGHPAPTIELTNASASTSSGQATASGVQSSATSVSTSMVWTMLFLVISSFVLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCW4</accession>
    <name>A0A8H7PCW4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCW4"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022111">
        <property type="entry name" value="Rhodanese_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040503">
        <property type="entry name" value="TRHO_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43846:SF1">
        <property type="entry name" value="TRNA URIDINE(34) HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43846">
        <property type="entry name" value="UPF0176 PROTEIN YCEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12368">
        <property type="entry name" value="Rhodanese_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17773">
        <property type="entry name" value="UPF0176_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="178"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="390" mass="44820" checksum="D4192B51A865A5B9" modified="2022-01-19" version="1">MQRVCRAWVAPYLSHSPKLAWKRPHSNSINSIVGFRYWSTRAAEPYRPVAFYSLRPWPQSTVSRLQSRIKDQLQRFNVVGRIYLASDRGIGGINAQLCVPVCHIEAVQTFFDTLPEFKGATLEYNHGMEDTDQPIFQRLKIMQKPNLVAVPDTLKADILSKAPKHLTPEQWHRDLSTCSNDTLLIDMRNHYEYDVGRFNNATRMNVDTFRESLEVLDELVKGKDRNEAIYMYCTGGIRCSVAGAYISDKGYSNVNMVSIVNIPTPSRRDRLILLFFQLKGGITNYGHFVRNNKVKDSLFRGSNFTFDGRRGERITDDVLAHCHQCGAPCDVLSNCANNFCHLLFIQCPACQKKHEKLCSSECRDVVNGHKEWNHPYDYRSQIRPPLRQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD66</accession>
    <name>A0A8H7PD66_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_008246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD66"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF50">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YOR292C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2171520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="249" mass="28670" checksum="ED231BC2E24FF7AC" modified="2022-01-19" version="1">MLALKRLNKFYTKSYEKAPFKTLCVTNGCLAVISDVTAQTITYYNWQASTKNEAVNLDEKLPEKLQEHEELKPRPPPRFDPYRTLRFALYNVAVAPLVGKWFMFLEKRFPMSTVQQAAGGWLKHNDKTTLKRMITDQTLFAPMSLSLFFTVMGLVETGSIEGVQAKFKDAYLPAIKANYQLWPAVQLINFKFVPLPYRLPVVSTVGIAWNSYLSWLNNAAKEEEIATHKFEEEERQYDGTRGEQIKLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD70</accession>
    <name>A0A8H7PD70_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD70"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="84" mass="9796" checksum="09ADE72826D742F2" modified="2022-01-19" version="1">MDSRYRRSPAHTPRHKDAGAAFRQEETSHKEDALLHKETIDIMSEDSEDDEPIATLMGRWWQWRPCPNSWLRSVMADSSLLTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDN3</accession>
    <name>A0A8H7PDN3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDN3"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034503990" evidence="1">
        <location>
            <begin position="22"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="183" mass="20815" checksum="064816D5AB0FF4D5" modified="2022-01-19" version="1">MKGLVLPWVLATLLLAQGALARLFSTGTYAISPNINEPNYLAATFNNANGTKQGIGKVTNSKQLYRWKVETSDGKWTIKAEEAEAYLGFNHLHGHQYSADITSTPQEWKIEQHERREGTWRIVKPQSRDHPDYGDISVLTYHGYHSPYDGNSGKTNAPKVVVQHLEYISKPSIIQFWRFTRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PE17</accession>
    <name>A0A8H7PE17_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc ribbon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PE17"/>
    <dbReference type="OrthoDB" id="10356510at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034152980" description="Zinc ribbon domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13151" checksum="7244CC56B3DEE02F" modified="2022-01-19" version="1">MYGRRRRPVLGTALLVGATASAARSSAERQQLAMEQARLAETTRRLEYDRQMQIQAMQTEEAVRRGIASAEIQRRQSEQSGVPVTQNSQPLLQCNQCKQLNQVNNKFCSNCGNNLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PE20</accession>
    <name>A0A8H7PE20_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial dicarboxylate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_001425</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PE20"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00784">
        <property type="entry name" value="MTUNCOUPLING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="107"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="207"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2171949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="32614" checksum="D275B2FFA886785D" modified="2022-01-19" version="1">MSSSTPFYFGGVASCAAAMVSHPFDLAKVRLQTTTGAARSGMLKTMFTIVTKEGPIALYSGLSASLLRQATYSTVRFGVYDKLKSAITTGNQTGRLNNFPSFLHIEPGFVQMLVCSSIAGAMGGVCGNPGDVVNVRMQNDGQLAAAERRNYRNALDGVLRMSREEGLSSLMRGVGPNVNRAILMTGSQLVSYDMFKDLLLNTAGLKDGAGVHFGSSLLAGLVATTVCSPVDVIKTRIMSASTASGTGALGAMTSMMRNEGVMSLFKGWTPAFIRLGPHTIVTFMVLEQLKHWHQAFNAPKAVVRAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PE71</accession>
    <name>A0A8H7PE71_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PE71"/>
    <dbReference type="OrthoDB" id="10418582at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="361" mass="39894" checksum="D7BA1EA09A97B49A" modified="2022-01-19" version="1">MATAHSTVAPMNIKTSVKASRPLRTSHSSKRTEEDDSLNKFLADWDDSLPSFSKDNSSNKEWKSVVAAWNSNAFEFDPFIAGKALKPSNDISNDTALETSNDISLDTVRAILLSDELSIASTALGEIFALASVHRSCVRPAVADLCGICTSLATEHAIESVTTSVIASMICTLNAKITSIAAHVEAAESEKLLDLVTRWNTELEKFQWDGDTEQFRAPLDVNKFRMWICENFPAVDERGFDVDLLMLIRPGNKNYKVERHATVQDRGPDDSSSSPSTTANEDICIDKNMEQTMMREDVELAVTHVTEADTLDFLWDDPEEEDSIYDDESDDSDTERGIGIFDSATEISGADVTESDWSEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEY2</accession>
    <name>A0A8H7PEY2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-rRNA processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10039566at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022185">
        <property type="entry name" value="DUF3712"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF1">
        <property type="entry name" value="LIPID-BINDING SERUM GLYCOPROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12505">
        <property type="entry name" value="DUF3712"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1567"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1567"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1610"/>
            <end position="1619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2172665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1627" mass="169290" checksum="94C81168DE2804C7" modified="2022-01-19" version="1">MSDAASITPARNHAAEPEFDQHDNGSINSNDADEYYEKPPQKKRFYKNKKYWIICSIISVIMIVVVVLLIIFVAFPKIAQLIINNSSITVNKASITFAPPANDGSSSVSKRQDAPFVADGNNTFYMAMEAGLGNTGPFGADIAFTSPITVSYNNVELGVVNVPGTHVSGGHGTLTSNSPFNITNMDAFNQFAIDMLAQETFVWNMAATAKITALSRTADVTLNKNVELKGMQGFPEVKITSFALPGDDPAGGIQVSLGTALTNPSSIGVYLGTINLDIGYQGVYLGPVSASNVNLAPGVNNITLNGRLIPQTSSQNLDVISDMFTRYVAGESSNTTAKGVSAAPDGVHPVSWLSAGFKTVQLNVALASATKLQLIHAVNLGNLDLDFTNQTAYSPISSAPEVTANFSIPFGFSLNITEVTQAITLGTNSTGPIALLSSGYVNSTSDQKAGVMKFALQNAPLNVYPDKHEAFNLFNYNLTGATVYDFNVQGNATVIAATPIGIVKMSNIPLNTTTSLNGLQHLNSTATTINSIDVTGGTAENLIMAINCTMVNPSNVQIAAGDVQLLMTSEGVELGTVTLPNLTLLRGANTVTAQALFNPKGTTQGQNLLTTFVAGKDNNVGIAGYSNSTAIQSLAYAFGNVSLASVLPGLKSQLIQSASLVVLPNTVQTTVAGTSVTIANPFSAGLTITQVKAAVTYAGMPVGNIDADISSNPIVVGGKATTPSPSIPIKMNLAPASVALLLRENAASAGLDLNPIDALLTMGGFDIQGQQHIDATPALFQSFNISDFVIKALANLHVDLQLESLLNIGQYSDTLQIVQTNVPTKTDSSITYLIPVVGQPLVQSIINGAKMTFSSTILSQATDTGFTVQLNGQLTGTGPFDATIGFPAPLTVAWQGRNIGAVTMPSIQTVADKGATFSISAHFAILDQDAMADFSAYMLLQKDFVWDISGTDVSVTAMDYTFTNLSMTKSVTLTGMAGLVNDVKINSFNLPSNDPAGGISLVLETTLTNPSQVGVDLQGLGFESYFGSVDIGPVAGTNVNLPPQGTATVQMKGRLIPQSGSDGLNALQTLFDNYLSSKETALSVKGSSASGPSGQISWLSKAFQQLTIQNVMLPGGPNNLTLIPAVTIKQFTFDFTKGAYSPDSSSNDIEAQFKNPFGFPLSITGLQETIVAAVGGHDMASLAPPFSPATTDTSTGIIKTGFEHVPFKVYEPVEEVFNQFVKGLTLTAGGALELKGNISKSAVSTAAGDFYLSGITYDVQSQLSGFNNFGGQFTINSVDITGATPQYVILKLTITMTNPSFITITVGDISFDTLVMGINIGPTILNNLTIAPGAHQYAAEFHLTPNGANAPVVSAALSGYLQQQTMALNVKGSTNSTPIASLKEGLSGVSLTGSLTGIDAHLITGGVVKNLNLLAFSADTYITIQNPLDVQFSITGIKASIMYQGIASYFQLASIDATLSSPFTVPAKGTATSGAIPLVFTDPIAHLLDLLAILGKSSIVVDISQNATIVVGDGFNNVLTYAQKGVTIQVEILPGTAEALTAKMNGTSSALSSPIISATSGSSSAAASAAASSTTTTSESSETPSSSSSSSDQTTATPEPTPSKSDDSSHAAATTTSSKPWPLNLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEY3</accession>
    <name>A0A8H7PEY3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEY3"/>
    <dbReference type="OrthoDB" id="2373574at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2172435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="294" mass="34272" checksum="10A7363484DA1E4F" modified="2022-01-19" version="1">MQWYKTKAEALMPGYLHVARDLNNRGAKSYARVKTYKEISDIIDNYDCVYEVVTSEWKEMYDFDGEGISETPEEIIDNFVTCHSQISPEKVHVKKCITKNKISLHFVIPNTVLPNYKAMKNRFKLMMSVKGLLHRDLYDSGIYNKDRLIRTVRSDKCFQNRPFISDSEDMHLFVSLPMKILNELEVPPKHKLNSIIEKYKLDAFKPHSEIHPGVFRIMRIRPSLCIICNRMHESDHAYININEMTYGCFRAEGTVIKLDSDILSISVSRLKAQLKEFDINQSDIDLIISRSKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PG19</accession>
    <name>A0A8H7PG19_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_004668</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PG19"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21386">
        <property type="entry name" value="GAT_Hse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11805">
        <property type="entry name" value="SH3_GRB2_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16978">
        <property type="entry name" value="VHS_HSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="14">
        <location>
            <begin position="15"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="237"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="205"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="393"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="438"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="393"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="472"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2173294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="518" mass="58718" checksum="998D21A81F0C99DC" modified="2022-01-19" version="1">MFSRTNPFDEVVTSATSENLTSENWELLLNVCDRVSRSSPDARLPEPLRLVSWHINDDADLQLSFSVPSARDCIAAVQKRLQSKNANVQLYSLSLAQALVKNCDLTVHREISSRTFTSTLVKIVNDKTTHEAVRKRALELIQTCAFDFRSDPSLGLMNETYLSLRSQGVQFPSPQKPKKETQTELDKQKEEEEFQLALALSLSESENKSQYKAPASKSTTANSQKATDAPAQASEPAKPSRVRALYDFQPTEQGELGFQKGDIIRVLESVYRDWWKGELRGKTGIFPVNYVEKIVDPSPADLMKEAEMEDQVMEMAPKVEQLISMLSNIDPRRDSFAENEQLQSLYNQTLAVRPKLVKLIEKYSLKKDELVALNEKFMKARTSYDKMLENSIARYSSPPTDPYSQQSSHYAGYPPAGQAAEPYPAYPQQQRQDYYANSVPQQQPSHQPVPTATPDVYGGYQQPQHSGGYYAPQQQPQQQQQQQQQQQQPPQQPHQQPQQPNAYQGYNTPQGHEPVRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PG99</accession>
    <name>A0A8H7PG99_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PG99"/>
    <dbReference type="OrthoDB" id="2399195at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="351" mass="40519" checksum="4A98F4724E7006A8" modified="2022-01-19" version="1">MSSINSLPHKILRNIFEFCSTEDLFNIMPVSTLWKATASQVVAHSFITKDLVMWVDQEGRIWPIVINMLLQYSLLTWYVSYVLRPPFKLREQKSDTLDIYNLMFGLKRPCLRLITVGDDNQWDYLEKAGPISLKHTGKKTMLASDHSSADKTFHQWRFTYNIEYLYRKNRKIDGERVFVPEIFECSLSFLNPRRAHRTKLTWYVKKHIKNIDPTASKTARRTKIHGEVSPAEWHNFFEQHSNEVGPQILTKFNIVQTGFCGLSQKQFVLHPSSNAWLPLCKLRRALIRALNLICNKAYPTDLQHAGYSTNAKKKNEIDSNAPTAGSSHIFTAASTCADNHTELLVKERTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGC5</accession>
    <name>A0A8H7PGC5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Succinate-CoA ligase subunit beta</fullName>
            <ecNumber evidence="13">6.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_004559</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGC5"/>
    <dbReference type="OrthoDB" id="1552at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000004">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03220">
        <property type="entry name" value="Succ_CoA_betaA_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034723">
        <property type="entry name" value="Succ_CoA_betaA_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="14">
        <location>
            <begin position="38"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2173185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="439" mass="47029" checksum="FF6A62729007F6A1" modified="2022-01-19" version="1">MFKSLRSTTAIASKVASASRTANHQQKRFLAIHEYLSVDMLRSYGINTPKGAVAKTPQEAYDIAKKLGTDDMVIKAQVLAGGRGKGTFDNGFKGGVKTIFSPEEAKQMAEKMIGSKLITKQTGAAGKPCNSVFVVERKYARREYYFAILMDRKSAGPVLVASSQGGVDIEAVAAENPDAIITMPIDIHKGLKREQAIDLATRVGFSPAGIEQAADTFEKLYKLFIEKDATQVEINPMAESSDHQVLCMDAKLNFDDNAEFRQKDAFALRDTTQEDSREIAAAKHNLNYIGLDGTIGCLVNGAGLAMATMDIIQLNGGSPANFLDVGGGATPEAVKAAFEIITSDPHVSSAFVNIFGGIMRCDVIAQGIIAAAQDLDLNIPVVVRLQGTKVNEAKALIAESGLRIFAVDELDQAASKAVQLSNIVKLAREANVSVKIEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIE5</accession>
    <name>A0A8H7PIE5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_004441</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIE5"/>
    <dbReference type="OrthoDB" id="2276320at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2174418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="140" mass="15489" checksum="A1D834F73B78B682" modified="2022-01-19" version="1" fragment="single">MHPYQGHNRPPVDILPAPTGPAANTVPVGETPRRKRTRAKRSCDMCRKKKSKCDAEVNHPCTNCKNWKTECVFLVEQKKRGPSTGYVELLESRLKRMEALIDNLARSNGKSEDSSSPEDNITPPPSVEDSSNTSQASIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIH2</accession>
    <name>A0A8H7PIH2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIH2"/>
    <dbReference type="OrthoDB" id="2427532at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="324" mass="36225" checksum="DB523A663D8C38C1" modified="2022-01-19" version="1">MKRSSPSSGTSSSTRPESSWNDCPAPAITYHFNPTEKHSLVKRHVSHCIQTAKRQSRESSSHRTLSLTPINTSVNSGGLPSPPVEADHEASQDFSGNKYAHIVSPSATPTEEQQRDARFNDNVVACVVQKLKDERPCSPDEESSHGPTVQNTDHADNLPDEEDIRQKIADLTAEKHRLFQLMKSKMQGTSETSTSDTSEEDHCSIQNQQLPKSSATLSDNEKENSSIERAEEAMSNTLSTKPTSPSSSSPRPQTYRSRPLSDRGYHHPYRPSPSSRSTYNGAYRCHRIDYSPRFAPPMRQNPYGAPPPLAYRRRPALDRRPPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIW0</accession>
    <name>A0A8H7PIW0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycosyltransferase family 49 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_005845</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIW0"/>
    <dbReference type="OrthoDB" id="411524at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042285">
        <property type="term" value="F:xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051292">
        <property type="entry name" value="Xyl/GlcA_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270:SF52">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-LIKE PROTEIN GNT13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2174783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="53666" checksum="D247FD272D964456" modified="2022-01-19" version="1">MLHGNASKRMHEPRTIHLKNQPNYAPPTSRSCQVEICNPSGKCSIWSPGSYQWKDLADQSLYRDVASVNVGFGCQATLKVDQGVDQTELITVSNEKVVCNNDLAGLDTLCWNAIELTVEANLYTAGIQIRDAMNRPDTGSQELVLVWESQTPTHSDIEDITLVSQFSVNRLEIFERVLDAWNGPVSIAIYLTHREDIETFINYFKDNRKRELYAGCTITIVKPDYTSNLHLRYPINHLRNLAITASTTEYIYVIDADFVPSRKLYHHSRSKLLPHLRKSRFLAMIVPCLAVTESNLDNIAIETTSDIRSLFRSNKAYITDPRAGHGPTFTRQMALAHNLKLGDYYEVCYESQWEPYYIVHKSAPLYDARFRNQGGDKQSHALMLNALGYRYVVARGIFMVHTDHSAMVWPGGGLEKAQKQEREWTYFDGFMREMEQLFGKNVRWPRGCSAKTIGWQEQRRDILGLAAGSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKZ3</accession>
    <name>A0A8H7PKZ3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_001267</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKZ3"/>
    <dbReference type="OrthoDB" id="2396066at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF5">
        <property type="entry name" value="ANCHORED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034047794" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="25"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2175620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="115" mass="13049" checksum="697888FFF36E288F" modified="2022-01-19" version="1">MKFSVIAAVLAIASTVSAAEFGFTSPKENAVYHTGDTVKFAWHDYTSKNESITLVLANQGKAHHWHPYKDIVQLHKPFPTSYDWHIPKGIAKQRYFLVITDDTGSQPFSPYFYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PL37</accession>
    <name>A0A8H7PL37_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_005377</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PL37"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2190:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000011">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="9">
        <location>
            <begin position="714"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="204"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2176144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1149" mass="127445" checksum="39777564948153AF" modified="2022-01-19" version="1">MTVDSNSAKGSDPNPLASEDTPLLPASPTTQVSEYEESLVFSLIFVLPSAILFVISFIACVIPSTWSAYSFITNYWHYPGSLPLTCWLLLYPIVWSIPPTINVLAWHGIFRNPLTLPEAQPKIPSTRVGRQLLAWSIPRALLYYNIIFLVSIALTILFTSELRRFDWLAALAAVWGAFVLTWVSSQINFYARRRVKRLIEISEMSDDEDENEEEQEADDDVQAEAAGSTAQKRSRTNSTASSGKSVALSAASQPAPKPKMIARIPSNHSRLLPARFPLYRLTTESTLYLASFIGTLLLLNIILRARESILYPPPGERFTTKDGTVLHVDCQGSTSFGEKNVTVPTILFEPGASVLASHHVAFLTELEQAGQIGRYCWYDRAGYGWSSSGVLPATAETEADQAYEVIVQEMNEESLIIVGHSFGGMIARMFAAKYPQHVVGLVLLDASHEDELYWTEVHGKPSSTLAWAIRKWQWSCVLYDFVWLILEPIGVDRWIPIWSIGDEGWISYGEKTRAGLLNGRALQASNLNASVPPGAPIFPPDLPVSVVTSGELGCQFKECQGDEEDSKKAWTELQRDLAYNLSLVHDWTIAPSSAHILWRDEAGASVVKEAVVKMFRSKFGHTPASQSMLSHINRISRATYRTSAVARAAGAVHGRTPLTVTKHPKFQRDARFQALNDTHLKYFQTVLEDNAIKYDKDSESEELAPYNTDWFNLYRGSSSLVLFPKETSQVSSILKYCNDNHLAVVPQGGNTGVSGGATPVFDEVIINMSRMNRIRKIDTVSGIAVADAGVILESLDSAVSKNGYMVPLDLGAKGSCHIGGNVSTNAGGLRYLRYGSLHGSVLGLEVVLPDGTILENLSTLRKDNTGYDLKQLFIGAEGTLGIVTGVSILTPQRAKSTNIALIGLNSFEDIQKAFIQAKIDLSDILSAFEFWDKDCIEVVSEKMMPGVQFPIASEKPYEFYALLETQGSRREHDEAKLETYLTKLLESNVAQDGVVSQDIKQTKQLWAWREMIPEGITKYGPAITYDVSMDIPLLYKLVRDARAHFSEKNMLGADKDYVKLIGFGHVGDGNLHIMAATNRNDYKLQKELDEYVYSWASKNRGSISAEHGIGISKIQYLNYSKKQPVIDLMQRLKKQIDPNGIMNPYKIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLK9</accession>
    <name>A0A8H7PLK9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_005501</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLK9"/>
    <dbReference type="OrthoDB" id="27975at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16650">
        <property type="entry name" value="SP-RING_PIAS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="6">
        <location>
            <begin position="28"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2176267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="215" mass="23261" checksum="259D9B70DA91BC52" modified="2022-01-19" version="1" fragment="single">EENETSTTSTTAPLSATASGSESTGVDDDIECMQESIKVSLRCPISLLRIKEPVKGVKCVHVEASNIACFDLNSYLCVNRGLAKWKCPICSKVSISSDLLYDEYFESLLTSMGDDVTHIEYTSDSRNWMAVEFEAADDDDDGSDGEGLSSSPVTKSEPVAVAQAKRKLDVDLVNLVSDDEDEAQKMDNANKRSKSDTVVEQSSNAVDRSIGNAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PM33</accession>
    <name>A0A8H7PM33_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_005747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PM33"/>
    <dbReference type="OrthoDB" id="10288920at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2176507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="140" mass="16213" checksum="9B731100B4FE3496" modified="2022-01-19" version="1">MSYLNHVLPAADAPDYSMFTCCDPFNDSELCMELPDLELPIDMLPDFSEDEDDEDDENYQYFAFDYTMDKHICLLCEFSDCGFHCLAHNPPTDFQLDVVPIDCDLMLRESIIYEEPLLSEFAPDEDVDLSFLSNFEFAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PM38</accession>
    <name>A0A8H7PM38_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PM38"/>
    <dbReference type="OrthoDB" id="5569779at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="277" mass="31206" checksum="F33E53422F15CDCC" modified="2022-01-19" version="1">MPPDNINPVIPDVPKVPAPAQPSPLPPEPVSEPNVQPSPPEGSNHPPPDHLPQPPPQSVPPPYKGIRATLREIFEGRNISGAPENNKSNDKWDETCIQWCKQQKDARKEGKEPSCKMVCFRRKVDEITSQDTRDSKDTKDQENDPPTRWNPLRGYSIVVVDGKASCEDHVDDMNKHSMQNPKNIEGPAKYEVDLGEQVEKGEAEAKRLVAKTFTPMYVMTQRYINSWTDGTQAAFFERFAESVKRADAYHIVCDSAKKVYDNTFRNSKGNDDDGKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PM64</accession>
    <name>A0A8H7PM64_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PM64"/>
    <dbReference type="OrthoDB" id="2220023at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="246" mass="27170" checksum="43E37685CAB00185" modified="2022-01-19" version="1">MYFNLPTQQEQQQQQQNQKQQEQHRQYIPADDQCSSKLQDYHPTVPTPNMSNIHDESWAAIVANLNDHKSSPPLVTPNTLSRLLNMRLDGQHSSSHPSQSASTQTQESSSQLKYAELIQNVKQLGATLSDCGMGDELQKAIDADEGIKQYLASPNNLDQSEDATLERLSAIIADFTNILSKRPAPKVKSNSDSRVLTTNITAVITTPPVNKMSDSPDNRLVGIQQEQVLSPSAESVNISTSNQPIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMQ5</accession>
    <name>A0A8H7PMQ5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">tRNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_005503</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMQ5"/>
    <dbReference type="OrthoDB" id="19141at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10289">
        <property type="entry name" value="GST_C_AaRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000047">
        <property type="entry name" value="tyrosine--tRNA ligase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053836">
        <property type="entry name" value="Arc1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21972">
        <property type="entry name" value="Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="TRNA-binding" evidence="9">
        <location>
            <begin position="221"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2176269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="42461" checksum="D5B6C6E8DC9F53C0" modified="2022-01-19" version="1">MPASQKATLLVQAYTGNTESSQDVKTLVAKKPELLGTTPAEKSEVDSWIAWTEKVFDAAGCNIEEALETLDKHLKHNTYIAGNNFTVADIASFADVHTRAEKIAVTTYPNVLRWIDLIQNIVVKGNATAEKEFPLIALDLENVPEPVITVALTIIVLQKKDKKSEVKAEAAAAGAAAAATATAAAAAVTDAVVPDKKKEKKAKKEKKEKAPPAPAAPEQPVVSRLDIRVGHIVSCKKHEDADALYVEQIDVGDPEGVPRTIVSGLVKWYPVEEMQNRIVLVLCNLKPANMRGVKSQGMVLCASPADGTKVELLAPVDLTKVKPGDRVYFEGMEGTPENVLNPKKKYWETVQPDFKTNGETVAYFQDKPFLIKSSSGEDIKVKAATVTEGLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMT9</accession>
    <name>A0A8H7PMT9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMT9"/>
    <dbReference type="OrthoDB" id="2120024at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="112" mass="13002" checksum="DBB734780059778B" modified="2022-01-19" version="1">MASQIADTPLLALPRTNMLVTFRPFRIAQRLSGARPYTTKPEKQLPFIYQYGTPLVKCVLIATVTNLALQQWWTSLEYVEYRKDMDAEINQLNDKIKDLEARIEKSSVEIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PN56</accession>
    <name>A0A8H7PN56_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PN56"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="34481" checksum="0489393706A2C0DF" modified="2022-01-19" version="1">MTNNLGSDTTADEAASFYANEIKGKIVLITGCTWGGLGAEAARAIAKHDPKLLILAGRKQEALDDTIQKIKEESPEANLRTLIIDLASLESVKKAAAEVNQYSEPIDVLINNAAIMASPYHTTKDGFEGQIGTNHLGPFVFTNSILSRVLASSSPRIVNVSSEGHGLTPIRFDDLQFKKGETYAKWIAYGQSKTANIMFARELAKRYGNKGLVAFSLHPGVIQTNLARDVQISEFQEPIYDAFGNTLDFSTVKWKTLPQGAATHIVAAFDLSIKDKSGAYLDDCQVANDHLRPHAKNNGDDEKLWALSEELVGQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PN97</accession>
    <name>A0A8H7PN97_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_007779</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PN97"/>
    <dbReference type="OrthoDB" id="2281547at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051999">
        <property type="entry name" value="Mediator_complex_subunit_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019680">
        <property type="entry name" value="Mediator_Med1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12881">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12881:SF10">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10744">
        <property type="entry name" value="Med1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med1" evidence="9">
        <location>
            <begin position="155"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="684"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="712"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2177123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="729" mass="81033" checksum="E590F97005209952" modified="2022-01-19" version="1">MSNPTERKPNSNLASIAGLKSLLDDISAQWYLNTDADQRAGSASNVVGSTNLHPFGTVNIDKARQDFLKLTTAVRANCSQFESEVIGDVTKIGTGAEPAFRKHLMHLKVRYIQSREQANFESTVVRVKSNLQGTVRKLSSALSGSEANTFASIRTKSLQEIAEDLDLACYLDTSEKPGFDSPVTTITTAGNIIVIDVDIDDKGTVVKAKLTYATEMHQDDKVDRILLDNLKSDDLEGFQTNLKALSFVDKMNTKYSPIDFFNISKNLMEDFKTIYNQELLMASNNPGQVMNNGHGIPQMHVDHPGLSIFFWAGPVEMLETEWGQLEASIENAEIPATLKTATKMWISYEDSNTMTTYPPEAKSHFLLSFDETLESILAEENGEHFMIIDEPQQQDTGINIRYLKTSPNHPNASTVPVSFVANFDHPIPVSAYTCSQLANILGLPGINGLSGERDHSVDQQDDVGLEVLLVNECMHGTDNSKQSAVIQDLLTDNVRWRVEAENTIQNYVYMNSTAKRGKLLHRIPFGHPAQLYGIMQILRKQLVFNHIFHSVFNAKSMPKDGSDVVMNSEITLDDLLQDKEEGTIELELSIFEAPTSVQVTFMAPKTETNTFALVSFTITVPDSIPTAPVVTLQNPTSEDDQQLSWNSDIFDQQKLNTIIQSSYSIPLLVRWLWLKMKDAQEPLTVSSPKKKVAARSNSYFGTPEKTTKRSRTSLFPNSSPAPSKSMDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNB2</accession>
    <name>A0A8H7PNB2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDB1- and CUL4-associated factor 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">WD repeat and SOF domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_007559</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNB2"/>
    <dbReference type="OrthoDB" id="10249065at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000132">
        <property type="entry name" value="DDB1- and CUL4-associated factor 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056948">
        <property type="entry name" value="PNGaseA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12222">
        <property type="entry name" value="PNGaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034169427" description="DDB1- and CUL4-associated factor 13" evidence="11">
        <location>
            <begin position="20"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="domain" description="Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A N-terminal" evidence="13">
        <location>
            <begin position="49"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="654"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="697"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="865"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="908"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="12">
        <location>
            <begin position="941"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="993"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2176905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1032" mass="115897" checksum="C67E267382761B8F" modified="2022-01-19" version="1">MKYSSYLLLVAGLACTTIAKPVPNNAQANVTAPILKIDQVDIVPIVKTNAHACTVNIVDHVVGTGASQTYNATYHPPKNCPGPWNKVVLTYTGASKGRQFDRLSAIWMGGVEVLRTSTAEPTKNGIHWEFETDVTKYSSVFKSEQPLIMELGNVLNDIYNGSYHITTDLTFYDASKEYPDPQAADVVVPISTGTDDQAWYHLDSDSDFGSVNVTLPTNIRSAYLEVYASGQSNDEFWYSNAPTDYANQINYTGIGNGPFREALVYFDGHLIGSTVPHPVVFTGGIVPSLWRPTVSIGGAFAIPSTWIDVSPFVAWMVDGKSHEFKLQVSYEIRIRVWVSTTYKHMVQVINAESFWLIDANLHLWLDNGTERTSGKVLINSIQRNATVQTKSSIGKNLDAVFKVSARRSTHVMGYIDTSKGRIFNEYKYNLNYRNTLNFDNDGNNSSWVPTIHQISDSEQKPQHTSQGGFLAHTISTDYSWTIGGGNNQTIFPDQSIRIDGWTNGDDQEKFTEKLGHMSTSTQFHAKQKGSAYYGANAISNANQTTGMGQTKTSVNFRDNHRCYSRSVSAFNSTITSDKTTLKQFTDNYLTRQMKVKALSRSSTDYVRERAQDIHKVQKNLDPNIHPFEKGREYVRALNAVKTERLFAKPFLGALSGHVDGVYSMCKHPYRLNAMISGSGDGEIRIWDISERESSWVVKGHKGTVHGICATPNASTFLSCSTDKTVKIWDTDEGIEPIHTYVGKYAFTGLSHHYTEPLFATSGNAVEIWDQNRSEPVQEFNWGVDTTHTVKFNYTETNIFASCGTDRTIALYDLRTNQPISKVVMAMRTNAIAWNPMEAFIFTAANEDHNCYTFDMRKMESAINVLKDHVSAVLDVDYSPTGEEIVTGSYDRTLRLYDARKGHSKDVYHTKRMQRIFAVQFSMDSKYVLSGSDDGNIRLWRAHAAERMGVKSVRERAHLEYSAKLKDRYGHMPEIRRIDKHRNLPTAIKKADKLKKQMLGNRRKKEDNRIKHSAPGSVERQPERKKAIVGVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNH3</accession>
    <name>A0A8H7PNH3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="9">3.2.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_007714</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="9"/>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNH3"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF1">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE I_II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034440219" description="glucan 1,3-beta-glucosidase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2177058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="377" mass="41818" checksum="1A592A28F7D8FD05" modified="2022-01-19" version="1">MVSFSLDSALVACLCFLTIVQGSPLQKRAGTAWNYWTMKAWGANLGNWLILERWMDSTIFDQNAPNAQDEWTFCQQASNPAQALTNHWNSWITESDFQKLASVGANHVRIPVGYWAFITPDSGEPYVSTGQKAQIQRILGYCATYHINAIIDLHGLPGSQNGEAHSGHIGSIDFYTSYNQQRALKTVQAVVDWMNSLPTNQKNQISSIEVANEPRTSSDAQLTTLKNYYTSAYAKVHASAYQVPMMFHDAFKGLNYWSDFLPAPANAVIDLHPYWAFPPATSQSSIISDVCSKASPNAGFHIPVLTGEWSLASGVSSTTTWLRQFMDTQVSVYQKGAGAVMWALKNNINSNVWSFEQLMSEGIINNGTFSRHTNSQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPD8</accession>
    <name>A0A8H7PPD8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPD8"/>
    <dbReference type="OrthoDB" id="10346415at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="307" mass="34169" checksum="AE1995FC7B89FD01" modified="2022-01-19" version="1">MLSCEADCRRVSQQSIPSLSSVSTDSSTSLDTQRRVNRRPKPPKGLASPTGYQSHSKRHVALNMETYQPMLPFASSPFPSNPYATLPLGYYNDPSAYPIAYPTAAYEETWNKSRHYYGNQGIKVYEPIMPVPLAVTMEATMYDCVANEFDYDDNIPLAYFQSIGQASNTKQNIKGKTPAHKSAMNKARIDRVPTPTTVTKVKSPSSSSNSNTKTLGLRKNHKSATNISHATSPGHKRNSEPPSKRKDNVVESRRAANTALHHKWNLTPKETSPKVHEVVPCEPYPNTIKRFLAGINRFNTKSVKSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQ49</accession>
    <name>A0A8H7PQ49_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_003480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQ49"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="7">
        <location>
            <begin position="67"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2178227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="489" mass="55247" checksum="4F6CC41DCF829E7F" modified="2022-01-19" version="1">MNQSPSSSYWQACSPHQPDKNDKQEQKDANAVGQQYDPQELQVGIRHRTISPVFEQESDELDPAYGGIAGFISKLYQALQAPDNGNKHARWTKANGKDMFVIDCIPKFTETVLPKLFKHCKFASFVRQLNIYGFQRDTDARKYKELKDRESCRWYHIYFRPNRKDLIHLIRRKTSVCKRRRRTAHLIKAEDLDTETIIPVGSDSEHEEYYENMRSLPLVKSGKRKSQPGASQPVALYNSNRTGTANEYSTTHLNQQILELKQTCENMQKSFFQEISQAYEQIQAQKQQMDMLQSVVEAMRHNSGTSSSRGNNNEVATANTALQPYLGDLNVNDSPKIVDGGGRMDSSMYTTNQANQVEQRNNLPPSAMVQFQKYNHATHEPTTTPSSSTAQQVSGMVVPQAPQPDAGNIGIELSSQRSGQTHHPFGYNNFAQVPQTSHDWSVFPGHGNDPSMAKFTALHYQQQAGPAQPGFTSERRGFAPDYGLMPQHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQA7</accession>
    <name>A0A8H7PQA7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_003087</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQA7"/>
    <dbReference type="OrthoDB" id="10069349at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23804">
        <property type="entry name" value="UBCc_UBE2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000031">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="9"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="163"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2177840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="259" mass="28389" checksum="EC21BC80C1AA1AB8" modified="2022-01-19" version="1" fragment="single">SFVVDLSPSAIKSVSRELYALQRTPPDDIQIIINETNLADVQAWIRGPDGTPYENGFFKVKLLLTKEFPNVAPKGVFVTKIFHPNVADNGEICVNTLKKDWKSDLGIGHILLTIKCLLIAPNPDSALNEEAGKMLLEAYEDYAKRARLHTSIHAQGGKVEYSRLDSCRKSDAQDSPKSDKNPLSSDKTSTRSISTTSATDVTSKPQSSPKAGSNVLTASTINNITQKRSAAEADLEVKPVVKSQKTAPMDKKKRNLKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PR89</accession>
    <name>A0A8H7PR89_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PR89"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="113"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2178994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="242" mass="26657" checksum="E4C2EB9547770125" modified="2022-01-19" version="1">MSELTSEQLDELFGSDVDSISEEEGTKSQLDLPTVNVISEKFTAIPGLRLVRQGLSHAVQSTLLEFIIAANYFQNETTNQAMHFGDLPDSFAKVGTWAKSCTDLLNDIDRHPLFNQAIINLYRSGEGIRSHVDLQKFDDGILIISLLSSCVMIMTPASEELKNASSYQNDEIADNVGISIHLRPGDVLALTGPARWDWAHGIPAREIDVIHGEQIQRGSRVSITLRKLKCSAVGAIELSQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRQ3</accession>
    <name>A0A8H7PRQ3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ty3 transposon capsid-like protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRQ3"/>
    <dbReference type="OrthoDB" id="10309667at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045358">
        <property type="entry name" value="Ty3_capsid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33223">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33223:SF6">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19259">
        <property type="entry name" value="Ty3_capsid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ty3 transposon capsid-like protein" evidence="2">
        <location>
            <begin position="50"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2179052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="332" mass="38896" checksum="5F3EE54FF80BFD48" modified="2022-01-19" version="1">MNSLNIPTYTASEDPEKWLEIYNDAAIRNKWRSGEKKMAEIPNNVDTDVQQWMTSQDFDEWDTLKKEFVAHYKKIYSAKQTVERLKYAYQRSTESLESYTETFERRRKRHVKETTRNLDCTKLTEKQLIKYYINGLKSQSQRHLIRKQNPKTVKDAQSLAEEYDEEQDSSTESSDSDTSSVEVHNPNEIRIRISNSKPKEFDRPQINGITRDRYHKHGTDARFDRYERVDVMLLQRPSQRGRSSSAPGTVPSTPDQPSEDKMEITPPMSPPDESVRNYSVGDDNEYMWLQRKQNGLRFNMTSKFLNVNANFRIDRYNLLPAARTSAPALTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRS7</accession>
    <name>A0A8H7PRS7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_003304</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="296793at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048685">
        <property type="entry name" value="COG3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048320">
        <property type="entry name" value="COG3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20671">
        <property type="entry name" value="COG3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04136">
        <property type="entry name" value="COG3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="833"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="864"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="948"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="979"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="12">
        <location>
            <begin position="862"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="516"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1174"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1248"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1361"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="530"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1200"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1362"/>
            <end position="1380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2178051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1433" mass="159934" checksum="04EC60D6A77630A5" modified="2022-01-19" version="1">MTARAQHGPSLEEWEEKTRLSGLEQKSVFEINDSCAELPLPPELLRAISNSPISQIHSPAIDFPEIQIQSPPRSPPATSPRFPALPSARLAVQSSSLQRSLSTTQLLAESTAADDTNAQKGAEAMGFDKPINNIQQFFDWFAKTELEMEQDQEDIYRQVAMNESNTSDRLSKLADQLAEGLAFFNHLEPISKKFNSANEDICTSPSFHAMLRQLDESIAYVEAHVQYRDSELYLMRFRQCMTRGMTYIKMYIIKTLREIGYEIYKSSPSKGQKMSAAAQTTMLYAKFRALGQKLRPLSFELEKRCEGHKEYFSLLTDAIGSYIQVRQQLLSPIITAKIQELGPYNENILEFARNGCGYILNICLEEFQLFYCFFDSGEEELYSYLEHLTSYLYDYLRPRIIHENRIEILSELCNIFQLHIIRDLEGADVNKGHTLAFSYLVRNILQDTQSRLVFRAESYIHNDIEKYNPTTADLDYPNVLQIERKSSIILSPPAADTKQAAAWHNDPATLDVAEDSDGSLHEATDDTVVSSSPPSALASPPSNFTDNNASWFPPLQRTLWILSKLYRCVRTSVFEDLAQEAVSICKGALISAGESISNNQSKMDGQLFLIKHLLILKEQLAPFEANLIHAGKELDFSHVNVALSAFTKGRTSIFNPNALFDFAQSGIPRVVEISIDSRREIDRELKRKCEDFILDSSQSATEPISNFITQVSAFQVANNMRTERLALSDQSFATPSSAYGAFEAFREAVNARLSFTMHRLGQYLDDAKMEAILLRPIQMNISSRYRQFYEIVSNQYDLETLPKQIPSTESMALWISQLVEQGKVLDDDLFKRLFMIYIKSLLLLLLPLLVHAQSEDTNINIHDPIFWVKIVVIIILVILSGIVAGLTLGLMSLDETNLSILSNSGTPTQKKQAARIAPIRKNGHLLLTTLLLTNTVINETLPVLFDGIFGGGIIAVVASTVLLVIFSEIIPQAVCSRHGLAIGAFFAWPVRILICILFVVAWPIAKILDKLLGSQHGVLYRSAELKELIAMHATTQEKGGDLQTDAVTILQGALDLQEKSVRHAMTPINHTFMLSINTILDRKTMSKILRSGHSRIPIFDGPDDQALSDRNISGVLLVKSLILLDPDDNTPLKDVKLGTMPQVDPKMSLFELLNVFQEGGSHMATVYGLDDDDESTISDDGTDSSIVPSSKKKGRFIRASGSSTSSSSSSESHNFFSRLRRGRKSDIEKGLDTDDQTNKGDHIIDVKAETAEQDEAGNANDIDGKTHSTAATPSVKVPAVNRVIGIITLEDVLEELIQEEIYDETDVRKLASLTAMRADTANGERVIVASHKIAPNVLAQLPAGGKRGVWKKRRRLSFESNRSLDDREQRREALRKQKEMEENEENADSVGDLPPNSPGGGSDTTGSRHRIVARSMTDPTGFEMLTNDSDKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRZ7</accession>
    <name>A0A8H7PRZ7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_002042</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRZ7"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19503">
        <property type="entry name" value="RecA-like_CDC48_NLV2_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19511">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000661">
        <property type="entry name" value="calmodulin-interacting protein 111 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001985">
        <property type="entry name" value="Chromosome 9, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="231"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="507"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2179192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="741" mass="81890" checksum="FDB9B6A8D4CD841A" modified="2022-01-19" version="1">MQFRVQAASPKHAPQRILFRLESLVELGIAVGDIVVVTLLENADHNQLAKKGTCVGEAWIDFSLTSDTIGIPAVLRKSARYRIGDSVVVRQIKEQPIEARTIQLLPCIEQSNAVNEELALYLKEYLVDLKYVIVGQEIEILFRGQPCRFQLMQAKDQSGTLYNNDSNTLITTVQPTKATIISAPIEKAEVQTQKMSYSNIGGLEEQIRIVREMVETPLQNPQIFQKYDVRPPRGVLLYGPPGTGKTLIARAVASETNAHVILINGAEVLSKFYGETEQKLRNIFEEAQERAPSIIFIDEIDALCPKRDEAPGEMEKRVVATLLTLMDGISTSPQAKRQAGIVVIGATNRPNALDEALRRPGRFDREVEIGIPNAIARYSILSTILRKIPNSLENEQVESLAATSHGYVGADLSAVCREAGLKCINRLCADPLWEQSRDMQAVVVTYEDMKAAMAEIRPSAMREIMLEVPKVYWNDIGGQADVKSKLKESVEWPLKHPDAFARMGIRPPKGVLLYGPPGCSKTLMAKALATEAGLNFIAVKGPELFSKWVGESERAVREVFRKARAASPSIIFFDEIDALTVKRGSDGDGGTSVADRVLSQLLNELDGIEPLVNVTVVAATNRPDIIDPALLRPGRIDRILYVNPPDLASRREIFRLQLAKIQCSPDISADELAEKTNGYSGAEIVAICQEAALQAMEADIHAQMIKAIHFSKAIISMKKRITPEMIQFYDDFRTKSGLKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSF1</accession>
    <name>A0A8H7PSF1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_001872</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSF1"/>
    <dbReference type="OrthoDB" id="204784at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000137">
        <property type="term" value="C:Golgi cis cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2179023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="104" mass="11883" checksum="80CBF656F005C023" modified="2022-01-19" version="1">MRREKIRGTICFLGGILLVFLRWPFVGFGVEIFGFLNLFGDFFPVIFGFLRRLPIIGTILSHPAISRVIIIEVLLPSFVFDTHHLTTLNLHSLHHAKVEHAFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PT08</accession>
    <name>A0A8H7PT08_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PT08"/>
    <dbReference type="OrthoDB" id="3364649at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013218">
        <property type="entry name" value="Dsn1/Mis13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778:SF2">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08202">
        <property type="entry name" value="MIS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="389" mass="44654" checksum="F09EC04D3616C4B9" modified="2022-01-19" version="1">MTALTMISHLNDVRLQRHYNELHEMIGLTISLARNSDIKRDSKNYVKQYIPSPQTMEQVTGFLQTVYSQNDKSLRKATQDTMDYRPTTHSPISKPSSKQIDRRLEAKDTKPLAIMFDDDDFNHRESLWNPGRRSSFMYRTKQQSSFTRTSVALPHPHLEPKNYYKHIPADMPDPMRMRQLLTWCGHKLITSRESTQIEGKSSMAESIAQPASNSTDSKRQPNSKNIRNVKLIEKMEKEDKAWRNVAMKLNNFHASILDSCPPLPKAGEDNGVGNALSTRFQQYYLEGISSEQQQFLNKYCTPSSIDDIDAQITRVVESLQTKVDVIQETLTTKLHDQRNAEQFGKRVLEKMVDVLNKREGIKADLSDPSCCLMPDTVELLRVLANDDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PT32</accession>
    <name>A0A8H7PT32_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SMG9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_001587</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMG9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PT32"/>
    <dbReference type="OrthoDB" id="79514at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039177">
        <property type="entry name" value="SMG9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14270">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14270:SF0">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2178741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="49335" checksum="AA5FD351165496E3" modified="2022-01-19" version="1">MMPSEERERHTLVGSHSQATGSEAQPKRQLFDFGAVNEKRTRDRRRKKDTGAKRDGGREVGRDLGPRAILQAPVILERRERPDGPKLPAQQDRGIARRLNTDAELSTQDDVKESTVVKMMNESEEFRTEATLRALADYPGHFVVGIIGKQGVGKSTILSSFAEQPDKTFNTQKPAKIFDHQTTGIDMYVTSERIILLDTQPVLSWSVIEQTLRHGSTDGLSSDIWRDLKTLHSIMFMLSVSDVVLVVSEGAEADLDTIRCLKRADMLKHGLPEFPLISPEKLGFSRPDIHLQPQVVFVNNKCQDLQFSQLTYDRNIQLLQSMLSDSRIEWQGLISFASALPRFKRSPNRPNLFLLPYTSNLTSKDEEDEDLESLDDLLRQFRNQVFAAPRKSGKRGQISERDWFRNAVKTYDLILRSDLISEYLRTLRRIKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTU1</accession>
    <name>A0A8H7PTU1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_004011</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTU1"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13994">
        <property type="entry name" value="STKc_HAL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF191">
        <property type="entry name" value="SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="193"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="156"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2180222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="565" mass="62909" checksum="42A6160BA9778093" modified="2022-01-19" version="1" fragment="single">RYSMGEENRSPKSSRWGLERKISTKEGGLLHSLFHPSRTQSTASSAIASVDEEAPQKPLQEQTELKLPVRPASPNQSATVSLQAPGSPGGASSRPNSPVSSASGNNIPSVNNPRFQVFEDGTHKHHLIMPSVSKLTSSLNGLTGLFHQGKGGHFKLPMWGDKKEHGADQLDQASDEEKKPNKNGDLSLTAKWGTCQEIIGKGAFGVVRIAHKVDPSVPGTGERLYAVKEFKKRNDETPKQYVKRLTSEFCISSTLHHNNIIQTLDLLPSSEASSTYCQVMDFCNGGDLFHLIFETNSGLEAAEANCFFKQLINGVEYLHRMGVSHRDLKPENLLLTSDGCLKISDFGSSECFRMAWEAAGSKKNGAIHGSTGICGSEPYIAPEQFGKGEFDPRLVDIWSCAVIYMAMRTGKHLWHVARPDDQHYERYLMFRSLVDEERDKARRMRSLHRTCTTDEERKAEAERTEKERNEGILKARETIRRKAKEGGYDVLEGLEFAAKKLIYRMLDPKPSKRLYAADILKNEWFESIWCCQSTDEQQTIKSLKPACAELPSMTSSPSLEQTSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTU3</accession>
    <name>A0A8H7PTU3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003881</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTU3"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2180093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="372" mass="42056" checksum="DF0665FD769629DF" modified="2022-01-19" version="1">MAATADTTLHSVLRSLGKDRNSNTDKGEVKLANSTIDTTKDAILKRGDANKGDIKKSKPVDYDQVWAAGTKLVTNNTLEKNHGNDPILLAPYNYLSGHPGKSIRSKMIQAFDHYLQVPPVSLAVITRVVEMLHNASLLIDDIEDDSTLRRGAPVAHHIYGTAQTINSANYAYFLAQSELRNITEPDLQSIFTEELLNLHRGQGIEIFWRDSITCPTEEEFIDMINNKTGGLLRLAVRLMMATAKTPNRDCTRLVNLIGIHFQIRDDYMNLQSKDYTDSKGFCEDLSEGKFSFPVIHSIRSDPKSRQLIDILKQKPQSIEIKKYALKLMEATDTFAYTRHFLRNLNDEIRQEIVLLGHNPHLEKILTILDIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUQ0</accession>
    <name>A0A8H7PUQ0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUQ0"/>
    <dbReference type="OrthoDB" id="2209940at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="entry name" value="Haem-degrading domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00761">
        <property type="entry name" value="UPF0303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010371">
        <property type="entry name" value="YBR137W-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002696">
        <property type="entry name" value="PRK02487.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255:SF1">
        <property type="entry name" value="UPF0303 PROTEIN YBR137W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="HbpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008757">
        <property type="entry name" value="UCP008757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="GlcG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2180250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="158" mass="17594" checksum="32670940B96C1BF0" modified="2022-01-19" version="1">MTDYSTLLPQLLDQEERLQFTKFNSDDALSLGLKLIENAKAYPKPVVVDITVAGHELFHFSMQGTGPDNNEWVRKKNNSVMRFRHSSFYLGQYIASQGKTLQEKYLVSEDDYVVHGGAFPLIIKGVGAIGTVTVSGLAQQDDHGVVVKTIEEYLASQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PV34</accession>
    <name>A0A8H7PV34_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PV34"/>
    <dbReference type="OrthoDB" id="406833at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2181109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="88" mass="10149" checksum="8ECB46D766CE7BF0" modified="2022-01-19" version="1">MRQLTKERCVLKFHFTPSYPLEAPEVLFLKPYIPIHPQDWSPVQTVAQVCLSIQSMLSSCTKKELPPDNDLYVRNANTSPKKTAWAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVV5</accession>
    <name>A0A8H7PVV5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_003939</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVV5"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="342"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="451"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="233"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2180151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="581" mass="64099" checksum="2577C5138FD943F8" modified="2022-01-19" version="1">MRQSSNNDPTQELMRLIEHIADIDLRDAIFQRTQQALRRHQQQIVALEKSNRDTNAAMADQQIKYEKAVREMQFFKKKYEKMSEANKLKAQRRRSYSTDSGSTYDPRPSIATDAQPPLPVQHRQAPQKNIPLHLDNTMRNTVEDSVHDPHVELKRRGDTVTPMLPHSPPASETSVYPSHMPTSPTISHRQRQRQPSLVSQVLSLDGTMTSTTTSSGSYEPYSPYNSALFSIEEPSEPVSATSQQNNAPSSNTPVVPPRRKKLSQSSNPPAIFNTGNPVNSSPEYHQKRLESLAFGGSDGFWDTISQNPPDGAVERLISNFLRRGGSPNTARQNASPNDGVREGFGLIHAAIQQQNASVLDLLLQHGANPNAITLSSAEEDKVSAGYLAASVGWVDGLHMLAQARADLVNSRGFGNRQRTALHGAVEKNHLQAAQVVTMYTEGVLTNIPDANGATPIHYASATGNQTILLYLLQECSAELIVYDVNYETPLHYAARRGKLDIISILVDKFQVDPNIYVPRKVGTPLDAAKTSGQKKVVEYLKSRGGTNAKKLDKKREEELAKEKPAHLAATLLKNGLLADSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWY9</accession>
    <name>A0A8H7PWY9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_009003</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWY9"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034074941" description="FAD-binding PCMH-type domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="60"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2181420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="493" mass="53373" checksum="FADAD2FDB0EAEAAF" modified="2022-01-19" version="1">MVRSSSVLAILSSLAILATTTSGAVTTSLENCLQKISGLEVVVAGDSSWTKAKQAFDLRFTYTPKAVVYPSTDSQVQAAVKCAAASSIPIAPRCGGHSYEGYSLGGADGFLIIDVTKMQTVTVDQSTETAWIGAGSKLGPAYLSLWQSGNYTIPGGTCPSVGVSGNALGGGYGLLGRKHSVLADNVVALKFVNAKGELLQVDASTNPDLFWALRGGGLGSYGVVTSFQFKIYQISSPVTAFEYSFPASSYKKVMQGLAAWSPSAPEEVTVELNWGASSFDLTGIYLGPKSNIPSVMNKWFSIIKPSSSDVKEMSMIQAILKFTYMGTTDIQALSLTTGPGPADSRYYAGKSLLFDKATFSDESIEIIHKWLPKYKQGYIIIDVWGGAVHNQPSTGPNAFVHRSQQYGIEFVSEWDKDKCGDCLTWLSGFFNEMLTQYKKEYTVVKAYQNYIDRTLPNWSSAYYADAFPRLVSIKKDIDPNNIFRNPQSIPVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXS2</accession>
    <name>A0A8H7PXS2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_007252</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXS2"/>
    <dbReference type="OrthoDB" id="5511599at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039297">
        <property type="entry name" value="COX7a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02238">
        <property type="entry name" value="COX7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2182322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="95" mass="10602" checksum="3AD5046D0E448DB1" modified="2022-01-19" version="1" fragment="single">ANNKLPCNIEISPTPSKMSLVNRPNNVIANQRYFQAPSNTLLFLRGPRDKFFAYTTFLVLGTGVLGSLWGAVKMAKVRLTLYIIASTHLRISLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXS7</accession>
    <name>A0A8H7PXS7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_008678</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXS7"/>
    <dbReference type="OrthoDB" id="10255570at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07993">
        <property type="entry name" value="LPLAT_DHAPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022284">
        <property type="entry name" value="GPAT/DHAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT/DHAPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041728">
        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563:SF17">
        <property type="entry name" value="DIHYDROXYACETONE PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="8">
        <location>
            <begin position="238"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="817"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2181096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="838" mass="95497" checksum="8531BC3D3415058C" modified="2022-01-19" version="1">MSSESASRAEDRLKRLMEQYREICLTENVPDNGPSMNLVTAGTGGSTYTQDEDDDTSPHRTEDYTLDEWSTGVQEHRNIVAREPRRIREDPVAFMMNGWRGYNNYIGSKFYYKGFSEEMKNKVLNSQEVQHAIDLLAERQAHLFVDTKQTGSAAADKKKVANLRRKRKQFKLELEAVATAIANKCFSRMDDIRLLRFFAFTINNILVRLYHQGIHIKESEWLELRRVALIAKQKKQSLILLPCHKSHIDYLVVSYVMFRLGLQIPHIVAGDNLDMPVVGTLLRGCGAFFIRREWGDDLLYKTIVEEYIATLLAGGYNLECFVEGTRSRLGKLLTPKFGILKIVLDAMLSGKATDCMMVPISIGYDKIIETSNYANELLGTPKEKESLWGLFSSSRLLQLKWGRVDVRVSKPFSLKDWVDQQVHIRQNFDVSLPDNKVVLLKSLGYKVLADINAISVVMPSALVGTVILTLRGRGVGRNELIRRVEWLRRIIINKGGNVAEFGDMPTGVIVDRATSILKDLIGERNAKEVIEPTFYGIKRFELSYYRNQVIHLFVEESIVCVALYTVIKRGGAKLQQRMQFDKLLDEITFISSLFKLDMIFKQGGVESNTLRTIRWLAENNVIEVTDDGWVGLTDAERACGRENYGKYHSGFEIKINAGYFLCFLIWPFVESYWLASVSLLALTPSVETNTDEPQWLDEKIFSNRTQNLGKTLYYQGDLSYLEAVNKETVKNAFSRYIEQNILLNRRFKTGKITSEVALHPDYVPTRGPNGAILPQGRLWELVERIGNFRREGKNRRDNATVSARTLRLADMVGQDNLPSIQEQKKRSKAEAASVGARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXZ1</accession>
    <name>A0A8H7PXZ1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_007240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXZ1"/>
    <dbReference type="OrthoDB" id="2123049at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2182313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="130" mass="14639" checksum="9EC6D4B9E9F0362B" modified="2022-01-19" version="1">MCAGDFTRPCTSESEKETYQQVALAGNNGIIYILENYKVTSFVHVDYSITRVLRYRPKSLPESSPDILICAGHCNEIRAYYYGELITTYGTQDWVHDMILGDIDGDGKDELVMGLLNQTIAVLKCSIEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PY52</accession>
    <name>A0A8H7PY52_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007347</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PY52"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21063">
        <property type="entry name" value="BTHB_FKBP25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043368">
        <property type="entry name" value="FKBP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041200">
        <property type="entry name" value="FKBP3_BTHB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46493">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46493:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18410">
        <property type="entry name" value="BTHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="3">
        <location>
            <begin position="132"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2182417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="229" mass="25591" checksum="91F348B3A92E43D4" modified="2022-01-19" version="1">MEPTREWTHAQLESDSVSKKDIVTFIQNNASAEPLTFLSQFLINNKLNGKLALVAKNSKREKLVDAYEQLYETKSFRGDEAVDAATLTKVVKSDETEEKGDKEDAPAEAEVVRFKKLDIMKKGNKTSFPRKGDMVGVWYTGTLEDGKVFDTNIGKKKPQPLKFKANMADSLVGTNRVIRGWDEALLTMSKGEKCKIFVEAPWAYGKKGIEGVIPPNANLIFEIELVSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYZ2</accession>
    <name>A0A8H7PYZ2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Domain of unknown function at the cortex 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYZ2"/>
    <dbReference type="OrthoDB" id="2119945at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013897">
        <property type="entry name" value="Duc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826:SF2">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08588">
        <property type="entry name" value="Duc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function at the cortex 1" evidence="2">
        <location>
            <begin position="9"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2182368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="276" mass="31402" checksum="994F282042BE77B1" modified="2022-01-19" version="1">MTTPFQNHRLQVRVGTSIDKLKKIVVNDDANPFELNSDAFKGRGVVRVRNFTGVNKAAASSSPYFDIYPDKFSIQLQGRFLVDTNADQIIFGNFFDAPLRLPPGTSIATKFAKWFDPAIELDLYADKPTAYSPLVVTMNSIDVKKLSDNLPSWPSPNGERIQEDAHLLKVTNGDRRKMLSTKSERQDIKISSDMVFSMDFYNPYLDFDKCAIQIPGFEISVLKYWDGQPLRYVAKMRDNSAIFFIIEFLLVEAQESDNNEKDEAENEDESLDNDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZC4</accession>
    <name>A0A8H7PZC4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_007136</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZC4"/>
    <dbReference type="OrthoDB" id="10261039at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2182209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="589" mass="65113" checksum="36ED552705A1CB7C" modified="2022-01-19" version="1">MLRVPRLQSTIRAVAPVSRTRTTLLVSKRFESTTVTEINKSGSSIGAKLTTATLLLTAGYSGAVYYALNNEPFHDTFTTYVPGGELVLDYIDEVQNNKDLQEYRRKARELTKQASDYANTAKDYSIKAKDATVDAYEYASDTIAKLTGSSEGAAAPTPGAPAPVKRKGTESLFASANPAEGVVSKPGKISLYTDDESKGEPAKVTTQLIKVNKIQSNEPSIVQLSAVVSELADILNNAGMAKQGNEFVASAQNQLNHLNQQFDKLRNEQNEVLSTVVQLSKRGDQLTSEFDKYATDAQGLLKKSGEEAVEKVKAKESELKEQFGKERALLNETFSSTLTTQLSQQQQAHQAELKEALIAQATQLQRQFVNEVKHRVEQERAGRLAKLDQITSRYQALEQHAVSNAEHIDHSRQTHKGHIAVRTLRDKLTAPHKQPFEAELEAVRRNTANLEIIQAALDTIPRELAQEGVDTIVDLADRFQIVAAEVRNVALVPQDGGLPSHVVSKVFGKMMFKKYGLVEGDDAEARLARAEYYLHEEDLENAARELNQLDGWPKKLATDWIKAARRHLEVKQALEIAETQILLSSLEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0H9</accession>
    <name>A0A8H7Q0H9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_006285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0H9"/>
    <dbReference type="OrthoDB" id="444135at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001209">
        <property type="entry name" value="PRK00175.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF16">
        <property type="entry name" value="SERINE O-SUCCINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="127"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2183280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="526" mass="58256" checksum="D9E2555C45F40FB5" modified="2022-01-19" version="1">MSLHHVTSRLAYGALRAQKRPVAVGMSRLFSSLSPLRQNSPAASDTGNNSTSFTSSNPPMAFPCIDKLESRTLSLDGGPEPSYDKVVTGYETFHYDSPFLLDHGGILPNFDIAYEAWGTLNEKKDNAILIHTGLSGSSHAKSHAKNMKPGWWENFIGPGAYIDTNKFYVICTNVIGGCYGSTGPSSIDSADGERYATRFPILTVWDMVRAQFLLLDSLGIKNLHASVGSSMGGMQSLAAAALYPDRINRLISISACARSHPYSIALRHTQRQVLMADPNWNKGFYYKGVPPHIGMKLAREIATISYRSGPEWELRFGRKRAQEGQSPALCPDFLIETYLDHQGERFCLQYDANSLLYVSKAMDMFDMSESAFMKLKSQRNQNEPLLQRLLERHSDIEKKSFANECRLETGNKSALEQHDESQAVKDVEKAKKTPLSTLATSDPVTQDLIQGMTNIKMPTLVLGVQSDILFPVWQQKEIAECLRASGNKNVTYYELDSMYGHDTFLIDGVSVGGAVKGHLELLDTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q124</accession>
    <name>A0A8H7Q124_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Edg1 TPR repeats region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q124"/>
    <dbReference type="OrthoDB" id="2290055at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056581">
        <property type="entry name" value="TPR_Edg1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24293">
        <property type="entry name" value="TPR_Edg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Edg1 TPR repeats region" evidence="1">
        <location>
            <begin position="514"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1250" mass="143408" checksum="1E3B516893213A55" modified="2022-01-19" version="1">MQHLLKADVEGVLEHVSNLDRSSSKESLSETVTSLIIQEVHRTGECMNKPDFCHQTHDLLFRAWQQNLGIYDPYAKFHHRNGLTTDEYYKLVDKLSLWNELAQTLYSLSPEHALDILHCLRISRPDSKLPLKCLAMYYTVCCSFPSQDIVQELLQHPPLNQLEGMSSLDSASIASILKSMCTILAKLNTHSHDYSKPHHPAYQDAAEQIPQIFSNIYETFKKLSFPHSSRISRRNKHMYRLFWTEFCRNPLSRLIGIVENDLLQTFLKESEDWGHVSQFNNAVEQPFGLEHQQPSMFDIDETLVKLDMPLSDAANKHLMAFVKIYGLINSNCPLETMQANESLNVQTSRAMDKQGHGILTTTEDTTVTQEYVNDCLLKIQHQSTGWISFLELVVDFQDLFWSYFDEDAHLYDLITKAIVTENLHWRFFKRLSHNVILHQQSEDFIELQCIQCLTGLLIAVFKAISNRDQRLAFRNQIIYSSYQNGNDRTGITYGSMELWSRKRILECTTELRITCNQIVEQSDISSDSNLTHNSNNTLIDSLCWLSMIMPYAVLKRLVLGCIDNKGQTSAVHSILQKLGELCSLKASSNEEPLLITVLNSQEVAESMSSLHNRRNYTDLICQWTMVETTYTNKDEDNKDRNEKGFNRLTPLLDIIEYFEWCLIPGLSKWVRLSSDEVALLPASLQLLHLTLSPIMEMKPHANLPLANDEQSKSNSTQNRSLDWLLHINVIQLISDLCALLALRNKLEDTQQSHELEVLSFLRFTDWEACMSSLDSLLHMLLPDLNVKAPTDNLRRILDHDGAQGSTTVLVDRYSGFDWSLQIKVYPLLNRIADHYGFEKMYISLPTGLLDFFNGVEPIFVADEADPRDKWTLLMLTCKSTTWIQDVMLKNLSLAEHFNTVSLHPYDNVGFVTGIYHALLPAKTLSVLPEFKRLLADFLGQVFNLSPIPQSIRDYKYGNESLNTLVKLLMKEDLQILYSILYSKMLLQTYTSISNYQYGQASSSMGEDEHDNEAVYFVSSIMRVIQSLQPWSSIHDNGITDMDSQPFPEYLNSVMPELHNVTNGQEVSSEAFETDWNKSSDSVENEFDAYLKATSNQEHSAANRTQFSTANNMQHIELLFPPESQYNLSKVSLSVITLFILSQIKDQFQVKKLRESIWIFMLQIVEGLSSDPRRRRLVQAAGKAGKASIKNWKKKTGVKHIVRCRPLLNDDQIALVRQSLTLLQDQQESHIIGQKLDVFYIANSKLPRYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q170</accession>
    <name>A0A8H7Q170_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q170"/>
    <dbReference type="OrthoDB" id="10321420at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="206" mass="22790" checksum="63F01D31A2EE29FE" modified="2022-01-19" version="1">MVRDRIHGWLSCCFGSLFGFLFIVVFAGGWIGTTVWGLYTTTEYIHEIQSVAATNCTILDATMDDDDDGSYWLIHASYMIPVQLGVPANTTKISILDGTDYNAHYSVNQTLSCWVSTINFNTVTLSPSHVDAGTIIGLIILILMAIPLFIGVLYVVFYGFGLVCTFLTSCFASLKRERRHSFETVVATESLQIDEGGYNLNNRSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1B6</accession>
    <name>A0A8H7Q1B6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF7593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_006248</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1B6"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056015">
        <property type="entry name" value="DUF7593"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24513">
        <property type="entry name" value="DUF7593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="263"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="296"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="329"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="395"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="428"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="461"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="653"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="686"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="719"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7593" evidence="5">
        <location>
            <begin position="939"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="512"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="568"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="835"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="890"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="586"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="631"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="841"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="894"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="909"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2183244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1151" mass="128465" checksum="013B6643A43FF5BC" modified="2022-01-19" version="1">MVPVLHKADHSINDTTPYPQSLRPEQIEDINNPKFLDEQHPKETVGKQHHQRSSSGHAFINMNKETTATHSRKERPSSLTFNHGIPEASRRYDASSSDDNHSQDDDHGLVDFSFIHRNSNDRKSVGKRRKTTSKQSSPPRRQPKLHMYASSDSDDSDNHSTGSHRSFMDRAKRINGKTTEDSKKSPESGRDHSNSPTSQKRRPGRPRKDVSRSSISKASPGADNSDSDDFMPNRRRRERQATSDSTASRSKHGAVDPNRTDKAGRTRLFSCTGTGNIERVKELIAMGASVNWRDNAGWTPLHEAALKGQAEVAKHLLECGADVNAYGFGNDTPLHDACSNVFSECVQILVDHGANINAKNNEGLTPVDVCEDDECREILSRKQKDLDRISVRDKAGRTSLHRACSAGHHEEALSLMKQGSNVNTKDNASWTPLHEAALNGYLDIVKSLVDNGAHLDPLGCDGSTPLHEASENGHADVVRYLLEASADRNIRNKKGQTAAQVCDDQSIEELFSADIKPRQSTPIETTTKRASNSHNNTATSISKSSSGSKPLSREEKKIQALMETFQKMEKRQAKKAKKRQIRHHDDEEDEEDEEDEEDDEAAAAASKEPEHRPKRLVRGRPRSASVSQSREPSEEPSTKKPVVKLDPKRKDTAGRTQLHKWAVRGDENAVRELLEAGANSNEKDNAGWTPLHEAALRGRLEVLKLLLQHGADPNALGADKDTPLHDAVENGHTDVVRVLLENGADANARNASNLDCIQIAKDNEDDDMLVLLKSVQKRNFAKASSAATKVEPSSDQDVAQLTVSKVSELPIKKTSENSDELDQYSYSKSIKKRRLVSAGDYRSRSQSQERKRSEDTLEKSHPSSKVKVERKLPQALAGGFDIFNVSPTPHRKTLSNSKYTPVSGSHSRNVPETEVKKIKQEPEDPPVPSTKKEAWPSLSHALQYLPLYTVHLQETKPFHERAFYVADVQVRLLLGIKNLFEQYPHLEKRMVNEREKERLWSPLAFMVSERCAQAVKPAGTARKEDMDVKMEKNYSSADIVRTKEQEKQRFLQTELFFVRLDQIISIIKKDYSHLSNNLITITLDIGYSPGNDAPRQENPSHVAKVVSTAQSEEESPTTPLPIKRPAYGLPAKFAMKMQKCGGLGHRRDVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1H2</accession>
    <name>A0A8H7Q1H2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calcipressin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1H2"/>
    <dbReference type="OrthoDB" id="17212at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008597">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300">
        <property type="entry name" value="CALCIPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300:SF14">
        <property type="entry name" value="PROTEIN SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2183585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31168" checksum="A144923AD80754AB" modified="2022-01-19" version="1">MSAQHDHPVHIVATNTITIPNIPKEFFACPQIFDDLRNCLLVYGQLHTFVAIKGFARIMAVFEATDSAMLAKSELDKTEIGWKCNQDDSSIHLISFGGEDDNQMTLDDGVNLFVLRLYYGQHTNINPDSATVLLQVPELEKNWLISPPGSPPVGWQQIREEPPNSTVLAHDLSHALLSLNDDIGDDFQLDPESANSPSLSSAKSSASGAPSSPVVYVISKEDAHDNEVPQITVQDWDGGVQHHSLDHYRKMHRKIAPTAIPPVSSELPAPSLEDRPSTPIPMSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q247</accession>
    <name>A0A8H7Q247_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_006306</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q247"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF5">
        <property type="entry name" value="3-HYDROXYBUTYRYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="7">
        <location>
            <begin position="6"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="187"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="4">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2183301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="30707" checksum="843CDEF3B3DAA9C1" modified="2022-01-19" version="1" fragment="single">HGIKRVGVIGSGQMGLGIAMVTANISRLPVVIMDVNKEQIDKGIKFMDKLLEKDVNKSKITSDHAQKTKDLVSTTQSLKDLADVDIVIEAASENVALKSALFTDLDKYCKPDAILATNTSSISITKIAAATARAEQVIGMHFMNPVPVMKLVEIIPGLATSDSVVQTTKELATSMGKTCTVVQDVPGFVANRLLMPYINEAVLLLENGWASAEDIDTTMKLGMNMPMGPLTLADFIGLDTCLAIMKVIHENTGDTKYRPSVLLQKYVDAGWVGKKGGRGFYKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2E0</accession>
    <name>A0A8H7Q2E0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_000480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. RimJ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2E0"/>
    <dbReference type="OrthoDB" id="64477at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF8">
        <property type="entry name" value="[RIBOSOMAL PROTEIN US5]-ALANINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2184571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="184" mass="20162" checksum="6F7D307F9D6887EF" modified="2022-01-19" version="1">MSGQLNIELKSETLPILLRVPGPSDAKALLEILNNPSNTEFDPHAGDGNLQLADIENIITRMCSSAAMDIPDRVNLVVVDTSLDNQVVGLGGFGHIATDGDERIGDAGIMLQPEARGKGYGVEAIKLTMKYAFDELKLNAVTLTMLKKNVAMWTLIEQKLKLQGTERESEFGTEKSYMVRAKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q346</accession>
    <name>A0A8H7Q346_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_000859</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q346"/>
    <dbReference type="OrthoDB" id="2443732at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034520903" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2184946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="24957" checksum="F699DBB3B501DDCE" modified="2022-01-19" version="1">MHPRLLTERLMAVILLSAVGAIASADYNMPLVERQFPPAGSSSSTLVGTSVPPIFSTTSSSFSSFTPIVTLTGTSSSFPTASLSLTSSVPSSSSIPPTSTIISSTSVVTTSSSLITTSSIAPSTSISYVYSSATPSQTAQPQNSGGSLSPNTTKIIIIVVCTVGGVLAIAAIGFVWRKFSRRRKDYGWDEDDFFGSPPPPPQHMSYQQPMGQQYNYQQHEDPFKRTLDQYHRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q379</accession>
    <name>A0A8H7Q379_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_001001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q379"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2185088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="92" mass="10816" checksum="4C45A75DE1CF06B5" modified="2022-01-19" version="1">MLSDNKVAHVPILTHQHRNNFICSHCQDRFSKKWKSPDGRQFHGILCRKKYGILWNRDTYATKKNAAEAQYPCYTEVQLLHGVESQRQDSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q643</accession>
    <name>A0A8H7Q643_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="9">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_002453</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="9"/>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q643"/>
    <dbReference type="OrthoDB" id="9215500at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000002">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF3">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE, LIVER FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="702"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2186015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="849" mass="97384" checksum="53E6E0B7281F2800" modified="2022-01-19" version="1" fragment="single">DQPKHHKRSFTGFTKEKLEEQLAQVPSETRQAWEKYTVPESNDVDSIARSIVHHTATTLARTPYNMDDFGGYQATAHSVRDKLIQDWNETQQYHTIKDPKRVYYLSLEFLLGRAMDNALLAQGIKEPYTEATKKLGFKIEDLLEEERDAALGNGGLGRLAACYMDSLATLDYPAWGYGLRYTYGIFQQKIVDGYQNEVPDYWLTYDNPWELPRLDISIEVPFYGYVSKYSDENGRTRHKWEAGEIVQAVAYDVPIPGFDTKNTINIRFWSSKPRKEFDLAYFNSGDYNRAVDDQKRAENITSVLYPNDNHMVGKELRLKQQYFWVCASLHDIIRRFKKTERPWSEFPDQVAIQLNDTHPTLAVPELMRVLVDLEGLEWDEAWDITNRTFGFTNHTVLPEALEKWSVPMLEHLLPRHMQIIFDINLYFLQTVEKRFPNDRDLLSTVSIIEESQPQSVRMAFLAAIASHKVNGVAALHSQIIKDTIFAPFVKVLGADRFTNKTNGITPRRWLHQANPDLSNLIAKKLGNFDFLKELSLLDGLAQYATDEAFQKEWMDIKYKNKVRLTNLIKERTGIEVNPHALFDIQVKRIHEYKRQFMNILGVIHRYSQLKKMNAAQRKEVVPRVVIFGGKAAPGYYIAKLVIKLINSVGDVVNNDKDIGDILKVVFIPDYNVSVAEVIIPANDISQHISTAGTEASGTSNMKFVLNGGLILGTVDGANIEIYEEIGDDQIFLFGARSEQVEDLRHVQRYRNVPMNPELQAVIHLIENGTFGDSHIFQPLINTITIGKDYYLISVDFSSYLESQELVDEAFKDKKSWAQKSILCTARMGKFSSDRAIKEYAEDIWNIDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6U4</accession>
    <name>A0A8H7Q6U4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6U4"/>
    <dbReference type="OrthoDB" id="10481956at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="906"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="771"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="845"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="906"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="927"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2186328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1038" mass="106596" checksum="393AC98F457FF211" modified="2022-01-19" version="1">MNRDRAEIDDLLQQSKDHSPATADPQRSKVGGSNIVDDSTWNEPSTQSSAYDSVDHGGSRWQAKEDLSSTGYGNSPAVPGAFPKDSKTSGYSSQTFGSDNKDLNSSAISSQPIENDYSPAQRDTNATMATQGNATTAISGPNGASSYPSTSMGRSGTETGDVSDTYGTGQFDKTDKTYEPTNTSTTGGMNTSSQSMSTTTGSGYATGQNMTTGTNTDYSTRQGLDSTGQGMSATGQGMGTTGQGMGTTGQSMDTTGQGMDTTGQGMDTTGQGIGASDQYRGATDSSIGATDQGLGTTDQTLGSDSNFKSTDQTKTDSSGTSTGAMAGGAAVGAGVAGAGAYAASKDKNQSSSRRESKIEKRLSSLFKRGSSKDKVHETNTNDHFAHGDQSVPGGNQDMYDQQNKGYITTDDRVTNMNRGDTLGSQGSNMDRNVTTAGAITGSGTDTYGYGQQGSDIDQNAAAVGTTTGFGTDTYGHGQSGSDIDRRQEAVGTTAGTGTATYGSGQQDTMGNMDSTGDKSPNKSKHNKAKTAAATGAGAGIGAKIGAMMRRRSSKDDSNLQQQESQGMSPQTNDLSQSGSNVYKTDQTTGAYGINQPSGMNQQGSSWDTSKSTGMNNQQKSDWDTNTTPTDKNNQGSNWNTNQSTDMNNQGSNWDTNQPTDINNQSADWNKSSGTGDMTNQSTGMAGPTPGAAVGGTAAGIDSRNEYDSTQNKEAFSTPGPYDPGNDPNTDADMDQSNKHSGSKTAAGVGAGAGLGALLGLGLGKKKKDSQKQQSAVENSNNHLQQSRDMIDNNAQGTGVSTPNYQEGVQGPLRAENAKLDSNYNNNVQGPQTAENANLDTNYNSGVQDTGVQDTGVQDTGVQGTGIGTGIAGAGAGAVVGAAAGHYAAGHQGTGVQGTGVQGTGVQGTGVQGTGVQGTGVQGTGTQDSMGNISPTNEKAGLGATSAGEGDDPTSNDATLVNDRPTGQPQQEEPAPPPFKPGIATKLLGWEMKLQGRYKMFIANLMKNENVKAEGMELVHKGNVVLGREPYYPSRDGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q7A8</accession>
    <name>A0A8H7Q7A8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_002499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q7A8"/>
    <dbReference type="OrthoDB" id="10265800at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325:SF31">
        <property type="entry name" value="GH22081P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PHOSPHOLIPASE B, PLB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2186061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="374" mass="41924" checksum="8A9C786A0A8A8FD4" modified="2022-01-19" version="1" fragment="single">MKSPFSPLSFSLEAIMHNKYLAAALSLLNFQQIPIHEPPSIAPYTNEWIHALEQMYNLFPHPSNTTTRDQCMFDVPTFNCTQFYWDDGVTQRDVWHLRPQDIKAVISIGDSISAGFGMLSARPPFANVWEYRGKVFSSGSDSNEYTIRNFLSTYSDTVGGPVGITVPLSRGKGLNSAISGAVVQTLDEEVTRLVHQLSHTQYNSVRDSWKLITVLIGANNLCGLCASPSTGLPQQATADEYEKHLRLALHRLRTEVKHAFVNLLALFSVSVVHDATRGNQYCEFVMDKSNMYICPCAQGTDEERKAADAMAEEYNRRMYKVAKEFEGYKDFAVVVQPGLTAFDVAKYKQAYFSGIDCFHPNLCANQIMAIALWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U6V7</accession>
    <name>A0A8H7U6V7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U6V7"/>
    <dbReference type="OrthoDB" id="2361547at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="214" mass="23130" checksum="1B821C8B90ECA188" modified="2022-01-19" version="1">MPPIFVSTSMEADQISSRDTISIDQKQPSIRSYGAPLGSVDTPPDSIHEKHLADSLPEPPEDYAPSASLQVHAGKDDESSLSEVDSAAAIRHKPWTSGHVPHMDNSGKSTPVHPPARRSDTDEKVQAWLKSTETPDDQSDSADNQSPPPPQQQRRRSTIQTLKSHLLHGKFGSGIGKLMNKNETGNSGDITADGGRQELDTLRNSETEARGLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7H6</accession>
    <name>A0A8H7U7H6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_004131</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCNDBP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7H6"/>
    <dbReference type="OrthoDB" id="41588at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.10">
        <property type="entry name" value="Talin, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026907">
        <property type="entry name" value="GCIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049317">
        <property type="entry name" value="GCIP-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049318">
        <property type="entry name" value="GCIP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492">
        <property type="entry name" value="CYCLIN D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492:SF1">
        <property type="entry name" value="CYCLIN-D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20936">
        <property type="entry name" value="GCIP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13324">
        <property type="entry name" value="GCIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like N-terminal" evidence="8">
        <location>
            <begin position="45"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like C-terminal" evidence="9">
        <location>
            <begin position="192"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2174111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="330" mass="37300" checksum="A46EFDF551FF6B72" modified="2022-01-19" version="1">MDAEAQVIIKGLETDLQNGIDHMDIDRSVHNPEFDTVKFKGTMANLGKILSADTTKLTLACKPPCKTTDMAAMVKGMQGTLRRITGFVDSIPLDAGKTYIEHIQKLVKYAFIEIISLCKSVAEAKDADKIDQILQSTGSVWEACKQFETHTAKDNREAVNRIWQTQTELIADAQEELKEFIDEQNEDSGDNDDDEDEDDGWGDIMSNGTKMTPVQLETCKKCQQAIKMTTMVFKKIQLRCIKVKPSSDDMEANAWLDKICKSGQLVSDRVDELASSFYEEDDDLKTYIESFVASALGLIDLVEAQVKEEEHIKWFQMCRKQYELLQIKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7H8</accession>
    <name>A0A8H7U7H8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_004146</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7H8"/>
    <dbReference type="OrthoDB" id="70823at2759"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000044">
        <property type="entry name" value="Deoxyribose-phosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="8">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001357-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2174126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="233" mass="25134" checksum="47570923EF51E2E4" modified="2022-01-19" version="1">MISVETLSYQQLAKVFDHAILKPEQTKDDVVTGCELAKKYDVKSVCVKPCDVKQASELLAGSDVLVGTVISFPHGNSPTSAKVAESLQAVEDGAIELDVVLNIGHLKSGSHDEVENELREVITKSKAKNPKVIFKIIFENAYLTKEEIATACKISERAGAEFVKTSTGFAKSGHTIEDLKLMRQNVSSHIEVKASGGIKTLDQVVAILNTGTTRCGSSSTDQILEEFKKAKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7I4</accession>
    <name>A0A8H7U7I4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_004191</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7I4"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="6">
        <location>
            <begin position="208"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2174171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="354" mass="39701" checksum="EC1CEF51245A818B" modified="2022-01-19" version="1">MNNRATLDWMRHVDHALGPIKLKSGQTSMHWPFFVGANTFSRLHTNIMPSNPPPTSALLQLLVIRTSTMERNHTSCPSTLSVMLNGVTLKFGAKSHNSGKAKSAHMNFAITGDGVMDISRLIVKGKNVLLVKRDSKAIEDVHMSIETYIVENQENVSARVKEHCIPEKTWKSMLKRLLSTGDTTSAPSPQSKLTGSLVLSRHNNTDDVNDLLAISQSVFRISTRCPITLRVMRQPIRGSDCKHYECFELDSYLLVNRGLAPWKCPHCNNTSTPEKLVYDTFLEKMFATLPSNVAAIEFRKDDTVEDGFSRKVIYDKVMDEPFIKPTKNAQNTNKQTLNTNGSHQPSFTIVEIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U899</accession>
    <name>A0A8H7U899_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">INT43_008077</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U899"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF7">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="756"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="441"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="963"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="462"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="594"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2171697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1098" mass="120990" checksum="9E6C47815BA76ECD" modified="2022-01-19" version="1">MALQLSSYHTSLIAASPTLLPENVASFITAVSVATRLSLRCSSLFIEALLESARYSTAFSLGMSRQTLIAALSTAKRLHMIRFSENPDEEIKEARGGFLQVLDKYTNLGVYIVHHTFTLAELFAMTGFHLTTQTIKTGFRTAEESVRILDGIFGSNETSRAIASLVALVHRELMLDPDFKLSKKGKIAILTGLTRAMTSFAVLQNVTHNRMMSHMQMTVVWEGLVIEEEEDEATSVEVPDGRRALKDSGSDDPDNPIMQHPDIIHELEGILAQDEASAELKVAAPANSQEEINAIDSAYSSPSKSAYDADVYEITTTTKTYTTKTTSFRPLNPHQQGETENPEPAPAKYVIVKSDEETQESFVAIVDRENDQFVNADKNNAIDQINSSKLLSNVNHDSGAELRTARGFRVMLSAMSKKFNKKKIERQERYAAANLHKQIAEESSAGNKPANHNSPGQVVGPTTTLTSTSTTTRSTSAQYHERPLKAPAVPPKDSLYSDDDDDRKKEKNNWGKFKRKAVAKNKSVSNMFQKANGSGMLASDKKKVPSSPSGSTPPPVPSKQDMKPAVRGHTRLPSNQNVPPIPTLSTSSRRRPRSNSISSLASIQSVARTTTTTTFTSSAGTTGPSSPILKRMPSTQVRGALTKRGAGTYPLSDKSTRRNFPRAHLITNIARFMRYASAAYGESFMRILGIGDMPHILPASHHHHPNHHAFSYHTSVPVEDILLSSYTDSTLLSIQNPQINALVHYVTVDHAAEAVVLTCRGTLGLSDILTDLTCSYSGFTLPQTGPGGEERHFSAHGGMLGAAQLLAKQKGKVYRVIRDALDRWPTYGLVLCGHSLGAGVASLLSVLWSQMRDEFAESEGELYTRALSGFPAQDTIPFVTNVESGLPPGRPIHCYTFGPPCVMSIELSQYCGQGLVTSVIHSYDIVSSLSLGLLKDFKNVAVSLHDESNITDEIVSRVVGRYQKSGTSTQEGEPDKTDEEHQPDDDEQWFWALIKTMRADMTSEKLYPPSTIYHIESIPQLVQHTDGRTESFYAKKRTAQSKRAHTVILKKCENVQQRFSEIIFSRSMFLDHSPNNYETAIRQLCRGYFGEYEAYENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U985</accession>
    <name>A0A8H7U985_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thiol methyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_009119</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U985"/>
    <dbReference type="OrthoDB" id="276151at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183:SF11">
        <property type="entry name" value="THIOL METHYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51585">
        <property type="entry name" value="SAM_MT_TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2171458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="25412" checksum="88B7D22D908C35F4" modified="2022-01-19" version="1" fragment="single">WYNGATVVSPKRSFPHVINLQTVNPALDTNWEKRWHDKDTPWDHGESSQALVELLKEKQDVIPKEGNVLVPGCGRGYDVFLLASPERKVLGLDLSETCIQQCLKLQKEKQLSDAHISFICDDFFKFDVPVGKFSLIFDYTFFCALPPALRPQWGQRMAEIVKSDGVLICLIYPLVEREGGPPFSVTVDAYKEALEPAFENLYLADCQGHASRAGKEKISIWRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9C6</accession>
    <name>A0A8H7U9C6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho GDP-dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_007813</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9C6"/>
    <dbReference type="OrthoDB" id="1683373at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000001">
        <property type="entry name" value="Rho GDP-dissociation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00492">
        <property type="entry name" value="RHOGDI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2177156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="196" mass="22050" checksum="A43EE8C904EF0237" modified="2022-01-19" version="1">MADHHEEDELAPTQTAGYKVGEKKTMEEYQNLDANDESLKKWKQSLGLGGAAAPGPSDDPRKVVVLGIALEVAGRPDVSVDLSTKDALEKSKSQPFTIKEGVEYRMKVKFKIQHDVVSGLKYLQVVKRKGIKVDKTEEMIGSYGPNPEAYEKKFQSEEAPSGMLARGHYEAKSKFIDDDNVTHMEWTWSFDIKKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9E2</accession>
    <name>A0A8H7U9E2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9E2"/>
    <dbReference type="OrthoDB" id="5279943at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="293" mass="33515" checksum="2D1E82AB8FBAAE95" modified="2022-01-19" version="1">MASDHNTLYASPVNAYPEDEQWQGRKGRSNSKLVDIRGRAVGDSVLVALLERPRDMEDLIARNTEFFEAIEHHIRETQGEDAWKEFKQVLLSPRESIPDGAWLDMLIPRLEANPSFIAKFYEMVGYDEYESDSEPEDEAENRAANVPSMPPTAAYDSDSDEEESVELSAVREFPEIQQRLPDIFPPFFRKVRHCLSQGCTSDAVNMSARRNSVQADCLTEDVDVDVAEVRHQHINVDAEGDYDRFIGILQTTRREQPDDNKWQDDVSECLDGWPDLLEELRDIISDVHNAPQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9Y9</accession>
    <name>A0A8H7U9Y9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_003048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9Y9"/>
    <dbReference type="OrthoDB" id="2408098at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2177801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="234" mass="27462" checksum="8F528825FF29B85C" modified="2022-01-19" version="1">MFEGLLPVPTFEDLLLPQCTTDDWLTAVDLDNLDAPNNVKSLIAKMQEVQHIYLMGHTNVDGFMDTFLRILRFDDYPCCLNWFCEKYEDYSFYNPCGYSIIMIHGRHHKYLTVLDGSVIVDADYSNRWREERVLLTTAKTMREIWKKHKDTGSPIYTYVIRVVGTQFTFYKATAYKPYVPELEWMPPYSNWLTMQRHPPVVDSVHLNAYDVCNLEDRRAILTGMASIRKFLTDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAF6</accession>
    <name>A0A8H7UAF6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_000080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAF6"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="7">
        <location>
            <begin position="44"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2172733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="296" mass="32488" checksum="56770FF92407C4EF" modified="2022-01-19" version="1">MAQQAKQAAQRLGGMFPKGSGKGIGGAAGAIITLGALGYGINASLFNVDGGHRAIKYTRLFGVQNKIYNEGTHFVVPWFETPIIYDVRAKPRNVASLTGTKDLQMVNITCRVLSKPRVDQLATVYRTLGQDYDERVLPSIVNEVLKSVVAQFNASQLITQRERVSRLVRENLVRRALRFNIVLDDVSITHVGFSPGFEGAVEAKQIAQQDAQRAAFVVDKARQEKQSIIVRAQGEAKSAELIGEAIKNKPGFLDLKRIDTAREISQVIARSGNRVMLDSDTLLLNVNADKKSAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAM9</accession>
    <name>A0A8H7UAM9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_000036</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAM9"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13983">
        <property type="entry name" value="STKc_WNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000058">
        <property type="entry name" value="Mitochondrial arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="716"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="621"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1081"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="631"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2172689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1251" mass="141518" checksum="BD600EF5FB351EF1" modified="2022-01-19" version="1">MASRVFKNAIASQLSRITGIKETILNSAIEVPKSRTHGQFAIPLPKLSSMTGRSQGSPVEWAGQLATKFEGDTFITRATALGPFLNFSVQPTEYIRHTLIDVHNLKDKYGMSPNVGRGKSVTIDYSSPNIAKPFHAGHLRSTILGNFVKQIHLAMGYNVTGINYLGDWGKQYGLLAVGFEKYGDESLLEKDPIHHLYDVYVKINRDTKDPAVDRQANLYFKRMENGDEQVLSQWRRFRDLSIASYKDIYSRLNIEFEQYSGESQVSEYIPQIYQLLHSKNLVVEQEDGSLVVDLEKYQLGKPVLQRSDGTSLYITRDLASYMMRLQKYAFDRAVYVVGTEQSQYLKQVFKITELLFTTDNKERLHVPFGRIHGMSTRKGTVVFLQDILDTAKSSMLDIMKENDEKYQSMLQDANSDVDHIADIVGASAVLVQDLAAKRIKDYHFSWKRMTDARGDTGVYLQYAHARLCGIERKSDTPIVADSDVSLLKEQDCMELAVIISQYPDMVKTAFDTLEPCTIVQYLFQLSHAISSANNHLRVKDVPPELAKARMSLFWAAKTTLANGMRLLGITPVERILVIWPTRLTSTPYHNNAQSQYRTFKESDTYLQRNMDIAQQSAEHTMPSSAPTMNRLDSPLQLSSSSSLQHNVPLEEDLNGKANANLAAQLATQFARYNNSTKPTYYPTDEYTMSTSNDVIDRSTYHNVEKVIEVGPNGRYARLNTLLGKGAYKIVYKGIDREEGYEVAWNIFSQPATTDNQDLSHEIEILKSVRHPNIIAFHDAWSTNNEFVFITELMTSGTLRDYIRKLSLPNNKIVKRWSRQILKGLVYLHSHEPPIIHRDIKCDNIFINGAHGEVKIGDLGTAQENSPLMSSAKRYTVIGTPEFMAPEMYEEKGYSEKVDIYAFGMCLLEMVTGEYPYGECKNAAQIYKKVIQNIKPECLSKVQDEEVLALVNSCLSPEQERLGVILELLMSAQEILEHSFLAVEPEVVLVGTDNTKKHLHLLVVFKGMEKLSVKFEFNADTDTADEVVSEMIEEQVLPQRYQQLITGEINRILRDMSKDSGAQDQNAARLVWRREYDYQSELEHTRMEIAKAEDRALEAQKRCEELELQASIVEERFTDTVRKMSTLETEEHMDSPVETGSTHAVLMEHVLAKYADEDSIEGLVLDAATATNRGRDKATEWVHKLHDQDIMTVGDLRGLHDEDWAGLGLTVFALRALKNTLKGKRPSVRSNSISDIEVPGSIEDMSSAVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAZ7</accession>
    <name>A0A8H7UAZ7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_005459</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAZ7"/>
    <dbReference type="OrthoDB" id="40048at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006849">
        <property type="entry name" value="Elp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056169">
        <property type="entry name" value="HB_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056166">
        <property type="entry name" value="TPR_ELP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23936">
        <property type="entry name" value="HB_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23878">
        <property type="entry name" value="TPR_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELP1 TPR" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 three-helical bundle" evidence="3">
        <location>
            <begin position="130"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2176225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="348" mass="40018" checksum="755FD347E031D516" modified="2022-01-19" version="1" fragment="single">RTQYDEAAIAYTLAGANQDALDAYCLGNSWKEALSIAKQLQYSEDAISDLAYSLIESLKEKRRYNEAARVALDYTKVKVFAQKIQVQKFFFLYNSKFVLHQDVENAVESLIRGNHWSESVRVSHSFGRADLIETHIKPGLAETFSQHKDDIKDMQEQFEKQITRLRELREKKPDAYMNMPDDPTLENVDMFSDTTSMYSQFTRYTSTTAQMSQASARSSTNFAQFNSRSSKNKRREERKKNSGRKGTIYEEEYLVSSLKRLYERAYAMQTEIGEISKSLVVYGYMEEAKAIQKQFLVLLEKLSEAIDGIFVPLQLQQPPNDDGVIPPPTVIEKPSMVAVKWKLELLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UB63</accession>
    <name>A0A8H7UB63_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-phosphofructo-2-kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_004588</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UB63"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF32">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="4">
        <location>
            <begin position="85"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2173214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="544" mass="62325" checksum="1C51C77629CABC22" modified="2022-01-19" version="1">MPDDSDPMHDQQPNDDQKRPEVQSYPASPPPTAEQQTSFFAGRASIGLDVPGAVQTRLPPDPNERQMDSKLVVVMDIGADIPFCRAQVFNVGNRRRVNAEKTGKSSGKNQDQSASFFDPNNADGKALRDELALETLTELIDWLKAGGRVAIHDATNSTRERRAKLLDRLSQEPEIKVLLLESVCTDKLVLERNMRLKLSGPDYKDKDPAVALKDFKSRVANYERAYEPIGEWEEERDVQFCKIINVGKKVIAYNISGYLSGQAVFYLMNFNLAERQIFLTRHGESTDNIVDRIGGDAPLSALGQKFGTALAKFIDRQRQAFEETRKKDKMEEIKQFEQFEAADEELEGGTSLTKSLSETNHKQCQQTQGRFVIWTSMLQRAVQTVESFNAAEYDIKVNIFDSLTKYILALTISFVVFQLREGMSYYEIQRQYPEEFAARQANKLYYRYPGIGGESYTVYSVAPDVIHRLQSMIIELERMTQSCLIVTHRVVMRILLGYLLDWTHDEMPHMDVPIHTVYELRPKPYGTELKKWQYNPEKDDFFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBU9</accession>
    <name>A0A8H7UBU9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007842</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBU9"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="174"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="192"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="271"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2177185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="313" mass="34190" checksum="4EEE340785D78644" modified="2022-01-19" version="1">MAGEDAYAYQENRENVNHLDASGIKRQANDSLEEGKTKTRRTSGEEEDLGDSDKENDMKDDMNEGADNHGDDDSSISSQLPMLTAEQQQQLLQTYAQASGQDLAHLTASSLAQAMVSPIAVPGLTTSLLQSLQGGSVITSLPGPPHLTGNIRHDGTGEDDSDKRVNSTRNLTNDERRQRRLFRNRVAAKECRKKKKASIQNMEERIAQLQDENDRLHKELEEVNAKVSLGAMQGSDSYRLMKEVEELNAKLGLSQMANAGHALTAAVVAAAASAHHQQQQGGESSAEQQKFAQQLQQQLAERSNANEASKSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UC05</accession>
    <name>A0A8H7UC05_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase family 32 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UC05"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46830:SF2">
        <property type="entry name" value="ALPHA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46830">
        <property type="entry name" value="TRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="583"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="620"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2174353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="643" mass="72737" checksum="B3A1D60F6DCA2366" modified="2022-01-19" version="1" fragment="single">AIVGPADTTVISDSSSNNQDASNTISVDANTQAEISTAMKAEIEPMSQTKIPKIVHFVYGMRDENPQLDLIQYLSIKSAQEIINPEKIYLHYHYLPTGEWFDLIRPLLTLRQVDIPTKIFGNRVDHYAHRADVVRLEALKEFGGIYLDLDVIMMKSIDHLLDEEFAMGQEGIGGWSGLCNAVLLSRANAPFLQRWYETYRHFNQKDWNHHSVLLPRLLAAKFGSEIRQLNYDAFFWPLWDKNGLRQLYLEKSYDFANNLGVHLWESAANKNLIKGITPGVIQEVDTSINCALRRFLPNQSATRDGACKIIKDTTAGDGLVGNWPVSPPPTGNPTINPFRIDEVSGNHLSGLARNAEFKTVPDHEESLLYLNGKDSYIFLPMPTETSMDTVTVSWRMTVPKGYKKRYGTAMMIQSDLLKVYVQTQTTTLDMTHNGIYVLNGIIPNLSENLGLGVRTIQIADYSAADATVRSNLNVDPSPVEVNDGQEHHYALTINAKEGRLIVYQDGYVLMSNAQWRPPVDNNHEKDIVRGIWFGSPEPEESNYQDEWDTKHSLAGWWRRIQVWNRELSPEQIVDIARTSTRDLATTNSEQQHEPLSANLDTGLNEPVDHSIEDSIIDQVDEVDDGVEEIDNDPIEMENDWLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCX4</accession>
    <name>A0A8H7UCX4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCX4"/>
    <dbReference type="OrthoDB" id="2220024at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="128" mass="14270" checksum="EBFA8202F8F6AB67" modified="2022-01-19" version="1">MPVKATEEYRVALMSLLSQLSELERLGNDFFRKIENTFSSSYSVSEAKTDYQQITDILQQLENNARSSGLLSLSDNAPEEGKQEQPPPAKSLATRNSETMQAVEQNFTEQSRLVSNVQAAINTSSHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UD55</accession>
    <name>A0A8H7UD55_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WDR59/RTC1-like RING zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_007859</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UD55"/>
    <dbReference type="OrthoDB" id="60955at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16693">
        <property type="entry name" value="mRING-H2-C3H3C2_WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037590">
        <property type="entry name" value="WDR24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049566">
        <property type="entry name" value="WDR59_RTC1-like_RING_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17120">
        <property type="entry name" value="zf-RING_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="153"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="243"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="WDR59/RTC1-like RING zinc finger" evidence="8">
        <location>
            <begin position="678"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="530"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="530"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2177202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="735" mass="82090" checksum="502839526AA83032" modified="2022-01-19" version="1">MPANSRGPLQFATQTALNASRLSSDSTIGTNTTVTSQQDGNDNVTFYDSPTSPPYQAIKYQLPGALNALSSSPDGEYVVVAGREVLKVLHVTDQEATEYINLRTGSNLSLNYSSNDVKWGNNGTRNKIATAATNGAIIIWDLNKSGRKTDRVISEHSRAVNRVCFQPNNGYILLSASQDGNIKAWDLRDPKAAAKYSYEGKSESVRDVQFNPMHTHEFAAGFETGTIQKWDMRNPKLIYERKVSAHNGPCLTVDWHPDGRTLASGGRDRTIKVWDMNSDSRKPQYTIRTMASVSRIQWRPGYDNEIASCALLSDNGLHVWDVRRPNIAKYTFDEHSTTPTGFQWLSPDVVISCAKDRYFMRHEIVGAYKPIELLRKNGIGWNIHGDLVFSIDKSTGHQFVDEASTPGLTNQASRKSSRNRTTTGEELSLQYIPPQTCGIAHLPLFDYGTFSVFAQNYVINGENLKLACETNAKIAWSMQRFRAAQTWKIVQLLFADVEEERDSEQANGIDENYHNMSVTKALTANGNEVISESDSESSVSPVNEDEKDNEEASSSDSSESLESPIISQNQEIINDLFHYYTEQSDVQMCVTLYLIVQQYVHINADQLEDWFTSYIDLLRRFKLWTSATDIINACPIDNVRALNLNATTINITCNNCFKLVLGTAQGSWACDKCHKLLNPCSVCHQTVRGLYVWCQGCNHGGHLGHMRDWFSMKSQCPTGCGHTCTLDMSTQGSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UD76</accession>
    <name>A0A8H7UD76_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_005724</name>
        <name evidence="7" type="ORF">INT43_007919</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UD76"/>
    <dbReference type="OrthoDB" id="2389564at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650:SF15">
        <property type="entry name" value="RIBOSOMAL PROTEIN S30, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2176484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2177262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="65" mass="7088" checksum="11B5CEDF5C118BD5" modified="2022-01-19" version="1">MGKVHGSLARAGKVKSQTPKVAKQEKKKPVVGRAKKRIIYNRRFVNVTSTFGGKRKMNPAPTAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UD90</accession>
    <name>A0A8H7UD90_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_008939</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MEF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UD90"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF534">
        <property type="entry name" value="MYOCYTE-SPECIFIC ENHANCER FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="385"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2181356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="468" mass="51794" checksum="DE788A9E0EAB8189" modified="2022-01-19" version="1">MGRKKIKIQPIKDDRNKQVTFLKRKYGLMKKAYELSVLCDCEIALIIFNSNNKLVQYASTEIDKILMKYTEYSEPHESRSNQDFANLSESGTSKDDDDATPPPESDFDQLHPPAAVAPDNRQRKSSSQQPPPSHPGHSPMPSHPAAVSPYHRPVQPPAGYPSSLPPPFPPTSMSPSPGYDMYSVPPHPNMYMMQHQMPPQIMHPQYPQQPMPPSSQHPMYQQSSSYSQPYYQQQQHQHPPPHQGLPPPQHHSSPHPPLPTPQQYQGSPQPVHQRVISPVPPHNGTPVSSSRTPSETGAGGPGSPSISSPKIESPGSNSKRPKLRVQIPSETASSSDKPQPLENEEVITRKGEDAMLPISSQPSSAIRSAGPNTEPGPASALPSEFAQNLPSPSTFYPEFYQQSELPSPLNFSATPRDSGRAFHWPAPGRDYKPSPLAKLDSNKQLDPGKRGREEEVYDHDEENKRAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDA8</accession>
    <name>A0A8H7UDA8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_001365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDA8"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="39"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="146"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="524"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2175718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="624" mass="68118" checksum="303B3F43BAE82FD3" modified="2022-01-19" version="1">MGKVVTILMKFRKTVGTAKDVKTMLNLVKRYSLAHITLHIRIVCCPKQTGALKRTTAPTRYMHVVCAQWSKNIDSEDEPYNFNNQDLDKYTCYICKKKQGLCVQCEHSGCTRNFHITCALNQSLLKPSKNIPEDYQLLCSSHATVKEEESSDDDLGSVRSKSRSNSRPKKLQARGRKVESDDDEDEDDDDNSKQDSDESEASEKAQSTASSDMSLDTEKSGSLTPHRLPAKKRKLTPNNRRNGDLDLFKDDHSESNDDEDDDDDLGTRGSSSNKSANNGHRNSLVAAAKSMSLQEMMRNKRKRADMEKSKGLQGLKPANTGLSMDNAVTTTNKPVVPPAASSTTQAPVKNKLPKNGMGLASNPGLGLATNRPNTSSPGPTQPVTTATLKKPSISAASGGNAPAPLDFDTLQNDIRGGAHKWGAGGQAAPPALLSPGSNQTMADIINTPGSNPGTPRFGENNKKLQLGASVRKSDSPAAADYSDLVGTMKGTIQDMMEGMLTKLQSSQITSNGAAAPNPDQLNQIIHLQTQLRSAESEIYRLREQQRAEIESCKRESDRTHRQFKANVLAIFEALGCKIPGMQASPENIEEYVQELRNLVVSAKVDERERDRVLQKVLAEVDNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDG7</accession>
    <name>A0A8H7UDG7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dynein axonemal assembly factor 5 TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDG7"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052623">
        <property type="entry name" value="DAAF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057978">
        <property type="entry name" value="TPR_DAAF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16216">
        <property type="entry name" value="DYNEIN ASSEMBLY FACTOR 5, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16216:SF2">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25757">
        <property type="entry name" value="TPR_DNAAF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein axonemal assembly factor 5 TPR repeats" evidence="1">
        <location>
            <begin position="25"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="888" mass="99090" checksum="A6E00DD9446D665F" modified="2022-01-19" version="1">MSVDITDALNILQPSLSILQDAKSVDRSAKRRAIQTVRDESLKRLDTPEAIHTFLKNTLNLFVGCIAHDNVEKCREQCLELLYELLQKVIDTSFAVNDTISLCKERVCVNGNMRTPAEESEEIRHGIMRLLNLVLTKCSSNTIKATTADDIVSIVQNGIKDRYPEVQRESCSILLTLAAMKSTYIGYGADKISEVVIPILRHKHAALRTLGVKVSKHIVLVNSAALKPLVRSPNEDEKSIMELLTFDHSAAVREALSDCIHQWLILSSPIERYTLAGDLLPVLMALAVDEIETVRKNGLKSLDEVDLVCLKDMEEAGILQEYKSSLQTSDKNLGLSYIIHHTFISGLKSISHTLCLPFHQNRGTSLKALKMYVEYASQSDVIPQLRTILVMLSTVKSVEKDSKLIEGIIAAISSKIPDATFYLDILLPFANNPAIQEKGLSSSTALWLLSMLFQFSSPNAVSLNTLNRVLDFLKCAPTTRKLVDQVLNVTDACAVLCHSITKYAERVDEVLSDALRYKVITIGTQFLAINSINTESHKDGISLNNFSFSSPNLFPEQMVFSTFRALQHPAQEISAIYAHYLPTILEGLRLSRSEPPEQWNDNSVNMRMVEIMLDHINSQALEEVGVPEQLVEILVRAGSMASKSGNSRETDSSCIRTRIRSVQCCIKLYSLDLDAYLFQRYFAYIFNGLLMPCFAISEPHTGASTLAVQDRLRQQTTVCLKAAISIGASVLTEEEMTLSQKTLVENLHHSDERTRELTIAALITLMEHYHSFGQNIDAEVEKECLSALLERFHDEKKSVRMCLYNSISPLLPLLSDQGKNSTTSALVNQVELSNMQGDKQALMAIRQLLKVAYDETGNAVLEIIAEKQALSKTPELYSSFIEHLQHND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDV1</accession>
    <name>A0A8H7UDV1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_005522</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDV1"/>
    <dbReference type="OrthoDB" id="2320368at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2176288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="31959" checksum="FA5F05D0AAF3A835" modified="2022-01-19" version="1">MSLAALKTACRRTPTPILASTQLWRSLATQPVRNVANREQQLESLIPTSNDLQAVKRNRPTAQAVTSHNLTISKLLAAGLHLGHSTSLWNPATLPFIFGTRAGISIINLEHTLVYLRRACNVVREVAQRGGTVLFVGTRPEISELTIDAARVSEGYHVSGKWTPGTLTNAHQVLGRHATPDPQDPGKPPKTYKPDIMILFNPLENDIAIAEAQLNNIPTIAITDSDCDPRRVTYPIPANDDSIRGVELVAKVLATSAREGVIKRKQLLDRKEKSSKASRDYRNQFDGRSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDZ3</accession>
    <name>A0A8H7UDZ3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_003310</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDZ3"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005469">
        <property type="term" value="F:succinate:fumarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF2">
        <property type="entry name" value="SUCCINATE_FUMARATE MITOCHONDRIAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="8"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="105"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="208"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2178057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="297" mass="32590" checksum="A9FE0BE77DF91FCA" modified="2022-01-19" version="1">MSTQSKNKSVLNSTIAGAGAGAVEVLLMQPTDVIKTRFQSVRAASMYTEGIWKAFTKVVRDEGFSALYRGTVPVLCIVGPRVSLQYMGLAMYKPMFEKLEGKVLPAHSSAGLAGVCTGITQAVTLVTPLEAIKVRQQTDLMNAAHQRKYHGIAQTAGLIVKNEGFLALYNGLLPTVVRQSWGLLVKFSGYIEIKAIFEATSKDPTQPLAPWKHMVSGGLANVLVAVLNSPPDVVKTRMQDEGSAHRNTWQCVKTMAREEGLRSFFRGSWLRVIRVAPGGAIQFAMYEKLSHWLENRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEJ4</accession>
    <name>A0A8H7UEJ4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_005739</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEJ4"/>
    <dbReference type="OrthoDB" id="2282627at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="332"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2176499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="60501" checksum="8517952B51AB67AE" modified="2022-01-19" version="1">MYNKSISPLGAHDADIPDLTFSSQFEFEVITQLNVICNSISIVCGMIVLTITAALRIYNKKLVDRVSLRLNAAVSATDVVNSIALLIYTFEDEEGNSCKFSAFLIIWLSNQYIFLTTAIAFNLQWLFLHNRSLGNLEIWYFVCAIGFALLTAIIPLAAGKLGFDQAQTYCWYTPSYTRQTQGFEWGTYIAPQLACLIYCLVVVVIVAIKLKRDKQALDRQLRTPWMGNDWQKDPAYQMEARLRKNQRSINRVVRRILLYPLVPIITQTGFIASEIWMYRHLEANFALNVWGVSLKALPGFFNLIAFSVDPAIYNVAMTIINDLIVKYGDQPKSSGPHNSLDEAARRRPVDSDGVNENMSEPPIASYQTESTYNETPPTTKGRRVMRWIVRNWLVPAARGQNSFIQASSSDEQEPQADIEQQDYEHKEAAPNEIPHMATGIAELGESSVHPATMTLGTSVGSETTAISRPMSDASYLTAMPVAVPSHSGSQSGASSIVVDAVSRQSHPTIGSTLYTVSTPTSSQMTPRHRRLTITGREMYREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEQ9</accession>
    <name>A0A8H7UEQ9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_001759</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in the regulation of membrane traffic through the trans-Golgi network.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEQ9"/>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14235">
        <property type="entry name" value="GAT_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16998">
        <property type="entry name" value="VHS_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000008">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000024">
        <property type="entry name" value="VHS domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052653">
        <property type="entry name" value="ARF-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="7">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="9">
        <location>
            <begin position="186"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="GAE" evidence="8">
        <location>
            <begin position="477"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="426"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2178912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="596" mass="66117" checksum="17C583309B0CC8E9" modified="2022-01-19" version="1" fragment="single">GACAATRYEPDLSLNLEICEMINKKQGNTPREAAMSIVRLVNSRHLNVAMLALTLLDNCVKNCGYPFHLQIATKEFLNELVRKFPERPAVCFCISLTTHALHPLTKHIFQPFPNPVTQRILSMIKEWKIALAEMSRHKDDLVHIKDMYRLLRFKGYRFPETREASVAALAPSQSLKSPEELEAEDRIAQSAKLQELIRRGRPQDLVEANHLMKIMSGYDLRQKPNYKQQAAEELTRIQEKVILLNEMLLSLNPGDKVDNDDTIVVCAHELKNACINAQPKIQKFVTEEEDSESIEKLLTLNDMINNVTAKFADIRKGIFDTHYEVNGTQPQQTNSSEPPKQAISLIDFDDEAPKPSTGTASAQPNQTKVASGNLMDELDGLFGPSTKISTPTSTTSASMDLFDLTAPMGSMSLDTSSRIPQQQHLAPISPGARPISNASPSPSLLPDSTFGSPMTNAANINTSSPVTLGQAPNTSTETQAAITFLEKNGLKIVFNPSHSNGVTHYEALFSNSSTAPMEKIMFQLAAPKVRLCRVHSMQLQMEPQSSETIPASSQNSVKQKIHVKNSNNEAVRLKYKVTYVQHGVDMEQIGQWSSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UF00</accession>
    <name>A0A8H7UF00_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UF00"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="160" mass="18857" checksum="13DB9C1757F9AA3A" modified="2022-01-19" version="1">MQFDVLRCLCGQQWILRTTCIPTLLLAVLSYFVLPDLPESSKFLTDREHAILHRLRADVRNIQEPFLVWRPFGIDIPDTKLYTHSMIYICRTLISYNMVMGFFIISLIVGNSFIYLDAWPMPLTAPFHALACFYFGEMLFNFRKEDSVQEHKTTVYYDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFB3</accession>
    <name>A0A8H7UFB3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFB3"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01089">
        <property type="entry name" value="PA2G4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000029">
        <property type="entry name" value="Proliferation-associated 2G4, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="2">
        <location>
            <begin position="26"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2183651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="407" mass="44462" checksum="3840E393F3644717" modified="2022-01-19" version="1">MELTLNYPQAKFEADNNLSDPNVISKYKIAADIANATLALVLQKLGAGVSTYALCRYGDDLIQAYPLPTLSIAQTSKMFKESDKGVAFPTCISVNNLVQYYTPLPSDAYTLKAGDVVKIELGAHIDGYIGTAAHTTVISVDPSQPVTGKAADAICAAYYAQEAVLRMMKPGTTSTDITKAIAETAAYFRCKPVQGTFSTQMKRFVLRANKDIDNRFDADITQHELEKNEFALEHNEVYALNVMICAGEGTVKDSEHKALIYQRNVNKSYNLKMKSSRQAYSEINAKHTVFPFAMSALANNQARLGLPELVNHGLVTPFFTTRGSMPSDIIAQFKLTVLITATGAIRTTIAQNLPYVHSQYTVPDQTNIAALLQSSEVKNPKAPKGLPEVDVVFGTVIPESQDVEMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFI6</accession>
    <name>A0A8H7UFI6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_008712</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NOP53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFI6"/>
    <dbReference type="OrthoDB" id="5072at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="232"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2181130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="413" mass="47908" checksum="30010816FC6EC648" modified="2022-01-19" version="1">MPVKQKNAQPSRKGKKAWRKNIDITDVEEHLEGVRSEERAGGKISERANDKLFTLDVKGDDRVKRQLAKDKPLYIDQILKSRSAIPAVGTRLFALPKESAKDNKGKESRINREKIEKLAKRKITQAPVKPAKKSKGTAYDVWADEEPTPVDLNPYLEPVRKRTVHAPSTLKVKPAAAEHQPAVEVAEAGASYNPTMEDHQVLLRKAHKVETDKISQRENVNKQLEYRKELLDLNEEEAVDSEVDEESDAHSDDDEETRKRKENKKKTRSERNRLKKAKETQQLELRRKQEKELHKEITKLEEIEKIVEESEMSSLTKAEKRKAKKEAQEQAGLPRLGKYFVQKAPIEVQLTDELSESLRSLKPEGNAFRDRFVSLQKRNIIEPRLPVNHKRRYRLKEYEKHSYKKFDRAQNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UG52</accession>
    <name>A0A8H7UG52_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_003252</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29535"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19518"/>
            <dbReference type="Rhea" id="RHEA-COMP:19519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132517"/>
            <dbReference type="ChEBI" id="CHEBI:132519"/>
            <dbReference type="EC" id="2.4.1.260"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29536"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UG52"/>
    <dbReference type="OrthoDB" id="19039at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052917">
        <property type="term" value="F:dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF1">
        <property type="entry name" value="DOL-P-MAN:MAN(7)GLCNAC(2)-PP-DOL ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034034055" description="Mannosyltransferase" evidence="13">
        <location>
            <begin position="17"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="14">
        <location>
            <begin position="520"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2177999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="608" mass="68174" checksum="F95DC6F4892E584B" modified="2022-01-19" version="1">MSKLIVFAIASIAAHAILCPYTKVEESFNLQATHDILHHRLDISKYDHLDFPGVVPRTFVGPLLLSLFTWPTIFIESHFAGQYAARLCLGGLICISLLRLSAATRRLLGPVTANIMVLLLCTQFHFIFWSSRTLPNILALPFVLEGLSHWLRSQATSDKNELNVCIRWMTFTAVVFRFEVGIFLGIILASEWLIYRNKALIPTNIVNGLVTAALALAVTVPIDSYFWQSYPTWPEGVVFYFNGVLNKSSEWGTLPVTAYATSFLPRLLLVSYPLALISFLVDHRARRILVPSLLYIAAFSMLPHKEWRFIIYTIPLFSIAAAITVNDVYVKSLKGSFLYRGLLLGIASLMLLSWLASSFMLYTSMHNYPGGGALEALHKLESPQANVHAHIDVLTAMTGASRFGERYPSWTYSKNENHTSQDDYILGGYTHLLTSEPDKFDSDIYDVVYVANGLKSVAIKPTSEYVNHLKAAPTWVKDPSKWHGLLPLTLKVGPAISILKLKEPTKTYVQALIRVHPKLVFSKTYCLPYISPYCRRAKMLLNEHCSGQYDVFEVDLQRNQMEFKRALFDISGRATFPNIFINGSSVGGSDDLASIVSENRVSEVLGCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGH5</accession>
    <name>A0A8H7UGH5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">INT43_000824</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGH5"/>
    <dbReference type="OrthoDB" id="63989at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10422">
        <property type="entry name" value="RNase_Ire1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13982">
        <property type="entry name" value="STKc_IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000077">
        <property type="entry name" value="Putative Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000572">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034440516" description="non-specific serine/threonine protein kinase" evidence="20">
        <location>
            <begin position="26"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="697"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="22">
        <location>
            <begin position="1006"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="403"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="473"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="589"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="893"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="589"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="600"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAG2184911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1140" mass="128885" checksum="D8B62BB3C6230419" modified="2022-01-19" version="1">MKQNIRLKVILLWAVTVALVKFALAASPGRQFRNSNNVRNKQIQQQLNNRFNTGHFSRTNFRESKLILVSTMDGSIVAMDKFDDYIYWTLKGGQNGELLKTASYFHSEEREDHNDYEDDEYADTVGDDEEDDDQSDMWRDLPPDIAPLVDVGEGEEATPEHNHHVYIVEPKDNGTIYLYENGKRLTRLPLSIKAMVDNSPVKLPDGTVYVGGKSTKLIAVNPRNGHILNKFNMDNAADVFDIASQHRLPSDTLFIGRVDYRLAIFNTQLKYRWNVSYSEYVPNAFDMDIDILKNEPSKLYVAPGPTGEITAIDLNQGSVLWTRTLPYPAVDVFDVYSRPDDTLAIVKQMVPQLPAVGQIGKLLSKRVTDNTAYVGSYNGHMFAMSNDNFPLVQLSEAYGNHGKHPLIEAGPSYDDDDEDDSNNSDSRQKQKGYARPSSDGHVYDPTPETVCTIDSPNFLSCMRGLHGVKRLDSPTSPNRLLDASDGRVSGSESGNPVPHIGAPDDRIAFGEDMLAKDGFWHTGIMAFWKTFLLVVLGFCYLRRKTFSDYFTRFGKPLVQEHILPQVERHVLPHVERYVESYRQRTVVDFDSDGNKNDKKAKVKANRNRKKGKDSPTPSIDSKASSTAIDVYPAKTDHLNRAVTFAKDTKPDENEDYTFVDIIDGSSQSAAPNAVTPISPPLPYVSSASTLHISSNFFFPYYKSGYGSHGTIVYKGTFDGRDVAVKRLLVDFYDIASQEVRLLQESDDHPNVIRYYFKEERERFLYIALELCYGSLYDFVEKTNSITDIHLLDTVNPATILLQIVSGLQHLHSLKIVHRDIKPQNILIAPGRTKPNQARNLANVRVMISDFGLCKKLDADQSSFHNTTASAAGTIGWRAPELLAGTAFSGSGSGHSNSSVHAHDKSSSSMSSTTDAMVGSVRVTRAIDIFSAGCLFYYVLSHGEHPFGDRFSREVNILKGSYNLDRLEDLGEDAIEAKDLIERMISSNPKDRPSAEQVMIHPYFWNNTQRLAFLQDASDRFEIEERHPPSPLLQTLEADAAQVIGHDWHKRIDRVIVNDLGKFRKYDGSTIRDLLRALRNKKHHYQDLSEPVRRAFGEPPDAYLHYFTSRFPYLLLHVYYVISEDEWLRDETMFKDYFQHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGQ1</accession>
    <name>A0A8H7UGQ1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGQ1"/>
    <dbReference type="OrthoDB" id="2289276at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034183993" evidence="2">
        <location>
            <begin position="20"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2181027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="335" mass="36162" checksum="39197FD3FF9241E8" modified="2022-01-19" version="1">MRVCLSALAAFLLATAVFAQEAGEAQATSSAVAVESSMAEVPAADADAAVPSASPSATADDAEAAAPSAAVSNSDFLMTEFDATPEVSTLELNQDFQTFNWVENSPVSAKSFVFELEAPAQLLLTDYKQAGDSFHVYDNGELIGATRKTEGTNAFAETPEEAVPIAQFSKAAFALAPGPHNITIEAISTFESGSGAVRLVPATEELMVQQQLYKHDDDEHDDKHDDDKHDDNKHGDKHWDHEEEEQKPDPVVALTRTQFVEVRTTSTLTTTITVPAPIELYPTTIVGTDAPVETMPSVVPGNPYPLPSPEREYGNKHGKWMKKKIENKMGKGDKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHE4</accession>
    <name>A0A8H7UHE4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Double-strand-break repair protein rad21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHE4"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21788">
        <property type="entry name" value="Rad21_Rec8_M_SpRad21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="5">
        <location>
            <begin position="507"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="386"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2179948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="62236" checksum="EA80819917DAEC80" modified="2022-01-19" version="1">MLYSEAIITKKGPLARVWLAAHWERKISKNQFLQTNLEKTVDAITTEQQEALTLRLSGQLLLGVVRIYSRKTRYLLEDCNDALVKLKTAFKKGDVDMPDSHRHVANLNAITLADNLTEFDILLPEAPLNLNRNPNEPIMDLSLSMSNISRRQDITISQNGTDAQLLGLGFNDDILDDIETGRDMFHQGAGSDLQLADLGLDDMNEIEMAREAGIDRSLTMDDIGAPLERMNIKDNNDDNGFDFDLGSEPDILPTDDAQLDRPIDDNSSFDLPDMSMMTENNSALVPDTQAIGDDLLFDVETPAAQANTPQVHRRRLIIDKVTELPHDKIRDQINDTSDIVSDATFLPATVEMLQVRNIEKQGVRLFFNLDAPNFLAPELQSLFTRSRKRSPSVHSIADEEEDHHRKQQRIEPATTAQAAAVRRNVEEEEDSFELSVLSDEEQPATKPLEVTEKRAGIMPYESNLSQATTSTQQGPSGFSKHTTETMTMLEAEFEKKKQVGEDPKVTYQQLTGQDTKRADAVKLFFEVLVLSTKDMIKVKQNKPYGDITISQVVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHR2</accession>
    <name>A0A8H7UHR2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHR2"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="165"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2186306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="316" mass="35083" checksum="BA74DE7C47BA5A6E" modified="2022-01-19" version="1">MEQIPVIDFGMFESDPIAVASQIRAACETIGFLYLTNVGIPQTEIDGAFRLSASFFDQPLDSKNKFARDDNNKGYIGPRGEMLDPSTQKMGENKECFNFGKLINGKPVQPLPAPLDANEAFLAKFSDCHNLCGRILQAFAVALEIKEKDGGVHYFEDRHKYDVACGSVLRFLKYPKGDNNNGIDIVRCGSHSDYGSITLLFQNGIPGLEVQASRTHWISAPVIHGAVLVNIGDQMEYWTGGRFKSTKHRVVHLPEYADKDRLSIAYFCQANDEVLLDAIPSGLQAGSQYYHDHPVKSAGQYLQERLDASYNFFTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UI42</accession>
    <name>A0A8H7UI42_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Seipin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_007473</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UI42"/>
    <dbReference type="OrthoDB" id="3990054at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="330"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2182542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="41059" checksum="0A799DFD175DDA4A" modified="2022-01-19" version="1">MRRAEQLILIPQQSDQFQVVPDHVGHDTFSTTSTQDMMQRIDPDAPLPEASNEPTPLLLIIVSKILQLLRPVFAIIFSPRVQRTVIRTAFLTIALSWIMGVAISAYIAFYMTHVPKTAHIEPVYLQYNKGAEPMALVDLTNKGSYLKPLRHEQQYKVDVLLHVPNSEVNIEIGNFMVRVDLKTADDKTVSYSSRPSILRYQSALHRTLAIFAKALPLLLGIAKETQTIIIPMMEHFVEDGTHPVTKAIVSVSDHRLQIYHMHLHMTADFHGLRYGIEIYYMYNHRIITAMVFITLFICIELSFATVAWRLFGYTLWTRITRWADNVAKDNADSQEETTAAITGGDTTSEKSDDQTHEDFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIE5</accession>
    <name>A0A8H7UIE5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_004008</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIE5"/>
    <dbReference type="OrthoDB" id="338531at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="6">
        <location>
            <begin position="11"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2180219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="772" mass="86888" checksum="4651C95262AB6D63" modified="2022-01-19" version="1">MSQPEDAIERTPEYNRFMSELRDFHKNHGTYLQAEPVLGGKKLDLLKIWNRVQEAGGFEQVTQSRTWKQVGDPFNFPVTCTNSAYVLKAVYIKYMLGYEEEKVWGRTWVPPSDALEVNQKPGQSTASPGPPKLPVAYKPTNVVRKTATGDFLRIIAFAPQAVSKPYTPQPQIMPHRPPPNVMQTRPMMSADHLMYDENFRTRITLALKSRLPNEVDWAFNNLVRLSFVSEDFNLAYMPQLLDNLVSFAEPFFQKYVFPLVGSDSNTGTIAMERAPILNGATAMEGVEQENANATQEQNQEYSNPSDPALSNDITIEADDHLFNSKEYQEELERVLQVLHILRNASFLESNSRAISQNAKLPSMLIKGLASSCRAQFIELSQHCLDILENIAPTIILKSRLDPYLVALSRLVFTNDKALILGATKALARVAVTEVNEKVFSIPDIDVLKRMIEFLFVNDEELLAATLEYLYQHTSVHSDLATELLNLYPGNIIGLLTGFLYYHSSIVPNGTLANVDMITITEAPAPPPTKGPGIPDLTNYAQLDEPYRCLGWVKDRLQSAGPDGTLVLGDVYRTYQARFGSNKPLGMREFYTVLKIALPQGEQAEDHELNAVVLKNIMWNPNSSGLDSPCLWQDCKALFATDKELHRHILETHVPKSDEAAGYTCKWMSCTRFSTPINNRHTILSHLRIHFADKPQNISKQKRVQVTSNNAIPVDDTEISGVPLTAALLLRNLVKDKRHHAYFLPFEQDIIMTGIQRPKLERYTVAVTTALQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJN0</accession>
    <name>A0A8H7UJN0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WIBG Mago-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJN0"/>
    <dbReference type="OrthoDB" id="21625at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903259">
        <property type="term" value="P:exon-exon junction complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039333">
        <property type="entry name" value="PYM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015362">
        <property type="entry name" value="WIBG_mago-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036348">
        <property type="entry name" value="WIBG_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959:SF0">
        <property type="entry name" value="PARTNER OF Y14 AND MAGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959">
        <property type="entry name" value="PYM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09282">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01273">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101931">
        <property type="entry name" value="Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WIBG Mago-binding" evidence="2">
        <location>
            <begin position="13"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2182243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="170" mass="18865" checksum="6ADF0FE4DF66039B" modified="2022-01-19" version="1">MSSNASGIVGSGEDRYIPGSRRPDGTYRKERKVRPGFTPAEDVVRYTNARMEASKPSTYPPGYNPKAKAESATNAKKSQKKKPQQVEPPKSSTETTTVRSAEKNDHPLTEDSSTVGKSEADKKIKQLQKKLRQIDDLKKKQGSGEKMNEDQLEKLAKAKSIEEELSKLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UK03</accession>
    <name>A0A8H7UK03_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_000476</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UK03"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF53">
        <property type="entry name" value="CHORION TRANSCRIPTION FACTOR CF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2184567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="391" mass="43338" checksum="64A3C98E6079EF2A" modified="2022-01-19" version="1">MGTQILPSQVEESQPKLNPTIVSVSAGPGHSLVVPSMEHEAYPSDDDEDFYHQLPNNPSPGINIVPPNRQVQTVYSDYYQPNYHMYNDGVFGNQNISYTCFEDELNGFSLPENSLGESYGSYSDASLVFSPPRPDSEMEFGSANNSLRTHALQDLMNQGTSAADLQQLTRSTSDFIVSDVFSMDEVSAQNGHLFSPQSYEYHPLMHGLCSSSPITPAAPLETPVASQDSMASDSPYEEPCYLSPMSTDMSYSVASSCNSESIFHSHMRATSTSRSPTVSDHPLSRTSSNRIRKAPSDLILVSGPSGSRHYHCKFCPHTCKRTTNMREHQKKHDPNRPRPFVCMICSKGFARKSDLKRHVRLHLKEDPETAEFALTYISLLSNPPLPHSSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKH7</accession>
    <name>A0A8H7UKH7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKH7"/>
    <dbReference type="OrthoDB" id="2396885at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029005">
        <property type="entry name" value="LIM-bd/SEUSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10378">
        <property type="entry name" value="LIM DOMAIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01803">
        <property type="entry name" value="LIM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2185092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="537" mass="58711" checksum="8B2ABD0D17447B07" modified="2022-01-19" version="1">MSTTTQFATVPPTVQQQQLSRQRHLMLLQQQQRQLSRLGTGTQLTPQQQQQMYAQSNGAQQQPIPGVQTTATNASNPIYNPIPNAAFGNSSSPVVSAASIPPSMASNPALQRMPQTTAMPGQPLAKRMVTMNTGHIPGQITAQQAGPASAGSAILRLLQYSDSLGPGAETKELSYWHRVISDHFSEEGTFRHDMTNHQSDEKKVFEIPNSLLARYYLTYFQSGVVQMNWTLETPMEYMSPTGAWIVDTPQASLTQFFDNGSHIVLNGRLRVQLSPSPVTGLLKIDLLDYSSHGYTEYIPRNSILGLSKHESLKRDNKNLSSKLDGLIRDLLPECLVNDFGVCPRVMRCLEIAEVVSSFEDLIHYSRMSNTGPLESLKEVSQNIQKRLAQMGNAAAMGSFIQDDMLPGSPVIKREHQASIDAGKSPMLQHMDGLQHHMDPNSMKGAGMMTPQQTPKTNSPSQQSPSMAKRKGSPGDHDINGYAANDMNTPMPSQMASSMMASPISVNSPVAKKRAANTSPRARKKNSKAARANADTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCS2</accession>
    <name>A0A8H7PCS2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pru domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008236</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCS2"/>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13314">
        <property type="entry name" value="PH_Rpn13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.70:FF:000001">
        <property type="entry name" value="Proteasomal ubiquitin receptor ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032368">
        <property type="entry name" value="RPN13_DEUBAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16550">
        <property type="entry name" value="RPN13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="7">
        <location>
            <begin position="8"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2171510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="333" mass="37109" checksum="2068A41A11066352" modified="2022-01-19" version="1">MSLFPTPQRPKHLVEFNAGKCYRDGNMLKPDVRKGVIYMDQTDDQLMHFFWKDRKANIVEDDLIIFPEEAEMVRVPECETGRVYLLKFKSSSQKLFFWMQNKDDDKDAEHVERVNKLISDPSSAIAEQQSRSGSGSGDEEDSAADVLSLLGSSGQELGLTQEQIYQFLQSAGGVGSVTLSSDGDDHATVTITARENSDEPVLDSELLRALKEVVNEKSVSDDTPITSDLGEVLSSDEIGAILNDQEISEAVFPTIPYVKDRSPEQVNDLVQEDTFRTSLRKLEAAYRAEELEPFAEALKVEPSGGLVDFLKALQKQAKSREDDSEISEAMDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCV1</accession>
    <name>A0A8H7PCV1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCV1"/>
    <dbReference type="OrthoDB" id="2341392at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="1">
        <location>
            <begin position="20"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="371" mass="41410" checksum="0E0E8DD87309533A" modified="2022-01-19" version="1">MNHIRIIEFELQGNEIDLIDRTDVSRAEIKGNLHFQVQKPTKLASIIIKLQGECLMVLNKPSPVERTSPAGTSSPSAKCHLVNSSNDILDEQKEFTTGTHVVPFSFNLRNDLPSSQEYNFADGSISITYKLSAVMQPPTNTLTKLVRSVSNSRAVAESFRTVNIKRFTAPSTTSLFPIKMAGYQGTTDQDVDYVFKIPEMVIASQQRLRIKGSLESNDEKCVIESVTTEIVERKTISLVSRDPLRPSTYAMHLGYKPLIETRVLGDCTYRTGPQLGQAIKLDYEVGFRSEDTIPPFTSPMLDIDHYLNVRIAFASYHSDALLKLPIQIATIQEWGGSPLSPQFSEQSPTSYKRGPWSPNYDRVSISATVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD86</accession>
    <name>A0A8H7PD86_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008132</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD86"/>
    <dbReference type="OrthoDB" id="427213at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="546"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2171752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="684" mass="75622" checksum="BA3358BFA32D6531" modified="2022-01-19" version="1">MSVTPSNIKAPTTGSNSPTLDLDDSDDESLVEVQNTEASRLLGEELYPRYVTASPLPAIRPREDVPKDTWTKLRTRSKYYFPVLQWLPSYSFNLFTGDLLAGLTLSCLMIPQALSYATALCKLEAVHGLYAIAFPAITYALFGMSRQLSMGPEASLSMLVGSAIAQQQHMEVDDDPLKSAVAISCLLTLFVGIFTFCLGIFRLGFLDSLMSRALLRGFITAVAIVVMVQQSITLLGLVKLSEEWGITEASSTIDRLVFLVENITHTHALTAFVSLVACTCLFGARVIKAKCSSIRWLQLVPEVLIVVVTSIILTGVCRWDEEGLQVLGEIKGGGIPLPSLPDVPHRKHFREIALTAALISMIGFVESIVISKTYSSKHNYTVSANRELVAMGAANIMGGLFQGIPAFGSVARSKINDRAGARTQMAGFITGVIALLAILFLLPYLYYLPKAVLSSVIFIAVLYIIFEAPEDIHFMFKIGAWRDFTLFCLTFLATVVISLEFGTLLAVGLSLLLTIKETSYPRITIMGRVKGTHNKFRPIKDGPDFIEHVEDVLIVRIEEPLFFANTGNTGQLKDRLRRLEVFGDMSIHPSENPRLRDTSFIIFDVSNMPQIDASAVQILFEIVESYHARRVEVYFVRLRDNALDLFLRSGLLDIVGRDHTFKRVSDAISAIEKMTSSRPQVTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEX0</accession>
    <name>A0A8H7PEX0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GPN-loop GTPase</fullName>
            <ecNumber evidence="7">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_000026</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="7"/>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEX0"/>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000579">
        <property type="entry name" value="GPN-loop GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="277"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="315"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2172679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="381" mass="43045" checksum="16A2A66BA4E06648" modified="2022-01-19" version="1">MSTENTSAAPEGKQPTTILCIGMAGSGKTTLMQRLNAHLHSEKRPPYILNLDPAVGNLPFTANIDIRDTVNYKEVMKQYNLGPNGGILTSLNLFTTKFDQVLGFVEKRASSVDHILVDTPGQIEIFTWSASGAIITDTLAATYPTVVAYIIDTPRTTAPATFMSNMLYACSILYKTKLPFILVFNKTDVVSHQFAVDWMTDFESFQQALQQDTTYMSSLMNSMSLVLDEFYSHLKVVGVSAVTGEGMDEFFTAVDEATEEYEKEYKPEIERLIREKQEKEEQHRQQQLSKLMNDMKVSKGSEVPLGQQPKRMEDETWEEEDEEHQDEDEDEEGEEEEEDGSDEEEENTLLSASRFPPSANQRQTDAKFKAWLTQANQSSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PF76</accession>
    <name>A0A8H7PF76_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Symplekin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_000192</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PF76"/>
    <dbReference type="OrthoDB" id="331600at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021850">
        <property type="entry name" value="Symplekin/Pta1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032460">
        <property type="entry name" value="Symplekin/Pta1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022075">
        <property type="entry name" value="Symplekin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245:SF20">
        <property type="entry name" value="SYMPLEKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245">
        <property type="entry name" value="SYMPLEKIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11935">
        <property type="entry name" value="SYMPK_PTA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12295">
        <property type="entry name" value="Symplekin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Symplekin/Pta1 N-terminal" evidence="5">
        <location>
            <begin position="67"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Symplekin C-terminal" evidence="6">
        <location>
            <begin position="892"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="278"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="536"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="759"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="279"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="762"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2172842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1115" mass="125666" checksum="9A03C1148704C556" modified="2022-01-19" version="1">MSLHLHHEERHLRSLQDFESEVASDPTNAQVFATNDFLDVLSSLIKDSYDQTAETPDYDENYESEIELLKSAVRAFATVVPYVFSSVCQNEAETRLWQNVVVVKSTIMDSLVHHQNQGVRFAAIKCIQVFILMQSRKEVNSSSSSNDINISLIRTGHRLLNADELIEEANSMIKKMESLLKDPTMTGPTITAILNSIIPLMKRRPQFIPKLIPILVNWNRPPPSQLSSVQMRNVDKSVKLVFITLIRSEQLSSQRTELINAFGAAGGDAAAMFQSRSQKLKEKEMRERERRDSSEERRSGKRPVDDRSATSNEKRQRMGQESGSAVQLAGFDFNSLPLPMVAEFCLAILQNTSIETITERLPLVHQALSNGATRSATPVKSEPSHMVTPPQIVSARSPDMRGVKIEGREVSTPNNQGQTPEPDGIKSESSDYKTITTVGRNPLPSTQERVSQSFKMQPYALAAPAEFAKRQKMEMLKLAVQRILEAEKLSQQALPIIDPNEEEESSGQRQAAITFNSPLKTTWTLLVSKLIANSTRAGKSTPTNDSDGQLDSKMDVDDIDEDDPSSLEVDELRDMLLEFIIENLPQRQELAVQWLYEELRTDLKNASNTDYQPKYTHWLLKLITSAMPILQNNDRSLSKLLLDAPELNAEVVELLKADMDRRPDRYKATVLVLHDLALFRPPVRSQCLDVLLNCCTMQDKNKRAFAILDVRKWVPDHALSPVVEEFSIRTVRRLLEEPPEKVEPVVEPISEQDDTAAMEVSGDQQNGAQHDGTEQNGQVAQSTAAEWDEETVIPHLELYFALCSKKPELLNSLFDVYINTTPQVQRIIRQHITTLIRRIGMQSPKLLQIIGNFAPGGETLIIRFLVVLCDTVRPSPELVEVVKRVYQERNLDAKFLIPVISGFTKADIKQHMPKIVSLLNGTEAQRKIVRAVFSRIISDSGNVSAHMTPVELLVILHNTDQNVSPKQGIEAINICFSMTEEFTTEVISTVLQHLIDQPKIPLLYMVTLIRSVSEHPELVNLVLSLLQKLISKRIWTSPKLWEARSKINNCLTHFLKKTHPQSIKVVANLPKSQLMDVLTKVPSISNGLREFAERNGLMRVLVTMNEMGLIEEEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFB7</accession>
    <name>A0A8H7PFB7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SMAD/FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_000213</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFB7"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE DMA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17123">
        <property type="entry name" value="zf-RING_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="83"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="216"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="386"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2172863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="47426" checksum="14174FD74CAA0F86" modified="2022-01-19" version="1">MLQGPAFTSASILSRSFYLTGHRPTTSSTMASDLSSETSSAIANNSGGQQIKTRVRIVPSLENNARCVVFNVIDRELSPGTVLRIGRFTDRGNDENRITFKSKVVSRSHCELWVDMHGKLHIKDTKSSSGTFVNHVRLSAAGQTSTSHLLSDSDTVQLGVDYQGGVDEIFRAVRMKIEINRPIQSSAYSLATFQQLKTLDSTQQLGPLDSSQLDECCICLYAIAPRQALFLAPCSHHFHYKCIRPLLASHPGFQCPLCRSYADLDAPVEVDQPQVVPENNPSHMSRDVPVDPIPVPITRTPVESADGVAGATFVSDGEDEEVRPRDTTVEPDVDLLEEEEHDSIGELATSPTHTTLPIDQRRHSTSGLVDKLKMVIFDKRRLSVSGGKRRRSNYDEDERDSSNLEQQPIVGSPESSSSTTARMSASIPFFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PG13</accession>
    <name>A0A8H7PG13_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_004597</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PG13"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000594">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="411"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="597"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="69"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="164"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2173223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1042" mass="119819" checksum="E34CC18CBB19D069" modified="2022-01-19" version="1">MADLRSWVSDHAITLFGMSEKTLVDFVIATAQSAKSPESLFASLQAADIPETDAARRFAYDLYARVPRKAKSGSAEKAQRKREEAEMSKIRKANESYSLLLDDEEDEEEREAKRLKKLKKKEKKLRKKEEEDKWADDEDNKPAVDLDRRHQRRDEDTQMDDEERERLEDMKERDEYAQRLKEKDKDKTKSMVEDRSSKGDTEATRRRNLADDRESRAAALPDIRDRSRQEYLKLREQQRLELLRQEIQDEAFLFGDQKLSKKEIQEHEYKKEVLRLAEARMKIDTKEDGYVMPEDYITEKGKIDRKKKETALYKRYQEEEKFVSEQDQWEQEQIKKSAAKADQGQPDDEYDYVFDEDQKIDFVMAAKINSKDKDGQDVELMERIDEAERKAKSIAEVRKSLPIYQYRDDLLQAINDYQVLVIVGETGSGKTTQLPQYLYEAGYTKGGKKIGCTQPRRVAAMSVAARVAEEMGVKLGYEVGYSIRFEDCTSDKTVVKYMTDGMLLREFMTEPDLAAYSCMIIDEAHERTLSTDVLFGLIKDIARFRPDLKLLISSATMNAQKFAEYFDEAPIFNIPGRPYPVEIFYTKAPEANYLRAAITQVLTIHVTQARGDILVFLTGQDEIEAAQEGLTQARKALGSKIGELIICPIYANLPSEMQGKIFEPTPEGARKVILATNIAETSITVDGVAYVIDPGFIKQKAYNPKTGMESLVVTPASRASATQRAGRAGRTGPGKCFRLFTQWAFYNEMEENTTPEIQRINLGNVVLLLKSLGINNLFQFDFLDPPPSETMIRSLEQLYALGGLNARGELTKLGRRMAELPMDPMLSKTILASEKYECSEEVVSICAMLSEQSSLLYRPKEKKVQADTAHKNLIRPGGDHLTLLNIWDQWVETEYSMQWCFENFLQHRTLGRVRDVRDQLVGLMDRVELKLTSNPNPADTVPIRKAITAGYFYNGARLNKSGDSYRTIKQNQTVHIHPSSSLLEKKPRWLIYYELVLTSKEYMRQVLEIQPEWLTEVAPHYYKEADLDNLDDKKKMPKQPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PG27</accession>
    <name>A0A8H7PG27_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-phosphogluconolactonase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PG27"/>
    <dbReference type="OrthoDB" id="9972196at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000306">
        <property type="entry name" value="3-carboxymuconate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF1">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="38962" checksum="7AA70E925716E8FE" modified="2022-01-19" version="1">MSSTSQQTYISSYTDDGGEGIYLYSFKDGQLSLESLAAAATNPSFMAFHPNRTYLYCVNETSDYDQDNSGSVSAYERDATTGALKLLNTVTSKGADPCYITIDSAGSHVLVANYNGGSVATFPVQADGSLGEAKAFIKHSGESKVNAQRQEAPHAHSINLCPSEQYAIALDLGDDKAVVYKYDRAQGTLETTSEFKFQPGDGPRHLVFTPFHHSWCYAVAELSNEIVFLDINENDGTLQEIQRLPALPEDFQGTNLASEINITPSGKFLYASMRGHDSFSIFAINENNGKLTKVGQQSTGGAHPRHFNIDPSGEYVIVGNKDGHNVVVFKIDQSTGFLTKISEVQQRQPVCIKFYTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PH28</accession>
    <name>A0A8H7PH28_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PH28"/>
    <dbReference type="OrthoDB" id="2446850at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="185" mass="20747" checksum="3D5B1284B3D217EB" modified="2022-01-19" version="1">MSYSQINGYGGYSGYNSEYNANGRGVNALYNGAYGYPNNFEDYTAPQRDFKGAWTAFFALWLLWGLFWFLRHAFGDGHSVDADAEANTKSRWQVGTPHSRLSRGSDVLRDLVVLLLAALAINTFAGGITHAVMILSWIFFGFAVFWAVFEAAVEHHIARFIFGFIFYGIAIAIAALGYRYGWQSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PI32</accession>
    <name>A0A8H7PI32_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_005076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PI32"/>
    <dbReference type="OrthoDB" id="10062838at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2173656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="44561" checksum="DD7E879AF6CB3F17" modified="2022-01-19" version="1">MSYDSISPPAQDPLDTIPHSSSSKSASRSRSMVALAMLCMCIASFVVQTELAQFVQQTSDFRKPYFILYIGHSSYMLILPIQFVTEYFKRWHSTRSASSFRERCKQVFQEAFADFKGDLAALVRHVRPDDYQTTSLEEASEDQLVKSLHMSPRQLAYLVRITLALAIMITVPAYLWYITVNLISTASLTAVYNTACFWAYLFSILLLGEHIVTRKVLAIVLCILGVLFMAFWSSEDTENRHNPFGIPMAVMGAVAYGYYEVFYKQYASPPKASVLFANVVTGLMGITSLFILWIPIPILHFSGYEVFELPSWTTLGYIFGIAVTGVMYNAGFMCVIALVNPVFAAVGIMLTIPAVAVADVLVTGVMVPMSTIVGSVCILLGFAALSYELSKDEDDSSFEAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PI64</accession>
    <name>A0A8H7PI64_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_004321</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PI64"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000011">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000237">
        <property type="entry name" value="replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="55"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2174298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="346" mass="38194" checksum="40C41E3395CD1F86" modified="2022-01-19" version="1">MSTFFQNTKSAAANHGKLPPEAQPWVEKYRPKSMNEIASQEQAVQVLKKALTSQNLPHLLFYGPPGTGKTSTILALSRELFGPELMKSRVLELNASDERGIQIVREKVKNFARTTVTATADGYPCPPFKIVILDEADSMTTDAQSALRRTMETYSKTTRFCLVCNYVSRIIEPLTSRCAKFRFKPLPIKNVEERIQLVCSEEGVQIEPEATTTLIQASNGDLRKAIMFLQSGAKLHAGQKILTSSINEMAGIIPPDAISSLTAAWYSTEYNEISAVVNDIMNAGYSAEQIVSQMHDHLVTDPELSAYKKSKISLILGEADLCLINGADEHLQILNIMLQAADIVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PID1</accession>
    <name>A0A8H7PID1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-lactate dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_004318</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PID1"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903189">
        <property type="term" value="P:glyoxal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010646">
        <property type="term" value="P:regulation of cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023051">
        <property type="term" value="P:regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03135">
        <property type="entry name" value="GATase1_DJ-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000022">
        <property type="entry name" value="protein deglycase DJ-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006287">
        <property type="entry name" value="DJ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01383">
        <property type="entry name" value="not_thiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF12">
        <property type="entry name" value="PARKINSON DISEASE PROTEIN 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="5">
        <location>
            <begin position="4"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2174295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="205" mass="22406" checksum="397421671216929D" modified="2022-01-19" version="1">MTTKKALVLLADGSEEMEFVIPVDIFRRAEIRVTTAGVGLKNGTYAECSRGVKILPDVEVEHVGVSWNEEDYDAIVIPGGAGGAKILSENAQVTRLVSSFYEKQKVVAFICAGTLVAKAANIPDGHKVTSHPSVKQELEESKYHEQNDIMDSYRYSEDRVVVDQNIITSRGPGTAFLFALTIVEKLVGKEVVEKISPPMLLPQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIG7</accession>
    <name>A0A8H7PIG7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_004413</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the BBP/SF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIG7"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02395">
        <property type="entry name" value="KH-I_BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000024">
        <property type="entry name" value="Branchpoint-bridging protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032570">
        <property type="entry name" value="SF1-HH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047086">
        <property type="entry name" value="SF1-HH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16275">
        <property type="entry name" value="SF1-HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9 13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="15">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="15">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="373"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="521"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2174390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="559" mass="60753" checksum="63A45CB453E8D0B3" modified="2022-01-19" version="1">MWKPTGTNDIPLGAKRRLGDSPDGSLSPKANGTGTSVSPTTERGRDPSPKVTTGSTNSEERQRKRKSRWGATDTKINIPGLPTAISSTMTKEQREQYSVHLRIEEINRKLRTGDVVPNERDRSPSPEPIYNADGKRVNTRDARYRKKYEDERQRIIEDAIKKYPDFRPPADYRKVQKTTEKVWIPAKEFPEINFIGLLIGPRGNTLKKMESESGAKISIRGKGSVKEGKSRTDAAANANQEEDLHCLVTADSEDKIKIAVKLIEKVIETSASVPEGQNELKRSQLRELAALNGTLRDDENQTCTNCGGVGHRRYECPEQQNVTNNLTCRICGGQGHMARDCLQRNNPEFMQQAQEREQQLDSEYANLMAELGEKVTDGDATAKTERPPWADRAAATVAASGGQAPWQRGGSTGGASGGGNPWDKPNASSNGDVPWARNNSYGGQQGAPHYGGQQGYGGSHQAAYGAQQGGYYGSNGYGGYGGYGGYQEYDQGYNQGYDHGYDQSQPPPPPPSGDAPWSQQVPPPPSSQYGAPPPPPPPSEPVPPPPPSETPPPPPPPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIS2</accession>
    <name>A0A8H7PIS2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_005781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIS2"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2174723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="218" mass="24891" checksum="A11DF73E28BC5914" modified="2022-01-19" version="1" fragment="single">MTTSLTSRVLKLEQEFFPTLSPAQIKALTYNGSLETRDSHLYGEFAFLASGLKPCLLICFPDPKLNRFYTEQVVNKAIENSQNLQCYSIQRDIISDEMNLRGTSIVVNRDTTHASQIVKLLEDETFNSISEDKLAVFLDYPGSLPSSAEELDSMLEVAYLDATRQVNWLIRSSEDPIIVTTFAAQESEVDKVKEHFQRYRAKMLEMNIDLQILIRKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJ29</accession>
    <name>A0A8H7PJ29_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_005974</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJ29"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Beta-galactosidase" evidence="9">
        <location>
            <begin position="58"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2174912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="660" mass="72751" checksum="769D06F9DF5BA804" modified="2022-01-19" version="1">MTVFMQGDYMTYGGTNWGNLRFPDDYTSYDYGAPIDESRQIGSKMYEKKLLNYFLDVATEMAGTNLTTCSASASGIKCDRLYNKETESSFHILRNSNISGFDNFDFMLELADGTSVPVEDNIAIHGRDSKILPANLGFLNQHIIYSTSEILTWGSIDGVDYLVLHGLSGESAEIALSLKGSQKPSIRVGSGSIKTTVSSSSIRLNFKHNGLQQVMISGSHPLVVLMADLEYAYKFWKVDTKNGPAFLFGSYLLRGVNEGEHDVLSLRADTSESETVELFASSKFKSVEWNGEKLHISSTPRGSRSGKVHGPQKAHVPKLQTWTFARESPETSATFDDRQWKVANKQSTNNPLPQPAGQPVLYASDYGYHIGHIWYRGTFQASGDETSLNITAQGGDNSVYSTWLNGNYLGSSNHSAGGKPQLFNITSKQLSKGNNVISVLVDGMGSDEEGGGASEYYKNYRGLREAHVLDNKGSEAATISWKIQGNLGGEDIVDTDRGTFNVGGKYGERHGWHLPGFSLSTRKFQSHVKLPHNFGDAGIAWYFTDFKLDFPAKSDNPVVVAFDMPKDQSYRAEFYINGWNYGKVIPNLGPQDEFPVPPGILNTNGENRLAIAVHGMLDKSNVFSDVQLKILNSYTFSGEQWTQTKAPGFDKKIYGASTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJR8</accession>
    <name>A0A8H7PJR8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphatidylserine synthase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_005861</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJR8"/>
    <dbReference type="OrthoDB" id="10265393at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106245">
        <property type="term" value="F:L-serine-phosphatidylethanolamine phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004277">
        <property type="entry name" value="PSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF7">
        <property type="entry name" value="PHOSPHATIDYLSERINE SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03034">
        <property type="entry name" value="PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2174799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="50594" checksum="CF55AA3E50A16316" modified="2022-01-19" version="1">MTTPQWLGRSYTETSSMYSETPMSESETPILERDSLQMAQDQPDPAVEAVLRPRTLSALMILLSCLLYVAVTPDIDSTETNVKLGITAAVACFVFIGMLQFRDGPFVRPHVVFWRAVLSLSVLYQMALVFFLFLNKHQARQMLKFVYPELGVALPDRSYAEGCDLTLDNFKNQIDIFVLAHILGWYAKALILRDYWFCWILSIMFEVMEYSLQHQLANFAECWWDHWILDVLICNWAGIYLGMKTCQYFEVKHYSWAGHFRHIKGIKGKAKRAVQQFTPHDWTRFEWKTTNSFKRWIAVLALLVVFLQCEINCFYLKYLVWVPPEHPLLTYRLILMFFFALPATREAYQYLVDRNTKRFGPHAWTMLANIFTETLICIKYGRGEFPEPAPLPVVLFWSFFTTGLVSYTVWRFWWLPKARKNKATTEQRKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PK68</accession>
    <name>A0A8H7PK68_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_001150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PK68"/>
    <dbReference type="OrthoDB" id="2432613at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034620608" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="30"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2175503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="241" mass="23915" checksum="2C16B0D025E122E9" modified="2022-01-19" version="1" fragment="single">MVSFTVISSVIATVFAAVASASTPIAPSEPAPGTVWTIGQPGTIQWNSAPCNHVLNSVFDWLDFMTGDNINQITLGNVATGLDGTTATTYSWTCPNVDIHSAIYFFMFTSTTNSSDMAWTTRFAITDSTGALTTPPNATQTDGEKIPWGVGHLLSGAASASAPAASGSLSAASAPATNSVLAPTANTNSLSAAPPAASGSAAPSAASPAAASPSVSQKSSASKVLTTAGLGLGAVAAVMMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKQ4</accession>
    <name>A0A8H7PKQ4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="8">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_001310</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="8"/>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKQ4"/>
    <dbReference type="OrthoDB" id="17199at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000003">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF0">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="10">
        <location>
            <begin position="106"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="58"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2175663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="216" mass="24024" checksum="9EB0D6799F63492A" modified="2022-01-19" version="1" fragment="single">ETDTTGKPEAKDASRAKHGPESGMSIYIDPVTGQKIPMKDGKPCRTCIDMKTWKRLGKVASAKDAAESPKTTEDGKKDATKSVAESNATAKSVSPADDTEWRRKNCPPDVEALGSSTWTLLHTMAAYYPERPAPSQMDSMKMFFEGFAQHYPCWFCKGDFQKSVAANPIQVGSRKKLSQWLCDRHNEVNEKLGKPKFDCTKVFERWLEGPPNGKCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKR5</accession>
    <name>A0A8H7PKR5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMA16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKR5"/>
    <dbReference type="OrthoDB" id="270284at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.170">
        <property type="entry name" value="Translation machinery-associated protein 16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021346">
        <property type="entry name" value="Tma16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038356">
        <property type="entry name" value="Tma16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349:SF2">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11176">
        <property type="entry name" value="Tma16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="186" mass="21265" checksum="CB9B8FC89C04AAE5" modified="2022-01-19" version="1">MHPSSRKAFQLTRVVMRNDRLEQRARSKETVGNPKIDRYLWFKFALDDTLPCATTEELHSLIQMYLCRHDEELENLQALRKGNRPKTGRQDILEALIKKEKDEYEKGFGKTANYLDIMTHIAAFADTTISSCLELPDLQNPKNVKILRSWDGDKNSMARIKTKTVVNPDANAPSKSVNSNAMDVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKU8</accession>
    <name>A0A8H7PKU8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Choline kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKU8"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF93">
        <property type="entry name" value="RE24176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2175585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="47866" checksum="D0111B4DEBEACEE5" modified="2022-01-19" version="1" fragment="single">MPVPFKMLDGSDPIPSQPASGSSSYINDSVFDQAPQFAKTHSNMTSYNELAPSSHSVPSADDEIDLLSVKGEQLMKTAITVIQKLLPEWNDVEHAELDRVSGAMTNAVFFVTAQNPYRRVLLRVYGIGCDQLVDREQELVWLGILSRLGIGALLLGTFANGRVEQYLDCYTLTRDDIRVPKTSCQIARGLYELHAIVHSYPNEVNILPELWRNIFNWIPIVQSILPNLEKRSEHHRSTIKCFDLPQAFADMPVFKKYLDNLHSPIVFAHNDTQYGNIMRLRDGTERLVVVDFEYSGYNPRGFDIANHFCEWTADYHSNEPAKMHENCYPSLAEQTRFIDAYLDERDVVQGITSSKSQRQLEVDQLLREVAGYRLASHFFWSLWGLIQANQSEIDYDFFQYATERMTSFQTGWAAWKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PL44</accession>
    <name>A0A8H7PL44_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lon protease homolog, mitochondrial</fullName>
            <ecNumber evidence="11">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PIM1</name>
        <name evidence="17" type="ORF">INT43_001342</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer or homoheptamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12 13">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="11"/>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PL44"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070407">
        <property type="term" value="P:oxidation-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000001">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1480:FF:000003">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.40:FF:000010">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000015">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03120">
        <property type="entry name" value="lonm_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027503">
        <property type="entry name" value="Lonm_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11 12" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="16">
        <location>
            <begin position="169"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="15">
        <location>
            <begin position="934"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="100"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="275"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="868"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="324"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="885"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="1026"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="1069"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="639"/>
            <end position="646"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2175695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1148" mass="124247" checksum="E2E7CF6E46C5EBE6" modified="2022-01-19" version="1">MSSTFLLHVAKTIPRSSIKQSLLSQLTGASTSARSLSTSTPATHASNLTIWGGDAIARSIRDSPSRSVFVALQPVRPFSSTSAAAFNGSKAGKAEVLRLQDNKGGDGSDQPPSSGSGEGGANGAANGGGDGKNGGDGDGGAPIHNIQKALNVIDNQLQKPSVPEVYPQVLALPITRRPLFPGFYKAVVIKDPQVTSAIKELLKRGQPYVGAFLLKDEDLDVDTITSLDQVHRVGVFAQITSVFPASSNAKDGSKEDAGLTAVLYPHRRIRIEELLPMGKPKHLEKGKEEAGEGDSAVTAAVVKDEGPLTEPLKQKSEKKSKKSSSKESSKDSSKDTSKEGVMKDKAPESDVNKKSDFVEDTAASSEKQQTQYATSFLANDYAVSLVNVDNLQDTPYSKKDQVIRAVTSEIVSVFKDIASLNPLFRDQIASFSMSQSAGNVFEEPAKLADFAAAVSAGEPNELQDVLECLSVEERLQKALLVLKKELMNAQLQNKISKEVESKIAKRQREYYLMEQLKGIKKELGLESDGKDKLVEGFKEKAAKLAMPAGVKKVFDEEINKLAHLEPAASEFNVTRNYLDWLTQIPWGQRSLENYNVKHAITVLDEDHYGLQDVKDRILEFIAVGKLRGTVEGKILCLVGPPGVGKTSIGKSIARALDRQFYRFSVGGLSDVAEIKGHRRTYVGAMPGKVIQALKKVQTENPLVLIDEVDKIGKGHQGDPSSALLELLDPEQNSSFLDHYMDVPVDLSKVLFVCTANILDTIPGPLLDRMEVIQLSGYVADEKVAIADKYLSPTAKTAAGLEHANVNLSKDAIESLIKNYCRESGVRNLKKQIDKVYRKAALKIVKDIGEDHFEQQPGDTAKALSVEEGAPNVHEKAGEESLDPPKSAHEKGEEISSKERKAISIPDSVKVDITAESLIDYVGPPVFHSDRLYDRTPPGVVMGLAWTSMGGSSLYIESVLESPLTPKSSPKLNKTGQLGDVMKESTTIAYTFAKSLLANRFPKNGFFEKAQVHLHCPAGAVPKDGPSAGITMATSLLSLALNRPINPNVAMTGELTVTGKVLQIGGLKEKTIAAKRSNVNTILYPKDNQSDWDDLPDHVKEGMTGIPVDHYDEVFKICFEGLKADEAESVWTDKLKEDTNSESKTATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLG7</accession>
    <name>A0A8H7PLG7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLG7"/>
    <dbReference type="OrthoDB" id="2131431at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="405" mass="45478" checksum="CBD8BCBEBF89FB9D" modified="2022-01-19" version="1">MNPNDQINTVWRVCDNNPEGVCHCDWRLTINNCAEEKVMRIIYIINVALSSLTVIFGKCYYDYDIPYIIVRDEYQANSIIQHAIVFSGFYMLGKRIIFQGHSLFGRGDSARKGIFRPKPVECLLLMITIFSVLRLVSSLVLVLDIAPTNMIFRSFIFEIPWQWGYGGFVLYLIGIAQTLAESHKAIATGWLPSPILVDIIGFTQLLFPFVVNNTCSIIAGAMLNAGNDKVAEIFIRLLYIFWFLEDSVLTLAVVWAGSRLISVLNRHLYQFRVTGDRYTSIKGGIMKIKLIIVIAAIGLSGFAAFLLLYGILRPMIMTSTVGSAVLGGIWTWLGAFMCISCEAAVAIRYVFFPKWPTPKLVFQILQQIRTPEDPAIPATTIPLNTPRIILKAMEEIAPALLLLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMY8</accession>
    <name>A0A8H7PMY8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_007612</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMY8"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14836">
        <property type="entry name" value="AP2_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043532">
        <property type="entry name" value="AP2_Mu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="10">
        <location>
            <begin position="168"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2176958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="395" mass="44911" checksum="2A009C3102A5D8DE" modified="2022-01-19" version="1">MISAFFIYNQKGEVLISRLYRHDLKRSVADIFRIQVISNTDVRTPIITLGSTSFFHVRHENLYIVAVTKWNANAALVFEFCNRVINIGKAYFGKFDEEAVKNNFVVIYELLDEILDFGYPQNSETDTLKLYITTEVVKSERAVEDSSKITIQATGATSWRRSDIKYRKNEAFIDVIESVNLLISNTGTVLRADVSGQILMRAYLSGTPECKFGLNDKLLLDKDAVMKSNPLRRPNAVEIDDCQFHQCVKLVHPVVNEIGRTRVEYKINIKANFSPKLYAHNVVLKIPTPLNSAKVEVKVGAGGKAKYAPAENCIIWKIPRFQGQSEFSLSGEAELSAMTHKKAWSRPPISMDFQVLMFTSSGLLVRFLKVFEKSGYQSVKWVRYMTKAGTYQIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PN12</accession>
    <name>A0A8H7PN12_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PN12"/>
    <dbReference type="OrthoDB" id="2330049at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="256" mass="28348" checksum="DE74415A1E1A9E2A" modified="2022-01-19" version="1">MDTDIVAPGEKVAMESLANTIDPRRLRSCYSAHSDFGSRAIHSRPTASPNRMEHKANGHAKFGITDERPSFDIQTAHVASISVKTPAAQLVYDHFIGYAAQLMRENEASLDNVIQFVDFIIETVKISSGWSDADRKRQFEMALATIDSNAMTETFSTDKYVELNRLAEQFILAQNMPASPSTRRAGGGDLIVARPLASMYSTEDVQTIRGMAPLVYVSDPLSRDDEEDFDSDMYDYDDSFTPNGGSDTDESPILML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PP16</accession>
    <name>A0A8H7PP16_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_007867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PP16"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2177210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="89" mass="9513" checksum="D2F3CB24C92B2BFF" modified="2022-01-19" version="1">MENLMSGRVVREIRDKCEGEVISLGICEQCLIATACGFAFSDSSVALAVALAVALAIAFADAEVSTGDEFGYAKHDDQDEANLKQMPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PP88</accession>
    <name>A0A8H7PP88_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CoA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PP88"/>
    <dbReference type="OrthoDB" id="5138418at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303:SF2">
        <property type="entry name" value="COA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="139" mass="15115" checksum="4C7DDFE245EE3C59" modified="2022-01-19" version="1">MNTIAREFLLENKHFAVAGASTNRSKVGNQVLRWYQNNNLQVTPINPREPNVEGLTSITSVSELPDPKNTGLSVITPPTITLKTLQDAHAAGIKYVWLQPGTDNQEVLDYAKNAGFKFVSGGPCILQIGTGLLQQGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPF8</accession>
    <name>A0A8H7PPF8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPF8"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019853">
        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF65">
        <property type="entry name" value="ALDONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="2">
        <location>
            <begin position="14"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="2">
        <location>
            <begin position="131"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="2">
        <location>
            <begin position="201"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="352" mass="38642" checksum="DD11D3974C649DDF" modified="2022-01-19" version="1">MKLEVYPDDDRFLLGEGPLYDEETDELHWIDITGCAIFTHRHGEPTVRYDIGEKPGVIAVRSKGGFVVASKNGFSFLKDGKLDHIVSPFGKDHPILRMNDGAVDCKGESNAADRPECQNLVVVLTRNSVLSGRFWAGSMADVEEHHDANKNRGILYRLDPDLTCHAMDDGIGIVNGKICSGQTLPQIILSRNDLLPTAFADILCLIGVCWSPDNSVMYMADSEDKKIYIYDFDAESGNISNKRLFLDTAISYPDFNPDGACIDSEGYLWWALWNGSRLIRIAPDATIVEEVTVPALRPTAPCFFGKDLSSLFITSSGAQEGGVQEGGVQEGGKNFVLKDVKVKGLPKFKFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPH8</accession>
    <name>A0A8H7PPH8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPH8"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="44" mass="5067" checksum="F41E2273B775D5E0" modified="2022-01-19" version="1" fragment="single">NKDTPWFRHEIVIYPWPASVLCHLAVTSRTAVIMLFITDARLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPR9</accession>
    <name>A0A8H7PPR9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sucrase/ferredoxin-like-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_007976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPR9"/>
    <dbReference type="OrthoDB" id="10253744at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF14">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2177319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="32868" checksum="6AFF67979A525375" modified="2022-01-19" version="1">MSGLINAFKSAIGRGQDLLPPSDLLVTEEDCNACPNPCHDHKQFPSYLKLDNHTPLLGSTKPYSRHILIATGKSDWASHIDEEKDTVAAALLHHMNKVSPPFRIVTTNSSLDAMHSTIPDSTDIIVLPDNILVSNVTVNNVEQFYDLFLATPLPSKSDAELPDTKGHSELKVIKNMYTSMILLCSHRRRDKRCGVTAPILAQEFDHILRQKDIHEGEGGVTIVMVSHIGGHKFAGNVILYTHEGRRGIWYGRVNPCHCEAIVEQTLIEGKVIKDLYRGSMTHSFDDEKTTAEVQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PS56</accession>
    <name>A0A8H7PS56_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_001777</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PS56"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="167"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2178930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="284" mass="31623" checksum="0E8EF0E815F9CC0A" modified="2022-01-19" version="1" fragment="single">MSTDKNHDANGQMRFIDYTYMNFTHAAISADPIVEDVPVDSKHKQVANIKPLEPFQPGQTCDNVAGTRLSKTSSSSRLPQVVQHMGTSSLYSSSMHSISDAIYDIGMMLGPNTAHSQTPSASGLDYPTGYYQEMLSPEEAQPTNKQYLIDNALVQDDMIRLSPIKFCSNCFTTETPSWRRCSEGKNLLCNACGLYEKLHHTHRKICLHPDGSTKIVRHNTAEAQGGCAVCGTTFASLWRKLDRKCYCNACVIRFGIGHTKRMSLPHIWSDAVSSQRTVDYPSYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSZ4</accession>
    <name>A0A8H7PSZ4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="3 10">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_002055</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="3 10"/>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSZ4"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2179205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="246" mass="27721" checksum="28210317841BEAFD" modified="2022-01-19" version="1">MRDSSPVGRPQPVHTFVDPSEGKLFDGENTPQNIATYGFGLGLLAGLSGVLAITGHGYCQMWLFLAGLAVFHFLEYLATALFNGPKLSLDSFLINHSAHYHAAHLAGISEFLLEAYSFPSWKGLGYVNWIGLILMISGQAARTIAMFSAKSNFSHHIVGYKAPDHVLVTHGIYSIMRHPSYFGFYWWALGAQLLLMNPVCFLLFIYWLHKFFSERIAYEEHTLSRFFGQDWETYKKKTSTLMPLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTQ2</accession>
    <name>A0A8H7PTQ2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T4 RNA ligase 1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTQ2"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019039">
        <property type="entry name" value="T4-Rnl1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09511">
        <property type="entry name" value="RNA_lig_T4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T4 RNA ligase 1-like N-terminal" evidence="3">
        <location>
            <begin position="63"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="916"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="436"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2180137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1067" mass="122668" checksum="2A87F359C7C5AABF" modified="2022-01-19" version="1">MSNSTVNEVVSALYDIANSTDKKKAKAIRAKDFSLNLEGITLTSWNMRESDYKSDPCPFPLMARGLFTTETAEGKNIIVLRGYDKFFNLGETKYTQWIWLEENTIGPYELTSKENGCIIFIAAVTESQLVVTSKHSIADPVDDEHHHAGVGYRWLLKHLDSAGRSITELSAWLHSQNVTMVAEDLLLTQSNSLQLCDDDFEQHVLEYPLEQRGLYLHGINYNEVVLRTMASDQVREIGREWGFRTVPFQTLPDVQSVRKIEEALRQEDEFENRRVEGVVIRCKRKDDNTTFFFKIKNDTYNEWREWREITKAILSEKNYRCRYERSIYYAHWVKARLNDHPDWFSEYKHSKNITFIRDEFEKYWDEGNLLESGDPVSGTSSLYMPITIHKNRKKRAATDTILEKGKGLPTGQNSKSSPTLSNLRSIGRLGSSTFNSLGSSSVTSSSSSDSSDDKSEMLTQEMAGVRRALDLFLNSRIREAEEMIIPNKDSSMYWSLGFAFISFLKAMMTFQTNDVETALDALKHTIQISGQSRKKDTGFMDSFTSWMKGGNGLASLKNMTKLQRHAELVYAESYLLKAMLSIVHDESYLGFLREGLNIRNSYNIYRSLQKFVEFIEEEVSAGRDVSAYEIDDHFTSGVALGVGCFNLMLSLLPSNILKVVEFIGFSSDRAYGLRQLESIGGWGPYHDDTSMPLPEKQGADEGLRRQFCDMALIMYHVVIARAMPTVDTDISFAEDILTYNLEIYPDGVMFLFFNGKLKSSEGMIDQAIEQYHKAIDIQKEWKQLHHICYWELGMCYMMQCKWKSANECFTILYKESNWSKAVYTYMAAVSLYCSMDDINDEEDKKEAMDQVIELMQLVPKKTQKIAGRSIPVEKYVARKARKFLLQQNYLLLPDLEILSFNNVYECMPQDILEFKLKVLNDTIKELDDKIESSEDQYDNIYDDYCLVHYLRGIVTRLLAYLPSTSEERRTELLELHQYSMEATFENAPQIRLDHWIYYFAKFEQACVSLKEGEYALAKKDLQAVLKAPEKGYNVGTGPGAKHKYSMENVLLFKCHNALHEADTLSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PU04</accession>
    <name>A0A8H7PU04_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_003601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PU04"/>
    <dbReference type="OrthoDB" id="2350333at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2179818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="469" mass="54860" checksum="4452F2091D7EFDEA" modified="2022-01-19" version="1">MTRSQTSRKKFIFYCHLCKRTFKERHRWFSHLAKKEGLDISNDLSDEEHAEILKRTKEKAKGMSGDIWICFSCDSLEKSEGDLRVHLQDMHNVPYLSNDDYSQQEIPCDDSDLENLIVSEFTEEEHDPGEVPEFEAYDDDDDDDECVTNVEKDFLSKRVNDIQRHLTKKSDLLNPFKYFVFDLTGRHCGTKACLMDMYKKLQKDLWSKISYERHQMNDRQRAILMNMMNISCEDDIDQGLAHIAYLSNAELSKCRSHLSESTHIMANIASYFTILEPKNRKWSGQWGETSLKASADRRNWDVDPSEKSRIGQKTDYILNYLGMGVDAELFIGEVSGGLPKACNGKAWYDYLIKLVLGARDCLLRLQDYWGKDDDRVFYFFQVHGFRFTLYAMDNYDGYWRVIMVDECYLSRSDDDVARRADLYCILRGVFKTIEEQALKLNMLGYNDVNGSKRKMVYDDRTIVKSPKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PU81</accession>
    <name>A0A8H7PU81_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 188</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_003980</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNEP1R1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PU81"/>
    <dbReference type="OrthoDB" id="5599171at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071595">
        <property type="term" value="C:Nem1-Spo7 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019168">
        <property type="entry name" value="NEP1-R1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005605">
        <property type="entry name" value="Spo7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996:SF1">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03907">
        <property type="entry name" value="Spo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="180"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2180191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="220" mass="24935" checksum="CC5C56F812A8CBC0" modified="2022-01-19" version="1">MATVEEQPPPMSSGPVTQTLDTSSGPPPSAEQVSKVANRHMDTATYRDLVIFEERLRGNMRRLQRRKTKYEAILGLFVTLGAYFAYAVFIHPSSISLLAMFNKISLLVFVMLVFLFFWTGMYREKVVYAAKFVPHCNKALRSFNLHFNRDDNGQLSFYKKIPKPFQEGFNTYRQHYYQRKKARKAAKAAGTAKSTSSSNAGAKQNRNTSAPSDSPRIKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVK6</accession>
    <name>A0A8H7PVK6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVK6"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043456">
        <property type="term" value="P:regulation of pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517:SF1">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23770" checksum="CED9289870F6C4C6" modified="2022-01-19" version="1">MSLSLTGHGVQQAQLVGERLKNRQFTVIISSPLKRAFDTAQAIYNDQPGKPKFFTDARLMEVHMGEFEDKNWNIYKLPKLDGVPYRHRRFPHGESRHDAYLRVSTFIEDLFTEYPVNDSSDVNILIVAHGMVLSEVSNALHSKQKVPWEHIRWHNTAVTTLQLHPTGGLNVLEANDTSHLERLVRQRGGIGSASHDPSQTKLTGYFGKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVM5</accession>
    <name>A0A8H7PVM5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_003818</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVM5"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02661">
        <property type="entry name" value="Peptidase_C19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000119">
        <property type="entry name" value="Ubiquitin specific peptidase 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF758">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="52"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="489"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2180031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="544" mass="60351" checksum="9321621A593B1D5A" modified="2022-01-19" version="1">MTNGKIHKANDRSTKPAASKPTQTVTPTKDNRVLFDKSLLSIRWRSNRRIGPGLVNVGNTCFLNSTLQCLTYTPTFAEYLLDRLHSKSCKVKDFCAMCALQDHVQRCLLGDKSGGGGGVISPRNITGKLRAISSHMRLGRQEDSHEFLRHLMQAAQKSCLAGLGKLPHSVQETTAVHQIFGGYLRSQVRCLKCKAESNTYDPCLDLSVDINTSNTLHRALRDFIKVDHIGGRDNKYKCSACHSLVDAEKQMTIHQAPIALTVHLKRFTYNWRRGGMDKVSKHIEFPERLDISPFMSHTTRKTARPYELYGVLVHMGGGCHSGHYYAYVKNANGKWYCMDDDDVRPVSIQTVMRERAYMLFYTQEASGEVNAAIKVRILASSKRTANEAGINENNTVHEQRLKQAKSDVKPEPAKPVAPMEIPKVSVTPAEEPAPVPAVASPPEPANILDGVGGLWVVRSIYVPRKSLRGNVSPATISSALSHTNRWTVRPLNEATPPPVNRLLQRNSSNMSISSMGSTNSSPSGSDEETSKRKPKLVSQWQVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVX0</accession>
    <name>A0A8H7PVX0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome assembly chaperone 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_008801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVX0"/>
    <dbReference type="OrthoDB" id="368507at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032157">
        <property type="entry name" value="PAC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33559">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33559:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16093">
        <property type="entry name" value="PAC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2181218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13185" checksum="EE338F2C135B5EB4" modified="2022-01-19" version="1">MEPRFKIHQQTEVFSQKPIHFQITIMNKSVMIWVGRSQDGLGDLSVGMPALGQNPVPAASNLLTRDLSDVSVDLSRRLALRYGQQFFVSMNLPSDDQLMLAFVEKKISLILKDILVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PW81</accession>
    <name>A0A8H7PW81_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_008981</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PW81"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="652"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="679"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2181398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="712" mass="81638" checksum="24E440F99BF7769F" modified="2022-01-19" version="1">MKFGEHLRKQRLPQWRFFYLDYDGLKAVLKDGSSQEAEWTSKDDQQFVDRLITELDKVHSFHALKHGEIQRRIRSCQRRIQTLSNSPHPALSEYLSIQNEITDITCEVQELFWYTRLNYTGFLKIVKKHDRYASHAPRLREQFLMALHNRPFYRSEVFSQLTAELASLYDHARINSASSFNSFASMTPPSIITPIARQHQPLVYKTTKYLVHLDNVMDVKTHLLKYMPLISQNSSPTPQSVLNDSIPSSQEYKPSLAQAIGECHSDETISSIYLDDQHFSSYMARIQFLAEPQTIRLRWYGSDTTDLHVERKAYGYGKHETVEGLPNSQDELNESSSKDRHPIKAKWVPEWLNGQWDARERLSKAYQKQRFNTFDWVGEEQDDEAHRIQNVAKDIQDTVQSDQLRPVIRTVFRRTVFQSQDESVRVSLDTDVVMAQEFGWNDPDSPIGDHWRRNDVTEITANEDYFLDIPPDHQNANDIYKFPYAIVEVKLRASQDVSLTDTDEPDCVKNLIRARLMEPVAQFSKYVHAVSILWEANVPLLPFWLPQLHAGVYCPTGIRLTRPYHSTAESADTSNATNDSTAHRSDDRGILNLSPAPPLLPRKINHHLSLPMSSNVPSLTETTPLLGSPTGEQVLLMTPLPRRTIAHSIRRLVQAVYPVVLVILIVAIALVIAEIEDRMLANVLGVLVAAMALAGFCLWMFVFKTSLTQTTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWR1</accession>
    <name>A0A8H7PWR1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Stress-associated endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_008722</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Interacts with target proteins during translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation and facilitate correct glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the RAMP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWR1"/>
    <dbReference type="OrthoDB" id="16679at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010580">
        <property type="entry name" value="ER_stress-assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06624">
        <property type="entry name" value="RAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2181140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="63" mass="7164" checksum="B942200A8A4C3135" modified="2022-01-19" version="1">MATTPTLRKKNAAYQNNVNKRGHVKETLKPKKEWNLPVSMPVLVVLMFITFGGAFLAILELFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXB0</accession>
    <name>A0A8H7PXB0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_007269</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXB0"/>
    <dbReference type="OrthoDB" id="601405at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22905">
        <property type="entry name" value="HFD_Dr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000019">
        <property type="entry name" value="Negative cofactor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042225">
        <property type="entry name" value="Ncb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138:SF1">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="54"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2182339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="178" mass="20251" checksum="6155BF7D23EBF35D" modified="2022-01-19" version="1">MSDNERTGPAVDDELSLPKGMDRSQQRSVLRSAQKPLRLSVVIIAKHIVNILGLATVQKLISEMMPGDIVCAKDTRDLLIDCCVEFIHLIASEANEICEKETKKTIAGEHVIASLQALGFEDYVEEVDEVYKEHKKQQKDRDKRSTRLENSGISEEELLRQQELLFEKSRLKFEAQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXC2</accession>
    <name>A0A8H7PXC2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_006924</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXC2"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000001">
        <property type="entry name" value="Prefoldin subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2181998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="182" mass="20942" checksum="3348B749FCF022B4" modified="2022-01-19" version="1">MAQVQTNPRGIPTSPFVERVEDYVSAAEPVEVVLKKFQEAISKYKFMEINMLQRRKILEEKIPEIQKSLSTVEFLIEKRDSDDDTPTMETEFELNDTLYARAKIEPSGTVYLWLGANVMLEYTLEEAQELLKSKLGTAKTSLSNAIEDLEFLRDQITTMEVNTARVYNWDVKQRRLAKAQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXG1</accession>
    <name>A0A8H7PXG1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 39C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXG1"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="805"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2182157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="840" mass="94604" checksum="41F44962F7861905" modified="2022-01-19" version="1">MSEETPKDLKETEQAVEDAFQFNDDEAFHDVVDSLDIETPTPENLLQNPEALKEHVEISEEVAEEEEVKSANVPEQEEEKHEELENVVHALQDSFQQMATKGDADKPKDDSELVGLGLVLSESATDSKIDEDIQEEANGTEFEDGLPKINTNVNAVDGEFIPPTPGTPPNRSPFESTSSIEDSDDIETYSANLLALNKVDIKNIGPNNLDAREQEEADEPVLAGMAHLFNNRFMKAKKVFESEADTNPLFGFGLGYMAFLKGKFGRAGDEFLEDNTFEEKEIKVAIDILSQTYLVANAQIDAATKKGFGGSVAQYVSSYYTYIKHTRSKSMPHATPATSDQEVKFLPNGVLRAHVIKAECCLQIAILQLAQETVVGYIKCGLNLRRAYTSYSLVWQEYKRMGQAYNEYMDRDTISGIQFGIGAVHLVLSTLPTKILNMVSAFGWKADKHLGFALIKLCLDNDRIRSPSASMLLLGYYTVLTTFAPQILSPIYTQPAIETLLDAQKKYPNSAFFLYFAGRTSRLARNLPLSTQSFKYASEISNAEWVEVDIRQVCDYEIAVNNLMQLNWKEASDLFEKLCSENYWSPIIFKYLHGVCLEQMGMRTEAILAFAEVSQVAARKTGSKSNMELYALRKVESFQAAGYQDLPITCPALEYLYINNSFECMEHTQLNDAMDTVDIALEEIQEREKAEYTVRANEIMPNIDPPDYYTHRGTLLLIKSAILNALGRHQQSIIHLNWIIDHKDRMANEKWIVPYAYWEAGLVTWINGDKLKSRILWETALTQTKFDFEYRLAVRLNLAISRAEDLGTPKPERPKPERGPSTNGRKRLSLAAVRSTTPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXM7</accession>
    <name>A0A8H7PXM7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_006932</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXM7"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2182006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="328" mass="39029" checksum="B993C8B1E1962046" modified="2022-01-19" version="1">MSAFRETASRRQEDKRRSSQSADTMRDGHKKDGNIHNVPHTVDQQERVKAAFVVLVRNRELDDLRSSMSHMETTFNWKYNYPWIFLNEEPFTQEFINLTRSMTKAEVSYGLVPKEHWSYPEWINQTHAKQQRKEMARKGIIYGGSESYRHMCRYQSGFFYMHPLLDDLEYYWRVEPDVKFMCDIDYDPFAYMKTHKKKYGFTISLREFKETVESLWSVTRVWMDANKELVVPSDHPGNLMKFISEDGGSTYNMCHFWSNFEIASVRFLRSDAYQSYFRHLDEAGGFFYERFTSSMIWDTVMVPSNTVQRHRIGLRMASVIAILEQILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXP1</accession>
    <name>A0A8H7PXP1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peroxin-5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_007119</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXP1"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF0">
        <property type="entry name" value="GH08708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="587"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="621"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2182192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="749" mass="84093" checksum="23733976BBF9C04A" modified="2022-01-19" version="1">MAFPQLAGSGADCGPSNPMSGLMKQFQQDRSLQQDRFIQDQAAESSRSAFRTRNQGRPMMGSPVSILLMMTEEFFREEAVTKGPHNRFEFSELNKELENIRPGTVDAPDWAADFMREQPMIMNDHHQMEDFENVFQQHHRMREIQAGNHGWEQEFSNFQQSHNQSLAPQEIEAFERAFEEAKQGIAHDKYKRLLLLNSPQTLNFYKLLGSGVDWEKEFASQEDSWASEFNKQEEANVMAGSEKEALAKTAGMLLDSIDVNSNPKFKSSNFLSFMRQLRDSEVSIEGSKVVPNTQQSESSWASEFAGGETSTGWAKEFSQGLEGAKDGNMWSDEFAKGAERGWVEDFTSTAGQSSAPANSSTAAVQDWATEFNNDPVNAAQMEEAFSKGTEFNDWVQQYHQNIAHLKTAQDAEWEGMQKDWDKYKPDQGLGYRADNAEFNDYGFLPNNPYLSRAMPVDGGHNLSDSILALEAKVQLDPSDATSWQQLGFRQQENERDSAAIAALRKAVTMDPTLLDAWLGLAVSYTNENCRADAYDCLDAWLQHNEKYKHIATSRGMKSKMVAADRHAFVTNLFLEAARSSPGEEMDPDVQVGLGVLFNVSEEYQKAIDCFKAALASRPQDYLLWNKLGATLANSHETPAAIDAYFNALEINPSYIRARYNLAISCINLGQHKEAAEHLLTALALQQSSESNATEAPLIDENGNQYTVPGGMSDNVWDSLRMVMFMMNRQDLATQCDARNLEAFRGVYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PY08</accession>
    <name>A0A8H7PY08_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="12">2.4.1.132</ecNumber>
            <ecNumber evidence="12">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_007273</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10 12">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11 12">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="12"/>
    <dbReference type="EC" id="2.4.1.257" evidence="12"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PY08"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03805">
        <property type="entry name" value="GT4_ALG2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="14">
        <location>
            <begin position="23"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="13">
        <location>
            <begin position="219"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2182343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="465" mass="52638" checksum="649FEAE799103E89" modified="2022-01-19" version="1">MSSKQEGRQAPLKVAFIHPDLGIGGAERLVVDAAVGLQQRGHEVVMYTSHHDSNHCFEETRDGTLEVLVKGNTIIPRTIFGKFYILCAILRQFHLCFSLLREHKDSYDVLFVDQLSACIPLLKLFCPSKIFFYCHFPDKKLARHETWLQNAYRAPVDLFEEWTTGMADTIVVNSDFTAGVFKRSFPSILKRPRTLYPPINFEAYDKVADINDPSVKILVSDKKLIVSINRFERKKDIALAVHAFAKLRDDKEISAELFSKMRLIVGGGYDPRVSENVDYKSELDVLATKTYGLKTFTLMPKSVDLIPDGTQVLFLCSFNDAQRSYLLSHAMVVLYTPSNEHFGITPVEAMYAKAPVIAANNGGPTESILHEKTGFLLPPTPEAWKDGIKTIVTERVDGTKMGQEGRKRAQEKFSLTAFVNQLEDVLDELASGGRPTKHHYDNVEYGVRVTVAIVFFGLWLKYWWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PY12</accession>
    <name>A0A8H7PY12_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_008814</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PY12"/>
    <dbReference type="OrthoDB" id="193716at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="128"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="341"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="564"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="569"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2181231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="679" mass="76914" checksum="824BAB6C70491617" modified="2022-01-19" version="1">MQVAARLIARSNGFMATAASARSFSVIPLSRSGLKGTGFLSQSPALKTIRAQKTMASLMSHSKVGYSAFHTALKVANAEASTVVAENETPVAELKNFDEITGLNPLTQQAIEKIFQYKQMSKVQEAVLCQLPLEKDMFVKAKTGTGKTLAFLIPALESSFAGQSFREIKESVGTAILVVSPTRELAQQIAEEAKKLTKFYPLKVHCLVGGESKRKQIRDLDRGRADIIVGTPGRLIDMLRSVRHFKRSCESIKTLILDEADQLLDMGFKDEIQDILREIPEKRQTLLFSATLTPHIRQNIVQFALSKDHTLLDTVDPNEINTNLQVKQDYYIAPFGDQAAVINDIISNRASAQNGKTMVFLPTTRMTEMYAEIFRDLMGPKRANNVYELHSKKSQMQRTKISDRFRAARPGSVLFTSDISARGVDYPGVTLVLQIGVPSSREQYIHRLGRTGRAGKDGEGVIVLAPFEEPFIRNDVADLPLERKDATAALASSEDAREVIHEAAAKLAPNFIDDAYMSFLGYYSSRMPVLNQPRSDTLVHAKQFLHGFGVTEVPHMSPNLLAKMGLSSKSRDRNNNSRSRDRPRFERRDDRPRRPRFDDDDERPRRPKYDRDDERPPRRPRFNADGDRPPRRPRFDKDDDRSIRPRFDRDENRSRRPRFEQDKDFSISDKPRSKRTYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PY26</accession>
    <name>A0A8H7PY26_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_007402</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PY26"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="38"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2182472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="434" mass="47198" checksum="06E67D666057D0DB" modified="2022-01-19" version="1">MKDSIKSTPPSPIQELDVTSDASSFDDVNDPSKPRPNGGSLWQAYVNVVCIVAGTGVLSLPYALKQGGWIGILIIFLAWFMSMTSGNILVKCCYAAGPKRLYSYKAIGDAAFGPIGGWIIFFFNFIILIGASMLFFVLIGGNLHSLLAGTSGELTMPLWVIIPGICVAIPFVFIKSMKEISFTSAIGALATFTVVLIVLISSLQYRPSGPIYHDNVIWNQFPIALSSIAFSFAGNMVYPNIEHSMKNPKQWNKAVYLGLSSCAIMYFLSAIPGYYIYGTTAQSPIYNNLTNRGAQMAAQVIITIHVLLAVPILITSLALDIEGMFNITVDRMGKTGEFLARASIRITIMVAVCVVAIYVPYFGDLLSLIGSFSNCLLIFTFPVMCYLKLTGIRNKRVHELAWYALTVLMGIVGLIFGTIDSVKALIADFQGDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZ04</accession>
    <name>A0A8H7PZ04_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007313</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZ04"/>
    <dbReference type="OrthoDB" id="74910at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000003">
        <property type="entry name" value="Fumarylacetoacetate hydrolase domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="12"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2182383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="231" mass="25050" checksum="946809EEE42A22D3" modified="2022-01-19" version="1">MSARNFFNTGRKIVAIGRNFSEHAKELGNAVPTTPFFFLKPTSSFLANGGSIEVPQGCDVHHEIELAAIIGREARDVPASKAMDYVDGYALAIDMTARDLQAKAKAKGLPWSAAKGFDTFTPIRQAIFIDFIPKSAISDPQNVDLWLKVNDTIKQSGNTKDMIFETSALIAYVSTIMKLEAGDVLLTGTPSGVGPIRPGDIVTAGLKPFGAEKDLINLKFDVIERKGNYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZH7</accession>
    <name>A0A8H7PZH7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_007211</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat PWP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZH7"/>
    <dbReference type="OrthoDB" id="3142434at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000602">
        <property type="entry name" value="Periodic tryptophan protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000938">
        <property type="entry name" value="Probable periodic tryptophan protein PWP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="184"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="344"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="386"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="472"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="514"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="7">
        <location>
            <begin position="748"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="643"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2182284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="873" mass="97700" checksum="49CD4F28FC56E4E0" modified="2022-01-19" version="1">MKSDFKFSNLCGTVYKQGNLVFTPDGNSILSPVGNRVSVFDLVNNKSMTLPFEMRKNIITIALSPQATILITVDEDGRALLVNYPRQIVLHHFNFNEKVNDIKFSPDGKFFAVTHGKQVQVWRTPGFNREFAPFVLHRTYTGHYDDILHLSWSSDSKFFLTTSRDMTAHIYSLVPTEGFTHMTLSGHRDAVLGAWFSKDQKAIYTVSKDGALFHWRYATVASILNQEESDEEMEESKEVEEETKPADQVRWRIQERHYFLQAGAKVKSCAFHQDSNLLVVGFSSGIFGIWELPTFTNIHTLSISQKKIDTVAINATGEWLAFGCAKLGQLLVWEWQSESYVLKQQGHFYDMTSVAYSTDGQNIATGGDDGKLKVWNTVSGFCYVTFSEHTSGVSAVEFAKQGQVVFSASLDGTVRAFDLVRYRNFRTFTSPSPVQFTSLAVDPSGEVVCAGSMDSFEIFVWSVQSGKLLDVLEGHEGPVSSLAFSPTGLLLVSGSWDQTARTWDVFGRKKVVETFKHTSDVLAVAFRPDGKEIAASTLDGQISFWDVEDAKQTALIEGRKDISGGRKSTDRVTAENSASGKCFNSLCYTADGTSIIGGGNSKYVCIYDIATNILVKKYQISMNLSLDGTQEFLNSKKMTEYGSKDTMVDDDDQSDLEDRLDNTLPGTASGDLSVRRTRPEARTKCVRFSPTGRAWAAASTEGLLIYSLDDTIIFDPFDLEIDITPDSVLETLEAKEYLRALCMSFRLNEKNIIQQVFEGIPPKDVELVAQDLPEKYLERLLKFVGVHMESSPHVEFHLIWVTRLLMAHGRYLRENRGQYQTIFRTLQKALGSVKEDLASLCDANQYLLKYIITQCQKSSNSSMEGIQQNLLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q103</accession>
    <name>A0A8H7Q103_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein UXT</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UXT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q103"/>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23158">
        <property type="entry name" value="Prefoldin_UXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003994">
        <property type="entry name" value="UXT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345:SF9">
        <property type="entry name" value="PROTEIN UXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01502">
        <property type="entry name" value="UXTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2183388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="17125" checksum="A0F79A1E7A7422F4" modified="2022-01-19" version="1">MTTNEAADFTAVLQKYDQFINDKLKPDLKATLDSRDALYDLTSDLKLKAQIETIQTNDLKEMKTMVDLGSNFYAQAKIPDTRYIYINVGFGFHVQMTLKEALVFIEKKNKQLQNRADKYSEEAAKIRANIKLVMRAIQEILQLPDADEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q296</accession>
    <name>A0A8H7Q296_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="19">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">INT43_000405</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="function">
        <text evidence="17">Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 19">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="19"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02736">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02583">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000174">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000189">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035698">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035697">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01025">
        <property type="entry name" value="PR55_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 19" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 19" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="14 19" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0853">WD repeat</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="20">
        <location>
            <begin position="687"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00055525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00058108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG2184496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1832" mass="206475" checksum="9DDFAA5B938B7C5D" modified="2022-01-19" version="1">MAEPEHNWKFAQCFGDKGDSDDITEADIISTVEFDHTGDYLATGDKGGRVVLFERNESKRGCEYKFHTEFQSHEPEFDYLKSLEIEEKINKIKWCRRQNAAHFLLSTNDKTIKLWKVFEKTLKVVQETPLHDGIMLRPSLPTSNDLGTSPISANSLRLPKLTHHDTIIAAVPRKIFANAHAYHINSISINSDGETYISADDLRINLWNLDVSDQSFNIVDIKPVNMEELTEVITAAEFHPLHCNLFMYSSSKGTIKLGDMRESALCDQHSKVFEEEEDPSNKSFFSEIISSISDVKFSKDGRYILSRDYLTLKVWDINMENKPVTTINIHDHLRNKLCDLYENDCIFDKFECTFSGDGSSVLTGSYNNYFHIYDREGKSDITLQADKSAFKAKRVGSAKNKMTMTGNRKRDDFNVDAIDFNKKILHASWHPKENSIAVAATNNLFIFTKHIQFGVLSPQEMVKIAEFEVTQRDLYNMPDRTPVRHGVLDMRLVCIITKMGTSSKDGTCETCGQKMADCAGHFGYIKLVLPVFHIGYFKAIIAILQEICKTCSRVMLEETDRRTYLKRLRTPGMDNLTRERLVKAINTKCRKYSNCPHCNAINGTVKKVGALKITHDLFKRETKKNESFKRAFEKSFAESIKTMPEIKSHINKAQDDMNPLKVLKLFQRITPEDCELLGLNPEHGRPELYIWQYLPVPPVCIRPSVPQDDGSSNEDDLTAKLTEIVFTNAIIRAGLEKGITIMNLMEQWEFLQLTAAMYINSELPGVPSANVGKPTRGLCQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNMRIDQVAVPERVAKILTYPERVFEHNIHRLRQHVINGPDIHPGANYVQFAGSGFKKFLKFGNRHAIAAELKIGDIVERHLSDNDVVLFNRQPSLHRMSIMAHYAKVKPWRTFRFNECVCAPYNADFDGDEMNMHLPQTEEAKTEAIELMGVKNNLVTPRNGEPLIAATQDFITAAYLITRKDRFYTRAMFVQICSMMGDAELKVTIPPPAIWKPQRLWTGKQIFNVLFRPNTDSNIIINLETKTKSFIKSDKRANDLCPADGWLVIRNSEIMCGLMDKATVGDGNKNSVFYIVLRDYGPIESAKCMNRLAKLCARWLANQGFSIGISDVTPGERLRSIKEENIATAYKKCDEVIKDFENGQLETMAGCDEEQTMESQVSGILSEVRGALGKVCMTELNNHNAPSIMARCGSKGSQINVSQMVACVGQQIISGTRIPNGFQDRSLPHFLKNSKQPAAKGFVRNSFYTGLAPYEFLFHAVSGREGLVDTAVKTAETGYMARRLMKAFEDLTTFYDLSVRNSEGAIVQFRYGDDGLDPMTIEGDGIPVEYERNMQHVRNSISIQKGDAALLPWQIRLISEEEVRRPIWKVNCMESFIQSTLKYINNNVVERLVKIRQMYKLQAGVAIPSEDYMDIDIDEDITDDVRAIVNNKFTITERQLRGFLNVCLSKYMKAKIEPGTAVGAIGAQSIGEPGTQMTLKTFHFAGVASMNITLGVPRIKEIINASKIISTPIIRGQLVSPHDVRAARMVKARIEKTTLGEIAEYIEDVFAPDGCYLCIKIDMPAINKLQLEITLNEIATSIANAPKLKISNAVYASQPDIIRVMVAETEEKGKEKEPLYFKMQRLKRALPYIIIKGLPTVVRAVISEKENGSGAKELAVEGYGLLQVMTTDGIIGRLTTSNHIMEVAQVLGIEAARNTIIHEIQYTMDKHGMTIDPRHVMLLGDIMTSKGEVLGITRFGISKMKDSVLMLASFEKTTDHLFDASLYSKRDVIEGVSEKIIMGIPMSIGTGLFKLVRQTEQDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2H4</accession>
    <name>A0A8H7Q2H4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphate-induced protein 1 conserved region-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_000529</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EXORDIUM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2H4"/>
    <dbReference type="OrthoDB" id="2016249at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006766">
        <property type="entry name" value="EXORDIUM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31279:SF58">
        <property type="entry name" value="PROTEIN EXORDIUM-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31279">
        <property type="entry name" value="PROTEIN EXORDIUM-LIKE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04674">
        <property type="entry name" value="Phi_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034552800" description="Phosphate-induced protein 1 conserved region-domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2184616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="30927" checksum="9EBE70415C3CA04B" modified="2022-01-19" version="1">MLLKTIATAAAFLGLAASTFAVTPTPYSGIHNKKGVAGLRPANATAPTGKASVQITYHGGPIMTGKITVYPIFYGTWSTAQKSIVNTFIGGLSASSWWNIEKTYHDNSGNTVSGPVALGTAYNDNYSQGKSLSDNSIETIVSHAISAGGLPVDTNGIYAVLTAGDVAETSGFCSQYCGWHTDATISGKDLKYLFAGRADSCVSGCVAPQNQNVSPNGDVTTDGLISVLAHEIVEAGSDPDLNAWYDASGQENADKCAWTFGTTKTASNGAAYNVVVGGKNYLIQQNWNAKTQGCALSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q313</accession>
    <name>A0A8H7Q313_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_000302</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q313"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="549"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="116"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2184393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="625" mass="68488" checksum="F3291C3D01D5A974" modified="2022-01-19" version="1">MLPGWIRQNSRAAIQTLCNHLLSLSLEECPQLLTAGGQSYIRLHNEQEEKSDRGNRDSDSELVNPRLKCAIILLYPTGRFRTSPFARGRGVFPAGKSRTLWGSGLKWTGPGHVYAVSAFAALGGLSFGLDTGMISGVLTMDNFVDYMTDGETTFTSLQSSTIVSTLLAGCFVGALISGLLCESLGRKRSILIGSLILILGVILQTAANGYIMMCVGRPIAGVGIGILSMSVPLYQSELAPKAIRGRLISLQQFAITIGIMLSFWINYGTNMHLQGTATWRVPLALQMAPAIVLAVGTMFLPYSPRWLLQQGRNEEAQQVLARLHGNGDKNHPYVLEEYNEICEQIALEKAVAIHSYVELLQGTVRRRVILGVLIQIFQQLTGINAIMYYAPSIFHATGISSGNASLLATGINGVINVLATIPAILWVDRWGRRWTLISGAIVMGVCMVTAGIVLGVCGKIVDQPGGDKTIDMSGNKAASYFSIVMIYMFVAGFAYSWGPCGWIYPAEIFPLRIRSKATSVTTAANWLFNFVVGEIVPVMLARITFGTFIFFGGCCFIMAVVVVFFFPETKGKSLEEMEFIFGERSKDFTYLREKPDPYAGYENTFNSNTYNSNTFNSGYESNYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q343</accession>
    <name>A0A8H7Q343_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycogen debranching enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q343"/>
    <dbReference type="OrthoDB" id="2591256at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034192933" description="Glycogen debranching enzyme" evidence="1">
        <location>
            <begin position="18"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="699" mass="76016" checksum="515DC93C87F9056E" modified="2022-01-19" version="1">MLISSLVATALVGAAAAQDILTTQLSFSGYTNYLYRDDVTSSQLLFTEANSTNVRTRFIAAFPAGNSGAMAYFKPSTGNTSALTLSLVDNSLKSVQYDCNQTGITGQWQLSQNAELDLAVLGSVRALRDYVEGGGILHPEMNYTLLQSSNNSVTLYRNFFNDSIAMNFTMTTDKQIQSSGNTSIALPAGTYQFTITLNETTLEGIPPATLLNQQNETIATNSSTSDSTKMVSFLSYSEKLLAGGWRFLTYFGRDTLISLRILMPILSSDTIEAALGAVLERTNITDGELCHEETIGDYASWVNMQNGQADLGSKPFYDYKMIDTNFEFLPALAYYLLGLPSGSGRATPFLSKTASLANNMTYKDLLQKNVDLVMNQSSSFAQNPTADNLIHLKDGVPVGNWRDSNPGIGYGRIPFDVNTALVPGCLRAIQKLAEASILNSTLSQTAASYANVWESKSLPLFSVPLNSTYAEQTLSDYTAYANLTSDLYMNSSASGNSTSPPSEIYALSLMEDASPVQTMNSDFSFNLMYNDNLTAELLEYSVNALRPFPEGLLTNVGLLIANPAYDSNRTNWEVFTRAAYHGTCVWGFQQSMMVAGLGRQLDLCNGSSGSSNTSTTTPIWCSNSTLVSNIKSAQCTLWDIILSNPAVEFAETWTWTFDNSTKSFVVTDPAALTPDSTEADAIQLWSFTLLAQDKPSYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3B6</accession>
    <name>A0A8H7Q3B6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cora-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3B6"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2185051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="55068" checksum="BC2496391CCCD3F8" modified="2022-01-19" version="1">MTKSKRRGNRSGRAQNGAHQNQYQALVQDEVPENSQVGARSTLDRIFGRTVSASENATNDRNIRFSPNSPHGYPFNADRSSPLADSDTNPMSTDLLIDIGPEPVVQAISNYLNQDPYSSDLDTTSRHTSVAEEDVCFPQPDIEKHQGETDYEALQDFLDEEGDILVSSPTERHNRRSSRNVFTSSPTSGGGGQSAFESNRPRYRRLSTVGGDRKFSMYGDRDKHTEFDQLDTSYRITFYSSNQTATIHARTLSEIPSNGENLIDMMKQGQYWIDILNPTDMEMKALSKIFHIHPLTTEDISMEESREKCEVFKNYIFVCFRSFDTDQYSVNYLQPIGLYIIMTRTAILTFHYRPMSHPQNVRKRIKQLKDYINVTPDWILYALLDDITDTFAPLIRAIEFEVDSIDELVLILKESEQSDMLRRIGYCRKRMMGLLRLLVSKADVVKTIVKRSEGRKADGLGPALSPEVVLYLGDVQGKLCAFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3D5</accession>
    <name>A0A8H7Q3D5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="8">Aconitase</shortName>
            <ecNumber evidence="8">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_000482</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="8">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3D5"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF2">
        <property type="entry name" value="HOMOCITRATE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="10">
        <location>
            <begin position="65"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="11">
        <location>
            <begin position="587"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="516"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2184573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="786" mass="84745" checksum="29C6DDD272A70071" modified="2022-01-19" version="1">MVTAMLSARSSLRSSSRMFSRRLATSVNPVPEKDCRTITPPYTKLTDNLAKVKRILDGRPLTLAEKILYSHLTNPEETIPVRGETYLKLSPDRVAMQDASAQMAVLQFMLSGMKTTAVPSSIHCDHLIEAFAGADKDVDSAIANNKEIFDFLESAAKKYGIAFWKPGSGIIHQIVLENYAAPGKLMLGTDSHTPNAGGLGMLAIGVGGADAVDAMANIPWELKAPNIIGVKMTGKLNPWTSPKDVILKLAGDLTVRGGTGHIIEYFGEGTETLSCTGMATICNMGAEVGATTSVFPYTQKMRAYLGATGRGAVATAADANKSFLRADEGSNYDKIIDLNLSEIEPHINGPFTPDLSTPLSKFKDLVKENGWKDDLSAGLIGSCTNSSYEDMSRSASIARQAAEAGITTKSHFLVTPGSEQIRATIERDGQVEEFEKAGAQVLANACGPCIGQWKRTDIDKSKPEENAILTSFNRNFRSRNDGNPKTMNFLAAPEIVTAMTFAGKLSFNPMTDSLKDKNGGDFQFQPPHGDDLPGQGFDAGRATYEPPSPTPTSDETVQIKVDPSSNRLQVLDAFDAWNGEEFKNLRVLVKVQGKCTTDHISAAGPWLKYKGHLQNIAENTLIGAVNADNGKVNVVTDITSGKEGTIPEVAKSYKSQNQPWLVIADHNYGEGSAREHAALQVRYLGCPLIVARSFARIHETNLKKQGVLPLTFVDENDYEKLAGGDVIETIGVKGIAPGNPVTLVVNKQGGEQLEIKAKHTMSVDQIEWFQKGSALNLIKEKVGGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3R5</accession>
    <name>A0A8H7Q3R5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_000903</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ELOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3R5"/>
    <dbReference type="OrthoDB" id="445983at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.190:FF:000001">
        <property type="entry name" value="Transcription elongation factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="79"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2184990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="119" mass="13708" checksum="A5155BE8231B52C6" modified="2022-01-19" version="1" fragment="single">GKRKSKRKPVKVLKATLDKQFNCLFCNHEKSIECKLDHQNKVGHLSCKVCDVSWQCPITYLDEAVDVYSAWIDACENVNKDRGSSRQTRGDEEDQEGEYESRPRAAAANYDDEEEDDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3S7</accession>
    <name>A0A8H7Q3S7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_000918</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3S7"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000776">
        <property type="entry name" value="Guanylate kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="9">
        <location>
            <begin position="7"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2185005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="195" mass="21847" checksum="5635545050F8E1DD" modified="2022-01-19" version="1">MMTKVAAPIFVLSGPSGSGKSTLLKKLFAEYPDTFGFSISHTTRQPRQGEENGKDYHFVSKDVMTKEVEEGKFIESATFSGNMGDPGTSIKAVQDVVEKGQVCILDIDMQGVQSVKKTELKPRYIFIQPPSLETLEQRLRGRKTENEDAILKRLAASKQEFEYAKQPNAYDRIIVNDDLNKAYAELKNAIFDESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3Y1</accession>
    <name>A0A8H7Q3Y1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_000518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3Y1"/>
    <dbReference type="OrthoDB" id="2377049at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2184609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="87" mass="10021" checksum="CF4CD3914C0FF3C7" modified="2022-01-19" version="1">MQILMTEQCHCFITEVYPTSDKSQQAAVWQPVLDRHGQISFDLTEPAAKTNDSQSSVQFLQLNRYPLSRSRHSFDSSMEPIQESDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4F0</accession>
    <name>A0A8H7Q4F0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4F0"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2185922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="211" mass="23114" checksum="C0A476D06AE9B917" modified="2022-01-19" version="1">MLLIFSIIPKVSFCSWFLLAHLLWLWLLFSLAHWLWSLLLVLAGSSALVSASLWSLLLVLAGSSALVSASVLARPLALASALGSCWLTCSGFGFCSRSPTSFGFCSWFLLAHMLWLWLLFSLAHWLWLLLLVLAGSSALVSASVLARPLALASALGSSSLTGFGFCSYFYWYTFLDLSIPLSQRPDEVSLKNDVPWHHVATCLDNQELGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4G0</accession>
    <name>A0A8H7Q4G0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_002197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4G0"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2185762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="84" mass="9500" checksum="F8E4DDDAAC29A0B7" modified="2022-01-19" version="1">MCFRSFKFGDIDNDCPRRISLSTVHRISHTMFKALFSRQAQQLSSTVSASQMGKRVVVASAVSVFAYSTVQQCRKDVLFYNKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4K2</accession>
    <name>A0A8H7Q4K2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_002198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4K2"/>
    <dbReference type="OrthoDB" id="2269179at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2185763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="986" mass="111398" checksum="FE2906E1F6A1C90B" modified="2022-01-19" version="1">MLPIQSESYIISPSISDVEEALDSALLPTLPVEAPLSIAIPETFELTIGNSVPLTSENVETYVTSHLVHYIDNSRLNLRTAMDTFLQLFSLEHSSPQRLWHFLSACKGSMLIGDTGLKEALGLVEGTASLNLQEIVPGTKFLYVRSFAVPTEKMRDIMADWEAVDYFPDEAAVWEDNISRQDTLGGALVDVRYVGQCAFPSTPEGRFAEDAASRNNGVLSHFLTSLASVCPEAYHAAKVLVLGTTFGDNVAADVVDDFERLFIGFLGYDCLLNRQQGGYYDRFDVSNEHKVIFTNLQTRIVDRWIAKRSDISQYHEMSISLRTRVQGIRAWMHDTVSIMHSINAEYVDLLWTESTPRKYQGNVITCLVAKDITVEDFLQQKDYLDRISNTGTKSRSAAKFLEAVQALVECEGHNLSQLQTESNLLNLFPFVNMFPWVGPPFLPSAIDFLGRYLQIVQPIIVVAIGEEVANVIASNMIHASGLPNGKYTEHVGIPRIMSCASEDWLNDENVDEPDSNTLSIVIPIFDPVLFLHISEAMKMLDEGVMLHPATRKRFLVTLRTRCSNKMEESGLQNALETTRGEVQAEWQRQAAIRFKPAPPNELFRMLRHHAAKDVMRVAEKAMGHPSIHAHQEEAREAWEVFMKQIAADKYYSTSIMARHQSILRIAAGKHPLAQILRQYPPADAQNDHWMWDEELAAAAYMAHGERMMRALKQARPYHFSSENQRLRALARHGTDPNFPVSLHGQRVSVAADGRMTVHWRDTESQMDETFKLYCKEAYHASNPSRTLQVTTEGIEILDEAGRLIQIHRKRRLYNCFLLKTWVKSLEGEGISVPVEEPVAGDSGARIVRSRLKYDLPVAVNDEVTPFKRFLDDTWPGEGVVFFGQADRQSEFPADSQALMIWGRLKEHLEIHSRGHPHFDFWMNLTNGVGDNRKAIQHLKKLRPVTLEREKFSFVAGQTSTGLRKRIKGKLIKFGPPLPGAERNVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4N4</accession>
    <name>A0A8H7Q4N4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_002480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4N4"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF22">
        <property type="entry name" value="GLYCOSIDASE CRH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GH16" evidence="4">
        <location>
            <begin position="20"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2186042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="239" mass="26639" checksum="1250AC1CEFE3C378" modified="2022-01-19" version="1" fragment="single">GESACKSGHWDFASMKELGDDWVQTDGPLDFSSEGLVMRLEPPTNFEQYDDDRGETLNAHLGTGFGMNATFYMQYGRVTARMRASTVKGIITNFVNMGDNGDEIDTEFVGGHPERFESNYFWGQQLIYTVNGGKHAITSPNGIADMHEYTINWTPERLEWYLDGTLVRTRLQSDTCGDNGCVYPTAPTVIQVGIWDGSRETPAWSTGPVDWSNMSEEERNGIYGVLESITVECDATNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5C8</accession>
    <name>A0A8H7Q5C8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar protein sorting-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_002621</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
        <property type="entry name" value="VPS13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="4">
        <location>
            <begin position="11"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="VPS13-like middle region" evidence="5">
        <location>
            <begin position="741"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="427"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="676"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1041"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1220"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1388"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="687"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1063"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1240"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1397"/>
            <end position="1409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2186183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1576" mass="176333" checksum="B471D4B6C7E04A70" modified="2022-01-19" version="1">MNNLEKTTKAQQSVAKKGSGWISSWWHGNSNQQASDGGEVENGLEVTEEQRQELYEAIDWDEEKATVAMSVDMPKDTMKAQIHVKLKRGSFALGSSPQKKHGDDLVTLVFDTVTADITQYIDSMKISAGLGDLRLYDGSTKGTLYKKMIGVKTRKQRSMHLTNIENQRLEEAFDKNPTDMETDPFFSVVFEKKPLDGRADNAVTVKMHHLEIIYNPAIVNEVIRFFKPPQTNMETVNALIEVAGTTLDSWKKQTRAGLEYALESHTTFDLRVDMDAPIIMVPEDCTKKDAWVLVIDAGHINVESNLAPKEAIDKVLAKQGHEYSEEDFKELESLVYDKFTIKLTDTKVLIAESVETSRKEIQNPSGGDMHVIEQIDMNFLCETCIVPKSTQLTKIKISGHLPLISINFSDQKYKTLMNVIDIIVPSNDDDDMKSSEDVHDTSNQANGPKRAMSSSMNDGQKEGNSSSYFGKPVWGASNEEPLFISDSEDSDNETLNETSDSSSRQLSTPSSFHVSSSKSVNDSEVSNEYKQTNFSLSFKIDRVKASLKEARSNETSQEMLLCDLVLEQFLLVFTQRKFDMTVDVSLKTLSVIDQMEHGREFTYLITSDEIRSDSSTSIKEKNLVTVKYRKINPNSPEYCDIDQSVDVELSALNIVVTRSSILTLYNFILSTFTTPTKEPTSRASIASDKHSRRDSVKSEQPKENSENGGGVIKVQICLESLDLILNDDGVRLATGCLSHGDVTVVVKPNTLTVDVKIANFELKDDLTSPDVDPHNLETDHSKTQLLSLEGQELATFRYATYDKDSERYPGYDQLIFLRMGSLRLNFLEHTIHQLVDYGARFAEMKVVYDSAREAAVSSAQQFQQAESLLHFDVRIRSPTLIFPSTDPKRPKDQLIARLGEVSVENTFSNKNLATEQLQRLDKSVLENSIRARVDSVDLKSEFVLKDPDTKEEHKQSLFILEEVHMDFTINIVPHTAGTLRPDTQITGHISDISMNLTESQFKFLMATSNSVTAAFTTSSENPDEVEVVNEDPLTMEAIRSVGATGDGNEPSSGALKDAVQSEMHGKRQSSTDEKDDVWTTLDMTIDFQGIKLELFKSEGSLQQEDLSEWSLASFSLEDSGFKLCTNSDSSMFLELQVASLVLNDTRADIHSEFREIMKRARLDGPQLQLRYETTPQQGITDQFLLLALDTPQIILSVDHVFELQKYLMAPFTVEEATEAQMFAESQKQREANESAEPAGGQQSVSRMKQTQTNKSQNDKQTTSTQAVLRYKINVVDPEITLLANPAAEDSEAIVLSADQVLVSQQSLLTVNVSKIGMFLCAMNNKEDIKIRFVDEFEISVSMESHTSANHNITSIIIDIQALVLRVSYLDISIITNVVNRAIELMGSSESVPSPVDDNPKDDDIQKNDDAAGTLAPPTEARSINTSGLKKRNNIEPYIVMSRETLKLSCQGIQVILIEDLHELPIIDMNLKPFTVMVSDWTKALLVDASFSLYTGFYNAKNSHWEPLIEPWSFNLKVSKALTSDSLDIEFASKRKVEIDLTHSFVEAMLNFSSTTGGQKRVHASLCWYCSFSILVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5L7</accession>
    <name>A0A8H7Q5L7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002133</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00741">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1010"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1069"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="238"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="280"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="7">
        <location>
            <begin position="1398"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="619"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="662"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="793"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1366"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1584"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="619"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="685"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="803"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2185698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1624" mass="178445" checksum="364358A2979AA117" modified="2022-01-19" version="1">MMRATTRRKVSYVVKNENDDHAHRLGVNSLALDPTAGRDAANPNVGGILYSAGRDGVIAGWDLHMPFQRASKFEIDEHEDEKSGRSWFLDQSAVQATTPQKPSSRVFSQTHTDWVNDIILCNNNEAGGLRSVHKSLNLISSLLTLGNSLVISASSDRTIKLWRPHSIAPNSIYTLGNHADYVKCLATSPVHNWVASAGFDRKVSLWDLNESRSDAILTFTTNSQQQGSSTGATGHVSEVSPKSSIYALATNAHGSIIATGSPEKVVRLWDPKSGKRITKLTGHTDNIRALLISEDGQYVLSGSSDSTIKLWSIKTSRCLATYETHTDSVWTLYSDHPQLRTFFAGSKDGLVTRTELGGSESGTAGEDECVGIFKENGGVAKIVVLDDRYIWTATSSSSVNRWLGIPPRQARASLARSTYNADIPNSAMAQLPPPELAFSGPLPESYMSNENMTLYAGSVLSIPISSYEDDIESNETLVPLRVVPESVIEGKPGLSSHLLLNNRRYVLTVDTEGQVAQWDLVECKKMKIFGNKAIEDVAQQLNSMETFSNWCSVDTKIGAITVHLDEQTCFDCEMYADEANLSPDYEIREEQRINLGKWVLRYLFEGFVTAKLLAQEEEQRNLDENDKASPIRSPVNENAYQPEPQTPNIKVASISIPVPPLPTAANGPLNNDRTSTEVNREASVHPTTGTVTAPSTAYARPDYFSGAHHDNNTPSTPYIQAPPPAAFATNTGPLSPTSGGFMGRLRNLSVKAKLGRTPSAEAKMEGSLMTSMTNADSAQTLQAQNPLHTRAASTPEHSVYNPGGTSSKQTKPLQGETNPLHPLTDAGQTKTVPVEAQIPPVPEIPSLFAPATVNEVPLIEIPSSTTVIISEESFEASSSMDLYRGTVGSTVNDADNKAPHKEAVKLTFVLRPHESSNLPELPGGANNRLLANRVLRVRKLTQYIVDRLKSEDEKAYASLQPESLELLCGDTVLGATMTLATIKQRILKTSVSAVPSLVATYLMAHEYTVLSLILFITSLLCLVVSILMFLGYKTIKKGALVIARTLSSTSRILSPIARYLSNTYVIGPIISAIIRVSFFMWFCLLLSCDVLIRSVLRQFVGYHPTGKNYSVINAMNKDLDLFDDTIPRTSNLESGEKFRQRKRATDTKDKHLSDLLRRPRYSLPLAYTLGVASRLAYEDVDVIKYELKRAGFDVENTFRPVAYKNICAFIAEKDDDILLVFRGTNPLNMANYMTNINMSKAEVNSPYMGYMGKVHKGFWEAMGDPLMKRKPSNAQNDDKPSSSTVNIELSGTSVSRTIWTAVKAILQIIKFLTFNISHHVRDPVDSRWLGGDVDLRSQNLFVQAESWIMGLIERDLVDDLAVVPDAGDTDSSSTDEQAKKSKRRSVDTATNINRRSSKARKSTKRLFITGHSLGGALSTIFLAKMLQSNSEMLQIFAGLYTFGHPKIADNDFAKTFSPRMSSKIFHHAYNNDIVTRIPSHDNYSSPPGTLVFIDSGYNIALYPPNPLTNEPVPIRPISFLHLSGLLNRHIIARLVSDSLVRIVLRIVFPFFVNDHFPSDYCEALRKGKINWVVIGEGGISAGDETDEGIRMTPTKQSSGQKGSRRLNVMVGSASKRGSWPAAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6U7</accession>
    <name>A0A8H7Q6U7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Intermembrane lipid transfer protein VPS13-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6U7"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="2">
        <location>
            <begin position="166"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2186184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="296" mass="32964" checksum="9811F05DD79B9568" modified="2022-01-19" version="1" fragment="single">SGVAELFYEPYQGVIMSDRPQDLGIGVARGVGGFFKKSVFGFSDSFSKVTGSIGKGLAVATMDRKFQDRRRANMTRNRPKHAMYGVTQGVNQFGTSVASGVAGLVKRPVEGANEEGVTGFVTGFGKGLVGVVTKPVVGMFDLANNVSQGVRNTTTIFDVNDIDRFRLPRYIASDGILRPYSQREALGQSWLKDLQNGKFFNEVYVSHCMLTTNELAAMLTNSRIMVINARKSTLEWQEHFSDIDTIQYRETGIVIMLRNTRSERFIPIPEITTCKWFFSKIEDAVAQWGEQQNLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U6S7</accession>
    <name>A0A8H7U6S7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">INT43_008166</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U6S7"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000026">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000064">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000010">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="923"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="962"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1005"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1042"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1070"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1117"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="96"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="21">
        <location>
            <begin position="190"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="23">
        <location>
            <begin position="891"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="16">
        <location>
            <position position="475"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="569"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="610"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="633"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="666"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="746"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="747"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="748"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="839"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="845"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="865"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="868"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="869"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="869"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="24">
        <location>
            <position position="1212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAG2171786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1212" mass="137052" checksum="602E764B6D80126C" modified="2022-01-19" version="1" fragment="single">SLYEDSSIPLDDDDNLQLLDHQGPIAGSRYNRQQPPSTPPTPGSLSGGIPLRSSQRPSSRPSPRGGRRQSIRGRINELLGRSPRVAPGQENEARTIYVNNTELNDQQNYLHNRIFTGKYTFVTFLPKFLYEEFSKYANLFFLFISGIQQVPGISPTSRWTTLVPLLIVLLITAVKEVIEDWGVHRSDAELNARPCKVLEGSQFVEKEWRDIKVGDIVRIDGGGHFPADLVLLSSSEPEGLCYIETSNLDGEVNLKIKQALPQTAKLVTPVDISQLQGTIKSEQPNNRLYNYDGTINLSVDEVGRARDFALDPTQLLLRGAQLRNTSWIYGIVVFTGHETKLMLNSSKKPSKVSNVTRITNRNILYLFVILVVMSIACSIGGLAITITKGSDLAYLALNNVSRASEFGYDILTFLILFNSFIPISLMVTMELVKYIQSYLIDADLDMYYEPTNTAATARSSSLIEELGQIQFVFSDKTGTLTCNEMQFRQSSIAGLSYADKVESDRQASDGVDDPNLQYTFAQLQEHLKSHSTANVINEFLTLLAVCHTVIPEKQEDSEEIVYQASSPDEGALVKGASTLGYTFHTRRPNSINCKIRGRDMEFQILNVCEFNSTRKRMSALVRGPDGKIKLYCKGADTVILERLAENNPFVEPTLLHLEEYATEGLRTLCVAMREIPEDEYARWSQIYDKAATTLVNRSEELDRAAEMIEQDMFLLGATAIEDKLQDGVPDTIHTLQEAGIKVWVLTGDRQETAINIGYSCKLLNEEMSLIVCNEENHWDTKNYLEAKLKEINDVRSRGEDLEPLALVIDGRALTFALEKDIEKALFDLAVLCKAVVCCRVSPLQKALVVKLVKKYTPAILLAIGDGANDVSMIQAAHVGIGISGVEGLQAARSADFAISQFRYLKKLLLVHGAWSYHRLSKMIFYYFYKNVALYLTQFWYAFYNGFSGSTLYESWTMSCFNVIFTFLPPLAIGIFDQFVSARMLDKYPQLYILGQQNEFFNQKKFWGWFANAIFHSLILFFTGVGCFRNDGVFMNGTNGGQWWVGTVVFTAVLGCILWKGALITDIWTKYTFIAIPGSMALWFLYLPIVAYIGPAISSSVFPEYTGIVPQVWGNVNFWLYLILVPFLCNLRDFAWKFAKRMYRPMPYHFVQEIQKFNLPDYRPRMDRFRQAVNKVRRIQRLKRNRGYAFSQTDSDQTKIIRVYDTTQQKPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U6W8</accession>
    <name>A0A8H7U6W8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_004762</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U6W8"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034228482" description="B30.2/SPRY domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="8">
        <location>
            <begin position="91"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2172221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="371" mass="41059" checksum="B2D2836749A63003" modified="2022-01-19" version="1">MSLRATLGLLATCIPLVLAGGAAHTQAFSSVWPWIFLVGIIVLFSVCITLLCCTRQRIALPLDDEFTAEFDEWPLEREEDVATLSEDAALSYTRAKAWQQQHPPDCIPTDITLSQYMSIQEKGIQAYEFEFQLESNSFVAGRTEIQFYHGESCVQTNLPLPRNQEVYYWEAKMYEMPENTVISVGVATKPYPNWRLPGWNRYSVGYFSDSGRKFTHSIFNSRPCSLPFKEGDVIGVGYRHRTGSVFFTRNGRKVDDISSNLNWNLFPTIGANGPCQVHVNLGQMGFVFVEANVKKWGLAPIQGTMAPPPAYGLEGGSILLASSSRGGDTDASTSDHSNPDQVAPGSHQAFSASSSRGLQPPPYSSFDVEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7R3</accession>
    <name>A0A8H7U7R3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7R3"/>
    <dbReference type="OrthoDB" id="3170343at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="123" mass="12828" checksum="B8FAD934A64B2DF4" modified="2022-01-19" version="1">MNPNTQHHDHVKRDAVLGAGAGALGGHEAGHGHTGRDAIIGAGVGGIGEHELKKHDKHHPVAGGNAVSREEARHNQKKAEERAHGHVPVGDKIKGTVKEVEGKLTGNQAKVAEGKALKDDRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7Y0</accession>
    <name>A0A8H7U7Y0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7Y0"/>
    <dbReference type="OrthoDB" id="2349787at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF72">
        <property type="entry name" value="IM:7136021-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="2"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="563" mass="63017" checksum="8DBBA3B7AD9E1C3B" modified="2022-01-19" version="1">MTNLPPEIIAHVLSFASKSTLRACMSTSRQCHSLAQRILYANLELPIEAFKTLVAAVSSSQNSDIYLGSLVKSFGLYNANTDDDITSTQIATLLPTFSQLEELSLPYPIWERFPDLPNVLGSCKKLHTITCIPQAIQVLSSLYGRQLTSLTVIGRYTFLDTVTEIPSLFPNLVHLSISFGIEILQIQFLENMAIHCHNLDSLELIGCSVFPVQGDQQTIVKASSVSKVTISFANLDPTWLAHIGERYPNVRKLSVTAMGGRDRLPYSASEWEVGFVQVARHCALLSELHCQSLQTDDDFYTTRIFFDTFSKTADPNHGLKHLTLFFAQSFMDADLLGAAMCAGKTLTNLELKRCPSITMSGFKAAMDQCSALTELNLSVREFSPSILLICCPSIKSLKLEASTIIHNSLDSSEKYQQIKLRKLNLTRVKNANVFIDAISPYADMLCEISIFDGSRREPKDYRIHLPKNIIHNLDIIWMLGSRVEERDPFYFKLSQTSLSGGQPTVHWCIRSGEPQGRFHMVAPETVPENASYFDISFLSLRRLAFNGAITNFDHENADERIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U872</accession>
    <name>A0A8H7U872_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U872"/>
    <dbReference type="OrthoDB" id="2391735at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="309" mass="34323" checksum="FD2644AA10881414" modified="2022-01-19" version="1">MACNMFRRLWSPPLGIQPTCLNNAGRHAGVISRPIAYRPSLLVLARPIHQPALRPGALSSRLGLSNHFNRVPASLPHQYLHNRSFSLFKPPKIFRTFTKWQRRLSFISAFGGGILLTIFIGPILLVAVGGAAAVFWWRYWRHMRSGSVGESSVNRENLVQSPLSSIGSLFSNSPAHLTEGLQTQAIERIKDDLNDQSSDIGRYLATQSPNQLKFSDVYAESTSKSTAIHNGRREDKSYISIEFSLTAGEGHGTKGIAQARGTTDGEHVNLERLSVYWPQWNRETVLSGETKNGTNINRGSVIEGEFRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8P9</accession>
    <name>A0A8H7U8P9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bola-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8P9"/>
    <dbReference type="OrthoDB" id="203381at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052275">
        <property type="entry name" value="Mt_Fe-S_assembly_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188:SF1">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2172387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12330" checksum="5EE751A25F922FAC" modified="2022-01-19" version="1">MSLPTFARLCSRTFVNNGSHASKSVGSLQATRLYSSESETASLTEGERHIYNKLTNELTPLRLQVADVSGGCGSMYAINIASAQFKGMSVVKQHRKINEILKEEIKEMHGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8T0</accession>
    <name>A0A8H7U8T0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc-ribbon 15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_005610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8T0"/>
    <dbReference type="OrthoDB" id="5545479at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139:SF1">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2176376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8737" checksum="9DFAA77CE6EC6F40" modified="2022-01-19" version="1">MFFCFTFGLEPWKRRQKDKVYNCPRCSAQTVYYEKINDCFTFCFIPIIPCGSTKSLYECYTCGWVNVQAPHQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9R6</accession>
    <name>A0A8H7U9R6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_005997</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9R6"/>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21150">
        <property type="entry name" value="PUA_NSun6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF34">
        <property type="entry name" value="TRNA (CYTOSINE(72)-C(5))-METHYLTRANSFERASE NSUN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="6">
        <location>
            <begin position="156"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2174935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="457" mass="50918" checksum="2EF92FEC1083B51E" modified="2022-01-19" version="1">MSPLPPLEVPSEVAAFFLNVYTETHWETLRQQLACPPTTTYFRVIVPLSYRPDLDFTSAVRERRNEILPELQSKIDKHCISRNWDTGQYKVLCHSMLDDVLYLPVLENFNIEKPEKEVMIDTSAGTAVLRGADIFAPGILAAESDTHVDNTVAIMVDMDKKCLRGRSKRFDGRKIHVGNGILKQSRQAIFSKKPSELSGDGVIMTDPIYKTCGIPQGMNDQLFLQNITSTLASALLEVGMDHKVLDMCASPGGKSIHIASMCRGFGCVIALDKNKYKIDRILKNAQIYQVEKKVRAYICDSTNLEGDSKPDEFKGLPGQGLASESFDRIMLDPPCTGLGQRPVFGTTSEVQKVNSFRTAQPAYQKRLMTQAVRLLKVGGIMVYSTCTLNPHENEEVIADCLSRYPNMQLIDPEVKIGGPGLLNYGLNAEDCERVQRFDPTTHPETVGFFIAKLCRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9T2</accession>
    <name>A0A8H7U9T2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome c oxidase subunit 4, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cytochrome c oxidase polypeptide IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_005097</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 5B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9T2"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00924">
        <property type="entry name" value="Cyt_c_Oxidase_Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.11.10:FF:000003">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.11.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002124">
        <property type="entry name" value="Cyt_c_oxidase_su5b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036972">
        <property type="entry name" value="Cyt_c_oxidase_su5b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01215">
        <property type="entry name" value="COX5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57802">
        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51359">
        <property type="entry name" value="COX5B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 14" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="17">
        <location>
            <begin position="56"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="287"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="659"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="667"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="683"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="686"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602124-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2173677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="704" mass="77506" checksum="9D9D2AB0EE0D81C6" modified="2022-01-19" version="1">MVSSEYIDSVDHQRGENTAEHIDHHQADYQHREHEHSELEALDDRGTKLHWRQIRLLMIASIGFFMDAYDIFIINLITPMLGYVYYANSTPPNQAITMPFLQFGFAADINFDVCNDRYQLIGQLAFGYIGDRFGRKKIYGVELIIITIATIFCATSASAEAGLSAIAFLGFWRLILGIGIGGDYPLSATITSEWAASGRRGQLIATIFSMQGFGNVAASLVTIIVLACFKVPVQANVVNLDYVWRICIGLGAIPCAATIYARLSLPETPRYSVDVLGDKEGARKSLEKNKWVQENDKENSPYQRNSVAPENNEKVEERNEIVSDSTEHNVANEPVVKLHNRDFRAYFSKWANLKVLLGVSLSWFLMDIAFYGTNLNQTIILSQIGFAPKGLDPWDTLFREALGNLILSVLGALPGYIGAAWNPIHSVNVALFIVLFAIIQFFFNFGPNATTFILPVEVFPTRHRSKAHGIAAASGKAGAIIATFGFNALADVGGPPGAQTFLPNVLIIFGVIMLLGMIPTMWVPEMTQATGQRLLSLVFSKQHFAEYLFINIMLALRRAAVRAIATPRPAIVRPFSVLGARLSGSVSKHDADALIGPGAAPGTVPSDIDQATGLERLELLAKLEGKELFDMEPLNMTHLGTKQNPIVVKSQDPTRFVGCTGYPAESHDTIWLTVDKSHDFDRCPECGSVFKLDFQGSEDAHGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UB13</accession>
    <name>A0A8H7UB13_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_001803</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAR2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UB13"/>
    <dbReference type="OrthoDB" id="1922221at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13778">
        <property type="entry name" value="Aar2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13777">
        <property type="entry name" value="Aar2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.550">
        <property type="entry name" value="Aar2, C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007946">
        <property type="entry name" value="AAR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033648">
        <property type="entry name" value="AAR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038514">
        <property type="entry name" value="AAR2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033647">
        <property type="entry name" value="Aar2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689">
        <property type="entry name" value="A1 CISTRON SPLICING FACTOR AAR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689:SF4">
        <property type="entry name" value="PROTEIN AAR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05282">
        <property type="entry name" value="AAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20981">
        <property type="entry name" value="AAR2_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20669">
        <property type="entry name" value="Exo70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="5">
        <location>
            <begin position="248"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="AAR2 N-terminal" evidence="7">
        <location>
            <begin position="625"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="AAR2 C-terminal" evidence="6">
        <location>
            <begin position="755"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="916"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="924"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2178956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="943" mass="107884" checksum="C57E0EAD12E61E2F" modified="2022-01-19" version="1">MNTFSPNANTRGGNQARLLEDEADLEYMKGNLQKMDDLTKRMSGMLDSFDGRLVKLEASILPIHKSTQNLTQLASNIDATLKSTDSIVKCMDLPSKEEALILKGPDENNTLPYLQSLARLRDALEILSAAKLKATDKVTNQLKQLLKAGTLHLETLFRKWLSSASVPLDARSHNTEPPSMDPAQIKRLSQLSTYLSTSESELGYAVDFTKPYIEIRSAYLSKSMHNLSQIAAADRQTGVYERGAAEFLRYMTFLTKMFMFEYDLATRLLSNPVHRTAALKGTFASALTDFIAAGKAINAHVRRSSYQDFFMILDVLERYESECNAVLEKILPRKEMDTILELMAALKGTALRSIYEFMEDVKGRKDPANPNLSNDGTVHELTSNTLSHLKRLWGWNDIVEPVLLILGNDGWNNPITPAAEQQPLTLKSTPDGRSLIKNFFVDVLDQLNNTLQVKSKAYRKPALAVIFLLNNYNHVLRQIRSPPLNAIFDEGREARFGKLVRRQMDAYQETWKPCIENLMDVTYVRGGAIKQSLGNNEKQQIKDKFRNFNVAFEEIWRTQKTYAIPDSELRFAIIRDVKNVLLPMYSRFLEKYQGTDFTKNTAKYIRWDKDQLDRMLNQLFEPAASTSKEGLSGMRTGFFRFFEAGEVVVKEWDNQTEALRDDSELDNTQVERYSRDIKSFDKNLGAYPLDPPTNWQRWLNLTNYIKSSLLRRVFPNNGFISHMPAKSENSLPGLLEELDRRMGRDVIEKEEGVEFTKFDLKQSFPTGASGQEVTKWSLDKSWLTKSLLTNAYHSDYHYLLGEFQLAFVATLLGQNFSSFHQWKKLMQLLSSCQELIEESPQLFSDFLDVLTKQMKECPQAFFYEILSEDNFVSQVLKTLARNIPASNSKLRQQYLALHEVLKKEFNWEIPGLSSSLKNKNETPYSDEEDEEEEGEYAPAIVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UB40</accession>
    <name>A0A8H7UB40_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_001895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UB40"/>
    <dbReference type="OrthoDB" id="2260257at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034508776" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="26"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2179046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="205" mass="19679" checksum="C25AB3AE3348B2C7" modified="2022-01-19" version="1">MYKLTASLALLALAQAAMAAISITNPVAGTTWKQGSKATISWTATGDDASGDVQITLMQGAATQLQTVESISDSVKGAASGKYTWTVPKDTPNGADYTVAFGSAPNFYYSHYFTIGKAAANASASASGSGAAATASVPMSTAAAMSTAAAPSGASASASGSSNSSMASASGAPSASPSTSSGARSAAAAMAVPAVAAAAVIAALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBL2</accession>
    <name>A0A8H7UBL2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_007569</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBL2"/>
    <dbReference type="OrthoDB" id="10018316at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15760">
        <property type="entry name" value="FYVE_scVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164:SF30">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="95"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="166"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2176915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="232" mass="26058" checksum="70B7D9DE840EC38A" modified="2022-01-19" version="1">MDVYALTRKQRPAHLTMGSTQPNDNQHHAHPLSQPLQRDNHRRGGSTNQIDVEAQLMASRALRRSSILSTLAIGPPSRDHWKPDSEASHCAYPGCTTRFSLFERRHHCRKCGDIFCAAHCSNYFRLDQSISFNPHGDLVRGCDTCARQQQRWLSIMRRASLTAAANKAQDGAIEPNDDQRSKPNTEGDASNRPRIMTNLPPQDMEGISELGRDGKLGVRIFVKCEAWLMTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBL6</accession>
    <name>A0A8H7UBL6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit D domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_001244</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBL6"/>
    <dbReference type="OrthoDB" id="1009at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.645.10:FF:000005">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="6">
        <location>
            <begin position="191"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2175597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="461" mass="52159" checksum="51FF1995DAF09F3D" modified="2022-01-19" version="1">MSFTRVFARRLGAVTPKLAFSKSAASMARSNLQWQGWRGMAVAAERAADATPVTTIQEEPYTAFGDVKDEDESKMRNFTINFGPQHPAAHGVLRLILELNGEEIVRSDPHIGLLHRGTEKLIEYKTYLQALPYFDRLDYVSMMTNEQAYSLAVEKLLNIEVPERAKYIRTMFGEITRILNHIMAVMTHAMDVGALTPFLWMFEEREKLMEFYERVSGARLHSAYVRPAGVALDLPMGLLDDIHAWSEQFGDRIDEVEEVLTGNRIWKTRTIGVGVVTAQQALDWGFSGVMVRGSGIKWDLRKVQPYDAYDKVEFDVPVGQNGDCYDRYLCRVEEMRQSLRIINQCVNQIPAGPIKVDDWKIAPPPRANMKESMEALIHHFKLYSEGYSVPAGETYTVIEAPKGEFGVYLVSDGSNKPYRCKIKAPGFVHLQGSDFMARGHMLPDMVTIIGTMDIVFGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBY5</accession>
    <name>A0A8H7UBY5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ammonium-dependent carbamoyl phosphate synthetase</fullName>
            <ecNumber evidence="10">6.3.4.16</ecNumber>
            <ecNumber evidence="3">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Arginine-specific carbamoyl phosphate synthetase, ammonia chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">INT43_004316</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="10"/>
    <dbReference type="EC" id="6.3.5.5" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBY5"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="223"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="768"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="18">
        <location>
            <begin position="1032"/>
            <end position="1184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG2174293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1184" mass="130223" checksum="AA8860631BA1BBC5" modified="2022-01-19" version="1">MYKQVYSRVHRGLNTPAARLSARALNTSSRVSSTNKPTQCAGQSFVARAQAFQFNPIKQNRAAFFSTSSRVSSAVLPNETQNRDGAAALVSEEILDNVPLVDVKKVLVVGSGGLSIGQAGSQAIKALRESGVETVLINPNIATIQTSHSLADSVYFLPVTPEYLVHILERERPDGILLTFGGQTALNCGIQLDRMGVLERLNIKVLGTPIKTLLTSEDRDLFAQALKEIDIPCAQSTAVETVDDALNAASEIGYPVIVRSAFSLGGLGSGFASSEQELRSLATKSLSLSSQILVEKSMKGWKEVEYEVVRDAANNCITVCNMENFDPLGIHTGDSIVVAPSQTLSDEEYHMLRTAAIKIIRHLGVVGECNVQYALNPESLEYMVIEVNARLSRSSALASKATGYPLAFIAAKIALGHTLPSLRNAVTKTTTACFEPSLDYIVTKIPRWDLSKFQYVDRHVGSSMKSVGEVMAIGRTFEESLQKAIRQVDPNWQGFQQLPAKFDDVDDVLSDPTDRRIFALGEVMLSEDSAVREKYNVDHLHNLTKIDKWFLHKLQNIANVNNELRSVKNGASALPQSLLHLAKKTGFSDTQIAKLTGTNELAVRNLRKEAGITPFVKRIDTLAAEFPAHTNYLYTTYNATSNDISFNDQGTIVLGSGVYRIGSSVEFDWCGVSCIRALRDLGEKTVMINYNPETVSTDFDECDRLYFEELSFERVMDIYEKETAKGVVVSVGGQLPQNIALKLHENNANVLGTSPKMIDNAEDRFQFSQMLDKINVDQPAWKELTSVDEAYKFADNVGYPVLVRPSYVLSGAAMNVAYTPEALKKNLSEAADVSPLHPVVITKFIQGAKEIDVDAVAHDGKVLIHAISEHVEEAGVHSGDATLVLPSRDITSQTKDRLKEITDKVAKAFEITGPFNMQIIQQELPNQESALKVIECNLRASRSFPFVSKVLGKNFIDIATKALANKDVPEPVDLMSKDYDYQAIKVPQFSWTRLQGADPFLGVEMASTGEVACFGKDKNEAYWSSIQSTQNFRIPKRGTGVLIGGDEVTNKEDYEYIAKKLHNELGHEIFTPTAADTQFLNSVGVPSKTLPIAETSEDKRGLQELFKSNDIDFVFHLAKLRPSDRLNEGYVCRRAAVDFGLPLMNDAKVGRLFVDACVQKRVDTPTGEIPSEVVSWAEYTGVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBZ0</accession>
    <name>A0A8H7UBZ0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_004331</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBZ0"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="642"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Cux N-terminal" evidence="14">
        <location>
            <begin position="5"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="13">
        <location>
            <begin position="423"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="561"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="32"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="122"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="252"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="413"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="505"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="561"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2174308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="699" mass="80492" checksum="5CE824E3BA5A61DE" modified="2022-01-19" version="1">MTAEVDTFSSAINFWKNANLGSLQTELDQQGLEIIEKQKDGLISRKKLAEQTRDFKKLGDDEKLQQFKALLKGYQTEIDSLTKRTKYSENSFLSIYKLLADAPDPTPFLETAVEQGTKLIDQDTLRSENASLRQQLEEANKHLSVVKESASEASTWKHKYEELEAKYEKNINETVAKKEQENKSQLNEKIRFYKEREHDLQRQLSHAHDQLTQLKHSHDDSQAKLIDHSSKYGAYEEVVAKLAELDIVVMDLERSNAKVVEAQSKNEMLKEEIANLKNQKSKNHSDDYQEPQRQAEMTRLITDLDNYKEMLQKTEARLGKKVKDLTTQLSTKSAEIENIRESLKKYEDYDEIKRELEIMKYVEFSTGDDDDEYQFDAEGVLKTNPDNKDSLEMRLITKNKKLENTNTAIKSSLADSQKALEIANSELESVRKTLVEQKSLIEKLEEDVYRIDQSKSEVGSGALTSSSSAVNLNFLSQPAADSPRASFDASSREDKSILPIITGQRDRFRQRNAQLEEELKKQQSVMDDLRGEVDMLKQDNLKLYEKLKFVHVWREERSNGRQPSASVVSMSDTSGSPYRRVGEGTSNGRSDDPADKYGKLYEENMNPFTQFHRREENRRYHALNPAEKMTLSLTRLFVSNKWSRYFFIIYSLLLHMLVMVTLYQLSLWEECRHDHETPNFANPMGINDNGEGMAGGAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCW0</accession>
    <name>A0A8H7UCW0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sterol 24-C-methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Delta(24)-sterol C-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_007571</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of methyl groups from S-adenosyl-methionine to the C-24 of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Steroid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCW0"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="6" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="7">
        <location>
            <begin position="79"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2176917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="371" mass="42132" checksum="A3F20E00F617D48A" modified="2022-01-19" version="1">MSVTVNNPSEEIQLMRKLHGNLVLEESGFLKKVTQKDSDLNKRAAETYYSNWQDKKNIENNEEHVENRREHAQVMTNAFYDLVTDFYEYGWGQSFHFAKLYKGDTFEENIKRHEAFLALKLALKKGDKVLDVGCGVGGPLREVVKASGYAHVTGINNNSYQIERCQAYSIKYGLTPYTDFVKGDFTQMPIENQIFDGVFSVEATVHAPKLEMVYAEIFRVLKPGGRFACYEWCTTPQYDEKDLAQKKVIHAIEEGNSISKLYTTQQCLAALKTVGFNVLEEGDAAIIDDATNPWYNTLKAPEGIRGMLRSPWGRFYTHSFLTFFSKFGIVPPGVLETSQLLNDAADYLVKGGEMNIFTPMYFFVAEKPLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UD25</accession>
    <name>A0A8H7UD25_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_001110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UD25"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0697">Rotamase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2175463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="358" mass="40643" checksum="82FF3D8D0A78F2EB" modified="2022-01-19" version="1">MSYTKPQKRIVTKEELEEFQHSTAYEDFIGYIERLNDSVKGCRIDSEIKTSPSVNKVIDLLEHLIKLRARIPPVENSLSRFGNPAFVTFYDKAAENLPELLKPIVEEDAILEVSTYLIESFGSRRRIDYGTGHEANFIAFLLCLEKLGVLTAEDLKATVLRIFVKYMDLMRDLQFSYWLEPAGSHGVWGLDDYHFLPFMFGSAQLIDHKYIRPKSIHDPDIIEQFSKSYMYLGCIAFINSVKNTATLRWHSPMLDDISAAKSWAKVNGGMIKMYKAEVMNKLPIMQHFMFGNLIHFEGGSVVEDNDDGCGHHHHQGVDEDVKDVYAMGQERPDCCGIPIPSAIAAAAAGQQRRPIPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UD87</accession>
    <name>A0A8H7UD87_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_007949</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UD87"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF3">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="565"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="597"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2177292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="681" mass="74000" checksum="01E989CA47D98B78" modified="2022-01-19" version="1">MATHYDEKVEEYDPSLTEDISDDHKQVIPEEEVSHPEHFEEHQFTWRSAIVGSLLGCVIAASNTYLGLKIGWTFGASLFGAIFSFAILKPLSRALPPRWGGGYFGPKENCSAQSAATTAGGLSAGFVAGIPAMYKLGLMTTPEQDAGTLVVWTMCAAFYGLFFAVPLRQHFVVNQDLVFPTPRATANTIMSLHNSVDGEGQAMAKAKWMGIWFAISFFWVLIAYWVPFFDTIHILWWIGHDANYPAMMNADAGWSWSFTWDMPFFGAGLMTPGSTVWAFFIGELIPFGIAGPILVSKGFLIKAYGFTPKGPTAQSFFLWPGIALMVFASFTEVLVRYKSLWNGVKQAGVEMKKIYRKVFRKSSPDASEDIVADDQYNTDELVPMTWWMGGTLLSSIMTCAVMGKLFGMAVYQTILAIVLAFILSFVGLQAAGETDINPTGAIGKVTQLIFAPIPAGNMYQLQKNNLSAGNISASAASQAVDMVGDLKTGQLVGASPRSQFYAQLVASFFAIGISVGLFILFAKAYPCVISQNDDEKCQFGLVAVTAWKNVTLLLTGGESIPKESLILTGVCAGLGIIFPAVKFFFLPEKYHRFWPSISAVGVGFINTGPEVPIAMVIGWTAGKIWKRIRRTDYDNFMYAVAGGMIAGQGISAILKAVLTIGGVPQWSTAISCIDQDAANCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UE52</accession>
    <name>A0A8H7UE52_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_005357</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UE52"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071889">
        <property type="term" value="F:14-3-3 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000001">
        <property type="entry name" value="TBC1 domain family member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000004">
        <property type="entry name" value="TBC1 domain family, member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="GCN5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="155"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="524"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2176124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="828" mass="93399" checksum="4305359AABE094C4" modified="2022-01-19" version="1">MSNIVVKVYPGPQEFLDALLPQLEENELENCQLIAKSRMWARDKVTDGYYAAVLDGEQFKYALCWAPRNLMWLSYSPPDGSDKDYQVLLAKHLAQVEHAVTEVYGFQGCEPGAATFKNAYNEAANQKFKVHRPMCTYRLTAVRYPEQSRELLEKGTLRLATEDDNVNLFAEWYRDYCGLCALSTPSPEECVKAMTNLMSVEMLYIWVLEEKPVSMTFKMRPLKYGTSVAGVYTPPDSRRRGYATAMMAAFCAKLLETFQFVTLHADANNPTSNHIYQDVGFVKYRDTNDYNRLENIADHVSDAQLPPSSVHVVKAGSTPGGVPSKVVGAQYSYATLITSKSSKKEAQALATVPSYIGQPGTVSSGSKSSPATGSSKPYAGRSAPLPPVKNFNAFMKQTNEEWDDALDDVNSTDMPELDLQPEVPQFQKRVHPKTSRPDTPTSAPIETKPSPEIVTKEQPPASLRKRNSNGLKDNIPGLLTDPSNLLQSCIQDLNKVDSKYTRFKNILSCSNVDLAALRELSWSGIPPDFRPMAWQILLGYLPCNSDRRVATLARKRKEYEDGMSAAYARGTAGLDQTLWHQIHIDIPRTNPGIPLYQSEATQMVANSLLVFICLERILYLWSIRHPASGYVQGINDLVTPFFHVFLSMYIDDDAENYNVGLLPKEVLSVIEADSFWCLSKLLDGIQDNYTFAQPGIQRQLATLKELTCRIDAPLAMHLQNEGIEFIQFAFRWINCLLMREISLRNTVRMWDTYLAEGSEGFSEFHVYVCASFLATWSVQLKQMDFQDIMIFLQQVPTSNWTEKDIELLLSQAYMWKSLFHNAPNHLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEM7</accession>
    <name>A0A8H7UEM7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEM7"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF283">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="34978" checksum="0B865D2E070C117C" modified="2022-01-19" version="1">MSNNFGFEATGDEVAEFYAGEIKGKTIIITGCTWGGLGAETARVLVKHDPKVIVVAGRKQEVLDDTVQNIKKEMPDAHIRTLVLDLGSFKSIRRAAEEVNHYSENVDVLINNAAVVYPKYQTTEDGLEAQFGVAHIGHFLFTNLILSRMLATGSPRVVNVSSGGHALASIFFDDPSFKNGETYDKHLAYGQSKTANVMFAKELTKRYKSKGLTAYSLQPGVIKTNLSRNSSLGEKPRGPVLNAWGEEVVIPVDKWKTLNQGVATHITAAFDANIKDQSGSYLEDSQIANDHVKPHANSEADAERLWILSERLVGQKFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEP7</accession>
    <name>A0A8H7UEP7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_007815</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NSE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEP7"/>
    <dbReference type="OrthoDB" id="26899at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16651">
        <property type="entry name" value="SPL-RING_NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026846">
        <property type="entry name" value="Nse2(Mms21)"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330:SF1">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="11">
        <location>
            <begin position="165"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2177158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="264" mass="29889" checksum="44B906660DA2F9D5" modified="2022-01-19" version="1">MASTSSTRSAGIEPAANLMSEFELTVESTRKITSLLRNNEKISQNILLGMQLATDAACDAEEHQLQSEVSNLEGDLQKCIDIEAQFAGQEESLKQLNDSILEGQRITNMVEYCNAHRKQTEQQTASQRSKRPKYKEHDAYADFKQRIWDVNHKDEEMPSSGDEDGDDDIVIGRAKVSLRCPLTTVLFEDPVTSKLCKHSFSKHAIMQLLRQHGEPMPCPIPGCDQRISKDTLYKNHLLAQKVQRVKQLEAQKSKDNTEYHEVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEV4</accession>
    <name>A0A8H7UEV4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEV4"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034695370" evidence="1">
        <location>
            <begin position="20"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="191" mass="19707" checksum="8D4A723835EF0C33" modified="2022-01-19" version="1">MKFAPFIGLLLVASSAVQARAVHKREVGEKAADVAQSITNLSEEFMALSKSAQKVMKGDLTASGTAFSQAAQLPATLAKILADCQAVQGIFSPAEAEAIFVPVRTLLPAIKKTFTGFAPKPASGFGFGIPAMPAGGSPAGQILSAIQDAFPPITSCLQAHSLPADQMTGKGYIKQANDIISDASAAMNMQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEZ5</accession>
    <name>A0A8H7UEZ5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_006265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEZ5"/>
    <dbReference type="OrthoDB" id="1915122at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040153">
        <property type="entry name" value="Rcf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018:SF3">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="6">
        <location>
            <begin position="88"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2183261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="203" mass="22133" checksum="5A89959755F35BF2" modified="2022-01-19" version="1">MSASQLSKEQQEKLSHVSFMGGVKGAAFGLGLGLISTVVAQKRSPNFQALTTPVKSIMAGSATVAGYLFGSERGARKYENAEYGYLDEEELRRLAHEEGGQSVSAKDGIIHYLNANRWSIIAGSWAVSMVGALTYSFSNRYLSTQQKIVQARMYAQAVTIAVLMASAGLSVYAKDDEKEQHDEPDAQLRAVLELPHKEKSKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFF1</accession>
    <name>A0A8H7UFF1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFF1"/>
    <dbReference type="OrthoDB" id="2251794at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034971298" evidence="1">
        <location>
            <begin position="22"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="129" mass="13031" checksum="4842EB64ADF4935C" modified="2022-01-19" version="1">MKLSVSIVTLLGVFALSGVQASIGDLCYAPGSVGKEGEWPGDNNETQGVCLTTSSCSSLGGKSYAGHCPGAASIQCCVSPKCGPAGRYKVTGFCANDSGCANFYGYDGDSYSGLCPGPSNYKCCVPNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGV4</accession>
    <name>A0A8H7UGV4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBM21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGV4"/>
    <dbReference type="OrthoDB" id="1881at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF36">
        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="140"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2181207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="426" mass="47684" checksum="504B48461C4C49E1" modified="2022-01-19" version="1">MPYTASTTTTVQPHRRVSLSKPSSFDTQRDSDFDVPPEPIPNVRLQLATDDFPLTKPVLTTATLAPKSGLRPVLKHRAHTAPVNALPKYVRFDQKLEHVRLFLKAQTPSSVQNDPVLDLEEEDVNTINLQYPNWQNKIQSSAGDMVSIESLALANDQKSMIGKCKVHNVAFNKQVTIRYTFNYWQDVEETQAAYRESIGRDSAYDRFMFNIPLNDRMTTSKHETMYFCLKYTVNAGEFWDNNDGLNYQVEIHRGSPPKPIKTADDDFAVPVKFGNKTNLSSSPTYDFPAKPLQKKPLGSRYDFGASLSAAASNKRHTSRPNVKPPPITRVQSFPSYFSPAVDEQPTPSPQRTLSISYNPGFSTLSQEGFVTNKSPISPQTVSNPIPIHARPAANSPSYYDLVNKYCFYGSDSPLSRSPNSTPAIHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHG9</accession>
    <name>A0A8H7UHG9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHG9"/>
    <dbReference type="OrthoDB" id="5282002at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046824">
        <property type="entry name" value="Mss51-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032717">
        <property type="entry name" value="Mss51_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069:SF1">
        <property type="entry name" value="PROTEIN MSS51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20179">
        <property type="entry name" value="MSS51_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13824">
        <property type="entry name" value="zf-Mss51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial splicing suppressor 51 zinc-finger" evidence="1">
        <location>
            <begin position="97"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial splicing suppressor 51-like C-terminal" evidence="2">
        <location>
            <begin position="210"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2185991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="448" mass="51345" checksum="506778A04F706996" modified="2022-01-19" version="1">MTTLRTLRPTVGRILLTSKGRIATTSIAISPAFRLSTRTFTRQLSIKSLFASNSDNDAKLSSTQRILTPDNLFHPISESPVPEIRDRGTIIRKYGMCPVCNEEHHGHREQMRSPAYECPDCGHPTHCSEEHYQKGKDEHSKICHILREHNEDEHDLRSGRPMKEFEFPSAQGFDEAVNMANWDVFFYTRSFPSMDSDRSMRHVSKLLTYPITIASALHESSPHRKQVTAEGLRSLAAIRSILYPKVQLARDGVTLLRTETVNLYLLGARAESTLPPHIWSQLAYLFPQTPFHIHFVGPDALPPNREPYTTSLNDQLTFTYDNAMYHDYHEKVGSFDPYKDVYFLFAPGLGHPSSRESWKASIAKALDTKCAMFITGFDKHDVETDVKTVEEDHAEDFDWILRPTENHFKSLKRDINLQDLTQAIFANWGIWGIRGKRYEVTHNPEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UI30</accession>
    <name>A0A8H7UI30_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Heat shock protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_003675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UI30"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140453">
        <property type="term" value="C:protein aggregate center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000134">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000021">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="613"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="613"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="643"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2179889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="71240" checksum="E6451E82DE4187F9" modified="2022-01-19" version="1">MSEGKAVGIDLGTTYSCVAVWQNDRVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPYNTVFDAKRLIGRRFADSEVQSDMKHWPFKIIDKETKPQIQVEYKGETKTFTPEEISSMVLLKMKETAEAYLGTTVNNAVVTVPAYFNDSQRQATKDAGMISGMNVLRIINEPTAAAIAYGLDKKVEGERNVLIFDLGGGTFDVSLLTIEDGIFEVKATAGDTHLGGEDFDNRLVNHFIQEFKRKHKKDISPNARAVRRLRTACERAKRTLSSAAQTSIEIDSLFEGVDFYTSLTRARFEELNQDLFRSTMEPVEKVLRDAKIDKASVHDIVLVGGSTRIPKVQKMVSDFFNGKEPNKSINPDEAVAYGAAVQAAILSGDTSEKTQDLLLLDVAPLSLGIETAGGVMTALIKRNTTVPTKKSEVFSTYADNQPGVLIQVFEGERARTKDNNILGKFELSGIPPAPRGVPQVEVTFDVDANGILNVSALDKTTGKSNKITITNDKGRLSKEDIERMVSEAEKYKAEDEAAAARISAKNGLESYAYNLRNTLQDEKVSGALEAADKEKLQTAVDEAIKWLDESQEASKEEYESKQKEVEEIANPIMMKLYGQQGGAEGGMPGAGGFPGGAPGAAPGGFPAEDNSEPTIEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIZ0</accession>
    <name>A0A8H7UIZ0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_006478</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIZ0"/>
    <dbReference type="OrthoDB" id="1939598at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="132"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2183472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="201" mass="22759" checksum="8C16104BD1781B9D" modified="2022-01-19" version="1">MSYISKLNEESSPELLSEESLARELDLWANAALYFEDPPLLKDLHSQSEADYLKAPVHDFLQHGSLSPYLPILPKPDLSIVAPLQDDTAFVNGSSNSSVSDSAAENRESKTKKNLKRRNDSVDEEDKVAMEEDKRRRNTMASARFRQRKKQREAALEENAKSMSAKVESLEQKVKTLEKESKWLRSLLVEKGGLLSSDHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJ98</accession>
    <name>A0A8H7UJ98_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_006798</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="4">
        <location>
            <begin position="64"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="5">
        <location>
            <begin position="954"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="702"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="791"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1419"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="508"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1335"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="708"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="807"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="819"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="830"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="855"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="874"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="893"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1425"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1435"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1447"/>
            <end position="1473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2183787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1489" mass="165877" checksum="90166A847A62D1E7" modified="2022-01-19" version="1">MELFSRGKSRKASLLPEAHQQASHVTPSIRSHSLPISNSSDSPTSPADNSSIKGFNDEGRPFSTVRPPDHEIEGLFEKMLTRRGIHDRGARSVMLSFPAEKKWLMVSQDIQADATTTVRPTMSTSASSRKSALESKELDKGTPEYYIKQFLEPDFRGINPKILAHLASGISSGKAKFLCWFSWVRTFIEARGLQVITNVLGNLNKRQIKREADLQMEIEIIKCFKSLLNNRWGAREVVMNPQCIYNCMQSMLSPPIQTRKQVCEVLVFMCYCEVPSGQEIVLRGMEQLRNATRDFGRFDPWFKLLETTLDGRGRMGSLVGASDDFRKLGMQGTADSHFTEFAISNLMLINSIINVVEDVDIRVHLRNQMNSCGLQRILSKLEELNNDQVTRHLNNFHQMADNDNEEIMESYNEQMINNMSDPRDVFECILSSVEGTRSYDFFLSAMQHLLLIKDSVEDRQVYEKTPRYFQLIDKVVTQIVLDRKGLAEDISSGYGMSVVEMVEKFTEKGEVQKALQDAKEARELYEQTLKEKKKIELELSLKGDGVVSQLKAKASSLEDLLRMSKHTISILQNKLTETQQEYQAGLARMDERLRLFHQAVLEATPASDSKDANNRASSFELTREELIRAYDRLRAQDRLEGQDFEKDGDVGGSILSQFQVQPEPMHTAAGLSDDFKNSLTNQLHSSIPGTFVVPGTAPLIGSTRRGKSFQERYSKDVDSGNKAGVQRKDVGKLPVQLQERVKNLLEKNDNETKVEKADIRPTSGLAIALQQKLSQQALGGTMVDTASEHVMSNTDTHKEQQSSSNIPAPPPPPPPPFMPSVSMQASSASVPPPPPPPPPPPAMPGGLTLNSNAAAPPPPPPPPPPMAPGGSYGIPPPPPPPPPQPALGGSFGTPPPPPPPPPPGTAAPPPPPPPPSSAGPHAPPTAFGPPPPPPPPGPGVSNVSHRVSLPTARKNMMTQTKVKTKALQWTKMNQQTISKTVWGQKTVDELALEMEMMEKGVFSSAEDLFAQKVFEPKKVVKKEKKPEICIIDSKKAYNINIALLSKLKRVPFSEVRSKILAMDFDFCSEILLRNMLSLAPTPDEMGKLSVFASSAGKDDLDSLSPADTFCLEMMKIDRYKERIQNMLFMRIFPDKNAQLSDNMQSVLDASIDVKNSKAFQELLNLILMLGNFLNGSGFQGGAFGIKIASINKLVDTKGSKENTTLLHFLVDIVESKFPRIYKFLDDLKSTDSACKVTLSDLIKEYNELRSGLQLIIDETKRENATDDRYHQFSEDFQKDAVPKFDELEVRYTSMDVAYKDVVTFFGENPKEMKPDEFFAIFKTFTSSWEKAMGDNVNAKKKLEQMEKVRQAEQERKERIAERKNNKGIDISEGKCGDIYYELENSNFSLVCQTAGATGKEDDKYLMDNLLDKLRAGDLDAGSRRRGDRNRRRANTNKISRSESVSRLAEDLLKDIQKDDSPSKSPDTEKQEKDMLADLISVAEIGTANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UK85</accession>
    <name>A0A8H7UK85_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UK85"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2181974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="102" mass="11189" checksum="62DB402D1A0F4B61" modified="2022-01-19" version="1">MAPKSIQQTLPKNRGKMSPSLRSRFGNLVSNHMRSSKARSHSLPPAARKRVPSPNLSDNDRASTVSIIRDLTPSLLSSDVEASPDSCFNRNKLLSFGSRTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKL1</accession>
    <name>A0A8H7UKL1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKL1"/>
    <dbReference type="OrthoDB" id="1057137at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039683">
        <property type="entry name" value="Lsm12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019181">
        <property type="entry name" value="LSM12_ABD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13542">
        <property type="entry name" value="LSM12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09793">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00995">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AD" evidence="2">
        <location>
            <begin position="113"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2182319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="211" mass="22747" checksum="A4937226904F1B4D" modified="2022-01-19" version="1">MSTVKGEENTSPSATTAGQSSSGSSNAGSKRLDTLIDCAIRIKTVDDEEITGKLFTVDPTTGCNSASNSTSNTFRIIKISHIKELISAQPKKQDDAKTDSIETAFSQANSAPRKVYIDQIKQREAEAIKLASQQAARTGVGVTKEAQAIFDALSKTLPCRWAKDTIVVMDEIIITPPYNEENCKANASSAAPLARVKKVLEGEKRRLQSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKM5</accession>
    <name>A0A8H7UKM5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CPAF-like PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKM5"/>
    <dbReference type="OrthoDB" id="27214at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056186">
        <property type="entry name" value="PDZ_CPAF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052766">
        <property type="entry name" value="S41A_metabolite_peptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049">
        <property type="entry name" value="PEPTIDASE S41 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049:SF4">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23658">
        <property type="entry name" value="PDZ_CPAF_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034416759" description="CPAF-like PDZ domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="CPAF-like PDZ" evidence="2">
        <location>
            <begin position="141"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2183278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="643" mass="72272" checksum="1A276A0375760E2D" modified="2022-01-19" version="1">MFSSNLFAIATSLLLATLPSPGRAQSSDACAVVAGKQIATYSEAKACLEHFPYNQTIADETIDIVRKITDDMYIFNEIAAHPPKIDGLSIVPVNISKSLDIIQKEPWKSDRAFQDAVALILDKVHDAHLVYSPHCYRQFIFWQPIQLNSVIRDGKQIVNVAYVKDDLWSEAKKDWTGCEVTHIDDKTAMEMVVNYAVNNNGESKDVNTCFNNIMNSKDYFHGWDDGADDLGYHRFLPDQENHRYTLQCPKNGTKPEEAKYDEPFTVTIPWVAEVPQSFTDADSYWDKYCAVHTSPLSKRSPTFQEDTIEETHIGQSFDFSINSAGTRTRDYTEFLLLDGPDSDIGVIDIQSFSVSSEDKTEFVKNFTRGLQMFEQNNVKKIIFDFSGNGGGDACAGEFFINSFFNSTPDYYSDVKYSPLVETVVEKAFEKQTTKWIDYKSNHSQGAEWFKETTTYDRGNAQTKFSQPVSLSCDSWNNAFADSNAFNTSRWKASDLLILSDGRCGSTCAIVVSRLRLVHDVPALGLGGIRGNRMQFASFPGGESERLSSFLTDLQSLDLLDTPGAPKPFPERADMGWTFREVYRPNLPGTDFGNEKNLLEYNNVAADCRMFYTDENASDPKKLWHQVASLLKNGQCPLVQNGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7ULR7</accession>
    <name>A0A8H7ULR7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_006465</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7ULR7"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF23">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="73"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="279"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="280"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2183459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="325" mass="36515" checksum="5CB18194BC572E35" modified="2022-01-19" version="1">MTGPGTPEKDFPQPIQPPPLAVANENDYGQISGSAPMFSYSPANFDNRTMQQLPVSTISPSTPLMSVAQHDGRSRFCEHCQRIKPDRAHHCRECDSCTLKMDQSSDVRLTIFNHSIRIGGCVGHGNYKFFFLFVLYTSLYSLWVFGTTLPTIIIAVLQKGNPVDVQWIVCVVLAFLWGFLLLAFSCIHGYYILTNSTTIESISDRPYFIRIDYDRSGHNYQLVSTDIGIKLWSLGMVANWRSVMGNNPFAWFFPIRNVLGNGFTYPFDPHVYQNMVERAAQQSRMSTTQSQLPNDSSIPTSKSPPADSNNFPMNQRNGSASELLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UP03</accession>
    <name>A0A8H7UP03_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SRR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UP03"/>
    <dbReference type="OrthoDB" id="551431at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040044">
        <property type="entry name" value="SRR1L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626:SF3">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="2">
        <location>
            <begin position="62"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2185784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="256" mass="29594" checksum="0879AC43C6D116F3" modified="2022-01-19" version="1">MEFKYQTVKSRRNKKNAKKKPFMKVSSEWTSSDVTQLLDRRREVLLESKFYADLLVMLKDKLVPTKPHDIVCYGIGSIQESKNAQFQFVLAILLRDLLKIPGTMYIYDPVFTDLDKEVCKNYDMDLIETNEQGKRTVDKPTLFYMPHCGKTLYSNTLSVNWSEKDLANVIVVGNRFENYTEGLLDRELKRDCPYLLPAVKVVACTPFPPEFDNNQIFNDLCVQAFPKDTLASVKSNFWQPLTPEPKTEDNVPDDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCG5</accession>
    <name>A0A8H7PCG5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">mRNA cap guanine-N(7) methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">mRNA (guanine-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">mRNA cap methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">INT43_002948</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCG5"/>
    <dbReference type="OrthoDB" id="10248867at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016899">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF2">
        <property type="entry name" value="MRNA CAP GUANINE-N7 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028762">
        <property type="entry name" value="ABD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 15" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="16">
        <location>
            <begin position="50"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="59"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>mRNA</name>
            <dbReference type="ChEBI" id="CHEBI:33699"/>
        </ligand>
        <ligandPart>
            <name>mRNA cap</name>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="15">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="15">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="15">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="15">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="15">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="15">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR028762-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR028762-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2171326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="324" mass="37455" checksum="8D31B586B2EBBE5E" modified="2022-01-19" version="1">MSKRRLSDDFEYVRKIAREKIDSDAATQAHLVAQHYNARPEVGVEKRQESTIIRLRSFNNWIKSVLIGRHVRRGDTVLDMGCGKGGDLQKWARGRIGYLVASDIAEVSLQQMEERYKSMRNAHFGAVFIPLDCYSEYLAPRLPPDVRFNLVSMQFCMHYSFESEQKARTMLQNVTSNLVRGGWFIGTIPDANWIVKKVRSLPRGEHEIGNSVYSIKFEDIKYNENGEKIGFTPMGCKYWFHLQDAVDCPEYLVHFPTFQKLASEFGLELRLKENFHDFYKSAAQDKDNNELLTRMKVVGGYDKEMSSDEWEAAGIYLAFAFQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCU3</accession>
    <name>A0A8H7PCU3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCU3"/>
    <dbReference type="OrthoDB" id="2445133at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23187">
        <property type="entry name" value="UBX7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="286"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="479" mass="52090" checksum="5F861F3CE4BC00B6" modified="2022-01-19" version="1">MASSSSVWFEGPVADAVAEVNAKGCVFVVFARDESPESETMASLLSEESVVQRLCEHSIAIQLFKDSGDAQLFAQLSGALIDVISGQTSNDEIITKFDKANGTSANQPPPPQPASRPAGPTQAVPAATASVVTTGTPPAPAVTGAAATPPTTLTTMQQTSSTASAQEKKERLKKQLEEIRKKKQEEEAKNTREKEIQRRRTGQDIQVAQESHAERQRKKYAEEVKKERAAEAEHRRKLREQIEADKRERAAQRQREIEERQKGNNSPASKPPSTSASASKTYQYIQRSSVCNLNVRQLDGSQIRKQFEATETLEVVMAWIDKERTDGDAPYMLLAQFPTRQFSFGDEARALRELDLVPSSTLIMKPSRKVTSAYTANGPGVWGYANSAADMAYSVAGSSWTFVNNVLSTLFPTSGGITGGTTLGAQSEYGENESSTSSDVRAAAAARDTRGNINTLSSISRDDDRDPNQTYNGNSVNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCZ1</accession>
    <name>A0A8H7PCZ1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">60S ribosomal protein L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_009040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCZ1"/>
    <dbReference type="OrthoDB" id="1478556at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_uL11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="6">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="5">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2171379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="19257" checksum="4F1FBA9FF5D378B7" modified="2022-01-19" version="1">MPPKVDPNEVKIITLRATGGEVGASSALAPKIGPLGLSPKKVGEDIAKGTADWKGLRVTVQLTIQNRQAQVSVVPSASSLVIKALKEPPRDRKKEKNVKHSGNITIDDVIEIARIMRYKSLARELKGTVKEILGTAFSVGCTVDGQNPKDVGDAIDAGEVEIPVSFASASFFFNYSRQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDQ0</accession>
    <name>A0A8H7PDQ0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_001495</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDQ0"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16293">
        <property type="entry name" value="CPSF2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000008">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035639">
        <property type="entry name" value="CPSF2_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="7">
        <location>
            <begin position="250"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2172018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="772" mass="87621" checksum="D3E1FAB0BBF901BA" modified="2022-01-19" version="1">MSSYLKFTPISGAKNSDPLCYLLEIDEVKLLLDCGWSDKFDVEDLQHFKRIAKQVDALLISHADVQHLGAYPYARGHLGMSCPVFATIPIVNMGRMCMYDIHQSKVNEEDFNLFSLEDVDQAFDRIISLRYSQPTALQGKCAGITITAYSAAHTVGGTVWKIKKDTDEILYAVDYNHSREQHLERSILNAAAGQGLESLGRPTLMITDANNADVALPKRKSRDTALFNTMADTLRNAGSVLLPTDSSTRVLELAFMLDQYWAKNQFTYPLILMTHTSYHTAHFAKVMLEWMGEEMTRKFSASRENPFDFKYMRLCHRLEDLEKYPGPKVVLASNKTLETGYGRDLFLRWMRLNQTETDAVNTLILTDRAQPGTLAYQLYSDWENKNAELEAEGGEKPEIRPPIQYNTEFETVIHEKVPLEGEELEEFETKRRELAEREAQQAAIMARSRVIMEEDESDVSDTDEPDDVNLEDLLTTQFDLYVRDAGKSGGFFKQTHSYRMFPYVERRKKFDDYGEAIVVDHYKQASDIEQLQEIGTGANFGGGEDVEMDLNEPILPARDETPTKYISYEEKVAIRCMLQYIDFEGLTDGRSIKQILSRIAPRKLIIVHGTPHATEQLSNTLSSLEHFTKDVFTPDVGEVLNVSAATNIYRVKLTDALVSALQFSKLDDYELARVSGRIRFPDSTTPTLDLPSSQDQVPFEPPVFVGDVRLREFRKVLQAEGITAEFKGELTLVCNDHVVVRKMGTGQLLIEGLLSPDYYKIRSLLYAQHAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PED4</accession>
    <name>A0A8H7PED4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_004921</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PED4"/>
    <dbReference type="OrthoDB" id="1588579at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="188"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2172379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="558" mass="61964" checksum="C63B92CC5F4D148D" modified="2022-01-19" version="1">MSLHLEQMPATLMATSSSSLPEGPPVNGYLGRYNGNEVNGTSNVRTFNKSKRRAAQQIHTSFEPSADAGPASATIKATATEGNGTAHKRSMSHDMYGNGYPLQANEKSPNLYDNNGNGHFQVHTDDITYNKPELHSRGSFIDSTISRLLTRPETPTISTRHTDASSRTWSVPNLLAQYHISLSENFKFIILCLMWYSSSAFTNNIGKQILMQFRYPITLTYIQFGLVALSCYVVTKLTGSTQIRKLDMNVLKTILPLAGFQIFGHVFSSVAISRVPVSLVHTIKALSPLFTVLLYRFLFQVHYASEVYVSLLPLTMGVILACSFTFTNNVLGLFCALGSCLVFVLQNIFSKKLLFKETGGHSRREDKLDKTNLLFYSSLMGFILMTPVWLTNDGYVIIGSLFSGEAPPHGVLSSSVLVAFLLNGLMHFGQNWCAFTTLSLTSPVTYSIASLIKRIFVIVASIVWFGQQVTLVQTFGIIMTFIGLWMYQSAKQDVDRGESKIREKSLGGTLPTSNDRSFENGPKSYGWTEMNRQIQSLGNSIFSRIRRQPTPDFGVKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEG4</accession>
    <name>A0A8H7PEG4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_008221</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEG4"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="6"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2171841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="390" mass="41843" checksum="08A4DF07C9BF260F" modified="2022-01-19" version="1">MSEIKNVVVIGLSYSGVSTANELAKKLPAGYRVLAIERNEYAFNPVPALRAAVVPGWEDKVMIKTDKLFPANSAHKTLVGATVTKIDQNSVILDREVELDGKATSSIPFSYLAVATGSVGHFPIRVPDYQGPEDAKKAFQKLQGEVKDSKKLLIIGGGPVGFEFAGEVTEYYNGSKGKDKKEITLVNATPRLLHIDVKDGVHRKALSALQKSGVNVILGHFVNDIDPTHNGALGKTQTFTLDDGKTVEADFVLIGIGSKANSSLVVESFGQDAIETPTQQIKVRNTLQLESQDNIFAVGDCNNVKENKQAAWTGKQATAAADNIVALITNSTLKEYGPQSTIIMVASYGTKDAAGQLPFGFGVPSWLGTRLKSKGLFADKFAESFNTTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PF30</accession>
    <name>A0A8H7PF30_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="12">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_000116</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PF30"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000013">
        <property type="entry name" value="Small nuclear ribonucleoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="13"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2172769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="85" mass="9878" checksum="3D53DC88A134A764" modified="2022-01-19" version="1">MSTKVQKIMVQPINLIFRYLQNKSKVQIWLYDQLDNRIEGKIIGFDEFMNLVLDEAVEINNKGQTRKEIGRILLKGDNITLIQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PF38</accession>
    <name>A0A8H7PF38_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_000087</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PF38"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF15">
        <property type="entry name" value="SPORULATION PROTEIN RMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="198"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2172740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="424" mass="48865" checksum="80A0D529738DC01B" modified="2022-01-19" version="1">MSKRPSKRQYPNDPATTPLLSGQQQPSKSTPVSASKTIAFNSQSHLAHGLPSSDHYHTFHQDTPQPTRPKPKQPNRTTKTSQKLKLFPEEEDHKLISTDDIDTSVYDQIAQIPHGDARLEAERLSKGDRGHLPRVTAYCTASAYRMDDLVKYLKSKKSSNGAAPKRFDECVFTPFSFKYPISPLRDDGEEVKQFMPEVFFFDYGVVVFWGMSIEEEQKLMQELEPFEEERLETDDVEVEEFHFHYNERYQPRIYNDVITLRHPQNYLVKMTISHAIAQSVKMTLFERLIDDTINETKYIPQVMAESGKVHMSRVAITKKIGQLFIMRINVNLVSNILDTPEIFWSEPALEPLYSAIRGYLEISQRVELLNQRVQVISDLLDMLKDHLNSSHGEQLEWIVIWLIAMEILVAVITTCLDAFSLSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFP2</accession>
    <name>A0A8H7PFP2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_004470</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF13">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8 12" id="KW-0518">Myosin</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="870"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="907"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1175"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1570"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1597"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1625"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="16">
        <location>
            <begin position="7"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="935"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="17">
        <location>
            <begin position="1812"/>
            <end position="1867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="593"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="12">
        <location>
            <begin position="632"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="758"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1743"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="109"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2173097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1870" mass="212362" checksum="7D0748CADE066725" modified="2022-01-19" version="1">MNSPIDGIKPDLCRLQNPSADSVTAALQSRFKRDLFYTRLGPHHLVVVCGYKPSESLNDYALKNNADAIYRDLDNRSIAMVQPHIYELAARVYYQLRRTGDDQTIILSGMTGSGKTTSHGHLLKQLLYLSAHTKKASKLQNQINNSQIILQQFGSSRTLQNTTASGFGHFQELQYNERGRIIGLKTLTYNLDKSRVTQVPVNERNFHIFYSLISGTSPEERTALRINYAPEYFVYLSQTRNTKAIDAADELAFADLKAALKICGFKSKVVTQMFQILAAILHIGNLQFVDPADSTQDSCSVKNTDILEIIANILGVAAGKLESTITYNLRYVGNELCTAFLNAQAAAQQRDSIARALYGAVFNWMVEMLNTKLCCMENDMYSFVGILDQFGYQNYKSNRFEAFTVNYANEFINVFLQQQRPQELLMAEDGIKDHVVNAVDAPDCMSLLTGSSGFFANSVGGLTATINKESARYLANESDATDANLLSLLSKLYSSHPCYIKSSQNFAFEINHFHGPVDYSVGSFLEKNTDIVSPDFINLLRTSSSNPFLVNIFQSDNVATKPHPHDERTIIKAQLPTRSMRAPSTKRSLRRKASNVTDAVNNNNNAMTKAPSADTKPEVGLTSTLDQLHDTLCSLIATVQDTRIHNVLHIRPNPAQAPDQFDAQTVKAQVQAFDISNLCDRYRPGYVNMYTIPEFLARYPTLIEDLPEEIDDLTKVETLMQNHEWKAQDVVIGHQHIWMTFEFWKSIEDDKRRLEKEERETIKGTEIESAPSEAPREYAHNSHDMYSSKFDSQLLPPLPGFHDDKGSYVGSDEEAKKYEGSQWGEESEWGAKALAEGYGPNMDMSQMVDDYRDIQQEQVEEMPISAVRIWWVRFVWFMTWFIPSKFLQWFGKMKRQDVQMAWREKLVLCMLIFLFSALTLFFIAGFGELVCPGTKTLYSTQDVANHNLINDFYVSVRGKVYDMTKFVVTDHGTGQYASTRSSLEPLAGQDLSSSFPIPLTAACPGLVTDDLVKVTPNDTQVISSFVHYSGSQQPDLRLTKLKDNNWYWDYFLPVMNLYKKGDLVIPMKTIQDDYNNWGRLIVSLDDKVYDFTNYMNTAKYYPESAPGVPNYRYLDPVVETIFTKFGGSDATSEWNKYKKTMQPDVLTQNQNCMDNVFYIGRLDYRDDPRCTFTNYLLLAFALVMCLVTLIKFLAALQFGGVPTPEEYDKFVIVQVPCYTEDEESIRKTINSITTMNYDDKRKLLFLIADGMIMGSGNDRPTPRIVLDILGHDPKMDPEPLMFKSIGEGSKQLNYGKIYSGLYEHEGHVVPYIVVVKVGKASERSKPGNRGKRDSQIICMNFLNKVHFESEMTPLELEIYHNIKNVIGVDPSFYEYVLMIDSDTEVMPDALTRMISCLLHDGKIIGICGETSLGNEDNSWTTMIQVYEYYISHHLSKAFESLFGSVTCLPGCFCMYRIRTPNKNLPLIISPKVITEYSENHVDTLHKKNLLHLGEDRYLTTLMMKHFPQYKMTFTPHAQCKTIAPDRWKVLLSQRRRWINSTIHNLLELVLLPELCGFCCLSMRFVVMIDLIGTLTLPSSVLYLIYLIYVVASHTGPIPVIALSMLAGIYGLQALIFIIKRQWQHIGWMIIYVLAIPIFSFFIPIYSFWHFDDFSWGNTRVIAGDKKKQIIVADDEKFDEKMIPLKKWSTYEQELWEKDSFESAKTGLTAHTYRSHYTHASQNASYRPTGEGFDYYRDSVKTHMEDRRSKAGSRSHHAGSAAGSVAGSDYHAYPRPPMSVHSFGHSEMMQRPPSNFDASVMSIPALSNHSTGFPSDREIVAEVRNILATANLMTVTKKQVREQLSLFFGVDLVCKKDFIGASIEHILQGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFT3</accession>
    <name>A0A8H7PFT3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFT3"/>
    <dbReference type="OrthoDB" id="10542626at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2173157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="57831" checksum="700B8E8A8D23163B" modified="2022-01-19" version="1">MSGLWESLSVELRLRIAQYLTAQELQIASSSCKLLYQFFANQDIWENAYTSLLNGYPKTNFSITRLVRDVKRLDFVQSEVVSAVQQKTYIFEPAGHIPLYDSTFITALESHLGAVLPIDFVIFLLNFAHQITFQTGKDEHLQKALLASGRIFEDRWNWQEAIDEIYFAEYDENGYRTSDDRDGLLTSSSRSYMNEMTIACFSLLYSIYDGDEKAYIGLILDADQTLEDDIPRKIDEPELQVDFESMKRGVGKVVYNLFSKSGNVYKLNAIAESFTDYLVHWGSVVIIIGQIPSIDQDGYEDIKRRLPRHPKSLSSVLLPQYHGWSVAKASHGQILINPQEPQREDALSFHICIGQPKCQINIETYGVQQQMIDAWADLTPFERQISDSPMPRVDRVRQHTSHIRTLFDTLKSRLPVALHYNREWRGRISLCYYKCFLEHLQALDLDAYKYNLEELSNFELELRKELNNIRHMTIDHRRIALGWAVNLDAIADLNIDWSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGS0</accession>
    <name>A0A8H7PGS0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_005102</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGS0"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033229">
        <property type="term" value="F:cysteine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="74"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2173682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="524" mass="59073" checksum="59D460C8DEFF6E71" modified="2022-01-19" version="1">MGSPAEEDGRSVHSQLSEHKGVTYLEQVFSGGEKSNMADYDRIDPEVAKYASEKAIHIDEETNKRLKRMIDKRILLVMCATYFLQSLDKATLSFSAIMGLQKDTGLVGQEYAWLSTCIYIGILVVEYPMNWTIQRVPVAKFLAFCIICWAAVLCFHALCKNFVSLLVVRTLLGIFESACQPAFLALSSMWYKREEQALTVTYWFMMNGFQQIFGGLLAYAFTNITTGPLKSWQWLFLSYGIISVFWGIFVLWYLPDSPMRAKCFSEEDKKLMVERVRSNQTGLQNRKFRKDQAIEALKDPQVYCYGLIQLFTTLPQSGIGAFANIIINSLGFSVLDTQLLAMVLGVLIMAMPLTSAYLVKKYNQTTLTMVGFLIPSIIGTIVLMTVANIDLATRAGLLVAYYVVLSFWGASTLALTLITKNVGGQTKKSIAVAVNFFCWAAGNAIGPQVFQSQYAPRYFSAFTVHLICYVCAIATLLYLRYHFKKMNAKKAEYLEGKGKGKDTDYLKSFDDLTDRQNPNFTYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PH18</accession>
    <name>A0A8H7PH18_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_005118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PH18"/>
    <dbReference type="OrthoDB" id="1290869at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13971">
        <property type="entry name" value="ADCK2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044095">
        <property type="entry name" value="ADCK2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052402">
        <property type="entry name" value="ADCK_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890:SF1">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2 (PREDICTED)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="177"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="267"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2173698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="667" mass="76898" checksum="A8E58314DAAD4168" modified="2022-01-19" version="1">MRLRLQPLTQYTRPWQPKPLSKPISISTAVSYTAYSRFALASLPLAHLERKYQKNNHDISTPEDIEEMRAEPSQRKVIRIIDRILDWLDTWFLEPILVCKRFVHVILLFSPIVIAIPIAFFGAKNPDEHDERSGTIWWYNLIMNQMELAGPTFIKLGQWAASRTDLFPLALCSRLGKLHSSVTPHKFSYTRRVIEDAFGGLPLHYVFSEFEETPIGVGAIAQVYRAKIRPEFAEGHKEDLFALQDQELSPNSVRIMDDKTGESLNIHTSVAVKVLHPRARKTVTRDLRIMHIAASTISLIPTLEWISLPDEVEKFGEMMQEQLDLRNEGQNLHKFNDLFKDNMAVSFPRPMLRFTTKSMLIEEFANGIPMSVFLEQAQESKAKHQESGVFDHKIADIGLDAFLHMLIFFNFIHADLHPGNIVIKFYKPSAYHKFQQAWSKLLGRDLKDDGDIAVERISAVRHDYDLMREELVKLKEEGYSPKLVFLDTGLVTELNEVNRRNFLDLFRAIAEFDGYKTGKLMVERCRTPELVIEPEVFALKMQHIVLDIKTRTFQLGQVKVANLLHMVMNMVRDHHVKLEGDFVNVVVSILLLEGIGRQLDPSLDLLKSAIPVLRDFSIKDGAKGALDRMKSVEDIKGATPWLKVWFYIEAREWLATNTRENEWMTLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHJ6</accession>
    <name>A0A8H7PHJ6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ASTRA-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_004169</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat ASA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHJ6"/>
    <dbReference type="OrthoDB" id="7668193at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="158"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2174149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="195" mass="21840" checksum="25D1A26E19B9682B" modified="2022-01-19" version="1">MDPSQLDIYDLLEQRRLVADIGQEEISTDSRDTVMALQMYIREDHVQLLSGYESGRMVLRIISGDKADTVWVSQRHSSPVLSVSARPDMNLLFSVCTDGVVVKSPLFEQDPAATKQISTKSGLEQVCVRDDAKIIATAGWDNRIRVFSAKSLKPLAVLSFHRESMYAVAFASLPSDHHYLVGGSKDHRISIWNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHZ4</accession>
    <name>A0A8H7PHZ4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHZ4"/>
    <dbReference type="OrthoDB" id="2221257at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2174266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="834" mass="93723" checksum="84EC1CCDA013035A" modified="2022-01-19" version="1">MTLLLTKSCHYAVLVAIEEGRHFPDNPDHDVFIQSRLNLVLPSVVDDLIPPATLINSVPVSTTPNPAWRTTLAYFVSAKLLRRLRKQGAQVRLDISTLSLDSRHEVIGSVSLDVKDAKMVLMKNGKRELREVEAYVVDKGNWLSLSPPSSSKSNLPSPCPEIKAGLFVLDMPQAVSDLAARSSTPVPATFTKRALVKNDPGLELCSSSQIMEHGDTAPSSMASEEDDDYDDDDVDIDEDDVVSPSPSTTLYDNKNKGLPRRVQSHNNIPNIGLRSEYARKRFSSSASHAKVNLEKLSAAFTGMNIDTNEIPVPSQSRRHNRTTSSASFSSVNANTPQNGQSPKLPYRQIGTGTKPITFYFNIVHADHLNSLLRVKSSHIQQQPRPFFRYRFLSNVVIAPASSLSLLNKHSRRSASPKITFFHFRGHARDVQSWLVRQQKLWIDLIVKSDPSDDEEGEIIGLCEIPLTGITMAAADLLQRSPNESDDYFYGTVQQDSIEKVLPERSFPVYDLKTRGLLVSAPKEIARVTVRMGLVAGWWNDEGLTNQPDDRAARVKSHRSSLTRVTQDHVNNLKRQNSNGAEQFEQLLKNKKLKRAISEQGSPVKPSSRQSRFVPPKPLVIPETFSFAKDDDLSTTDDNDVDRYDSLDYDVVPSISNRRLHDQRRKPLEKSLMRGHSDLGPYRETSRRPSTDRNKSIDDILMPPPSSTSSLQRRLNRARTHSSSWTTDVLAPVPSLTADSDTINDDYDESYQESLTQMYSEALDLMRDHSMRWSKVKTLVTSEVDRVLRERQRLAEFRKNVEVMLKTKRAKDHGIAKPTLAGRTRLSDKRLSGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIB2</accession>
    <name>A0A8H7PIB2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIB2"/>
    <dbReference type="OrthoDB" id="6359943at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2174373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="298" mass="33663" checksum="D58E1F0203CABB32" modified="2022-01-19" version="1" fragment="single">IMQNPDYPDLQNEEHEIIYHEIFSTAIIYTHMSFDQLEKIQKDRDEITGLRYAPDNVLKDALWQQIELRSRIESACERETDLGLTTSAINDPMNGKAGLRYAIPSDDTTTSTGESALSQAIGQKSESTTAKSVSSKLLSSETFMKTYSNYPPFRFSVEFNDVAALKPNVKVYSKNIFYAGSIWNMYIQKHKSQRKGPLLGIYLHRQSIPNTSTSHSGMGAINEQSNSHDHGSPRTRTDSISAAATYSDRRKCVRTWFKIFCPARGPNHALTLFQSCPDEFTVSQSWVSLTEILLEKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PID5</accession>
    <name>A0A8H7PID5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_004426</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PID5"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2174403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="152" mass="17855" checksum="BCCE63EDACDC4C6D" modified="2022-01-19" version="1">MINISQLCTTYSTVIRRRNRLTAEKTESMNRLFILNPRPDRLERQKIASELDIGERTVQVWFQNRRAKVKRSPREKESSSAASCQAPEGKSFAQEAKEHKRAFELTRSRALSMTCPNTLPFHNWSWVPNNVFATEMLLEREYESEDIYMPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJA9</accession>
    <name>A0A8H7PJA9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJA9"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="1">
        <location>
            <begin position="20"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2174790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="216" mass="25051" checksum="571B392DB9C6EE12" modified="2022-01-19" version="1">MLSILANNQSPEKIEKDALMRRFIIQEIYTTEKSYLKNLLIVKTKFMDPMVEAAKLGSPLVRSQDLPILFAHLADATNISSTIIKRFEHWKETSGMLWRQSPVRVGKIFIDLNEEMGCYVKYALDYHSLEKALKRAVRNVEYQKFNQDSINNLETNRMGLADYLIMPIQRATRYGLLLKDLKKHTHVNHPDYNDLDIAIKMINALATAMNHAQKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKJ9</accession>
    <name>A0A8H7PKJ9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_005978</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKJ9"/>
    <dbReference type="OrthoDB" id="8093034at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF20">
        <property type="entry name" value="TIA1 CYTOTOXIC GRANULE ASSOCIATED RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="287"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="378"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="483"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="8"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2174916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="621" mass="68887" checksum="5CA280E0C264FC7B" modified="2022-01-19" version="1">MIDLLFLRTSPYSRETSPAQSREPSPTVMEIDTAHHHPGNHFNSELSEPIYTSSVSSEGTMTPTESSASCSPNFPGNNHSEIQHASLIPDHEPTETRSEFMDMESSTPIDPFKLRYHLQRTINTALGGRTSNSNSSSSPLYSPITSPRTPPIPINDPTDDLDSDTPIYKNEEREPAVDQAAVLGDLHHTSSEDLMDEIYSGFTEKAKDGHTGCGQNCQCGDVCQCTGCTLHTRQPSSNDQNALDGQKSSQFEPIIDEDGVQLCGCGCKKSLESCRDCFQDLCEDGCKAVYVGNLDSRVNTAKLTDLFPANDRIRRIKILPDRHHGHELKSYAFIEYSDHLAAEEGLRTMNGQNIMGKTIRVHWATQGQVHKEDTSQHHHIFVGDLSSEVTDTTLGETFSSFSSMSDARVMWDQNSGKSRGFGFVSFEDRTEADKAINTMNGVVLGSKAIRCNWANQKNSRRDTTVNHALSYEQILRQTHISHTTIYVGNLPHYIKEHELAPFFQQFGYVLDIRLQGERGFAFVKLDTHINAAIAIVSLQGVNIAGRPARLSWGKDRATNNYTFTTPTPAPPAPYIAQMPAPSPVWVESNGQQPQLQPWMGVYYPAYQPTFNAITGPLEEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMA7</accession>
    <name>A0A8H7PMA7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_005544</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMA7"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2176310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="204" mass="24153" checksum="30A808E9F810EB45" modified="2022-01-19" version="1">MGAYKYLEELYKKKQSDVFRFLLRVRCWEYRQLNVIHRASRPSRPDKARRLGYKAKQGYVIYRIRVRRGNRKRTAPKGATYGKPVNQGINQLKYQRSLQATAEERVGRKCANLRVLNSYWVNQDATYKYFEVILVDPNHKAIRRDARINWIVNPVHKHREARGLTAIGKKNRGHGKGHGFNKTIGSGRRASWKRRNTLSLRRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PN27</accession>
    <name>A0A8H7PN27_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_007605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PN27"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF50">
        <property type="entry name" value="BIFUNCTIONAL ALBAFLAVENONE MONOOXYGENASE_TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2176951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="29205" checksum="65084098E8552A32" modified="2022-01-19" version="1">MDGFGFDFNAINNLDGEWVTTYDDIADNIADFQFLFLSTFDTTLLSLFPARQKHHNSVEKMDKLFYSVIEHKKKALSQAKTDVDERHDEDDKLEPLSSIELRDELVVFFLTGHDTTANTLTSAMYFLAVNLDIQKKARDEVLRILGDDYSDISPTLHQLKEFKYLNNVMKEAVRLALPAHSLIERTVSRDTEIAGTFIPKGSLVKANILGLHYNPNFWNEPAKFTPDRFCEGGELESRSSIYSYLPFGGGYRQCIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PN75</accession>
    <name>A0A8H7PN75_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_005734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PN75"/>
    <dbReference type="OrthoDB" id="10374233at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2176494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="356" mass="41077" checksum="32E03FCD7102F924" modified="2022-01-19" version="1">MVSAEDSVKKYYQWLHLQRQWKKQYSEDPKLDAALHAVLQPEVLFKDGSDMSTIPFFIGVSQKDNYSYILLPEDFVPAVRQCVHSLMISRTNGEAPPPAGPLSQGKRYLYIRKVLFKNRASYFNTISELRIYNGRVRWLDQQVTSCQFIRKSVILKNIVIFSIHVKSEEKEIREIAWTMYDMRRQRVLDQHYIVDGSKVATEVGNGPIHMDINQIMDILGKDLDWADKRDKKLAVVAYDTGKTMLTLKHHGWTRSWQQDSSTRPIQMFSVKELYEVFFNQLGYRAPLEEILQSLDLPPQLLEDTGCVARQLLMAVIEFAKRTVPTVAQFGDLMQSKPKKAPSAAVKYNVKNRLTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PN80</accession>
    <name>A0A8H7PN80_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007794</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PN80"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF24">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="3">
        <location>
            <begin position="315"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2177137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="676" mass="76771" checksum="CA52A088F991AE35" modified="2022-01-19" version="1" fragment="single">PYTLSIDMLGRKISNKSVITNDNDDDYDELLSSVEHFYEIQNAAHHRRDRAILQAHAREASSRPVKLFRNLTSFLRRAIPQDGLPEPSRAKSWPIVNFVIRSYSNLALTFLFDGKMLIFSPVNALLFLTVYPFMIVLLITVELTLKVFLDYLGGQALVTYLSIFCLSSATPHLFHGPGVEDLMLSTIPTFGERPSDAKTSNSTHVRYFDISKAEVMTLLSALIYERDANKVKDAYQLYATSDEKEDDAKKSDEIDETDNTDLADRTRRLLWESEKRIRHIARRWGLRFAGVSELKSLGGPFCGMFWSTEHNCIIVTLKGTTVDNYEEIMLDAAIQRTDARAFLFGACHQGFYESVFPSSGSFENDTRDPYGAILTALHERAKKIQDHRKSKDPVNVWVTGHSLGSAMSCLIFARWLRCPDDLDSKICVLRDAYTIGTPGVGDNDFAAGFASYTNTPYSRTSTLWRIINQSDIVARLPIGTDNPVIGRYFSRNDFFNYSHVGQAIQILSKWHEKPVKIYPSTYQPSLKVQVVLGAYNNSSYTNDIHGQEPFSQSEESYTVSSPTSTESTTDSPSGSQFLQLTKLRRQSTGDKPIFDSYKPIPMLLQKLDENGWFNKLDRWMKGSNPIQAIEGVYPFWFMDHIPHSYYSSLQRLRQYYEQHPSSTVKAPQTTSEKPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNX5</accession>
    <name>A0A8H7PNX5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_007925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNX5"/>
    <dbReference type="OrthoDB" id="1938621at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120510">
        <property type="term" value="C:mitochondrial [4Fe-4S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000006">
        <property type="entry name" value="Iron-sulfur cluster assembly 2 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="6">
        <location>
            <begin position="80"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2177268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="192" mass="21499" checksum="B05334E541517920" modified="2022-01-19" version="1">MQKESLIIMLRTTFTTTLKSRCLHTRAIAVVPSAALTTAPLRLYARQSSSIIKPCQRSFSSFSALHSQFRQADQTHGLLLSDRAVKQLQFMNKRDNDPDQMLRILVDSGGCHGYQNKLDLTSKVEEEDIVFERDGARVVIDNVSLQFLKGSTVDFVEELIGSTFQVVANPNAKHTCGCNISYDIDLDMITQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PP85</accession>
    <name>A0A8H7PP85_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_007705</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PP85"/>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2690:FF:000002">
        <property type="entry name" value="Splicing factor 3a subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="11">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2177049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="231" mass="26047" checksum="E3BA120047A78B8A" modified="2022-01-19" version="1">MDFQNRVGSKTGGGGVASASEANVNRRERLRKLALETIDISKDPYFMKNHLGSYECKLCLTLHTNEGSYLAHTQGKKHQTNLARRAARDAQDSSNVAAATGSNQGPLQPRRTVIKIGRPGYKVTKVRDPVTRQMGLLFQVQLPQIANDVTPRHRFMSAYEQKIEEPNKSHQYLLVAAEPYETIGFKIQSKEVDQSSGKFWSHWDKDSKQFSLQFFFKNTSFENDAANANSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPB3</accession>
    <name>A0A8H7PPB3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008002</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPB3"/>
    <dbReference type="OrthoDB" id="42657at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2177345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="541" mass="59575" checksum="E35CD99DF24F00ED" modified="2022-01-19" version="1">MSTTPIKESIHVEDIKVDSADVEAINLDKQLGGSLLPGEGPSSEPETTRGELWGFYTFAFAADGYLGATSSVFQPLIISAMATLGGRSTLDHTKACISADNCEVLFGTVWVSPTSYSLYSSAVSVAVQAFVAISLGAIADHSGYAKVYLFSFAYLCSLSVILWIALQDPRLYYAANILNIVGNVCYGSAFVFYTSYIPKLARNHPEVLNASTVSEKLEKLTFRTSRISIFGSASGFFGGFIQMLIAVGILYAMNETLFSMKVATMMGGLWWALFAIPGIFLLKRRPGPPLPKGENYLFYSWKKTYQKFRYAKRLSQLFLFLLFYFFVSDSASTILKVAVLFAQNEIHVSNENTLMGTLVELGCAVPGMLLWHWAQKRFKWKPKTLVFALTLLTGALPAYVLGGFSSLPGGFKSPNEWWGLCAFYGLMQPALYAFCRALYAQLIPRGHENEMFALFSITAAGGGWIGPLICGVIGDVAGTIRYAMIFVVAGLYLPLILLYFIDIDKGIQQAKDVLQQELGQIQLQEQHAENNEEFVLLSSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQ44</accession>
    <name>A0A8H7PQ44_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Lariat debranching enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_003269</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQ44"/>
    <dbReference type="OrthoDB" id="407609at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000035">
        <property type="entry name" value="Lariat debranching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="14">
        <location>
            <begin position="370"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="549"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2178016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="581" mass="65666" checksum="645CC3E96A727EF2" modified="2022-01-19" version="1">MKIAVEGCCHGQLDDIYGSIRLLEHKEEIKIDLVLICGDFQAIRNVADLECMAVPPKYRQLGTFHKYYSGSKVVPYPTIFIGGNHEASNYLWELYYGGWAAQNLYFLGWGGVINFGGVRIAGSSGIFKGNHYRCGHYEKAPYSSSDLRSIYHVRQYDIRKLGLLRQPIDIMLTHDWPRGVEQFGDVQKLLRVKKYFRQEVARNELGSPANEELLEKLHPKYWFSAHLHVKFAAIVNHDDWVRRNDGPVRGSEHNQQAQTMVNPDEIVIAFDDDDMDTPAPNPDEITIDFDEAVDAEPSTKQVQSTVDPNEIIIDDDFDDIGADEIVDTNEGVIDIDEEISKKVPAANATDISHNVTTPHDELINENTEKTPMLDPSETKATRFLSLDKCLPGRQFLQVLDVATSEESFTFQYDLEWLAITQVTNKYLSMEYGQPPLPSDESLYRYVYKEPAKIVLYLTTLASEVAEKMEELQQKVANGTIDLAIPHNFVPTTPAHDDSKPLTRQEVSNYVYPFTNPQTESFCQKLEIENKFKSSNTEMVPPMAQAVVETLATEETAPGDATPPKRPRLDLPSPKGNDDIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQ67</accession>
    <name>A0A8H7PQ67_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQ67"/>
    <dbReference type="OrthoDB" id="201656at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08252">
        <property type="entry name" value="AL_MDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014182">
        <property type="entry name" value="ADH_Zn_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051603">
        <property type="entry name" value="Zinc-ADH_QOR/CCCR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02817">
        <property type="entry name" value="adh_fam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154:SF1">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="12"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2178187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="337" mass="36818" checksum="EA59A66F803B503E" modified="2022-01-19" version="1">MANKAIAISQAGGVDALQVTTLPLKAPTGWDILVKNYAVSVNPVDAKQRSLNKGWTEAWRVLGYDGAGIVQDVGPNADSLWKKGDEVWYAGNVMRNGSNSQYTLVDGRIVGRKPKSLDWVNSAAFPLVVLTAYELLVEKMDIQKNDDGGLLIVNAAGGVGSVAVQLAAKILGMTNVIATASRKETIDWVKKLGATHVINHREPLEPQIKDLGISVKYVALFYDPDAYIPQVITFIEPFGKIGSILSPQKANFLTAHMRSITLYFESMFAKSMNNVNPESQGQILNDFAQYVEDKKVIPILTDSYPLTLKNLQKAHKEQESGTVLGKIALSIEENSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQJ0</accession>
    <name>A0A8H7PQJ0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleolar protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 4">Pumilio domain-containing protein NOP9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003301</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQJ0"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="586"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="684"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="751"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="684"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="762"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="814"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2178048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="823" mass="93637" checksum="CEB7253802EEF945" modified="2022-01-19" version="1">MPREKRQGRTRGKKGKKDKEQEEVNDTGFENADYNNAMEVDAQQDSTGFQQDPNGFQQDSHNFERPRGYDPSQAFYGFLDADVQQYFKNVEQTLDDPPFETGQDQQLFVANIYSEVENKELILATDHSCSMVLEKLLKISSDFELRVFMDRLTGRYAELFTHRFASHVCQTLLTLSADIVEREARGESIPGPNEEAQKGKGEEVGVLLSMEQLVLSLCKELKPQVCTLISDQFASHVIRVLLYLLAGKRIDEENDVKGQLRSKKSQKYRNTNNNKDVKASTKASPTRVVPASFKAMLEELTKTLTSGLSETVVRTLAVHRVANPVLQLLLELQNDAEDGQKVNDMLVDRILWGIVSDETPGPNSDRDAWFETLLRDQVGSHLLEVVLKTISPSLYNKIFVTYFRNRLVKLCHHPVANFVVQQLFVNARTSVQLELMVEETVSGFADYLKFGKVGVIRSLVDACVRLKACEKQVVAGLCDAFGTHSPTERKDFINCVIRMWPYQQWIYASDEEKTSLKKFHLQGSLIIQTLMKLPEEHNNIVVSSFLAQPQDVTYRWIFDPTGSRVYESILGSPNTNLKIKKKILRNLEDKYHEISMDKFGSHIMDQCWKVADIDMKAKIAQDLVNHEYDLSKNFFGKYILRNCNIDHFKRKREEWEEKEKGIERKKEMFKDIIGDAALISSQPAGANIPANPNLQDLGFGDGVSQETSTASKDKKKKKKKSVNDHSKSLLLDGETQNEVEAGMDDIDKVFKKKKKGASSSSKKHDDEATENHAPEKKDTPKDLLNVLDAIDATNKSKSKKKKRSKDKDGDEEKKKKKKRKFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRB6</accession>
    <name>A0A8H7PRB6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1A58)-methyltransferase subunit TRM6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_001718</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRB6"/>
    <dbReference type="OrthoDB" id="10254665at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038170">
        <property type="entry name" value="tRNA_m1A_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2178872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="433" mass="49168" checksum="9241A5EE0CF18E0C" modified="2022-01-19" version="1" fragment="single">METATVPAITTEDDITEDFPHIKANQCLFLQLPSGNVKQINLKPDTKISLGKFGTFKANALIGQPFGLTYQIINNQGDIKPARNMALEDIEETEADNREIFDTKDAQKLTFEEIEKMKQDISDGTEKESELIQKMIQSHSSFDKKTEFSKAKYVQRKKKKKVFIRALFSKQFTPTRPTLYSVAEYFFERNPEKIGYMRVDTLAQVLNLANIHAEAKYLVVDDTQGLVLSAVAERMGGYGKILGIHDGLNHNYDVLRYHNFSKRTLDSISTLPWTMVDKDEPTSEGYAEKSAEEVEALNERELINYERRKKTVDRIQSARDILYEGGFDALVIASQYSTMSILENLLPYIAGSRPIVIYSAHKEFLVEAFNEMKLSNDYLNVQLTESWLRQYQVLPGRTHPQMTTSGGGGYVLSAIRVLDEPTQVTEDGPEAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRG2</accession>
    <name>A0A8H7PRG2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_001679</name>
        <name evidence="5" type="ORF">INT43_008568</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRG2"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF21">
        <property type="entry name" value="EXPANSIN-LIKE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035141106" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="3">
        <location>
            <begin position="59"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2178833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2180986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="126" mass="12929" checksum="AFAA9696543891D2" modified="2022-01-19" version="1">MVSAKFITVLAIAATALAAPVEKRSYSGAATYYNPSAGTNSCGTQASDSDMMVALNAPQMANGANPNANPKCGKSMTVKGPKGSVTVTVLDTCPGCSNNDLDLSPAAFDKIADQAQGRVPITWEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRQ8</accession>
    <name>A0A8H7PRQ8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_002114</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRQ8"/>
    <dbReference type="OrthoDB" id="1926336at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF40">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00755">
        <property type="entry name" value="Grip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="3">
        <location>
            <begin position="639"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="590"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="73"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="318"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2179264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="688" mass="77700" checksum="5C0F84191B3DB0B9" modified="2022-01-19" version="1">MSSEGEAAGIERDPDLLEEYPENEDIKEKGVKTKQDCRSTGTALLISTKNEQRILEKDNVTPKLSNVELSDAADDTTSALLELKRQLEAEQASRAQSKLEWATLKKDLEAQLENLRTDSNDKETALKQLKVENSQLVEQIDKFTETTENYSKSSSEMKKDHLSKVQELEASIQSLKEKVDEKHGQVTGDVDSQSICNEMSSLRSQNEELSLQLTKQKDEVEKAHNDMKLMRQLQADSDERGKKYVAVLNKTKKQILKLEKEKSDATDEVAKLQSELMEIRELLSTAVQKEQDITAASSELQKTIQERDTAIADQCSKLRRQESELAILSKERKVANDSKMQAEDELQLKTAQYESSQIRVAHLEMRLKESEQQSEELYQRLSGLEEQLANSEQHVNRLKGNEEAFTKKSSGDLSTLQQLLDDVTKELTIERENAKQMKAANEKEQSEKLKRIEELQLELQSAQAQLEETNSILLERTTASNDSQSQVESLRSSLVAAENKIEYLSTSSTQISNELNQLKDWAGTIRSEKEEIERQLEESRMKETHFKSMNKVGIWIPQNLGCAGPFNLTPLHTNQKTLKDEIKRFTKVTPVSQASMSAASSRSASPSTKASSPSIMPNPPNIQNGQNGQADSHDSSLSQSISEVNLEYLKHIIMGFMENRQTRNQLIPVLSMLLKLNNEEIKRLQAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PS33</accession>
    <name>A0A8H7PS33_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pathogen-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_003469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PS33"/>
    <dbReference type="OrthoDB" id="65445at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053218">
        <property type="entry name" value="Pathogen-related_defense"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31723:SF10">
        <property type="entry name" value="PATHOGEN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31723">
        <property type="entry name" value="PATHOGENESIS-RELATED FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2178216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26909" checksum="01016D5D1AEE0142" modified="2022-01-19" version="1">MSLPDFMTNPNAVLSDTECEWRYGRVPDYNKVNAAFELEKTKDHKEGSLEWLVSNLVKNWEKEMSYKLRADQIRTINAEKYRFSVNGLQWHTVDEMLQMGTYNALIGDSELYKASETDFSDSHKLFKRALGTFSWEVLEVYSGPPTVAFKWRHWGKMTGDLSLKLGNGKKLEAPASNEVVESVGVTVAKVNEKFEIEELETFYDANILMKQLAKNRKDENGEQAVQSNGGKCPFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PS42</accession>
    <name>A0A8H7PS42_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_003484</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCDC90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PS42"/>
    <dbReference type="OrthoDB" id="889336at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000018">
        <property type="entry name" value="Mitochondrial protein FMP32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF1">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2178231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="271" mass="31139" checksum="EB143CACE08994E8" modified="2022-01-19" version="1">MTNSPDTVMFESSIYAASSQRFKFHMANCYTAGFNTRPLSQIAHNSASKDLIHKPSNQLSNLTTRLNTSVNIPRLFHTSPLVRDTGNNNTIAPYHFDTFKFVERLEKEGFNREQSEAIMTSMRTVIDESMANLSKTMVTKAEQEKTVYTYKVDFASLKSEIQLLEKNDFTMMRAENERLQGEIEKLRQRLREEITRTQANVRLDLNLEKGRIRDEASGQEIKIKETDTRIESEIAGLRTQMEAIKFQILQYMVGTITGAGALILAYLRMFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSM2</accession>
    <name>A0A8H7PSM2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_002005</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSM2"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001147">
        <property type="term" value="F:transcription termination site sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018838">
        <property type="entry name" value="ZGRF1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF531">
        <property type="entry name" value="PROTEIN ZGRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10382">
        <property type="entry name" value="ZGRF1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5'-3' DNA helicase ZGRF1-like N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="8">
        <location>
            <begin position="915"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="9">
        <location>
            <begin position="1009"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="177"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="370"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="451"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2179155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1233" mass="137148" checksum="9B95848BA39869F4" modified="2022-01-19" version="1">MSDQTYVQFVVLFTAQKLKKSKTWQDGVLKFYEFNKKMVLMDEKGYNIDRKFQKGKRPPQVGDEIEFDGHLVTVENVSDDNEDMSRSMESAVETASNFQDLRRRHAQQNAVTKLKAKWKPPTMMETPAVGHIKDESKMSNLEDYRREGREIPMQDVSNIQEPVEIKREEQIMTTFQHEMSDSRKAQVHSTLQLSTMSDPRSKADKRNADIQKNLGHEDSKRNQQSREHEKLSPLSSALNTTMHTKSCQQNNQFPATPIVTITQHPYNKSGFTLSPQPSPSGVDIAVNKASESTDQEMDGVEVDLGELNMEEENVNNTESENDVAAAINSTAEPVHIHEAMEANVQAAYTHRTSSNLPRYSSEDSIANEISSEVRQSDTVSSATVADTFESSGMKRPNTSIGNEEAPVVKRRIMVGLSKNKKASVAPRSSASMAASENLMSKSSFIKASEIQNMPSTTSANTDYARANSSNTNGPSPRILSTATNRTVSSTAHARSNAPVVPMVSSTSKGFSVPSIIIFPNASKLAQAAKTKKVNHRKLMVPTRFKSAPHYVETFTKLIQEHLQVLLQTYSIYFHSQVKDWCEVQTPLQFARSRGIGLHMEASLGSSSRYISGELDYCLTISNQQHRSKYGKDDIWVISKSLRFEPSGTFLARSTFYGPVGGSLVEIQCLTPRDGRIADSLCKTSKSLVALRTVSGSSEFMMLSALANGIDDCPLLPTILDHDDGTRRKRKQLHSTPNITSSDNGWIVLVASDGIDIESRLADTVKRFTLNEDQAKVLYATAGSVIKYPDWNRNENAAPVLLVHGVFGSGKSYLAAVLIIFIQELVDDINAGREPEERITYNVLITSITNVAVDRILLSLLDLGYDDFARVGSLRKIAKAILPYSVQSRVNNDADIKELEAMLKDEPMSANDTSFVETALQKFQKAETQANIREARVIGTTCVASVFELFNGTTVPLILLDEASQIMEPMAMVPITRFCAERMILIGDPLQLPPTLVTPCDPEIAGQGIEKTLFDRCAEMGISPVMLRTQYRCHPQISRLSNNLFYERRLINGLTEQKRPALFSDLPHVCFVNINGTEKRRPGYQSYHNDSEIRVTVQALRSLLLLGISPVDIGVISLYKEQADKLDGCLKEMTNSSFGSVQISTVDAFQGAEKEVIILCTVRTNPSNFIDNPQRINVALSRAKRHLIILGNHNALSRNALWSNIINLCKDTCLESEQLTGLLFQMTKARREPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PU47</accession>
    <name>A0A8H7PU47_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Formate dehydrogenase</fullName>
            <shortName evidence="5">FDH</shortName>
            <ecNumber evidence="2 5">1.17.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NAD-dependent formate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_003679</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="2 5"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PU47"/>
    <dbReference type="OrthoDB" id="418179at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042183">
        <property type="term" value="P:formate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05302">
        <property type="entry name" value="FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000057">
        <property type="entry name" value="Formate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03210">
        <property type="entry name" value="Formate_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033689">
        <property type="entry name" value="FDH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005750">
        <property type="entry name" value="PRK07574.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF9">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="7">
        <location>
            <begin position="34"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="8">
        <location>
            <begin position="127"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="172"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="228"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="304"/>
            <end position="307"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2179893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="358" mass="39423" checksum="0E906861403D5303" modified="2022-01-19" version="1">MKIVAVLYPGGDAAKEQPGLLGCVENELGLRQWLESQGHTYIVTHDKDGQDSELDRNLPDTDILISTPFHPAYLTPERFQKAKKLKLAVTSGVGSDHIHLDSAREHGVTVVECTGSNVVSVAETAVMSILVLIKNYIPAHQQIVEGGWKVSEIAKRAYDLEDKVVGTVGAGRIGFRILQRLKPFQCKKLLYFDYQQLAPELEKEVGVERVESFEDFLSQCDIITINCPLYDTTKGLFDEKALSKMKKGAYIVNTARGAIVDREALVKAVNSGHIAGYAGDVWDVQPAPQDHPWRTMPNNGMTPHYSGTTLDAQRRYAQGTKASEILEAFFQGNPFKPQDVIVHGGKVASASYGEKKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PV38</accession>
    <name>A0A8H7PV38_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003544</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PV38"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="124"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2179761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="191" mass="21769" checksum="71235A8A3E54176C" modified="2022-01-19" version="1">MTAPTIPPTTNSLKPEQIKELKSIFKSFDRNHDGTVSRDEMKKALTTVGVQPSDEQLDAMLPTGKPATFETFCEIMLPTYNDRLGEKNVDQELLEAFRAFDKDGNGVISASELKNMMRTLGDKVTDDEINNIMSEVDVNGDGVVNYEEFVMMMKPNSKRMNDGAEIKRRKEKSRKSFLKVKGWFHKLKREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVD8</accession>
    <name>A0A8H7PVD8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_008513</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1562405at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019415">
        <property type="entry name" value="FMP27_SW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019449">
        <property type="entry name" value="FMP27_WPPW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01215">
        <property type="entry name" value="Fmp27_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01216">
        <property type="entry name" value="Fmp27_WPPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMP27 SW motif-containing RBG unit" evidence="4">
        <location>
            <begin position="1283"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="3">
        <location>
            <begin position="1418"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 WPPW motif-containing RBG unit" evidence="5">
        <location>
            <begin position="1821"/>
            <end position="2336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="635"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1218"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1629"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1904"/>
            <end position="1936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2653"/>
            <end position="2694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2726"/>
            <end position="2769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2899"/>
            <end position="2920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2957"/>
            <end position="3021"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2002"/>
            <end position="2029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="648"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1225"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1259"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1640"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1662"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1904"/>
            <end position="1919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2653"/>
            <end position="2683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2726"/>
            <end position="2739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2741"/>
            <end position="2750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2899"/>
            <end position="2912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2964"/>
            <end position="2974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3006"/>
            <end position="3021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2180933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="3021" mass="339851" checksum="731D96BF28C4F092" modified="2022-01-19" version="1">MATWLTQVAIACLALIIARYTIHIVLALRYNFEYGHLGFLSISGITYHLRVWLDDNASRRSVTFKVGKVKLRLRHHFFQSRADNEQQSAFVTLHIQDVEIVVHDLALLRRQARQKQESEEEKARRGGSLASVGESLTRIPWWYSLSIVKWVIRTTSAIPAQLIISGLAQYADVRLERLQVKMENVATFEVENATLSSMLFADVKREHNGSSSPMTERDRLANPSVLLQEILINAQHQQHSFKKANHLWKEKFLEVNAAIGPIRVWHVPDDADSSICAALSFPALTHLALSCHLSAACTTLKDISLDVRLQSCDVDADAIIAILQSAKRQDPKIPTNTQAQPEESGNDSSYKRLSSGGLHRSGAIHAHRRAVSSENTVRGNQKAGTKLLLLKSTTFSISSVEISKRIYSSRSPLEDERLALAIDKASVGFVRDQCHQDEDLQPFPHSANMSTLGIEVYLLPSSEFKPASRIFSITQIEASLMASESVFLGKKQALTTQIVDTFATDHDHATEDPNTQLVKGSLNIMSPIISLDLQHMQSFNQIIDSFDKKNSHSKQQIGAKQIKWQIQNIPRFALSLSVNSPRLFITNLTVLNSGQNLFPAYTGITMQEIQISLRGNYVQVCEGANSPSLGSPIGSPLASPTHIPESFMSTMSPTSTSPPTTPTTAAQPPSTSRWKTLLRRSWRNVPKSPSLVTSKTWSFDTITSVRFIGCSPLLPELQENANQIPKPTLDNTLVFVDQIIASARTSVSSTIIAHHRRQPPTMCINIDNPQIEFCLSVNEPRINLWSKYNNLKQLDIFQNLMTSTLKVMNQSSPPHIEVTDTDKTVESFKLPLVFHNCNITFAIQNLTIGVIGTDAGLHGKRKIPEGYIDNAPLSDTYLGHVMYIESLSICYKFHGTSSDRSEAEAILEKPANESSLGAVDVFVNGAGLSPCVGLDSGQVLVLAGLAGERECFVHLSQVDARMVIRSRLEDGCFIVSPKVSVSFGRSLVFYTLQSHYATLLVILALKNSFLRSTSEPAQPKSTESKIKVELDKCKIALHHVDVRALLPGELNLFMRVRDLRFNLPMKNLTREIQVRSIRLFVISPQDTSSWDELIGIDNLSVVRQTEKNDNKLVISSSGVHVCIPFNFVVANIIDNALNAFKSLKLLTGRLFSEKYFDWRGPIPKDKPLHMAKIQLRFEILTFAIEDDPFEGRLRLIYRTGTLQQRTRLANEEAFMAKAQSVEEEQAQKDDQSGRRALDGEQVRDGFFNGSDNRPEEGASSYSTRNTNVPQEFGSGKSSISVNLAWNRLQEHNSNVWIRTIRNAEKEEEEAVKHQCESRRQHQHKIDHSFGQRALEFTSMYLSDLFDIKLINPPKHPSLLFAAMRCMDLTISPPEFPMEETRLFMQKIGDGIPLNTEFSTLVPFHLNWFADETWVQLRDYPLPLLYVPPSAKPDSGLWPRAWSLSGDYVFGDELGTKLATRTVNVTMLDIQNCHKYELTVPRTSTPPKFYSVVEIECLCSNPVRMSWATSMQPTIQDVSRTFELFTRPSVDPSEKLGFWDKLRLMIHTRTRIRFGGDFAVCLKGTRDPYNLLGKGAGFVKIWSKEVQWLIGYQNAQREFMQILSQEYILAVPDLVNGSYVVKHILPIQKDNSKKHRRQRSETSNGEMNIKSQLSGDMRKNRATESGTKPLFSSSAPEFQVSMPKGSRARTTSSTLSFKDGFERKDLQKIGLKLSGGVRWGVGCVIVQDTSRSSTSEAVNAVYLSPGFADHFLEWFRLFGGGMGLPTRAGPLFPKSDNRPSKKFGKHMSTVKYKIVTNHLSIGWFEKDEQSMYSVNGTGETLGLKASVSSFKFDLHQRRILTKIDSMKFGRERIKPHWLLNEAQVQVSDVDLRVIKAIYPNIGHSDESDSGRNTAAPSLVIDETSTLNSDTSQAFMSSSGSEDGDTYPHSETTAPDWVDPDDYVELDIRTPDFCPSVNVFPVMFSPSICYFKQTNRDDTERYQYLHETHECIFGSAQDTRATQVSLLKQRMEAIDVQIRNHQQRLEDVEHRLKKLPFESELLSESESIVEKTTVLFEKKSLLQRYLKSVLTQNMPDLPRTTAAGRSLLPENDPTDKWEALMGYFKQRCIVHNAQIIWNNSVRNLVYRLLDVHAQQRAHKYYMSMRAVKFLRDLTVNTKSNLNIKSPTLADGEADQALDMQMAKDLIDQLLSDQSNSSVPTAVDDTNDTSNEADVTLVNSNLNDPDYQRRGIPSGYEMKSSYIVELLNPQISLQSDKCPDAIVLLSTERTQLKGFNILDSSEDDLDTAVVKNRTLFSVDNIQFFVAKKAHFDTVDLLFDNHYGARGNEHWLTWIPLEMLINYTKRSDKFQRVADRATASMQYDTYNPLRLKTNQALFSRIHPLEERCDSVAVSFPSLLLTANSAQFNAIVDVVVDLLLYSEPARKERLERLQEIMMTVDMDNLMYATDTIIFLQNTIRQIATTQEQYRLSLAELTEQQVQEYKLIMTSLLHYKEELYLVMEALKKNPGGKQDSKDASQTKLKLNFSAEKIIWEMIIESDRTLCEWTLNNARYVWLSKEDHSSSNTLELDTIQCINRLPNPTFAEIISPYLEHRKQVDFSRHKMLRGYLHDLPPVGGIPVVQHLEINLFPLKFQMTQEFGKLLASYVFPVEKRKKSQQNSSISTPISTSSSAPNVASSTISIRSGSSDPPPHTLSITSMSDLRSNMGREFSPLSTSSEFASSDIHLEAARSDTLRPKRSDEHLNGSLTVGSPSKRSGIRKHYKNSSATSVPNADDLSVMKERASSNRTFIYIKVPGAKHCLSYQGPKEKNIEDLYDFVFTQPALEYRNRTWSWYELMNAVKKDILRAALKHSGQLLRDKLKIRRHPRGPPRLIPTSAPFATIATEPIYQKALAAASASEHLKPSTNSSISIATESSDGYDDQEDAVVNDTSSVDTTSDIIGDMEGIPQRKKHALFSGWARGSSKKAIKAPSPSATPISQAESEDSRGNFQTSEIQQKGKLLFGKSYSGFTRSSTPSHSRSTTNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PW19</accession>
    <name>A0A8H7PW19_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">40S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_004030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat AIP1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PW19"/>
    <dbReference type="OrthoDB" id="2306at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000118">
        <property type="entry name" value="40S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000102">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000167">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018277">
        <property type="entry name" value="Ribosomal_eS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856">
        <property type="entry name" value="WD-REPEATCONTAINING PROTEIN WDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00628">
        <property type="entry name" value="RIBOSOMAL_S19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="230"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="317"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="486"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="532"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2180241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="839" mass="91838" checksum="C60BB5A5431E53F8" modified="2022-01-19" version="1">MPFTQLHTFAPLPQTARGEAVKLNADPKGENFVYTNGKTVFIRNLENPALATAYTGHNNNATVAAYSPSGYYIASGDVAGNVRIWDTVGEEQMLKNEIKPISGRITDIAWDSESKRLIAVGEGKERFGHAFAMDTLSSIGEITGHSKVINAVAIRQERPFRAVTASDDMTVVFFHGVPYKFNKVIRDHTRFVQSVKFSPNGDLFSTAGGDGKVFLYDAKTGDKAHELTADQSHAGGIFAASWSPCSKYLLTSSADATAKIWDVEAKSVINTFEFGSGSSFEEQQVGNLWSGSNLLSVALSGEIRYLDKNSGKASRTIKGHSKAITSLTSTKDDTLFTGSYDGRVCSWSYGSEHDKTLPQPMEGEHHTNQVTSMVAEGDTLFSAGMDDVVRVAKANDKSYDGRSVSTAAVPKTVSVSNDQVLVVATSSNIQIYDKQQKKISQIDDLKFVPTTAGINSSGTHIVVGGEDGKSRVYKLVGGSLTLQQTLENNRGAISAVAINPQQNLVAVGDAVGKIYVYDMESGKSVVQAWIYHTARITNIEWSSCGNYAVSGSLDTNVYVWSREKPFKKSVVKNAHVDAVNDVQFLNEKDGKLTVASVGQDGALKIWAVDKCFRPVESTAIGQFSTSCKLHSTNDFSLLVTVSILLQLLISTTLSRFTNVVFFSAHRSPPDQLFPFRNFSNFTIGPDEFFFSKHETFPLNLEFVKAYAAYLKRTGKLEVPKWVDIVKTGTYKELAPYDPDWFYVHAGKTQYAVASVARHIYLRPSVGVGALRKVHGGRVNRGSRPSHHVKASGSVQRKVLQALEKVNVLEQDNKGGRRISQDGRRDLDRIAMTLIEQDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWM5</accession>
    <name>A0A8H7PWM5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWM5"/>
    <dbReference type="OrthoDB" id="5599753at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="2">
        <location>
            <begin position="218"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2180829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="301" mass="34424" checksum="D29FF131279490BC" modified="2022-01-19" version="1">MTSKAPYTATSNLAVQSPIAIHLDDPTTSKKDKKVYRYHEQSLPRSSSTLYNKSRDQIIVLTNSLDHGKAQHQRSPTLDQAQNIRHYELSTSAMDERQQDDIVSSHLVDDSLHPDRYFEPYITLDEKSAYGDPIVLPRSYIRPSPSPLSACSAQSSHLSSHLSTSYSKVRHQFFKSSSASSMSRLQKMGNGFRRQDIDTEKASTYARSDQNHSSQPQLHTRHSMMLPALPDFEVEAYCPECKKYVMTRIRYRSGTGVWLFSFVLLVLTIVFFWVPFYVKYFKGTYPGIHICPETQLKITLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWQ2</accession>
    <name>A0A8H7PWQ2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Actin cytoskeleton-regulatory complex protein pan1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_008707</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWQ2"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF173">
        <property type="entry name" value="ACTIN CYTOSKELETON-REGULATORY COMPLEX PROTEIN PAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EH" evidence="13">
        <location>
            <begin position="17"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="13">
        <location>
            <begin position="241"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="274"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="353"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="550"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="705"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="556"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="733"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="753"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="773"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="838"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="889"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="917"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2181125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="990" mass="110544" checksum="C1F63AE41EDA14FC" modified="2022-01-19" version="1" fragment="single">QYVISLGIRLSFLSSEDQSKYESLFAQATGNTGGRYVSATTAKNVLSRSGLSDDTLAKVWDLSAVTPSPQLSFPEFAIAMYLTSKALSGQAVPSLLSDDIVEEVQIAVATLESTNTANSSATQPQTAMATGMQQQYPMMTGVSTQPTGMLGNGSPGSLQPQMTGYQQMQRTGLQVPMMTGVTPMMVPNQQIPMPTGMNAHNLDFTSRMMPMPTGMYLANRRKEFQPLTGKVKIPWAVTDEERERYREIFKAWDKEKKGYLTGDMAKEIFSQSGLPQNVLMQIWNLADPNNQGKLNADEFAVGMHLIYRKINGYDVPTSLPEELVPPSSRELSDSVNELRKKIVNDIVHKKSTLSFSSSKSTPTTRSNPLSPNSPRGREKYKDDDSQVGYVSSARRAGPDRHRSRTPTSDGSSPNSRPSTPEYRGKTTRISDLRKQITAQNKKFEALIESGALKVATPFDSLSYSDRRDIEELQSRIKELQNEIVKSNVDQQNPTDVWGQYSYGTSELTSLSEQEKSLESEVQYLLEGTIPDLVSQLRDLDLEIIDKKKSLAKQRSGGESPTTNSSPIAVSTPDLEIVGTGPNGEVTESDKIRAKAKTMLAARMGKITGQKQAVSSSNSNESAQLIQEAEREKKVQDEKIAEFEGILHDLSDSIRGIRRDMNIIGLDFNARADDEVKLQEHSRFEDGEDVASHMRTFIREMSLETASARAPDVDPTFTSRFPSFEEQDTSSYHPSPPPSSSLSPPPTLYSSYSDKTLSPPAQSYQAPTSPKPRTAADIKKEAERRVQERMAALRIARGLSPSPAPPEDRIIDQSRSTKPQPDADERAAQKRLRAAQEAAQEKLRLAREHRAEVERQTQEKLKEAEEKAAKAAEDLEEMEKRISSETSLAQERERQRQMAKQLEDERRHHAVQTQDEAEVARIEEEARTAEAKRWQEGKQEQDRLERLRREKEDREAEQQRYKEEQDAIIKGARAAREAARRMEEEAAALSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWS5</accession>
    <name>A0A8H7PWS5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_006996</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NCF2/NOXA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWS5"/>
    <dbReference type="OrthoDB" id="9450131at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000017">
        <property type="entry name" value="NADPH oxidase regulator NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051864">
        <property type="entry name" value="NCF2_NOXA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175">
        <property type="entry name" value="NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175:SF0">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN C23A1.17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6 7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="9">
        <location>
            <begin position="444"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="366"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2182069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="544" mass="60947" checksum="2CF27050C1FDBCDD" modified="2022-01-19" version="1" fragment="single">FELEQWLRACDAYDREDYDQALKLFIGLADTAKMHFNIGLVLATIDDYPRALAAYSKAIELDQYFAVAYFQRGVAAFIIGDMELACSAFDEAFTAMRGNSIINYGQLGLAFHLYGCEVLFNRGICRLYNEQIEEGMKDLQLANAMRLNSEHDIIADALRDEGKGYSIFSIPSKVLYRPPKNRLNNMEMLAAAAEVHSDKNNGTRHNSVLMSTPRKHRLNFDLNFKSFMSKPSRNLVSRLLPSRSAGTEQLSERSLRDNFTTPSLLEAMPRASTSVPNIPQQNNRESTAFAVSRKKIKDDDFKQLQQEAIWKSLPSNPLSAATTPSVPPTPEDEQSLAMLSLEFPLPESTTNLVPELKSIEEVRKDSGFHSGHGENQSVSSNASAGDKTPKSETMFSQGEPLSQTNTTVSDLHDEDVMGYYESSGDVFTTYEALRDLQDGIDMNVRLKIKLHHDDMRILIVPATIAFSELAEKVKEKFDGKHVKLLFKDEDDELITMQDETDIMQARIAWQKRQEEAAGGASVKQSNPEKLDIWCQTVVASAPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWV8</accession>
    <name>A0A8H7PWV8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008529</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWV8"/>
    <dbReference type="OrthoDB" id="2328572at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="568"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="451"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2180949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="703" mass="80416" checksum="8BD1A8F1722ABDE8" modified="2022-01-19" version="1">MPVEWATLPTKKIICEACRKAKRRCSGSVPCERCIRNKIECNRVQHLNPEDLEYIQLFEEQRLTAEVQNLTEQLDNIQAVMQSVHDQQAADSADSTPIVSSDGQDESMSLFSGVEGSSLVSQSSISSTQPMDNFASLIKFANQTLQERSNQNELEDEKAKLELLKQSSADRATEWTLTMSKSGLTINTSIQTFADLIFHIPQLASIAISGVQFPMTEHVRQNPASLIVKRVPNPSFALRRSLLLAALKSIEAVRHRRMLNDNQYWISEERANELANKLVRTYFECLHYKRIVIHRKAFLDMFIKGKQNILSGGVCAFSAAIITMRCRHLLGIVSLADQEAVGEFFFNRAREAISETFDEVSLENYFTLLWMARYKVSMLEPEDAKKYIEMAERQSELLAPTYSLALDANHKQSPRDMGRTEMYRRLFLARREVNSAVSFLENKRGVPLTKSEHRVPHSSFDEKEREQRYSAPAKITPDDSILEKRGILRDRFMRMLEKGRQLGMKLRWAEIDQVSLKLIAEYEQRLKEWMTTDLAMSFYSAFLSLHEMLLPKLTDYARRSNNLFQHSEATEQDGDNESNMPPLNTPPNEHALRSQHVCSQAANLIVDLAKYQLEELGICNIEMAIFGIVWDVQLRNARLGQSIKDSNLSPMEKSMTITARQKLMSCVELVQQGYQLNSVEVDLRRFVAETADRIHIALAEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXC0</accession>
    <name>A0A8H7PXC0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Autophagy-related protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_007284</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXC0"/>
    <dbReference type="OrthoDB" id="338614at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01486">
        <property type="entry name" value="Apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000243">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006285">
        <property type="entry name" value="Atg7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01381">
        <property type="entry name" value="E1_like_apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="9">
        <location>
            <begin position="17"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="8">
        <location>
            <begin position="133"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606285-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2182354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="481" mass="53021" checksum="E9489D595F3B7CBD" modified="2022-01-19" version="1">MLNPSRSLYKSRILTASVQVIIGFVDPSGLAENPGWPLRNLLAHVNVRYGLQKLQVLCVRDQLSKNDLSLSLLLDIELPQGAGYTDNEHSIPKSVGWEKNSAGKLAPRLADLAPMMDPKKLADTAVDLNLKLMRWRLLPELELEKVQNTKCLLLGAGTLGCYVARSLLGWGIRKITFVDYGKVSFSNPVRQPLFEFEDCLNGGASKAEAAAASLRRIYPGVDATGFELAIPMPGHPITNDNQTAKDIERLADLIASHDVVYLLMDSRESRWLPTLLGAKMRKLVINAALGFDTYLVMRHGVRHDPQTPIDDSKFAHQLGCYYCNDIVAPADSLTDRTLDQQCTVTRPGLSAIASALAVELMVSVLHHKDGIYAQADAGTEPHIPSTESSPLGLVPHQIRGFLTHFNNMLISGRSYDRCTACSDKVIGKYEETGFEFLKNAFNEPEYLEEVTGLAQMKRESEALLETNDWVDDDTDSSEGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXL9</accession>
    <name>A0A8H7PXL9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Adenylyl cyclase-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_007089</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXL9"/>
    <dbReference type="OrthoDB" id="77251at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.330:FF:000001">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.330">
        <property type="entry name" value="Adenylate cyclase-associated CAP, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013992">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018106">
        <property type="entry name" value="CAP_CS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053950">
        <property type="entry name" value="CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21938">
        <property type="entry name" value="CAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01213">
        <property type="entry name" value="CAP_N-CM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101278">
        <property type="entry name" value="N-terminal domain of adenylylcyclase associated protein, CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01088">
        <property type="entry name" value="CAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="6">
        <location>
            <begin position="358"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="311"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2182162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="516" mass="54977" checksum="90B2CCB3D4C73B1C" modified="2022-01-19" version="1">MSEFHSLATLIKRLEVATTRLEDLALSGMSASTIAATNAPPAPAASASAPSEPTQVPRAVEEFSNAVDSPSKQYAELSQQLGGPVAEQAQLLQELVKAQRDFIHVASIAKKPDMSSPTFAKLVEPTQKALVAITDIKDKNRGHQQFNHLSAVAEGIPAFGWIAVEPTPAPYIQEMGNAAQFYSNRVVKEYKEKDPKQVDWTKAFLAIINELYAYVKEHHRTGLVWNANGESPEAAMSKITQSAGESQAPTATSSAPQPAPAPSAGGPPPPPPPPPVMTEFDEAPQKSAPAPATTGASAIFAELNKGESVTSGLKKVDKSQMTHKNPSLRAGSTVSEDSVKKQRPPTPSKPGKYVLKKPAVTELQGNKWVVEGHEGSNDITIEGEINHAVYIYGCKNSTIRIKGKVNAVTMDSCTKCGLAVDTIVSTVDLVNCKSFGLQIFNVTPTIVIDKCDGGQLYLSKTCLDVEVLTAKTSAVNILVPENDNEDAEFTELPVPEQLKSTIVNGKVVTTAVEHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PY60</accession>
    <name>A0A8H7PY60_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_007348</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PY60"/>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12418">
        <property type="entry name" value="RRM_Aly_REF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF35">
        <property type="entry name" value="RNA ANNEALING PROTEIN YRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="63"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="12"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2182418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="208" mass="22521" checksum="F3786EC75241CFB5" modified="2022-01-19" version="1">MSNDGALDMALDDVIVTNKPNRRGGRRGPSGGINKRNTGGSRGRNTPYSRPSANTRAMPARSNHLIVANLHYQVSEKDLYDLFGQIGRVKKAFIHLGPTGKSTGVADIIYDSPRDAEKALNAYNNIELDQRPMRITYSTSPAVLTAIAQTRLQPRAARGGNTRGGRGGRGGRGGRKPTAQPKKSQEELDAEMDNYMQAPPSEDTAMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYA7</accession>
    <name>A0A8H7PYA7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Membrane magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_006964</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane magnesium transporter (TC 1.A.67) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYA7"/>
    <dbReference type="OrthoDB" id="44756at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022890">
        <property type="term" value="F:inorganic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018937">
        <property type="entry name" value="MMgT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181:SF7">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10270">
        <property type="entry name" value="MMgT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034194865" description="Membrane magnesium transporter" evidence="9">
        <location>
            <begin position="24"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2182038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="14527" checksum="2B5C9A0BBF640351" modified="2022-01-19" version="1">MSQTLGRVLSLVGIAFLAHSAFSTYERKLSPTMVATSQYAANIQSTDLSYLNAVDKVESGLPIEITAECLMAVAVALVGIVLCSGDLKNILMENEMTKQTIDKLDTAPSFITFNHRGRRAVSAHTLLQRRSHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYE1</accession>
    <name>A0A8H7PYE1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYE1"/>
    <dbReference type="OrthoDB" id="2340857at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034915142" evidence="1">
        <location>
            <begin position="24"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2182083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="300" mass="32708" checksum="86473A505F7F9025" modified="2022-01-19" version="1">MKLLSVATSALVALGSIVSVVNADAYSDAMKEWCDGMSRTPNILTFPGIKITFPSTTTVVGAGSQTKVSVTRVPNQHEKSITGLDLYMVEGGSAKYINNIWHGMYSLNTQASITDTIPANTTAGLYYYRVWVTNMIQGQQGPACTPTSATFKVTSAGHTNDDGTTTQDDPNDTTLYNPEYQKGCFGLDVKYPAEGQTVDIGKHLRLQLHRDSASQTDELLQVDLFKGDPSNQGQFVQSIFTGEESINNILTLKDHIVLPSNVTSDGDFFYSLKVSSDKVDKTQDSCTFYSKNFKITESSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYM4</accession>
    <name>A0A8H7PYM4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYM4"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2182130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="120" mass="13455" checksum="F7087F454F93A51D" modified="2022-01-19" version="1">MVFNSYSRIENDTESLLDSVPSSVSPAPQQQRDRSMSSPPRPSFRPSNRNRAISDPYFGQSTSSKWQPLEDFGEEVTEGMYDEDDQEDLLVVSRPPLTRKKSSGLGLFKQNVLKAVGIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZM0</accession>
    <name>A0A8H7PZM0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Haloacid dehalogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZM0"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019120">
        <property type="term" value="F:hydrolase activity, acting on acid halide bonds, in C-halide compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006328">
        <property type="entry name" value="2-HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01428">
        <property type="entry name" value="HAD_type_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2182344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="28344" checksum="F33C1F0ABA55019A" modified="2022-01-19" version="1" fragment="single">RLCSISMLYRFCFDVFGTIVNWRVSMVKALDEYIPPESRPNVDSEVFVNRWRQGYMQAMARFSQQTFDQNNYPSLDDIHFETLESLLSEYKLQDMINDQNKVDLNMHWHQLMPWKDSPAGMAGLQNSAITATLSNGTVRLLVDLARYGDLRFDVIFSGESFLAFKPNPAMYQGAPRLLNLKPDEICMVAAHDIDLQYAKKNGLVTAFLYRPGEGHDEKEITTDLPHIDICITELTQLSDLYNKVKAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q066</accession>
    <name>A0A8H7Q066_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ras GTPase-activating-like protein IQGAP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_006489</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q066"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21206">
        <property type="entry name" value="CH_IQGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="67"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="557"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2183483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1216" mass="141541" checksum="F71CAFAA88723218" modified="2022-01-19" version="1">MTNRPTPLKRLSTMAGGKDLSDLRIPTITEDAEDVVGRIRLQKDEGTIITSHWMDKQRSNLQAYEYLCHIGEAKEWIEECLGEEIDPIVQLEESMRNGIVLAQLANWFAPGTVRRIFTESRLQFRHSDNINYFFKAIKLVRLPSIFWFELTDLYERKNIPKVIYCIHALSHLLARRNMAPNIKNLVGQLEFTNEEITATQRGLDRSGVAMPNFGNVRTSLRKELNEDDEDDDIHYEPIYMSKISEVMASPTTPDLIEESDSDEEREVEDEMTEEENSSLESDLYWSQPQNMANLIRCQSLARRYSARKEFNQVKDFHKSAWFESHMVKLQAQARGVLCRQALEDKRIMYEDAEGWITNLQSRARGFLARGRYQQRLDHYQANIDKIIKIQSFVKNKLVGDAYRKLTTASNPSVGTVKNFIHLLDDSELDFDQELSLEQLRQKVIRNIRDNGQLETHVNELDIQIALLLQNAITLDEVVGLSRKMNKKMQRRASQLAATTNNNPYSLRSLDKDSRRRLELFQQMFYLLQTEPKYLARLMYIMNGQESADHLGKKLVETTVLTLFGYAQNSREEYLMLKLFKYCIAEEMSYMENTQEFMRGNYIFMKLVVHYNRGAKERKFFRDLLQPLVNSVLEDDFMDLETDPVNIYHKSVNLEESRTGRPSARKHTASSQEALADAEVRDTFIQHLKRLREVTERFLSAIISTLDEMPYGVRFIAMELKKSLEENFPEEPKQNIVKIIGNFIYYRYLNPAIIAPEQYDVVETVITPMQRKNLAEVSKMLQQISSGKVFDANDLFLAPLNDYVFEAGQRFSQWFVALTDVEDAETHFGMDQFADFGNTHKPIVYISPYEVYHMHHIVSNNINDLEPEKAGPLRDILQELGQPLYSPNVEMPESAHTEMSLTLTNQYAKIPQDPNARLKQLLVDTKRFLLYVIKIQNGNDLQAIFTQPITNEHEHLWAELKQLEFQDREESQDVLQKRRYVHLGTAQDPPTDLMSLSFHQLKTITVKLVLNLERCGVISSGNNYQDLIKMIAKDITNKNTRRKIRQGEIQRLQQTLANLQEKTVYLEEQQKHYEGYLDSCMANMVSKRGKKNKFVLPFTRQYFHLRDLHRSGKVPKFGSYKYTAKQLYDRRILLELTNISPKQYDRIPLVISMDQVGIITIEGSYAGWGIASMSVELRFEELLQTQFNGIQTMTVMDGMAKVNVNLLIWLINRKFYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0B0</accession>
    <name>A0A8H7Q0B0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial import receptor subunit TOM20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Mitochondrial 20 kDa outer membrane protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Mitochondrial import receptor subunit tom20</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Translocase of outer membrane 20 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">INT43_006452</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0B0"/>
    <dbReference type="OrthoDB" id="2154253at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016031">
        <property type="term" value="P:tRNA import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.10:FF:000002">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.10">
        <property type="entry name" value="Mitochondrial outer membrane translocase complex, subunit Tom20 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002056">
        <property type="entry name" value="MAS20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023392">
        <property type="entry name" value="Tom20_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430:SF0">
        <property type="entry name" value="TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02064">
        <property type="entry name" value="MAS20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00351">
        <property type="entry name" value="OM20RECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47157">
        <property type="entry name" value="Mitochondrial import receptor subunit Tom20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="18">
        <location>
            <begin position="166"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="19">
        <location>
            <begin position="221"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG2183446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="483" mass="54861" checksum="803E358BEFBEE6A3" modified="2022-01-19" version="1">MKTKTVAIATLGTVAAIALGYALYFDQKRRNDPDFRKKLKREKKKIAKKAKQSADTIKQKVSETLEAGLEAVNQEEFPTSVDEKEKFFMSQISAGETLCAQGEEHYFEAAMCFFRAQKVYPSPVELIMIYQKTVPEPVFQLVVGMMTLEHQKRQDGFYKEFPPEDMNVKIEDIPEGTNGEGSTVMRKGLVVTKDFEEGDVIFVEEPIVSALNTKLEGGDFCNYCLKDITGDKVECANCDQVVFCSQECYEKANEEYHQYLCTNNKTNENAASSQEQAFLDYSKDKNVKYPYLIARFLATMVHDEIEKAKSGVTDGYGSWDHVDRFRYLELAPTDQNMKELKLIKELLGPKVTGVEEFLTEERFLMLKGKILFNAYSVQSIGKAEKAIEKSTELHRESQADLSSVGSALYRATTYLAHSCEPNSKIEFADKSHKLTVKATKPLKKGDELNTSYIQLEDKNTEQRRNQLAELFQFKCVCPKCESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0H0</accession>
    <name>A0A8H7Q0H0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_006542</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0H0"/>
    <dbReference type="OrthoDB" id="7827681at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000012">
        <property type="entry name" value="Voltage-dependent anion-selective channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0626">Porin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2183536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="283" mass="30205" checksum="FDCB7E0C930754AD" modified="2022-01-19" version="1">MSVPVPFNDIGKSSKDLLSKDFPVGSVKLEVKTTTPDGVTFKVNGQRDNKTGIILGDLESKYADKANGISFTEAWTTSNHLNGKVELENNLAKGLKIEVLTSLLPSVGQKTAKVNAIYKQPNVHTVASLDVFKTHFNINTVVGHEGFLAGGEVAYDVLDGKIARYNATLGYSAPEYAVTVHATNSLSVFSASYFHRVSSDVEAGGKAIWDSKGSNAVALEVGAKYQLDRTAFVKAKITNSGILGLGYTQLLRPGVKLSVGGSVDSTRLNENAHKLGLAFTLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q121</accession>
    <name>A0A8H7Q121_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q121"/>
    <dbReference type="OrthoDB" id="10313674at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="86" mass="9845" checksum="D16E8614C36BBA42" modified="2022-01-19" version="1">MNDSHWDVNGDEGFDDPMIEDTGYADQDEGWSRRGSRIILGDDHEDEERLSIQAEKIVHKGFFNSTLLSRDAPTHFTDDFDDKDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1H3</accession>
    <name>A0A8H7Q1H3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_006636</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1H3"/>
    <dbReference type="OrthoDB" id="277398at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00914">
        <property type="entry name" value="PCD_DCoH_subfamily_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00434">
        <property type="entry name" value="Pterin_4_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002018">
        <property type="entry name" value="PRK00823.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002020">
        <property type="entry name" value="PRK00823.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599:SF0">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="PCD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2183628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="123" mass="13967" checksum="D22EB4FF29FB9CD6" modified="2022-01-19" version="1">MLLGRSSTLRSTTSLYNIAFRRNMSKLSESARASLLKPLLDSQGWTMVSDRDAIKKSFVFGDFNEAFGFMSRVALRADKVDHHPEWFNVYNKVDITLSTHDCQGLSERDIDLAKFCDKVAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1U7</accession>
    <name>A0A8H7Q1U7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1U7"/>
    <dbReference type="OrthoDB" id="2397845at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="283" mass="32137" checksum="3DF4040F3C050DF8" modified="2022-01-19" version="1">MDSSRVVLPPISTLMNDVDQHHHHQRQRLDSARPLSKLTIETSPSIVVTDPRHASFHPPSPQSPVPCYEMKSPRPERYHRPTELLSPISTPVSPQSTSSESFSQLSSLPPPAQHHRSSWSPDTTQSSTLQIPNVRSHSRSYPSSPVDQEPINPFKRRASDQTSNFSFHMQQVKSSAITTPPRRRRGRPPNATEQNTEGPWTFLTPTVWDVGANNDKRDQDYYSVEPKATDHTVGILCDMSMDTMLTTPKRKRGRKPKHILEGNGCFVWKEIKSKRRSRKQPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2D1</accession>
    <name>A0A8H7Q2D1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_000465</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2D1"/>
    <dbReference type="OrthoDB" id="18577at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03496">
        <property type="entry name" value="SQR_TypeC_CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2184556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="132" mass="14181" checksum="AD29E3E0EB2046C7" modified="2022-01-19" version="1">MLSTIRYLLNCSLAAAVSQVGVSHTPDRVHGSYHWNVERAATVAMVPLVAAQLTVGASPITDALLGVVLPIHLHIGFDACIVDYLPARKFAVINKLATWTLNLATAGVLVGCYQFNMHDIGITELISRAWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2J8</accession>
    <name>A0A8H7Q2J8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2J8"/>
    <dbReference type="OrthoDB" id="440673at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="462" mass="49278" checksum="DB1FD745FCC96544" modified="2022-01-19" version="1">MRDASKQTKVTKTTSIDVATLFGNASSVQQTSVQTTDTRNVSLDQLFSNASLNAQPAPPVANPVGKSVNLAELFQTVNPPPKPQNVVPTPQNLSINDLFSRAAQQQSQQSNSMPMPMPMPVPMPVPMPAPMPNAPATSHGASPAVDPAVALLNTLRGGVMKTPDAQQHYSPQQAFQQQPQQPQQYQPQPQPQPLYQQPQQQQQQQPNPAMSLLDILKGAQPKREPAQEPAVTMQNNLQSAQQPVSNTPLPSQSPPVQQPTPQTNQSPTVLNGTRKPSTNSLLALLQGSNISKPNASGASTPQSQSMSPAMNAPSPTVKSASPQASTSKPSLLDTLMGAGPAKSPSIPPAPISTSPVRQTSSPSVQYDSMSPSRRSISGAPPLELNQAQELAHGQLAKRMQSVNVLSKPEFIQQFLNIIQSDATFLDTLYSDYVKQHPGTPSHQSAAQSPQYFGALYPGMSHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2P2</accession>
    <name>A0A8H7Q2P2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_006577</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2P2"/>
    <dbReference type="OrthoDB" id="636685at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23645">
        <property type="entry name" value="HFD_Dpb3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF54">
        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="28"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2183571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="192" mass="21259" checksum="CAB671B7E0275657" modified="2022-01-19" version="1">MQQASITPNAESPTPTTTKIDRTPGTTFLPIARVKRIIKEDKDVSLINAEATFCVAYATELFMEYLANEGFAKAKKEKRKTVYYKDLASVVNEVDQFEFLEDVIPQTMPLRAALERRREALDDAEYQGESNQSTRKGDQEETGATEMEATESADAYDDTTMAEEAAGEEPDVPDTEPSNGLGQESSSMIVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q425</accession>
    <name>A0A8H7Q425_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_000848</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q425"/>
    <dbReference type="OrthoDB" id="18234at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040185">
        <property type="entry name" value="Far11/STRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021819">
        <property type="entry name" value="Far11/STRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012486">
        <property type="entry name" value="Far11/STRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239:SF4">
        <property type="entry name" value="AT25231P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239">
        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11882">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07923">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01293">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01292">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Far11/STRP N-terminal" evidence="2">
        <location>
            <begin position="21"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Far11/STRP C-terminal" evidence="3">
        <location>
            <begin position="374"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2184935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="991" mass="113634" checksum="6FAEB28C967854E2" modified="2022-01-19" version="1">MNNQGDAQESNGGVENLRQFLQHENFVYGESDDMDIEINEFFNYNEVPGFREYQSLFDERKPEEWSSMNHLRKRDYIFHLLNDLEHSVQQVRLAAGKQLVYIAQGEFGDVEVLHCTGDDRVNHLKKIKDNNSLLQQCGALAIIYTVLRKACEEHDRQNNLSNLQDTNEEIGISLTIMFMLLETLRGGDSLFSDLEYTENLNPPLLVFLFGLMSQLREKNLKMFPVKKLLLVVWKAILASFGGQDDVDRIRTTIRKAFQLPAVKLNELQTKSSPQDLHTFAQEVVQKYPTYPGPSYPEHVEQPELIKPTAALSAMLGSNGNNQTNGSDVSKGHLGMGKIINIGQQSKRQSNALLGQNVQKEPFILPFSSWDMDVPKSIQEAGEMYSRHMYVSLATLQILKERERILRKSVLSNDEDGFEFILWFKEEMTDLESEDEDTTLTTDIKEAARRLNMKSIVPNLQNIIIVLLKLLLATVTANNGTSASNNNHYHENSPDRGGSSADGAETTHKIDADEIDAKRNKEITSKAVSAILLLLLRWTKLSRESSQHLEISHVLKYENVSQLLVDSGCLLLILKILGLQDMAVTLSEQSENQERNFFNYWSIQRRKRIHEDNVHEPIPDKPAMKYRHTNWRNMFWCINFLRIMQKLTKRKTHRIMLLVQYKSSVSYSQKIFKGIASNVGALHPQSTEKPGTLLGSKMEIKQVQFCMMAMAVVYVLISHLGNMRIITAIYLTCRPALREEWMTGLESESDVDESALQESNLRALIKAYHTRRYLPTIPPMQRRLESTNIVGNHMYDPTSSATGSSFLISSPLDDNEEVELDAAFMDNYEQWLEDEVYSMPSSPDVSATKSFTNDFLVSPSLSDSPIHQFYQDEERYAAARQINELYRSALDLEFNFDSTTKDNGWDAPVQIIRSYDPHPDDAHFDDDFEDSVNDPLSDIDWTALKEEELQARLLRIERQTIQRRLRTDDENDHKVLNAFEDLTIDNDEWDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4J1</accession>
    <name>A0A8H7Q4J1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_000455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4J1"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF18">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="8">
        <location>
            <begin position="57"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2184546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="310" mass="35181" checksum="E0D284E294F3F594" modified="2022-01-19" version="1">MAEPAQTRPRPTQQPVTSSAFRIMFSRMAIMAVVWLAVNVTRLFKAGKGVSPLTAETWPQFIADHPYQGKGPVENRSPCPMLNTLANHGIINNSGKDITKEEFIEALTKLNLGPQFGVFFVEGVFWMYHDKRSLPHWFGQLTTLDLAQLQKHNAIEHDVSYTRTDYDVENNAAADPKLVFQLSQFANETGYLDLASAGQARHLRQLQSIRDNTGLNFNLFYQFVGSGSECALLLNVLGRNMSISVDHLNTFFNEERFPDDWSPPEENFSAFKLAKATFQCYQSWKNSHVTLDREKEILAAYQKARLVKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4K3</accession>
    <name>A0A8H7Q4K3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4K3"/>
    <dbReference type="OrthoDB" id="3232309at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466:SF1">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="146"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2185696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="354" mass="41017" checksum="ADA5A780B25B70F2" modified="2022-01-19" version="1">MATNQAPPPSYASTLRRDLSRMLKKNHRNELPEVSLEDVLQEKTCSPISLQDFKWFLKNREHTLENLDFYYWYLDYRERFRSLSDLEKAKSPMPREKARPAASHTVTMDSAIGFGNENEERTAEELSSQNVDQTGTLGSDFQPYRDEINAVLKTFFDDSSFKELNLEQSLKKYVKYHACRTTHPEVFAEVFEHINWVLGHSSLPNFLHNAILNIRSGWVAIYYVSAFVHIIHVPMILYMTYTGHMSRLFRLPILFFAFGGISSFFTARIGFCTFRGLFKRRQIPLYELDDIQAARVSTEKYTRTNGAQNVTHLTTILDPNVRKHNIEMICHLMLFSLILAICITIPGLVITNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4P2</accession>
    <name>A0A8H7Q4P2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4P2"/>
    <dbReference type="OrthoDB" id="422005at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050181">
        <property type="entry name" value="Cold_shock_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11544">
        <property type="entry name" value="COLD SHOCK DOMAIN CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="8"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2185897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="205" mass="22160" checksum="003BE8FE5D804042" modified="2022-01-19" version="1" fragment="single">MTSTTNTRKSGRVKFFNSVKGFGFIIPDDQAGQQNIEELMARVFHHDQLEVFVHHTAIHNDGGFKSLAEVEYDLVQGPKGMQAANVSGPSGVSVQGDPNAGRRVFDPNYGGNRYGNNMAYGMTGGFNPGFTGQNLYPYGGGPFPGYSQQFPTFPYPQSGSPQQQVPSTSPSGMSSAHYSQQQQGAPFAPYQPQQMQQQTRGQPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4U3</accession>
    <name>A0A8H7Q4U3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein S5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_000972</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4U3"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03483">
        <property type="entry name" value="MutL_Trans_MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000109">
        <property type="entry name" value="Related to MLH1-DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="7">
        <location>
            <begin position="223"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2185059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="727" mass="81570" checksum="7357EAAEA42ACA55" modified="2022-01-19" version="1">MTTAVPSIRRLDQTVVNRIAAGEIIHRPANALKELIENSLDAGSTNIQVLVKDGGLKLLQIQDNGCGIRREDMAIVCERFTTSKIKSFDDLGSIATYGFRGEALASISHVAHVTITTKTEDSKCAFRASYSDGKLIPQKPGMSADPKPTAGNNGTQITAEDLFYNVPSRRKALKNPSDEYNRIIDVVTRYAIHNSGVSFSCKKQAANAADINTSTNNSIIDNIRLLYGSTVASELLLVEKEFADLEFKMKAYITNANYHVKKLTMLLFINRKYLYLWYRAVESSMLKKMIENVYITLLPKGSHPFIYLSLEINPQNVDVNVHPTKREVHFLNEDTLVEAIADAMQERLAGANDSRTFYTQILNVAQTLLPGAPSAESNESSQAPKPSGKINENKFVRTDSKLRTLDNFLQPSNASNSEKERNPEDVTMLEVDPAAENSSSSYASQAPVNRERIEVRLTSLLELRKEVKKNEHKGLSDIFANHTFVGIVDDALALIQYQTKLYMVNYAVLSEDFFYQLVLREFSNFGYINLSTPIPIKDFITVALDEEEAQNGWPDNMKPKAEIAQSITNILIDRADMLHEYFSLRISSKGELLSLPMLIKNYVPTMDKLPLFLLRLGTEVDWDSEKECFDSLAKELALFYSAEPPLREDEAPEELDQDHPMTGESSAQTSYEKEHKNYLWQVEHLIFPALKYQFVAPKSLAASSGPGSGHVVQLADLPDLYKIFERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5K4</accession>
    <name>A0A8H7Q5K4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SNRNP25 ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5K4"/>
    <dbReference type="OrthoDB" id="72819at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17058">
        <property type="entry name" value="Ubl_SNRNP25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039690">
        <property type="entry name" value="SNRNP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040610">
        <property type="entry name" value="SNRNP25_ubiquitin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14942">
        <property type="entry name" value="U11/U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 25 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14942:SF0">
        <property type="entry name" value="U11_U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 25 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18036">
        <property type="entry name" value="Ubiquitin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SNRNP25 ubiquitin-like" evidence="2">
        <location>
            <begin position="73"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2186221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="174" mass="20053" checksum="ED2D136716A9D573" modified="2022-01-19" version="1">MDLPTSVQKSEERSQPDMPRPSVDLTPSSTTESDHASIVESLLEDPLLNDLTPQVTLEEVKTLIAIEEGRAYRIRIERQRMDAIPLVVSQATTVRQMKKLIQAAFKRMVREQSSTRFVNWKYIWRTHCLVLNGNKLLDDSVAISSIGIKNNSSLSFEKYIARRENRRRNSRVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6H9</accession>
    <name>A0A8H7Q6H9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">60S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002427</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6H9"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_uL5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="7">
        <location>
            <begin position="56"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2185989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18916" checksum="388113DD1DB7B3D3" modified="2022-01-19" version="1">MRALRLEKLVLNICVGESGDRLTRAAKVLEQLTGQTPVYSKARYTVRTFGIRRNEKISVHVTVRGEKALEILERGLKVKEYELLTRNFSATGNFGFGIQEHIDLGIKYDPSIGIYGMDFFCVMGRPGNRVSRRRHAKKAIGVQHKVKTQETIEWYKSSFDGIVLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6I5</accession>
    <name>A0A8H7Q6I5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L37a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_002663</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6I5"/>
    <dbReference type="OrthoDB" id="2185952at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000002">
        <property type="entry name" value="60S ribosomal protein L37a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003058">
        <property type="entry name" value="PRK03976.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2186225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="10668" checksum="135227FBFE60CF77" modified="2022-01-19" version="1">MEQIQLNLLHSTVGVTGKYGTRYGASLRKQVKKMEITQHAKYTCTFCGKDAVKRTAVGIWECKGCKKVMAGGAWTVSTTAAATVRSAVRRLREMAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U6Q2</accession>
    <name>A0A8H7U6Q2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_008302</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U6Q2"/>
    <dbReference type="OrthoDB" id="195089at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026171">
        <property type="entry name" value="FANCI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029310">
        <property type="entry name" value="FANCI_HD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029312">
        <property type="entry name" value="FANCI_HD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029308">
        <property type="entry name" value="FANCI_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029315">
        <property type="entry name" value="FANCI_S2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21818">
        <property type="entry name" value="BC025462 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21818:SF0">
        <property type="entry name" value="FANCONI ANEMIA GROUP I PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14679">
        <property type="entry name" value="FANCI_HD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14680">
        <property type="entry name" value="FANCI_HD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14675">
        <property type="entry name" value="FANCI_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14676">
        <property type="entry name" value="FANCI_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FANCI solenoid 1" evidence="1">
        <location>
            <begin position="98"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI helical" evidence="3">
        <location>
            <begin position="298"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI solenoid 2" evidence="2">
        <location>
            <begin position="391"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI helical" evidence="4">
        <location>
            <begin position="567"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2171576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="744" mass="83722" checksum="2DFDCEA93244076A" modified="2022-01-19" version="1">MDSHILKLAKKPDHLELEQYLQQQGPDKITSLLGDILSAGQKYGSNNDTDPILVFRAVFIGSPIRPGDEESLERRLAAFMVALGWLINQVPDKNAPADEKVSSLANFLLPEIDSLPVDALRDVNSYIVEVIRKGDQFQSKIFDLIPKLLATAITHDTIEVEIDGKLQPLSGNEYVEYILDKIISCKWHPSYSVGMASAFNEMDCTGLQLQRITDKLLRQLNVLELNELPPLAYQLFLLSRKGEKQGIIAGICHHFQDAEEKMEIASGKSTNKHAAVDFNRVEGTIIVHMCFAIKQDQELGTEFLKYVKKHKSRALNSFTLACMLSMARIHRFEDTVLELLKSTILSVYKDAEKLEQYPWLKEAESLGLYKVSIKDMMDVVITKASSGWDQVTQSLVQLGVLLIDTSVSASPFKKPTVKSSTNSSPTEETCKLAIEILQKTFKLHDIVRQEIMTHILSRVVTRASSVMYFLDLLRLLVKDCPQILMEADNMSKIRETLDYLSFLPLSSAKQLLETLHPIIQRDNRLREALMLILRKGIFAKATEGRQIAVHGLLLILNSNGQQRGSSSTTASNATALEILGLLRRCFSQQPEIRQLVYENLSDIAEQRSDLTPDILSMLQTQFQKYYVTDRGIENPLLMDKCVEQSSTGGNVHIAEPIHSLIRSLTTTMTILKNHQSITSSSLSSLTGQIRSLCFRLSKSEPEDYELDKSSNYDMISNVGMRNKCRAQLLSGCYEVCYRSDGDMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U716</accession>
    <name>A0A8H7U716_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="35">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">NBP35</name>
        <name evidence="33" type="ORF">INT43_000108</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="33">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.</text>
    </comment>
    <comment type="function">
        <text evidence="27">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 27">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="27">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="24">In the C-terminal section; belongs to the AIR synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the N-terminal section; belongs to the GARS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="33">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2018833at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904564">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly scaffold complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000427">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000029">
        <property type="entry name" value="peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000009">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000006">
        <property type="entry name" value="Phosphoribosylamine--glycine ligase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000006">
        <property type="entry name" value="phosphoribosylamine--glycine ligase, chloroplastic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000001">
        <property type="entry name" value="Phosphoribosylformylglycinamidine cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000018">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.600.10:FF:000001">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000019">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="entry name" value="Phosphoribosylglycinamide synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03038">
        <property type="entry name" value="NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028601">
        <property type="entry name" value="NUBP1/Nbp35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520:SF12">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01209">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 27" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="16 27 29" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 27" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17 27" id="KW-0408">Iron</keyword>
    <keyword evidence="18 27" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="21" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0436">Ligase</keyword>
    <keyword evidence="20" id="KW-0464">Manganese</keyword>
    <keyword evidence="11 27" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13 27 29" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="19" id="KW-0697">Rotamase</keyword>
    <keyword evidence="15 28" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="32">
        <location>
            <begin position="419"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="31">
        <location>
            <begin position="1094"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="28">
        <location>
            <begin position="1295"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="28">
        <location>
            <begin position="1389"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <begin position="70"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00010898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00029388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00029444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00049057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="KAG2172761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="35">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1452" mass="156914" checksum="75CEDD09721D12D4" modified="2022-01-19" version="1">MAPRSTDTVPQDAPEHCPGTESDQAGKADACAGCPNQNVCATTPKGPDPDIPHITKRMSTVKHKLLVLSGKGGVGKSSFTAQLAYALAHDDTQVGVMDVDICGPSIPTIMGLEGEQIHQTGSGWQPVFVQDNLAVMSIGFMLPDKDDAVIWRGPKKNGLIKQFLRDVDWQDLDFLLVDTPPGTSDEHLSVAQYLKESGIDGAIIITTPQEVALQDVRKEIDFCRKVKIPIVGVVENMSGFVCPNCKGESTIFPPTTGGAEKMAKEMDVKFLGRIPLDPRIAKSCDMGVSFLDEYPESPACDAYDHVIDHKLNILLVGAGGREHAIAWKLAQSPLVEKIFVAPGNGGTTAEEKLTSVDIGVSDFAKLTEFAVNNNVNFVVAGPEQPLVDGIQPAFKKIGIPVFGPSIKAAAMEGSKTFSKDFMKKHNIPTAAFENFTDFEKAKKYVETVGHRVVLKASGLAAGKGVLIPETTEEAVEGLKSIMVNKEFGSAGDEVVVEEYLEGEELSFLAFSDGYTVISLPPAQDHKRALDGDLGPNTGGMGCYAPTPIGTQDLIDEVKRTILQPTIDGMRRDGYPFVGMLFTGIMLTSTGPKVLEYNVRFGDPETEVVLPLLSDDTDLAEVMFACAEGRLDAVHIGIKNAYAATVVIASGGYPGSYEKGKEITIGNVPQDVMVFHAGTAMKNNKLVTAGGRVLAVSAVASTLREAVDKAYEGVNIIKFDDMYYRKDIAHRAFKHTEKKDTGISYASAGVSIDAGNLLVQKIKSLVKSTKRVGADSEIGGFGGIFDLKAAGYRDPILVSATDGIGTKLKIAHDCNIHNTVGIDLVAMNVNDLIVQGAEPLFFLDYFACGKLEVDVAKDFVAGVVEGCLQSGAALVGGETAEMPGLYAPGDYDAAGFTTGAVDRENILPRMDQIKSGDVLLGLSSSGVHSNGFSLVRKIVGTQPGLTYHSPCPWDKSTTLGKALLTPTRIYVKQLLPVVRKDLVKAMAHITGGGFIDNIPRVLPEHLGVQIDATSWPLPPVFKWLKAAGNVSAYELSRTFNCGIGMVLVADRSAVPEITRLLAEANEQVFEIGQLVEKSALNGEEVVVNNTEQAWFFDIEIGGEPEGRIVFELFKDVVPKTAENFRALCTGEKGIGKAGKPLHFKGSIFHRVIKNFMCQGGDFTNFNGTGGESIYGEKFEDENFDLKHEKPFLLSMANAGPGTNGSQFFITTTETPHLDGKHVVYGKVLKGKGIVRTIENQPTSSDKPLKDVVIVDCGELAEGEDDGIPVPADGDKYEEFPDDYEGSKEPADLAKIASELKAIGNDYFKKGEYQSAAKKYQKAIRYLQEKPVFDEDEDPEELRVQFYSIKVPCYLNRAMSQLKLGNYKSVIEDTTTVLEFPEKYLTPSDKAKALFRRGSAYIQNKNEAEAIADFEQAAVHNPSDAGIKQQLALAKQKIAQRKQKEKAAYSKMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U726</accession>
    <name>A0A8H7U726_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_000231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U726"/>
    <dbReference type="OrthoDB" id="2430343at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140580">
        <property type="term" value="F:mitochondrion autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013898">
        <property type="entry name" value="Atg43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699:SF1">
        <property type="entry name" value="MITOPHAGY RECEPTOR ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2172881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="160" mass="18258" checksum="3746D8E4E7CE0ADA" modified="2022-01-19" version="1">MTSGFSAEQMDPLILDEEEYIEYLRAQRRAHMAPEGGRFGNLDEDDSDQAPHMPPIPDMRFEKQINRSIEVLQAKNASALHIFLSVVLKDQIVMPFLNGFFWGIGAHAVRWYRYRPKHGTSESHGNGYWRRLGHKINTSIGNIYHSVVHLPSLTGRPASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7D7</accession>
    <name>A0A8H7U7D7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_002927</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7D7"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001166">
        <property type="entry name" value="ADP-ribosylation factor D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="62"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2171305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="116" mass="12786" checksum="8D7A49E6BECB536E" modified="2022-01-19" version="1">MWDIGGQESLRTSWKTYYTNTKAVIMVVDSSDTDRLHIAKRELHQMVESESLSEASVLIFANKQDVKGALSSAKVSEALGLTTLKDRQWHIQACSALTGDGLYDGLDWIVAQIGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7U1</accession>
    <name>A0A8H7U7U1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_005878</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit APL3 and beta-type subunit APL1), a medium chain (mu-type subunit APM4) and a small adaptin (sigma-type subunit APS2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7U1"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14833">
        <property type="entry name" value="AP2_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000011">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027156">
        <property type="entry name" value="APS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="24"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2174816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="166" mass="19449" checksum="BAFF099E5D18F0F1" modified="2022-01-19" version="1" fragment="single">LILTLPLPLTLTLTSSPPPIHHTQIRFILVQNRQGKTRLAKWYVPYEDDEKAKLKGEVHRLIAPRDQKHQSNFVEFRNYKIVYRRYAGLFFCVCVDANDNELAYLEAIHFFVEVLDAFFGNVCELDLVFNFYKVYSILDEVFLAGEIEETSKNIVLTRLDHLDKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U873</accession>
    <name>A0A8H7U873_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase PEP5</fullName>
            <ecNumber evidence="9">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_001123</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex. Component of the class C core vacuole/endosome tethering (CORVET) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the VPS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="9"/>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U873"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16688">
        <property type="entry name" value="RING-H2_Vps11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016528">
        <property type="entry name" value="VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024763">
        <property type="entry name" value="VPS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12451">
        <property type="entry name" value="VPS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17122">
        <property type="entry name" value="zf-C3H2C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007860">
        <property type="entry name" value="VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="11">
        <location>
            <begin position="425"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="955"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="743"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="912"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2175476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1044" mass="117755" checksum="12D2E1E47BF4AC2B" modified="2022-01-19" version="1">MAHVQWRQFAFFDRSSVADSSDPSKTPEAFQSSNTTVFTSGRGHIILADILFEHREFNSKSFLAYDGGRVTHLKHLKQSNIIVTIGESDQTNQPPVIKFWDFEKIDLTKNIDGGILAPPCTRIIKIQHGGMVYPVSTFAVLENLTQIAVGLANGTVILIRGDLQKERSTKQKVIHEGSEPITGLGFREQTKSTILFMVTTGSIMSYNTTASKPTTTTLDDQGCGLECAVMNDNQDMILGRDEASADYYCIFAIYQYDNTGRGPCFAYESPKTSLKWFKSTYLIITSPPLSSTVPSYRPGSSGTANINFTRQPGQQISSSDLTKLTIFDTANKFVAYKDSFIGGIRGVVCEWGAIWIFGLDNKIYRLDEKDTPSKLEILFKQNLYVLAINLAHMQNYDDASIVEIFKKYGDHLYVKGDYDGAMEQYIRTIGKLEPSYVIRKFLDAQRIYNLTSYLQELHSRGLANADHTTLLLNCYTKLKDVSRLDEFIKNDADLTFDLETAITVCRQAGYFEHAVYLAERFEEHDLYLNIMLLDMHNYQAALAYIAKLGPSEADKNLQKYSKILLKHMPQQTTRILIRLCTGTLPPASSTSPPPLPLRPTSPTSSIVNNTASALQALSLLPFSGGATVEDSASAKHQVITAGGKKSDKVTKHAFASYAPPSAQTYMPSFVDHPDYLIQFLEEVYEKRTASAREKVMISESASVRSYPAKEEVPVELNPQDAEEQKVLWTALLELYLMDERPINTSLDDSDDSDVEQTTANDSNDQMDKEIARRRKLRSKALALLKDKSVDYDANQALVLCHLKQFDDGVVLLYEKMEMYSDIIRFWMEKEETDKVIECARKFGPTDPSLYPLVLTYFSSSSETLKKSTSELLSVLDHIDAQDLLPPLQVVKALSRNDVASLALVKNYMGRKIEKERKDMERDSALIKSYREESERRREEIEELQTSARVFQVTKCSACGGMLELPTVHFLCRHSYHQRCLTENEKECPQCAVQHRMIADMRRTQEANADKHDLFYAQLEDAEDGFSVIADYFSKNTMAFAKLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9B0</accession>
    <name>A0A8H7U9B0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">6-methylsalicylate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_004556</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>6-methylsalicylate + H(+) = 3-methylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:23112"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17231"/>
            <dbReference type="ChEBI" id="CHEBI:36658"/>
            <dbReference type="EC" id="4.1.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:23113"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.52" evidence="7"/>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9B0"/>
    <dbReference type="OrthoDB" id="191270at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047596">
        <property type="term" value="F:6-methylsalicylate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF29">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="5"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2173182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="323" mass="35846" checksum="5C911D957423E3AE" modified="2022-01-19" version="1">MANRIDTHFHIVPDFFAQAIEETGGDPSGWKTPSWSVEQAKDHMKTLGIKKAFTSITAPGTSIYITDTKKARDLARQCNEFAAKMRDDDPDKFGFFATLPPMIDVEGCLAEIDYAFNTLGADGVTVLTSYQKDGQGVYLGNELYYPIWEKLDVMKAVVFIHPTNSSVPQVNKHAAQPIFDFPQETTRTVGDLVLSGTKGKFPNMKMILSHAGGTIPFLAYRIMGVGSPSRSQQDVAKDFKSFWYDTALSTSKAQLLALLEIADPNRILFGSDIPYAPFEAVKVVTNGLDTFFAGDEEQQELLRKINYKNAQALFPNELGLHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9H8</accession>
    <name>A0A8H7U9H8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA-binding protein vts1-like alpha-helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007978</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9H8"/>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA-binding protein vts1-like alpha-helical" evidence="3">
        <location>
            <begin position="15"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2177321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="176" mass="19552" checksum="B9B9124CD30655E1" modified="2022-01-19" version="1" fragment="single">MANASFDPNFKEELGHVDQWYRALTEAERTAAVYSLLQHSSPVQLRFFATLLQQMNAQDQLGAMLSPAHPEKGKSSCMHFTLLLLSSTRRTNHVPKPGDLQAQMVGAMAKAEKEASQKLLSVLPYQTGQVTRRPPDSLQGPRRALDRHSFAIGDTEEYKGLFPVGSDFLSPHPSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9N6</accession>
    <name>A0A8H7U9N6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9N6"/>
    <dbReference type="OrthoDB" id="2284923at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034218443" description="Reverse transcriptase domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="940" mass="106151" checksum="E1F2930CFE33302D" modified="2022-01-19" version="1" fragment="single">KPICKPLCRLLLPLFQLCWTWSYTPPGWRHAQVCPIFKKGDPTLASNYRPISLTSILRKAMEYCLAPALSAESPELDLAQGGFRPQRSAMDQALCLHELMHMQRQRQHRPTVVAFLDIKSAYDTVDRNIIWQTLASHGTNTGLLSLIKHLFDDVTTSVLLSNQTSAPSSPATGVLQGSVLSPYLYSIYINSLPEALRAVVSPNSIRVADPPTVINSLLFADDVAILGSVADVQRMLDIAAAHSHLLGYRWSPTKCATLNSPRPLTLYGEELQSVEEFVYLGLPFRKNGLSASSLIEHRTKGTRLAMATLQAIGARPSGFHPLLSARLYRQFIRPKFEYGLAISALTKTDVKNLNRLQDRCLRAITGGHPTSTVHPFRHMTDTPTMGARALTLTLKFGVRLTYLPDDCLISLLSPVLLPCCRLPLLRLNPLYTALPDPPPLDLKDTILEYRQGELELFRESHILVRGCRPTIGIDPVLLVPATRRERSRLLRWRLGWLPGKPRACLCGTDRSSRRHLMECPMLPQHLWLQLPYPSDGSNHLDFAISQIPASLHTPPAYWPALHTLLFLIDQMCLQEGTLPPEPNPGSSWVTHHHNFHLYNEILPNVEYFTYLGVPFGPKGMEPQRPIELKAPKTVAAMQVLKSLGVHGAGLGEMLSAKLYRQFIRPKMEYGLAISKFLVTQAKSIDGAQDKCLRMIFRRRNTTSTSVFRHLTDLPDMQTRILTLRAKFAIRAETLPPDTLFCLLIPKMHSKHSRWRYIQKVNPIFDRWDTDRTIKLKDIIEQWRQDQHDRLCLVRARNAVCRPLIGPDPILALPAIRKERSRLLRWRLGWLPAQPLACPCGTHLTKKLCFQQCPAIPDNLWPELPAPDTQQTMSTIDFTLNQLPVAALKPGYRPSAQLRKWWPVLLELLRYIDMFCHADSPFIDEPPAGALLLATPTPDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UA39</accession>
    <name>A0A8H7UA39_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UA39"/>
    <dbReference type="OrthoDB" id="2289567at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034559142" evidence="2">
        <location>
            <begin position="25"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="764"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2172089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="790" mass="86529" checksum="203BEA2DB11B62CF" modified="2022-01-19" version="1">MKFGTSKLLISAAVAVAFPSLSTAAPFFSSSTSSHSNDATNESVENCQDFRITYPAASGLSWTDGSNHVLAWQATSDATSVDISLVDEQNETVSQLGSYDASKGATGEKPISLQGHPTGFYHFEFTVKSASSQCKLSSEKVQINGSSDSTSHSNAPPSDEDLDQIFDSLSNGHANQEWTSESHDDDASPASVAGVTPSWTSHEDDVQENAWHEDDVSDLVDALGNHPNADGWTSHDDDVQENAWHEDDVNDLVDALGNHPNADGWTSHEDDAQENAWHEDDVNDLVDALGNHPNADGWTSHEDDVQDNAWHEDDVNDLVDGLGNHPNSEWTSHDDDVETKTDSTEPKNFDELIDSLDQPYDQYLENNNATEGQNLNVHKNEADDTESSGADPTTTPNGDLDSTLDDIFAKLAGAGSTGSTSHDNAAPVDDHHWHSDDATFFTDELHEAEPATDASHSNDTEWQEEDDDTAPATHSSDKHWHSDDNTYFTDEVGDGATTQTNDSADHSNAAEWHEDDVTVEDTGAAASEPAGKFWHSDDANYFTDELQGDQTQTSSSSAPHENAADWHEDVAEGWNGDGVAHVDEAPVDDSPDRWFTDVQNEENHTNEDIEGLVDNLSNEHADDSAKWFTDVHNEENHANEAVEEPASTEHADDSAKWFTDVHNEENHANEAVEEPASTEHADDSAKWFTDVHNEENHANEAVEEPVSTEHADDSAKWFTDVHNEENHVNEDIEGLVDNLSNTHADDASPDARWFTDVHNEENHANQAVEVPAAAEEHANDADKWFTDEHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UA96</accession>
    <name>A0A8H7UA96_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Polo kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_001122</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UA96"/>
    <dbReference type="OrthoDB" id="408964at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="136"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="9">
        <location>
            <begin position="671"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="9">
        <location>
            <begin position="778"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="490"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="547"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="555"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2175475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="862" mass="98452" checksum="206E863E127AA8EA" modified="2022-01-19" version="1">MSSRMPINDSSGRNKDIHNTTKPRRYQQLGQADKALVDIPANLLPTNYNPAGQENVDQPKLPKRQYHGIVSEKAPLRAKAAVLGNADKNIINNEVQLKPQQPQKAATSESKYIIPDNIYDKKTGETYKKMRYFGESMADDNMPQGGFAICYEAENSRQQRFALKVVAKRSLRDHKLKTKFLAEINIHRSLKHPGIVRFHNCFEDSQNAYLVLELCENYTLARMLKERHRLTEPEARYFLIQLLDICRYLHESKVIHRDIKANNILLDYKMDAKLSDFGLAAILVNAEERKRTICGTPNYMAPEILYGKTGHNQQADIWSLGVLFYTMIIGTPPFHESSHDAIYQNNRIMPSYTFPEDIRISDNAKEVISSLLVNDPGTFAIQGDVSMWGYIELTNILILSEKRPSIKKLLSFPFFKEDFLPAAIPVCALKRPPTELDFARYANASKAVTSPDNAAAALQRASQRDEIYARKPRAPLENLELLSERLTDPRQMLRTQSSRDNWNISNVPSSTFSETERHSKRSRTQYAEEYDVSPGNVASKIQALESKAAEQLSPSRSTSASTVTKKTTLISPQERLSSKSPLPRSNLAVPRVSKSPKPQETEHLLQRLRHTTTSLKPALPVDSYVYNDIENVVQYMYEALENVLSSKHRVQTIRKIRQRADEESKVSAVVFIDRWVDFTHKYGLGYCLSDGSNGVYFNDATTLVTKVDTDHVSFVCNLSEDAPDYVKPETFRVTRYPHTYRKKMTLLHHYQKYMYANLMPIAKSLPANHKAHNQQAIYLENYMQTDRAAIFLLSNNIIQINFWDHTKLVLCDTESIIYVNSSREWSVRSLVASDLDDEVLSRLEYAHEVLHPDNRAPLTTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAS6</accession>
    <name>A0A8H7UAS6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lipoyl synthase</fullName>
            <ecNumber evidence="3">2.8.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_005755</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAS6"/>
    <dbReference type="OrthoDB" id="3231at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000036">
        <property type="entry name" value="Lipoyl synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="124"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2174697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="387" mass="43282" checksum="14F5D28353FCC2BB" modified="2022-01-19" version="1" fragment="single">TQLRTHATTVSDKPSPPSTSQSAKSKLSSFKEKLQAETSALGDFINQGDDKLTAEEALELKTTVTDNHKGKKLKQPRLPSWLKTDIPVGQNFSRIKKDLRGLNLHTVCEEARCPNIGDCWGGGEHNTATATIMLMGDECTRGCRFCSVKTNRNPAPLDPHEPEHTAEAIRRWGLDYVVLTSVDRDDLKDGGSAHFADTIRRIKQKAPHIYVECLTGDFGGSLESVAAVAESGLDVYAHNIETVEELTPYVRDRRANFRQSLRVLEQAKKTRPDLITKTSIMLGCGETDEEVQHALEELRKVDVDCVTLGQYMRPTKRHMKVHEYVTPEKFDMWHQKGMNMGFKYVASGPLVRSSYKAGEFYISNILNQRKGLPVKDIAQAEETVKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAT5</accession>
    <name>A0A8H7UAT5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_000204</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAT5"/>
    <dbReference type="OrthoDB" id="1725934at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="3">
        <location>
            <begin position="230"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2172854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="400" mass="45165" checksum="18573277DFB2CBB0" modified="2022-01-19" version="1">MGAWISRQKKTDDGDYEKILSELDSKLQTAELKLSEIKIRERRINVMFVLYGFALWAVYLAYCFATLHNAEVEAQTYAIKIAPVVLIPVILYFGRRGLKWFYTRKQTNEESNVASLRAQQKLKVEELKKKTAYYTTKSLLERYDESSRQKAKQPAPGAARPAQGATPLKKNANERDPNFGHKPSPMIQNNPLLHKQPQPNMNMNMNMHQPGHPNMQPPNMRPTQPAQREWYDKLVDAIVGEEGPETKYALICNHCSTHNGLVLPQEIETIQYVCPKCGQFNPSRRSRQLHPGGPVLPPGISPAQSRSTSPKEVRSLSQNRSGPRGVSQTRDSSEDAQRRGRSTSSRRVPASSKARDEDQDNFIQEQVPEADSSASGDSDTIASRVRLRKRPTSEELEVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBV7</accession>
    <name>A0A8H7UBV7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003642</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBV7"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658:SF18">
        <property type="entry name" value="PROTEIN GAT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="6">
        <location>
            <begin position="273"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="247"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2179856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="409" mass="45247" checksum="C392AEF6299B9CF3" modified="2022-01-19" version="1">MNVLRSHDGHHSNGHMYSKSTGASQRIFQILDNRSKRLLVSWPDGYDDNQSSSSAYQKLITSSLFDTKSKSDTAMKSLDTLQDSGLTCIQKTCINSCTSYLCGTMLKTVERVLITYGNIVFGLFRLSDSKSAISPTVQDESTRIPSISTITMSIPNTKSISSTTVNLSKQSTISLNNHTETTCTESHPVKNPSATRNNQIPETSKAVVTGKEVMSTQISNLQPDYTHSNLLIPYARRMCNLPELSPISESPNTRNFASRPSESYFRSNQPKNPSSIHSCESCATDSSPEWRRGPSGHKTLCNACGLRYARSLARQTKAIQQQETLNGESATIEDQISTQKRPLSEPHPPLLPPPYFRQQTHHTLSLVTNQPFPPKLSTLSNLGDASVQQLPSRARENSDTPEHFAPVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UC23</accession>
    <name>A0A8H7UC23_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_004421</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UC23"/>
    <dbReference type="OrthoDB" id="431497at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="820"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2174398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="879" mass="97940" checksum="AA5D1A033EE94D64" modified="2022-01-19" version="1">MPGESTPILHHKRRRTTGTDYQSTADDSARPSRQGSRIEPSRHSSFHFMKRRTGAYDEDSQGLIDENTGVRVWYENYSSIGKDKAMTNKNMRIFRHPLTKENLFPSPPDWIHDHIKEKLRRRKIRSMRGMRGYMKNAFDGAKAWILVTITGLITAILAWLIDLVQELFTDWKDGFCVAKWRYNRKFCCWGKEEYEACPAWQSWPEILDVSSHEESYYTAMGMYWLFGLVFCGVATLLVKYSAERVTSRVPAVEPKHRSFSRSTSALLEPEIGAQRQTTSKVASSPLIVQKTKMAYYCAGSGIPEVKVILGGFVIKGFLGIKTLFVKSVGLVLSTSSGLNCGKEGPFVHIACCVGNIACRLFSKFNKNEGKRREILSASAAAGVAVAFGAPIGGVLFSLEEVSYYFPIKTMIRSYFCALVAAMSLKMLNPFGTGKIVMFQVQYDKEYHVFELFGFILCGIFGGLFGALFSYCNAKYQRLRKTTFIGKYPIIEALGTITLTVLISFWSPYARMSLTEFVTNLFSECSSLDDNEGLCAKRASEIPPLVYLLLSTLVIKLFLSIITFGIRVPGGVFLPALAIGAIFGRAIGLVMQYLTLSYPEHWIFAACPADIETHGRCVIPGVYAIVGAAASLAGVTRTTVSLVVIMFELTHSLTYAVPIMAGVMIAKWAADAFFPAGIYDLIVDLQEYPYLESKREYIHTSGVPELTEYLETLNSDTAITVDDLHAAIERLEALGYAEDGGFPILTEGNILHGYIACSELIHAIEEVSKRVQPGEEGKVKCYFKRNDEIVSTPHSLDTSGSAIFTENGTEMQRLGDFSKYVDQAPLTINQHASVELVMEIFIKLGVRYVCVAGASGKYHGIIHKRRLLSYLKELEEEGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDB0</accession>
    <name>A0A8H7UDB0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Noc2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_001606</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDB0"/>
    <dbReference type="OrthoDB" id="10266662at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF4">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2178760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="690" mass="78283" checksum="6E8806BB519D25D5" modified="2022-01-19" version="1" fragment="single">KSQEKSFNDMSVEDFFQGGFEDQGASSNDDEEDDEFSALETVETAPASDSDEDAVAADSDDQMDEILDEEEDDEELFDDEESDEPKPKQKGKKASLKSDISKHKEELEKLKEQDPEFYKFLQKEESGLLDFDVSDEDLEDGSDEEGLGAQQDEADEESAFADEADVDQEDFDEPLGSQANDGEAQVVTKQMIEDWAEAIETTKSVKTLKHLLSAFKCAARMNDEDDETTTYAYKVTSGSVFNKLILTTLRLTPVCLNYQLTPSSPGASPATARKYNLLKSMVKSYCSNVLHLLRGLTDSTMVYYVLKESEKCTKYFGCFGRITKDYLRNLLELWSGTSSSDVVRIQSFLNIRSLAMAPIVTKNSKSGSYLDECLKGIYLTFVRNSKNTNVHTLPSINLMRNLAVELYGLNQDLSYQHAFTFVRQLAIHLRGAMQTKTKESYKAVYNWQFIHCIDFWANVFSTYCSTAREDHESSPLHAMIYPLTQIAIGTIRLIPTAQYFPLRFHVIRSLISLCNSSNVFIPLAPYIFEVLDSAEIKKKGKTGTLKPLEWDVYIRAPKQHLHTKVYQNGILEQLYDSLIEYYTCYCTSIDFPELVGPGVVQLKRYMKKSTNVNFNKQIHGLIDKIDGTSKLIQEKRSMVDYSPQNMDKIESFSNGLKPQATPLGKFMNNHRQIKAQKQALLESAREMEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDM0</accession>
    <name>A0A8H7UDM0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DUF2421 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_001246</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDM0"/>
    <dbReference type="OrthoDB" id="68611at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023244">
        <property type="entry name" value="Brefeldin_A-sensitivity_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF1">
        <property type="entry name" value="DUF2421 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02047">
        <property type="entry name" value="BREFELDNASP4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="835"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="880"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="906"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="936"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="8">
        <location>
            <begin position="258"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="9">
        <location>
            <begin position="832"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="7">
        <location>
            <begin position="959"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="749"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2175599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1238" mass="140606" checksum="BE9EC8451C455799" modified="2022-01-19" version="1">MTDSKQRPNPDERLREDGAIIQASPRLSTHMGAGPHDIAAIVGSPENIANSYFSSSSKFDGYHVVLDDGTLKKRTVSLSTLYDVPVGLQSTNSNASLSQHPISESTPLLTSQHNDYDSSQQRYEDYETADTDSSDTDTDTEMPFFPPARHREHRPFFHQRNTPLAVKGFFHRMTAKLPKLPQLTVNHKQVLKCSIAYFIGSLFTFIPVLNALVGNNKTSSHIIATTTVFFNPAKTRGGMVEAAGYGWGYVLFALTVSLGSMITSDYYIDRDMETVAHIISLGFWLAGSAFVVAFLKAYWNKPPVATASSLCFIIIFIILVKEGSANEGDFDTQRIQEYTTAVATGTVITLAVCFLVWPISAAKKLGKDISNTLLSFRLLLKLLTKTFLLDDDLPQFTANKSLQSAIESHRSSFTALKKSLSDAKLEFFNNDLRQNSDTYDDIVKSLQRLAQHVGGLRSSCGLQFEKLKNDQLQANAIPSNQSAESLMEAGKSDRATPKRSRTLARTLSFLPQPKPKDTGTWNVRAGYSRRKIQEEMKRQKRSMSTVIYPSNTPDEPRSLTKAYTFAGPPRVLSSTSANAGMSEPAPSQEVSDHQISTLVDFIRNVRQPMKALAYTCKRTIINLQSRFTGENQANLPSFRLMRENLEKAIALFESSQKEAIFRMYRQQSSYNTASDSKDNPEQHCFNPMEQGEDVFLVYFFVFCLVEFARELAYLVGLVEKLFNKPLSLKESISRWISYCKQFLKGGDEPKKTRNLKRRPSSNFVPNDHNTRNTLHTPLPKTKWRRFFISIWSFFSWFKQQHVRYAMKASAAAVILATPAFLPQTGERFRELRMEWALVTLMVVMTPTVGGTNLVAVYRIFSTLLGCYVAYAFYTLFPANIYALPVLTWLFSIPNFWIILNHKHGKFGQFTLLAYNLVMLNKYNYRDDDSVEVSTLALHRFFAVAVGVVFGLFMTAYIWPYEARTELRKGLSDFLLNVSLLYQKLISMYSDTPGQTPYGFSHLDTQISETQLVTIQQQKQAATKTFMDLELNLQRMLIGLQDLLAQTPNEPRLKGPFPISTYSAMLGSCQNILDKLLAMRIVILKDEWFSLVRRDFIYPVNPERKEMVGNILLYIYLLASALRLKTPLPPYMPPARQAWEKLLLCLRQLPAVKTRKLGEPDEAYIFYFAYVVMMEDVIREMDKVWNFESFILPLIMSDRFMFSVQMSVNMKDLFGSLVPDEQWKQYFQTPMLTDSSSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UE16</accession>
    <name>A0A8H7UE16_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sec63-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_007168</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18020">
        <property type="entry name" value="DEXHc_ASCC3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18022">
        <property type="entry name" value="DEXHc_ASCC3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000198">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000002">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000113">
        <property type="entry name" value="activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000231">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF13">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="380"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="586"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="1243"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="1450"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2182241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2060" mass="232837" checksum="7008A761480AB7B9" modified="2022-01-19" version="1">MVQALYTHANLFKQIFENSSPKKKGKGKQQTATGKNTEFEWSQPLQELHAFLESHRSTVADRESTGKDNGHDQYNDIEFNLPTPSLLAEEQELESLISRLEEKPEHVIPNEKVENVQYNRDWLLLKCREYIQNTGSSAFTDTKLCTDLFTILRSKANEDTLQNNLIDLLGFESLDFVSDLLLNRDLLVKNIMSQADRSEAKTTEYVHTEDVRKTAPGPGVTVQSIAEIQEMKRLRKEQKKALRQSNRDERDENEVSADILGFESDNWKAAREEALTGASQRPLFSSSYKIAEQPTYPHVYQSGKSGNTLSAFGTRYALPMGTTRDDYKDHEEITIPVTKQAPIRVGEKRVRIDELDPLCSGAFKAGAYETLNRVQSIVYPIAYGTNENMLVCAPTGAGKTDVAMLTVLRCIAQYCDPSPASVMGVPDISFQIAKSDFKIVYVAPMKALAAEVVEKMGKRLKFLGISVREFTGDMQLTKAEISTTQFIVTTPEKWDVVTRKGTGDVELAQKVKLLIIDEVHLLHEDRGAVLESIVARTLRQVESSQSLIRIVGLSATLPNYLDVAAFLRVNPYQGLFFFDGGFRPVPLEQHLIGIKGKANSLPANERMNRVCFDKVSKMVEDGHQVMVFVHARKETVKTAKMLKEEVMAEGIASLFDPTETPKYDHYKRDVARSKNKELREMFQYGFGMHHAGMLRSDRTLTERMFADGVLKVLCCTATLAWGVNLPAYAVVIKGTQVYDSQKGSFVDLSILDVLQIFGRAGRPQYEDQGVGFILTSHDKLGHYVSSLTQQHPIESKFIENMVDNLNAEICLGTVTNVDEAVTWLSYTFLYVRMKKNPLVYGMDHTEPAEDPLLGAKRRQLIILAARKLAKNQMIIFDEATGYLTAKDLGRIASNFYIRHTSVEIFNTIMKPRMTEADVMAMVSLSTEFDNIKARETEAKELAKLVEQDCACDIKGGTDSTHGKVNILLQSYISNAYLEDFALVSDCAYVAQNAGRIVRALFEIALNRNWGPTASVLLSINKAIEKRMWTFEHPLAQMGLPSNIIDKLQNRTHVPSIEEMRDMEPAELGELVHHKRMGMTIAKCVDQFPMLILDAKIAPITRNVLSVELSIIPDFVWNERVHNNSQAWWIWAEDSENTEIYYSEYFVLSKKQLGETIQIGFTIPVVEPLPSQIYIRAVSDRWLGSETVLPVSFQHLILPQLYPPHTDLLDLQPLPVSALKNEVLENICAKRFTHFNPVQTQIFHTLYHTEHNSLIGAPTGSGKTIAAELAMWAAFRDYPGSKVVYIAPMKALVRERVADWNKRVCGPTKKKLVELTGDVTPDLKTIEEADIIITTPEKWDGISRSWQTRGYVQKVSCVIIDEIHLLGGDRGPILEVIVSRMNYIGSQLDRKVRIVGLSTALANARDLADWLGIDEVGLFNFRHSVRPVPLEVYIDGFPGKNYCPRMATMNKPTYAAIKTHSPKQPVIVFVSSRRQTRLTAQDLIAYCGMEDNPRQWLSVPDEQIELLLDQVHDESLKMALAFGIGLHHAGLTESDRKIVEELYLNLKIQILIATSTLAWGVNFPAHLVVVKGTEYYNYKVGRYVDYPITDVLQMMGRAGRPQFDNSGIARIFVHDVKKNFFKKFLHEPFPVESSLHKFMDDHIAAEIVAGTITSKQDALDYLTWTYFYRRLQQNPTYYGLEDASQGGVNAFLSQTINDVVSRLEESGCVEVTADFELDPTISARIASYYYLRHQTLRHFRQTIQADSPFEDLLSILSNVPEYSELPVRCNEDLLNREIEKDVEYPVQTMESYISPHVKAYVLIQAHFTRLPLPISDYITDQITVLDSAIRFCQAMIDVAADTGLLTTCLTIMNMLQCIKQARYLHDSTLLTLPGIDESMLGKIKHKGKPISSLAEITQFNPAEISKIFSSIQQLSRDQVNEIARVVSRLPVLDVNVKLDSKKSYLIPETEYKIKIEIKRLPRFKGPHDGRIYAPKFPKTQYESWWLVLGDTETDELHALKRISMRNGPNETLVDKVNTHVTIDAPSHLGKHEYTLFVMSDGYLGLDQMVPIPFETRVDLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEB8</accession>
    <name>A0A8H7UEB8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">White collar 2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_007472</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEB8"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658:SF18">
        <property type="entry name" value="PROTEIN GAT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="118"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="7">
        <location>
            <begin position="414"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2182541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="50627" checksum="0C0B7495091207E8" modified="2022-01-19" version="1">MNPYGYTSAPPGYAQYAAQHGNIFISTPETFTAQAPAFAPVPTGHVDTNGGITHQTTIDFSNALRHKNDYDMAQNQLLTSTSDMTAALMSAIDNHNAPRTNGRSLASNTTSSNDFTKRKNWDQRIIEELTDFLHVLSPVGKILFASPSSVELVGYSPDELLGRSITDFLHAEDIDMFIREFNLAIHTRSEFKVYYRFRKKDDKFITFEVIGHPYFGGNGESDIPKCFFGIAQPYPTKAGSMLDSFLELKIENEKLRKQLKELQSQCGDDRFAYSSSNDSSASPGQTERISDSIYTSLIEPQQQSVQSQLAANELLGDGMELNDSNTLDLLSSMDYTSANDVPTGITAHHMGHDHRSEAPQQSKIMSSTALSPKALHKQKDGIAAAAPLAVDDKDIKAKQRKKKKQRLVEDEHVCHECGCVESPEWRRGPNGPKTLCNACGLRYSKYSKKQKPNGDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UES8</accession>
    <name>A0A8H7UES8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UES8"/>
    <dbReference type="OrthoDB" id="2265055at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="39"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="441" mass="49395" checksum="54C2B7E1DE7E6DC3" modified="2022-01-19" version="1">MQFTTAAACTTLNNESIASLGMASELLPLRMAVQIQRTATVLTDLPEDIMLYILNNFIPLIDLWQLLQVSRRFRILSKDVIRRTWKIDLQSSTESLFRVQFRGALITLDAISCKLPPLTPTRRAPSLSSALSSAGQSIYSRLGNGSALSMRTAEPGPLRITLSSRPDGNMSSEDHSSDLQQYADSLEPSPITPHDGGHNFWSSPSAEGSDQGEYTDAIDTHQEHPALAQFKAMAGSLIEEECLHQRIIRGIISHTHRYVLIENIDTRNRLRAAVDTIFHHVVFVSSGTHREDRWSRASAAAFVRLLKRLDTAIPSHGSEMTYTLSDNLKAFLEYSTYRLMAAKRRNHYVWAKRTIDTLSSCANLVGAALLVKMLTEPQVEGAIRKMCELLKDSQIPTETRRTILTTLLNGWLIDREPIYTDLCSLLQHEIDDCAIILKLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEY7</accession>
    <name>A0A8H7UEY7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">5'-3' exoribonuclease</fullName>
            <ecNumber evidence="15">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">INT43_007558</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Possesses 5'-&gt;3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Possesses 5'-&gt;3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote the termination of transcription by RNA polymerase II. Essential for vegetative cell growth and chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with RAI1; the interaction is direct, stabilizes RAT1 protein structure and may stimulate its exoribonuclease activity. The interaction also stimulates RAI1 pyrophosphohydrolase activity, probably by recruiting it to mRNA substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="15"/>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEY7"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000003">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000005">
        <property type="entry name" value="5'-3' exoribonuclease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017151">
        <property type="entry name" value="Xrn2/3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF41">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037239">
        <property type="entry name" value="Exonuclease_Xrn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <keyword evidence="16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="18">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="412"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="916"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="976"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="931"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="976"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG2176904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1035" mass="115548" checksum="80CFB627A67B4BBF" modified="2022-01-19" version="1">MGVPALFRWLSNKFPKIVTQCVEEQPKKVNGVEVPIDPTKPNPNGEEFDNLYLDMNAIIHPCCHPENKPAPETEDEMMIDIFEYIDRIVTMIRPRSLLYMAIDGVAPRAKMNQQRSRRFRAAQLAQVELEAKEKVQQELMAIGQLHQLPVKKKAFDSNCITPGTPFMDNLATCLRYHIAHKQNTDPAWKDLKVILSDASAAGEGEHKMMEYIRQQRARPEHNPNTVHVMYGLDADLIMLALATHEAHFKILREDVFAKEASSKNCFVCGKPGHRAAECRNQVSASNQPAEPAQDDKAAPPKPYVLMHVEVLREYLEYALKPENPDVVWDLEHAIDDWVFLCFFVGNDFLPHLPSLEIREGAIDTLCTIWKKCLPVMGGYMTSKGEVDLAKVQFLVTELGKMEDQIFMDRKMKEERRAQGAKRRKLENDRRKIEREQYDNGPTFGDNTAVPVFAPSEGMSNHDVVANRASLRMANQSAAAALKAEIMGTAQDGQTADESGQHGTKRKADDIEDEFATEVDQVEEIDESDEPDNEAAGRAILARVAAEKKAKDDAAQAREPDDEVRFWEAGWKGRFYKNKFGIAENDFEEKQKIVKAYCEGLCWVFKYYCEGCVSWSWYYPYHYAPMASDFVDLDQMKIEFELNAPLRPFEQLMGVLPAASRDHIPKAFHHLMTDEFSPIIDFYPVDFDVDMDGKKWEWQGVVKLPFIDKNRLLEAMDTVYDQLTEEEQIRNTLGVDKLFVADTNKLYDFISTVYTKRASQEPIPLDPSKSDGITGFVNNDPDCIPRSTLRSPLPDHDLPDIANDRSLSVIYTAPNPGARLPFKPTLLKGARLGKKRLNWEDLQRATFEKQEHRPRGDRYDPQGQHLAEHRQYNNRSGGNRNNGYYQANDGYGGGYGGGGGGGRGGGYSGGYGGGYQQQAPYQSYDRQPNRGGYQGGGGYGGPRGNDGYGRDGGYGGNHGNNYGGNYNSNRGYRGGGGGGGYQGGQSHGGGYRGGGGRGGGRGGYQNNGGYQGGQSHGGGYRGGGRGGGYNSHNQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFD9</accession>
    <name>A0A8H7UFD9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome b-c1 complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Complex III subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_007981</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UQCRQ/QCR8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFD9"/>
    <dbReference type="OrthoDB" id="6683853at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.210:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.210">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004205">
        <property type="entry name" value="Cyt_bc1_su8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036642">
        <property type="entry name" value="Cyt_bc1_su8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119:SF2">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02939">
        <property type="entry name" value="UcrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81508">
        <property type="entry name" value="Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2177324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="119" mass="13139" checksum="149516F483B66936" modified="2022-01-19" version="1">MTSTELYFEKGWWSQISTLQTLNCRFYNIMGGHGYMGWWGNMGGPKQKGITTYAISPFQQKPFAGVARAAIFNTARRVTGQIPYVGVAFGIGYGIYAWASAQHEFLLSKAGHAASGEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFN1</accession>
    <name>A0A8H7UFN1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_003688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFN1"/>
    <dbReference type="OrthoDB" id="2338404at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2179902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="662" mass="74236" checksum="7B06175AE17F1047" modified="2022-01-19" version="1">MFNSSASPATRLVLSDSETSLLLDSLEWRYALTPTGELAPEAAMAVSIRPICHLVKRTDRFVTEITTQSNWTRNLVQNNVLWGNTDFDDLQVLAQCKMLFPHMMKELPLPQSGTSVRKILHLVQCETMGHFSLVNVMRAVKSLEQKLHEAVLSWPENKSSCYEALDKVFGTYGFLMPTKITLEDSTRSKAAFMVAKAQANKSLARINSMDELKGTHVFKPKADIIKRPYDILLYTSQEGPGTQFESWEIIKRTELQPIYEVLPTELGRKIQAVLYERANPIRVGDTIRLQNLANQKYLAWRLNEHNIEPGLCLPTADSSLLRLAQWRLRRSDNVKAVNAQVKYGHAIFIEAVLGPVDSDLCVLLSLKDDKSNDRQELLLLQNKDWNEDSSFLVEYILTSAEPETVDMQISKIKPLNHGDIIFLSQKKMARYLSSKKVDDEIKGPAQLRRRSSSFGSASAVISRIRRMSLTRSTIAMAASQSGMEWDKIQFVECGSDATSDEEKWIVLSDKANHFARSTVGDSSAAADLRGLNSVSTQPSRLSTTPRFITTGTTPIYRTSTGTDCSYQDKSEQLLDMSDQLTTTTDASSFSVSGITTVSLKSFRSASIPSPSMSMLSLDTRNDYNAPIFDLIKKKKSLSHRAKELLNKASLMSLRDIGMRFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHC2</accession>
    <name>A0A8H7UHC2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DIS3-like exonuclease 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Ribosomal RNA-processing protein 44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">INT43_003674</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHC2"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09862">
        <property type="entry name" value="PIN_Rrp44-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000021">
        <property type="entry name" value="DIS3-like exonuclease 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF30">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RNB" evidence="18">
        <location>
            <begin position="471"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="999"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1002"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG2179888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1046" mass="118438" checksum="84584458B8CBD4D8" modified="2022-01-19" version="1">MQRRGHEFYRKSHSNSIVKLVRERYIRDDIPCQSEACMRNPTCHEMSSLLQPAMLSAEATHYVIPDISVSIRYLEILEQEELTNIIIPQTVMLSLQQHDKTRTYKRLRKIASDPRRSSIVFYNEIFAETLVSRLPGESSVQREERALLKLGEWYHQHTGKRIIVLSEQFSAATASGVDVYNVEQYLKEFWPHHTTLQNLREVLKEAELEEDLETIKLFSSTDRNKSRPVAGYTEYKSPEELEAGIKSQRYVAGVLKVNQSNRDQASIMTKMKDMSEIMIIGNDNRNRSVHGDMVIVEPFPDSNRANPSFDISYDGTNDDEEEFEVSVAAKASGGRPVGRVVGVLQRNWRTYVATLQEDAAETGGKIHLAVPLDNIIPKIRIRHHDVNLIRDQRIVVRIDSWPASSQYPNGHFVKSLGPIHQLDTEISAILVEHGIPESQASRGFAEACLREMPVDSPEQPWQPSTEEVSSRRDLRNLDIFSIDPPNCQDIDDALSITEVANGRLELGVHIADVSFFVKENSHTDLEARARGTTVYLADRRFDMLPTVLSERVCSLRHHVDRYAVSVIWTLDKNYKVVDSWFGRSVIRSACEMEYEQAQELLNGADKVQGLDNKLAKRLKKSIVKLVDVLRVVRERRLGKGALELESSEVKFQIASEHNITDIIPKKELEIHEIVAEAMIMANGAVAERILKGFKDSSLLRHHPPPTQARFKALEEAAMSKGFAIDYSTNKTLAQSLEHIANQSSDDPVLVSLLKTMATMAMNEAGYISSGNMAEEDYYHYGLALQYYTHFTSPIRRYADVIVHRQLLNCVETAPEKSLLPSSLLNSNTKVVELCSNLNLKTRESKLAQRDSAELFQSLYVLQQLKKGPLVMNGIISDIRANGFFVYVPRLVLKGPVYLRDKSGASLVPLSLINGQTENENNYISNCTLDSNNQTRIIVQAAELPHPITFQLFDHVQVSLKLHTSHAHRHKVHMTLVGLDHREASNVKLSTKALTEQIISGESQDRASASEDLPKVSKKFKQTKQNDSVYAILENFRQMSLIEEKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHE3</accession>
    <name>A0A8H7UHE3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_006150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHE3"/>
    <dbReference type="OrthoDB" id="1939603at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF3">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="200"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2183155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="328" mass="35453" checksum="1EF8AFA59D94F873" modified="2022-01-19" version="1">MASFTSHAASSSPTIAGNQQDAATSYLQSLEAVPSLPPLSHLLTTEQHDLAAAAAAAAAVAADSQSPVTSSVNTTPHPSSLGFSTPTTSAATVSSSNGLYYTQAPVIPPTVPSAMMMAPAGSHPADMFPLDPQFLPLDATTTSMANINPYPSIAPRRERNSSVSSSVSSDTNKVYSFVAIPGTNQKKRPRRRYDEIERLYHCNWQGCTKAYGTLNHLNAHVSMQKHGPKRSPSEFKEMRKEWRRQKKEREAARKAADEHMKKEIINHQQHQQQQFAAAAAAAAMPLHAMPPQLGSYSMTHQIPTHASQYQPIGITPNYAMSSGIPGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHZ3</accession>
    <name>A0A8H7UHZ3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="11">HMG-CoA reductase</shortName>
            <ecNumber evidence="11">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_006781</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="11"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHZ3"/>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004816">
        <property type="entry name" value="HMG_CoA_Rdtase_metazoan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00920">
        <property type="entry name" value="2A060605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="12">
        <location>
            <begin position="286"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2183770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1180" mass="128163" checksum="7781904B0F686E6E" modified="2022-01-19" version="1">MSILTPSGSAFRSVSTLLGKGIHRAARISARNPIEMIVAMLILASFSYFALLNLAKTSDIFSGTTTSLQPAFAYRAGDAVNFTQRDEKDIKSLSPSDAVKVQLKQIVIEDPNTSKRSGGVLKRKVLEAVYQFQDIVEHQILVPDGPPATKQYSFDSDLCYKQNNQCFRHSPLDVWNNDLLAIQADKDLTGTVKRDFEANAHQFKLGEDEKKIEALVLSYAFNATGNIRPQLAEQWAEKVATLPPGALISQSSADDQQQNTFVWLYIIARNVVYRIRELISDADNIDIIVILGGYIMMITTFVSLYTNMRAMGSKYTLATAVIASGFFSFMLALLTVHYLGVDVYPVVLAEAIPFLVVTIGFERPYKLTKRVLQTSEQTSISKQNVHETVIRAVDAVALSVARECSMEIFVLALGAKSGIDGLREFCLLSAILLAYDFIIMFTWYTAVLALKLELRRIKEINSTNDVAGGVKTGTAQTGNTNPVHIRRTVLKAFQSEKQASHSKTGENVDGPIIGRVKLLMIVGFLVMHFLELCTFPSSTASPRVDISDPAVSTVLNALFAQHKQSAKSLLPLVVEVSSPLKFHVVDHSYYVLPEFLEKPLNYMFSSYSDYIQDPVISKWLCLALVVSLFLNTYLFNVAKQPKQLVEHQAKEKKTIVSENIAPFIELSDKQKISVTNVVPTKVEGPSVPSSPVVRHEAHRHHRRASILHSKVIRPIEECQVILKNPEEGPNSVSDEEVVQLCQAGKIAPYALEKVLQDFERAVKVRRSLISRASMTKTLEASALPVEHYDYSKVMGACCENVIGYMPIPVGVAGPMIIDGESIHIPMATTEGCLVASAARGCKAINAGGGATTVLTADGMTRGPCVEFPNITQAAECKRWVEEYGRQEVMDAFNSTSRFARLRKLKVTLAGKLVFIRFSTTTGDAMGMNMISKGSEKALACIAERFPDMQIISLSGNYCTDKKPAAINWIDGRGKSVVAEAIIPGEVVEKTLKTTVAALVELNISKNLVGSAMAGSVGGFNAHAANILTAVYIATGQDPAQNVESSNCITLMKAVNNGTDLHISCTMPSVEVGTIGGGTILPPQQSMLDMLGVRGPHPEEPGKNAQRLARIICASVMAGELSLCAALAAGHLVRAHMAHNRAAPGAAATTAPVVTPAPTPVSGANITAAPSSQNFECLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIJ6</accession>
    <name>A0A8H7UIJ6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_008685</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIJ6"/>
    <dbReference type="OrthoDB" id="2365484at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.770:FF:000001">
        <property type="entry name" value="60S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018262">
        <property type="entry name" value="Ribosomal_eL27_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01107">
        <property type="entry name" value="RIBOSOMAL_L27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2181103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="136" mass="15795" checksum="84235E89809D51EE" modified="2022-01-19" version="1">MVKFLKAGKVVVILQGRYAGKKAVIVRNHDEGTKDRPYGYAVVAGVERYPLKVTRSMGKKKVAKRSKVKPFIKVVNYNHMMPTRYTLELEQIKGTISSETFKEPSQREDAKKTIKKLFEERHNSGKNKWFFSKLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UK61</accession>
    <name>A0A8H7UK61_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UK61"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF102">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2184747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="15868" checksum="9326819C81DD7A22" modified="2022-01-19" version="1">MSVPNAQGDSLPLSINSATDIESPIPRFVEVVRYFASGWHIQPKGAKKPYNPVLGEIFRSRYAFNDGSKGIYLAEQVSHHPPISAYFFANPQKGITIQGDLRPKGKFLGNSAATLLHGSTDIVMLSRDETYRITFPNVYAKGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKB5</accession>
    <name>A0A8H7UKB5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sacsin/Nov domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10031156at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022155">
        <property type="entry name" value="DUF3684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12449">
        <property type="entry name" value="DUF3684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacsin/Nov" evidence="2">
        <location>
            <begin position="64"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1405"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1430"/>
            <end position="1450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2182049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1677" mass="191642" checksum="07733858DDE0C313" modified="2022-01-19" version="1">MVLSSKSSHWVKAVKGSKEAHSSPVTLSRTNMVQMEQSKKLDQLRDHIMSAQGPEEKVEVNQRHLIDKILARYSAEHVVYRELMQNADDASAQAVEIIFSTDSAESEEPNLKEKSTRLIIKNNGIPFRPEDWARLKSIAEGNPVNQRMIDEQKIGAFGVGFYSLFSICESPFVASGENCMGFYFKGDQLYTRRGKLEGDDASAWTSILMDMREPIDIPEMTEFGQFLSCSLGFTANLREITVYVDKHKVFHILKKTDESRPMLIDSNKFFATSVPDISRDLEREMERSTKKKPPKQTKFQLVFTGREELDASENTNVVFKDLVPYPEQGRIFIGFPTHQTTGCCSHMAARFIPTVERESIDFADPYIGKWNRELLAMGGLLCRIIYDDEMHQIQKIYAELVETDDLVDIEELSLEDGSDGQHLTPRTWLRRRAYHALQAFTFKTSTPSHIVGNNQEHFFYEMAKTDMEVMTSQGIRSLTITRSISPSVPGTQVSDLVTKFIKTIPLVLIPQEGELGATFKKLVSTKRLKTLGIKDVLKELESRPLNNEEMIACMKWWIKLQENRQAGWDAETRMLLNSPQTRGEFLTKALLQHSDDKLIQLASIKHYVNQKFIPIDMPLPESVLPFEISCKFQQVALTSHFGWTQLQLLEWVQYVATKPDLETSPVFAQKVLSVISRNLNVPQMVSTQQPSEIACLLKEKRCIPTKQGMRFPHEAYFPTVKLFDDLPVVLLDNPRAVSEPTLLLLGVRKHVDLQMIFDRLVSQGSWSHFELVKYLASVEDTISSKEIARVKETAIFPKASPSNSVEIEKEGSKVTPKRYKAYELYAPLEELEPLKLPTIQWEGKWRASSPQAQFLEKLGLRCYPSLTDILQLASDQKISQEQRNQSLKFLVDHFDKYYEKDYHVDRVLQPIVPCQGGEYANPRDCYVNPECAILGFKVIVDDMKMFRDKLGIAEDPNAPQLLTAFKKHITKNQALARRIFEYMASRISLGQSVWNQLQTLEFIPVRDSRAMSKEAKDTTMMRPTECYFVSKDKEQDFHQELFVFIDFGDVANTFLRCCGVKNEPTIVELSQMMVRDPQLYWKLSGGGENYLNVLRRIANQFYQIKSNVSLISQMKRAKILVGYRQKDAEDDKVGENITSVVACRVSAQEVYINDDATGFHMFSPICAPTEPVLEELYRELGCIKLSSQIKEHTSCSGKPVISEKALSIQSRILERIPIILYQVFVDAPQRKSELRLSQEKALRKLMVVEVSEIMVTRVFVPTGQQDVQKTTACADIRNVTMNISNAKEVDYYDVASSLCHLLFKRIGFNDAIIFERYLVATLSNLRSRGVPVDRVLHNLKVSQQPEAASQDTEQQTIKSAEVASDANGMVAQVQAVFPDCDPKYIHSELQKEKENHVENVVNRLLTTPYPKKHNRRRSSSIGIKGSNNDNDGHVEKIPEQKPQSDKSRGDKNVFTHLFNKYTQQSHQLLDNIKSPNTPKAVKPSRQTPVINDVQSRQENIKRDLLQAVRQCQPNSAKNVFSPPTAQTVAEYCDATPSQNLKFIEKANGYEFYVHNDVDGSFVLKQFGEQLKHFSEIIRTLSGVFGVNEVAIHMFYDPNGNAIAFYRNGSLFFNLRFYLSLHDHTSGRLTDREKQTKIRDAMKFWYLTMCHELAHYFQDTHNAQHEVGGVRDRIFKMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7ULH2</accession>
    <name>A0A8H7ULH2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_006184</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ATG13 family. Fungi subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7ULH2"/>
    <dbReference type="OrthoDB" id="70161at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040182">
        <property type="entry name" value="ATG13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018731">
        <property type="entry name" value="Atg13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10033">
        <property type="entry name" value="ATG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 13 N-terminal" evidence="5">
        <location>
            <begin position="88"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="335"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="512"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="588"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="617"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="335"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="557"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2183189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="675" mass="75517" checksum="479E4B77AEAB11E5" modified="2022-01-19" version="1">MYSKDRQPAVSTNPSTSNHTTHYKQNSRYESSHNHSSQELAATQAASKPSYDFSPRQDYSNKNDSHIPDKHVASSNVTRNDRRQDHIVQNFYAKVAQIVIQSRAYLENTKTFYSHRYSYSLEEKESIPKRLNRWFNLLTSDVDGLRDDLKFWRHQIAKGADRITPYPMIIDIYLDISKVPDDMVLITNNRDLQKPVNTLGTNGCKIQSILLETWTLQLNECEMDEYSGADGASLLFTDAPLSRGASNECETYEFADILSPIGALSLSVQYRTDCTIQAKYATVKDALGLESAIDDWQLSRLSRRSSNRTEDIEWPLNPYGPSAGVHRYSISPASSISSSFSTEESSTTTSVSYRRPSTPLVSPFKSKSLSSSFGTGSTQTKSIDSYPTSESNPPRNFSSSFERYYSNKAGREDDDYHSTSVDCSEPVSAESFAHQKQDPQAASGGTFSCDDELSVFMGIVEDKPDLKMFRRPSLRTMSSYEDGERDLFLESGSIGKSKAALSRFQYMKTSHTSLSESLSSSNTSSRPMSTAHSATDNLSSSISSISSFRSRELSNSGASHHQPTEIKSSTSSRQTADAKRASFLALQPKAIEEVPSPHSESYRTRRVQVSPPLVDRFNFKPSRQSSRPVSQTLPSTANRGYHRSTVNGYELFSQNTPPQEEDDPLIFAMNDMEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UM33</accession>
    <name>A0A8H7UM33_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_006815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UM33"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF152">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034198815" description="NAD(P)-binding protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2183804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="51298" checksum="35E6947CC892013F" modified="2022-01-19" version="1">MDLILTLLPPIAAVFLFIYMQQQKKAAQQFDQSLFPDLKYTDRPSQTQSPRQSFIDIVHLFCVKATWIPAFFRVYFLGIFEFVINAIEKFILPNPNGSKESQIQDLIDSARGRGDLKGKLAVITGGDSGIGCELAKALIECDMDVIITGRSERTLQQAAGRIRSAKNVGHDRLKYIILELSSFGKVVAFTKELKESLHGRSIDIFVSEYAFYKQEDEFNTDINIMIDNAGVMNCPFEMTDNKLEYQSQVNCFATILTTLYILPLMSTKSRIITTSSSTLYAANHIDISKFFSGYRLDGLGAYAQSKLSLALLTNYLSERIQSVNSDITINSCHPGIVNTSLFQYSTVFTLSIFRPIFRLIMLSPREGILSSLHLCLDPSLDSVSGEFWLNQLPRPLGSITMGSQQEAEESQTVTIQRWLWQTSLDIWSMSEDDASQLFNLCREQRRDTEVAKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UM51</accession>
    <name>A0A8H7UM51_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_000751</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UM51"/>
    <dbReference type="OrthoDB" id="5358475at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049046">
        <property type="entry name" value="Beta-AFase-like_GH127_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31151">
        <property type="entry name" value="PROLINE-TRNA LIGASE (DUF1680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31151:SF0">
        <property type="entry name" value="PROLINE-TRNA LIGASE (DUF1680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20736">
        <property type="entry name" value="Glyco_hydro127M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034491927" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 catalytic" evidence="2">
        <location>
            <begin position="445"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 middle" evidence="3">
        <location>
            <begin position="585"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2184838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="798" mass="87820" checksum="51639E3EDEB6B3F1" modified="2022-01-19" version="1">MVKLLLSTTLLLSTLSSAFASIDPNQTYRMVIAGGRRGCYNYLSFRDNWRMLDTWYEDDFSGNQHFKLQPVNGTTDTYNIIGVNRAGCDNMLSCNNCPDNEVNFWNVDDGSGRQRWKLAPVSGKNNTYTVSLVGGRSGCNTYLGLQGCAVSDNATLAASDDGSGAQQWQFLPVGASASTPLEPFQFAPLNVGEIKPAGWLRDQLQIQANGLAGHLYDFYSYINANPWVGGSSDYADLHESGPYWLNGMVPLAFQLEDDRLLGQVNDYVNYIISHQESDGWLGPDDPYILWPRFPAMLALMQYAQANSSATTTVVNTMHKFLDRANDMLNNNTGFEDWGRARWYDFAISVMWLLDEYPNGKEATLLNILKQVRTQGDDWNVWFTDAQFPQGDAGTYTVISHGVNNGQAMKSEAVAYRFSHDSADLASTKKRVQLMEEYHNRPSGIFGCDEHLAGNGPSRGSELCTVVETSYSYIYMYMVAGDNEYADYVERLIFNALPATLTEDMWAHQYLQQYNQISAKNMTPHFWNTDGSYSNVFGLEPNYPCCTVNHPQGWPKYVSHMFFTVNNKAGLVAGLLGPASVNTTLASNNQVSVTADTLYPFNSVLNYTIQAQKSFSFGVRIPAWATTVKYSVNGGPQQSGKLNSQNLITVKAAAGKTTITVTIPMVPRTTKGYNNATAVYNGPLAYALPLNYTTKVLATNPEQSKDYEFDASGTWQMAIDPSSLKYNGDASSVSSVPFSTSNATVSMSATVCPINWPTANSSVAEPPSSPATCTGSKKAVQLLPFGSTRLRMGEMPALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UMC6</accession>
    <name>A0A8H7UMC6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_000991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UMC6"/>
    <dbReference type="OrthoDB" id="2413591at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2185078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="399" mass="47152" checksum="D0D71CC56D178995" modified="2022-01-19" version="1">MFDCYCRRRPVRAYLPVPPKVQVLVPKTLDITAIQKCPVDYNCEFISKEDKAASEKLKNIYVIYQENYFIANLDGYEVKCDYNCRNRVMTTLCHYRSFDQQKISSLLDKKFDLDFIDDVVHNNNPPLMIFSNEELFPTNYQRNSIMENYSSVDVQQLASNTQSKPCRQDFFLIYLGEKEVQIFCRSCNKSRKKKDARYMCCSMKTLETYEYSWELIRRVDQMLLGDVDECIAKLKAEDEVAKLQKPAKRMTNFRLTDIDGNLVEENVDYYLQLFTVPEDVLKIRSYSNSFYATYRLNRSEKIIVRYVVQDNIHYLTYKDQILQGVGNQDEFGFDEQVPEKKARLEFHVTENNAFKTVRWDDDIWLTFEKHTLCYSSITFNSSIESVRVPKPLELCLKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UNG0</accession>
    <name>A0A8H7UNG0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED6</name>
        <name evidence="10" type="ORF">INT43_002641</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UNG0"/>
    <dbReference type="OrthoDB" id="344220at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="225"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2186203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="263" mass="29471" checksum="8B2F22053262220B" modified="2022-01-19" version="1">MEVEDLTSVEWRDTGWLEHFGGFQNRQMVLDYFAMSPFWDRQSNNQVLAMQTQFNDLGQAESTETALRKMTGIEFAVVHEQPPVYVIQKQYRRGPSANDVTPIATYYITGANIYQSPTVYSVIANRLLTSLFHVNSAFQDAQSMMEYFPAKGYGWKSPSTTSNLQKQSRAGKSASSQAYLKAQETQEYRVLMEKAIDTSAMRISQKEAASQTADGGLAAGAKVLDKQGSQLSSQTTQSDLVGTKRQRRKQEDTAAKKKKKTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCG4</accession>
    <name>A0A8H7PCG4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_002924</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCG4"/>
    <dbReference type="OrthoDB" id="10250990at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052174">
        <property type="entry name" value="Flavoredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43567:SF1">
        <property type="entry name" value="FLAVOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43567">
        <property type="entry name" value="FLAVOREDOXIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="4">
        <location>
            <begin position="18"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2171302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="251" mass="27939" checksum="9E60CB006775F5B5" modified="2022-01-19" version="1">MPSKPDFHQTIDPAILYFGTPVVIISTENEDGTYNLAPMSSAWWLHDRCILGLGKNAQTWSNLIRTGQCVLNLPTEDMVSYVNLLAKTTGVEDIAPRKAVMGYTFVKDKFKKSGLHPVESCMIRPPRILECPIQMEAVLVTSHDLKGDLAEEQRTASAIEVKIIQVHAKQSVQLAGQINKIDPDKWKPLIMSFQHFYGLSSRSEDSKLATIDEEMYRTVKRQSSLRSPDVSSKSAESNLLAIAALGSMTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCL9</accession>
    <name>A0A8H7PCL9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial inner membrane protease subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_009068</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCL9"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000005">
        <property type="entry name" value="Mitochondrial inner membrane protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase S26" evidence="14">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA-binding protein Alba-like" evidence="13">
        <location>
            <begin position="224"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2171407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="348" mass="38646" checksum="428D2CE5E27B1280" modified="2022-01-19" version="1">MTSRLWSHPNTRAAIKTLTWFPVIFFFLENGFSTATVQGRSMQPTFNPDSNKLTPDVVLLSHWGAIGHKFKRGEVVAMTSPHNPNLTITKRIIALEGDTVRPLPQSEQKSAVHVPKGHCWVEGDESFHSRDSNFFGAVPLGLISSKVTYILWPLSRFGKVELKPNRDRVSVDSVDAVHLNQQKSKFSRVIASSYTNIRMENYRRQPITASETDAGHTLIKHAENELLISASGKINRYVTVGLELLEKNKTVVIVGSGKAVSKTVSVTEIIKRRMEGALHQYTQIGSSTSTEKWNPVENKEFDQLVVSKHIPVLTIYLCHEPSPDLEKVSGYQPPTKEGTSSGTAGTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDR7</accession>
    <name>A0A8H7PDR7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_008194</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDR7"/>
    <dbReference type="OrthoDB" id="361693at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="4">
        <location>
            <begin position="26"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2171814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="111" mass="12829" checksum="6CCA9BE249DCA4F8" modified="2022-01-19" version="1">MSGARDQLLGVLYQAASQEPEKLKNAQQQLKQWETSPDFYSTLQDIFYDISLPVNVRFVSGLYLKNGIDAYWRKTAKNSIRPEERSQIRSRLLTSLNEENKQVNVDFDNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEZ8</accession>
    <name>A0A8H7PEZ8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEZ8"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="87"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2172698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="430" mass="47412" checksum="E5A7B93CAB990A6F" modified="2022-01-19" version="1">MDNIRQAVRGMPSQLSIPILRQILRLPAPVARIIMNELTEPLGKNQSYIKKVYEGGWTGAWIGEGMAKLESFDQIKERVRSADVVLFNVHGGPFRVGTSTMFMNAYSAWIKILKEKHNINAVIMSVKYRLAPEHKYPAATEDSVKAYKYLARSLGISPHKIVVTGDSAGGAILVETMLEVYAPELLPSSGYGATSDSTTSGKDLPAAMLLVSPVMSAETNSPSWKKNAKFDMIGPKLFKKVFKEYFGTTDPSATDVRLIAMTQMQEGFDRFIPKNVMIVVGSKEVMRDDITEMALRVVKNSNINGQLLSEDYAHDWYVIRDTVKDKNALKRSDRVFADFVANALQQAKIEKEATATGKLIDTGSSINEHETPKSNVQFTRNGVTMKFTKATVLELMSNFEGDNVATDGYGITLDSIADMAGSSQTRLLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PH37</accession>
    <name>A0A8H7PH37_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PH37"/>
    <dbReference type="OrthoDB" id="2371357at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="139" mass="15727" checksum="826BA56F0441F747" modified="2022-01-19" version="1">MTTLSFRKRPQAKAETTMSYETMTHDLSNIPTNGQFTQLHDELSQFLSQENLDIPNITTANITQSKDPKAVVEHMKAENQATREQRQDTRAAANALLQTIHDLEAEQEPVRAAAGQIRQIEQHVQQSSDLLRSTEKDMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHK6</accession>
    <name>A0A8H7PHK6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pentatricopeptide repeat-containing protein-mitochondrial domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_005250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHK6"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057027">
        <property type="entry name" value="TPR_mt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF23">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23276">
        <property type="entry name" value="TPR_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Pentatricopeptide repeat-containing protein-mitochondrial" evidence="7">
        <location>
            <begin position="209"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="314"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2173830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="484" mass="55246" checksum="C0371F3E7B0FBCDA" modified="2022-01-19" version="1">MIQYSKRRNPNGLNNMSSIFQEMEEKSIKFNLDTWVYKLQMLAMKKDTRKLLATFDQILRRYTPSVEIFNVVIKALANEGSITEQVKILGVMREKGVKPDAISYYNMLRNLHDFSRLEQALDIHETALSDGIRPNALSYDHIIRLCGEVDELDLGWKLLQDADKANLPLNITPSIGLPLLRSAAKLEKVDIVQGIWELIQRKSLSLPDDGTAIMVMNLAGKLGNIELASSMIDCLGKQGYQYQEHHFAPLVQAFVGQGDLKGAFSVLEIMRSCAISATKHTASAIFDSIEGNLEKIDQAFYILEQLKQEGKEIDTIAFNVVLRACVRAKDLHRSISTYQEAAKLDVQPNIDTYNYALDACLMARNRQMGDLILTHMKDANVRPNIATFTKRIMLACTQKDYEDAFLYLEEMKQYNIIPPRVCYEHLVKKLVRESDPRVKVALDEMETFGLEITPYLREYIANKGRRQQDRQQDRRQDGNKKPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJ75</accession>
    <name>A0A8H7PJ75_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJ75"/>
    <dbReference type="OrthoDB" id="6157973at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034552789" evidence="1">
        <location>
            <begin position="27"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2174765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="134" mass="14128" checksum="8F844815FE11A563" modified="2022-01-19" version="1">MRQFKQINPLVYCGLLLALLAVTVKADPEMVERGACVVLCDPENPCDAGYTCKSNGCGSQCYANTKRGACIIECGADMPCAAGYTCKSNGCGTQCYADTKAKRGSCIVACGLDEPCRSGYTCRSNGCGTQCFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJB4</accession>
    <name>A0A8H7PJB4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_006018</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJB4"/>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000001">
        <property type="entry name" value="60S ribosomal protein L22 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF31">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL22A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2174956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14326" checksum="D27180ED8A28E1B9" modified="2022-01-19" version="1">MPAQKTASKKSQTHKFVIDCSGPANDKIFDAAAFEKYLHDRIKVEGRTNNLGDVVKITRGGDSKITVAATIPFSKRYLKYLTKRFLKKHQLRDWLRVIATDKQTFELKYFNINQGEDEEDEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJN9</accession>
    <name>A0A8H7PJN9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_006022</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJN9"/>
    <dbReference type="OrthoDB" id="2383663at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2174960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="124" mass="13896" checksum="7678A5C6B3F6FCD5" modified="2022-01-19" version="1" fragment="single">CKKILPIDANTVKTTFNSKAAIRVYNPAFSLNVVKASPKLPNDQCRASVITGKKALGKSAVIRNRARRRIISCARLCFPQHATPGHDYLFFAQPEAVTMPWSTLMGHMQKTLEQVARRFQAKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PK85</accession>
    <name>A0A8H7PK85_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trafficking protein particle complex subunit 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PK85"/>
    <dbReference type="OrthoDB" id="428342at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581">
        <property type="entry name" value="D-ALANYL-D-ALANINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="369"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2175393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="56809" checksum="A6BEDDEB40B44B96" modified="2022-01-19" version="1">MENELKADHILSPTTERPGHHTPGSIAHPPSGINTMPDPVDTFDTIPPTPQAQQPPGLPYQIFNSLTSTIGNMTTTAPRNSQGNQDNIATSPSGNYFPDTYESSSSGEYAGNQPAANQSNTTRKRGYSGTRAHRSLSSASAGTGGVSLGLSLTNSTLFYDIPMSDALSELLEKHLPPERRPRREFVELADLEKMKTKEALQDLMNKKSWRSVARLARNRIVQTNPAHLSEILQLWNVRLNALVKLRLYQLASAELDKLGDLTRQEFTFEYHQGLFPGQSGSMIPFELRILWANLPGWMKHPNTSIERLTLLAMECKKHQAEADKDVWKKREVSLYIMLVNFLLEIKDYPLCISIMTQISEKMMDMPKDSKIVSALGRLHLQLGNIQEAKSIFKNLENLNDHNAEYNRSIKMNSALCNIASGEWKVAKDQLQSILELHTNDFEALNNFAVCLLYLGELDKAIAAMEDLITKASGESDFFMEQAIFNLCTLYELRSDDAMEKKVMLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKC0</accession>
    <name>A0A8H7PKC0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small G-protein Ras2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKC0"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2175622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="20139" checksum="2815A266C24075A2" modified="2022-01-19" version="1">MLTAAPDCSDHYFGLTYDPTIEDSYRKQVVIDEQPCVLEVLDTAGQEEYTALRDQWIRDGEGFLLVYSISSRSTFERVERFRDQIFRVKDVDNVPLMLVGNKCDKVTEREVSREEGYAMAKRLSCDFIETSAKTCVNVERSFYSVVRMIRANREGGYGHPGGKKKNKEKKKCLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKF3</accession>
    <name>A0A8H7PKF3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Xanthine/uracil permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_001145</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKF3"/>
    <dbReference type="OrthoDB" id="431212at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015853">
        <property type="term" value="P:adenine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015854">
        <property type="term" value="P:guanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF1">
        <property type="entry name" value="XANTHINE_URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="559"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2175498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="61649" checksum="7896B414A023AC4F" modified="2022-01-19" version="1">MTWTETVNNRVANSFFGRHFQLEGSGSKKERPGSRFLTELRGGLATFVAMAYIISVNSTIIADSGGPCVCSPAAGATGTAAMCVGDPDYEACKLVVRQDLITATCAIACLASALMGTFANLPMGMAPGMGLNAYFAYTVVGFNGSGKVPYNVAIAAVFIEGLIFLFLSVFGIRQYLARLIPVSIKIATGAGIGLYLCFIGMQSSAGIGLISADPSTLVTLGGCDAAYKDENGVCTAHHMESGRTWLGIMGVYLMTMLSLFKVKGSILICILLVAIISWPRTTNVTFFPYDAAGDAAFDFFKQVVTFHPIEKTLASLEFDLTTSEIWIALITILYVDIMDTTGTLYSMAKFGGYMDERGDFEGSSVAFICDSLCVTIGALFGTSPCTTFVESGAGITEGARTGIAGLVVSICFFISLFFAPIFASFPPWSTGPALILVGSMMIQNVINVNWGYIGDAVPAFLTMAIMPLTYSIADGMIGGLCTYIAINLSVWFVEKASFGRFVVDKSQKEPWAGHHLSGSGILPPWIKRVAAKLSGRVPGDDLPKPGVYELGKASRFAEETHVSLSEDEAVATSEDGHKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKP9</accession>
    <name>A0A8H7PKP9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SF4 helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKP9"/>
    <dbReference type="OrthoDB" id="275278at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01029">
        <property type="entry name" value="TOPRIM_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01122">
        <property type="entry name" value="Twinkle_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034154">
        <property type="entry name" value="TOPRIM_DnaG/twinkle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027032">
        <property type="entry name" value="Twinkle-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12873">
        <property type="entry name" value="T7-LIKE MITOCHONDRIAL DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12873:SF0">
        <property type="entry name" value="TWINKLE MTDNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13481">
        <property type="entry name" value="AAA_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56731">
        <property type="entry name" value="DNA primase core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="1">
        <location>
            <begin position="371"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="615" mass="69042" checksum="B3FC411184F7C158" modified="2022-01-19" version="1" fragment="single">TKRAVQTESVSKPGPEFMSKYYQPRKSEIMDFLYSHQQRPIPTSKPDVVIANCPHCMKVKRNSFAAHIDLQHGNYSCRTCQSKGTWQDYTRALRKKKGDTFKTFSVSDIRGDRKSAQFSRAISEIENYSKELENSATILNNLSKDTGIHKDTLLSYRVGLASYASPDSKLAVVNGEAPGDTQCVTYPQTTYSYHDDREFVVETTRLKACRLDDVQLPVAYDPTAPVATGLFGYHVAPSDAESVVITRNELDAMAVFQATGLPGVSLPTSVYQLPQTVLPLLERFSKIYLWLDDDVDGQLAAETFAHKLGESRCSIVNTRMGDAQGPLNAHQALLQQKDLSHILSTSSALKHDQIIDFHELRDEVYREFLSPEQARGVQSLDLPALNAVLKGHRPGELTILTGPTGVGKTTIISQLSLDFCKSGVTTLWGSFEILNKRLAKKMLCQFAEKDLSQHPQEFDIWADKFEQLPLYFLKFFGSTSIKDVLQACQHAVYAYDVRHIILDNLQFMLSQQGRSSLDRWELQDEAVAELRRFATSKDVHITLVVHPRKENAPALDINSVFGSAKVTQEADNVIIIQKNSQGEDLRFLDIKKNRFDGTLGSIPYKYDNTTLKVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLD1</accession>
    <name>A0A8H7PLD1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Plectin/eS10 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_005513</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLD1"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000025">
        <property type="entry name" value="40S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="93"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2176279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="146" mass="16923" checksum="9925741A5840A3A8" modified="2022-01-19" version="1">MLITKENRKAIYEALFKDGVLVAPKDYNLPKHQDIDVPNLQVIKAMQSLTSRGYVKTQFSWQYYYYSLTNEGIDYLREFLHLPTEIVPATLKRAARPAAPRRPAGEGREGGFRRDRDDYRRKEGASGEFKPEFRGGLGRGRREQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLD8</accession>
    <name>A0A8H7PLD8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_005421</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLD8"/>
    <dbReference type="OrthoDB" id="1045173at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000011">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="26"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2176187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="456" mass="49081" checksum="14E6295AD2DE5A70" modified="2022-01-19" version="1">MADETQSISIDPKTLNPLSPEVISKQATINIGTIGHVAHGKSTVVKAISGVLTVRFKNELERNITIKLGYANAKIYKCDNDACPRPGCYKSYGSSKEDHPPCERPGCGGKMNLVRHVSFVDCPGHDILMTTMLSGAAVMDAAMLLIAGNESCPQPQTSEHLAAIEIMKLKHIIILQNKVDLVKESAAEEQYKDILAFVKGTVADGAPVIPISAQLKYNIDAVSEYITKKVPIPPRDFSAEPRLIVIRSFDVNKPGADTTQLLGGVAGGSILKGVLKVGDEIEVRPGVIVKDQEGKIRCRPILSKILTLHAEKNLLQFAVPGGLIGVGTQMDPTLCRGDRLVGQQLGTPGTLPQIYTELQVSYFLLRRLLGVKTDDKKQAKVAKLTKGELLLVNIGSVSTGGRVVAVKADLARIVLTGPTCTEIGDKVALSRKIDKHWRLIGWGKIKSGAVLEPESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLG3</accession>
    <name>A0A8H7PLG3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_005441</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLG3"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021966">
        <property type="entry name" value="SF3a60_bindingd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12108">
        <property type="entry name" value="SF3a60_bindingd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="9">
        <location>
            <begin position="398"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="337"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2176207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="493" mass="58467" checksum="48371881D738BE6E" modified="2022-01-19" version="1">MNSVLEQQRSVHEEIERLEQAIVDQYMSQPKTQKERLENEHIVSKYLDRITEKSKQLYDLYDDKDGARKKEIDALATTSDSFGEFYERLRVIKDHHRKYPNEMAEPAELEFIYEQKQRHEDGTEEEALETLFSGEEGFGRFLDLNPLYTQYVNLKHIKRVDYLSYLSTFDDFKDTYPKETKVTADYRNYLTALRSYLESFFTRAKPLYNVENLRKETEDQFEQDWKARTVPGWEKKLGEEEEAQPQLFCVACQKQFSKQTVFDSHLTGKKHIKAQKQLMEQKGPMVDQAEIEKARQKALEEKEDKDKPIAWLEVLISKYVEVLSDHRNDTRANVERKQALTDRERALEQEQDELEIMENDSDDEDEDKIYNPLKLPLGWDGKPIPYWLYKLHGLGVEYPCEICGDFVYMGRKAFDKHFQEWRHAHGMRALGIPNTRHFHEITQIDDAYALWDKLKKKGRADDFKADTLEEFEDAEGNVFNKKTYEDLKRQGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLZ0</accession>
    <name>A0A8H7PLZ0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">MGS-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_005542</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Also catalyzes the cyclization of FAICAR to IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PurH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLZ0"/>
    <dbReference type="OrthoDB" id="6017153at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.440:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005492">
        <property type="entry name" value="PRK07106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2176308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="587" mass="64400" checksum="A7FA7F4A473458F2" modified="2022-01-19" version="1">MSQKIAILSVYDKTGLVEFAKNLHSMNVRLLGSGGTAKLVREAGIPIGDVSEITKAPEMLGGRVKTLHPAVHGGILARNIESDEKDLAEQHIEKIDIVVCNLYPFKETVAKEGVTVPQAVEEIDIGGVTLLRAAAKNHARVTIISDPKDYATVISELGNGDVSQDTRNVLALKAFNHTSDYDDAISNYFRQQYSKDVAMMPLRYGANPHQKPAQVFVKEGELPIKVLSGSPGYINLLDALNSWPLVKELKQATDLPAAASFKHVSPAGAAVATPLTDVEKQVFQVEDLKELSPLATAYARARGADRMSSFGDWIALSDKVDVPTAKIISREVSDGVIAPAYDDAALEILRKKKGGKYCVLQMDPNYEPAEIETRQVYGLSLQQKRNNVKIDESLFKNLVTKEANIPKEALTDLIVATIALKYTQSNSVCYAKNGMVAGLGAGQQSRIHCTRLAGEKADNLWMRHHPKVLAFDFKKSVKRADKSNAIDLYVIEQIGEGAEREAWESMFNTVPEPLTAEERKEWMAKQDGVVISSDAFFPFSDNIHRARRSGVKYVAAPSGSVMDQVVIDAADSHNMVMAHTNLRLFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLZ8</accession>
    <name>A0A8H7PLZ8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Plasma membrane ATPase</fullName>
            <ecNumber evidence="13">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_001313</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="13"/>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLZ8"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000004">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000211">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="679"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="747"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="819"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="852"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="45"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="887"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="887"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2175666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="970" mass="106332" checksum="8DBC68563BB28C0F" modified="2022-01-19" version="1">MASTDPSAEKQEPKVDQQQSPAEKVDMPNGMTLTVEELYDKDKFDLSTMEPGDVFQLLQTTTEGLTSEEAAARIEKFGHNRLEHKEVNPILQFLGFMWNPLSWVMEAAAIVAIAVSNGFGRPPDWPDFIGIVLLLLANSIIGFMEERQAGNAVKALMESLAPEAKVKRDGEWKTIEAADLVPGDVVSIKLGDVIPADGRLVAAHGQVSIDQAALTGESLPVTKEAGDEIFSGSTCKQGEAQAVIIGTGLNTFFGRAAKLVGDAGDEMGHLQIILAKIGNFCMCTIGIFLVLELVIMYPAFKYDYRRGIDNLLVLLIGGIPIAMPTVLSVTLAIGAKQLAEHKAIVTRITAIEEMAAVTILCSDKTGTLTLNKLIVDKPTIKTYAEFNGDEIIQLSAYASRTENQDAIDFCIVNSLPDAKMARENMEELEFKPFNPVNKRTEITYKDSEGVVRRVTKGMSHTILDLCTRDKTEETIKALNDDVDEYARRGLRALAVAVDEVPSGGVEDEGKGFRLVALLPIYDPPRSDTKETIDRAIALGVQVKMITGDQLAIAKETGRRLGMGDNMFLSKTLKEGPPAGSGYADMDELVLQADGFAGVYPEHKYEIVERLQNMGHMTAMTGDGVNDAPALSKANVGIAVADASDAARSAADIVLTEPGLSVIIEAIIGSRQIFQRMRNYSIYTCSVTIRVVVGFAILCFAFQFDFPPFLVLILAILNDGTIMTISTDRVKPSPYPDQWNLREIFSYAIVYGLYLTASTVVFFAVMFKTSFFQDKFGVSTITDANDPVAHSVIYLQVSTISQGLIFITRSRGFFFTERPSVMLMCAFVIAQLVATFIAVYADWGFTNISGCGWSWAGIAWIWNIVWFAPLDLVKFAMQKVFEPKNTLKETGHAEMPGRRSRRSSAVSTGAASARYYANRTRSLKSLDQSRNFGKKLLGMNKKMDAKEMRRFSSVQTNHAAQILNSDSNARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PM01</accession>
    <name>A0A8H7PM01_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PM01"/>
    <dbReference type="OrthoDB" id="449091at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF4">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="854" mass="95685" checksum="DDFD9A36F8868D28" modified="2022-01-19" version="1" fragment="single">MQKPLQKLDPMPKLSRWQILGPFPAGMREQDFGADPLEAYGGIHNISYSETARYPSELSDGGLVGWQMLESHGSTVGPLVFPSTRWSMNQLALGWAVNQFQAWAVISFSLEREKSFRVQFHSIGDFYIDQDLYSGDWYNLKTTAHVVHLAKGEHTLRVRVVNEIRIFGGSTPPKSIFEYFWEEIESSIPAIAIEQQVNMPDIIDSRFAGHLCSIAVQNVLQKADLRVVAIQITTQSTDIAINASLRNAGEEAAIMPGQIRQIPFSISTVEKLPPTLSSIFIIHVTVEIHNENHTLPGVSFEIHHKKAENDAFRITFEDQDKSIQYAMVRSPKTLTFSPSTPPPILVALHGAGVETSSPWWTGALSRSEKAWASLLLLIRLLDRDEIEYAHLIQYYVYRPFTQPEEVHGDSIGTDQVCLMSLELLMLWSKICIFEGHSNGGQGAWYLGTHFPDRAIAVFAAAGYTKIQDYVPFTGWIGGSHSDPWLRGILESSIAEYNNDLHVSNLAGIPIHALMGGDDDNVPPLHTRKYARLANEYVADPEYVKVTEVPGEGHWWNKILDNEIYSTFIEQHVENPKDVINELEDFTVTLINPSGSGSKGGIFVEQLSTPYRLGRIHVKIVKDDQNVSTWYLTTNNIRRFRFTDQVLQRFSNIRVDGSIIASTSLHDGVFLEKSDGEDWKTVTHVSGLDSTNHGPLHRIYESRGPLVIVCPRGNDYYYHKALQIAHDWNLYGNGDAQIIMPAELGDLPNANIVFLGGPEENELTSMFLRDSLSDISITKQELRVGGHIYSTRGSGIIFHQLWRQYHMAIIIAGIDQEGFTSAVQLMPKRTGLIISDWVVTGPNMKWQGVGGIQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PM95</accession>
    <name>A0A8H7PM95_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PM95"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="320" mass="35643" checksum="237C4706665FEE2E" modified="2022-01-19" version="1">MDPSDQDFGSFVASYDGPDTDPPVRNAPVNPNNPYRQSNFMSFSATNAQPQNAGLTRRQTQTRPVNVQDFEQSFQSGQRPSIHISASQDNSRLSPIQDYDDHLSPPPSPGSPPFLARHNSFNRLTNTRNMSLSTFSGISNLDREELDESDTARLTTNAAGSMPVQPPSPVHYPQTPNYVESNPFGRPDSQSVPTIHTTHSLQGLSNILRRVSTRVVNLQNRRSRTETDEDIIHQHDPSAELLTPGERAKFGDDIEMTSVKDGERNIYPEYNYAEDKKITQTAANDSVDNPHTIRLAGNSCYLFGPDNALRIALAHILSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMI6</accession>
    <name>A0A8H7PMI6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMI6"/>
    <dbReference type="OrthoDB" id="2488381at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="449" mass="49457" checksum="AF9FC3A12BD1FAC5" modified="2022-01-19" version="1">MKSATFRYSLIKRLAVVTRPFGYATRPPHPCPVRPPKNRATPMAVDNPPLHVLMDVDPWWWGPDADSTLDEEASASPTVMDWEPGQKDRPPPVPVQRVRLTLPPASRHPNRPKLKPLRARREAVPQAAPFSTQQQAATSRAAGSSGRGMNCRTGALAQYQRSSSQQLVATEMPPPNTPVEVDRLECLVRSAQSPAQKAPSPFGSPRPRPRGLVAPTQEGLTQVDREMLSQLDVIRSAPSSPTPRPQLECHDAQVLQQQIQKIREEIALLEAEDDGFALAQPVLQCEDVLGEIQGEEMQEEHDPFSAGPRDPSQSERPTPYRLHRKCLSVHQYPSVSISAISSQFSAPKNAILYGASDAMVSLYHDAYGQMPRPALTPLRWPLSSGAIYGPREKTPGGWLFVPVPLDCVWTALPVTGFLALQNWTLAVFRDPGSLDAYQLLFCLPSDLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMW4</accession>
    <name>A0A8H7PMW4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_007666</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMW4"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="247"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="527"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="615"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="719"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="615"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="668"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2177012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="865" mass="97933" checksum="5230AD8E70E54D34" modified="2022-01-19" version="1">MDEANDSMDIHDQYTITSDDQHYEHDGSPSEPYSPPRPSREKKRVQKKENAEDFLFSRGGESIEGKAQQAEAAVKRTKDILHSLSTGIVEIPSGNQELHTFKLTNDSSVFGSHGAPHIWEPEPPLPISYNGPLTMPPKATQEILIQTYFEKRHNVFPVMPRRMFMQQISVKGYLITPLLLNAMYAHAAMHLNEEDPEACEPANVYFNRAKLLIDDYLDTPRVSTVIALCLLSLFEFKDPTQARFCRSWIYSHSAFRLCHGLGMCRAYTIGDRMKTNDIELRKRVFWGCYCLDKLQSIDTNGAWMIRSEEFEIDMPSFQPADFATEHETLEGFVAYIKLMQIAERVMHFESYQTKQTLVRTREHEQMLLSFNNDLLNWLRSLPPHLQWTPLPTQANATAPHPPANSIVSHVHLVYNAIELSVLKPYANSTNKLIQHRCHAVAENITQLATFLCEHRDFIATYRFLASALMRAAVVHMNGLEDTNFKAASRCKSLLQTSLKHLLELVQHRAIPNLDDFATALQTSLFAGQSPKSTGHEQHLNGSPQTRLMQHQPAIEMEDERSGRSMAYKGSTLRPGQKRSYSDRQASPSEHHESLQTNHLVLNDDEQRAAEVLSYTFQSQPSQITASSPQRQSSMRYTSGNQHPNNEYAINLVMGDHWPTSTPPPPPSITQHAPGTFSHSMSPQSNGEASNQATNFNPYNMPKISREHNQLVKLVPDHSNGQPVNHASGEANGNVDNRWNNTHPPNTFDNRHDSLLYSIAAAASNDVWTEQENDKWLSAPDIFDRSASQRSEEQSRMQTPQQQYMNIGLGVYASAHQHHTDVIRQHFMMTNDRNNSVRPVILTHQGNVVVANDNTITGLGRARTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PN51</accession>
    <name>A0A8H7PN51_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PN51"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="87"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="26057" checksum="DC95E2AD05650BB0" modified="2022-01-19" version="1">MTLKVVGAKISTFTRTIRLALEYLNIPYELLETLPHTETAYKYNAFGKIPTLIDGDVKLIETLAMKRYIDHLQQGNQTQGQSLTPNTLNEQLFVDQWISIAGDYAFRELIIAVSKPRQSMESQGKSETEITNNLESQLERARVVLGAIESHLASSASVGKSWLCGSSITWADLFMFPIFADLASLPERELIKFESPHLWKWFERFSDTDIAKQTFEGTVADSRSKQQSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PP38</accession>
    <name>A0A8H7PP38_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PP38"/>
    <dbReference type="OrthoDB" id="10343643at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="69" mass="8073" checksum="5529C2F246341FB0" modified="2022-01-19" version="1">MNSNTPTQDDTTIGQSHYNRALWEWTNNQLKQARRKSDEDYVRRSGYKPRTHQQQQRQATATQSSSCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PP57</accession>
    <name>A0A8H7PP57_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">COBW domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_003086</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PP57"/>
    <dbReference type="OrthoDB" id="258627at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="entry name" value="CobW-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF31">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="9">
        <location>
            <begin position="39"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="9">
        <location>
            <begin position="110"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="CobW C-terminal" evidence="10">
        <location>
            <begin position="299"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2177839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="40919" checksum="29635E51885E9A50" modified="2022-01-19" version="1">MQDGDFDDIPDLVPVAEETSGSKPHTEPVTNSAGQKKIPVTIVTGFLGSGKTTLLNYILTEKHEKKIAVILNEFGESSDIEKAMSINEDGALYEEWLELRNGCLCCSVNGLADPGPIASMFWLDDQLGSDIFLDGIVTLVDAKYIAEHIKDQKEDGAINEATKQIAIADRIIINKKDLLSDSEMDALQDTISGINSAATIVKTERSRVPLDFVLDINAYDITDADGVALQTNKINEISSTHHHSDTVSWFLSSAFRVFLLNQPIHNIDILERWIQTLLWEKTIPRADKQVFEQEEVSNDKQITVLRLKGIVTPTGSKERIIIQGVQDLYDMQPAIAADNVEESVGKLVFIGRNLEKSRLEASLTQWLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPJ4</accession>
    <name>A0A8H7PPJ4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPJ4"/>
    <dbReference type="OrthoDB" id="2374513at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="592" mass="66183" checksum="386D64AC252381ED" modified="2022-01-19" version="1">MIDEIPGMKDVLRLSLIQHRYLKHNLLSTESTEKSHPTATITWLNDYETDDLKEFDIVHTVEGLALNPSKEEAGILPITGTTQTEAGMTDNDVTSLSLPISLRLILLGEATDEVKEQIMSKLCQIDSIWFNDCSVVEATANDEAEPTGCAIQNSHHALDIKIIDCRYSATPDAIIDYMLERTGLDPATHPPQDRLEVVDLVLYFCDSDQAKLERSIKLLRILNGLQASILPICLEHETESNNHVNHSACQYALQNEDIAVLQRNDTWQTSSTDHADMLNVDQLINIDNQSIEELILAAYSAKASQCTAAFPSTPTLDLTPDVSETQSLDLSLEDESNSRHIGPFMLFAITFTMLTVLYGLISEEDSAKDKLSAKWLNMSMDTSEPYFQAKLNPMWTTLDPVDHTHYFVVELSDLTGYRLPNEIGEDEIVDAVVVKKSRVSDGLIEEYEVINVPHLERGLFGVQVTSPCYDESVEEVRVELWLSEYDMQVDGSPVTLSIDTCVEGRHGAGTRATETTTTTGFPSSQPRPTNPDGSSGGHIVFRSKKNQRKNRFYQRWFQSVETFLNSMIEYFIKAAFQPYTSLPQQATPTGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPK5</accession>
    <name>A0A8H7PPK5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPK5"/>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="115"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="528" mass="59313" checksum="E1569FAAE5DC2B72" modified="2022-01-19" version="1">MFLNRGRLTATRSQRALLHSQAKKKATSAANVSLLPLLGTAGAITVAATLYHSRPALNEAVKTEDGLPIKKVRLFQTAIDRYDNRPFEILPQKSIDGIFRSGEVAYKFAQPIKYVSGVYVNSLRSNDPIEDHYSVDTIGSDKLIAGVYDGHIGPECSKLIRHKIPIYVAQHIEHLPLTKSVDKVMGAISSAFEELDNHIQQRFLDLFPKNLSKLSAKDIRGAIANRKDQKETRKIIEEAIHGSCASIAYVDGKDVYTANTGDSRSVVVSVDKDGNWIGKRLVEEQTPARPAWRELMESQHPASETPGLIRKNRVFGLIAVGGAFGDIMYKVPVEHQTAVLPNIPADIYQRFARYHHRIIANYRTPPYLYSKPIVTHYEMQENDRFIVIATDGLWWFTGKEDEHSADGDQAVADIMSKWKGTGEAEEVNPATHLMKKSFVQRRIYDFASENSKGNFDEAVEVSKLLTKQPSRHFRDDITIIVIQLHVNQNSEKKDPSLYGEVIEARQVDVKSPKIYTKAQTSWASWFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPV0</accession>
    <name>A0A8H7PPV0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS15 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003482</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPV0"/>
    <dbReference type="OrthoDB" id="623277at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2178229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="151" mass="16940" checksum="3C496C5DEE145794" modified="2022-01-19" version="1">MGRMHAPGKGISSSALPYRRTPPSWVKTTPEEVCEQIFKLAKKGLAPSQIGVILRDSHGIPQVKGVTGNKILRILKSNGLAPEIPEDLYQLIKKAVSVRKHLERNRKDKDSKFRLILIESRIHRLARYYKTAGQLPPNWKYESATASAMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPY4</accession>
    <name>A0A8H7PPY4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Chitin synthase</fullName>
            <ecNumber evidence="2 7">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_003375</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chitin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 7"/>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPY4"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF44">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="578"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="657"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="760"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="801"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="9">
        <location>
            <begin position="68"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2178122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="829" mass="94341" checksum="981E30AC222C8C1D" modified="2022-01-19" version="1">MSSNPLLPTNNHNPPYIPYAPPKNTRQVNWSNNANAYDHPLNRQSPEHHIPVSSTPPPRGISKFNRSKSVRHVKLTQGNLVLDCPVPDKLLRNVKYSTGEEFTQMRYTAVTCDPNEFVKNRYTLRPYLYNRQTELFIVMTMYNEDDQLFLATMNSVIKNIAHLCSRSKSKMWGPEGWKKVVVCVVSDGRLKIHQRVLKVLGAMGVYQEGIAKTTVGDKAVTAHVYEYTSQVVVDRDTGKLGGSDKGTVPIQILFCLKEKNAKKLNSHRWFFRAFAPVLNPNVCILLDVGTKPSGTSLYHLWKAFDRSKYIGGACGEICAEVGHRSRNLLNPLVASQNFEYKMSNILDKPLESVFGYISVLPGAFSAYRYKALKDTAPGIGPLSSYFKGETLHGDALNAGIFEANMYLAEDRILCFELVAKRGEQWLLKYVKAAKAETDVPDNLSEFISQRRRWLNGSFFASFYATFHFWRIWTSGQSIFRKFFLMFLFLYNLVNLVFNWFALGNFYLTFFFLTKASVPTKIEEMVNGTLTEVVQKTTAPDPFFGQGDVIFNVLREAYIMVIIIIVISALGNRPQGSKFIYMTCVFIFAILMLVMLYVAVFTIYQTVPKTAQGWENVGSLLQTSPAFRDIIISLGSTYILYFVSSFMYGEPAHMFTSFIQYLLLLPSYVNILMVYAFCNTHDVSWGTKGDNTAESLGAAQVSANKEGHQIVKVEVPTEKDDINERYEDFLRTLAVPEVKQKSSRDAKTKMEDYYRLFRTRLVLCWMFSNALLIVAMSSSAFIQYMETHNPSPDQAYNPYLTFIFWSVAGLSSVRFTGSTLYLLSRFLDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQ25</accession>
    <name>A0A8H7PQ25_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQ25"/>
    <dbReference type="OrthoDB" id="2376782at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="445" mass="48549" checksum="9A28F6972C078104" modified="2022-01-19" version="1">MSQRDYFPQREESFSHGGQCDNDSNSQRRTSYYPMPTPASDHSRTNHSFSQTGMYPYHGDNNADPNAFQTPYQAHQSIPVSNYDGHGQSSSDADPFAGQYPPPRQPSGLNQAPHAVDPVYPAYSPNEYPVNGNFPMPKPYQKPAAANDDQATVHTANSAHTRSSAPSMTNSNSYTRQNSSHDGHDTSNLMAGAVGVAAGAGLVGALNNKSTDKGYYDPHAIPLNEWQQAERTNTNPLQEYDLRNNAMTPDMADPSNGREAYMQDMRQQPQPEPLYAEAGYPTVAPPSYLRPDRDGYLPGARGRTPKQRPAGAVVPQTPVQNQHYPLPPPVQPYQPQLMPPPQAYKPPRDSRGGCCYCPALTCCSFFCMLISVGFLAAGIAMIVYAKVASEQCPPCDSKSSLSGICNACNSVLYDGLFYGGIVVAALAGIGIIWRLFMWCCSARRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQC0</accession>
    <name>A0A8H7PQC0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_003486</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQC0"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="357"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="593"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2178233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="730" mass="83385" checksum="ED8D1FD493AD7468" modified="2022-01-19" version="1">MLDNDSKADTTADTASQTQETMALAYQEQVTIRSEPQSPEHAIAKNEKTPLSESFLPETVITTPDEGGTSENENFETPKDASAIQSVYTETEDDFESAEEYEPSEESAKATDGVVKNRKRSNISQRSSTDATVDIRSSLSSTFERLHETDELNSGESDTSATTSVSSPTESYKPESDKENSDDSPVNEIDPRSRKVTSLPPQPTEALRVSMEGIALPSKSRKMRLDDHKKVKGFAKHFSFPMNPFAKSPEQPVSDDTPPKRPSELYQKRMKKMSSDKQRARESITSIVSLRDMLALKGRTSEEQHSIVFGELEKLKHEIDGLFLTRQLADFWASVLVDYEKINKSNSKLLSEHIQLGIPSSLRGMMWQLFSGSKDEELEERYRELLDETSSHEKLILRDLARTFPGHQYFKERGGAGQEGLFNVVKAYSLYDPEVGYCQGLAFVVGPLLLNMPDEEAFCVLVQLMKKYGLRGHFTPQMEQLHCRLYQFEQLLLDKLPHIYRYLHEQGIRSTMYASQWFMTLFAYKFPLDLVFRIFDIILAEGIDCIFKFALANDDRRLVYDACSISLNQKKLKQYAKQHDVLMVKEQQMFDKQETLRQSNRELMETVQRLEKSIMKLQQDHEEVASQVITSKIDLARMDSENSELRNQNSILRRQLDELPAEIEGKWTVQFDTLCEKNAGLVQKNSALEDKLTAQEGILIDFKMKYAESENDNESLLKQLNQLKKITSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQY1</accession>
    <name>A0A8H7PQY1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">E2F/DP family winged-helix DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_001675</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the E2F/DP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQY1"/>
    <dbReference type="OrthoDB" id="429183at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000008">
        <property type="entry name" value="E2F transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF18">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="12">
        <location>
            <begin position="243"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="163"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2178829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="422" mass="47208" checksum="AA61125CB9E00401" modified="2022-01-19" version="1">MQIGIYLDMVRCDQKPGQPVHIFKIPHYTIFDSGTFESGISDIGKINALTSLEEVCPSQSLIILEYAINSAMVLEVLLRVLANGRAFFHSFYSAIDAILLLLCIATLVLITTGCSNTQRDEAIVDTILLTIRNTVQLCRFAAMMQRNKRTLDSRAAKVDFTGLNHQPSQSSLAPSQFAADSEDDDGVLRPSRSSLQFVPSKPYDIPDNGERPNKRPSLLRQTATEQNESSMSAQSVYQSNCNRQDSSLGQLTRKFIALLRADPTADLDLNVAAVQLQVQKRRIYDITNVLEGVGLIEKNSKNHTTASTEYPLTQFLGFVSQDADPDSPFPNKADDSLHLEWLRDETSRLENQNCTFHDIEADIDHRTQRLFDDYGRYIYLSEADLLQQLRPPDNHMIVATNTPHNITIRTSTDDVSAILLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PR62</accession>
    <name>A0A8H7PR62_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PR62"/>
    <dbReference type="OrthoDB" id="2345540at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="34100" checksum="6A36DD87EEF97D18" modified="2022-01-19" version="1">MNSLKEWFLIQSVLDGSSTLSCDRTPLDDYTRSQVYVYPTPEYTDAELWRWNGNYLQNKKSGLVLDIRKGRLRLIEDTEICLFQAKSLDDAGNQQWGIRSSRDEYGRETPGVFIYTLSNEEWVVDLNIHSAGSANGAKLVLYPAKDFDNNNQLWAFTPAEIALTTPDTSPTANTETNDDDILAETRRRSQSSTNSQSAEMTLETLKECHHKAYLENDPHLSNRTIGMAAAYYTIMQWKLSAGKPDPALFGNSISNELQWLQAFAAKQASSLFDKSDTLSSDRSTAAKIAVKVVTQLHSQLPLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRE0</accession>
    <name>A0A8H7PRE0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Charged multivesicular body protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRE0"/>
    <dbReference type="OrthoDB" id="10266568at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2178902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="47466" checksum="688A321BD658C9AE" modified="2022-01-19" version="1" fragment="single">SMASTMNSIQRFFGKKTSEEMVKKWQQDIRAQNRGIERQIRSIQREEDRVKLSIKQVAKRGDTKSCKSLAKELVRSRKHKDRLYTSKAQLNSVSMQLSHQLATLKIAGTLQKSTEVMALVNQLIRLPEISKTMQEMSMEMTKAGIIDEMIGDTFEMMDDEDLEEEADEEVNKVLYQVTEGIVGTLGEATSVANLKNPVIPAAEEEEEEPELDMMQKRLEVSYNYNLFQLKFTSKQLLNQSKRATKDENAEKTKLKTAIQKGNMEGARLHAANAIRKKNESLNLLRLSSRIDAVASRVQTAVTMHQVTGSMANVVKGMDKAMQSMNLEKISMVMDKFESQFEDLDVQTEYMEGAMAGTTTMTTPQTEVDGLMQQVADEHGLEMNQEFGNYAPGTSIAGLNKQEEKDVEADKLDERLRALRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRG8</accession>
    <name>A0A8H7PRG8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRG8"/>
    <dbReference type="OrthoDB" id="10573734at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="178" mass="20489" checksum="D96C0C6EA0039905" modified="2022-01-19" version="1">MGNQNSSYLNRFRRGGQRYQNQGYPNQGYLNPQMVEQQQMMMQNGIPSMAPPMGEENSGMMQEQQIEQQQMEEQMEEQMEQQQMQQQQMQQQQMQQQEMQMQQQMQMQMQMQPPMMNPMYSQMMPPGGGPGFMMIPPNMPQAGPQTWQLGGSRVVVSQGLVVVDTSAGWQNGGTFTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRN4</accession>
    <name>A0A8H7PRN4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_001861</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRN4"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="4">
        <location>
            <begin position="80"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="2">
        <location>
            <begin position="80"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="208"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2179012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="266" mass="29996" checksum="B20958CABF3629C8" modified="2022-01-19" version="1">MRATDTRLPTLRPILPLPHNKWPNVDQPNLRSSPSPPGTPPKPSNFASTTSTVPLDISAWSRAMESHNTNSKKLKRKRRSPPFSYSVMITQAILSSVNQRMTLRDIYLWISSRYPNLYASNETGWQNTIRHNLSLNRTFKKVPRRESGLPGKGGFWTIDFQYFDYESFRQKSGMDLTPDKEKTLSYTTRALGQQQLINEMQNYEASSASDASYTAHSQTSSPNGSISDYSLSPNNTSNDPLGPLASDSEYSAGPRRESMNIRNLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRX6</accession>
    <name>A0A8H7PRX6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_003379</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2354469at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025151">
        <property type="entry name" value="ELYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13934">
        <property type="entry name" value="ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="280"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="130"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="644"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1424"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="644"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1424"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1444"/>
            <end position="1471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2178126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1516" mass="171418" checksum="0DA79751FB9FCD69" modified="2022-01-19" version="1">MTKKRGPKSSNNRANLPPDARTRHEYDLSGSPEDSSHNSIAQYRYRVANSCPAIINVIGNLVFSLDSTTDQHTLPDQNDSYIDDYETEKVKVHYFRYLGRTAIGESSLSPWDDHQAPGLKRIAVTLRLRRPRKQTTASNNSHLTSTHASLTPPSQLQYSQLSNESDNAPSKSLIRHLIDLYYTYASFMFPWESKSAILSDMEEDAASACLIYCMCAIGARYSTHREVCTPGKERYAYGEPFADRAKRLLIPLLALPSLEVVQSLVLLTYQEYATDRDSGLWMYSGMAIRMVQDIGLEKEPLPVQQEQSNQSSDPVTHNERQSALPTFKNEREREIRRRVFWTVFFLDRLGSIGLGRRFVMWEDGIETAIPSYNADLDDNLWLDSKDSTDGEDHLPLPYTYVAQMMRIHGNISTVLNFCEEPDKRLVQLKEVLEQLQEFNKQIPAAFEFTVENFQIYSSRSLAGAFLLVHFWYHALIILINCPTFLTTNLHPKLPNLENWEQAYSSAKAISDFLSYVDLLNSSAYLANPFINQCIYLAACALVQKIRKRLPNEQPLQVYNTLPFNERLDVSSDQASYEICRKALHRMQSYWLGMNWTNVSLEQYSRGILDIDLCINDNNKDYKEGNIPLLDNGLLRKLRERECNDGKVKGDSKRRASESTDIKSPQEERDKKRQPPIDAFSISDYTESLKVLPVHADVSSGQKMDIFDDPCVVEEVVLSDLAFTNPLTAEDESLLDLISNSNMPDDFLHQTYIPVSTEIVPYLDSFIDADPKESRFIPDNLTPRLSLEPNIFYRHDSTTIEAEILAAANLILNEQYYLAIIIRDKLSTGSYIVLWNFTLSEWEFHQLSTSIQGSIAATGISVNAFPISSEASDAASRKAHHLMVLGTETSELHFIDISMIDKKFTIISQMTDFSGSEPGVHSIYILSSSMADQHAMDPKVYVGAAGVLRVFKYSLKDQKQFIQTSHTFSDLLPTQDPVTHINCFRLQDQQKTIIIVGQSPIGQSTSSSDKSAKISVFQTLANGDRSLLESWGAPTTNQQKSKESELLTLRTIFPTESNTSYYLLATFATHTGSGYSTHILAIEFNRTTFKEVYTLDATRYCFGAPVQDICLVRGDAQILLLLGKKLVRFNALFNVNQQLEQPIDYRSSTAFGPVEDAFHFSNSQFKTWYNSQELAAIQSQRKKMHGVLFFDKALTFAKINASAYPPSSSKKLKNLVADLHHCDLDTLRKHSLIYYLLLDCKNASHTRYARRYSIPLGVQKLMDAYWFLDHGQYEDGVRLLSDPGVEVDWTDKIVQTLYDLASPRLALQYITTTKHQLNSTDDIILRMKLLCNCSCEGAFLFQREICADRTDNLQGILMQIYLDNIFTVQYDQDELESTIMKLRLTSREAQIFMVYLKKSVHPASKVCLMRYVAARGRKSTALENTLSQSSANNMDHTPSLPRSDPVNSMQLQEEASATTPLSNVGSEALSSRNGELSTMDAAENGAQLGKAFFISALASLSRKRKAADVDGDIELIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRY5</accession>
    <name>A0A8H7PRY5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_001671</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRY5"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF1">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="79"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2178825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="368" mass="41698" checksum="490346027152D647" modified="2022-01-19" version="1">MTDESDAQSKSMRKPSRNDSSRKPKLFRCTGYGNCNMVFTRSEHLARHARKHTGEKPFQCVVPGCGRMFSRFDNMMQHTQTHNNGKSTRRTKVKTKKRPAKRDSGSSTSTSMSIHKRNHSQSSVTSSPYDMSSDESEYTPYKRPRSGAYRRDSTGTHRSSYSLDDSPPTLPPPSYITHETIPPVEHLIGSWHSKSQNSASPPSPLAPLSPPMSNESPTGYLALRSWRLPIASSWRRKSLEGHQPLSPLSPMESDFSILPKLASYLVKNPDKSPESFYRRHRSMDDSYTRRDIKKEHDRYSTRRLSVADLCNPIESLCQGSDWANTKPEEKTISLTEDEFEALQGFSRFRLGSTSQERHSLHPLSSSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PS99</accession>
    <name>A0A8H7PS99_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Glutathione S-transferase 3, mitochondrial</fullName>
            <ecNumber evidence="15">4.4.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Glutathione peroxidase MGST3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">LTC4 synthase MGST3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">INT43_001839</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione</text>
            <dbReference type="Rhea" id="RHEA:75963"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:85236"/>
            <dbReference type="ChEBI" id="CHEBI:194498"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:75964"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>leukotriene C4 = leukotriene A4 + glutathione</text>
            <dbReference type="Rhea" id="RHEA:17617"/>
            <dbReference type="ChEBI" id="CHEBI:57463"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="EC" id="4.4.1.20"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:17619"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="14">Lipid metabolism; arachidonate metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Lipid metabolism; leukotriene C4 biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.20" evidence="15"/>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PS99"/>
    <dbReference type="OrthoDB" id="410651at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004464">
        <property type="term" value="F:leukotriene-C4 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.550:FF:000004">
        <property type="entry name" value="Microsomal glutathione S-transferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF26">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0564">Palmitate</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00069748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAG2178990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="145" mass="15602" checksum="DD0941B027F57220" modified="2022-01-19" version="1">MVAITIASEYGYVIATGIASSLMVTYLGIKVGGARKAAQIPYPYMYAEKSESEKDHKKNVFNCTQRAHQNTLEGYPMFLTLLFTGGISAPVVSAAAGVVWILGKIVYAQGYSTGVPSKRQRGSFGYLGLLTLLYTSGLSAYNLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTJ2</accession>
    <name>A0A8H7PTJ2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_003715</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTJ2"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="93"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="291"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2179928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="341" mass="37809" checksum="D7ADBBDD025A23DC" modified="2022-01-19" version="1">MRFSTLTRRKKHIFLSYLKDWILVIALIVIFLVIDSVDPFFSDFPLQNRRLMYSLKDDTITIAELAVIAVVAPFVIIALVAIFLYRSPVDLHNGTLGLLVSVSFTLMLTEIMKLTVGAHRPDFLAVCAPKAGAVDPALALSNVSVCTRPMNDYLLKDAFKSFPSGHTSSNILLTPLFGFAGLVYLSIYLAGKLRLFVVKTGYFYRAFICSVPILGAVLVGVSRIRDYKHHTWDVVIGALLGIIFANFAYRQYYPSIFSPHTGMPFEPRISKPNDATTGDSASISQRLGADYGLDDEDPQLGYSSATSPQSIELMNARKTQRNEQSIQRNEQSSESTSGMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PU66</accession>
    <name>A0A8H7PU66_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PU66"/>
    <dbReference type="OrthoDB" id="10302760at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034083461" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="12842" checksum="C33E0D9C2A7A16B2" modified="2022-01-19" version="1">MKISILSVFLLPLGIVMAQDGNGNACGIAQSFECEWFVRLGGRTCTQSERTGSPLAIASCIKFRALRGVLCSNNGDGLIGDYFGTQGVCQGTGFIQKNAERLDDKWIQVMKNEACSATGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUI1</accession>
    <name>A0A8H7PUI1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">6-O-methylguanine-DNA methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_003891</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = S-methyl-L-cysteinyl-[protein] + a 2'-deoxyguanosine in DNA</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUI1"/>
    <dbReference type="OrthoDB" id="2396089at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815:SF13">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="12">
        <location>
            <begin position="74"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2180103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="186" mass="20350" checksum="7F8258CFF139EE77" modified="2022-01-19" version="1">MAKAKTIPAKSLQAIQESKAPVNKKAARSRVGKLPDARADVPFDDDVAELKIYPRTVEDRAVYINPKTNRKLTEFQFKVLDLCAQIPKGKVTTYKKMADAVNSSPRAIGGVMRINPFCPQPVPCHRVVASDGFLGGFNGQWGAGGNMRNKRAKLEKEGCKFNADGFIVADKSGDFNVFGDFDTSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUV7</accession>
    <name>A0A8H7PUV7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUV7"/>
    <dbReference type="OrthoDB" id="2189509at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031537">
        <property type="entry name" value="DUF5092"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17010">
        <property type="entry name" value="DUF5092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2180298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="354" mass="40798" checksum="7B9F23E359BBA518" modified="2022-01-19" version="1">MKDPDSPSSPQLIFKRDSSESSHLSLSTTDAFSLNTFHELIDEHSKLLVDEKSAERRCLIIARVKTRDASAERYFNSYYDAWHLNKILFRAQTSSNRSYIHRLSVADPMTNSKIVSVEYFLVGNHLENDFKIQEAHYREHESVYDFSHQVPPAFNGYSKLIATFKHDEDNNLYDMKDYIGSRQAAHSLSKDCSAKKLPLSYSSHFIANYIGNDIDYMRSSALRTCFRTNAISVEDAELFLLQPQQPSNFWEERDWTRFLVPNFNHQRTIQCSPVDALIQAVNVLFCCVLYYVEIEEDEYGLEAEYGLEAEYGLTQYDDNSANHASTNAETTTHDHWQPVTAVNDLTLTYSTIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVN1</accession>
    <name>A0A8H7PVN1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Uricase</fullName>
            <ecNumber evidence="7 10">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_008506</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 10">Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>urate + O2 + H2O = 5-hydroxyisourate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:21368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="EC" id="1.7.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 10">Belongs to the uricase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="7 10"/>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVN1"/>
    <dbReference type="OrthoDB" id="9992118at2759"/>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.270.10:FF:000001">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.270.10">
        <property type="entry name" value="Urate Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019842">
        <property type="entry name" value="Uricase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874:SF1">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000241">
        <property type="entry name" value="Urate_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00366">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4 7 10" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2180926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="299" mass="33853" checksum="AD722B7A50C13D45" modified="2022-01-19" version="1">MSTATLKAACYGKDKVRVLKVYRDGEKQTAVELTCRLTLEGDIETSYTKGDNSVVVTTDTCKNTIYIMAKRSANVDNIEVFAQEITEHVLRQYQHIHVAHVEIIKHKWSRMTVDGELHPHSFVRDGEEVQTTKVSHHRQGDKVQIVSGLKGLLVLKTTGSAFHGFYKDEFTTLPEVWDRIFSTAVDCTWTFEPASPSALRQINFQDIHQNIKKITQDIFAKDDSASVQATMYKMQKTILDQHEPIAEVSYVLPNKHYFGVDMSKFNIDNTDANLDVYQPVSDPSGLITATVARKSRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVQ3</accession>
    <name>A0A8H7PVQ3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVQ3"/>
    <dbReference type="OrthoDB" id="2290708at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="419" mass="47778" checksum="9B60678AB8E8C448" modified="2022-01-19" version="1">MDPTPSTSPNLLEDNLASRQADAIEAGSILISLANSHKPSKDHQELEAAAIAMESMSKHHRNHSVGSLYSQPMHNNEHKKRPSSSSMSIHNLLSEDRPSASSSTQPESPDITPMQEMSSYRASGFSGRKPRGHYQTSPPATYKRPMDNDNYPMPNKRSSISNNVDHSMPPRYAPVPEYDHPDTHNTTYQNGRAVYRNSQDDPYRTRKDHRFNYDAYHYDHMTQASNSSQQRQFNNHIGAPPRSRKSSMSAANHTQKYYIMKQSPKVKRNAMHAYISYTIYMDITRRASLKNQMISDDQIDRGHHFQHPQNSPTPTAIYNHGPDRNRKYAQPSYNRSPAPRNEVTNGNGDDSEYGNGRRRGSMTFTNMYPSPHPHEHYSEPAQPQSHYRSPALEPSYLPQELLAQPLTAYLRERNNGQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVX4</accession>
    <name>A0A8H7PVX4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_008900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVX4"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="3">
        <location>
            <begin position="121"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2181317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="584" mass="64634" checksum="1D3CBB784EDDD3C8" modified="2022-01-19" version="1">MRFLPWLQTVFTTSLLYQSKGPSSDLRGCRCLPSDACWPSIDSWNQFNSTIDGRLVAVSPPAKPCHDPDYNEADCRNVHENWNDGYWRAAQPGGMITSNFEVQANETWGCPLDADPSSACTQGNIPLYAANVSSAQDVQKAVMFAGKHNLRLVIKSSGHDFIGRSTAANSFSIWVHHLQNITLHDAFIPTDVFAKPVTAVTIQSGVSLVTMYDALAERNWVVVAGAATTVAGGGGYIGGGGHSFMSPTYGLAVDNALQFTVVLASGEIVIANEVHNRELFWALRGGGAGTWGVVIDVTLRTFPGPKTISRAIYIAHFRNNKTFRKVFDKFVELQPKLSEEGFSGYWVAFNNTLIVEYFGMEFGWLTSVKKLKPFLDYSLAVGGPPLVFYDTDFPKWHALYRDTFCKFGNCRSDASAPQMIASRLIPSTAFSFSCHHELSTLLADTIDQFTEPKQVMLGHLVAGGMVSKKKPHNVAANPAWREALWHVVITGGLHPMNITAAMKKEYSDRLTRLNKKIIDFTPGSGSYINEADPQEPNWQDSFFGSHFERLKRIKNTVDPHHLFICHHCVGSEDWDGSLNCPRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWB3</accession>
    <name>A0A8H7PWB3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL14m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_008642</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWB3"/>
    <dbReference type="OrthoDB" id="274765at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000005">
        <property type="entry name" value="50S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_uL14_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2181060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="136" mass="14905" checksum="EAA574BD950AA5CC" modified="2022-01-19" version="1">MIGLKGTMSVIDNSGAIIAECIKVMSGGRYARLGKRHTCDEVVCVVKRARPINPSLIGTQAATLKVKKGDVRHAVVVRTKKEVGRPDGRYVRFDDNACVLLNQKKEPLGTRVLGVVAAELRQKKWMKLVSLAPRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWC1</accession>
    <name>A0A8H7PWC1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_008657</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWC1"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF565">
        <property type="entry name" value="AT28366P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="73"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2181075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="389" mass="42687" checksum="0AC784F6C2735344" modified="2022-01-19" version="1">MGQTLSEPVVEKHTTSGGDSRVIYGASEMQGWRITLPNIGFISVSVVVHSTIMSVVCSSTPISFKTAIGLWKSCDPRSLNYWCLATLFADFHHDVHTFNRNYSGAAVAKYCGQNLHKKVLADPSFAEKDYKTALKDGFLNIDQDLREDKEFANDSSGCTAVVALISEDNRVLVSNAGDSRAVISTHGKCKPLSYDHKPVNRTESSRIVAAGGFVEFGRVNGNLALSRAIGDFEFKQNSSLPATEQIVTANPDIIEHKLGDEDEFMIIACDGIWDCKTNQEAVDFVRAGLGEKKTVEEICEELMDDCLAPNSEIGGVGCDNMTVVIVGILNGKTEDEWYNWMASRCQSAIAKKAEQDKAKQNELAQDQNQDQSDVSIFYFPSSQAYAFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PX90</accession>
    <name>A0A8H7PX90_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PX90"/>
    <dbReference type="OrthoDB" id="2404892at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2182309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="105" mass="11447" checksum="DB44098811239E2C" modified="2022-01-19" version="1">MNIAKTTTVFRSIVGTAPRMVVRSYSMIPSTPHHKAEGVESLSESGGDNNAFFLKSMYERDDSRGSPEDHHQTIGSQSGTQAHQVQASQGSHESLAPRVNTVFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXD2</accession>
    <name>A0A8H7PXD2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_006939</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16305:SF28">
        <property type="entry name" value="GUANYLATE CYCLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16305">
        <property type="entry name" value="TESTICULAR SOLUBLE ADENYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="333"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1695"/>
            <end position="1793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1702"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1713"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2182013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1793" mass="201781" checksum="AEF19DCDDB217EDA" modified="2022-01-19" version="1" fragment="single">LTTLATQRGDSGAEAIALEVGGYMGECIRIIEFYGGDVVKFLGDAVLVSFQPNMQDISHIATGEPSAEDGTGESDSRTKTILVRRALECGLQLLSRLSHYRVYLTAEERSRHRDVEDELDGKVGPDYYARTATMNGNGEARQPSISSQTNLGIPLLTNTYPEETSMSFSIWNILSFLKPKRKPVGSRRTSISSDSSTRDLNSVDLELHIALACGEVTNIVIGDLGHQDSIQHSSSLKSARARKRISRLSRIGEESFEYADINDREGDEEQMRFQRDGRLEYAICGEAVEGLDEALAVAKAGEMSITPQAWTLINPQSLDLLWEKRHEFIIVRQPPETVPSGKKASSGKVTNKSNGTNTSSERAADRSLPLSITSKLNLEPLIPKVRNTSFLDLPTEVNPHYYKYLNRSALYRLRQSDDGNFPAQFRDATIMFISLGRLKVWTDDGIEKAQTAMTSAIKCLVKYEGMLQQFAVDDKGATLLAVFGLPPLSHEREAVFAAKAAVDLREEYMKEGFDDFAISLSTGLIFNAVLPQGNPFRRDPGISGDTIVMAVRMLKFDFAIQNVVCDLQTKQQIGGLCEFEDMGENYVKGKAKPLQIFRIVRFGEEKNKRISSMGVEKSSDFIGYKKELAKATNFIDEWNVAKNQHVLIVSGPSGVGKSYFCQAIHKLIVGYGVYSCWSTATEVEKSTKFYVMKNILLGLFDIIEQEKIPVSQQTRSIQALKDNLSVPSATGVRLSSYHSGSVGPSTNQLSTITTNQSTAPNFIPLQPMSTRDSQMVSMSRSQSTSTAPNTGTTGEWYKLKTMHSARSPGSASQQARNELSNELIELILKCLRKTGEDESFLPLFKGVFTALGDVEENRYTRKLDGRGRDIIFSGLVVRMIRYVTEYVSIMIICDDVQWADSASIRVLETIHDACPRALMMLATRPIKDYNVTFLKELCSFGSCAQITLNGLNGEEIGEIIINTFQSGVKRVSPEIIRVIQNRTGGNPLYVKNMAIVLKDFNHVTLVEGELVPSSNKFDLEDLLGNFDYKRIIKMQFDRLHVDYQEFLTVASCLDQSFGLNEIKAVIKSSNSIFQHHDNAKICRTIKKYDVYNFLIEIEGSTIADTNEDAFQFAHVTIPQSIYDMSPYEKRISLHKALARYYESQLTRDNYPQLLPKVTRHYLETDWYGKQLYYLEALADVNMRSYFLAEATSNLERMVKILDENEQLADEFGRMHRSDIYRMLGMCLTMRTKLTEGEHYLFLALQCLDAPWPRSDLEFGIKFWRNRFVQYRHRKYARATMIIKPLKERKAQAAQRIVEIMAQLSNIYFYTGKGRDFIYSCLIGLNACERLRDTGPNYSLFLARFSLICWLNDQKENSIFYITKALQQLEEKADAGTFTICAFLCFAAGKFENARNLLYQSIQVVKVFGVVTDCQAFYRSVGLAITMRIFEGTLDQSQTELALLKQMADTAHMNGDYEAEIWLSVYHICNGIVVDQIRDCEPFVVLVEAHLKQAADYNKIAMHGALIAYYARSGRYDLAKRHIRYLNAVLPTLTVTANIFPIFGLILATMGFYEIIEDSQASLLGGNDAQSFEKFINGIASLNRAFQQVKFWEFTQPCLFLARALPYISTGRTVEGFLVLRHGIMDMHFIDEVRFLKAYFWAKLGKYAFTPEDRIEWTRRAEEEFNEIQIHPDAYCNPNPGEDLMLDFLRRHSSTTTGRSLHRAGEDRRDSDSGESNTAVVTQETSDCGTHTITTDPHYPTSSEWDEGSSIPDGISDPGVGSHKSSGAVEEPKYNPKPVSEMQGNGKVVGVNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYA4</accession>
    <name>A0A8H7PYA4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Presequence protease, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pitrilysin metalloproteinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_007393</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running. Preferentially cleaves the N-terminal side of paired basic amino acid residues. Also degrades other unstructured peptides. May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer and homodimer; homodimerization is induced by binding of the substrate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M16 family. PreP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYA4"/>
    <dbReference type="OrthoDB" id="10250783at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000013">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000009">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000011">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055130">
        <property type="entry name" value="PreP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF13">
        <property type="entry name" value="PRESEQUENCE PROTEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22516">
        <property type="entry name" value="PreP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="17">
        <location>
            <begin position="493"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="999"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2182463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1019" mass="114155" checksum="D22AB90CBABC3091" modified="2022-01-19" version="1">MLSQCNLAARSVARTAGFRQVFRRAYSKSVVLKPGDQLQGYKVTETRTVPELQLTAIQLQHEKTGAQHLHVERDDTNNVFAVGFSTPVSDSTGVPHILEHTTLCGSQKYPVRDPFFKMLNRSLATFMNAFTASDYTIYPFASANAVDYANLRDVYMDAAFFPHLRKLDFKQEGWRLEHEDPKDKSSPIVFKGVVYNEMKGQMSDSSYLFYQRAQQHMFPGTTYENVSGGDPKNITDLTHEGLLNFQKTFYHPSNARFYTYGNLPLEEHLAAIDAQIRGFDHIDVPQVNKLAVPWNSPREFKLPCAADPFGNSDKQAKLSLSYLANNSTDVFETFAMRLLSYLMLDGHASPMYKALIESGLGAEFSANTGYDSSTMQSCFSVGLQGIKSDDIDKIKSTIQDVFEKAHQEGFDSNRVEAALHQMELSRKHKTANFGLNIMHGVSSGWFNGTNPADLLEINTYIDRLRKELAEGNFFESRIEKYLLNNKHKLTFVMEPSAQYSTELLEEEQSRLADKVKTLSEEDKQEIEERGLELLKNQDKTEDLSCLPTLNLSDIPVKGKRTPLEHTSVGETPVQWRTAATNGITYFRAISTSSGIPPELRIYLPLFCDVQLQALTSLGTKSKDMAVIDEEIRLFTGGLRASTLISTSHSDLEHIEEGIALTGNCLDRNLDKMYDILSTLVHETNFDDVNKLRTLIAMNAASMVNIVAEHGHMYARQYASSTLTPAMSHAEVYGGMTQVDFMNKLANTEDLSDVVSKLKMISELVLKQPTMRVAITCDEEVVAKNEQILTKFLSSLSKDSISLPSEPAVFVPQYGKTLFPLPYSVNFTSKVLRGVPYTHADGAKLQVVSSLMTSHFLHREIREKNGAYGGGAQYAGLNGLFSFYSYRDPKSLETIDTYSKAIDWIAKRKFSEQEMTEAKLSIFQGVDAPISVSKEGLLQFTDGISDDLRQRRREQLLNVTEDDVKYAAHKYLAEADVKQHYSLALLGEKNDKITSAQGWDVRSWGEATPSSTGSEPEVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYZ5</accession>
    <name>A0A8H7PYZ5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyldiphosphatase</fullName>
            <ecNumber evidence="6">3.6.1.43</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_006304</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a di-trans,poly-cis-dolichyl diphosphate + H2O = a di-trans,poly-cis-dolichyl phosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14385"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="EC" id="3.6.1.43"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the dolichyldiphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.43" evidence="6"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYZ5"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047874">
        <property type="term" value="F:dolichyldiphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03382">
        <property type="entry name" value="PAP2_dolichyldiphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039667">
        <property type="entry name" value="Dolichyldiphosphatase_PAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF1">
        <property type="entry name" value="DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="50"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2183299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="218" mass="24663" checksum="7374E88BC196635A" modified="2022-01-19" version="1">MAGIPLTSLSLTHVQFHPQDLLGELLAYITLAPLAILVFYASVIVARREVSGILFLAGQLSCEALNALLKEYLQVSRPNDHLGTGYGMPSSHSQFMAFFALQVVLYTHFNIRLDHPHIKWLLYLPTLALAALVMYSRVHLGYHSIEQVLVGCGIGMMYSVIWFSFAEYVRQLGLINWIINLPLCQSIYLRDSRSIDNVAKWEYEAWKENALGAKKKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZW8</accession>
    <name>A0A8H7PZW8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZW8"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2183522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="110" mass="12321" checksum="089ABB823A223DD1" modified="2022-01-19" version="1">MPAICNLLIVEIIMAPSVEGFFRYYSLFRVQLSTGMVYVKIDISEQHCQVQDIVDFCANAAITIVDIKDNLVTLKTPQTPVLVKVMLNLYLIDLHLEGSLTDEGFEDVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q187</accession>
    <name>A0A8H7Q187_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q187"/>
    <dbReference type="OrthoDB" id="10293743at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="219" mass="25100" checksum="2925EA66BFDADECE" modified="2022-01-19" version="1">MPIELNIAMITYLSVGVNEVKEFNDDVKNETKETTVVMLEDHLEPYLYNLWRQTDAEFDNEGFNPRTHQWQGSNATSHVTPYIYTRRCIFSNYYLFPSSTFFISMVAPIPHFVRNWFYGTMLLAGCQYWGMGNKTTPYLLSLNLGVLICLMAIHVFKPDMMPDALRDAVAAPVPVPAAAGQTKNDNRKKKICHIRATVGNGGIVWVMFASYWARQSQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1F3</accession>
    <name>A0A8H7Q1F3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_006561</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1F3"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="44"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2183555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="273" mass="31162" checksum="DF75B95BEE307D6E" modified="2022-01-19" version="1">MATFSRTTFNSSLYRSFRPVYSKTTYDLIYEYHKQKGGKFNVALDIGTGTGQVATVLAETFAKVHATDLSEKMLQAADKRPNISYSACPAEKLPFEDKSVDVITTAQAFHWFKHDQFFEEAKRVLKPNGTIAIIGYEYARIRESKQASSLIRKIGLETFGDYWDSGRKILENLYRDIPIPYPNTTYYFSPGDADITNIGNPTPETIMEKVMTLEAFKNYMHTWSSYANYMKEHSEDPVDSMMNEIAKLLNADNLEKHLVTVEWPAVLILTTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2A4</accession>
    <name>A0A8H7Q2A4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_000517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2A4"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2184608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="134" mass="15535" checksum="5BB529B6C50CE6F8" modified="2022-01-19" version="1">MDIEDLRRRFELACELYRIPARMFTHGLQQLETIFDLPATTNRNLFMRPQTGCHIIVRPYSCFRMVYLLFKGEGLAYNERNNSIIIPSTAEVYAGQTMNFHTENPLAGEECETQMLYCVWATTSPCIKGTAWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q392</accession>
    <name>A0A8H7Q392_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavoprotein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_000648</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q392"/>
    <dbReference type="OrthoDB" id="1532798at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="3">
        <location>
            <begin position="9"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2184735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="132" mass="14487" checksum="B214B6FA55B6EFBC" modified="2022-01-19" version="1" fragment="single">AWTQIKDPVLHIELRNWADIMIIAPLDANTLAKAANGLCDNLLTCVLRAWDPARPVLACPAMNTNMWMHPFTEKHLEVLESLLSYKIISPISKLLACGDLGVGAMAEVETIVEEIDQSLHGSPAKLTDSDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q488</accession>
    <name>A0A8H7Q488_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q488"/>
    <dbReference type="OrthoDB" id="5554140at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF1">
        <property type="entry name" value="RECYCLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2185025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="883" mass="99946" checksum="AAF3F82D02AAF988" modified="2022-01-19" version="1">MADVSFLSDESAACSIPAIAPQMLSAARFLQPDILIHIFKYLPIAATRNVALCSRRFKVLVYDDEIWDEKLRCLGIETPVTVTTQADNAKAADTATLSLMGSGSSLYINNKPLNELIPGLKLDPFTARSRARSTGKAREIFSQFYTRLYPFYVSLRNTTGESMVLSEYGSEPEECGKILNKLVGLGKCKAVDDYAQLNSETEKICRYFESACLHEFELAYDTQDVDRMQASIEQQYAHALVELNGGQSCIQTFIQKHSMFYDNPFTPDANFRSTPPNFQPFKDFMEAIGDELKVQSNLIHEVFPPKADVYYIFADRVFEDVIAEYLETVLEKARSIDLQLYLKIVASCLDSCLGFVEILTDDKQPSYLEKERTMNILFKLFLPLMDDYLHDEQEYISQACEKHINQWKATASGGHVNTANTISNQTRESFKRKYLSAFKKIVSVPVELVSSAATTISSPFQTKVVPSPDISVDTSAANTPTAGPSTPEIGQDEEKDKNRLSAPPASVVVEDTDKKSAENGRQLSSSQTGSRPNSVSSVKSENELNNAMQELDALQHLLSLELCLQLIHINKDAEHRVQRFVKVGFPGRLRTDVQKCAEHVFTTLLKKLGPKHIKTGFDRATLHLAKYTPQEDVESADQNNVAPLTEFFELVHIADLIQQMIEVYWKEEMLKVVDRHDFLNEVNKEKKTFERLLDDCVAQGMDQGIQVLIAQVEYILVTEQKGVDFHPSPDSLADLKPSKACRDAIECLRTHTEMLRGSVEKETMNIFYQEVGRRFYELLCKHIKRQTINEQGGFQIISDLNAYDNYIVSLRQRTVTPYFAALKALANIYIISNPSDIKDVIHDLERYHGMLRIEDLFEFAACRSDWPNIKKTVQKDMTDCNIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5B9</accession>
    <name>A0A8H7Q5B9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_000894</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5B9"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00503">
        <property type="entry name" value="Frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00904">
        <property type="entry name" value="FRATAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2184981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="186" mass="20901" checksum="F9D33889833E5A3D" modified="2022-01-19" version="1">MNNIRFATRACRLASRALPRAQYTTVARASSHLGAKVLRSQSGILSLQFNKSVLPTTSFSQKLYTTQTFTAAQLTPGEYHKASDLTLESILDVLETIGDEHDIDGYDVEYSQGVLTLKLGSKGTYVLNKQPPNQQIWLSSPKSGPKRYDYDADHIKWFYARDNHTIDELLNEELTEALGFDVKLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5M0</accession>
    <name>A0A8H7Q5M0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_002756</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5M0"/>
    <dbReference type="OrthoDB" id="10258210at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003121">
        <property type="entry name" value="PRK04038.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2186318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="18085" checksum="BBAB5373ED270723" modified="2022-01-19" version="1">MNDRRTSFFIVMADQDQPQKRRTFRKFSYRGVDLDQLLDLSSEQFMELVHCRARRRFQRGLKRKPMGLIKKLRAAKKEAVAGEKPAVVKTHLRDMIVVPEMIGSVVAIYNGKVFNQVEIKPEMVGHYLAEFSISYKPVKHGRPGIGATHSSRFVPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5N0</accession>
    <name>A0A8H7Q5N0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_002860</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5N0"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="407"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2186422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="437" mass="47918" checksum="252629FDBE02EFD2" modified="2022-01-19" version="1">MTNSSSNFDYFEELSSPQNMNPYLSAVVIPTPGSPADNDLFANLSPDTAHSQQQWISHQQQQRPSSPRPVNIASPFISPVDVSPLLSPASFCSDHFPGSGGSSPEDAHAWRNSVDALLAMNTPVTVPSTTPPLLGSSYSSTSSALLSMDTPPTNADINPLIEASPFINPSPIEQEDQMSAFHPGRSDSPYTARTASISPTLSYVEDNSVESLFHRFNLLENQLDSGSRSRSESALPNFDFDPIPMSTGQNHLGLPMLHIPRRSSFPNMSELVSPEITVTPAAADDLHFAGPNSALTPPLPGNTAFFDADPQPRAIANSNRPYQRHQRSHSANSLQAILGSNVPVPVATTSSGSSSGSRVRNQRQVVRRSASNSSRPFVCRHCDFAFTREWNRKTHERLHDRSFVPEHECTYCDKRFMRKHDCLRHMNSVHKAQMTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5N7</accession>
    <name>A0A8H7Q5N7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_002875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5N7"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="135"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="656"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="299"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2186437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="761" mass="86191" checksum="BA9CF5BCFE0E05D3" modified="2022-01-19" version="1">MGKFHLPVSPAPTTSSKNQSIPVRQKEPLHFRAASNRIAKKAGNFLSKSHTTVISSDRNSLRSFLPDQPAVKNSPLRRAFSFKDSTQKNKTPNRPLLLDQSQMQRIDVAVSTSTWRQQFREEELNYLALDSEEVQYQEAIYEIIATEADYVNDLKLVYKIFIKEALEWEGLPKPVRLIFSNIYQIIKVHQNLLDELQKRQTAQYPVVKSITDKLRQAIPMFHIYAAYFINFEKAIEIIKQASDSRSDIFGTYLRERNALPDCRNLPLHAFLLKPVQRITKYPLFFKSLLESTKVKAFEHQDLRQLLQEMESAIAKMQEEQAKNEEYQKLEDLEQRIAGFEKIPSFKLAQFGRQLILEGFLTVVNDPNGGTNSPSGSGAFAYSPSVESFNSTNSFYSSKDFQDQNTSRPMLKRRDSAFGSSGSKEIYAFLFNDLLLWTKVKSKPARGANVELHNHTTEPSKAFYGPHAGARLKLCSLPAKVTHIVENVPIFRRPETNVFYMNRNASKSGYLGGSMKSPAVQNQHPFSASYHSLHLDIGSSQHVIEFQPLQFACSVAHRNSETLTFQAISEQAKLEWCSSLNNVLGSHVHRINETDDWWKERQQKKDAAIFNEATLMAPPSYRRTFGDKGVEVQDIVGIVGMLSPSGDSMIPIADVLRNDKDNKSPTSLSDSSKDSSDDSSFMELDADTDMDAAIPPSSFEDYVEPSTAPLEASPFMPRSRAQKQWQNRASKLAMGIQDIRGEVPGKVIRMKFGQPSRQRPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6C5</accession>
    <name>A0A8H7Q6C5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6C5"/>
    <dbReference type="OrthoDB" id="2120024at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2186088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="89" mass="10534" checksum="9CFA9C87BA87634C" modified="2022-01-19" version="1">MLGRSLYKVTSPRLYSASGQRFYATSRKPSFWYSYGTPLFNLLLWSSTTTLAFHLLWHKLDYAEFKKAREDEIKDLEHRIKAIQDSKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6H3</accession>
    <name>A0A8H7Q6H3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6H3"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF3">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="627"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2185974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="73319" checksum="CC8ED47B80BEFD39" modified="2022-01-19" version="1">MADIVASEHPTDPHMLPTMGSVDHPSSLNNQADQSDPARQLSLDRLTLESNQPSPQSARNPSPSFADKPTAYTDSPYVQKPDVVDSPSSSSLDGRPPSSSAASSESTPEPIKPALPVPGAGPPPGHLQAYNPHQPPYRGHSPYSMHADLQRGNTYRPSPVMAPAPRPMYNGEGMNGHPYQTPQMAPQGLAPQQPQMYWDEYSQQYVPQPYNGYNQQDYYRQQQMYQDPYAQAPYDEYMMQQQQQQQQQMQQQQMQQPINNEVLPPIGKRPGKKSEFPPPTLDNLSRFRSEARGTNDPMVQLKFAKFLVEAIPQVCTEDPDQKRARKIREGMANEAQRIVKKLAASSSIGKTTHSEAQFFLGNCYGSGTMGLSVDHDKAFNCYVQASKQSHPAATYRTAVCYEVGAGTKRDHARSILFYRKAANLGDTPAMYKLGMILLKGFLSQQKNPREGISWLKRAAANADEENPHALHELGLAYEKEGIPSVIADEKYARELFTQAAQYGYAPSQFKLGCCYEYGQLTCPVDPRRSIAWYSRAAEQGDVEAELALSGWYLTGSEGVLKQSDTEAYLWARKAADKGYAKAEYAVGYYTETGIGLKPEFDEARRWYMRSAAQGNKRAMQRLTELKKYGNARPQQRQKHTRAANGAPRKQDSDCSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U6P5</accession>
    <name>A0A8H7U6P5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_008242</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U6P5"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="9">
        <location>
            <begin position="56"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase jelly roll" evidence="10">
        <location>
            <begin position="753"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2171516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1057" mass="119719" checksum="7C15524B7785ECD0" modified="2022-01-19" version="1">MASPLLSLLAIIPATISALFVYWHRRTYGSLNIHTTDVAYHRQTYGHLLDWDKYTLSIEGNPTMIFSGEFHYWRLPDRNRWESMLKNYKSAGLNTIRIYFHWGYHSPAQNVYHFDGNRDIDYLLTLCEELGIYVLAAPGPYICAETNGGGYPAWLVAKRHLRIRHNMVMLWRLYDAEFAMHEVDWYNQILPIIARHQVTSNGNKGASDKGCVLGVQIDNELFEVMHGLLPVGLHDQMKILARSARDAGITVPLFTNDGFEEGGWIPRTTFARTGMPHRDQKRGFGIDWYGFDKYVVFAPSSSPKSWLIDNDQGTDEWSDWDPRTVKNSVDKIEKTVRGFGGGAAETPLFIPELQGGWFNHYLLNHTYDEIYNFFGENYTKLIVDSMLAQGVTMNSVYMFYGGTNWGMVGDPDVYTSYDYSACIREYGYMSSRLRALRQTMLFARSFGIYFAKTDRVNEPKVKVSIDDVFNTQRATAADQADQQVEFSFLRNFDKKKRDTFEVQVQHTTDDNQIVNVSLSCQLPYKQTMTAVGNYVAANGARLILSTLPILTRIVKDAETEVWVVAGNSIGEMAFDNSDNDLEFSGNMHHAVRQQSTAAIVGFGDVQGWTKVTKNGRNLFIVSLAPADVSTIYADFYDPYWSNTQPTSQPVVVTWGSDSAYYDRNEQQLQVHFNDLDKDLHIIAFDSPVGQKLALDNEKYNLPFIYKKDLTKGLVKKDDLQISLSNWGTRRTDLAGLSWSSLVPQGKDKPTFNAIDHLYTSGHILYRTTFKASANNTVTLSVNARNRATIILNGKIVGGHTTYSRQLFMPGAKIGPDPYFIGSQKYKLPNELMNENGINELVITVDSFGLCRQAFIMNDIRNPRGIISAKLSGLDGQAKKEADQGWQINGVDVTQLSNQYDTTGWPDERLKTSHWDPLAVVEEVKNHPVTTFQVLTADGPKWIRFTFDFDVLKRNPDMQFPLRLHLDGAFTAIIILNDVVVGRYYGNGDGPQHDFYLMDGLIHPLDNQIEMLVYSWEDVNEAQVSISGWPVQPGSGNLAKPYGKHEAEWKTYATSVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U6X7</accession>
    <name>A0A8H7U6X7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U6X7"/>
    <dbReference type="OrthoDB" id="2257025at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="139" mass="15573" checksum="AEC4CD62FB1FEA83" modified="2022-01-19" version="1">MTIHAASILHRKADFLKPSYGGCIDDAESGYHRAIDILEDDVQDVNTRKRTLDYLKEGMTLLRACKRQFVSNRTASPTPLSTTSFARKSRSPPPANSLPESSSHLQTIPSEQPPSIYDSVATSESCKNWRYHEAYMAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U751</accession>
    <name>A0A8H7U751_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_004509</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U751"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14500">
        <property type="entry name" value="PTP-IVa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000086">
        <property type="entry name" value="Protein tyrosine phosphatase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="10">
        <location>
            <begin position="85"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2173136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="177" mass="19990" checksum="353F5BBCCD7C3EEE" modified="2022-01-19" version="1">MVSSNTLINPPTLIDTTPDIRYLIVDSPSQSTLPLYIQVFERWNVTQVIRCCEPTYPKQALEDRGIQVHDWTYADGDHPPGHLVSDWLRLIRQIRLEAKEKQQAGSENIIPCIATHCVAGLGRAPVLVAIALIEDGMSPLDSVELIRQRRRGAINTKQLQYLESYKRQQEAGACRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7D4</accession>
    <name>A0A8H7U7D4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_002912</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7D4"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="392"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="681"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="726"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="692"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="728"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="781"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2171290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="851" mass="93316" checksum="D7A374C8F65CD73C" modified="2022-01-19" version="1">MEDIQTSLNNAKQLTEDGNIKEGYASNLALMETLMKQMHDVKFVHHSIVSKPANYNAMLTAMRACLSNVEDIVNKHSPSAISSTPPASRRNSLLTAGGSTRSRVGSPVSVSIQSATPTNEEEDPITSSKSNEKPGKPAPPLPPKPSRMHNKPAVPPKPARSSTSSRPTSPVVTPNHTGSTITSQSAQSSLMDNATAVIAEDAPVAKTEPISRPKTEQTRPRIPPTSPQVPARSRPQTMPDPSYLKPSMAQRPTSIATSVDTLNDSALLRVVAEGEIDPTNLAPAQTNSGDSLAPSYKHTSDHVPKIPAPPLLTTYRLIQAKHDKLDSELKLLKDKKRHLLAGGKDENGASESDINSAIMSYTALTADAKLTLNKVRTIYMSAATIPSVLQFQPHLVAYQITLIEAAIFIEIPVDCLLVHSARTPHPRIVASTDFFNYTTRMIEHSILLPQEASHRAQHINHWIKVAAKCQDLNNYQTLKAIVSALGTPPVQRLKRTWACIPRKSMLKLEALNELMSERDNYGRYREHMGMVNTGMINGRSVAQIKAEHAARPTVPFLGTFIQDITYLLAAVKSQNLRKPTDDPRIQEVLAVMEKFQRGPRYPHVPSASYVKASTTTKSSFRPTSLTNALHRSSSKKDRLSAASLFSGVEDEDEEIRDLEEQQQLVTQYILMRPWVNEETVDELSSLREPPTSRVASSPSSRSSGGAGSGNYNSSIMSNTSSSFVRLSAGNNSGSDSRPTSMDDFGEDARSSMASEDADSLKRGFWPFRRSHEGRRPGSIITDRTSMSSFPKSASEINVSRTDDTNSDDEDDDGRSGHFGWTKEPSPVIRPPDNFKQNLAQRLAGEFERRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8R8</accession>
    <name>A0A8H7U8R8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8R8"/>
    <dbReference type="OrthoDB" id="341898at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="407" mass="47319" checksum="B9943BDC3E84578F" modified="2022-01-19" version="1">MEQSSVRAQLEQLRLEHARSRRNAYRNQPHSTQTPEIHPFLNYESGAPIPDIRTRSRPGSYRRIPGPAPPRSWITTNRAKVTAAHEQLVISERIRKRQKARRELRSLCDTCAYNLGYQTLFNQDYAWHIRKAVKNLPIHLKEEVLYAISEIGGMNDRLLPYFALTEVSELCLANCTLSAELFYKEFWKVETRRHKQVKEVKDTWEDIDDDESDSMEILSPPLDQFEERQFVNLYLVARSINPSIDLSKRWIITTKLTQLTTLDISFFRPHLPALATSELIVTTLPHLISLSTAGTFQRDNGSAALSVLSKGLRKLQFWDIGYHEWITPEVICGNASMVLINWDRDLQNLDFLSLENIGPGNSSENEAAKEVKRQFYEDVQVFKRAKRRPIVLMHPQQYRIYNQYSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U960</accession>
    <name>A0A8H7U960_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_007585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U960"/>
    <dbReference type="OrthoDB" id="10462098at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2176931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="38638" checksum="F3D9401BF30F7F71" modified="2022-01-19" version="1">MDTISVEFDSRKVDGDFVEPTSVEMKALLRKIDIRIIPLMTYMYLCTFLGRFDVDHKMYRPNSYIENFISLSLPYIAYPMVEVPSNLILKKIGPSKWYPVMLIIRALVIFRLATASCLAESLILRFILTSAEASLFSGLIFSMNIWYPKIKKAQNIRLTYIVFCYFASIFFTTAVTYASLQLDELHRWSGWRWITIIASNSTLPLVILSYLALPDFPENFKFLNEREHSIICRLHVDANDLEQPTLTWKPLRLATPDFQVYLSSTLYIFYRNLMGNIIYDMTMSSTITNVIAGITFVQIDGWWAYTPTIAAFQNLGRHFYSVPDAVFIIRLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9D7</accession>
    <name>A0A8H7U9D7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9D7"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="272" mass="29505" checksum="F1868BD45B839891" modified="2022-01-19" version="1">MNDPDNWSDNMDDYLTFAHNGTLVFAKGALDFSGVEAKNGNKILDVACGTGSMVQAIIEKFGPQCDAQVLATDFAKGMVDAVEKRAKADGWINVKGQVQNAMDMTLPDSSFDAVFCVFCVMLIPDPAKALSEMLRVAVPGGTVTCVTWNAQGLLPMMQKAASLTKNLPAPVPFAFKGWADLDFNKEQLQAAGFREVRGVHVPGLLPLARKDIPEFVDSLPRNPGMKAGMFSSFTEEEINTFKGHMRNVILESFGDKEHYGFEAVANVVCGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9I3</accession>
    <name>A0A8H7U9I3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007993</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9I3"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080042">
        <property type="term" value="F:ADP-glucose pyrophosphohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080041">
        <property type="term" value="F:ADP-ribose pyrophosphohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03424">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5_UGPPase_Nudt14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF18">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="111"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2177336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="276" mass="30551" checksum="93662AC7DCCD3D43" modified="2022-01-19" version="1">MFLQPFARWSNKQFIRTISKMSYNISIAGKSIPVQPASSDLDIKPVFEFQPFKDWCSTFEKELSHSKDIKINSIQVQNVDYFKGGKPGFVKFKADVELTESGKKVPGIVFMRGGAVSVLIVLRASDDKEKGDRVLFALQPRIPVPSAQLPELPAGMLDGSGNFSGTAAQEIEEETGLKIKDDELVDMTELAYGDKWRGVYPSAGGSDEFLRLFYCAKSMPTKEIDELEGKLTGLREHGEAITLKVVKLEDAWKLSPDAKLLSSLALLDALKRTGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9U4</accession>
    <name>A0A8H7U9U4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_006072</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EMC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2175010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9U4"/>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="82"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="EMC2 TPR-like" evidence="5">
        <location>
            <begin position="84"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2175010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="259" mass="29902" checksum="2F5D9221330220A5" modified="2022-01-19" version="1" fragment="single">MARFDFDTSREELQTYRSSGERASERVAYLGSRIIKDGYYKKLQDDIWPFYEQVATAALDVGDFRLANDCIDHLQKRFTNSTRVQRLVGMRYEAEGKLNEAQKVYDTILQEDESNVLVSKRQIALLKLRGKKHEAISALVKYLDTYYSDAEAWIELSQLYLSMHLYQRAAFCMEELILLQAANPIWHLKYAEITYTMGDVSLALKQYCRVIDLSTDHLRGMYGVHLCSSKLISQGNTDQKVKALKELATERILAKEADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UA13</accession>
    <name>A0A8H7UA13_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_003123</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UA13"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140824">
        <property type="term" value="F:thioredoxin-dependent peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000010">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="9"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2177876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="172" mass="19549" checksum="8A59E9D3A76490BD" modified="2022-01-19" version="1">MLFFHGNAADTPKSFYDFKVKNLKGQDWDLNQEAGKVTLIVNVASKCGFTPQYKGLEALYQKYKDQGFTIIGCPCNQFGYQEPGNSDDIQSFCSRTYEVSFPLTEKLNVNGAQESPIYSYLKESQPGIFGIQMIKWNFEKFLVDKNGKVVRRYSSMTKPEDIGADVEEFLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UA16</accession>
    <name>A0A8H7UA16_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Integral membrane protein S linking to the trans Golgi network-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_001491</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UA16"/>
    <dbReference type="OrthoDB" id="542931at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="215"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="230"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2172014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="31403" checksum="D8316F352466703E" modified="2022-01-19" version="1">MPPSSFRITTWDPILLIAQIISLQALYYVSISILILLVLAITGTELSLDYVLDYKEIRADNVMGWTISFCWVLNALVATALMVLIVQRAKLILDFAVTLHVFHLLFTSYYSRHIPSTFLWWTLNIFSCVVMTFTAEWACMKREMEPIMVNARSDPDETNNADSGRKRKTSDHGVVSSVVDKGKLMLENATGKGKGKYENISMDEMGDVVVGTSGATSAAAGSRGEGTDGDDTRGDDTRGDDTRGDDTRGDDTRGDDTRGDDTRDDDTRESTGSGAATMDDTLVLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAD7</accession>
    <name>A0A8H7UAD7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_004300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAD7"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000064">
        <property type="entry name" value="GNAT family acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="371"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="431"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2174277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="576" mass="64373" checksum="00A59ED5E9B81207" modified="2022-01-19" version="1">MTTPDSTAKAHALVYQFLELNGYTETAATFVKEANAVANIESYVLKSTPQVPLSQMVQEHELNTVTTQIKNTDLHRAHWEKDLVEGDGSHPTILESTIKDVHEGNILSVAIHTLGSMKMIATGSGDKSVKFVDASTGEVVKTVKNHKAGVLSIDFHPIKPNLMVTTSMDTTSIITDIDTDTIVQTFSDHGKFVVRGIFSPDGLWYASASYDRTLNIYSWNNEHGYQLVKKFGPLVGNVEAICFLPDSLTLVAGVRDDNYLHYISLKDYSDTRYNMNSNGDDWVSFTPMWLSVSPNGKYLLVSTDDSNGRVILFGINSAVQLRNFYGAATDMLSSAPRHCWDSSGRYVYIAGGNDCRIRVIEVKTGKVAYQLAGHTAMIRSLAFDETVGLASTGFDRTVRLWRSEDTTMRFSIRSAQSSDAGLILSFIKALAEYEKLSHEVTATEEDLRKNLFENRYAEVVIGYHKESEESEEANESKVPAGFALFFHNFSTFVGKPGIYLEDLYVHKEYRGLGYGKKLLTHLATVAKERECGRYEWVVLDWNEPSIKFYQSLGAKPQKQWIIQRVDGKALDDLANM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAE9</accession>
    <name>A0A8H7UAE9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAE9"/>
    <dbReference type="OrthoDB" id="2336986at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2172449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="125" mass="14048" checksum="C591366AD3E88761" modified="2022-01-19" version="1">MDLNQRTNTNVKPAGFESLAIPLLKQYNYYFTHPAHLHAQVQPLNVEELSMAQSEIPPRKALALQRHSSAGLKQTEPATNKGLKLSQLDDVIEEKMVRISRTLLATTVLLRKNKAKAGIKKNYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UC58</accession>
    <name>A0A8H7UC58_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Threonine/serine exporter-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_005385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UC58"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="515"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="3">
        <location>
            <begin position="183"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2176152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="585" mass="63779" checksum="638B699842855420" modified="2022-01-19" version="1">MKTVDDDLRNKKLNRLSQISIELAAEAEASSIQIPTRASTIAHSPSRHCSGLQDLEKSENYLCYDKEEDDCSEESERTHSSPVQKLLRLVDFKSSIHLSNILRDLTREEANIQRQSVSSVWSAGELTADQKLNGIYSSQNINLQFSDAVSTCCSSDGSQTLVNNYNNETDRQLAHSNGRKKLYLIRLCKAMVRYGAPSHRIESSLQKSADSLNIPTTAIFLPGLTIICFSDTKQHTIETLMIKCDEGFDMGKLAQVYDIANATQQSTIDVKTALQQLHEIKLSPPTWGVWAKLFAYTVSSFVAAPTMFGGSWMDSLVSGFLGLVVGILVILADKYSTFSNVIAVATCILIGFIVRALSPYICFTGVVLSAIVILLPGYSLTVSIMELSSQHMITGTVRFGYSLLYSLFIGYGLEIGSSFYTAIDPGIPSDFATCNNPVSPWVYIPLFPIVAITTGMTFGAQIRQWPSVIICSCLAMTVAYFAGKVIMESQVVATIGAFSIGIFGNIYYRLTGELTLVPLCAGMVLLTTGNIGVKGAFLLIQENDDGGTFAMEMVLGSLGIAVGLFAAALLPTFPKHKRRSINLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UC75</accession>
    <name>A0A8H7UC75_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UC75"/>
    <dbReference type="OrthoDB" id="4023585at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="164" mass="17361" checksum="9ACC3F859E168EE0" modified="2022-01-19" version="1">MSFIARTQANSTIYKAICQQQSRRFTVIAAQRKSPIDKTKEVAQEANLKAGQGADKVLEKAEQGVNKAKSVKGAYEEKGVKGATEKVGHDANIAAGEGLAKGIEVAETLVQKTKEAVGLGKKKADNVAGEVQKEASHISEKAQGKAEEVAGKARQTASDVKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCZ3</accession>
    <name>A0A8H7UCZ3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Stress response RCI peptide</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008623</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCZ3"/>
    <dbReference type="OrthoDB" id="2427407at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF40">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034127277" description="Stress response RCI peptide" evidence="7">
        <location>
            <begin position="21"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2181041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13585" checksum="24BBA2C4A2BF15A8" modified="2022-01-19" version="1">MIAVILEILIALLFPPAAVAMITGCGADVCINRLYPKLGYLPGHVHAFWIIWRKYDAEERSGYYRGNHGHNYGSLEQQPPAQPQQNYQPPQSYQAPPPPPPPPPPQQAQPGFDSKPPAYQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UD07</accession>
    <name>A0A8H7UD07_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3020 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UD07"/>
    <dbReference type="OrthoDB" id="5595797at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021386">
        <property type="entry name" value="SPP41_DUF3020"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11223">
        <property type="entry name" value="DUF3020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3020" evidence="2">
        <location>
            <begin position="126"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2181086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="352" mass="38216" checksum="06716F5AF881BBCC" modified="2022-01-19" version="1">MLAKQEDQELTTPEQAAGQYVADLSEITAENKQAPTETSSVSMPTSNVALDLQQDYQAQFSAAQAQAVAQVAAAMSQANNGAYPVEFASAVPGNPDVQSHVTAVQQPNSNELYRKTLISDKVRAENRERKKRWREQNEDRNKDNDLRCRVNKRANRLFGAADSEHKRSWIEREFVKRQSKRKEKELRKTSIGGSPNPTGSLGNDHMQNAGQSGDLSQLQNSAYYSMGNNMAPLSPNTAAKLLNTNLAEAMKAQQESSQLTSAQLLEKLLQQAPAPQLEGSQMQQFNGQSGEENSNSAQLTDVTSAVSQSSTATVTAPQTTTAPNGGAAAGQNGDYPMEAVLTLMQLNAGWRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDM7</accession>
    <name>A0A8H7UDM7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">hydroxyacid-oxoacid transhydrogenase</fullName>
            <ecNumber evidence="4">1.1.99.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_001955</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate</text>
            <dbReference type="Rhea" id="RHEA:23048"/>
            <dbReference type="ChEBI" id="CHEBI:11047"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:24734"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16724"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.24" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDM7"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047988">
        <property type="term" value="F:hydroxyacid-oxoacid transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08190">
        <property type="entry name" value="HOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000009">
        <property type="entry name" value="Fe-containing alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000003">
        <property type="entry name" value="Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042157">
        <property type="entry name" value="HOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="9">
        <location>
            <begin position="73"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="10">
        <location>
            <begin position="295"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2179105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="489" mass="53016" checksum="009AD9DAB3706243" modified="2022-01-19" version="1">MPNVPSRATVSRLMTLLQSSAKACPCHSHAHSHHHHPSVTTASFNNLLRYGRQYASAQDPSQQKEYAFEMAASNIRFGEGVTSEIGQDLNNLKAKKVMVLTDPKIAKLHPLKAVVESLERNKVNFVVYEDVRVEPTDVSFKQAIDFAKKHNPDAFVAVGGGSVIDTTKAANLYSAYPEADFLDFVNAPIGKGRPVDKPLKPLIAVPTTAGTGSETTGTAIFDYVPLHFKTGIAHRALKPLLGIVDPLNTRSMPTQVHTASGLDVLCHALESYTALPYHERTPRPSNPLQRPAYQGSNPISDVWSLHALRMVVEYLPRAVKNPDDHEAQRNMLLAATFAGIGFGNAGVHLCHGLSYPISGLNKSYKHPEYDVDYPIVPHGISVALTAPSVFRFTGELCPDRHIDAAVAFGADRATIKQSTAGHVLSEHLTRFLEDLNVPNGLSALGFSSSDIGELVKGTLPQERVTKLAPGGAPGEEELATIFEASMKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UE95</accession>
    <name>A0A8H7UE95_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UE95"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052907">
        <property type="entry name" value="Beta-lactamase/esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319:SF3">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="73"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2179750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="468" mass="52867" checksum="5A135CB4B9E08C71" modified="2022-01-19" version="1" fragment="single">FSSAISTTYSFLPTSMARAGVYLLPIIAWLIFKILDKNDFTPYPCTLLNLKCPMPIASGFVVPDYAKLKSLFEDNFAKGDDVGATVAVYVDGELKVNLAGGYSDRESGKPYTTDTLQKVFSCTKVMTSIIVARLVAQGRLSYSEKVSTYWPEFAQGNKHDVTIKDLMEHSGGVSWIDEPVSIDHFKDMDSFAEFLAKQPHNFNGNKTRAYHAHTRGWYLNEIVRRVDPQHRTIGQIVSQEINEPYGVEWYYNPESSLDDRISKPYHTSFFRLIKRWSTPKWLYTVAEPLPEVFTMINDKTTPMYKSLITTGADKRDIIRQQELIVRRYESPSTNGHTNARSVGCNFLHIIAKIASIMANRGQPTAADEPALLPEQTYELATTVDLFEFDVVLRQSVPLTIGGFGQFEVANTTFTGWVGAGGSGFWWNEELKIGFGYCMNSFRWTLGLDRRALKLIETVIEVVKKEKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFF3</accession>
    <name>A0A8H7UFF3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phospholipase</fullName>
            <ecNumber evidence="9">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_006782</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="9"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFF3"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01254">
        <property type="entry name" value="PH_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="84"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="845"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="752"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="792"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2183771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1084" mass="124667" checksum="E083DE954C3D4B96" modified="2022-01-19" version="1">MCQLVLHYVANRARANWGKSLGKVKLVNNLNSFSKQTKNHLVAPSYPLVPFYPPAFSVPYIAMSRDEYERKPVCKMIYPPILFDVLSLAITDSSIDQHALNKQWVFRIELGYGDIKWVIKRTVVDFYSLHLTLKFKAGLSTRTPHPPPFPGQLAHLYHALTSMPGRTIEEEKDDNRKDSNLKRREQLEEYLKDLIKKSHMVVNYDLCEFLEISAISITRDMGWKGKEGYLENRLESVLPSLCQAVNFTKWNKEWVILRDSYMAFCKDIGSTSPTDVLLFDRHFKANASSHFLTPYNQHHITIQNGSRKIDIKGPATRVIEDWMASIKRVQNESPWVKHHRYDSFAPIRSNAKAKWFVDGHDYYEAIAEAILAAKSEIYIADWWLYLKRPPEDNEHYRLDRLLEFKAKQGVMIYIVIYKEIEMAVALNSGHTKNWLQGRHPNIFVQRHPDHNATARQRVFFWAHHEKMLIVDYRLAFIGGLDLCFGRYDTHSHRLADYPAKGHDKEIFPGQDYSNPRVKDFANVAQYNLCLIDKKVIPRMPWHDVALGMVGPPARDVARHFVQRWNHVKSTKGHKRTNLPFLTPKGEFVSARDETKFNGTCRVQIVRSSAEWSQGITREYSICSAYMEVINKAKHFVYIENQFFVSATHEGDKLIKNKIGQVIVERIKRAHKEAKAFRVYVVMPLAPSFEGEITSSDASVLRLVMHHQYRSISRGGNSILEKLRAVGINPEDYISFYSLRTWDKIKSDHVYQNKTKAKAHNGSADENSDRANSSTDAVEGRANGRPQVPLRQNSKKGRQHKKTRSVTSVGTRKSEDTFGEEMVRSATLSSTNSMELNDGRMDYVTSMVYIHSKLLIADDRIVVCGSANLNDRSQLGNRDSEIAMVIEDTDMVDSKMNGKEYKAGRFAYTLRTHLFKEHIGLLTAHERSTLNDMRTNLPYGHSKRTSMADSTGVLNIPCASPQTHDDKTSNDIADSIVMDPLDDDFYYNYWHRIASRNTQIYRSLFRCVPDDTVTTFEQHKRFVPDPTIIPEGHIAHPYRMSVDEIEDTLSDIQGKLVHFPTKYLREENLQGGQVKGAVTPMHLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFR2</accession>
    <name>A0A8H7UFR2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_008953</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFR2"/>
    <dbReference type="OrthoDB" id="274622at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2181370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16684" checksum="B508B046D3FDBAC1" modified="2022-01-19" version="1">MSQNVGKTALAYARVWHLVDAKQRTLGRMATGIATTLMGKHKPIYDPAADCGDHVVVINAKEVAVTGKKWDQKLYRHHTGHPGGLKEIPMSRIMERDPSKVIHKAVSGMLPKNRLREPRMERLHIFEGADHPYADNIIKRYDEGPQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UG92</accession>
    <name>A0A8H7UG92_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-4-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.68</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-phosphatidylinositol 4-phosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphosphoinositide kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PIP5K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_003372</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UG92"/>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17303">
        <property type="entry name" value="PIPKc_PIP5K_yeast_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase its3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="13">
        <location>
            <begin position="218"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2178119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="638" mass="72374" checksum="EC4D4AB186DB3EFB" modified="2022-01-19" version="1" fragment="single">MSSDQHLSTPAMHGKEIGQANGNAVEDLGKVEAISTLSQDTSPRTPLHVNLHPDGLLVQEPMVASPVSIHPHDAIASKLPSSPLGMKKSFTGPPTSTANGRQSDTLYQRSATTTLIPQLQKQQHLAAQADQVSATNGYPNLLQRTESTGGIPNPSRFSGDRLERRSTVGPDLGELAPDEQLILEQEIAARRAARRASRRRQETEDEDRVMIGTRVAEGHRNYQLMYDMLTGIRIAVGRVSAKMKRDLTTEDFKAAHKLVFDITGNELTPGVKYDFKFKDYAPWVFRNLRESFKIDPADYMISLTDKYILSELGSPGKSGSFFYYSRDYRFIIKTIHSTEHKFMRKVLRQYYDHVVANPNTLLCRFYGLHRIKLPHGSKIHFVVMGNVFPANRDVHFTYDLKGSTFGRVTPDEEVQKNPNAVMKDLNWEQRNCKLQFGPEKSNILMQQLDSDVQVKFCRDHCYTSSSETDDLGNQLLIKLNIMDYSLLIGIHDLKRGNRDNIRDNHLQLFQPYTKRVERQLSLRNKRESKAQIVRKAIATADPTKLDVSKLPGNPSTERKYCVFYADDGGFQATSEDDEPSDILYFVGVIDILTPYNYVKKIEHFWKGMTLDKKAISAVPPADYGARFLRFMHHSLKHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGA0</accession>
    <name>A0A8H7UGA0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGA0"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="162"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2181955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="386" mass="43309" checksum="C1A461BC952DD2C3" modified="2022-01-19" version="1">MGNSHSTDTPRHSSLPNIPVIERSSPALKFPRSITSQNSSSLSLSGNSKFSSAGKLSLDSLPVSSIHPLQNGSSLLAPSIKSPGSSRRNSFSSFRVTTSPEPEKYVWIAGKRFHNVEGSGYLFPCDDEEIDRMHLQHFMVRFAIQGNYLAPVSDSLRNGAAVLDVGCGPGSWTMEIAGEYPKSEVVGIDMTSMFPTEIKPINCQFMRTNILEKLPFDDDSFDFIFMRFIQMGIEEEQWDTVLEELVRVAKPGAYIELVESDLERYRVGPCIANFDKRLTESLKARNMDPYVARRLDQLLIRHGLVNVKKRFISSPAGEWAGKLGQLTLQSWKAKAEALKPQLCMSWNTTQEQYESLMNACLSEADIHKSYENIHFAYGQKPILQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGM5</accession>
    <name>A0A8H7UGM5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Damage-inducible protein DinB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGM5"/>
    <dbReference type="OrthoDB" id="158485at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="entry name" value="dinb family like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007837">
        <property type="entry name" value="DinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37302:SF3">
        <property type="entry name" value="DAMAGE-INDUCIBLE PROTEIN DINB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37302">
        <property type="entry name" value="SLR1116 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05163">
        <property type="entry name" value="DinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="DinB/YfiT-like putative metalloenzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="20308" checksum="B21E355FD1721BC8" modified="2022-01-19" version="1">MVNSVPITTLLSLAHYNKWAYQRLLNGLSTVSDEDYYGNAGLVFRSLHGTLCHLYVADRNWHARFVNDYPDNYKESQLLWRGDDCYATPSATSSPWESAAQCWIDWLTKFPENTDLPKLNFLTSSGEQRKDQDSGLLMLHVFNHATHHRGQITAGVTHFGYPPIDGLDYYVYLTEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHP5</accession>
    <name>A0A8H7UHP5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHP5"/>
    <dbReference type="OrthoDB" id="2020070at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604:SF3">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="899"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="930"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1051" mass="119026" checksum="CE2843DE6C5B4EA4" modified="2022-01-19" version="1" fragment="single">MASFTSLQSTDTTMVSENFSKTEQHYLAHTIFNTDGSDTAALPQTERPWYGLKKISGPLPNWVENDPTVAVSHSHALQLHMQPGLNAEQLQSLIQTKSRPEWETATVTAIINFMQQDSLQSQIEAVLSQAILPKAIWIVCGTDKQSVAETMVSKYGRQQHGIKIKTVVVESGKQIDQRIAYGSSWLQVAQLAPSDYIWVVDNNAAPGSGYLKYLLQLAHTHEYQSALLGTSGIILPGRSEGHESQSGLLCIDNPPQSRSVDIINDVWLIRTQWIAQIYRESKPEALASPLGHYISQALNKYASIPSIVIPHEEGDHTLLADTLIAKRSLNSCQFLKEQLHQNTIWQDFLKHRTALSVVDYAKATELASSPSQDGSVMFVVDGPDQARALRPLFCRFHVLGKTMPYVVVTGQSRGMTAVQLRDTLEKHIGACANIDILDLDLDYGESSGLPTGESAPLAGQVSHDLTRLISALRPDLVLHVQQNANPVFQGVAVASKISNVMTITLPLDQIRHVLWMADLPMVALHHWHTISVNLIVITDRRPHSLSRLLRSASNAYFLGDKVSISVNMEQTADKVTRMLVANMPWPHGSKYVRHRIQKGGLMPAIVESWYPNSNDDYAIFLEDDVEVSPFFYLWVKYSILRYRYGHSSDRSDLLFGVSLYSPRNTEMGMQGRRLFNPDWVLNATSLDPRTPYLLQVPCSWGAVYFPEHWREFHEYVTARLIDLDTDARLNISVPESRSNRWKASWKRYFIEMIYLRGYTMLYPNFQNFTSFSTNHLEFGTHVKHERKAIEQFLVPLMETNTILHELPRHRLPALDELPVLDLWAKLSSNDELLERAKLLHSEVSACPRRPDNSNNFDPQDMLCPHPRPETEEQEVLEATPVVQGYVTTIYVTEYLKESPTPKPGLPGAAIDVPKQVPLPGDQNSAKDLDIDTTENEEVEEEVDAETSDLQEDLDNLEKLWLEQQKKNLQEGGNDQAQTTFIWQDDENEENLEIIDPEVEDEWNPDEWQDGLEVHDEFEEEDMTEIPDDAVTEEDPQVQGWPSPQPYPNLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UI04</accession>
    <name>A0A8H7UI04_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UI04"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2183800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="94" mass="10761" checksum="5B9045B157ACB040" modified="2022-01-19" version="1">MNDTATKPILNENQHSLQWSAFKPRAIASKPLGLTNFDNPLPFATLHADQDKRKWSSSDDLDEIGRKKHRNISLLFDDDTNMIADNVTYNPFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UI83</accession>
    <name>A0A8H7UI83_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UI83"/>
    <dbReference type="OrthoDB" id="435402at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033167">
        <property type="term" value="C:ARC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018606">
        <property type="entry name" value="Arb1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09692">
        <property type="entry name" value="Arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="474" mass="52994" checksum="29502A37083AD7FF" modified="2022-01-19" version="1">MQNTGEQEDVLRDRMLAHLERIKAQAQADHDVSDDDELFNQVAAGSAVADAAETPEAESPEEENSEISSKDQAGPSAETADIVMSTSKKKKKKKRKPKTAGLPEAGSTIPDDYVEKYNEDPELDIFNPARPVAQRVEFAMAKYRKNHKFSISKKNIFDDYLRFGGINTGPNAFQGRTTGADNLGDDLAEDDYEAAKAGIDSIEDDDEDVFVSFREVAQIYFGSRFIRQSKFIQLSEFQDAPEVVDAFLRYLQIRNVCPEYEQDIQAARDICDRARLELPRCKTLINLFPDKFNQACCVVFEGNQKDIMDFVPTWNTGDSKLQAIYGSFLADTVGMTKHEALSIVSPIVGDAGQRKVVNKKLVQRVRVVEIEGRNSNGADPCEEASEPVLLGSTSANTQHAVAGIYVKVVVSDYETSLTNYTLLMEKRISDQILPKIVFTADFYELDNGQWYIDQVNSIFPSFFLEEDEGSDEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UII7</accession>
    <name>A0A8H7UII7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mediator of RNA polymerase II transcription subunit 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_000294</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UII7"/>
    <dbReference type="OrthoDB" id="1868004at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021627">
        <property type="entry name" value="Mediator_Med27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13130">
        <property type="entry name" value="34 KDA TRANSCRIPTIONAL CO-ACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13130:SF4">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11571">
        <property type="entry name" value="Med27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2184385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="38565" checksum="69993BADB9A3E285" modified="2022-01-19" version="1">MNDAQAPADSIAKIDELLETLADTRASVRHLCRVTTDESRTVEFPQIFNERLRTVKGVLGRLGTEVDGAQGILEYAHNISAAKTFNIDSIVREESNDVMDFLNDDLQGNEIGDTNKEFGSALKQNASFLLREITIATKYTLKRVNEISEDRDPKRLDTKGKDTSSESGMITAFINDWIKTSSLSKHTIIQYAVEESNTLTGSACCLEISIPHVMKAYLSIQHDIEKDGVVFDNFCIVAYREEKPLWERSDYSVFSKINILALERLDEIAKKSSQKAIYCVLNWIASYHDLFTATCHKCQKRLLFNSPQFKYMPPTLRILKSSEDHDEQIRYLAYHDKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIY4</accession>
    <name>A0A8H7UIY4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_000763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIY4"/>
    <dbReference type="OrthoDB" id="69088at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2184850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="849" mass="96636" checksum="D8E1504F0543DF2C" modified="2022-01-19" version="1">MPWDDSECRSAMECTGLALSQLMGMRAIKGTFNISGVPSDIDGYISQILKNDINRSLCDLIAGCIGTPRQLEQKRDEILQMFFQFIYDAGIEASKSMVWLLCIVAAKLPDTVPIEFQKFAIKKFSTIGNPLTKSKKNEDLTKEQTCLANIISVYLEHASKNWQTNAEASILELLEEYIALFKEDQPMQTFDDQSDLRHYYVSYILSLIHISPQFTNDYTYMVEIFPLWLSQVAFSPSGLVMKHALDVAVMLDTIAHDERLDMKALIPSQENSIVTAMKASFTVPDLEPASVDLIDWTITLLKDSMNRANEVDMQIPMFLLQLRGLQSKLSAEELLSHLLFRLDRSSDAASNASKRYLLFHLISKFDEKWPGIFREVLHKIFSKLESVISKLIDERQPDALIIGRVLGSCSVIAEPCQDEVPIHTIKATLSSLQAYLAAEWKTVMSLFINHPSMTCRTSGYEVLRYSRFWELTKEPKSVHEILEKMTQTWFRQLSERFSAVHMRGEKYCALKMAFTDLVLEMSQDTNIAKLLIEYFADKIYDGALESFQQTRYYTFTPSENWALLETYRKQPSLLMGSATSPDKQMNRRRVGTRFKPRQARCFSHISNREIERSYQDEVYTQNIDDTTALLEKMAQQQHGIGHLIAARISAKWPSVVTPIEKYDQMLPQALPTDRDGLIGNTFRDHPGLYGLLRSSYHDGQVGIYDLLRSLLAYYVAFWHMSVVEQADSPLEHSVQLEGTIQLIELMGQTGAIETQLSNCSHLLADLDIRDIGNVLYTAIWEYTRRCSVGSEIPGLGTVTKPSSDMRAKNTIIAVEKIKGIVGQRIKSLSAVDIRADPKLEETAKKYRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJT2</accession>
    <name>A0A8H7UJT2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase III subunit RPC4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_002200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJT2"/>
    <dbReference type="OrthoDB" id="5836119at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007811">
        <property type="entry name" value="RPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="198"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2185765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="43729" checksum="EDA31B0BDF934860" modified="2022-01-19" version="1">MDQDRQSKPAGRASARKNAENGSESTGSAAAPKQLGSIKTETTTNGRLGSVNDDSKKTRGGASKMKFRPTIPTKRVKKEPTPSLLETALKTENGHPSGSRDAGRERGRGRGRGRGRGRGEPELVASGPFSLGPTAQARGRSFGAPTSTASFSHDDRDSFKPGAEGQDINALYGFNVDPMAPLAVPNKSTLEAWELEKQRKKDLKKEKKLKQSDEDRFGDAVKVKVEGDAHGMEGVTSSSEGTPNGENNHMNIDETEDTTTDLPFEDERLYFFQLPAILPRFKVPVEEPAVKAEGEDVEMKDQQQQPSTIKMEKEQAARNAPKIVDAEFDQAQEGRIGSLLVYKSGKVKLKLGSVLMDVAPGTDPSFLENVVVVDSKDQTRTSAVSVGNITEKFLCVPDIDSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKM6</accession>
    <name>A0A8H7UKM6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_007294</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKM6"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034089981" description="Serine protease" evidence="7">
        <location>
            <begin position="21"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="9">
        <location>
            <begin position="48"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="167"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2182364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="46537" checksum="26A2975F2D14184D" modified="2022-01-19" version="1">MVKTTLITTAVALLASYVAAVPVMDYSYNTGSLAPLYMPEDAEAVADSYIVVLKDHVNSENAMQHCHWVRALHNDNTVLSNLLDSNAARGLKHAFDLPKLKGYSGKFSKETLDQIRRSKDVAYIEPDTVVYASELERNAPWGLARVSHREPLNLRTFSKYNYEAEGGSGVKVYVIDTGINVKHVDFEGRAEWGATIPQGDEDIDGNGHGSHCAGTIAGKRYGVAKQAKPVAVKVLRTNGSGSMSDVMKGVEWATEQHQIDKSDAAKSKKKYKGAVANMSLGGGKSRALDTAVDGAVEEGIVFAVAAGNDNRDACSYSPAASELAITVGASTIMDERAYFSNFGKCVDVFAPGLDITSVWIGSDRATNKISGTSMASPHVAGLAAYLLSFTDGEATPKQIKDQILELATKGALTKLPKDTVNLLIYNNYTSSDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKU3</accession>
    <name>A0A8H7UKU3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell division control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_007475</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKU3"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000547">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016314">
        <property type="entry name" value="Cdc6/18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001767">
        <property type="entry name" value="Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc6 C-terminal" evidence="9">
        <location>
            <begin position="424"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2182544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="532" mass="58667" checksum="9591277EA3DA7CD0" modified="2022-01-19" version="1">MLLSKRNRTDNVSTAAPKTKRHSPSPCATDENQPLPTDGNDENAPILKTPEANRTKNLKQGNLTPVRSLAKSLEAAAVTSPNSAVKTLDFTKKDKKLIDVEDKTTDNLLQEAKALFRRTAVPTRLVGRTQERDTIAKFWEEHAIGNKSGCLYISGSPGTGKSAMLREIIADMEPKAKDVSTHTIKVCSINCMSVKEPKAIYAKLVAELKGPRALVETDVVKQAEKLLNGKTKAMKQIDHLLTKDQDVLYKIFEWASIPTSRLVLIGIANALDMTDRLLPRLRAKNCEPQLVNFNPYKVEEISAIIKDRLSSLNQEKDAPAIIQPQAIELCARKVAAATGDLRKALDVCRQAIEMTEAEAKKKATVTGKPAVLGERKTNNQSPAVTTTPKVTIAHVVKVMNVVFGSPSVQKIRQCNFQQKVALGVMVIMRATPSKHKDQMTLGRFQEQYTTFCGVSDIITPVSRTELNDLVSMLETTGLLTLAKAKEERQRKINIAVQDSEILLVLREVAALHSWIDDCLKKVGGKKLIQQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UMX3</accession>
    <name>A0A8H7UMX3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UMX3"/>
    <dbReference type="OrthoDB" id="10257263at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031179">
        <property type="term" value="P:peptide modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04794">
        <property type="entry name" value="euk_LANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736">
        <property type="entry name" value="LANC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736:SF7">
        <property type="entry name" value="LANC-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158745">
        <property type="entry name" value="LanC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR607822-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="417" mass="47023" checksum="D90F02B79B9A4926" modified="2022-01-19" version="1">MHKRYIENTLNTKDIDDFLEPHNLQRLLTTEIEHILARLPAFPVTGHSSSIYHGQTGVLYLLFHIHNLDPSFTVAGDPVAELCVMYLNAVTKSIGGIDSKHCGFIDSPVGVLALAACVYHIVLRKDYKARLYVEKLLEYQDIALKDQTSDELLYGRAGYLYALELVRLHCRDLIVDLISDQMRLDVIQKIIDSGHKGAVDDWPLMWRYHDRQYIGAAHGAAGIIGVLLQCGPLVDEWKEELLTVAKNICKLTLPNNNVPPHLGSQKDELVQFCHGVPGIIPCIALIERLYPSASNEFLSYAVNYADCIWHNGLLRKSVGLCHGISGNAFAFLELYLIKPQSIEYLHKAAAFCQFATDWRELTSRKVLDTPDRPYSLFEGNACLAWLLIDLWRINLPADQRTNVKERPGGFPCFTDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UN41</accession>
    <name>A0A8H7UN41_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UN41"/>
    <dbReference type="OrthoDB" id="2380110at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2185843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="356" mass="40414" checksum="3A1BB2F23040D095" modified="2022-01-19" version="1">MDTKLKKLLFRSSQIGVPTRWSTPQPPSEKSPVEERPRQSLDCPRVPSTPPRLSTPQHRTWRKPLPKEAPQMKVYTQPDYRKMDQNVTEALNALQACNFTDLPESIRSDFLREQRDAGLPSGQLRSLGTASSLYSKHYTQLPTSAPEATVQYPVRQTSRSYQSNVQVTTSLKDASRKIEQRYSRQSIDSSHSDNTSGEESHGPPTPRHSFSSMSTSPPLQTSGPPEPPKHNFDIPQIVTTLQKSLPNSPIEPEHKTNVPADYNYTDKQVDRVMYLRPKVASIKRNGSVKRKNSARRHVSLRRHVNTVLAGAFDEADDEWENESDEDDEDLPLEVYTRQPWQPGLHMLSHQTTLKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UNA7</accession>
    <name>A0A8H7UNA7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_002476</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UNA7"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="156"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="373"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2186038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="57637" checksum="CCAA8351C9ED8ABC" modified="2022-01-19" version="1">MSIPLTWTKLSFQLSKCWRSRLVNTQKPQTFSTSAAVLANKGKRKPNYSTLTKHLKPDGLTGPQRRNVLREKQRTSRGSGPGKYIPVTKRLEPIRSDFRARPAPSESVSELSQRLADTRFDGMGLKPQVLQAAVSGPLKDIDSPIPTEIQALAIPKILTSSSHHFLCAAETGSGKTLAYLLPTIHELKKQEERNSKLRRLDHPRAIVLVPTRELVTQVLRTCKSLSHVAKFRAEQLTSRLSRSRLVDSLATSPVDLLVTTPTSLLSHVEDGTLSLADTTHLIIDEADTLFDSGWGDECKNVLQMLQKIQESREIKQKVIIVSATLPRSVSTLLDETFPKLIKITTPSLHKSLPNLKQSFVDLSRFNGNRQMGLIEVLKKNIKDDKTMIFCNTKKSVELAHRFLQTKGIETLALYKDAPMSREETLRHFSEPTREDTDARNNMLICTDIASRGVDTTFVNHVILYDFPSSVIDYLHRVGRTARAGRNGKATGLVGRKDKMLADRIQRGIREGTVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UPM2</accession>
    <name>A0A8H7UPM2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UPM2"/>
    <dbReference type="OrthoDB" id="9942608at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461:SF5">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2186384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="416" mass="46828" checksum="2C227D899455A89E" modified="2022-01-19" version="1">MYEQALQSLKEAFPTVDPVVVEAILESHRGQADRCFEPLLRISDPSYKPDPPQRQQSPRSQHSERSPDQPQQQEEGEEQPLSPEEQMRRDEEYARQLALEDERERVRLHQQRGNARPNNRPPAPERENSQGFMTQFEQELPVIKERVMEAGTAAKNKMMQWYSQIKEQSQQSSNPNTMPPTNAQYRGLSRDDRDDLLSGDMSALHLSENDVYTRTTGQPFPQRQVSDASDWDDRLGKRPGQQQGSPQSNTVHVNPPSSGPRQPQYKTSTSMDQLTADEELARSLAYEEDHFTPPPPMPSRPSRTGSVNSGAPVHSPAQNFSTSPKANDSPVSRSIEVNPPADEDNEAVKPYAISPKPNATTENPSEPIRTEQVNKKDLSDVDDDDIGLIDVDEDEDDDLETTKATSKPNEKAENQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCK1</accession>
    <name>A0A8H7PCK1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_009036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCK1"/>
    <dbReference type="OrthoDB" id="2384637at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024368">
        <property type="entry name" value="Ecl1/2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12855">
        <property type="entry name" value="Ecl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="123" mass="13326" checksum="116EBD19694D3E07" modified="2022-01-19" version="1">MSNLNWCTFCDNAINPFSNSLYCSEACLRGDALNHHPLLGYDFSELQDFPRRSSTSSTSQSPALSISGLSSASSSPIPSYTLPSALPPSSQMTTPQLKLSPPLFELNQPALVKRPMAKTSLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCM8</accession>
    <name>A0A8H7PCM8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-hydroxyacyl-CoA lyase</fullName>
            <ecNumber evidence="9">4.1.2.63</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_009083</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 2-hydroxy-3-methyl fatty acyl-CoA = a 2-methyl-branched fatty aldehyde + formyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:25375"/>
            <dbReference type="ChEBI" id="CHEBI:49188"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
            <dbReference type="ChEBI" id="CHEBI:58783"/>
            <dbReference type="EC" id="4.1.2.63"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:25376"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an (R)-2-hydroxy-long-chain-fatty acyl-CoA = a long-chain fatty aldehyde + formyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:67444"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
            <dbReference type="ChEBI" id="CHEBI:170012"/>
            <dbReference type="EC" id="4.1.2.63"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:67445"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.63" evidence="9"/>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCM8"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106359">
        <property type="term" value="F:2-hydroxyacyl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001561">
        <property type="term" value="P:fatty acid alpha-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02004">
        <property type="entry name" value="TPP_BZL_OCoD_HPCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000006">
        <property type="entry name" value="2-hydroxyacyl-CoA lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000038">
        <property type="entry name" value="2-hydroxyacyl-CoA lyase 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045025">
        <property type="entry name" value="HACL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006721">
        <property type="entry name" value="PRK09259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710">
        <property type="entry name" value="2-HYDROXYACYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710:SF2">
        <property type="entry name" value="2-HYDROXYACYL-COA LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="13">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="11">
        <location>
            <begin position="198"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="12">
        <location>
            <begin position="393"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2171422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="567" mass="60858" checksum="E9DACD950BAF0103" modified="2022-01-19" version="1">MAGDKLSGSELIAATLKHQGIDVIFGIVGIPVIEVAEACIRAGIRFIGFRNEQSAAYAASAYGYLSGKPGVCLTVGGPGVIHALAGIVNSQVNCWPMVLLAGSSDTDQIGMGAFQELDQVEACKPYTKYATRPASLGAIPFSIEKALRTAGYGRPGACYVDLPADFIQASIPDDKYIESIQVPPVQPAPVYLADPAAVKTAAQTLQSAQNPLIVIGKGAAYARAENELKSLIETTNIPFLPTPMAKGLLSDSHPLCSSAARSTALKQADVVLLVGARLNWILHFGHSPRWSKQVKFIQIDIEPEEMNNNGAITIPLVGHIPAVVRQLTQSSIPRLPDSHSFLRTLQSAVKTNIQKAAAKSKQGDETAVMNYHSAYDEIKKLLPAKDVVFVSEGANTMDIARSAFDVHEPRCRLDAATFATMGVGMGFAIASQVYYPEKRIVSIVGDSAFGFSAMELETAARAKLPLLILVINNNGIYHGLDHNDYESSRENNNLPSTALSPDTRYDLIAEACGGRGWLAKNRKELREAVKAALATRDTTCLINVVITPGGRTKLEFGWMTKKSEPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD17</accession>
    <name>A0A8H7PD17_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="13">Aconitase</shortName>
            <ecNumber evidence="13">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_009085</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD17"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01584">
        <property type="entry name" value="AcnA_Mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="14">
        <location>
            <begin position="71"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="15">
        <location>
            <begin position="587"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2171424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="786" mass="86018" checksum="0DDD4C58E3A358A3" modified="2022-01-19" version="1">MTFSRLMHRVDVKPAFRQPTRKHYAKLTGTSVGDRVTMSKFEPNRFIDYKTMDQRLQIVRNRLNQPLTLSEKVLYSHLDDPHNQEIERGKSYLLLRPDRVACQDATAQMALLQFMSAGLPSVAVPTTVHCDHLIEAEVGGEKDLPRAMSANKEVYDFLASTCAKYDIGFWKPGSGIIHQIILENYAFPGGLMIGTDSHTPNAGGLGMAAIGVGGADAVDVMANLPWELKCPKVIGVKLHGKMSGWTSAKDVILKVAGILTVKGGTGAIIEYHGPGTEAISCTGMGTICNMGAEIGATTSLFPFNQRMADYLKATNRENIAAYAGQYAQNLRPDEGAKYDELIEIDLDKLEPHINGPFTPDLATPLSEFKATALENGWPKEIKVGLIGSCTNSSYEDMTRAASLAQQAVDKGLKVRSQFTITPGSEQVRATIARDGQMDTFVDAGGVVLANACGPCIGQWKRKDVKKGEKNTIINSYNRNFTGRNDANPGTHAFVTSPEIVTAMSFAGDLTFNPMTDSLIGADGKPFKFQEPVGRDLPAQGFDPGVDTYQPPPEDRKSIEVQISPNSQRLQVLQPFPEWNGEDIKDAPILIKVKGKCTTDHISAAGPWLKYRGHLDNISNNMLIGAVNAENGEVNKVHNILNDEYEAVPDTARQYKEKGISWVVVGDDNYGEGSSREHAALEPRYLNGVAIITKSFARIHETNLKKQGMLPLTFANPADYDKVDPNAKVDIVGLQNFKPGEQLTLRVKNPDGEVEEIPVNHSFNETQIEWFKAGSALNMIRKKLASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD24</accession>
    <name>A0A8H7PD24_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="7">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_008042</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="7"/>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD24"/>
    <dbReference type="OrthoDB" id="407390at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF25">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="10">
        <location>
            <begin position="40"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="9">
        <location>
            <begin position="242"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2171662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="415" mass="47491" checksum="6F7870A73E3BF5F3" modified="2022-01-19" version="1" fragment="single">IEGSSLSICHQRRHNTSAPKSFYHNEVLDRYVEQSVNPNTVRQLVFFGRHMTDDRLIKSANYVRKEITIRLAHRIRDFQKLPFIVGTNPHIELIYRMYWQAFEKIRQYPPVKTLDDNEKFCDMLKSLLSDGLFVIPELALGAMECSGFIAANTFDRFMNTMLRSRISRRVIVEQHMAITANHNAVWDEEGYIGIIFTRCCAREIAEKCVSLSTEHIKKAYGKTVNVMMDGDARNEAIFAYIPEHIEYILYELLTNAMRESIYNGDSESRPVRLTVAQNSTDIMFRVSDQAGGIPHEVFKTLWSYSHAPTGFENFKKIKKLGGSMAEREQQVYGEKLGFGLPMSKVYAEYWGGELSVMTMDGLGTDAYVRIPRLGNQAENLTLDEIDEAEYTHRPDNSIQSTNGYSTRPSALVVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDX0</accession>
    <name>A0A8H7PDX0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_008312</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDX0"/>
    <dbReference type="OrthoDB" id="2406834at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="221"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="690"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="696"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2171586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="776" mass="86551" checksum="F1114BD29ADD662A" modified="2022-01-19" version="1">MPNGDGIDGSMMADNESLTPSRPSSPVQNYNESEQQSDSFSNSTSVQDMPRSGEKAVENLRNRIGGLSINQGKTHPLLSTNDTLWSSKFTTSGPSVEPSLPSYYSGVLDMPTRTIQEHLIEIYFRRHAQLLPLFSRQTFFRHLSDNGYLISPLVLNAMYAHACTYEHDLQEHADIFFDRARSLLEDFLDVPRISTIFALLLMATYEIQLGEDKNIKRSCRPSIYAGMATSMCLQMRLQNQAYRPQLTDFDKELRIRAFWSCYNLDKEISLASQRPAILSHKQVSISLPTILPTDEDPMAIDAFISTTRLMIICEKFLDLQCSSIGEPSYMLYEDNTTGLLEDLSNWLTSLPKPLTWTPLPEISSPVPAKPPQTAVIATLHLHYNVLEHRILKSTTNQTSKSIHRRIRTVANTITQLAHFLVNDIALLANYDHCAYAVLLAALTHAADLRHSTPQVSLQSEVQLRRSVAIIDFLLENRALTGSGGFSSLIGSLIDISEVEDMRSLSAHQMYEKTKTYLENLIQGSSRLQPHGLERQGLERLQYTKPTVLHHFVDNELRQPAVSKPTTSLPSTTSLPPIEAAKLLEPAHYTFELISVEDNWGYPNATRVPASVRTLDHQQPTPVTSAAMMDRRHVTPPRVLRHYSPPEMDTPPPDPRTLWTHSPNNLRPNTASEDTILYSIAASATGWVDDSEKWSGGHQSQSTLPISSSASPTNLPASNTIPLDMGIQSSPKYLLPNRGDLGSVPPSVVLSNGSASQLLPDQHSHALIDHMHIDNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PE75</accession>
    <name>A0A8H7PE75_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PE75"/>
    <dbReference type="OrthoDB" id="5563539at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="347" mass="39453" checksum="58481DDA90AEEF5B" modified="2022-01-19" version="1">MKAYICVDYLSHDWELGDLQYAHLQTRQQLAKVTASLSNLNEPENFREEQRLVGERNRLRRFENTLWRQISLRCTDQLGSTNIKINPMDINWQRDSDITWLYGPLYRKNDDDDSFEMRHAAADGLLTPSTQSSATGYSSPTMSCLSPATSTTSSFDTLDEVASKLKPVLKRSPNPCPLTDWSLRHPNSTKASEPQEAVRHQSWPREVVHFNPDVIEVQFLPESPIIQAFPDDGVWDSDDEDNVVYKKLISSGQSAMVAYWKDLWTNNYDLDHGFDAASIEGTIDQPPESLTDLIMLLVQMIQSLIALCASWFLYQSISAGIAPIAWLTKLKTNTKKKQTNSRSLSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PF25</accession>
    <name>A0A8H7PF25_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_000098</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PF25"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001921">
        <property type="entry name" value="AAA ATPase domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="48"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="284"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2172751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="507" mass="55351" checksum="8E655EAD4E9519B4" modified="2022-01-19" version="1">MPVPPCKEWCASVQQDMGGVDDLVKDIVNQISVLDRFGTQQPRTQGLRGKGTMLIGKPGTGKTALAAAIASQLKEKRDEVLDINSLVCIIAECSSLPYEVVNCPDVFRAEEGASEAIISRAFRGRASNKLSILILDEVDMIASHVAIKKAGVEARTFSVLVDELDRINRPTSSHQIYVIGEVAQITHSFVPADLQNLCRQVVLMLVQQDASCADSTKQSFAQLHHFESALEFIKPSNFVEYKSQLPNIRFKDLFGIDNIIQQLKVSIIDPFRDRSSYLRLSITPPRGLLIHGPPGVGKTALCCALGSEMGINFMLVEGSQVRSKIVGESEKNVAKMFSQARANSPCILFIDQLDALVPKRGTSSSSENTSDRIVTGFLTELDGFFTKSSAGDPSNDVLIVAATNRPQVIDPAIIRPGRIDEHISIPIPGALERKEILQGLSANIPMSIGADDLAQLAERLEGWTGSDIDNLCREAALIALREDIESDKVLLKHMIQAIEVDRPAMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PF81</accession>
    <name>A0A8H7PF81_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CWF21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_000191</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PF81"/>
    <dbReference type="OrthoDB" id="10267305at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21373">
        <property type="entry name" value="cwf21_SRRM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="8">
        <location>
            <begin position="54"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2172841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="308" mass="35375" checksum="AE48C62CE98B6519" modified="2022-01-19" version="1">MYNGIGLSTPRGSGTNGYVVRNMSSLRPQRREDRSFDDLKSKGPAIKQPNQEILLHDRKRQIEVECLKLRMVLEDDGENEDSIETKVSELREKLTAKLDTIKPKDAKSLHTHETHQLSEAKQHENQKMMKALGIPETGYVEGAAFDRELQEKLKQERIAQREADMAEREARRKQARSEPSRHSSSKRGRSPPARRHRSRTPERKQRKVSARRDSPSVSRSRSPSRSSSKSPIRGGERGRRASPPRGRRGRSYSVSSRSDYSSSRSRSRSYSDDSRSRSPVRRRSRSRSYSSRSRSYSSSRSRSPANRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFW0</accession>
    <name>A0A8H7PFW0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA repair protein RAD14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_004576</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFW0"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21077">
        <property type="entry name" value="DBD_Rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.530.10:FF:000003">
        <property type="entry name" value="Dna repair rad14 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022658">
        <property type="entry name" value="XPA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00753">
        <property type="entry name" value="XPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="12">
        <location>
            <begin position="146"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2173202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="285" mass="33293" checksum="F44550240A4B22EC" modified="2022-01-19" version="1">MSQPLSPEVLQKIEENKRAALAKLAQKKRERESEGNEVSSNNVQDGGDSRASKRRARWAKPIFDYDLSQMVDTRGGFIADEGNDADEFRKKLEEKAHKVDMNPARSLDPNQNPRCSECNSLDIDPHFHQIFNICVCAACKEKFPDRYSLITKTEAKEDYLLTDPELRDEELLPHWSKPNPKKSTWNNMMLYVRFMVEEYAFKKWGGPEALDAEWEKREKYKKEKKDKQFKEKLKDLRKRTITSTWEKRRDKAHTHEYGDPVQNPSDGTTKQTCKICGLEIETEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGX2</accession>
    <name>A0A8H7PGX2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_005182</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGX2"/>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="521"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="368"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="232"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="471"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2173762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="591" mass="65976" checksum="B8FE76C89E11370E" modified="2022-01-19" version="1" fragment="single">SKSLTAEAIESWVENIQHYQKTVEAMATSKLDPKFKDDLNRVNDWFRLLSEPERTTTLYSIVQHATQVQIRFLIAVLTKMANEDPLGALLLSGPSQEKDPFMSSSAKQSELESQQRLRSAYPARNKLASRNMYRQSNAFSEPDELSRRRQNDLLSGRLLGISDSGILYEKAKALQRAAIGSNSISSVLNPSYLKSNGPPPPVKRPSSMSNLSSPSSMNIGNDWPSALPKADSSSGGTVSARSSLADSSSTHSTLGGHSSSSEGLSEWSPLLAPKKHLQDQSFDCLDRIDRIDRLDRIDRLDRLDRPAIYDSKWAPAGTRLENNNEQDTNCIPKPVLSSIDTMRSSLYNNTEQKHRRISEEFIGILEEPRPTSSMLSNHNDSMRFLDTDPKSRSKPSPILPVKYTRQMSNSTPTGLRYSPLLSPLPSPKPHSRSSNRSTSPPFRAWPPSPASNTNYTQFLNPNDGLNAVEYSSDHSDGSVESHNEPGHLTEAAMNRRRRASAARAAKDKIAAETIDFELMSDVQAWLRTLRLHKYAYAFEGLNWQQVVRMDLDAMEKAGVNTLGARRKLLKVFENVMHHCDQNVSTKLDIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIA6</accession>
    <name>A0A8H7PIA6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_004323</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIA6"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF156">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="13">
        <location>
            <begin position="25"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="14">
        <location>
            <begin position="287"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="11">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2174300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="407" mass="42954" checksum="1E017E6EE52B477E" modified="2022-01-19" version="1">MLSALKKPTLVRGFATQASRGLNEVVIVSAARTPVAVFNGAFKSLTAPQLGAIAAKSAIERAGLQPDQIEEAYLGNVLQANIGQAPARQAVLGAGCPESTEATTINKVCASGMKAIMLATQNLQLGMRDIMLAGGMESMTNAPFYSQRNIAYGHQQMSDAIIKDGLWDPYNNFHMGNCAENTAANYNISREAQDEHAIESYKRAAAAWKNGVFDAEIAPVTIKNKKGDIVVKEDEEYKTVKFDKIPGLRPVFKKDGTVTAANASTLNDGASAVVLMTRQKAQELGIKPLARIVSYADAATKPIDFTIAPSLALPIALKRAGLEQKDISLFEFNEAFSVVARVNEQILGLDPSKVNVAGGAVALGHPIGSSGSRIVVTLTHLLKSGQFGAAAICNGGGAASSIVIQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIN2</accession>
    <name>A0A8H7PIN2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidase FUB9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Fusaric acid biosynthesis protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_005765</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIN2"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000056">
        <property type="entry name" value="hydroxyacid oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF149">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="79"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="288"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="311"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00083297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2174707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="381" mass="41633" checksum="10B4CC9FC44B4F86" modified="2022-01-19" version="1">MASAPVSLDDFEQHARKILPPSVFGYYYSGADAEWTLDRNKRAYDSLLIRPRILVDVETVTTATTILGQKIASPICVAPTAFHGMAHDDAEKATARACASLKTCYTLATYSNTNMEDAYAAAKEKTKKQDPLHWFQLYVEQDREATKQLVQRAERAGYKALVITVDRPRLGRRLADLRNAFKLPKHLTLANFAVDESRSGAGAYAGGAIDASLSWKDIEWFKSITKLPIVIKGIFRGEDAKLAAKAGVDGIIVSNHGGRQLDGCPATLEVLPEIVNAVKGTKVEVYVDGGIRKGTDVFKAMALGARAVFLGRPIVYGLAYQGEAGVRQVLSLISYEFRLAMSLAGCTDINKITSDYIIPAEELSLAKSYAKYYPKTATPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIT1</accession>
    <name>A0A8H7PIT1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_005759</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIT1"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14081">
        <property type="entry name" value="STKc_BRSK1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="70"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="438"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="560"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="637"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="844"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="697"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="844"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2174701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="871" mass="97990" checksum="65CEC56B1965172C" modified="2022-01-19" version="1">MTVEPIPSRSHSQTQYTSHYSNKAPVNKSQSTHNTSQSAQQRSGRRHSTLSLSSTRSTSRERPKKYVGDYCLGRTLGKGASGRVKLGTHRVTGEQVAIKIINKAYLSANPAIDKAVKREIAIMKLIHHPSIMTLHDVIDDDDSPELYLILEYMEGGELFEYLVSEGRLPEKKARSYFQQIIYGVDYCHKHLICHRDLKPENLLLDRNLDIKIADFGMASLQPIGSLLETSCGSPHYASPEIVTGRPYDGSSSDIWSCGIILYALLTGHLPFDDENIRLLLKKVKTGRYVMPHDISYQAQDLIRKILVTDPAKRITTEQIKRHPWFAQDIPPKIAQMPEPPSSQEIDRPVKDISQIDDRIVETIKFLWGEEKTEAVVDALMGKEHNMQKVTYVLLRRHAEKYWESRHDDDDESFIDTSSRRYSSMSNMSRRRMSMHAEFTSSTDGLTPQGFKPDVRRKSSPSTYRRASIGPSEAARQYPLIHPTELPPSPMPSPRIRSKSGTSRGEINSSQIRIDIEAYSGRRHSTKETSRRFDAKSIPPSPKPARSLHNLFSVATLGKKNPFAGMLSDDPNAKGRERQRRNTQPHQEATINDKSTAEQRKRLHRLSMPMLDIGSIGFDRKSINFSLRRKEASVWKEMASPTSSVMTPPISPSPPTSPSPVRNKSGVRNNLGQDIFFPIPPPSKSPSGTGYITPPGSHGSSANELTNTTSNVSQPTEDATKAANKIPWLQNLFFFKQPKIVSVTCEALDCHQALRKVQDAMREGMEAKLQSKPDKDGHTRYRGELRIFYADKNCKVKFKLEFIVCGLIDGHRKLFRVDFIQQQGDALALAAATKNIQQVIDRRGSCSTSGFSWSTSTTEDNPSTFHDKLKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJW8</accession>
    <name>A0A8H7PJW8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName evidence="5">RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_001131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJW8"/>
    <dbReference type="OrthoDB" id="272392at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055207">
        <property type="entry name" value="POLR3C_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039748">
        <property type="entry name" value="RPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22536">
        <property type="entry name" value="WHD_POLR3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase III subunit RPC3 winged-helix" evidence="6">
        <location>
            <begin position="124"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2175484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="283" mass="32322" checksum="350FE76CEBB608CC" modified="2022-01-19" version="1">MQAVIDEATFTINRGAGQVLRLFLEQCEEGGLSGSTKDESRPTSALHVASVLPHDMLTDSGLAQDEDSRDAGQSTASDIVTEYFELLRQCQSKFIKRSEHGGSNFFVVDYKSIRQYMRSKLLYKILKSKFGQKPCRIARILIDKGKLEEKQVQKLAMLPAKDTREQLALLCTHGICDIQEVPKSADRAPSRTIFLWFVNLDKCYKEILMDLYRSIANVRQRSRHELAIRQRLLAKMERKDVSANQNLLSEADKKAVEKLNKVMEKLAVSEARLDEMVMIFRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PK65</accession>
    <name>A0A8H7PK65_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_005794</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PK65"/>
    <dbReference type="OrthoDB" id="10266662at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF4">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2174736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="636" mass="72345" checksum="C3CD2E49ADEA3B3C" modified="2022-01-19" version="1">MAKLKKSTVKFQKHHLKQEIERRKKHKKVQQAYKRRIDSRNNGTRPGADRSNDGENAAKEESEQTKKPGVPDISKININDFMQVDCLLGDEDALELNDDKESDLDILDKFKGVEDIALPEQVEDEDEESDAEMDELDDGSITVTKEMLQEWIKKLEKSPKINSLKEMLLTFRAMSLMDEKYNATCRYQVNSETVFMKILATVLDTAPLLINANLVAKKVGSPASAPKWSELQPVTRLYCNSLLRILHDVADDELYQVLLEQLDSLVTYIAIFPQARKAYVKILLKLWSTPAISSSVRQQCMSNLCNMASVPINDKATGKKSTMLGYVLKCVYITYARRAQQVDAESAVAIEEMRTSSVKVYRANDKHSLHHALVYIQLLTQYLQTATKSQTKDTVKVVLSWQYLNCLKFWSKVVGTICGANAQDGSKPSQLAEAIYPLVEISIGLIKLMPSVQFLPLRFHLIRMLVDLGKQTGTYIPLAPYLFELFNIDEIRKKAKSVSMPPLEFDLIIKAPKEYLHGKVYQDELLSQLHSCLIEYYACYGLSIAFPELAVTAIVELTAQEKRAKNPKFMRQLHTLKEKLEEQTRYIQQQRSAIEYNPTNQAEANAFLRNATIEQTPMGNLLKSMNRAKANRKSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PK88</accession>
    <name>A0A8H7PK88_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PK88"/>
    <dbReference type="OrthoDB" id="2242808at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="229" mass="25822" checksum="FF1870509F94C418" modified="2022-01-19" version="1">MSLSEVNSYPLVHLPFELILHILSFLPILDLYSLRKHLPIEYESYIDTMLLRHPNLDSRRLVLRVSAPNTMYTYHPGTSLSTVTQDIYDECADTATDFPSSRIIKMQIRRFGPKGIELLPEEDQWFRHADAVGVAVVLLEDDNRVAKRSLHAADPRKGWFAREGYFDGGIAFELGMTKTDNVSANLHGRTKCAVIQWFGISTQALLTVGTNTAFPAILRAYLIFSPPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKF0</accession>
    <name>A0A8H7PKF0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_001203</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKF0"/>
    <dbReference type="OrthoDB" id="2284405at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000002">
        <property type="entry name" value="Serum response factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="77"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2175556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="196" mass="22010" checksum="C5820E57E22C4E1F" modified="2022-01-19" version="1" fragment="single">KILYTLPIIQSSTYPNTYSHLQSFVGMSQLNQQQINQNVSGQSGQRLTIDERLQKNEDLGLDDDDSDDGDSKPEKRTGRRKIKIEFIEDKSRRHITFSKRKAGIMKKKYANPLPGLTDKLYFLKRNQAYELSTLTGTQVLLLVVSETGLVYTFTTPKLQPLVTKPEGKNLIQTCLNAPDVTAVSAEPPSPVTEIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLU0</accession>
    <name>A0A8H7PLU0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">INT43_005606</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Microsome membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLU0"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="16">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2176372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="123" mass="13608" checksum="7674658B4231CB0F" modified="2022-01-19" version="1">MSTFTHEQVATHNSKEDLYMIVHNKVYNITEFVDEHPGGEEVLLDEGAKDATEAFEDVGHSDEARELLEKYYVGDLDKSSAPVKPVKSNTTGSSSSSASQGNPLRIIVPLVILGGWVYFRFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMU8</accession>
    <name>A0A8H7PMU8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007552</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMU8"/>
    <dbReference type="OrthoDB" id="47374at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000006">
        <property type="entry name" value="Putative n-alpha-acetyltransferase 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2176898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="165" mass="18508" checksum="768ECF0EB93973CB" modified="2022-01-19" version="1">MAPTVTSARISLGDLTPNNIGQLRVLNKILFPVNYSDKFYKEVLEVEEFAKLAYFNDVCVGAVCCRAEPIDTNDKAAKLYIMTLGVLKPYRGQGVGKKLLNHILEHAAKDKDSNITEVYLHVQTSNQEALSFYKNQGFEITGTTNDYYKNIDDKDAHVLTKSVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMX2</accession>
    <name>A0A8H7PMX2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMX2"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="105" mass="10887" checksum="2270CDB521011A9A" modified="2022-01-19" version="1">MNGLSSSITSGVGDEVLGEDDSGSSEGAVTEVADFGWSSVSHISHRCILGWFMKVQTGQVFSVGAGADADADADTTDSPELDVVICMLAGLNTPQSWHFSISSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNF5</accession>
    <name>A0A8H7PNF5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007969</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNF5"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF56">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="3">
        <location>
            <begin position="83"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2177312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="372" mass="43285" checksum="1CF076ACEBC35FC1" modified="2022-01-19" version="1">MAQVATLPEQKKQGWRTFSTTQDNYNAATVQWPEKIEGPSVWDGKYLEKHPEEWVYQLNEAEIKEIDAAVKHFFTLNRELITIDQESFPLPEFGKVLRRHREILLQGRGFTLIRGFPITSYKREEQAAVFMGIGTYLGYRKTQNAKGHVLGHVKDITIGSQTKSVYDENDPTTRIYATRKAQPFHVDGTDVVGLLCLQVSEEGGESSVISSHTVYNRLKELRPDIIELFKEGWHWDKKGEHGENDKPYLIAPPMTYYENKLFTFYGPHFWETVPRLGIDVSEEKFEAMKYVQELCEQEALNMWLEIGDMQFVHNHQLLHARSSYRDSPEKTRHLLRLWLVVPTEEGGWEMPFAQREGVYFYNVDHSVPLEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PP32</accession>
    <name>A0A8H7PP32_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcium channel YVC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_008000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PP32"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF1">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="293"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2177343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="682" mass="77108" checksum="48D23A50AEFE8977" modified="2022-01-19" version="1">MSDEATCLLPADGLQTDRLVQDLIDEVKVTVNSKFETSIPHSALQLPEINVTVILPIIKHWATRKDPAAVFCWLSARSDFLKESYGDLGNTKVFQTRADVCELVAIRLLKAYSPDMLIFVLTHDFVPTQVSKNSSSNLLSFDRGKNHIETSSMNALEVAIEGFAKNFVSSPLVQRMTSGGAILSSLLRQLVSWLIIITRTHLNWSQLTLSSFPSDHPSSRIKWAYTLPSQTVDKQKVPLPIKVATLNEAEPHILRLSRLRVPRYKAFFETLTYCFFVFCYSMILYNDICQFLSGWEVLFDIFVIGLTINEITQFANAPSYYFQNLWNAFDVGIFAISFAFIGLRLQHFVTGTDTCSLAYDVLAINAMLLWPRLLSSLDSMPFFGTFLIIIRRMLIDSTIFFTLLAVFFLGFLQTFYALGRSTYGWGEIGELMLRIMLGSQFLGFEAAANFGIFGPPVMYLYIAISSLILVTILIAIFNESFSIEEIQSDELFEYMPPFNLFQVIVLLPLKQLIPAKMFLKLNRAIMCIVFLPFLLLIYLWEVFSYRLNKDNAQQLMVQRTGSIKPMYRRTLFRARTRSSTAVPRISLASAVPPRKMPEGPSTSINIDENAGGKYGSTSRVGKQKQEGSSATLFDSPTEEFDAIPTSTSRTNDKDAQLEEIKKRCEALEVQVQQLLAIVKQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PP68</accession>
    <name>A0A8H7PP68_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003101</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PP68"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF17">
        <property type="entry name" value="NADH DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="41"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2177854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="323" mass="36266" checksum="346845F053A9D5A3" modified="2022-01-19" version="1">MSALKHLLSRPAVSTRAVAQLNNARTVHNTKTRTLTHSQGRIVILGSGWAGFQFMKDLSRKDYEVTVVSPRNYFVFTPLLASTSVGTLEFRCATEPVRSYSHNIDYHQAWCDKIDIENQVIHCTSNLDDNKGSPFTLDYDKLIISVGSYSNTFGIPGVKEHGHFLKDIQDARRIRARVLECFEYAAQPGLSNKEKAEKLHFAVVGGGPTGVEFSAELHDFISEDLSRLYPQLMAHVRMTLYDVAPNILSSFDSNLSAYATKKFARRGIQVKTGRQVTEVLKDRLIIKQEGEVPFGMLVWSTGLMQNPLVESCQSALKDERSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPV9</accession>
    <name>A0A8H7PPV9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Yos1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_002995</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the YOS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPV9"/>
    <dbReference type="OrthoDB" id="15356at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013880">
        <property type="entry name" value="Yos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858:SF0">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08571">
        <property type="entry name" value="Yos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034840813" description="Yos1-like protein" evidence="9">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2177748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9052" checksum="C34CD4A8676343AA" modified="2022-01-19" version="1">MALGLGQLLYVLLLFINAIAILSEERFLGRIGWSAQQEPGFGDQGQSIKYKLVNLISAVRTLLRIPLIGINVLVIIYELLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQ57</accession>
    <name>A0A8H7PQ57_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Trafficking protein particle complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_003130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQ57"/>
    <dbReference type="OrthoDB" id="10256906at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055505">
        <property type="entry name" value="DUF7077"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056916">
        <property type="entry name" value="NTS_TR130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022233">
        <property type="entry name" value="TRAPPC10/Trs130_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056913">
        <property type="entry name" value="TRAPPC10/Trs130_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23274">
        <property type="entry name" value="DUF7077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24967">
        <property type="entry name" value="NTS_TR130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12584">
        <property type="entry name" value="TRAPPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23036">
        <property type="entry name" value="TRAPPC10_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Trs130 NTS" evidence="8">
        <location>
            <begin position="334"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7077" evidence="7">
        <location>
            <begin position="680"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="TRAPPC10/Trs130 C-terminal" evidence="5">
        <location>
            <begin position="1021"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="396"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2177883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1189" mass="136593" checksum="F9ACA55D61CCE248" modified="2022-01-19" version="1">MQSKKVTITYYDEYGVWPHLADELSSRLPLRNLHWTSSVQRPLRSIQSLDVDLKRFTYDSGPQPLLSTQTPYLNLYFVACDDNDTYRNTVRRQIKSWVDVISTKKNQEWLLVYVAGQETRKSGSYLGLKTSVYDKIKSDFNIGKRDRCVYLRSATSEHADSEDWVDFINKMKDGIITSFDSQVQQYQEDTRRLDLQRQMPGWNYCTFFILKEGLAHTFETMNLYEEALIQYDELEASFFQVLKDKALAWFGHVGGIAPGDDSANVLDFKRKPYRELINKNTISVFDFRSYLFARQCFLLLKLQRPIETCARAQLFISNMTVTLKENEMPVDDYLESWIFSACTNVVNECEPIANHIATSNPDLAPMYNAAKADLLILARKQMDKIGVKHGHLPDVNPFNMHMDKKSPEQKRYSSSEVNSGDKEPMTNQKLREAVVSSEAFDKMYMALSTRAIKGYDLSNRVRSALWVHGDIASFKFARAKYEEAARILESMTWRYGDQRWTYIENALLRKCAEAQKHLGNRRQFLECVLTLLKNASELNSEEAEYYTNELLDNVQNMEEEIHRQFSPIFIVSDVVVVDDVASVDKTNITICVHNKLPKALHFNKLSLSLVGNEPEHIVFETADRPLVPGPNTFNLTSQTSAAGEYVVETCHLQIGKLSFTHNFLQEGHDKHILRLNHDVKQLQVLIEQPTSVILGEKQNFAVQVSTKENGIKGGRLVISSLSEGLEIQKVTSYSANIKAENESASSDRIVELIVSEDGVIELPQCDAQQRIEFLVPYDGPWNESQFRLRSKVEYITEQGEERVFHAAEFVDILIPLMVTESSVFGKDWYELLDIYLKVEVSCNGNIPARVLGSLLEPSSSYEIENQSAVEHWDLTLFPRQVSTFVYKLKKQNHNDKSAQQAKEHFLLRYQTLQKVEVGIKARLKARLEEQNLVQHLAHLWKNIRKEFLTSIDYNDYGLTETVHIKYFDAEVCESFLLHRDLKTKVELLDLIEEFLETNTSISQAEIRKNKTDIPERTLSFPLDVPTSRVLHTVELLLPSDTDMHINEPCECTLRISQSPYWASEDNTKNTLEYFVYEVDADYENWLMSGKRKLKFESKVGEVYEFPITLIALKTGQIPVPPVRVLSATHGAFSSTLYINSAQQILVRPKSRTATFFVEQQQRFVQQTAGVQPPYADDYQRNHLGAVIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQC8</accession>
    <name>A0A8H7PQC8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="2">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_003117</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQC8"/>
    <dbReference type="OrthoDB" id="1724632at2759"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000002">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000848">
        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6 14" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="15">
        <location>
            <begin position="213"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="241"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2177870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="537" mass="59414" checksum="D38594BBC510DB46" modified="2022-01-19" version="1">MSAAQDSVTQVNEMFDTVLILDFGSQYSHLITRRVRELGVYCELLPCTQKMADLHFKPKGIILSGSPYSVYDHDAPRVDPAVFDAGVPVLGICYGLQEMTNHMGGSVEACDHREYGHAMLTVTKHPNNPTMDKLFANLEGNVQVWMSHGDQVSKAAPGFHVIANTRTAPYAAVAHESKPLYGIQFHPEVTHTVCGQTLLKNFVIDICQCSDEWTMESFIDKEIARIRKIVGPTGRVVGAVSGGVDSTVAAKLMHEAIGDRFHAILVDNGVMRLNECQLVKKMLGDHMGINIKVSDAADLFLGKLKGVTDPETKRKIIGNTFIEVFEAEAALIDKEAGGEIEFLLQGTLYPDVIESISFKGPSATIKTHHNVGGLLEDMKLKLIEPLRELFKDEVRALGKLLGLDDELVWRHPFPGPGIAIRILGEVTKDQVAIARHADHIYIEEIKSNGYYRQISQAYAALLPVKAVGVMGDKRTYEQVIALRAVETKDFMTADIFASAEWFMCLKRISSRIINEVKGVNRVVYDISSKPPATIEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQJ6</accession>
    <name>A0A8H7PQJ6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_003509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQJ6"/>
    <dbReference type="OrthoDB" id="2405642at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2178256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="131" mass="15195" checksum="62D7CFBDC8FFA557" modified="2022-01-19" version="1">MHSLIHYYPQNMSVTFWQAPSMKRSATVHTELNLKQIEHPKKSPFPCERNDSMIKIVGPKEMSRRPSVKDLASDVYIAASAEKQIKLKKPQSEVTILVNAFIQYFKSVKERKQDMKKTWTTGQINTLNDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRB7</accession>
    <name>A0A8H7PRB7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha-soluble NSF attachment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_003337</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SNAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRB7"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2178084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="32525" checksum="F62AEE1D256981B5" modified="2022-01-19" version="1" fragment="single">MSETQARALCEQAKQQLGSWSFVWSSSNNLESAAELYIKAGNNFQLVSLWKDAGDAYSEAAKLYKRADHSNFEAAQAFEKAAKSYKKVSPKDALMAMVAAIALDKASGSFRIAARHSEEVAQLYEGQIDDQQKAYDYYEEAAHLYHMDNSPTLANRCTLKTADIAAILGQYDQAATKFEEVAYASVDDTLLKWSAKEYFFQAGLCHICTKDYIGARKYVEKYADAHVGFDTTREYDLLNKVIQSAEDDDVNAFTQYVFDYDKLSKLDNWKTTILLRIKRSLTDEELSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRE7</accession>
    <name>A0A8H7PRE7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRE7"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF0">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="74"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="224" mass="24756" checksum="C796C3078F9D1B4A" modified="2022-01-19" version="1">MLTEEPEFIVKYLNDLSSRSVRYGITHTPQVFQHKKLLKRQPPKKSSISQVEKPAVDESAPSSQSTTNAAQSTIKVTVKTLKPASQFEIFNLQPTDTIATLKDRISQQRSIPIKQQRLLVKGKVLNDTKPLAEYAISNDTVVHLMVKASPASPAKTADIPSPVESSVGAHGVSKEAESTLQTPELWKNLHNVLKESLGEQDAKVVISRFLQSEGWTGVTYDQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRN1</accession>
    <name>A0A8H7PRN1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Heat shock protein 78, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_001702</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRN1"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="140"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="532"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="9">
        <location>
            <begin position="703"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="801"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2178856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="838" mass="93510" checksum="4B2D5CD472981919" modified="2022-01-19" version="1">MWRMQRQLGTIARRSIHAAAHTKRSPVTLTSKTTLPTAALVPAGGRLVSATCGKVTVAYAISKRFYNGGGPQGGFRLQPQQEQQQEKPLEQYGIDLTAMAEKGKLETTRFGVQLKCKDQKFYEQTVKAMVFGTSNKKQPRADRVGKTAIAEGLAQRIVANEVPESIKNKRVVALDLGSLVAGAKYRGEFEDRLKGVLKEVIEADGKIILFIDEIHNLLGLGKSEGAMDAGNLLKPALARGQLRCAGATTIDEYRKYIMQDPALARRFQSVMVDEPSVADTISILRGLKERYEVHHGVRIADSALVSAAVHSHRYITDRFLPDKAIDLVDEACSKLRLQQESKPEALESLDRQIMTMQIELESLKKETDALSVDRRTKLENDLKQKQEESSKLSSRWQEERQKLEDIKRTKEELEQARVDLENAQRNGNFQKASELRYGVIPNLEKQLPKESAGDKDDNGSLVHERVTSDDIARVVAMMTGIPVQNLMRGEREKLLHMEEVLSERVVGQAPAIKAVSDAVRLSRAGLQNPSRPIASFLFLGPTGVGKTELCKSMAQFLFDTENAIIRVDMSEYMERFAVSRLIGSPPGYVGHEEGGELTEAVRRKPYSIILLDEMEKAHRDVSNLLLQVLDDGVLTDSKGRKIDFKNTIIIMTSNLGAEALVTDATHEGAVSDTTKSQVMNAVRQNFAPEFVNRIDEMVIFNRLSHQALRDIVFVRLKEVEERLSDRRIKLDVDKAATDWLGEYGYEPAYGARPLNRLIQKKLLNPLARLLIDGGIRTGETAKVTVVTTESGQHELEVRRNHAPGSVNHESEHELLEEGVTPIGEEEQAEADYKDKPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRZ1</accession>
    <name>A0A8H7PRZ1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Mitochondrial chaperone BCS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_001840</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRZ1"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000768">
        <property type="entry name" value="Probable mitochondrial chaperone bcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="15">
        <location>
            <begin position="53"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="253"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2178991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="50001" checksum="99D31963458F2A7A" modified="2022-01-19" version="1">MSEVTGNNWQSPNVDNTGSQQSSTVQQPQTQNESGLWATITSNPYFSAGFGLIGVGAGLTVLRQGINVGATLLRRRLLVTLEIPSKDKSYLWFLQWMSQQSARRTQHLAVETTYKQHDNGSVSTTFGLVPGPGNHFFKWRGVWLQVQRQRDGKMMDLTTGSPWETITLTTLSRDRDVFTQLLQEAQKLAIAKQEGKTVIYTSYGPEWRPFGMPRKRRMLESVILDNGVKDRIVEDVRAFIGSGKWYNDRGIPYRRGYLLYGPPGSGKSSFIQSLAGELEYNICILNLSERGLTDDRLNHLLSNVPERSIMLLEDIDAAFAKRKQTDQQGYQSMLTFSGLLNALDGVASAEERIVFMTTNHVDNLDPALVRPGRIDVKEFLGNASESQIRGMFLRFYEDQPELAEQFLQALKGKSVSTASLQGHFVYFKDKPLEALKHVDYLWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PS78</accession>
    <name>A0A8H7PS78_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable endonuclease LCL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Probable endonuclease lcl3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">INT43_002088</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LCL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PS78"/>
    <dbReference type="OrthoDB" id="430293at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000029">
        <property type="entry name" value="Probable endonuclease lcl3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="16">
        <location>
            <begin position="82"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2179238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="260" mass="29611" checksum="24C0CC3B535A7AEA" modified="2022-01-19" version="1">MRSDDDQPWWKTLFGQEEQKTTNVIEKTLQAIPQEMHDAPIGWSVAAAAIGIPASIGLFRLIVGKRYPTAAHIPPQVFQKQKKIKGKVVSVGDSDNFRVYHTPGIGWGWLRHVPTAKKDLKDQTIHIRLAGVDAPEGAHFGMPAQPYSAESKDFLSKMSLNKKVHLELYSRDRYERVVAMAHLRRWPFYWIRRNVSMEMLKAGMASIYTAKGAEYGDSLEKLKKAEARAKLLRRGIWSQKDYVDPSEHKKQYLRGGDSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSG2</accession>
    <name>A0A8H7PSG2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">60S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_001887</name>
        <name evidence="7" type="ORF">INT43_004388</name>
        <name evidence="6" type="ORF">INT43_009050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSG2"/>
    <dbReference type="OrthoDB" id="10267824at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023672">
        <property type="entry name" value="Ribosomal_uL2_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007180">
        <property type="entry name" value="PRK09612.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="5">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="4">
        <location>
            <begin position="95"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2171389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2174365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2179038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="27051" checksum="51A00A35A3FB8421" modified="2022-01-19" version="1">MGRVIRAQRKSGGIFKSITTHRKGAAKLRSLDYAERNGYVRGIVKEIIHDPGRGAPLAKVVFRDQYKYRLRTQTFIATEGMYTGQFIYCGKKASLSVGNVLPLSSMPEGTIVCNVEENSGDRGALARTSGNYATVIGHGDDGKTRIKLPSGAKKVVPSGSRAAIGIVAGGGRIDKPLLKAGRAFHKYKAKRNSWPRTRGVAMNPVDHPHGGGNHQHIGKASTIARDASAGQKVGLIAARRTGLLRGSKKLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PT48</accession>
    <name>A0A8H7PT48_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_001617</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PT48"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054295">
        <property type="entry name" value="CHS4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF41">
        <property type="entry name" value="CHITIN SYNTHASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="912"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="940"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="966"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase 4-like" evidence="12">
        <location>
            <begin position="352"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1102"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1159"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1102"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1194"/>
            <end position="1204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2178771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1210" mass="134715" checksum="ED73DCE82658FD44" modified="2022-01-19" version="1">MSNRPLPPQGGGYDQNMSAYRQQQQYQQHGQHYQQQQQQQQQQQPRPVRTQQPRTSRPPPANYNGTRASRDMLEAGNQPYRRVSLSRARSLSRPERQRPRPGMLRGESSEYRARPMGPAEQQRRMRQQMQQQQQYPQQPMAASKPLPQGPIVPPPPSKQPMVAKPKDKVVRGWWGWTARIVTCCFPNWFIKTCFRKPNALMQQAWREKLTLVYIILICCLALAFITVGLQRALCPAMRQTYPYSQEFEGHREKVYRENVTIYGQIYPFSEAQTFFKNNGLNLTNDYENTDLSGIFDGDISGACASYDANHPTSSLGGCRVNDPYGGWIQKNDSKCLSLKDLQQFYTSTASLSYDWVDLQPSGTDMLGKAPLLIYGDTVLNISKYLDANTQYFGATGDTILRNGMGNDASYSLMNNAQIKSAIPCLTARYQAGVISTENGGCIASGIIMNVMIAVIIAVVAIRYIMAVIFQWFIARSLVKPGGRSGFLSWRSKAGGNDDPANHIRAPTNLYNTGGSNNASVSSLSNTENGSPTASAVDLKPGIDIVSTKLYTILQVTCYSEGEESMRTTMDSLANTTYSNKHKVFMVIADGLITGSGESRSTPDIVIDMMDLDPTMADPKPCSYLAIADGEKQLNMAKVYAGHYKGVACLLIVKCGTPAEANTSKPGNRGKRDSQMILMAFFQRVLFNDRLSELDYEMFWKLTWLTKGVTPDKFETVLMVDADTKVLPDALTYMVAAMVNDITIMGLCGETRIANKRTSWVTAIQVFEYYISHHYAKAFESLFGGVTCLPGCFSMYRIKVPKNGSWVPILANPDIVLEYNQNVVTTLHEKNLLLLGEDRFLSTLMLRTFPKRQMMFVPQARCKTIVPDTFSVLLSQRRRWINSTVHNLMELVLVSDLCGIACLSMQFSIFIDLIGTVVLPAAIVLTIYVVVSVALSDNPNWQPIILLACILGLPAVLIVLTTRKLIYICWMMVYLLALPVWNLVLPAYSFWRFDDFSWGATRVVAGEKKDKGHGDADGKFDSSALVMKKWEEWEAERTGRKVINKSGSRNNLKTPDFNQSFDNGSFASLNAPPMFGGALGDRKMYGSSSSLLAAPSPYRPASIVSSRGNTPNASPRLGPYHIPPSNNPDMGRPNTPMMVPKRTSMAADVPYEMQSMNVRRPGGAAPPLPPHMRGHTNLISPQTLRREHSDDGDSTDGSSGSHVSHQLLRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PT90</accession>
    <name>A0A8H7PT90_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_003668</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PT90"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04154">
        <property type="entry name" value="Arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000393">
        <property type="entry name" value="ADP-ribosylation factor-like 2, arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045873">
        <property type="entry name" value="Arl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2179882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="184" mass="21065" checksum="419955F26D7E2056" modified="2022-01-19" version="1">MGLLTILKKNRQKEKEMRILMLGLDNAGKTTILKRINGEPIDTISPTLGFNIKTLQHGQYKLNIWDVGGQKSIRSYWRNYFEQTDALVWVVDSADRLRIDDCRKELLQLLQEERLAGATLLVFANKQDIPSALTHLEIKEALNLDAIKSHHWNIQSCSAVTGENLLKGMDWVVNDIASRIYMMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTB6</accession>
    <name>A0A8H7PTB6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
            <ecNumber evidence="5 13">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_003739</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTB6"/>
    <dbReference type="OrthoDB" id="10264771at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00445">
        <property type="entry name" value="alpha-phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01143">
        <property type="entry name" value="C2.B.3:_Phosphomannomutase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2179952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="253" mass="29227" checksum="A7B1B08950E923A8" modified="2022-01-19" version="1">MSTPSFSDRKKPDTICLFDVDGTLSPARLSMSDEMRALLQKLRKEVVIGFVGGSDFSKQYEQLGSTVLEDFDYCFSENGLTAYRLGKPLATQSFIKWIGDEEYNKLVNYILRYIADMDIPKKRGTFIEFRNGMINVSPIGRNCSQEERIEFNKLDDIKGYRTKFVQDLRANFSHLDLTFSIGGQISFDVFPTGWDKTYCLRHIKEEGFKNVHFFGDKTYQGGNDYEIYTHPEVIGHSVKDPQETMKQLNELFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTL7</accession>
    <name>A0A8H7PTL7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTL7"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19076">
        <property type="entry name" value="AKR_AKR13A_13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2179876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="334" mass="37108" checksum="09A3A910E795BE74" modified="2022-01-19" version="1">MSLPLTIPQREIGKTGVKISAIGYGAMSLAPGVYGSVDDENSIKLLEKALEVGCNFWDTADIYGQGHSEKIISKVLKNHRKEVFLATKFAIDRSNGQFRINGTPEYLKKACDASLQRLGTDYIDLYYSHRIDPNTPIEDTVGAMAELVKEGKVKYLGLSECSAETLRRAHKVHPITAVQVEYSPWTLDHENNDLIKTCRELGVSIVAYSPLGRGFLTGQLKSLDDLEADDWRRTNPRFQGENFAKNLELADKIKAIADKKGVTAGQISLSWLLAQGDDVFVIPGTRKEKYLLENLAAGSVQLSKEEMTEVRQIAESFDVSGERYNPEMMSSLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PU16</accession>
    <name>A0A8H7PU16_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PU16"/>
    <dbReference type="OrthoDB" id="2255243at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2180213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="120" mass="13637" checksum="6DE65AAA327EC4FA" modified="2022-01-19" version="1">MTIDQPQKISTNLEELTQSNSATTMNMNDLNKPCHPEWGVMREQAFHPLAFKHQRDLETHWEKGEVIPDFYFWQASLGGYCMADMTQNVVLSTEGTFVLVRRIVDGAAHPGRRKKKGGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PU64</accession>
    <name>A0A8H7PU64_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Choline/ethanolaminephosphotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003588</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PU64"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF77">
        <property type="entry name" value="CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2179805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="45961" checksum="0CF8E9D0DD97DBDA" modified="2022-01-19" version="1">MPASDAIPKAQLENLKLYRYSAVDKSFTSRFILRHYWNWAIELFPLWMATPGFERPNLITLTGLMFMVTNVIFAAIFVPGMDPEGGPRWVYFSFAIGLWLYSTFDNVDGKQARRTGTSSPLGELFDHGCDALNCSFAAVLQATTLGLGHSHMSVVLYGIAAIGFYLSTAEEYHTHVLYLGYINAPTEGVILSCIVFIATGVYGPSIWHLPLNQSSVKDWVPKFIPADTLVCDAIIWQIIALFLFTHAPVCLFAMYKACKAQNKPFLNALFTQSIPITIYTVSGYLWIMSPYSTLLEEKHFILFAITTGIVFGRIASKIILAHLLKADFPTFTVMLLPLMSGALIANLPVLFDVSPIFTAQTEYLYLCAYFAFAMIAYTHWAMVVIDSFCSFLGINCLTIPKAKRGSNGKPKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUA3</accession>
    <name>A0A8H7PUA3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_003812</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUA3"/>
    <dbReference type="OrthoDB" id="347018at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF31">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002401">
        <property type="entry name" value="GTP_bd_Obg/CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="5">
        <location>
            <begin position="58"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="280"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2180025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="467" mass="51480" checksum="8F4C3CC6F6E89F04" modified="2022-01-19" version="1">MSIMLRLQPRHSGQLSLSLKVSQRQSRHFHQTKWQFESEPTHTARDRSLDYKLRGKGRNFVDFVRVVARGGTGGDGCVSFHREKYVAKGPPNGGNGGRGGSVIFTASADETTLNHIPYLCAAKRGGPGLGASRHGLSGQDLIVKVPLGTIIREVDAPASAQARLDELSSEETKEEKLKKKWVHYPRSEQTTLAKGDFFRDAQKLIEEEERYARWKERQESESQIYIDMDVPDQSIVAAKGGVGGYGNPHFVTTENRSPKFATRGYDGKTRYLELELKTIADAGLVGLPNAGKSTFLSAVSNAHPKIAPYPFTTLNPYIGTVDFVDSFQLTVADIPGLIKGAHKNIGLGHAFLRHIERSKVLVYVIDLSVKEPWNDFSTLCNELEAYSKGLTKRPSIVIANKADVTAVAKDNFKKFEQIVLGEFESKGEKVAVIPVSAKYKKNIVKATTILRNMVEQEQSGAKPGIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVK0</accession>
    <name>A0A8H7PVK0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">P53-like transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_008679</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Su(H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVK0"/>
    <dbReference type="OrthoDB" id="5600360at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1450">
        <property type="entry name" value="LAG1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015350">
        <property type="entry name" value="Beta-trefoil_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036358">
        <property type="entry name" value="BTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040159">
        <property type="entry name" value="CLS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015351">
        <property type="entry name" value="RBP-J/Cbf11/Cbf12_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037095">
        <property type="entry name" value="RBP-J/Cbf11_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10665">
        <property type="entry name" value="RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09270">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09271">
        <property type="entry name" value="LAG1-DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01268">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01267">
        <property type="entry name" value="LAG1_DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110217">
        <property type="entry name" value="DNA-binding protein LAG-1 (CSL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RBP-J/Cbf11/Cbf12 DNA binding" evidence="8">
        <location>
            <begin position="185"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-trefoil DNA-binding" evidence="9">
        <location>
            <begin position="313"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="31"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2181097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="638" mass="68917" checksum="D4BB36E3398B4DD4" modified="2022-01-19" version="1">MSHVISDQVFGSSRRVRFIGMSPMDSLLSAIDKAHPSPSSQPTEPPMLPSLSSYLASSAPSSPSSTSSSNNDHQKSPTMSIKSLLDSPQQEAVAAAAGLTKTEANVASLLANPNSYLPPSPRMETIGMKRRQWSDRPYESQDDRAAKIRRCIREQISGQHGKYSILDAPPSPPHHPAMNQSRMVTITCLHAAVAQKSYGSEKRFLCPPPVVSIKAPARSEKSMERPSVSMSVICPEMGPDRSVGQRAILDETMTGSFKYLHVTGTAKAKHFQLKVQISHPGHANEPYATFDTDNINIISKPSKKTAKARNVSSCILSNTPVSLFNRINSQTVRTKYMTVERSQLCAKNSSWSAFSITVVRVPASATSTSSRTPGCVPVAYGAEIILTDLETGVSSEPLIIRKVEKGRIAQQAGGPVSQMQKVALQRVSSTAPGATPSYLSAAGAFTDAQPDQASNNANAFLGYESSRIVHTEATSPEGPTPITTEEVDDYLCWTIVGIAKFQHTYFESSPAQEGTQCNVSPFPMLTSGVYKATTHSLEICTKDVAEGTEIWLGPHGPLRTRCLQSAGSRAQFSVELPSTQDVIVTNHDLLTPDTHGSRSLELPIFFVRADGVVYHSGRAVRCRVEENGDAGRWCLTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PW08</accession>
    <name>A0A8H7PW08_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_008920</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PW08"/>
    <dbReference type="OrthoDB" id="9805536at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004039">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="63"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="187"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="417"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2181337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="547" mass="59195" checksum="ED1E69565E327C9B" modified="2022-01-19" version="1">MLRTVARSALAASVRRAAAPAARLNLGAASMAVRNYASAKPQTSEVSSILEQRILGASGDVDIQETGRVLSIGDGIARVYGLKNCQAEEMVEFSSGLKGMALNLEPDNVGIVVFGNDRLIKEGDTVKRTGAIVDVPVGPGLLGRVVDALGNPIDGKGPLDSIGRTRVQVKAPGILPRHSVREPMQTGIKSVDSMVPIGRGQRELIIGDRQTGKTAVALDTILNQKNWNFGSDEAKKLYCVYVAVGQKRSTVAQLVTTLENAGAMKYSIIVAATASEAAPLQYLAPFSGAAIGEWFRDNGRHSLIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNKDFGYGSMTALPIIETQGGDVSAYIPTNVISITDGQIFLEAELFFKGIRPAINVGLSVSRVGSAAQTKAMKQVAGSLKLFLAQYREVAAFAQFGSDLDASTQFLLNRGARLTELLKQPQYSPLSIESQVPIVFAGVNGYLDKLPVGKIVEWEKDFVQYVKANHNDVLEEIRNKGVLSKELENKLREVCDAHVKSFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXS1</accession>
    <name>A0A8H7PXS1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="5">HMG-CoA synthase</shortName>
            <ecNumber evidence="5">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_007164</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="5"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXS1"/>
    <dbReference type="OrthoDB" id="1269963at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="7">
        <location>
            <begin position="182"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2182237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="451" mass="50475" checksum="7C74BD4EE1F08E9E" modified="2022-01-19" version="1">MPRNFDHYPKNVGILGMEMYFPSRCVDQTEMEAFDGVSAGKYTIGLGQQKMAFIDDREDIQSICLTAVQKLMETYKISYNDIGRLEVGTETIIDKSKAVKTVLMTLFAEHGNTEIEGIDTTNACYGGANAFFNAVNWVESSSWDGRYAIVVAGDLALYASGAARPTSGAGVVAVLIGENAPIVVERGLRSTHMEHAYDFYKPDMHSEYPIVDGKFSNTCYIRAFDSCYNRYMNRLAAQSGNEKVSMEDVDYVVCHSPYAKLVNKSFARAAYNDFVRDPENPKFADFKQLAEISYADSLENRDIEKAFMGYTKESYNTKIGPAAFVPKHIGNMYAGAVWAGMASLISEVPSEQLQNKRVLLYAYGSGLAASMISFKIVGNTDDIKAKLNLRERLSKRTASKPEEFAEAMAIREKTHNVKDYNPIGSLDHIASGVYYIDTIDDKWRRFYKRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PY45</accession>
    <name>A0A8H7PY45_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PY45"/>
    <dbReference type="OrthoDB" id="2281185at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2182261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="108" mass="12076" checksum="6F32458342E7653B" modified="2022-01-19" version="1">MDPGYKLLQKLKQVPNLVNEDPSIITPLILTCCSSIQTNTSFMDMPWSDFSKLLAQQNRRSSSSTSSNASSNEVSSEEYDEQDINDDTLGNWDAQTGYQEGGKIVRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYX0</accession>
    <name>A0A8H7PYX0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Long-chain-alcohol oxidase</fullName>
            <ecNumber evidence="5 12">1.1.3.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_007192</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Long-chain fatty alcohol oxidase involved in the omega-oxidation pathway of lipid degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:22756"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="EC" id="1.1.3.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.20" evidence="5 12"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYX0"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046577">
        <property type="term" value="F:long-chain-alcohol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012400">
        <property type="entry name" value="Long_Oxdase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056:SF12">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028937">
        <property type="entry name" value="Lg_Ch_AO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="14">
        <location>
            <begin position="269"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="15">
        <location>
            <begin position="560"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR028937-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2182265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="725" mass="80348" checksum="813380D90D4A2DED" modified="2022-01-19" version="1">MIYGQCTHWLALPGFLFHHSPYIMTSVFPAFNPTNEQRETMLALMDTILCPLTDAETEALIQTAKQSKGNKLSREDIVAFAQAKASDFDIVSFFIDTIVRAAAVSKLNDVTLALNLLGSRAGSLALTGHFTPYKDLTREQRIEVMRKWSNSSLLMLRSIHKLFYQLTSSNIFKQPNNPLHKALGYPGPDPHMHGEKHSSKIKEHYEFINVPEGVTEVTFDAVIVGTGAGGGPVAAKLAKAGKKILVVEKAKYLHETQFQLDEVHGFKSFYERETIFSNLDGCMNIYAGSAFGGGTTINWCASLKPQHFVREEWAKQGLSHFVSNRFTEHLDEVYQRIGATTAHIKHNESNKILIDGCKRLGFPIEDIPQNVGECPHECGWCFLGCRYSEKNGSMNTWLRDARDNGAQFVEQCYVDRVLIKKGKAVGIEATIAGNKNRKLIVHSKQVIVSGGSLNTPGILRRSGLKNKNIGKHLRMHPCHVVFGVFPDREINTFQGSIMTSLSNIAENHDGSFYGAKLEVPVLHPSSFSAVLPWKDPLDYKQRLVRYPNTSPVLILSRDKTSEGTITYDENNQVIVDYSVTKRDKQSIMYAVGKALDVLVAAGATELFTCQAGVDTFMFAKGEDRYGQIDNKRYIAWKEQVMNYGLLEAGSGIFNAHQMGSCRMGVSPKSSVVKPGGETWEVKDLYVADASVFPTASGVNPMVTTEACALYVADTILQSNSINAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZH9</accession>
    <name>A0A8H7PZH9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZH9"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="94" mass="10666" checksum="AD2EB8485493F6FD" modified="2022-01-19" version="1">MSGLFSFDDDDHPALRQRTMSDECHYEDSDTTTDDEFTEEALAKSYSHQCELDNTVYEIPLDEDFAASNAQEILGSRKVTKDDFEHLKVIGRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZJ7</accession>
    <name>A0A8H7PZJ7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_007244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZJ7"/>
    <dbReference type="OrthoDB" id="2278238at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2182314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="153" mass="17047" checksum="EBDEB702B08DE49D" modified="2022-01-19" version="1">MSCQACSGCYTGGGCSTKRSTSDRKGSTKLETLITKAQTTNSNESTDHHIITTIVSIISNDVYASQMALFQMYESLPVNQFLEIIRSCHDHQLAGPHLAWLWEYTKGDAQAVYRLLVDGATEDEKNQLWDHLDDHVELHQAFGGADVVNKTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZJ9</accession>
    <name>A0A8H7PZJ9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Splicing factor subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SF3B5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZJ9"/>
    <dbReference type="OrthoDB" id="274726at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017089">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037010">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="10270" checksum="ED4909FECD22B374" modified="2022-01-19" version="1" fragment="single">DRLNINSQLEHLQSKYVGTGHADTIKHEWLVNQHRDSNAAFVGHHSMLSYFAVAENESVARVKHNLVQVRHSSLMKMVQPCGPPVEREEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZV6</accession>
    <name>A0A8H7PZV6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein RAD51 homolog 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_006805</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZV6"/>
    <dbReference type="OrthoDB" id="5957327at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000707">
        <property type="term" value="P:meiotic DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052093">
        <property type="entry name" value="HR_Repair_Mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2183794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="296" mass="33593" checksum="DBFFAEE5F3624864" modified="2022-01-19" version="1">MMLRPTTVLLMMRPIRHQIADTQGGFSAQRAQEIAQSMVQQMKAQAGEGQDHILTAQDLLSNIHFFRIHTYHELLALITSLPDIIESYPKIRAIIIDTISFHLRTNIRDLLTKSKIIKTILEHLRKLASSNQVAIVLMNQMTTFKDGKTIIPALGQRWSQHIHCRIQLSEDERGRYAVRIKPSSNLSLHRSFTIQSGGIRNEVGNIDIIREHDNTSISLIKLSSEIADVELADSSVLTETSILNEDAEPLSLFENDILQEATQTYAGRKRHFDDIEPADQEYSDADVLCFASQDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q046</accession>
    <name>A0A8H7Q046_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein MGR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_006459</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q046"/>
    <dbReference type="OrthoDB" id="5409308at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018450">
        <property type="entry name" value="Romo1/Mgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525:SF1">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10247">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01378">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2183453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="10592" checksum="D1896FCAA091C874" modified="2022-01-19" version="1">MEPTTFDKMKMGAMMGGTVGLCVGLVFGTVNIMRFGTGQRGAISMLGSYMAGSAASFGFFMSIGSVIRTEEQQRIMWPSQSHLGARPNIYVASKKEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q070</accession>
    <name>A0A8H7Q070_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Superoxide dismutase</fullName>
            <ecNumber evidence="7">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_006680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="7"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q070"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000004">
        <property type="entry name" value="Superoxide dismutase [Fe]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="8">
        <location>
            <begin position="29"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="9">
        <location>
            <begin position="118"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2183672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="223" mass="24848" checksum="23559D707DBE4FEF" modified="2022-01-19" version="1">MLSIAARSIRSSGFKSVAAPLTAVRTKVSLPDLPYGYKALEPYINGDIMEIHHSKHHQTYVNNYNAAEEKLSSAFQANDLTQQLTLQNALKFNGGGHINHSLFWQNLAPKDEGGGELPKGSLLSAIQKEWGSFDNFVSQFNTAAAGVQGKLRLGMGYNKSAKRLEIASTQNQDPLLNLVPLLGVDVWEHAYYLQYKNARPEYLKAIWEVINWKTVAERFAKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q130</accession>
    <name>A0A8H7Q130_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_006381</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q130"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000006">
        <property type="entry name" value="DUF21 and CBS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="459"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="568"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="744"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="777"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="808"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="849"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="904"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="931"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="970"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="17">
        <location>
            <begin position="841"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="16">
        <location>
            <begin position="1047"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="16">
        <location>
            <begin position="1113"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2183375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1275" mass="141294" checksum="2852F88DBAE55187" modified="2022-01-19" version="1">MYRYPTDSSVAQSPPSMYQMESRRRPSDLDYDYSSPVGYPETTPYVPFNAVPTPPIHDNTGASSGIHYGPLGTSANFGPDPPYHHALQPQHSELGLAPARQLRRYNTKKRVQLVRGNLVLDCPCPTRLLQAVPRKDAKEFTHMRYTAATCDPSEFAKDYTLRQALLGRSTELFIAVTMYNGVNGWQKVTVCVIADGRTKIHPRTLAVLGAMGVYQEGIAKNQVQDKEVTAHIYEYTTQLSVDSNLKFKGADKDIVPTQIIFCLKEKNAKKINSHRWFFQAFGPIIQPNICVLLDVGTRPGNTSIYHLWKTFDVNSNVAGACGEIRAMTGPAGVHLLNPLVAAQNFEYKISNILDKPLESVFGYISVLPGAFSAYRYIALQNDMNGHGPLEKYFLGETLHGGIKSGIFEANMYLAEDRILCYELIAKKDQAWVLKYVSSAYGETDVPNSVPEFISQRRRWLNGSFFAGIYALWHWGKIFQTAHSTGRKFALLIENIYLTINLLFSWFAIGQFFLSFFILTQSLTTVEPPPFSPTAANIVHQILTYVYLILIIVLFLIAMGNRPQGSKAAYIACFVFFALLMVYIMFCSIWLAYVGVQSALSGSAGSLLSNGAFRDIVVSVSATYALYFVASILFLDPWHMITSFGQYIFLMPSYINVLNVYAFCNTHDVSWGTKAQTGVATDLGVVATAQNQETVEVHLPTEQKDINALYEETCLELQKKRAEEKSHRDARTKQEDYYRAFRTRLVVCWIISNLVLAIVVANATILQWLGDFNTRTNAYFAFILWSVAVLAAFRFLGSLTYRITGLFSAASRLTLARLSIVFGTSILTVTRGSPINIMEDENVNVGSAEFWTRFGVIIGLVLMGGLTLGLMGLDETNLQVLMVSGTEAEKKNAHKVYKLLDRGKHWVLVTLLLSNVIVNETLPIILDSVFGGGWQAVVISTALIVIFGEVIPQSICVRHGLAIGAKTSEMVLGLMYIMWPIAYPTAMLLDYFLGESHGTVYKKAGLKTLVSLHKAADENGDVDALTDDEVTIIGAVLDLRAKPVSKIMTPIADCFTLSLDAILDEKVMDQIVSAGYSRIPVHSPGSKTNFVGMLLVKQLIKYDPEDAEPVSSFHISNLPETGPDTSCLDILNFFQEGRSHMALVSNDPGGDTGVLGVITLEDVIEELIGEEIIDETDVYVDVHQKIKVVRRTANKTNIRLFPFLASRRRMSKDLRNDKIVASKNLKRNDSTSKPGEGQEIETRIKGYGAVISGSLETESATFGSAGESQPLINNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2B7</accession>
    <name>A0A8H7Q2B7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dipeptidase</fullName>
            <ecNumber evidence="7">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_006765</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="7"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2B7"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000180">
        <property type="entry name" value="Dipep_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00869">
        <property type="entry name" value="RENAL_DIPEPTIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034527673" description="Dipeptidase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2183754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="804" mass="88739" checksum="4F9B067C820C07F2" modified="2022-01-19" version="1">MAPSLIFSGLLYTAMFGIARAAPDDECSSHPPADYNMSMHIAAVFIILVASGLGAFIPVLAKVLPYFKVPGKIITLGKFAGSGIILATGFIHMLPSAMDNLTSPCLPSVWNTGYPAFATLFAMLAALAMQLIEHLAAEHAHKRQQANAKHDEQAFPDIENVKEQQDAMSKSNEKTISKSQETLIESRPCQTPVNVNDAAAVMALSHIHSHHTHTHEGSKDHYPHSHHHHHAHAASHGHDHGDILMLAGTKDLSTFILEIGITFHSVIIGIALGVSPGDEFIGLLIALCFHQFFEGFALGARLVELQFGTYRHAFIMAIVFALTTPIGCVIGIAISQSYDANSVSALLTQGIFDSVSAGILIYMAFVNLIATEMVHDEGFKKLDKTTKWSYFAAMWFGVAIMSVIVRRYLSPSYIFVDMRAFIAGAIALLAYAVSAQDQIPISHSESYIARANKLLEQQPIIDTHNDWPIFLKFYHGGKIANIDLENMNNSHTDIKRLREGHVGGQFWSIYYPCEDKDANQVKEAEELMDLVQRITKRYPETFQLANSVDEYNEAIKNGRIASMFGVEGGQHIDSSMAVLRQFYESGVRYMTLTHNCHTPWAESQSPATEYPFPPGTGLTNFGRKIVKEMNRLGMFVDISHVAHATMHAVLDVTEAPVLFSHTSSHALCPIERNVPDTVLRRLNETDGVVMVNFYSRFVECDSSKRATLSQVADHIEHIAAIAGRDKVGLGSDFNGIDVTPVGLEDVSKYPDLIAELLRRGWSDEDVKGVAGGNLLRIWRGLEAARDKLVDRFPDESYIEDEDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2N4</accession>
    <name>A0A8H7Q2N4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_000920</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Preautophagosomal structure membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Vacuole membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="6">During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATG11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447953at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903599">
        <property type="term" value="P:positive regulation of autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040040">
        <property type="entry name" value="ATG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019460">
        <property type="entry name" value="Atg11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222:SF1">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10377">
        <property type="entry name" value="ATG11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="9">
        <location>
            <begin position="142"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy-related protein 11 C-terminal" evidence="10">
        <location>
            <begin position="1173"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="580"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="798"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1303"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1379"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1433"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="694"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="829"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="937"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1060"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="580"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="799"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1303"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1322"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1338"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1453"/>
            <end position="1463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2185007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1479" mass="168702" checksum="5423652362C45394" modified="2022-01-19" version="1">MLLTYSFCIKLRLDGLRRLLERYTGVPASAQILMTSFGTQVKQDMVKDVVQARGKEEYILIIYDRQYLDASHDEVMTLIDVEMPKFQPSPAVIDGTSALRSLRAKCSATKSNTSKHFEFYYSLFQEFESYTEAALEVIKIHTATANNIVAEQKAQSMALNVALTNLEAHVRVSSNKFKGFQTVANRDFSQLLIAVENVSRDIEVLQRTQVHPLIRDALSQERNVKFLSELLDEQTTLKTRSSIANTRDILVEETQELASLIDDIQQGEVALRQQSLSDFDLQALDTRLVDVREVCEKAIFLRDKIERDFARVHDKIQDIMPLTSGSRQFSDRLSKSPDRQQLFQPSPPPTLPSHAKKTVEAFDHLAEIHVKDYLPKIAEYEQVIRNHLSMLIKSKRRAMEGFLRQMNVISHLQSEIAAVSPRIDAVDKEMKGLKKQAGKDGLQKPRLIILAYGALIIEIVRRKEYANILLENASVIADLFGRYRMSEQNRRDYYRTEYARLIPFHIEGTNESAIVILCFLHFVNFPPFAAMDDSASYCEVSASNIRDRGPNLTRDDANQFLMLIKEYLSNNDIQSAMGSPLEQLSSRVQSPYNQQTSPLNNSITLRGNSPSMSRNPSQSRAFDSKPEKVVNQLMSMNDDLNTLRQQFLEAVDKSYFQDQKFPNTNGSNRRISAPIMPTSRVSSPVIVSDSEALLVQKTRALDIADEKLKTYEDRIQMLEEALQKAHQPTRSNPLGESVLLGKAKWNEEGTAIVQQQHSGSSSFYSVADDDWTKKQIGELYVKLQEADKKNSDLERQLLRQRSSSSSMSSQRSDASHSWDREKVEWEKYREYNEHEKEDLRMQIQNLEQLLEEERQTFEENRKSLLKEAQIRDNLADIRIAGAEGDWKTRIEELEENLSKQQEEADQMSVNYEKEIKLLKESHIQEISAVQHETQSKVQELKGAHDKISQLVRQLEELQEEMKADKVASKEQLRQMQEEMDNSEQARDEIKQRLSQARDMVAAAEEDWMAKNTALEKIIDDQTVLKGIVHNIASKLISEQVTELDQEATFLQLLDIIDKSLDTKLEELEALRLTFNELQSNQQQLEEDLDDLSEKHTALRKLCSQMAMKLVDVRLSVFGEITNQLQLPVDENEASNLVRRLSFESNIDSSAAFAQWSETLHSINSVDLSKFVFKVRKKVKDAHDLTRRWQKEYKDLKEKYGRTAAESYEKIAFRNFKVGDVALFLPTRNSTGKPWAAFNINAPHFFLKPTDNIISQMSTREWIVARITSITENVVDYQIPSSNPYGLSDGFKFYQLEVENWRNSHHRKTHRSQVGKDKDKDAQTSSSSKSPTMQSSTTIVAPSQTEQNTQMASSKELSYGRRYTLPYVNGKDTGLAALADETISPPPTSPGISTRRMSFERQPTVTSPVFRRPGFTSHNTVSGYLPMTSSSSGIISNTTASNHPESSSLTLDADYQRNPDDKLDLPSSIDQSSLIWAAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2P0</accession>
    <name>A0A8H7Q2P0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7137 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_000634</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2P0"/>
    <dbReference type="OrthoDB" id="2435509at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055561">
        <property type="entry name" value="DUF7137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028:SF1">
        <property type="entry name" value="YALI0E30657P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23585">
        <property type="entry name" value="DUF7137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7137" evidence="3">
        <location>
            <begin position="83"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2184721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="250" mass="25708" checksum="7BA9646229C02E37" modified="2022-01-19" version="1">MDRYLQFLLLHFAAVNPPQQSSPVASAASSSIAPATSSGGGSVMPTAASSINTAPQSSAGIQPSASGNSLAALPTSATFPASMQPGYLTWSTPTPNSSAPPLYKIGPTTNVTMVWGFGPNLKVRPENLTLAYVAGANTQTITVLDGMATSAVWQLGSVPEATPLMNGLYKILLMDQRGPTPYPSPGWFYPGSTLTVGMYSPQAYANWTATGACPTCMNSAGSSIFTGMGPWLLTLGVAGVSSAVFLYSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3Z8</accession>
    <name>A0A8H7Q3Z8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_000801</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3Z8"/>
    <dbReference type="OrthoDB" id="3361892at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032931">
        <property type="term" value="F:histone H3K56 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016849">
        <property type="entry name" value="Rtt109"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF2">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE RTT109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08214">
        <property type="entry name" value="HAT_KAT11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01250">
        <property type="entry name" value="KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51728">
        <property type="entry name" value="RTT109_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="235"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2184888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="449" mass="49848" checksum="F5219CC3D4642615" modified="2022-01-19" version="1">MSAEIQNALIQALNKLPSNNGSYVVYHFVTKPVLCKYPIELNLSGMFSQSSKVHRLIIVAHERSNGKPALVCGLEAMEYKMKTTDAAPSIAYVSKIDTTGYKAPAPITAILIESYLSSLKECNIHIFARAQPQYLFPESVKNASKRAQSDRGLIAWWLRAISNTPFSSTIDAWWNVPGVDDEDSAKREIRVTHKIESQQIRWHYGYPYDDTADAKSVIPNFPDDAKARLLKSYAGYDKKDDSEEEEEEEEEDVDNVEDESDNEGQEGVTKSKEVTSADSQNTSSTPEDIPSDDEGAVEDDESKNEFKDIVDNNDPQSMTVREFWQLLSIGEECGAGKLTGFFIIKCGSVTSADIATVPSPTTITSEQFTVIWNKLMSLDFSSEESNVKSTLSINSSIAESIQETSYTPTKVNPTGQPVEKTLKRPLQEVKQPIPAVNVLGGSFIKRKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4K4</accession>
    <name>A0A8H7Q4K4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like 1-activating enzyme E1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002827</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4K4"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01492">
        <property type="entry name" value="Aos1_SUMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="7">
        <location>
            <begin position="17"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2186389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="338" mass="38192" checksum="D89CD2D6EC6531ED" modified="2022-01-19" version="1">MAGKDNNTITEDEAALYDRQIRLWGLESQQRIRNANILIVGVKGLGNEICKNLVLTGIGSLTVLDHEPVTMEDLGAQFFLTEADIGKYATEAASIQIQALNPRVTLKVDTENIEKKDDQFFEQFNIVCVTNASQSILIRLDGICRNQNIPFYAADTFGMFGYFFCDLHSHQYLQIRKEEPTAKNEAPKEISEPRIEEYCTLVQSLERNWSDIKKSQLKKRVSRTYPMALLRYQFQEVHNRLPSPADEAELCQLRDQYLMQLGFADLSFLDNSMIEILAQTAATELSPVCAIVGGILAQEIIKVLSGKELPVQNWFLYDGISGSGLIHHIEKGKPMILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4M0</accession>
    <name>A0A8H7Q4M0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4M0"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31964">
        <property type="entry name" value="ADENINE NUCLEOTIDE ALPHA HYDROLASES-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31964:SF113">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="15"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2185726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="167" mass="19305" checksum="C66D7A95E934D8C7" modified="2022-01-19" version="1" fragment="single">MDTSKIPRLPSKSPRHIIIAIDPQSREADHTIQWALDNLLDSNRDQVDLVFALVLDADFSTDNVADIPAVYDYQYLMEIEQQIEERTTTAMKQYEKQLADQNIRVHMKVYRTIGSESRNVLVEYTNSSKADILIMGSRNLSAWKRFFWGSFSDYVQAHVHCPVIIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4Q4</accession>
    <name>A0A8H7Q4Q4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_002510</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the creA/MIG C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4Q4"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000089">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000152">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF1">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="156"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2186072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="292" mass="33206" checksum="2D3413420BED133E" modified="2022-01-19" version="1">MEKQRSYQCPICQKAFFRLEHQTRHIRTHTGEKPHQCTHPGCEKRFSRSDELTRHVRIHTEPARKRQHRSNMVKRHTSPGSSAIFKQINIMATPQSFDRHQQQQQQQCSVIRFNDDVNMGEHVPSSSWKLQPCPVEGCFKSFWRLGQLARHVRTHQQVSPRANESILPSPALTPSSSPVMSHAKWNPRSPPHSNISSPDLESDSIVTPENSPLLRPFQKLPAMECQVAEPVYSRGNGGFSRSSSPPLAHIMNEREPAARKLPTPAMFDRPTMPLTTEPTCRLPSIKSLLNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5E7</accession>
    <name>A0A8H7Q5E7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5E7"/>
    <dbReference type="OrthoDB" id="2367685at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2186432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="241" mass="25541" checksum="B91E019B19091209" modified="2022-01-19" version="1">MQDYKQSPQSSQSSQSLPPPPPLPSGWIAQWDETHNRYFYANTVTGQTQWELPTEPATPGGGEANAYQGAPPQYSQVDPKQSPSSSSDRGLGSFMSSAMGGGRPQNGYGNQYQNGYGNQYQSGYGGGYPNNGGYSNSGNSGFPGGGSMGGMIAGSLMGLVAGRVLGNDHRHQRPGLIGSFMAPALPNGGFMGRKLKIVHNMAIHMATATIRIMDVTVTINIMDIITTTTTIITDGRNPFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5U7</accession>
    <name>A0A8H7Q5U7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phospholipase A-2-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5U7"/>
    <dbReference type="OrthoDB" id="10265988at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000236">
        <property type="entry name" value="Polyubiquitin binding protein (Doa1/Ufd3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="164"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="203"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="243"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="6">
        <location>
            <begin position="379"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="7">
        <location>
            <begin position="523"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2185818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="802" mass="88388" checksum="A6BA07C06719A3E1" modified="2022-01-19" version="1">MTVTRPSSAVTTRSFLYSSMSETGSQYKLECSLHGHELDVRAVVALSNDLVVSAARDKTVRSWNRTQANDFEQQHTYLGHSHYVNALASLPPSPEHPKGLIVSSGSDKVINVYDVDRSDDPVYTLVGHTENVCSLAVTASGDIISGSWDKLAIVWKDFQQAYVLKGHEAAVWSVLSVDNDRVLTASADKTIKLWTNGKLTQTFSGHTDVVRDLAMIPGLGFVSCSNDSSLRIWSLSGETLMELSGHTSFVYSVSVLSTGEMVSSGEDRSVRIWKDGQCIQTIHQPCISVWCVNVLPNDDIIVGGSDGIVRLFTRSQERFADQETLKQFDDLVASHAIPSNQVGDVKKDDLPGTEALHVPGRKEGQVLMVRNGDVVEAHQWSSATGTWTKVGEVVDAVGSNRKQVYNGQEYDYVFDIDIGAGPDGMLKLPFNVTENPYDAAQKFIWKHELSQDFLDQIADFIIKNAKGVEIGMSNSAQYVDPYTGAARYTPETRAADANATYLDPFTGSSSYSTNSAAMAAEPKVLPQKSPLLFKQASLSAIHKKILSTNAEIDAALSQEDIEKLNEGVHYLQNPVANVSDDKHRGSISTILKIITTWPVELRFPGLDLIRLYALYQPSALLSSITDGDLESFFRTWANLNQLSQYTGGQKATDKTLETNYMLAVRTYANLFGTDIGSDYIKRQKQAIISLLLTDGSWKSFQTKNFRLALATLFLNFSVHLSKTSTDEEDELLLVQNIIEYLKEELDVENVYRAMVAVGTLLSQSSNAKEAAVVFDGPVVLQNVTRQQSDVRIRKVADEISKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q664</accession>
    <name>A0A8H7Q664_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_002216</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q664"/>
    <dbReference type="OrthoDB" id="449052at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF128">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="18"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="180"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2185779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="312" mass="35121" checksum="B90BC7C4CCB8AC7C" modified="2022-01-19" version="1">MSKPITTITAKELGLHGVKRYLIVVQPNMLIRDALDVMSRNHITSLPIYSHSSTQITSIVNLFDILIHLVKDSKTVEFDEEEFRRLSEPLENVLGLDGDMESYRLHKSYDDDQLIDTLRAFASGIHRSIVIDPSDKAAPWLLSQTDILRYAQTNPECLTTLGIDLEMKIENLFDHRTPPKLPTLITASPTDMTIEVYKKMGKNKIAAMPIIDEGKIISDISIEDLPSADLTKPNHLSLPCYEFVKGLNKKTSLVLSKDETLRELLNGLINSHVHRAWISNSSNKGEVESVISMSDIISYICHCHQAHPQNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6B4</accession>
    <name>A0A8H7Q6B4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_002793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6B4"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2186355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="224" mass="24315" checksum="7A4B4ECC9067F3F4" modified="2022-01-19" version="1">MSAIEVQAKCAIFDMDGTLIDTTRAITDHWEEYASKHGLDANEIMKMSHGRPMLETMKHWTPEHATPEISAKYERRLALNANGVALAAGSAKLIESIPRDRFGMFTGAKTFTAEQRLSQCEIEKPASFVTADMISRGKPDPEGWVLAAKNLGYEAKDCVAFEDSTVGVQAAKAAGMYTVACLSTNTFNNLKAAGADYIVKDLSEVNAEIIESGNLKITISSSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q779</accession>
    <name>A0A8H7Q779_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_002832</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q779"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000211">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="7"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2186394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="460" mass="50121" checksum="68C66F934477D9B8" modified="2022-01-19" version="1" fragment="single">ETMGKEKTHVNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFETPKYHVTVIDAPGHRDFIKNMITGTSQADCGILIIAAGTGEFEAGISKDGQTREHALLAFTLGVRQLIVAINKMDTTKWSGDRYEEIVKEVSSFIKKIGFNPKSVPFVPISGWHGDNMLEESTNMPWFKGWTKETKAGSKAGKTLLEAIDAIDPPQRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGIIKAGMVVNFAPANVTTEVKSVEMHHEQLVEGVPGDNVGFNVKNVSVKDIRRGNVCSDSKNDPAKEAGSFTAQVIVLNHPGQIGAGYAPVLDCHTAHIACKFAELIEKIDRRSGKKLEDNPKFVKSGDSAIVKMVPSKPMCVEAYTDYPPLGRFAVRDMRQTVAVGVIKAVEKVDKSGKVTKAAAKASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U6Y5</accession>
    <name>A0A8H7U6Y5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U6Y5"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="133" mass="15295" checksum="263ECF2590129EAF" modified="2022-01-19" version="1">MTKNNIELGLGIIKNTILDNLEKSFKKLDLGKEVDALILEVIENEKAADEYPKKTKKKVINLDRPKREIAPENQCQRIMKNGQRCHGIKTNNITKSCWGHMTATEKEEHRMSKNKPSGKKHSVQRQLEDEADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U722</accession>
    <name>A0A8H7U722_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Essential protein Yae1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U722"/>
    <dbReference type="OrthoDB" id="48036at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052436">
        <property type="entry name" value="LTO1_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532">
        <property type="entry name" value="GEO13458P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532:SF1">
        <property type="entry name" value="ORAL CANCER OVEREXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2172821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="123" mass="13858" checksum="379CA5537DD4CA85" modified="2022-01-19" version="1">MYLRFQELGHEDGMRDGKRSGVIEGRVLGCEKGFEMSNEVGYYMGCAALWTQLVSANPKAFSSRAIKQIQTLQSTVDQFPDANEDQTDTFALLDKMRAKFRVVTSVLKVEQKFSNTQPTGMSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U771</accession>
    <name>A0A8H7U771_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U771"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2173346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="211" mass="22708" checksum="46DF2EE97DDA8C34" modified="2022-01-19" version="1">MQTLQLLWWRDTSIKTTTEYSSFLRTLQPVGSTQLPPLNWQPVGTVQWSGALPGSIIAPGTFAIGGTSPSPVVSGFAALSSGSPVSIPTLAGGQAADLDFASFSLLPLLFLFFVAGVFAGAHCPFPLFRPRSPASQDRNKMTSPAEAAPNVAFPPAASPSAFLSSSRLHYYSPTRPPLPRPKSQKDFPRSNTVPRILPIHLTDMRHKFTFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7E9</accession>
    <name>A0A8H7U7E9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_009026</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7E9"/>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000145">
        <property type="entry name" value="Putative RNP domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF64">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="103"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="227"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2171365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="593" mass="65593" checksum="C4BB1DBE3AEC9273" modified="2022-01-19" version="1">MSEVRLGGDISDSVSEMTDPENTQSSKADNSVDTAFRMSYKADFVLEEQEPSASNGSKQVEKYRSSEADTATCANTNIRADNNGALEERCMDNSANNVKVHARQLFIGNLPFRVRWQDLKDMFKKAGDVVRADVAIGYDNRSKGHGTVLFTNIQGAQHAVDLFHNHTWQGRVLEVREDRGYIDREAHGGGLTKAPSTKTIFPAPGVHLNPLYINHAQTAPPHTTGRNQLFVGNIPFSCQWQDLKDLFRNAGNILRADIAQGQDGRSRGFGTVLYATIEDAQNAVEMYDGYEFHGRQLRVHFDKFAPVPSSLLPGQLLSSVHESQFKHPSQHQPPSYQSIMPITSQALPGVLSHQSQLQSRQYYPNSHHVGNMSIPPQYQLPNAILHNPHSMIQSDRIAGASPSYNQMDHANALSSLVPGASEGSLFGPSDVPIGPPSGIEDGRMSSFTENVPWSPNSAAWNQGHHLDGPYRPFANRPQPLQYPWQTYPHQQQFGYPSHMALPTSQPEYLSEPHIPNNLRDNVQNVDAVAMEMANLRFESTAGLSQNNMDNIPVDDLNIDLTPPAGMGGIGLNDPMWERQEGNWAPSLTSSFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8D9</accession>
    <name>A0A8H7U8D9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sequence orphan</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8D9"/>
    <dbReference type="OrthoDB" id="275936at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038781">
        <property type="entry name" value="C365.16-ike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845:SF1">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2173120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="30511" checksum="F941F2A8F9B47207" modified="2022-01-19" version="1">MAIAHSNLSQQPLESMATEKSKSLTTLVKLFSIDMAAAASSSFAVSPMIAIVDRSIIENTNGKTPLVQGLKQGFAAFVASPHRFITTRQFRLVFAIYFSTYMTANVIDTTSEFYQREPTETAAAKFVGTTAVNMTACIIKDRAFTRMFGTVASKPLPLFSYLLFASRDSLTILSSFNAPPIVSKYIQTEGILNSSKMSDTIAQLACPAVMQFISTPLHLLGLDLYNNSNSSSGQRLSLIRREYVKSVLARVARIAPAFGIGGVGNNYVRSYRQQFLPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8M7</accession>
    <name>A0A8H7U8M7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8M7"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="255" mass="27964" checksum="261E3DCD73382AF0" modified="2022-01-19" version="1">MSNVNTSSESLECCRRGEIHSGNSVGKTTSIAGIDAYFTAAPSGSPSGALLYITDAMGWEIPNARLLADTYAAEANIDVYMPNFLAEMSLTPSVLKAGKVDMQTWAKKSIERRPQHHDEIHNVLKELKFKYPKIAASGYCWGGFYSIRLATHEDVIDCAIASHPSLVEVPKDIEDVKKPILFVCAEEDSQFGDEKREKTKEVLTQKGVGAEFQYYPGTTHGWTVRGETTGPVAGAAKKAKDDTVNFIRKHFGVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U931</accession>
    <name>A0A8H7U931_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002885</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U931"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF23">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2171263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="656" mass="73852" checksum="D0734BC300C7E114" modified="2022-01-19" version="1">MSSDGENDINQGPACVQCRKKKHKCSRGEPCQSCLASGSTCFYTEYKKRGAKPGYIETLTRRMDQLESLVLGQSLLLASQGHIPPIKNEDTLKQTLDQVRNTLNSAKSNGSAEMASNHGSPQQERERKRKRSYYSETDFDSILPPEGLLVELVRLHFERIHPWIPILHQLTFEQNFKTRNRSEIVLAAITAATIKFTDLDHTQQKYYYKRCRQAVILASMDRFSVETLQASVIIAYDTIGSGRGPRSWSIVSSATRVVEQLGLAGEDDDMEKNKLLNRVGFLSPPKNLTETEERRRIFWSIFQMDRFCSVTTGWNTSLTSTDVKRRLPTNGEWFKERIYKQARYFNISDPDVDSTDANDALGGYAYLIEATECLNRVACFLLREKIDFTTRDGLRRWFDGFQALDAMLVRWKTFLPEKWQVATVNPTGGMDENLTLAHISHNTSVLLLHHNVAYPPTDLNIRLPSLNSSQTCFAAAMEITTITSQFLVHVRIAVSPPFAFCLFVAARTILAHSLHYRTDLDPSFGVLVQSLREISKRWAANGPETDNLAGKLATKLEKAKHMNSPINAREAVFEDDEGDDLMFSLASPTLIEGFGTYALHPLASAGDQVITDNANVGSASTISSSSNIEFELPHNLTDFDHIFTWADDPRSVRTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9C5</accession>
    <name>A0A8H7U9C5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_004601</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9C5"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF19">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01812)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="53"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2173227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="496" mass="55199" checksum="2316D6EB456A115E" modified="2022-01-19" version="1">MTEAEKETVYMDDKVQENDLTSLENGPEKVDDDFVEPTPAELKALLWKLDLRIVPFLGLLYLCSFLDRVNIGNAKLAGLTKSITISDSDYNWALSIFFIGYVLFEVPSNLMLKKIGPSKWIPIVMIAWGIVMVCMAAVTSSAGLLIARFFLGITEAGLFPGVIFFTSLWYPRKEQATRVAFFFGCSTVAGAFGGVLAYGIMQMEGLRGLHGWQWIFILEGLPTLILAFVSYFVLPDFPENSKFLNEREREIVIRRLRADAGPATEQHFSWKQFRAAFTDYKVYMHSLVYICGATPLYSLSLFLPSIISGMGFTNLTAQAMSAPPYAIACLFTILTAIHADHKRERGLHVFFPVLVGAIGYLLLIVLKTKGPAAMYVAACITTIGVFSHIPAMLSWFTNNIGGHTKRGVATAFIISIGNVGGAIGGQVYRADDAPYYTRGHAICLALMCTSLLATSTFKYLLNRENRRRDNLTPEQYEKECQGTDLCDKHPDFRYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9G8</accession>
    <name>A0A8H7U9G8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9G8"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2173347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="145" mass="16087" checksum="F4E8351E3262E034" modified="2022-01-19" version="1">MPRTAVRYRDEIGKKGNKPFNLLDCLLQRSTSTTLFIAIKSSLEKLGFRGVAGAASGQIDPNFNGVQGKRVRANAKQIHHIGASVSLAYHVFRSIELKLKDGVVTGNKLDEMPKVQQTNGTHTVWYNEVGEESLETFSNISEKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9X0</accession>
    <name>A0A8H7U9X0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_005217</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9X0"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034890153" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="4">
        <location>
            <begin position="293"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2173797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="348" mass="36654" checksum="91AA218FDAC55997" modified="2022-01-19" version="1">MQIRHFVLSTAVVAMLGSMATAVPVPAFMKRGEHHAASSKKDVAVKACTTEVRNTVLTSTPFYITFNGTISGEPCDAATNGTAASYLLHSTGEHDLLEAVNINGTASKGTTCTITIPDSGYQQVSGKDLFVFVPLVTDSGNQTTIVCGDDDKAVPLNVNMASYDIPGLTNATSTTTSATPTQTQEAHHQHVQHTTTTTTEEPRPTHHHHTTTTTTHHTTTTTTHHAEHTHSHDDDDDDSGSGGGQSYSGIGTWFIPATEGGSQGACGPFESNSELIGALNAPQYGDMSEKSSWCGKKVKVTSGGKSVVITINDACPECKHGSIDLTQAAFKELGDLNTGVLDISWSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UA97</accession>
    <name>A0A8H7UA97_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_003384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UA97"/>
    <dbReference type="OrthoDB" id="2412314at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2178131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="281" mass="31590" checksum="B91FC9B26B99172F" modified="2022-01-19" version="1">MLQTALIKQMWSSMQLGKKAVFSNLQPIYLIRDLLFGSMDRDKSAGFSIATRLSLLEVLNQLQTIDIELGTGNTSTGYKLLYDLLSDCPVDSSTSVSIPNLPGTTLMNRSLPLRKAKSSHNMRNTRTSLKFSSWMYELQITVDQSIKPASFLTGVLDYQFDSSPVHFSQKSLPPTPNEGFCAQSYFRHDTSSPDANGQMTLMSLVDSTTIIYLNTHLKLMRKVIDYPPVELFHQYGPLERENVRREFLKSGFSSIAASLLACPYPDLRNSYIDLLTPLLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAY6</accession>
    <name>A0A8H7UAY6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_005429</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.140:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05001">
        <property type="entry name" value="RNA_pol_Rpb1_R"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="17">
        <location>
            <begin position="247"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1564"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1564"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1756"/>
            <end position="1765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2176195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1765" mass="195957" checksum="A5EE0D8342478B50" modified="2022-01-19" version="1">MSGSNFAYSSAPLRRVDSVQFGILSPEEIKAMSVAKIEFPELYDEGTQKPRVGGLLDPRMGTIDRNYKCQTCGESMAECPGHFAHIELAKPVYHIGFLTKVKKILECVCFKCSKLKVDESNPKFIRARKQRDAKARLRSVWDICKSKMICEGGDDMDIDGLEDEGMVEGEDGEMKRRKPHGGCGHKQPVIRKEGLKLFYVYRSGGGDDSNPEGKQPLSASQALQILKNITDQDLRDMGLSEEFARPEWMIITVLPVPPPPVRPSIQMDGTSKGEDDLTHKLSDVLKANANVKRCETEGAPVHVVQEFEQLLQFHTATYMDNDIAGQPQALQKSGRPLKSIRARLKGKEGRLRGNLMGKRVDFSARTVITGDPNLSVDEVGVPRSIARTLTYPEIVTPYNIDKLQTLVRNGPTEHPGAKYIIRDTGERIDLRYHKRAGEIPLQYGYRVERHINDGDVVIFNRQPSLHKMSMMGHKIRVMPYSTFRLNLSVTSPYNADFDGDEMNLHVPQSLETRAEITEICMVPKQIVSPQSNKPVMGIVQDTLCGIRKFTKRDCFLSKDLVMNIVMWVPDWDGYLPTPAILKPKPMWTGKQIVSMIIPKGINCQTVHSTHPDGETTWISPGDTRVAIENGDLICGIVCKKTVGTASGGLIHTILNEQGSEAAKNFLNGAQTVVNYWLLQNGFSIGIGDTIADRDTMESITSLISSAKDRVQEIILTAQQDKLEVQPGMTIRESFEAKVNQTLNKARDDAGKMAQASLREDNNVKQMVVAGSKGSFINISQMTACVGQQNVEGKRIPYGFKFRTLPHFAKDDHSPESRGFVENSYLRGLTPQEFFFHAMGGREGLIDTAVKTAETGYIQRRLVKALEDVMVKYDGTVRNSLGDIIQFCYGEDGMDACYVEKQKLFNLNCTDTQFEKRYKADVMDKGFKKGSLDFSILKEIENSEEAQRYLDEEFRQLSEDRSILRSFIFTSGDDKWPLPSNLQRLITNAQQIFHIDPRKASDLHPVQVIDGVRQVSERLLVVRGSDKISIDAQQNATMLFQMLLRSTLSTKRVIEEFHLNTQAFEWVLGEIESRFLTSVVAPGEMVGTVAAQSIGEPATQMTLNTFHYAGVSSKNVTLGVPRLKEIINVAKNIKTPRLEVWLTPERARNIELAKEVQVGLEHTTLQKVTAASEIYYDPDPRSTVIEEDADFVDTYYQLEDDNSPVVTQVSPWLLRLELNRGMMIDKRLNITEVVSKISEDFKNDLHVMGSDENSEKLIIRCRIMNDDENKDMDDDETKVEEDVFLRKLEANMLSSITLRGISRIRKVYIVERKEMRLHEDGHFEQHTEWGLDTDGINLQEVMCQEGVDPRKTYSNNTVEIMEVLGIEAARKALLKELRNVIEFDGSYVNYRHLALLCDVMTNRGHLMAITRHGINRAETGALMRCSFEETVEILMEASAVGELDDCRGVAENIMLGQIAPLGTGEIDVMLDEDMLKDIPYENRQYLIPNGVSGETAGFATPGPGFMTPNAATPYDSRSPDWVDFSHPSSPIEAMFSPIGDSGSSSTSVGASPWRGDMSPYAASPGYSPASPGYSPASPNYSASPGYSPASPNYSPTSPSYSPASPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTAQSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPNANNNNKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UB26</accession>
    <name>A0A8H7UB26_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UB26"/>
    <dbReference type="OrthoDB" id="2269470at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="75" mass="7761" checksum="BF8F84740218020C" modified="2022-01-19" version="1">MARFSQVLVLSVGTLAGAAVGFYALEAYKVNEKERRLAVLLERKKQYEQQTLASSSAAAAAAATASSSSSSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UB97</accession>
    <name>A0A8H7UB97_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_004678</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UB97"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="27"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2173304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="521" mass="56101" checksum="2BDCC0FCA3FF3EDE" modified="2022-01-19" version="1">MADISNTGANALESLDNRSFTRHHVKAILVSGVGFLADQYDLQSINILSTIIGYVYYPGTNTIPTVPSSLLSASATVGAIAGQLIFGYLADRYGRKRMYGIELMIIIVGTIGAALASNTPGGVSVVAILCFWRLFQGIGIGADYPMSATIAAEFSNKSRRGMMLAAVFSMQGFGTVGAYIVAIIFLYIFQGAIDASPAALDHVWRIVVAFGIIPCLAALYYRLTIPESPRYTMKVLHDKNAAERDMNAFFNTEGVNKVIDDDDGKYALHKDEQKASWAEFNAYFSQPKNAKHLFGTCVNWFLIDIAVYGLSLNQSTIISKIGYSGGSTMFEKVAHLIVGNIIVVLAGNLPGYWIAIALIDIVGRRGLQLIGFSMLTVIYVILSAGYNAILEKSIGAFIFLYALGYLFINAGPNTTTFIIPVEIYPTRIRATAHGLSAACGKVGAAVASFGFSYAVKSSIGVQGTLGILAGCMFLGAVCTFFCTPETKGLTLVEDDESDNTTYVHSNDIEQSHSENVDTEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBQ6</accession>
    <name>A0A8H7UBQ6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBQ6"/>
    <dbReference type="OrthoDB" id="2434585at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="844"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="954"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="987"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="844"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="883"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="894"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="911"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="958"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1064" mass="115814" checksum="28A59712B7439C06" modified="2022-01-19" version="1">MELPDSAQNSATTNADETNTEVEWGDQQDFDNDFGNFNQFGEEDDDFGDFAAGTAEALHFEGGFEGPSAYVDVLPDTQSVSHDLVGQAPQTSRSLDKHIDADFLKEESDAYLKLYAQESNNSAKTSLHRSETIQFDDVKHDHIEPHRSEDDDVSVNLDRDNHNAADDNSESERDIAHKSQTDCRGSLNLETAADDIMMIKIDTTTDDVSTDCAGESRPANNTVIQSISRVSVLENDFAIPSDEHHNDEHSQFRVHDVHDEQHINPEVDAVIPNGVKMKDVISPELNKNENSETEAEVTVDLSTNSIGKKDVDDFAEFSDTNGTAGISDINDTEDTVGFEHSDDTINTDDFEFTNDDDDDDGFGDFGDAEATDEFGDFGDVEEDQSLENGWEGSPPISMTAHGENEMKKPSIPLDLQSLILSANFKKSEVAISVWDNVLGYLVPLSKEHEKTTTTNETETVEELVKRAHESLYPIITWHALTVNTDDDNGIPKVQWRNSRIEKMYLDALNASREPKIASPIPPSRSSPTVKPGSFSATNSPKSNVDTPKTNVDTPVIKQPLAQKGPEVETTVKIDEPVEILGVSVAQSNTVQVESRKPEEKVAKVPKITTSRLPASDSAPASAASGKELFHLSSVMSPPLANDESPPRPVPIRHASSPAIHAEPVQPTVNENTAVSAVRKSDPRKRHTMEVVPQQARSSSPLSQSFKNVSYSRPLTPTKFSLQSQTMNEISPVQSPKMPWQSSPNASRDSLGSPSLSERIQSPESERLSMDLGPMSETSSQPDISSLSATSPPAVKPEVQDSWLSSNDISFLDTLGGHSGNKPKSKPSSQKLGLGIFDLDIFEAANSPAPNSKPSSTTSAWDTMQDTRQKRGPGSQHDIFYARQPSNVITATLTKSPPARSPPVRSSPAKSTWANPVRNHTISGITTASQKSPPVHSQSPPSNSAFNGFGDFGDFSSSMVQTQPVSSPPSDSRWDVFRSASLSGSLSEWSTELTTPKSPPKHRESNASNSLNVVKTESIIRSDDDEFGDFSTAEGDGFGDFGSATTTWDPNQAYQFPSDPSKGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UC38</accession>
    <name>A0A8H7UC38_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Dihydroxyacetone kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_003914</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UC38"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase, DhaK subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF4">
        <property type="entry name" value="TRIOKINASE_FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="14">
        <location>
            <begin position="32"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="13">
        <location>
            <begin position="406"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-hemiaminal-histidine intermediate" evidence="11">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="80"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2180126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="612" mass="64575" checksum="A4F4A9383A2C8652" modified="2022-01-19" version="1">MTQYSSSTLTALQRYITRDMASHKTVKHLMNDPKNVVVESLKGLCYTNSHLRLLENEKVVYNADIENISKKQVTIIAGGGAGHEPSHAAFVGENMLTGAVSGQVFASPSAGQILAALRKVRSPHGTLVVIKNYTGDCLHFGLAVERAKAEGMNIEMVVVGDDVAVGRAKGGMVGRRGLAATVLVHKIAGAVAAKGASLAEVRDAAQYVIDNSATCSVSLDHCHVPGSSSFASLAVDEMEWGTGIHNEPGAKKTEVKDVKTIVHELLFTILDEDDKDRAYLKLNKANEKVVLLVNNLGGISILEMGVVAKEAAEYLAENGIEVERIISGTFMSSLNMPGASLTLLKIPKNADKLDFSSLLDLTVGAPGWVNNSIRGSSLDVVDKTDGLSDMSVELSNKTAGKIINKEVLVQALRSGAENVIAAEPDITHYDTILGDGDCGQTLKEGSNALLSALSSIDFSTAPAAILAISDILDTNMGGTSAAIYCIFLNAFAIGLVDASSKTADQAASTVSVWADALKLALDSLQKYTPAREGDRTMMDVLIPFINTLHQTQSLDQAINAAKDGAEKTKTMHAKLGRASYVNDESVMSAAVPDAGAWGLLALLTGIQKGLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCE2</accession>
    <name>A0A8H7UCE2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="8">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_003032</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="8"/>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCE2"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009396">
        <property type="entry name" value="PRK12756.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF12">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TYROSINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="9">
        <location>
            <begin position="45"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2177785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="357" mass="38630" checksum="09A7EA1B1D0EFC35" modified="2022-01-19" version="1">MSEFMEDLRVTGYNALLTPSFVQEEYPTSEKSKLTVRQARAEAASILRNEDDRLIIIVGPCSIHDTQAAKEYSRLLLQAKAKYSGELLIIMRSYFEKPRTTVGWKGLINDPDINGSYNINKGLRIARKLLCELTDAGMPVAVELLDTISPQYLADLISWGAIGARTTESQLHRELASGVSFPVGFKNGTDGNVAIAVDAIRAASAPHHFLGVTKHGMTTITNTKGNPDCHVILRGGNDGPNYSEAHISKARNDLQAAKLAGNIMVDCSHGNSEKNHANQPKVSACLSEQISNGDKSIIGLMIESHINEGKQSVPAEGPSALKYGVSITDACVNWDTTTTMLEELANAVKARRAAAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCM1</accession>
    <name>A0A8H7UCM1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_006030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCM1"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="40"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2174968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="447" mass="48510" checksum="7F33EFADF4B12343" modified="2022-01-19" version="1" fragment="single">DNPVPTSYGSLTPPDVFNPSISDEERDVLQTIRPGFGSRGILSTSFNIVNATVGSGILGVPFALSCGGFLGGMTISVFVGCLTAISLMMMIRAGIKSNTYKFAQLSELALGRSGYHLLNVFVFIQSAGSCISYFIIIGDTIPVLLSQLWPNSTLLANRQFVVVVLSLVFVFPLNLPRSIGALAKVSIFSVLLLPIIILTIIVRAPVYAPQHHAPITVFGPNVLDALGIQAFAFACSHVAFNNYLSQKNQSVVGWSWTSIISTFCSWTATMMFGVLGYFTFGQDVQQNLFNSFPPDDTIINIGRFLLAVSLIFTIPMGFYPAREAIQKSIGHDTPDRQPTKLQHYTVTVVLFLGMLYLGATVQSLGKVYAFVGGLASSFIAYIIPGISYLAVFKRSPKSQDESQELLIQGELVDEKACATWWMDITAVVLIFFGLGIMILTVGKAVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UD31</accession>
    <name>A0A8H7UD31_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycoside hydrolase family 12 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_001125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UD31"/>
    <dbReference type="OrthoDB" id="95118at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF9">
        <property type="entry name" value="XYLOGLUCAN-SPECIFIC ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034835587" description="Glycoside hydrolase family 12 protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2175478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="25916" checksum="DFB23A312EFFDDFD" modified="2022-01-19" version="1">MKSLTLFVSAMALLASSASAAPLEKRAQLCGQYSTQTEGQYIVNQDEWNKGAATSGSQCSQVNSFSGNDLAWQTSWTWAGGSGQVKSYANAGLNFTPTKISAITSIPIKFYWTYSGSNLVADVSFDMFTSSSSSGSHENEIMVWLTALGGALPITSTGNPIGTVTVAGTTFKLYSGPNGSTTVWSFVAESAVNNMAADLINFYNYLTSNGHISSSQYLQVLQGGTEAFTGSNAEFTCSLFYAAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UD88</accession>
    <name>A0A8H7UD88_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_001305</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UD88"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01479">
        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="14">
        <location>
            <begin position="269"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="15">
        <location>
            <begin position="341"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="17">
        <location>
            <begin position="584"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="16">
        <location>
            <begin position="700"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="13">
        <location>
            <begin position="817"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2175658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="963" mass="105864" checksum="8D75763ADEEDA95C" modified="2022-01-19" version="1">MNYPPPRPPIARNYGTSTPPIPASPQQYPEMYPRAASAAPHLGPSPSGLRPPVMPHQSFQGRQPSPGPVPPGRQPSPNFMQRSPSPAQSMQRARRHYPAAATGPVVNNQASVPPPQFFSPAQVPTQQQSPNGYSNVSPPAQSPTPTLPYNPNSNQLYGSATQSMSNLSLNDSAQMANGPVNVPLIGQPPHIEDLYASPPSSDLPPNSAVTNAPTTHCDPRLKRCTLNAIPSTDGLLRKSKLPLAVVMTPYPTVCPEDTEIPCVSDTSVTRCDRCKAYINPFVTFMSSGRWRCNMCSVENEVPPSFDYDYSTQQQVDRWSRPELNYACVEYLAPTEYMVRAPQPPVFMFIIDVSSNAVKSGAARTSVESIMAAIDQLPNESERTKIGIMTIDQAVHFYTLLGDEPTMLTISDLEDMYLPRPATDLLVNLNEARAVVDDLLERLQTMHDNNTSVGNALGPALRAAYKLVSPTGGKIVCMQSTLPTVGEGSLSVREDPKLYGTNKESGLLQPGSPFYKLLAKDCSKTHVCVDMFLFGRQYSDVATMNVIPHYTGGKTHFYPMFSANNVTQATKVKEEIKHLLGEKIGMEAVMKTRTSPGLICREFHGHFTTRQPDIMALPNVPRDQTYVVELGIEEEIKAPTVYIQTALLFTTCEGERRLRVVTICLPVTTSLSQIFTSADQVAIAHTIAHQGKYLIAIYMITMNKAATTKIASGTDHIADSIVQICKAYGKEVMASTASGSAHLSICDNLKLLPLLGLGLLKNDAFRQNSNVSSDRRAISIIRLRTMPTDIFLPYLYPRFYSLHNMPQEVGGMDENNRFIMPPALNLTSEKLERYGAYLLENGQDMILWLGKDCVPQLCMDLLGAPNIDAVKTGMVSDLPTLSNPFSSRVTKLIEHIRSSRRGADYLSLFVVKEEGDQGLRAMFLSHLMEDRLLSAPNVAGMHQESANAGMSYYQWLGFVRAKCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UD99</accession>
    <name>A0A8H7UD99_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_008969</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UD99"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009093">
        <property type="entry name" value="PRK12429.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2181386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="269" mass="29055" checksum="8ECBA7B09626BC13" modified="2022-01-19" version="1">MSSSILYLADRVAVVTGGASGIGKACCIKLFALGCTIVVCDTNEESGNAFVKELESTAEKGNKAQAVFMKVDLSKADETLKFAKKVLDQFGVVHILVNNAGTQIIASIEEMSDETFRFMNELMLISPFVLTREFLPSMYEAKWGRILNIGSIHSLVAAPGKIAYTTIKHGLLGLTKGTAVEAGEHGVTVNCICPFHVRTPLVEEQTKEQAEQYNMSEDDVKDKVLLGDAAIKRFLESSEVAALCAFLCSEAANGMTGTEHRIDCGYTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDX6</accession>
    <name>A0A8H7UDX6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_005597</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDX6"/>
    <dbReference type="OrthoDB" id="2503993at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902929">
        <property type="term" value="C:plasma membrane of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024982">
        <property type="entry name" value="Rax2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048266">
        <property type="entry name" value="Rax2-like_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048265">
        <property type="entry name" value="Rax2-like_third"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778:SF2">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12768">
        <property type="entry name" value="Rax2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20842">
        <property type="entry name" value="Rax2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20843">
        <property type="entry name" value="Rax2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034106867" evidence="2">
        <location>
            <begin position="25"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like second" evidence="4">
        <location>
            <begin position="234"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like third" evidence="5">
        <location>
            <begin position="385"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like C-terminal" evidence="3">
        <location>
            <begin position="840"/>
            <end position="1080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2176363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1153" mass="121873" checksum="E5A47B6513C43018" modified="2022-01-19" version="1">MRKQHSKFGLLVLSTASLLGLATSSVDTSYIPNLDLTAFEQLGICGDFAGLSRFVNADQFETLDANTATIIQKYSNNTFERVASTTGAINTACKLPQSGTNDAFDIYFAGSFSNINNTSTNNIAKLDTQTGQITSLGSGLNGPVYTLYCDASSSTVYAGGAFNSSAMMWRSGSWVGMPWAGLDGPVYTISPNPVTNTIFFAGSFQSTMNGVYGNSTVSQPVPLTPPSVSCTCRSVSGGNSASNPNRNNPGSIVCPNSTSTVHNYTWLLEDDTPGYWEADFGDSVTPQSFRLSNVHYDNRGTDQFGILALGSNSYYELSYTDPATGQLETCTKNCSLSNNASISYQDFTVINSFPTQGLRIEIFSWFGCGGGLSFVEIFTTDNILHASNGASNASCSDTPQGSTTTTGNWQESFIQGSYQYALTTTFPSTQLTTNNASILFEPQVAVSGMYQLYVTTPGCVRASACGQRTQVDLTLSLSPGGSSVVTVDQTNTADVRQLIYTGMVSASTTAFAPSIQLKVAKNAASPSSDTVSIVADSIELIANGTGATLVSILEFSMQNFTSNITSYKPLANQLPIGSIVNAIDATSGDLYIGGTFTANQGINNIVKYNYAQSNYSALGNIQLNGSVSSLKMVGSSLFAGGNFTSTANGTIPYWNGTVNSFMLLSDNQTLLVSGTINDSTSNSTLLTNRQFATKNDSWIDPSYLLLGGVSGTASNVNGDIYFGNLLGAETVRASDIALLATDSSISSTPSNLFNSANIMINAGVVWDQQSDASSQMFAVAGHFTVSPSISNVAIFTNNTWSGVNATIQGQVDAMAAVNNLLFIGGNFNTSFNNQQSSGFMVYDVQQQQGKAAGRFSNDDASATAVNVIRINPSDNDTVVVGGRFDNAGSLNCVNICSFNVPASQWQPLGTGLQGTVNDITYANSVLLAAGNFSIQGVATYAATYNAGSQTWSPFNQTLPGPVTSVFVNNAANQVIFAGNTSSSLSYIGLYANNNLTLLDIQLGPSSNIYQVFAVPMQPPHGSSPLASSQTMLMVSGRLDIQGYGNVSSALFDGTTWYPSILSTTASGNPGTIREIFYKAQSINYGVTCKLMLRPNCRSDRREYIDRLILSYPSIDHMPVPLVILVAIGGSLGITFVGVAAGMGVIYFRKLGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEV5</accession>
    <name>A0A8H7UEV5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Plectin/eS10 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_006136</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEV5"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000025">
        <property type="entry name" value="40S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="93"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2183141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="153" mass="17592" checksum="268243F092797C5F" modified="2022-01-19" version="1">MLISKENRKLIYEALFKDGVLVAPKDYNLSKHQEIDVPNLQVVKAMQSLTSRGYVKTQFSWQWYYYSLTNEGIDYLREFLHLPTEIVPATLKRAARPAAAPRRAGGKNRFSKLCDGPRGPRGDRDDYRRKEGASGEFKPEFRGGLGRGRREQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UF26</accession>
    <name>A0A8H7UF26_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UF26"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2183366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="115" mass="13024" checksum="1E2E0420C951AB3A" modified="2022-01-19" version="1">MIEHSYPECTSAVLTGLCTFKAIDPTYRQAEVKSQVVDTAYAILALLDAKYPHVEPIRRACQTYNEATAREWRVASGINKRSIQQKLYNLLSHLQVFFSISALGRYAAIWGDEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGH7</accession>
    <name>A0A8H7UGH7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1206 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_001882</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGH7"/>
    <dbReference type="OrthoDB" id="18869at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009597">
        <property type="entry name" value="DUF1206"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06724">
        <property type="entry name" value="DUF1206"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1206" evidence="3">
        <location>
            <begin position="83"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1206" evidence="3">
        <location>
            <begin position="274"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2179033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="423" mass="46828" checksum="294430CB757E6498" modified="2022-01-19" version="1">MRFSPFKFSKRSIHEENEISNEKPQQATTDNVDLERGDTSSLDNVSSDSDASDQNQQEQKERSRWIGGVSTKHRKIVRIFGQIGFCAKGMVYGIIGVLILTNVSGQETPNNSTGNESPQGAFLLLGGIPGIGRPLLIVMAIGLLTYIIWRLWESFTGQGSDASFSKKKNFFRYRLSPFVSGLVYIAYTYYIMKMIFETPEQQQLTASNKQFPASWANSKIGMAGLGIVGIAFIIGTITQLINCIGGGFISDLRTSEPDFPRKWEAVIVHTAGRIGFFARGAVFCMVSAFMWKTLKDPVPSGNVSVVAKSISSLNTNGGGKFFLVVVGVGLVIYGVFAISNAYYKYFPTPPPSRQPERGVEAGEGHYDPDRNPQEAADEQKRMKKEKKQSRQDAKDRLKAHESHLSNLRKSMQQSAASENQMFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UH96</accession>
    <name>A0A8H7UH96_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_003596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UH96"/>
    <dbReference type="OrthoDB" id="2297601at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2179813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="124" mass="13795" checksum="4055A69F0DFAE1CD" modified="2022-01-19" version="1">MPPKRKPEYEDFQAPLGFRPPLSTVLREQRDIEEATRLSLQLQRVAESGESSSSASIRATLRIARSTVIYTFEEEEDFQEPIALQPRTARIAPSVTASVQASTQSSGITQKVEKVVRLTPSIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHR9</accession>
    <name>A0A8H7UHR9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EVE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_002774</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHR9"/>
    <dbReference type="OrthoDB" id="41445at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21133">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052181">
        <property type="entry name" value="5hmC_binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047197">
        <property type="entry name" value="THYN1-like_EVE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087:SF7">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="4">
        <location>
            <begin position="123"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2186336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="267" mass="30718" checksum="A06C96BD3AB1A355" modified="2022-01-19" version="1">MPPTLRNRKPKDDATNDKAAGTKVSKAKTSKTPTQRNEVPVAKPVKSRKRGKAEATDKAEVKDEEDQENKVVKNKKSKTKQDVKPEGMRLANKMSNSERQGCQIQHRRLERYAKQVLDLSSEAENDTSQWDGVRNFEARNIMRDRMKIGHKVLFYHSNCKIPGVAGIAEIVREGYEDSMCLTNKDTAFDEKHPYHDPKSDKSNPKWFMVDVKFVRKLKRLLPLKELQSYPQLSQMALIKRGRLSVQPVTEEEYNFILSQEDRDVSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIF5</accession>
    <name>A0A8H7UIF5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_004038</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIF5"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF34">
        <property type="entry name" value="LYSOSOMAL AMINO ACID TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2180249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="319" mass="36110" checksum="ADDF884298AF6FED" modified="2022-01-19" version="1">MHSSRKCLKSVGRDKRKETTDGSNHTVSQVIENYKRSSAESLSLPFLLIWLAGDISNLIGCILTDQLRFQKYLGIYFVSIDFTLLGQWIYYTRFNPSTNGVAIEEDSQSTYNYPDLEYQNKSDFPRPVTIPRNYNHLAANGEEQNPLLMISDDTFSPPYSASASPSKWYTLGQMEPRRSASPRIILSAIFMLSMRTKDALVLTSNVAPTTSGIDQLLVGRIFAWLCAFLYLASRLPQIFKNLQRKSVEGLSSALFIFAALGNLTYTASILLSPAMDYHQKVIEAIPYLLGSIGTLVFDVIIFTQFFWYRRRTIMNPIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJ53</accession>
    <name>A0A8H7UJ53_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_000973</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJ53"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="282"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2185060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="33981" checksum="1B91E073DD03E183" modified="2022-01-19" version="1">MPRFGAAGQVVPTGIVPIGIISKANPTALTNPNFPLRGDVIAFLGELVGMTIFIFLALAGVQITLISPAGSGNLVPTLMGPSYDQIQSIAFCFGTAITVALFFCAPISGGCLNPAVVVALLMTGNLPFFRAFLLLIAELVGAILGSYFANWVTSGVLLGVNAVAPGYNNAQATFAEALLTCCLCLTVLFIIIEKNTLVTFAPFVVGTVVFMCHLIGTHIDGTSINPARSFGAAVVTGKWTSQHWVFWVGPITGALFSVIIYVMFKSLRYEVQSDFERDQLTSTVEGGMKDEKDKPDNSNVNMAPPPPAPGVNNEMNDVVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJ65</accession>
    <name>A0A8H7UJ65_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_006708</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJ65"/>
    <dbReference type="OrthoDB" id="2427554at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07992">
        <property type="entry name" value="LPLAT_AAK14816-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="40"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2183697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="704" mass="79602" checksum="E7451CD26FC2210F" modified="2022-01-19" version="1">MSGYMVYDLIAWIFNIMLDIFFREIRPRGSHRIPKEGPVIFVAAPHANQFVDPLIVMRECGRRVSFIIAEKSMHERGIGFLARKMKAIPVIRPQDLAKPGAGRIQLLNRKTDPLRITGIDTAFTKQLRVRDSLVLPRSVGLAEVVEIISDTEVIIKKEFKELKALELLTQSEGTNYKCVPHIEQEAVYNSVYDQLNNNRCITIFPEGGSHDRAEMLPLKAGVTLMALGAMAKYPGLDVKIVPCGLNYFHPHRFRSRAVIEFGNPITISQNLVEQYKLGGTEKREACTRLLNTIYSSLKSVTVNATSYETLMVIQAARRLYKPAHRKLHISQVVDLNRRFVIGYNLFKDEPKVKELQQKVLAYNQLVKYHGLRDHQVPRMSLKGPRILALLMYRILLLTIWGLLAFPGAILNLPVVIVAKVISTNKARKALQASTVKIAGRDVLATWKILIGLVLLPTMYGVYTLSLFFALLQTDLALKWKFVLPAATWTLLPFISYASLRFGEIGIDIYKSLQPLYLTLVDHQSTEQLRQNREKLSQDLTELINEYGPKAFSDFDPDSIFRVAPSPSTSNTVSRSSSQFSFPKIASGFFTQRKEWMDDRNIFNWGKVEDSDTEDNLFFLGRSFSGNRSRSGSASEIDSGWTPGSRNRSRTSSVSSNNGESFKVESMTSLPKTTPFNDINNGLKQRPIFKIEDFDQVQPKEATTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJH4</accession>
    <name>A0A8H7UJH4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein MSH3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 13">DNA mismatch repair protein MSH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">MutS protein homolog 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_008837</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJH4"/>
    <dbReference type="OrthoDB" id="121051at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000008">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000004">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000004">
        <property type="entry name" value="DNA mismatch repair protein Msh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000870">
        <property type="entry name" value="MutS protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF122">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="17">
        <location>
            <begin position="872"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="616"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2181254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1019" mass="115153" checksum="B5C9E3200421B095" modified="2022-01-19" version="1" fragment="single">MKTKQTSLGSFFKPAQSSFQIHRDPPSDSSLHAASESAFFKEDAPARNDTQSNKDSKLANKYSFSENVVSESSERTAQQESLHQQFVAKFGEVTDNRPAVKKFKANDYTAKGISQPDSDALKHKSNIKYTPLELQIVELKEKYPGVLLVVEVGYKYKFFGDDAKVASKTLNIAHYMDHNFYCASIPTHRLPFHVRRLVNAGYKVGVVRQTETAALKAVGDNKQGPFLRELKNLYTKSTFVDELVVSDIEEDSGASAGSNYLMTIVEELRGGGGPDERVQIGIVAVQPATGDIMYDCFEDTYMRSELETRVLHIQPSELLLPATLSRPTEKLVHHMAVQRTTAFGDSVRVERVAEDIPFSKNYNAAFTHVSDFYAQSVKSQTSSQEGFKSETLFAEILRLPEVVIKSLALTIKYLSDFHLEHVFKLTKYFTHFSSKSHMTLNANTMANLEIYRNSTNYGEKHSLFWILNHTHTAFGKRLLKRWVGRPLVDRAHLEARINAVEELITAENPKIKELASLLRQLPDLEKGLCRIHYGKSSPAELLKVLNALQRISQVFINTMPMENTRFISPILNDIVDFLPTILEDVISLKSMLNIKAVERGDDMSELFQSHEPWPEISEFKEKIHETEQEFTEHLKELRKLLRNSTTSYVTVAGIEYLIEVKNTELKKVPQNWIKISGTKAVSRFHTPFIISKTRERDQHRDRLRIASENAFRDYLQQVADKYELFRDVVQRLAHLDCLLSLAAVAKQPGYCKPEYVDHVSIKVENGRHPMVEQLLGGNFVPNDISFDSNDYRTMVLTGPNMGGKSSYIRQVALITIMGQIGSYVPADSAQLGIVDAVYTRMGALDNLLTGESTFMIELHETSDIMKQATPRSLVILDELGRGTSTHDGVAIAYAVLQHFITQIRSITIFVTHYPSLAELVNEHSDIAKNCHMAFIEDKVDDDQSTLTFLYKLTDGVAMRSYGLNVARLANLPKDVLDTAFKKASEMEATHEANDDVKAVQRTKRVLHALFDRNRPLHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJY9</accession>
    <name>A0A8H7UJY9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJY9"/>
    <dbReference type="OrthoDB" id="10381652at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="88" mass="10219" checksum="0FBE7C04D3F9E075" modified="2022-01-19" version="1">MPQPAAELSRNQLHAQLSPNVSVTEFHASLLFMRWQLNQKPHTETPELAKKQAEKIRNEEKNKEQRPSPLSEEAKKKFEEINSKNAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKE2</accession>
    <name>A0A8H7UKE2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_007051</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKE2"/>
    <dbReference type="OrthoDB" id="27823at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120104">
        <property type="term" value="C:mitotic actomyosin contractile ring, proximal layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF7">
        <property type="entry name" value="NOSTRIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="10">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="503"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="372"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2182124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="64352" checksum="75B2D7A1F5A36743" modified="2022-01-19" version="1">MALGKDETGSLRLLLDGVRQELETVGMNNIDLAQRIRSNLETPLQNFITDQRDQRKLTKEKYYTECAKMINLQNSLETCMAGREYEKIKQKHEKSRLEVKTTDKEYQAACTGLKNLIRQWQHEWKVASDKFQEMEEKRIEFLHHSLCVYVNILQTVTDQERESHERIWERLDQCDVEKDIEHFIETHGTGGHIPEPPAYVDFFSETRDDQPKYSIAHFSGRRDSKRESKRSSSSNIYQSKSEDESRRSSSKQSHHQSASNRLSLSLERESRQLSNGDEEIFIEDTAQGVIVPVVTKKNGNVETTRSMTQSSDDVFHTTERPIAHERGDLEHTNSTNSKQSFVSRLSRKLSQNLDRSFDQAIEGLKYKMDKGRESTDVEYGSSKASARSNSYRRAPSPTRNSSSSSASKTARSSSPYVPGGWPNSEPKVSLSTSAKVTSDRTGAVHSPSPSYSAGTNKGAKGSADSPGSIKMHAPPAMRKPAQQAAVQAPSQEKQVASHDGGEPILCWAIALFDYHAKYDDDLNFERGDWFAITQMDEGGWYMAHAWNATEARWVGRYGYVPSNFLQPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7ULF7</accession>
    <name>A0A8H7ULF7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_006154</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7ULF7"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="6">
        <location>
            <begin position="31"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="6">
        <location>
            <begin position="353"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2183159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="434" mass="47916" checksum="B2A0DC4FD0EA442D" modified="2022-01-19" version="1">MSSSKVNSSWDFVQPTQVPVGAPVEPTNSLLFSPLTIKSTTFHNRIVVSPMCMYSSNDGLFDPQFHMAHYGTYALRGPGLMFIEASGVAPEGRISPQDMGIWSTAHRDAFKPIVELSHKTGVKIGIQIAHAGRKASTFAPFRKGTSAHKEGVDDAHGGWEPVGPSSIAWDDTFRVPHEMSEAEIQKAIEAFGQSAKWVDEAGFDVVEIHGAHGYLITEFLSPLSNHRTDKYGGSFENRTRFLLEIVDVVQKNWPADKPLFVRLSCSEWHNKKDEESWDFEQTLKLSAILKEKGVDLIDCSSGGNTSTQSFSGANPEDIKLADAPAPEGFEGKTLGHTKYGTLQEAKKHAEAMMNPMTMFQVPFAKDIKAKVGIKTGAVGFINHPYHMESIIRAGYADLVLMAREFLRDPNLVYNAAQELGVNVQWLGQHERGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7ULW2</accession>
    <name>A0A8H7ULW2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_006600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7ULW2"/>
    <dbReference type="OrthoDB" id="2448082at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034914804" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2183594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="38494" checksum="777F900F1B8C0BF5" modified="2022-01-19" version="1">MRLLTLAIAYLLFCDGILCRHAVNEDEVVSPIQATQYQRPPHKKESSINHKNFTTTTTTFTPKSSATGLSHKHADPLDVLNNIFSILFSPSSTSTTSNVISSSASLSTAPHHISVHRATETKSVSQHHTAYISEPTTHIKDSYSTASHAVHTTMITKSKSTVTEDHTNPSRKQKNLHVKSNHYKGKTKHDNDSDDDDDDNDSDDDNNDGDGGGKRTSTSSSIRPSFTMLSALPSLTATAPDPKKSQIESEMVAAERTNKIIGIVVGLGCVAIGSAGLIGYILSRRQDRRQEQLLADGSVQTRWRPQSFLAVVSTAVNRIQHNCSRDSSFKHNATNTNQGMPTSMQTVEHGYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UP65</accession>
    <name>A0A8H7UP65_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TAFII55 protein conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002402</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UP65"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090324">
        <property type="term" value="P:negative regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20265">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045296">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="7">
        <location>
            <begin position="58"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="211"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2185964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="464" mass="53917" checksum="5909785AC3E3CB1E" modified="2022-01-19" version="1">MSDSPASEKRQRKPRQASSLRSASDKKLKIKLTAGKEAHREHRDHSGSEDELEPDVAIEEQFILRLPPGEACEKLRDMVRRRDVTDDVKFIFKDPRHGNFYINGQKFDTKLVDLPTIIESQKTLDQKQLYKIGDISQMLLVEPHSQDEPNALNNVRRNAEFYLYPDGITPPLKHVRKRRFRKRLSKRTIEVVEKEVERLLEVDATAEDVRYEMNDNRDMGQDSDAGTQDIDVEDTDEGSESDEDLAAAIDRGLEELEEEDDDDEDDSDDEDDDDDDEDDDEDDEKGKHSEIAQKRQEILEIKAAIQRKNVDLNSATNAILKQRFETVLENLKKQLALKEAHFPNNVIFCHSMRFRPPIAVMPFANPQLRSEVIALYKQLVYLGREYPMGYTNFFRPKLKAAFMKKSELQDEEEIRKSIALGNYIIKELEAMYYLKKYRTLRARYTVPEQEAYNSLQKKLEAEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCH6</accession>
    <name>A0A8H7PCH6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_009019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCH6"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="162"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="322" mass="36590" checksum="B99D2767B91D043B" modified="2022-01-19" version="1">MAEQKTYMKIDLSDYDNRKDQITQDLMKACTEQGFFYVVNHGLAVEDIRTMFQASHDFFALPDEIKAHTPMDKSRNAGWEKLAQIRPSTGVADLKESIQMGWQNMDGLWPTQEDAPGFKIEAQKFMSQCQDVSMKILSCLAIGLGFEPDFFLSRHDVTKPDCQQTLRCLHYHDITGKTFPPEYWRAGAHTDFDTLTLLFQRPGENGLEVCPGREASTDFAHGDTWSPISPEEGEIVCNIGDMIMRWSDDRLKSNFHRVRTPKVGEYQGPRYSMAYFNQANKSAIIQGKTKYPEAITAGQFLQDAMERNYKALQALKAAAQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCI4</accession>
    <name>A0A8H7PCI4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DMAP1-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_009020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="69964at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010506">
        <property type="entry name" value="DMAP1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056881">
        <property type="entry name" value="Mug62_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754:SF32">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23024">
        <property type="entry name" value="AMP-dom_DIP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06464">
        <property type="entry name" value="DMAP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24919">
        <property type="entry name" value="Mug62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01137">
        <property type="entry name" value="DMAP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51912">
        <property type="entry name" value="DMAP1_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1304"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1468"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="domain" description="DMAP1-binding" evidence="3">
        <location>
            <begin position="21"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1873"/>
            <end position="1926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2171359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1926" mass="213824" checksum="9359AC7641C5DF16" modified="2022-01-19" version="1" fragment="single">TQLNHQDLTKTHQRLFVMDQDLDVLPQYILEKLKSLQLELEDGDITQKGYDKKRQQILTPYMDLLNRPPESTRSDTQSTQNVDNGSESFVHNQDDLERERELVEQELGPEPSAADVDDFLDFLPSPTRTPAMDFPDVVDQPNLPQSQSTMLQPNEGMDRDLRATQSMTNIGASAATGELRKSLSSDARADTLPAVLPSALDAQYYSRPLPVPPGPMALGRGRPPPELSVNIPGRQTTFGRPPPPPANAQMMARPMPPNPANQFSTFPPNVRPPGYRPGQSTAPYPQRPMYPQQQSQQRPPIPGQPLPLRPMASVNHRPPPAQSAAYGNFPQQPGMRPRNWMPDPNNVQRKRRSVDQQSFISERLDGAGLAKSQTIRNVETASQRDWDTASVRSVNRAGGGHTRSPSMISTVSASQFASPTTVHPPDARFSHRRSASGSSRYSSNGMVSNFRALEPPPQPMTNIGNLSPQTLMQLAGNQMLPLEPREVPPGILDINGHTEMSCFSSIAEILRHRALNTGRTIAFTALDPKGKEVAGLTWEKVNARAEKVAHLIRQKSGLNLGDRAALIYRKSEVLDFVVAMLGCFLAGIVAVPINAADEMAELSFILSSTNVYLALTTDYNLRAFTKDLQSRQQEFPPNIEWWKTNEFGSWYPKSKSGNDYPEISLPDLAYIEYSKAPNGELKGVAISHRTIMAQCAAYKTSVSPPETQSNGRAAINSPDTVVSYLEPRQQAGLILGLLCSVFSGNHTIFVSSTVMDSAAIWVNILSKYRATIAIADYAALQNITRQFSNNRAEVINYNKKQPADLSTMRLLLIDTTIVDAECDAHIAENLLLPLGVDDPMAVVCPMSSLPEHGGMILSIRDYLGPAKLEEVVANDKAEKDGQMSIRWIQADGTSRDYWECLLDRDAFKDSRVVVLATGAEVQEQLATTKAIRATAFGFAMPEATIAVVDPETTALCGPDTIGEIWVDSPSLSGGFWALPKHTEAIFHARPLLIPPDTLYPEPYDQEFLRTGLLGTVVGGRIVIFGLYEDRVRQQKLGAEIGVDEVHFAPDLVKTVLKRAAVENWYVEIDFFYHHACLIFADCFISRFSFSAVFEVLINGEHLPVVVCESSFPREELARLADRVCQVLMEDHGLRVYNVLVCPVNSLPRHFKHGRKHIHAMQCKKAYEVGRLNPVYVKVDVDNTIFNLPKKEEMLDTGTIWQNPAAYEEAIRRGLIYGGGLPQHTGMEPVREVIDERTGFDLNKFSNIVDILLWRTAIHPEETAFIALENKGKDTKAYSWRKINGKIASTAYHLTKKGLRTPSRAVIAISYGFELVQAVLACLVLGVVPIPVEPMDLQRIKQDTTAILNIAFQHGASHILTNSHSDELFKNKQCGVVWRQFQAQGARMPEQVNISKMSKYGKLLGKESGYTVKREWLSPDSIAMITVNHTPDMIQHSARLNHQVIISQCRTQKITCQMRAQRGIVANSLGGYSGIGLLMAVFCGIYVGSPTLLMNSTEFFQSSVLFFEWLQRLKVKDTVTTYPLLQYAMNHITTGEHRRFTLQNIQNMMISTEGRPKPHFYHQMLKYFHANRLGKEAINTVYSNMINPMITTRSYMLMEPITLLVDLVSLRRGIVRVLPPEEEALGILLHDSGIVPSTTMIAIVNPETRTVCPANVVGEIWVVSDSNVKGFTEDDPQTYESKFAASIQGGDPRITYARTGDLGFLWSVQRRVGAINASVEEGQCLFVLGKLHETFHVNGCMYFPQDIESSIERCHPAVPPGGAITFHAVNELVAIVAVKTADAALSIIPSVVNTVLQEHMFLIDVIVVVSQGNLPKTKMGEKQRGRAQEAYMEKSLQAIHTRRITNQNAPLELPAHSESQHNFDNDAASFMSHRRSIKSGQSGPDPSTREDTASAEVYTPHSPAQSQFELPRVDSPAPLDIEFDSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD14</accession>
    <name>A0A8H7PD14_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD14"/>
    <dbReference type="OrthoDB" id="2400172at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034477663" evidence="1">
        <location>
            <begin position="19"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="99" mass="10739" checksum="7576AFD00C84F2AF" modified="2022-01-19" version="1">MKLSLLLVALIPAVLVSAGPLQARGDDDADSKGWDGNAKCDVKGFKISFQKVTDCCLKKNGGSWFHDDTLTCTLPIRKEGPFRKCVKDLGFATAVDCDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDL7</accession>
    <name>A0A8H7PDL7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_001432</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDL7"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="141"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="208"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2171956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="317" mass="35278" checksum="CD8E59B70BDB194A" modified="2022-01-19" version="1">MQATSNSPEFFAPVDPFGIDLDVLPNNIANLFADTPLLSSPSSDDFLSSPSSASDSSMGSPPSSLLQDDPSLLTMDTFSPFENMDFTLLAPPHISSSSSDVCTTATSTPIQSPKITTIQPAMQPQQHVMKVPTAKRPPRQLECFNCKVTKTPLWRRTPDRAHTLCNACGLYYKQYGSHRPLHIRQKPTTVRSSPYPMIQSASASPSPVSQSEGCTECHQTQTPLWRKNHQGEPVCNACGLYAKQQQKQPPAFAPPQVKIERQWTQQDEIDDSRFALLLARMNREQMHGFLSMLERRCIILRGFLHSPESESDMKNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDM3</accession>
    <name>A0A8H7PDM3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cleft lip and palate associated transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_001467</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDM3"/>
    <dbReference type="OrthoDB" id="378564at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="541"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2171990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="658" mass="76343" checksum="F139DCCAB3CF8873" modified="2022-01-19" version="1">MPEATAGTAGGNQRREEENKTFLQKYSGTIIQMVVMWLVSRYLFGGGFQPQQPQQQKDQAAHAPAKGRGPAIVNQDANPTDFFPILPSGVFYNPVPPRLPIEDLPDTFMPLWSAGLPMDLTVYVSEKEYFTDYKRSPDWNAENISWGDWDDTREQKIEIPATKTMQHNGTVYAHIFLRHHDAPINPNNREYIANRVVYYRHTLTKYYPKKTAVKQKNLLKAGSEDETLEHVDEEFEQQHDDAGVQTGMGGLLGNWTRKAPMVAYWQPNVTINIFNEPKMAVPKRTLSPPLWKYFQTDVENTLDQTGVFGFYRPTIFPNEFWTLREHAYPVNESVHTLPLTIHYAPISLMKFQVYAVLDESMKSQQSGPMGGSTAAEMDEMKRMFLETNPILLGTTIFVSMLHSLFEFLAFKSDISFWRQKQDSSGVSVRTIMVNIFFQIVIFLYLMDNNQETSWMILIGQGFGLLIEIWKVFKALKYEVYRVPGALLPRVRLQEHAAELTEQESETKKYDEMAYRYLSWLAYPLLAGYAIYSLYYDEHKSWYSYVLKTLVGFVYMFGFITMTPQLFINYKLKSIAHMPWKTLMYKSLNTFIDDLFAFCIKMPTLHRLACLRDDVVFFVYLYQKWAYKVDPTRANEYGQVGVSPEEAKKLDEEKDKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEV4</accession>
    <name>A0A8H7PEV4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_001498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEV4"/>
    <dbReference type="OrthoDB" id="2369073at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010662">
        <property type="entry name" value="RBBP9/YdeN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15394">
        <property type="entry name" value="SERINE HYDROLASE RBBP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15394:SF3">
        <property type="entry name" value="SERINE HYDROLASE RBBP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06821">
        <property type="entry name" value="Ser_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2172021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="188" mass="21895" checksum="DEDA62204E00394E" modified="2022-01-19" version="1">MKCVIAPGNYSKQPEIENWYPSVARKLRHTTKENGERLFSEVVLRQFPDWKIGRESKWMPFLENVLEVGEDDIIIGHSTGSIAAMRWAEKHKIRGIVLVSAYHSDLGEPTEKEAEYFDRPWDFEAIRNNAGFIIQYSSPSDKLVPIAEQRYVSEQMQSEYHELERRGHFIANTDFDQLVDDLLKHLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEX6</accession>
    <name>A0A8H7PEX6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoenolpyruvate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_004941</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEX6"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000010">
        <property type="entry name" value="Phosphoenolpyruvate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.10">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051549">
        <property type="entry name" value="PEP_Utilizing_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004877">
        <property type="entry name" value="PRK06241.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004878">
        <property type="entry name" value="PRK06241.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43615">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43615:SF1">
        <property type="entry name" value="PPDK_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate phosphate dikinase AMP/ATP-binding" evidence="5">
        <location>
            <begin position="19"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilising enzyme mobile" evidence="4">
        <location>
            <begin position="822"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2172399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="901" mass="99519" checksum="C12503A706EEAD44" modified="2022-01-19" version="1">MKANYVIPFADIDKASLSEVGGKGANLGEMLKAGFPVPNGMCISTFAYQAFVASSSKMTGFFEELQSLHIDDLALVQEFGKRMREHLTTLPIPSDIQKDIEEAWLCTGKDKFYAVRSSATAEDLPSASFAGQQDTYLNIHGFDDILDAVRRCWASLFTDRAIIYRARNQFDHQEVFLSVVIQEMVIPAVSGIMFTADPVSGNRNIVTIDASYGLGEALVSGLVTADMYQLRTEKIGNNFYSYQIVEKNIGSKKIAIYSLPEGGTTTKELSEDQQNSQALSDGSMMALAVFAKRIESHYGCEQDIEWCITAEDDIYIVQSRPITTLHPLVDPLPNNDGLHVYMSFGHGQMMTRAITPLGRSVLRTVVPVGHSEPGDESTWAVTAASHLYIDLTKMLRVPAFGRFFPEFAVNIDERISLALKEVVSRPEFQETPPAKGLKFKLLRFAIPMVWGVFLSLFIKNPKLARDQADTYMDGLVARYESQLDEDHGADRIRHVQVLLSELLPRFFPNLAQHVAPGVLAMKLAEKYSKKWLGDSDEIALMNKALPGNVTTEMGLRVGDLGDIVRERPAVLEYLISKTDKQSFRSGLQDINGGEEFLDEFDSFLARYGARCPGEIDIGNTRWGESPMSLVSSIMAVAKNSQAVGDHRRKHIQANEEAEQAARRIVERVRNTPWGYFKSTVMKRLVTVFRCRAGMREHPKFTLIRIFYKAKQVIMEEATELVNAGKLESASDVLYLGLSELHSVLADTFDGDVNVLVKQRKEQHAKDDIIQPVRVMTSEGEIVNGTRKASNAPEGAIIGSGVSAGVVEGFARIVLSPDTSELEDGEIMVAPFTDPGWTPLFNSAKGLVIVVGGMLTHGAVVAREYGIPAVVGVDNATETIKTGQYIRVNGNEGYIEILPTPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFC9</accession>
    <name>A0A8H7PFC9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Choice-of-anchor A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_004833</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFC9"/>
    <dbReference type="OrthoDB" id="2280597at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026588">
        <property type="entry name" value="Choice_anch_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20597">
        <property type="entry name" value="pAdhesive_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034963129" description="Choice-of-anchor A domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Choice-of-anchor A" evidence="3">
        <location>
            <begin position="72"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2172291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="696" mass="74893" checksum="972F5B1FB132A28B" modified="2022-01-19" version="1">MIVASYIFAVTTLVTTILADTQVVHKAVDFDLSEVNGFVQEPGLKLAEPKLANFLDASCQCNYTSERSWTQLLQFNAIVFGNFETFGSEDILGRLAVGGNLLAPGYVVNSNADAQCYGTNTVPWSQLALAVGGNILSPTTEVHGHWWTGSGGTAIEQNTGCNSPANVDQPFPFSAIQTLLNGYSQAYASMAPNLVLNDDNSIRDLGTLSSGCYNVITLRPCHNSNSNDCITQSNWSFSDHILLGQPNWNGPSNGYPNPNRLLIINVPVFNGETIAITTNQPSVGANNCNLIWNFYPADTNGNYLSAGSFTLIRNTGSPFQGVTLAPSGNILDGSQSVFQGVIFANSYRWNQLNGVEIHNTPSCLNYGFCVPPGQGSSPVVSLSATNSSAQTTTSAASTTPESSPTPPAYTQPASSVTLEFSASSAESTTTVMSSTASESSSSSSEISTTVSSSTSATSVSKIGVSHIAPILSVDTTQITSFTSVTSIGKAPFTIAAPSFTAVNTQISSSTSVTSIGKALNTIAAPSFTAGTTQISSSISNPAPLASDPVPSSASLIPGSASPSTDKCRRHQHHHKHDEYEKYDDEGHAWDNEKDYEHKSHQKFEDDWENNKHKHDDHQPQNADWDDDKHKSKDRQENNDDVDDGKHKHEEKQKNNDGWDNSKHKRGDSEDDGYWEDECEDDTHHYHDGDNDKYKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFE8</accession>
    <name>A0A8H7PFE8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_004863</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFE8"/>
    <dbReference type="OrthoDB" id="302966at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16536">
        <property type="entry name" value="RING-HC_RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="180"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="433"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="570"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="570"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2172321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="693" mass="77810" checksum="837FF0C177093B95" modified="2022-01-19" version="1">MNANAPTFVPLSDNKSSHGDHAQDIKPPHGKPAGDRQQPSKKSHKQLRNNRGKGNRPQKQSNQPSKRNERAQTKHKAAPVDNLRLDDQILSTNKRGQISLNHLLNFSFPEREAPQPVYTQRKVKSVSYQPYNKERFLNANFRFLVNPTGDYTVNLADPDLPINWADIEQVLISKSVPPTCPICLSQPTAARVTKCGHTFCLPCILHYLHLNDNPKKSWRKCPICYDAIYARDLKSVKFMNVSAILEHASVDSYDQVRITNTPSHPVAGDLVDMCLIQRSAFSTLAFPLSPSWPVPDNISSAYSRPGTIYPPWPFTPDAMAFAKFMLASPEYLKSEYTQDVNELKNALAEAKDWDASEEAGFINSAIDIVTTELADIHLRDTADVASSMTMAQNIIQAVQKNDGKRAEAQAKQATASNQDETITPIPEAYQQHQLSRTGSSSLLSQSPDDAPTSNVQKNSADTTTPTYFFYQTCDGQHVYLHPLDIKILKKEFVNYDNFPKNIIVRVSNVEESTLTEELRKKFKYLSHLPLTCDVTFLEVDLKGVVSDETLDTFKNELRVRLKKRSEKLRREEKDKRLADSREQKAKPATWTSQPVDPTIRDDPFFNAVPSDHAVSDEEAVLSEALAASVLETQGGGTGAGPRTVWGTRVIESREPVDDQEEDYDDWGEEQVVVNKKGKKKLVLMSTSARRRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGK1</accession>
    <name>A0A8H7PGK1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PXA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_004995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGK1"/>
    <dbReference type="OrthoDB" id="120967at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="4">
        <location>
            <begin position="86"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="624"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2173577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="851" mass="95221" checksum="B41B5111C48F8AD6" modified="2022-01-19" version="1" fragment="single">TIKAYAETSEHASPWHATAIVMAALPPLTFSIFLAIEYPMLAAVACAFCLGAFTVYMPSHQKTEMTAYSDIIPKRKRELHARSQRSDHVALQLTDTAMVTAATKLIDLTIRDFVSTWWTPMNFYNNVLFETEIRTTINITMMNLERSILAHDTNDLFLGIVYGMANSLIIHMRECREFEDSRLDLAEFTQRNPSSPFSQLLSRKEQHRQLQDLGTSFLQKTVPKEELSSPIVSSFFTEIFASYALESVLDLICDPDYLNMTIVDALNDAKVIDGEHGEDMAEGFRSVVEKAAEDAIATKNESVPSSGAPLNRDEGANQRQVSNDMVHDHKPVPTEGEKLTVDVGMSKSPIRDTHEAGRRNGSITIPGDGSFYKDGQSSYTNRMSEDKVSARTSSPQSSVHELSTTMKQTPSLLFPRGTVSFSIMDISPGDESQKIDIATLLFFVQIERSMSNDQRQSEGGGYILTRTYDNFMALHSALSTRHPRSVSRLSLRLPLDQGRMWRHRSQTNNREALCQNLEKYLHIVADDDVLGADMGFKVFLSKEQNSSQDIDAVKALGIEELSEDSSNASSSKNHLSGPSGQALVDEDRDPLKQQMSPRTQYSKWINKRVSRQNSMKDGIEASPRPSSRQSTDSFVSMPMTGSRQSSEGPVEGYNAQIPGRPSTDLQIRNDGAKLVDETTEPQSVTSAHKKLNAIEVELLIETTFALITEIFQLTEANQSAWLRRTALNLLREVIRRSYSEVISQQFVKYMTEYGSSSYVTSLITTITDKFWPNGIWATAVPVRTSEEKEATKALARELLKARGVPSGARQLIGELNCVDAMERLWARCQDVELNRILGVQLLERTLRPFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PH60</accession>
    <name>A0A8H7PH60_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PAN2-PAN3 deadenylation complex catalytic subunit PAN2</fullName>
            <ecNumber evidence="9">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Poly(A)-nuclease deadenylation complex subunit 2</fullName>
            <shortName evidence="9">PAN deadenylation complex subunit 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PAN2</name>
        <name evidence="12" type="ORF">INT43_005273</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="9">Binds 2 metal cations per subunit in the catalytic exonuclease domain.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Positively regulated by the regulatory subunit PAN3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase C19 family. PAN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="9"/>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PH60"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06143">
        <property type="entry name" value="PAN2_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000028">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03182">
        <property type="entry name" value="PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030843">
        <property type="entry name" value="PAN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048841">
        <property type="entry name" value="PAN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20770">
        <property type="entry name" value="PAN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="512"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="764"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="772"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="973"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="975"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1083"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1136"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2173853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1197" mass="133960" checksum="59BEA8E4339A08A3" modified="2022-01-19" version="1">MESHWTEVHRTCDSDPTKAAPISSLVWDPYQDLLWTGNDKGRVTSYYARDGLQRYTSFKGQVEQQIRQILPNDRGVVNLSPTSLQMRNRRGLVKWNISNEDTRDLHCMTTSTLGNNELLVAGQQDDLLVVNVNLGTISRKVSGAMNTVVMKKASSSRLICCGSLGGEVTLRDPRSMKVEQRVQAHTGTLSDLEVSGNMMLTCGFSNRQGSLMVDPLVKVYDIRMSIRALAPIPFPSGPIFLRMHPRLSTTVFIVSQSGQFQVCDVSNLAMGLHAPAGQFYQIPTSSYITAIDVSSTGETVAIGDASSFVYQYSDRPDYSINAYSDQLETPDPPQSRPNVVLEDSRYEQTTEYDYTVVTSLISGFLAASPLSLIGMPHYTEPLLSNWPSNLLFEVGHPPSQIEEEVLRNMKTIDFVGYAPNPGTRRRNQVVRGNANKAMNAPKFRSQQALELLRGGVVDDGDVPMDGKEAKRKLSVDPTGLKMPSSYGRVEIQYSKFGVEDFDFGFYNHTKYGGLETHIANSYCNSMLQMLHFTLPLRQIAISHIKADCQKENCLCCELGFLFRMLEDANGQNCQATNFLRAFRTIPQAGALGLFEPEQPDNTISYSMLIQNFIRFILEQLHQETYSPNANPMILPSLAAGLEESNPTDTPSSIQQVFGLKTSNYSKCSHCGNEISRTTYPYVVDIMYPKKLATSNVKQDIRIKKRSFASLLKTSINRETKTKAYCVSCQQYQPIGTKKLLRELPSVLTINSGITTAEQANLWRHHANGNGKGTNNSSHTTSPRTDSDSGAESSNGSNKTWLPERNGWQIFGRLLIRIVGDDIEIKALDCKQPVPTEFLVGSAKLAVYELSSIVSQVQNNREVPHLVSQIRIPKTELEDDETSPWYLFNDFLVKNIEPEEVFSFKGTWKIPSILQYTRVDLDQFLDLSNLPSQADLSILFKDISVTKNPARDPPSYQVLNEDEMPKKGTLISIDAEFVALSQEETEIRSDGTKSVLRPSRLCLARVSVLRGESNELEGTPFIDDYIVNSEPIVDYLTDYSGIEAGDLDPQTSKHTLVPLKIAYKKLRLLVDLGCIFIGHGLKSDFRIINILVPPEQVIDTLDIYYMRNRQRKISLRFLAWALLELDIQQVTHNSIEDAKTALLLYKKYLELRENGTFGKVLEDIYEMGRKSNWLKATPKDAIGTPTAAATKAATSFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PH68</accession>
    <name>A0A8H7PH68_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_005288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PH68"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2173868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="152" mass="17601" checksum="15753510151BE2E8" modified="2022-01-19" version="1">MCATYLINSWHVSMATGTAYTCALVCENFVEHTPWSYGTLPLEANQQLYTTGIKTQTVKRKAGKSVFVNDRADVWRTENIETPYMIETVAAQLAENMQEPKDADPKRQYKYLSPARVHHSTNENDFEQDEVEHVVVQMLSVNKQEKQQKHYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PI52</accession>
    <name>A0A8H7PI52_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_004416</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PI52"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034535724" evidence="7">
        <location>
            <begin position="19"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="9">
        <location>
            <begin position="26"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="163"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2174393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="414" mass="45152" checksum="CE590BAEC3389033" modified="2022-01-19" version="1">MAATYIFLTLVLLKAFNAQHSNEPTHIIRFASHRNVTAGDKLIMQQYKKYQTSLHTGAVLASGPDTTSIIAPRNLTTISFGDNFNAVTGTFHSSFIEHLQSHPDIEYVEKNQIYRATRRLPLYHQRMRRALTSQKNPKNWGLARLSNKKKDEVNQYTYDSSAGEGVQVFILDSGINVDHKEFGGRAILDANFVQDESEEDLGGHGTHVAGIIGGSTFGVSKNAELRSVKILDKNGDGSTVNLLQALEHVGKYAKKGKSVINLSLSGPKSKLVNDALSSTTKDYNIPIFVSAGNTADDSCNYSPSDNPDVFAVGATTRDDKVSLFSATGSCVRLYAPGQDIQSAWIGSKENSMILDGTSMANPHVVGIAALLMARKSYKSPNDLYTALTDIATKDELEFYDTSEKNSHNLLAHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIH4</accession>
    <name>A0A8H7PIH4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-nitropropane dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_004205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIH4"/>
    <dbReference type="OrthoDB" id="412383at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF20">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2174184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="35808" checksum="489A148D6222A374" modified="2022-01-19" version="1">MVITTKLTKMLGIQHPIIQGGMQWVGTAEMASAVSNAGGLGLLTALTQPTPEDLRKEIRRCRGMTDKPFGVNLTFLPAIVPPPYAEYVQVIIDEDIKVVETAGNNPGVHIKSFKQAGIIVIHKCTAIRHALSAQKLGVDVVSVDGFECAGHPGEDDVTGLILLAKAAKTLKIPYIASGGFGDGRGLAAALALGAEGVNMGTRFMCTQESPIHDNVKQAIVKADERNTALVFRPFRNTSRIFRNSVATEVVTRERKPDVKFEDVRDLVSGQRGRQVYTTGDPEYGVWTAGQVIGLIDDIPTCEVLVHRMVNEAEEIISQRLGSMVQPNKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIZ1</accession>
    <name>A0A8H7PIZ1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_005890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIZ1"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034749232" description="Peptidase S8/S53 domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="163"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2174828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="420" mass="44971" checksum="9E371EBAF7F730CD" modified="2022-01-19" version="1">MKIAGVIGFVAIAIVQINAQLIDREPTHLIKFKGKPVFKDGSAEKFFTARFREFSSSAVLQNHIVSSSFDTASLASIDFGEHFHVVSGVFHDTFAQYLHNQSDIDYVEANQVYSADRSLPPPQAHRLSKRVIEDYNSPSWGIARVYHHENTDLKDYRADTESGAGVTVYVLDSGININNEDFQGRASYGANFVATEDEMDYAGHGTHVSGTIGGHEYGVAKAVLLKSVKILDKRGDGSTTGLLKALSWVSANSTPGKSIINLSLSGPKSQLVEEAIAQTAGSGNIPMIVSAGNTGDDACKYLPAASKDAFAVGATDISDTIAYYSAIGSCVRMYAPGTNILSDWYTSDTATMRLDGTSMANPHVSGVAAILLAQKTYSNVQEVYSDLVAIGTKNVLKPPNVQSSNNLTIENVLAFAPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJ25</accession>
    <name>A0A8H7PJ25_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_005748</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJ25"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18621">
        <property type="entry name" value="GH32_XdINV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 32 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="6">
        <location>
            <begin position="346"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2174690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="511" mass="57201" checksum="17796012EC16FBAA" modified="2022-01-19" version="1" fragment="single">EFSISRVGDISWGHAVSKDLIAWEHIADSPALKPDTEYDCQGIFTGCMAPVGSDDIITIFYTSVSHTPINYTLPYVRGCETLSIATSTDRGLTRVKSKKNPIVAGPPLEPTAWRDPFVDSWPQMDSLLDRKTDDYVYGVIAGGHSQSTPTCFLYSYKRNDPTAWEYLGSLANIGHNYRPSRWSGDFGVSWEVCNFFSLQDTQFMVVNAEGCALENRYLKESLPARPVRQALWMAFDLVLSNQGEPKMAPSFSGILDHGCYYAAMSFFDPVGCHYGDGCLRMTPPVINVHFKVGRVVLLCLGNYEAKTFTVSTLGISPIKNLTKLHQNSLYRRIPDMCFATLSSTRHQLDITSRSFEIQVDIQITELTEEVGLSICHNKGDINYDYTQEAIISFSPESERLTVDRLKSTTVNNINTSPDSGAHTLFYTRDPKDGVVKLETLKLRIFCDNSVLEIFANDRFALISRIYPDTSSVKVSLIATPKQNAVSKFDNIVAKFTTIQIWENLLNKPGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJV8</accession>
    <name>A0A8H7PJV8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_001116</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2340018at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15047">
        <property type="entry name" value="7tmC_GABA-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF20">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 156-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="870"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="905"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="935"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="977"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1031"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1065"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1094"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="11">
        <location>
            <begin position="868"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1258"/>
            <end position="1291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2175469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1318" mass="147029" checksum="1BBF9F010D3E59BB" modified="2022-01-19" version="1">MRRKPLLASPIARILKSFALIFAGIFTLCLSVVDARPIKRDDSGYNGNVPKYCCGTILLPDRAISRHDGYVLTVHGVLLGIFLILTGLVLLLRVYHDGELGTNARFVSGFIAMALITWVLLTNFEPARTYGTYRWTIYLVVCFVIGAIGGLIIGCTFHLFLMVLSGLGALAFGLWLLGWKDGLLIPSNWGRALFLSLLVLAGLVIAPMVWFAPIVGAAFCGAYLFMLGLDVFFHTGFMYALLCSLDTNPNHRIPYACVYVGACSDRHRRSNKTPGVVNAQAATSATSPNVQSTTVNTTFTTIASYIPPGACQINAYSVNSTFLYSVNASNLQNYDVAHYPKLVNVGYLMLGQGSTEIGFYSSYGGPGNAKMLAAVMLAMNDFIVNGRDPITKEDTVSIRLIIGDWQYDYTTFCQLYNYPMPDIIVIGTTAISAAASKEEILALDKHLDEYTQLHNTLLVDSFLKYTLYDYYYTNSWWAVPLTTDTRLLYYNRTTFRALNMKMPPPEGDWGVQYWNDWNWTTFVDYATQIRDHGLGHGYQFYGEFDEESKLITLVARSKILDLFPSNRQCNLLSPIFTEILDDFIRPLWTPTAENGMYPTVANLDFYTTEDNEPLIEWLSQPYEDVVPPDFTIFTGNYGDSSILGMNIDTPANTQYSSNWMLDAINGSNLTEESEIGIGYVPASASFLGGSGLALASTSNKTEIAWNLIVQMIDPNQIYLNIINQANGLYPPYDTSSQYPPWSLPQFTVAREQVSHAVPMQYPHTSFPQVSDFENAHIFRQLLLNIVVKNSTNSQAVDAACNVMMEILAPECNSSNWYPSYPETCQPGTQDFVISYEWMNTSGIACKGPTSLPKPYPIACAYANIDTRQSLTMLTLTSICALISIIYGILLFVYRRTAVVKRASFVFCELVLVGSLFIYSTVYFLAGPAYTWKCQLVIWTVVIGFALLFGSLFCKILRVYKIFNNKAFVTLRLTDWYLLKRLGLILVVEILGLIVLAKVDGGPHAVAYSTYTDPASGQDVMQNKCIYGNLGALIYIAVFNLFLIIYAVALSIATWKVPTQYNESKFVIAASYAVGFGAILLAPLIFFVTDPVARLMIIGLTIDFGVVISVSIFCVPKIYTAVRLYRQETIRQHTENNLERVRSGRSCSCGEIHHPWWKFWRHQSDNCPAQLADGLANNGKGFKARQPFIQENIQTKYVNEGKRTSRPLSPGNLGWVYEEDVLRTSRTNYIIRNVNDLNIASNEEAISLTETDCCSPELPAKTLTRRSTTDRRTSSVFSMSEAPRPPLQSNYPQPLSMGDPRWNRGHCPHCGTGFGSNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLH9</accession>
    <name>A0A8H7PLH9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Chitin synthase</fullName>
            <ecNumber evidence="2 11">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_001301</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chitin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 11"/>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLH9"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="593"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="625"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="678"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="703"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="811"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="847"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="13">
        <location>
            <begin position="105"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2175654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="874" mass="98251" checksum="EE621272743C326C" modified="2022-01-19" version="1">MYPAPHGSSPGEYDEFPMQENSFSSRPINRGGGSYNAADPFDDSHTPYSDSMNQPLLHSPTPTPAGGFFDNNSSIGNNSDLHFAAPPSPAAHYGEAPRRQPRRYKTTRRVPLTKGNLVLDCPVPNRYLEAVPRRDQEEFTHMRYTAATCDPSEFVTQGYTLRQALLGRSTELFIVMVRVFSGTLLKQHPASEFPLTFFFSLISLSDYEDEVLFARTMHGVMKNISHLCTRDRSRTWGPKGWEKVTVCIVSDGRSKIHPRTLSVLAAMGVYQDGVAKNVVNGKPVVAHLYEFTTQISVDPEMKFKGADKDIVPCQILFCLKEKNAKKINSHRWFFQAFGPIINPNVCVLLDVGTRPGGTSIYHLWKAFDINSNVAGACGEIRAMAGTAGVNLLNPLVATQNFEYKMSNILDKPLESVFGYISVLPGAFSAYRYIALQNDTNGHGPLEKYFLGETQHGGDADIFTANMYLAEDRILCYELVAKKDAHWILHYVSSAYGETDVPDSVPEFISQRRRWLNGSFFAGIYALVHWRKIWSSDHSFLRKLALMILDLYQTVNLIFSWFAIGNFYLTFFILTNALDSDSLNPKPFPANVAFVFHEVLNYIYVVLIVVQFILAMGNRPQGSKWAYIISIAFFAFLMAYMMFATIWITVVGVKQAIADAAGSSNTFLALLEQSSFRNVIISVVSTYVIYFLASFMFFDPWHMFTSFIQYIFMAPSFINILNVYAFCNTHDVSWGTKGDNTIATDLGVVKSKKDASGEHVLEVAVPTEQQDLNAQYEEACLDLTKKVAPQVQHRDAKTKQEDYYKAFRTKLVLSWIISNLALVSIITNAELLHWFGDEAQRSTGYLGFILWSVAALSAFRFVGTCIYLVFKIFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLL1</accession>
    <name>A0A8H7PLL1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLL1"/>
    <dbReference type="OrthoDB" id="2257429at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="104" mass="11783" checksum="0F2A738C411AF1AA" modified="2022-01-19" version="1" fragment="single">CLTWRRQNKILLYQKKTFTSSIMSDSKQTERKINANIDSFSAEAQQEVTRLRKEIDDLRIRARPKVQEAENFLSSPQVSGFIGGFVAATAVILGYAKYNGGIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLR3</accession>
    <name>A0A8H7PLR3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_005562</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2</text>
            <dbReference type="Rhea" id="RHEA:38959"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLR3"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="UniPathway" id="UPA00661"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000007">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000010">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000005">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF382">
        <property type="entry name" value="ACYL-COENZYME A OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 14" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="16">
        <location>
            <begin position="132"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="17">
        <location>
            <begin position="279"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="15">
        <location>
            <begin position="457"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2176328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="623" mass="69231" checksum="D16C6BEBBAAD6E9E" modified="2022-01-19" version="1">MSSALSLDSSEVNVIRRILQHDNHENRDKMADFMAKDPLYIPRYNVPLSTEREVALQRLTKLAKNHFFSVFDFEKNPLNVFAVHEVAGMCEGSLATKMTVNLNLYGGTVIKLGTKRHRHYLPLADNMTGIGCFALTELGYGNNAVEMETTAIYDKSKHELVINTPSTLAQKHWITNGGMHAKFAVVFAQLIVDDKNEGVHAILTRIREENMKPSKGVRIEEMGYKFGCNGVDNAKLWFDNVRVPAENLLNKYSDIDKNGQYSSQITSRRGRFLKVADQLLSGRLAIASMCLGGTKTCLSIAFLYASSRLAVGPTGKSDTPILTYQLQQRALMPLVAKTMAYNIGLNYCKARWANQSAADADEVIRLCCVIKPLVTWNFEDTATTCRERCGGQGYLSVNRLGSFIGFSHAGMTAEGDNCVLMGKVSKELLGALQSKKASLPAVPDAQNARSWNLDNITSQLNLFRLREQLLVKELATSMQTKMSGQGETLFDVWMKQESDTIQALARAHGERIVLEQFNKVLDDTNGQACKVLETMYQLYALYTIEGHLSWYLLHGLISVENGQQVSALVRSLVDKLTPVSQQVVLALGVDQRLLFAPIAGNWEAYHKEDNGGEWTTALPPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMU9</accession>
    <name>A0A8H7PMU9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007596</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMU9"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF252">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2176942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36692" checksum="1FE07DFB2355C7A1" modified="2022-01-19" version="1">MLLYALYCQFKTLPEPKGPFTDQIVIVTGANGGIGLEAARHYVRLDAKKVILAVRNLESGHDAKKSIEETTKRTDVVEVWHLDYLSLDSVKAFCNKVSKELCRLDIVALNAGIATASWRVSQDGYEEGLQVNVISTALLANLLLPKMYATADQFKVTPRLTILSSESHVQASLDKIPKDQPIIEFLNKEDHYTLGDYYTISKLLEIIYFKQVVKYIPEREPGKPKVILNIVDPGLCSSNLLRERPNPLYPYIKMILARPLEVGGATIVNGGENDNFETHGKYLMSCMVYPPSPYVRSEAGQTDGEKLFKEMTDILYKIAPESKSIYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMV4</accession>
    <name>A0A8H7PMV4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hydroxysteroid dehydrogenase-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_007651</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMV4"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000301">
        <property type="entry name" value="Hydroxysteroid dehydrogenase like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051935">
        <property type="entry name" value="HSDL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006133">
        <property type="entry name" value="PRK08278.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42808">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42808:SF3">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2176997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="305" mass="33039" checksum="6B2FD578808F460C" modified="2022-01-19" version="1" fragment="single">MSLKGTTIFITGASRGIGLAIARRCAQDGANVAIAAKTAQPDPRLPGTIYTAAKEIEEQGGKALPIICDIRSEDQVVDAIKQTVEKFGGIDILVNNASAISLTDTQSTTVKKYDLMHSVNGRGSWLVAKHAIPHLMKSKRNPHMLMISPPLSAIREEWFRDHVAYSISKFNMSMVALGLSGELRPHGIAVNTLWPASVVETAAVKNLLGGEAVANVGRKPDMMAEAAYRVFTKKATCFSGHNLIDDLFLRSEGVTDMDQYSVIPGNSDLGADFFVNPEHFDAIEQWRVAAKELGQKGNEGKFTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMY2</accession>
    <name>A0A8H7PMY2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_007641</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMY2"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF210">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2176987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="278" mass="29602" checksum="2D6C07E305E3F629" modified="2022-01-19" version="1">MESSCTGGIFVVASNNVNLTPNLPTSNVNNTSSSNRRKSHGVTINIQADPDGLGKDNMLFMGRMQALSAGVMIYLSLIDIIPESAKDIGIALALIWMTIGLVSMCLLEAIIEPYTSSGNSEKNDQQRMLHTSMVTFVGMALHNTLEGLSVYLSALKDIKFGLPLSIVIMLHNMAEGIAVAIPIYLATGNRSKVIQLTFFNGLFEPAGVIVAGFLLQSVLTDELLAKLLAMVAGVMLFISGHELIPMALRYAGAKQTIIASVVGTIMCIAVLSIVDALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNM0</accession>
    <name>A0A8H7PNM0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L21-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007726</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNM0"/>
    <dbReference type="OrthoDB" id="1539250at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3260:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2177070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18570" checksum="61DC211536B16B56" modified="2022-01-19" version="1">MPHSYGIRARTRHMFSRKFRDHGAIPLSTYLKTYKVGDIVDIKANAAVQKGMPHKFYHGRTGIVYNVTKSAVGVIVYKRVGNRYMEKRVNIRVEHVKHSKCRQEFLDRVKENARKRKEATEAGEQIVLKRLPAQPREARHISTKNNFPETITPVPYETLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PP14</accession>
    <name>A0A8H7PP14_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear speckle splicing regulatory protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_007952</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NSRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PP14"/>
    <dbReference type="OrthoDB" id="446635at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053246">
        <property type="entry name" value="NS_splicing_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018612">
        <property type="entry name" value="NSRP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845:SF1">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09745">
        <property type="entry name" value="NSRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear speckle splicing regulatory protein 1 N-terminal" evidence="4">
        <location>
            <begin position="65"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="126"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="265"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="273"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2177295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="368" mass="42735" checksum="7A2B27CE2B46D141" modified="2022-01-19" version="1">MSKMKFGLNTSMKKTKPPTIKPKAFGQNDDDEDDKLVGKETKDSHKARINKQLAGYSSASTKKIEEEHKKALEEDPNIFDYDAVYDNLKTAEKMQQDKMKSKENKKARYVEGLIEMAELRKRDRLRADEKKVEREREEEGDLYGDKEAFVTSSYKEQKEELRRLEEEEKKKEAQEAKKKTFNGFYRQLLDEKEAVHAAIVEASIKGVTAQPEPSVGEGEDEEDTELAQQALQEGKDVMLNDDNIIVDKRQLLGAGLNVAKKPKFGTFMSLSDSDPRVQQRQQEYEDYKRKKLAESAAKRSGRGSEPERERMSREVERQMLERKQQEEEEEKKKEEEFKQKLQKRTSEDTVMSAKERYLARKKQKAGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PP33</accession>
    <name>A0A8H7PP33_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PP33"/>
    <dbReference type="OrthoDB" id="2422436at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="456" mass="52645" checksum="DFEF1F5820DC6E8C" modified="2022-01-19" version="1">MSGIIDAFGFKSRHTLYSGTITGDPTLKDSNANKRYIQKRLLDCFLLRKHKEALLLLDALLVDRDEKINIYWKALAGLVLDLFPDRAEQVLGGSFNSLHPMMANDVKDQAQNAMLRYLASKGNHKDVLEWLQMHNNLKNTTAQKVAALSSLKQIDPDWNTIESTKKVHPAAVAKLLGTDDPDSEQDSSDSEVDGDEDNGKNEDRPHETMMAEKKRKHSADHGQTARDNTRDGKKKRKKRRQYSSDVEEDTDEDYVEDPDRISKETGWSMPPRTFHFNMKGANDALSAVIHGRFKSEDAAEQAIVDFYDALQTAMDQSVDNLPLIRILLPYFSHYSEEWFELMKRHCRVDPAGDVNMIKRLEHRCRKLLKSANHEPDQEKYTNTMVELLLERIGYACYDQWTLNKTIQWLDLCGPNVRRRVCRREAWIYRFLQAECQRAPPDTVSLIEKLQKYFKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPE7</accession>
    <name>A0A8H7PPE7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_003069</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34935"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPE7"/>
    <dbReference type="OrthoDB" id="57698at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00858">
        <property type="entry name" value="GlyRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.200:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000158">
        <property type="entry name" value="Glycyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="218"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2177822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="656" mass="74161" checksum="69B820DFC1886A6C" modified="2022-01-19" version="1">MSDPTFNRSQLEQLISRRFFYAPAFAIYGGVAGLYDYGPTGCALMNNIVQLWRNHFVLEEEMLEVDTTVMTPAEVLKTSGHVEKFSDWMCKDTKNGEIFRADHLIEAVLEARLQGDKEAKAAAAGTQVEATVTDPATAKKATKKKKSKVVVVELKPEEKEAYEEILAKIDNYSGPELGEIIQKWGIKSPEAGNDLTPPQEFNLMFDSSIGPTGHLKGYLRPETAQGQFLNFKKLLEFNNDKMPFASASIGRSFRNEISPRSGLLRVREFTMAEIEHFVDPDNKDHPRFDEVKDIKLNLLPASVQLEGKTDITVMTIGDAVAQGVVDNKTLGYFLGRIYLFLTKIGIKTDKLRFRQHMSNEMAHYACDCWDAEIRSSYGWIECVGCADRSAYDLTVHSKKTKEKLVVREQLDEPKVVNKLQLEVNKKVFGPKFKKTAKAVEEALIALSEEGLQKLKDELESSEKTSINVEGQDYELTKNEISIERVTVTEHIREYTPNVIEPSFGLGRILYSLLEHAWWKRDNDEDRNVLSFPAVVAPYKCCLLPLSGNAVFAPVARDLSHQLRAKNISTRTDDSKASIGRRYARNDELGIPFSITIDFQTVEDGTVTLRERDSTKQIREKTEVILQVLKELSEETTTWEKVVETYPAFNAKEADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPL7</accession>
    <name>A0A8H7PPL7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="10">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_003008</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="10"/>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPL7"/>
    <dbReference type="OrthoDB" id="10266385at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000006">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008854">
        <property type="entry name" value="PRK11892.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="11">
        <location>
            <begin position="43"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2177761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="373" mass="40035" checksum="1DEBF64E488EF602" modified="2022-01-19" version="1">MTFLANSIRNAAPLIARQAAVKQTPFALSAVAQKRWKSNTVEMTVRDALNQALEEELAADEKVFLLGEEVAQYNGAYKVTRGLLDKFGPKRVIDTPITEAGFAGLATGAALSGLKPICEFMTFNFAMQAIDHIVNSAAKTHYMSGGAVKCPIVFRGPNGAAAGVAAQHSQCFAAWYGSVPGLKVVSPWNSEDAKGLLKAAIRDPNPVVVLENELQYGLSFPMSEEAQSSDFVIPIGQAKVEREGKDITIVSHSRSVGFSMEAAEQLAKDGISVEVVNLRSIRPLDVDTIVKSVKKTNRIITVEGGWASYGVGSEIAAQIMESEAFDYLDAPLTRVAGADVPTPYANNLETYAFPDTPIIVKVIRDTLNKKIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPU6</accession>
    <name>A0A8H7PPU6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">ATP-binding cassette sub-family B member 10, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">ABC-mitochondrial erythroid protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">ATP-binding cassette transporter 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">INT43_002980</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">ATP-dependent transporter located in the mitochondrial inner membrane that catalyzes the export of biliverdin from the mitochondrial matrix, and plays a crucial role in hemoglobin synthesis and antioxidative stress. Participates in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX). Involved in the stabilization of the iron transporter mitoferrin-1/SLC25A37. In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>biliverdin IXalpha(in) + ATP + H2O = biliverdin IXalpha(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:82359"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57991"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:82360"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPU6"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000048">
        <property type="entry name" value="ATP-binding cassette sub-family B member 10, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000403">
        <property type="entry name" value="ATP-binding cassette sub-family B member 8, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002773">
        <property type="entry name" value="ABC_prm/ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="24">
        <location>
            <begin position="79"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="23">
        <location>
            <begin position="407"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="652"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="656"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="25">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00055589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00072683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00083334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAG2177733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="677" mass="74213" checksum="8790AA81FA349E82" modified="2022-01-19" version="1" fragment="single">VSKLAFRQPPRVISVQSRLWMSTKSATEAVQKKAAEEAAKEKAKKIESETVWRLLSLARPEAKNISGTKKLRTNTFTFVVAIGLLVISSGITMSVPFSMGKIIDFVTKPDSNEFGGLTMPQFFAVVSTIFVIGGAANMGRVLLFRISGERIIQRLRNNLYKTILKQDMSFFDKNRSGELISRLSVDTAVVGKSITNNLSDGLRAIATATVGTGMMLYVSPQLTGIMMLVVPPVAGFAILYGRYVKTLSRQTQTALSEITKVAEERIGNIRTVQAFAKEPKEAERYSLRVQDVFNLAKREAIASGVFFGGAGVSGNLTILAVLWYGGHMVMQNAISVGDLASFMLYTAYVGSSLGGKYHNLLSKCLTSFYSEIMKGIGASSRLFELLDRQPKIPAETGITLSDIQKPIRFENIKFTYPARPQSPIFNSMSLTVNPGTVIAVVGASGSGKSTIGSLLLRYYDPNEGDIYIGDHSIKEINTRWWREQVGLVSQEPVLFAGTIADNIAYGIENATPDQIKEAAIKANCASFIENFHDGYETFVGERGISLSGGQKQRIAIARALLKNPSILILDEATSALDAESEALVQDALNHLMKGRTVFTIAHRISTIRSADLVACLHDGRIAEIGPYDDLMSRENGVFKKLMEHQTVGRPGIKPVSRWEQDIDNEEAKSWDKEQGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQP8</accession>
    <name>A0A8H7PQP8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WLM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_003031</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQP8"/>
    <dbReference type="OrthoDB" id="261960at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WLM" evidence="7">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="235"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="182"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2177784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="31079" checksum="5314E11A89CE97F8" modified="2022-01-19" version="1">MTVIEYKALKKKPNSDLALDLLKRLASQVTPIMKKRGWKVKQLAEFYPRNTSLLGLNVNRGQRIDIRLRSPADDSAFLPFDDLLGTLLHELVHIVRGPHDVQFYKLLEELNTELDELIGTGYKGEGFYSQGKQLGVNRSISSQDARKKALEAAEKRQKLNKLMIPAGGRRLGGDKSAIQRESQFTPQQLAAQAAERRRQDNKWCGGQEETSEEPKPEDYVIRQDDMPILTTSTKRSATDQWECDYCTYINEPLHLVCSMCLQERTTNKKQALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQR6</accession>
    <name>A0A8H7PQR6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQR6"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16279">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663:SF6">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="67"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2178168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="322" mass="36287" checksum="49C2B405AE69A191" modified="2022-01-19" version="1">MSVIEQVIFVGTGCSSNTPALKCLLEKKPSCKVCLSALSEQGWRNRRKNPSVLIRVRDHKDPQGRLRNILVDCGKTFYRMVQLSATFSQSALDIFPRYDIQELDALILSHGHADAMLGLDDLRSWTSGGRLQTSVPIYLNEETFEVVSRAFPYLVNKANATGGGEVASFTFNVIKANESFEIAGLDIVPLPVHHGIYMQTKEPYWCFGYRFGKQVSCITDANYVPPETMEKMKDSDMLIVDCLREDPYPSHFGYHEALALVDELKAKDNYFIGMAHNLEHGDLEQRLAEYSAMHNLNVRPAYDTLKVDISSNGETTESTWRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQZ2</accession>
    <name>A0A8H7PQZ2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_001690</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQZ2"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09913">
        <property type="entry name" value="EHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000147">
        <property type="entry name" value="EH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040990">
        <property type="entry name" value="DUF5600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031692">
        <property type="entry name" value="EHD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF31">
        <property type="entry name" value="AT21416P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18150">
        <property type="entry name" value="DUF5600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16880">
        <property type="entry name" value="EHD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="11">
        <location>
            <begin position="58"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="9">
        <location>
            <begin position="441"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="473"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2178844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="60260" checksum="2A3CB4653A23054B" modified="2022-01-19" version="1">MSFLKSNSRSQTPTLKDGDQYARVINGLKQIYNSKIRPLETTYNFEGFHSAPLTNSDIEAKPIVLLIGQYSTGKTTFIRYLLDKAYPGEHIGVEPTTDRFVAVMHGNEERVIPGNAAAVNQELPFRGLNKFGQSFLSRFQVSQTNSPVLENMTIIDTPGILAGDKQRIERGYDFTQIIEWFSNRADLILLLFDSHKLDISNEFKLAINSLRGQEEKIRVVLNKSDMVSQQQLMRVYGAMMWSLGKVVQTPEVMRVYLGSFWTEKPPNCFEDCRELLEVEQQDLLKDLRELRRNAAIRKINEIVKRARLARVHALIIGHLKKEMPAMFGKNKKQERLLANLDQEFIKIQHKYHLPAGDFPNPEKFRQNLSLYNMDKFKPLKDDIINRVDEALAVDLPRLMSEFPTGNPMLEEQERNPFAGLETYDSQTGTTTHDYWTWAAVDRGAYAPVFNQLGPRDGKISGSQIKPVLMESGLPNDVLAQVWRLADWDNDGYMGLDEFSVSMHLIKAAQNGEQLPEKLPPALMPGRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQZ4</accession>
    <name>A0A8H7PQZ4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Gamma-glutamyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_003166</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQZ4"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000001">
        <property type="entry name" value="Gamma-glutamyltransferase 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000001">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="374"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="426"/>
            <end position="427"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2177919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="58813" checksum="3EE4E1E54899B3EE" modified="2022-01-19" version="1">MVHSLASHETPVTGGLVKGKYGAVAVEAEQCSNVGIDILKKGGNAVDSAIASALCIGVIDSFATGIGGGGFMLIRTPNGTYEFIDFREAAPAAAHRDMFVKDPSKAQVGGLSVGVPGEIRGFQLAHEKYGKLSWAELFAPAINISRYGFNTTRLLAQRLQSASGWIMQEPDFAKVFAPSGKLAVEGELIKRPTLADTLEIIANEGPDAFYEGVIAASIVNATVANGGILTMDDMKNYEAISRPPISTYYHGRKVVTGGTPTSGHVLISALNILERFNLKLLGEVGVNVHRLVEALKYGFAFRTELGDPDYVDNADRLEEIISKDWAALVRHNISDDHTHEPEYYNPKFDNAEAHGTMHLSVVDEDDGAVSLTSTVNLLFGARFMDPVTGVILNDEMDDFSIPGIPNAFGLQPSFYNYVAPGKRPLSSCTPTIIERDSKFELAIGASGGSMIVTATLDVILDIVDYGKNIYDAIVTPRLHHQLMPNTAIVEYDYPKEKITALTARGHDIVVLPSNMKITAVQGVMRAPDGTVYGASDVRKYGQAAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRF7</accession>
    <name>A0A8H7PRF7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_001949</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRF7"/>
    <dbReference type="OrthoDB" id="30343at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000491">
        <property type="entry name" value="zinc finger matrin-type protein 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="6">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2179099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="229" mass="25490" checksum="8C8E693EEE474B23" modified="2022-01-19" version="1">MASNSGFYGSNTGKDTTFRRTWDKDEYAAKAKEREQADKLAEENEERKAKGLKPKHRPSAPQPQRELLKAREEKVVLDANLNKTQVVAVGAAGPASKQPGFYCKVCDVVIKDSANYLDHINGKKHQKALGMSMKVERATLDSVKERMAALKRKKEQPQEEYDLDARIEARQRAEDEAKRRKKERKKAKKDPSTADSTETVPEANDAAAAGEEDEMAKMMGFAGFGSSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PS29</accession>
    <name>A0A8H7PS29_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_002097</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="68020at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056020">
        <property type="entry name" value="DUF7599"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046488">
        <property type="entry name" value="Sfc3/Tfc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007309">
        <property type="entry name" value="TFIIIC_Bblock-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04182">
        <property type="entry name" value="B-block_TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20222">
        <property type="entry name" value="DUF6581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24538">
        <property type="entry name" value="DUF7599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="1351"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="523"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="740"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1317"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1438"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="925"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="530"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="593"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1438"/>
            <end position="1447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2179247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1969" mass="222861" checksum="B3300720EF92D2DE" modified="2022-01-19" version="1">MLDEVISHLREEISLDGSKGTSLKRLWTFTHRFLEEHVRTLAAETLENAIPKDFTPKMDDGIKAKIWDELRNQPDIFFNKSDSIDDTTRENTPIKQEDGHEHDMAVDDQIDAIEDQVEVPQTTAINIKTPNLIAIPEAKSMSFDQMMTEYGNSVVLTTTVNNQMLAITGDSQFTITGASVTDLSVQLLEAVARSREKGITQIELRENFDLDSKSIFYYVKNLIIRGYLIKRPVVVRGSVTQLAVLSRYRMGEDEEDEMEENLVTDPFNEQDDKSANLDGEAAKKRMSRLLETATNQTLTVDDLKSLLGMYNASTQLTRWLNRNINLLEDKGYIERLLVAEPQKEPRKEDGPQKKEKHLRCVHLLKPYLGREAEDHRLAGSEEQNSLDQEQLYDPKTESDILADVPLEYQMYLMAKESGVEGITSVDMHAAMPHVSYKFLSKTLELACKPAVIQDPSLRLYRTSNIEGRKRFYLYYTREALALSSSLAEEVEKPKKGAVSDDIESTRSEIDPFSFDIPDNFKSGRSIAGLHKPKKMGRPRKHPLPSTEETNKATPSARKRANVDEQQNSEQSPVQVQADVITSAADETSNPSGSKKRKTTKKKGKGTASAKSTAAMDVTSASVSQVGDEPVPVAATSEAPFNQPSQQESKKRQAGNDGNEAKVSKKPKAVTQADTAAVNTFTGDSTPRQLGIRAWLETGRSVTPEQAVSPSPECISTASTPAPIGSTVNQPVAIAMHPAATQASASIPPKSASRAKSENRSKNTTQSLFTATYPQVGAPTHIADLKVVDFANNWKATTVNEQAASKLPFKRRQEAILQVLKKHHGAMMFDKIMTDEIAEETNSMGLNAETKLDRKSIIRAAVALGQTRALQIYPLEFKKMSGSAQVSCLFLLPEVSPNDQVVIDYLDTAKERIYVPAGYSQPRSMNIKKEWQVESLEDRIQRLEASLASTEDNEETKEATEQQIKMLEQSKIAVQKRQARPAINVNRLIKIAFRNGYIVPKMIRAKVFMKSLRYLADSYGSNTISTLKLLQGMPLRAFVQTIGVYVASEEVTNVIENPEYQNTPVSQLPLTARRTLWSLKQNLRSRLKANLAVLYYFGLVRPETGDSLVDGSMLVNNIILEDKVKLLDYSRAGLPELEELPISTQAEIDHFWNQLEISCLKADVFPDESEEDTRRRIENARREHAASANNQVFIPGINLTQSWRNRSYLTDEQIEHLNSYVDIPHRQTPIMDPILCEEIASNMKIDLERVIKYYKQLTYKLLRRSKVSRQKQSADEHNKISNDRMTVVDVKSQPEEDGRSVSWRPLGLRRGRKGVIFRRTGRHNAEKKQDDDDAIPISEFPGDDQDHILPPAPKRTRKVWTDQEDELLLYGFAIMKSRRNIRWEPMMQVLKDRKSSSCRQRIAILTKTGHQRSTVYKLIQAWQDIYRQGIQSGELKDAAFRKEKRQSDEDQPGGTSEDMASDEDDFGLGYNLTECLRYFFERLRNDPSILENTQDFSLPNTVDEINEEFNVTFSIADRSRKLLDERLDASRPGSFILKNRILTSTNIKIAVGSMRGDLEIQNTSWSADERISNDIKVILKMILLTPGDQYKPKVAYQTLYRYPVNLVAEAIKVSVAENVMTRKSYYGNTKSTLPPRTFGMADKFLTQLSGTLPQRIFQQAMAYRNHLLRYEEIDFSPVCSSGMMYCLLDMFAHQKAIFRMEDEEEFKKTNLAPFYTNRAIENLKYDFDVKVALENEALPPLADPVAAQSFTEVEEATWQEAAKKFQKGKHSKAREHICSVLYERGSHGVDLVDLKQQLSDKNVTDQQIYEVIGHMREYDPPLAYLVGTANSILVSSIHLRRWLPRLKKVEDNADGKLVPARMWYDMEGEIMQPVLRGCMQLILEQVQRNPGITLSVMLRKLPTVFVSGEIADVLSMLENRKCIKSRTIANPKSPSLFSSPRTYKSMDKAAIANEKVRCYWALPDCWMNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSC4</accession>
    <name>A0A8H7PSC4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSC4"/>
    <dbReference type="OrthoDB" id="2366918at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2179201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="389" mass="44624" checksum="FF5F55D439C6D90A" modified="2022-01-19" version="1">MNHILSLDSSILANILEYLSLKDVIRFASSCRNLRQLTFDTAEVWSGHLLFEDSSEDVDDQVIASLIPHITRSYGIQSLRLVNLNKVSPMGILQVFDQFAHALQDIEISASKNVIKDLTRHLEAFALKLALLQVANLIPLTFLEYRSRSQHYIEQLGSYMSESPKSEEEKMAVCNSHAELSARLRWLRLPTRLDDPPFEQLEKIKITFTDEVENSDRIFATLKFRSLMAYLAGANLESNLDSDVQPHRDTHDGRWYSINRKHKISDLDSKLDDVQPSVVNAQPDYEVNQQCSTDSPTNVPPLHYNPETPSKPTPVDLQDTPKMPINNKRKFAHAEPRPSEESKKARRSPPTSQPIVKVYRYRRRQSSNSEQSEETRSQQHVYRPNPVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PT17</accession>
    <name>A0A8H7PT17_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">INT43_003801</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PT17"/>
    <dbReference type="OrthoDB" id="360161at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17957">
        <property type="entry name" value="DEADc_DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000759">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044764">
        <property type="entry name" value="DDX52/Rok1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF15">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="168"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="352"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="548"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2180014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="574" mass="65652" checksum="CFFB8397289F8922" modified="2022-01-19" version="1">MDLFRLLGGGARFDKKRFKDDIKIIDPSAVDVDEQQVTQQEEDNNVDQQKALLNEIDFFKTTHTIVGGKKKASDSKKNKSKKEQAANGDNHEQLDEEDEEVEEIFQNQEEVQEFRKQNRIRIYGDDVPNPIRKFVNLSTPYYNIRPYIRRNLKENGFDEPTPIQMQSIPIIMKDRDLMACAPTGSGKTLAYLLPIIHDLNGPEKVGYRALVVAPTRELAQQIFREIKRISAGKKFKICMLTKATAATQAQDPKLRQKFDILISTPLRLVHAIQNEEMELDRVQHLVLDEADKLLELGFLEQMDEIFAACTNPNIQKSLFSATIPSGVETLAKTVMKDPIRIVIGAKNAATETIKQELLFVGSEDGKLVAIRQLVQKGLKPPVLIFVQSIERAKELFHELIYDGINVEVIHSERTKAQRDNIIDQFRAGRIWVLISTELMARGLDFKGVNLVINYDFPQTVQSYIHRIGRTGRAGRTGEAVTYFTKEDGPYLKSIVNVMRESGCEVPEWMLTMKKPSQNMRNQLRKSPIERKRINTISSYDKRKIAHKRDIIETSKRRKMEKQTVAKKSDEQSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTX1</accession>
    <name>A0A8H7PTX1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTX1"/>
    <dbReference type="OrthoDB" id="2448307at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF2">
        <property type="entry name" value="TRP C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2180138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="465" mass="53400" checksum="E025EB9271C0ED8C" modified="2022-01-19" version="1">MNEPANDPPNGQWEPKAPTKNFTPNSTRSNIPSFFHRIAQLAWARVTETRETIAYVILSFLTAIFCIVLEAMVLKAHSDEANNVWSSEQQVNRPLNIAYAETWLSLTRLQNENIFFITFQIFQTYLGIDSVVRQNLMQIMAHTIIIFFCAIFALVQLGETLKFKANLWSTDMKSHIDTSDAGFLNALKYEIAIAVGTAILTLIFIYLCKKLSQQFGWNIYKRIGADLKMQKRYRLYQLFIMNLKLDAFFELVFSIFWLVAMVQASYQTGNAPSIVWFAIHIILTVVLIPSFFLARYGARTERPLIMWLFLAVQLLELVDFCIILQQSASTWVFWVFVVCVAIILSLSTFVLTILLTKNFGQGLKPHIQRLFDENYKDFFDSARNPNVKPSNTQDSWVIEDIENTPENSRPPTRNATRTGWKWASKGRSKQPAVHDVDVEKTNMQRYETPTQLEEATVQPSTQAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTY0</accession>
    <name>A0A8H7PTY0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_002026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTY0"/>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040415">
        <property type="entry name" value="SETD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33524">
        <property type="entry name" value="C5ORF35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33524:SF2">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2179176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="225" mass="25687" checksum="C1B66AEBF2A58B86" modified="2022-01-19" version="1">MKRSGRYPLQRARLWWSSLMPMAKDAVNRQPFDNSVGVQQISEMFKVLSAYHKHQLSKEAKHQVAVDALHKSFGFKLRVQPSNLPGAGNGVFLSGTRERGHIVCLYPDGLAVDAKNTGLSSRVHRSLHKRDNWPGAIITSDVSWLTKHPINPLAIGQIVNNNKDPNVRYQEIDLPSTFSLELRQYIPNLYLTDQSIENNWRIVALITTRKVQDEELFSTYFESVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUP7</accession>
    <name>A0A8H7PUP7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_003607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUP7"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2179824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="304" mass="34574" checksum="3A18CF9784751F5A" modified="2022-01-19" version="1">MSHLKFNPSHENVFKEASMLWRSEPDLYRPYSPSLMNGPLIITPESNWTLEHMFAFHMIPSLDLDLRHILHAEYVPSDMVKFNSLWRLHRDDIYDKNYEKLLHSDSPQDAGNQAQIIGCMVQLMHQLSPQLPLLHPCVRCSWKSSGCAIDIFLVGIIPIEQPIIFKYYLVSTGNVRADGVIVFAESRHNEQTAVWIEVKPLMYAPRNKSNYETTLPQEAAEAPAIVQSRGRQHEKEQEHAIFPAAYLSSIQTHKSLPPEQYVVLKQSKTLELVEVSGSFQFSQNMVGIMKYLSAGNAKIGNGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUU3</accession>
    <name>A0A8H7PUU3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleotide exchange factor Fes1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_003685</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FES1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUU3"/>
    <dbReference type="OrthoDB" id="10250458at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013918">
        <property type="entry name" value="Nucleotide_exch_fac_Fes1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08609">
        <property type="entry name" value="Fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nucleotide exchange factor Fes1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="3">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2179899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="294" mass="32604" checksum="BDCC8BDA72CD1910" modified="2022-01-19" version="1" fragment="single">MEKLLQWAIENTDQEQLKKDAEAIKKGELQPDPSKYDPKVIEAILGKDDATRMKEAVACISDPKDTLENKEIALDNLELLIEGIDNAMNLENMNLWPAIIEQLNNEHAEVRKGSAWVCGTAVQNNPKAQEAFLKNNGLEPLLNLLRNTSEENEVRAKAQYALSGLIKHCPDALKQFQEKGGFDVLAEIVKNPDDSAILRKTIFLYNILVLESPSLAQTLASQGIPDALANVLSKAIQEEDEDLAEKTLRTGYTLFEQGGIFVPPKFASEAINARDKFGADNLNFSAAEWNTLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUV3</accession>
    <name>A0A8H7PUV3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008556</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000061">
        <property type="entry name" value="ATPase family, AAA domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="7">
        <location>
            <begin position="995"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="926"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1149"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1238"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="926"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1168"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1238"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1252"/>
            <end position="1271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2180974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1386" mass="156822" checksum="234CB827042037A4" modified="2022-01-19" version="1">MSEPVADGNVRSSQQEESEGLLENGVEMHVARNTRGSTLESVQTGTHSSESKQFKSKPIRERILRQRKQINYAEPADNPLKDTVRIQSNYNHSEEHAAPVRRRGRPPKYNNNTSNYSQSSSRRSEQLHLQSSPSDRTSLSIRSRYPPPRYSKRAHQEDEADVDDDDEENEDYSRLPKKVRRLSRHGDNKDDSSTRYNMRTRSKEADYAVDNRDDLGDDEEEDEDEPEEGDAARENESHSQRRATRYQLRILDSPGDAGSPSVDEERAPNAQYSLRSRKNVSYSEAHSRPDYEQRAGSNAKQFSPSLRATRMSRWRMSNDTSTTNRNLPSEKAYHLRKRAHPPNFYTLPPPPIVPPKAPVSRSHRPLRGASIYRHAGSGSSDEESIRRNVKQLRAGETGSKILPLNLLDLKGSRDDSLLGPAILNDQTSISEKVDGQTFNFESIGGLDHHIKSLKEMILLPLLYPELYANFQITAPRGALLYGPPGTGKTLMARALANSCSTQSQKVAFFMRKGADCLSKWVGEAERELKLLFEEAKKWQPSIIFFDEIDGLAPVRSAKAEQTHTSVVSTLLALMDGLDSRGQVIVLGATNRIDAIDPALRRPGRFDREFYFPLPNEEARNTIIDIATNDWKPPIAADFRKKLAQVSKGYSGADLKALCTEAALNSIRRTYPQIYSSSERLLVSPQDVHVQQHDFLDSAKSLVPSSHRSADAVAAPLTESLSILLREQFDQVKAKVFKIISQKAKTLRIDEGVDEVAHDLSVEQEHFSLTGSSEMRTFRPRLLLSGKQGLGQKHIAAAVLDALDGHHIQSFDLAMLMGDSTPEAICVQLFTEVKRHRPGVIYIPHIHIWWHTVSDMLRLTFINLLNDINPHHPILLLATSEVPFNELPKEVQQLFERCMLGNLAVRHANKTERISFFQGIIARSAKSPKDYTRRQDAESEKAQVHLPKAPPLPTRQLTEIEKQKLKKHDIHVLREFRRELRCIIEDMLKSKRYKYFAHPVDDEEYPEYDTLIRHPMDLNKIMHKINEGKYFRVADFLRDVSIIRYNTEFYHGADDDLTIRAYALVDDVESFVHALNPELIAELAVTAKRRKLVKDEEKKASINHRYFTRTASSITTRGMEKKSNDVPMEETADPEYNDYISKLQDSYDSGLQSSFNSKDPLALSDTEEIVSKDDPKDAPRVETPIPGPIHDTVTEIVSSREAAHATPDKDIIPVSEKVGAIVDVEHNPFAAIVEEGKRQVNEEDKQQDAGHLSNVNTNDELNDPIQNGSSNDFEVELEEDTPAAPSPEVHRTPNDNSESQIDAVVENHKDISPQPDTPKELYIDIQAFHDVVESVADVSDGWSVDELCHLRAELFVAVHNHRMDWDKTNLLQDLLIITRQFALTHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUY1</accession>
    <name>A0A8H7PUY1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="4">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate phospho-hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_008601</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUY1"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000004">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2181019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="291" mass="32538" checksum="9355FCD817359E7F" modified="2022-01-19" version="1">MSDIKTRVVGAPNTLEHRIYFEKNGVPLSPFHDIPLFANAEKTIFNMVVEIPRWTNGKLEISKEDALNPIKQDIKKGKLRFVRNCFPHKGYIWNYGALPQTWEDPNQINAETKARGDNDPIDVCEIGEQVAYPGQIKQVKVLGVMALLDEGETDWKVLVIDVNDPLAPKLNDIEDVEKHLPGLVRATNEWFRIYKIPDGKPENVFAFSGEAKNKKYATDVIFETHEAWKAMMSGSADKNSISTVNVTVDSSAFKVSADDAVIKSIPAANNLPPAPIDSSIDKWFFISGQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVN0</accession>
    <name>A0A8H7PVN0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_008724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVN0"/>
    <dbReference type="OrthoDB" id="5386199at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009724">
        <property type="entry name" value="TMEM70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045325">
        <property type="entry name" value="TMEM70/TMEM186/TMEM223"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06979">
        <property type="entry name" value="TMEM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2181142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="244" mass="27271" checksum="B7A0F1A53745C184" modified="2022-01-19" version="1">MPIIPMNPRLLSGNRTATALKPFILPMGKNGLAKDRLKWPIARYMSTSTSKTPTAADGSIEDEKLIYSAPNAPTVKLLKMFSISSLGIASLSAPPIFYFWNTPAIQAADINGYMFIGALVASTCSTGVLHKFLSPYVNQVYLHHSKNKSLQTISPNTKITLETLDVLARKKRTTIKLRDLTLANGSWLTWRIKKDAIEKQTKLRHEDFPQTKFWLDQRGGVGDIETMSKIVKVVDEEYKSGRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PW18</accession>
    <name>A0A8H7PW18_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_008975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PW18"/>
    <dbReference type="OrthoDB" id="425925at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019459">
        <property type="entry name" value="GRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921">
        <property type="entry name" value="MYOSIN HEAVY CHAIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921:SF2">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10375">
        <property type="entry name" value="GRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="6">
        <location>
            <begin position="727"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="778"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="826"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="650"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="784"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="827"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2181392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="853" mass="96663" checksum="E855C740946ECA11" modified="2022-01-19" version="1">MASNNEDTVEQLRASFQAKEKEWERSRLTLEARLSALADQSTAARRALDLEKKLTQAGSHLKTLAQENARLTKQQQEAAAASNAKVDEHKHMEDQLKQSEQRLKDLENHMTVLKASLEDSEQRQKKVEEENEALRNRAADQDAEVAQQKAQEDQQIKQQQEELQAVRDSEIKAFQDELDQLKAEKHASDEAVRTLLAVIEKLKSESVVRQSNGDTDDHSEDIKESFQVRERELMDLVQALDTLANSNKSVVANEIDLPTTPLLAKIKELEKLVEDGAKAHLDDTANGSAHSTVDDAANERYAEHLKELEETIKVLRDEVKESARKATDDIASHVVNLLSTLMNAEDDDSFTLDNTLPISLSKAIEDLRESVQQQREKDKESIRAAETSSSTAQSELKRQVTSLQLQINQLNDEREQLQSDKDSLQERLSAATEGSEASEQMKLTLDDLNGRLESVTGERDTARKSIQELEANLLQIQNSKSHLEKEHNSLLEKLSAMKNALGPRLQANQEENKKLREHNNELNEACEDLRRECESLQGENTQLRNQLGARDQEASKEIGCLEKELGHLKHRVETLQSEREEWELRAMEESTQRVQIAEQLRNAMKDLEHANEEHRAQTEQRESERTSLANLQAVLEEFQISKELEIKSAVERMEHQLETAKTSLAEYQERATVAENELQQYHRDVEKSQKYEQEIKEKNLLIGKLRHEAIILNEHLVEAMKRIKEGVSDTSVDRQLITNLFVGFLVAPRGDRKRYDILNVIASVLQLSDEQKAQIGLIRPGSGRPSTGHTPSPQGWMSPTGGMEQPEEKESFTDAWISFLLKEANRGTGSRQSLSSASTPRASIDNMENHRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PW59</accession>
    <name>A0A8H7PW59_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA recombination and repair protein Rad51-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PW59"/>
    <dbReference type="OrthoDB" id="420422at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030547">
        <property type="entry name" value="XRCC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46644">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46644:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2180301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="30611" checksum="5C472CE67B6ABBFF" modified="2022-01-19" version="1">MNFRGLSCTGKTSLLTSIVAQSILPSTWEFQVGEDTFSIDLGGSGASVIFLDLDLQFTVNRLYSVALYRVTNAIENSPHEIKTKLLGRDESIQKLILESLGRCHLFKIASIEDFSNTLYGLPRWFEKHSEENVQFVMIDSLSSLLWSKEDQTGINHHMYGSQTEKVHIQITKIIRQMQAKWNFVLCTTSRKIAASTADELPPCWTKFWDFCLDLNRYDNDQTKQLADYHCQLVRSSRSHVPLETSHAQFGLRYTIKDNDIVTFDDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWD2</accession>
    <name>A0A8H7PWD2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008884</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWD2"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034537598" description="NodB homology domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="7">
        <location>
            <begin position="176"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2181301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="452" mass="48280" checksum="2D07EFBD77B12E7E" modified="2022-01-19" version="1">MLLNSRTLAILATAFMATSFVAAQNGMDAQATNSALESDLDEYIYFPMSDDPANPASSLTAAEKHAELVNDNNVKIASNKHAELAGAEPVATLHAQELTPSESLALKSSQIAASVSAKASTLATAAALTPEQQNQLDREQGLLPVLNQNPTKISAQSLPNGALPAVPMVTGCRTQGQIAVTYSEGPSDATARIVKQLNAANAKGTFFVNATWLYSQQYASVLQNTYNNGHFIGMTYRVKNDDSSTLTDDEIRNDIINDAATIHGLINVAPKYVRLHYSDPEDTRTENIIKDLGMVIVGYNLDSQDYDKNSKTDELYKAAFKRQKDTYDAKGSFISIQYDIPDTTSLAAVSNVINAINDEGYTMVRMDGCLNDAKPYKKDAASLEYVGDKFSFNTTGYKEGQTPLARGATADDGTTTVQESAVSNTVSSGTSALTMSLGSFAVTVAAVLVGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWL2</accession>
    <name>A0A8H7PWL2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWL2"/>
    <dbReference type="OrthoDB" id="21266at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070692">
        <property type="term" value="C:CTDK-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032786">
        <property type="term" value="P:positive regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042326">
        <property type="entry name" value="Ctk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024637">
        <property type="entry name" value="Ctk3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024638">
        <property type="entry name" value="Ctk3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291:SF1">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12243">
        <property type="entry name" value="CTK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12350">
        <property type="entry name" value="CTK3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="5"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2181065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="349" mass="40332" checksum="56218CEC311D37EF" modified="2022-01-19" version="1">MSDDDPFECRLQFTALLQKLNASQQSIQKVANYAMRHRRLSEDLYSCVIEELEQASMNARLNILYVLDSLCQASLKSGFQGYVDLVRPDLEKIIAAVVPNDARGMVNAASARKILNTWKQKQLFDKDNIGGLEARLPKSEVRIPEHAKQTFSKSDILRRMEEDRERHKRLREDIWIRSAEESVDAQFDQLWDTTDALDPEVDYKDMAKENERRWPNYPWTAVFDDVDRTSEMPWYDPLWQRPAVQLPNESSLVPSYERNVMYTMHITQEQQNSHHAVPTLLEDTESIDEEMEMAMSSPDVDPTSTIIEQRPMTYSAVSDSNGNQESEEHPSKRTKYDPHLVATSNQATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWP0</accession>
    <name>A0A8H7PWP0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4211 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_008796</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025451">
        <property type="entry name" value="DUF4211"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF160">
        <property type="entry name" value="ERAD-ASSOCIATED E3 UBIQUITIN-PROTEIN LIGASE COMPONENT HRD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13926">
        <property type="entry name" value="DUF4211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="DUF4211" evidence="4">
        <location>
            <begin position="299"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="1668"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="544"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="591"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="564"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="599"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="637"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2181213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="2085" mass="231545" checksum="D217E62FEA884FEA" modified="2022-01-19" version="1">MPPSGQRAVKNSVTGAESQVAASFSSGHHTKTNIKESVEATPSQPTNTSLSTDNLGKQPVIIDLDSQEDTDDKEDTSGMTDNRANSRKVCRIHESSDSEADIEDLSLQSPLKAKRKFIAENDDSDEGTSDSLPKATHQRGHSDANNVSVKNQIRESLEKEPSVELSSSRKQGHSDTSSDEEIHYSHKTRKRRLKSRNQINDVDSTVHIDISSDGSQGSVVETLPSQQPKPASDLKSVDSECDSEDWDVDKAGKGRDITNEGTPEGPMDRFTQRRNGYGAHENRNCVQEESDDYSDDQDDFVVDDDIIDGEKTYKSTAPVELPAEFSTRYQDDTEGHFRTYFEYLMRKSQDPSFRNFHNLDTRFQVAISSVQRLLETCKDKIYTSVWKPEFVEDLSYWPSMSFKALRELDHDCDACQISGKGSTCSITFYGSGYDENYMPLPQIQHGERARSSASMKENEVENEMWLSYADDRPSKDQYWVGSTCFYRARVFHGLVHLQHDLSVEIRAFVDSVFDTLNQEDNAIAISDQNMDYVTKRMDDTGFSDKYTLSMGNQPSRHTSRPPKQKKEIKSHGDTKKPFIKKLKLSKVARLLPNHRKEPQSPSVPDSSIPSTTTARPPSPIAPHTEASTSQSSPVSSPRNTILQPLSRRLQNNVQRNTPRTPRTSNVSIPSTSAMSSHFSSSINASTFSGLFSQIDVTSSIATESSFSRHSMMDDDDKGVSPPPYTSYNSHRRSHLQVVRPHSSLLESNVALDSSVMLSSCISAASTTYSAEVLQDPVTYGSHISAQDIEDQDVTLESSHHPIERHRLYSLLHIAQSHVKAQEQQAQSSSSASPSENVIQNPAAILQEAFEQAQNVNDSQDYAEVYAAVAAFADETNNPSALVWVAQCHVNGWGVPRDAPLGFQQLKSLASLDIQEAYYPLACCYADGLGVDVDKLTAFQWFEKSSECGNNLAQYRTGAMLAQGVGVAQDDEKAFAWFKKSADAGNKYGQYLVGLHYEQGLSVKEDAEKSKEYYLKSAMQDFPDAQSSLGIRLADDGNHKDAVMWLEKAVQNDNTPALLKLGMMYEEGQGVDRNYEVALVHYKAAANRDDPVAQYLLGLNYRMGDLGLEQNYSEALQYLQKSANAGFPSAQRVLGLMYSEGVGCQQDHAIAYGWFQKAAARNDMRAIGLLGNCYEHGHGVQQDYEKALKCYQQAAEAGSDVAEYSMGQLLHMLKRLDEAFLWYTKAAKRNRQNARLMVARYMLHGWGSAPHDPKAAFAQLKALADNEDYPGAYFWLGACYEEGGGVAQNMEKAFVYYLKSADSGDVDGEFQVALMLSNGHGVAVNRKEAFEWYTKAASKGHKTAQFSLGLFYSKGLEGIPQDLSKAQVLFQKAAMQDLPVAISALSKLLMKQKKFEEAIPWLQKGSDFGDITSMRELAILYGKGVGVDQDKLAAFKLLEDCAKAKDTQALFMLATYYHEGMPVEQNLDMALKLYKQAAVQGSSLAGYGIAQIYHTQAQYEKAYPYYRKASQDPTLQSTEVGWTSLFMVARYVLYDYSTATPAQLECISKEEAFTILLELAEQHQFLPAYFYVAECCEQGLGVPQDVDDAIYWYQQTAENCLDMTVESDRRIAHLQSVATTSTPSNELDCIIEESESDSEASEDSRLETVSDERKNDIEWLKDQAQQGSSEAMFYLAKSYSDCGDDDSAFEYYEMAAELDHVDSIRELGKCYHRGRGCVRDVPRAVQLYKTAAASKDHLALTLLGQIYERGFNNAIPRDPEAASQCYTAAMDYGSVNAIYLAAQMHHTRGEYETAIGMYRAAADQGNVMANVMCARYALTGLGGIEKNQEQGFQTLLKIAKAECSEAFNSVAQCYEMGIGTEKNDAQALEWFLKSASVVKDANAMYHIGCMIEEGRGTGESATEALNWYQLANETGRHRSAQYKIGVFHKEGLAGLPQDVGVAQLYFKKAADQGEEKAMQELAQLFWMQKSYSLALIYYEQAASLGVIEANFTLGKLYHSGFKSDEVTIVPQDYASAFAYFCDASNQGDATSTIILGSYYQHGWHVDQNRNTALQIYEKAIEQGGGTLAQLAVAQLQRSSSSESATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PX09</accession>
    <name>A0A8H7PX09_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_008591</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PX09"/>
    <dbReference type="OrthoDB" id="344165at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="6">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2181009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="85" mass="9836" checksum="43A1F8D82810E252" modified="2022-01-19" version="1">MSQQPQFSEQEQRELASFLEAENAKARIQQTVHTLTDTCWDKCISKVNNKLDRSEEACLSNCVERFLDTSLFIVKRLEDLRNSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PX63</accession>
    <name>A0A8H7PX63_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PX63"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2182007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="632" mass="71468" checksum="6DCDF53DEB823E78" modified="2022-01-19" version="1">MGNVQTAEIDLSDRQLTSVTLEQLGASVALPGVYKILAHVKRDRGNRVHRLYLRRNQLAYLPTHFEVLLSSLTDLSLRSNELTEFPKEILALKHLIKLSLASNSISVIPADISKLRNLEWLNLASNTIDDLPEELAKCKRITHLDIQKNRFTSLPSCISRLPNLRVLLAHKNSISHLGLDSIASTLCTLNLSFNFLEAVPTIVYKLPCLEVLILSSNLLKEFPAELCRRNKMLTNLDLHTNKIQGVPIEISNLKRLRRLNIAINEIDHIPSALGGLASLEWLNMNDNKLVQLPESIGDLRYLIKFGIVQNQLECLPDSIGRLTQLSKLDMRRNKFQWLPGSILKLRDQNETTQTVIDNRDETPVRTLRPGIGSLKTILMGENEKLQYFEGIVCDAHDGDTYVLPSNVNNAEQDKLQVLHKVPTLSEVAARSLLRQLSAQEGTQASLKHYSTRQAYLQTLSTNIIPEYTRSKLTNKSRQCEGCLRLFCDSHIYVAELGCMGDTRLDVPVRFRMCSYRCAKIFLATDKTAGQPYEDEALPDGLEALDYSSNEESSDMHSRRRNNDFVPIRNYGFAAASSGKNARLHGFNVLLCLPTEQNATFQRGKLVLSNCSIIRYEPSFWLTTMMMIWMKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXK9</accession>
    <name>A0A8H7PXK9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_007060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXK9"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2182133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="69" mass="7907" checksum="34A3D445CFA15B0F" modified="2022-01-19" version="1">MSRPSLATFKDEICVLFMPLAMSTSTISRTTDLRPNRGFRANCAYRSSIRSIRSTRAICVIYTYASYTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXR8</accession>
    <name>A0A8H7PXR8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008663</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXR8"/>
    <dbReference type="OrthoDB" id="2104723at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="7">
        <location>
            <begin position="86"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2181081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="350" mass="38630" checksum="0C033398B0D52527" modified="2022-01-19" version="1">MAIEKSPRVLSIQSHVVSAFVSGYAGNKAATFPLQTLGYDVDVMNILQFSNHTGYSSWGGQRVPSDDIKQIFEGLEKNGLTKEYTHILTGYIGNAATLQVCREAIEKIKSTNSVTFVCDPVMGDDGKLYVSPEVLPLYREMIRMADVITPNQTEAEALVDMKIETLKDAQKVIDGLHKLGAEHVIITSVHLPREDIPSQLINDTDLDKIMVCIGSSRSSANHDDSENLYKQFLISFPSYRGYFTGTGDMLSALIVARLTEQEQAANTPSDNELSLLAKATFKSMLTLNAVTEKTWKRQKEYVKLQGDADIEGKPESAQAVHQCELMVVQGKQAIENPDSFDHGQIKIVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYU8</accession>
    <name>A0A8H7PYU8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HotDog ACOT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_007162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYU8"/>
    <dbReference type="OrthoDB" id="331699at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="66"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="276"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2182235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="446" mass="50989" checksum="3B534186D62EA170" modified="2022-01-19" version="1">MKVKSTIIDSLISEQKVGSPFTVRPVTFWMDKLLEPEKSKPVVESKAPPKERITVEKTMADSYMEEYLPLKSSPNLLDEYVFFDGRIRLGKILEDLDALAGAIAYKHVDNPPEAPPVTIVTASVDRLDLLLPNQPEDLRLSGHVAYVGKSSMEIFIKVEKMKNYNPDQAVSAKPPSDFSAISADTLLATRFTMVAIDSATLKSVKVNSLKLLTPAEHRLFRFAEDNKARKRRASEASLSKTPPTQEERLYIHDMYLQYSQYEKSRKPLPDNLVWMEDTRMESSYIMQPQDRNIHNNIFGGYLMRRAYEIAFADASAFLKSRCPNLLSMDEVTFRRPVHVGSLLKLTSHIVYAEGYPHRSFQVRVVAEVMDIEKDTLDITNVFYFTLATEDINAVHSEEDRGPNEVKVRRILPRTYGETMEWLEGKRRRTQGVRAKQALYKLTESEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZ02</accession>
    <name>A0A8H7PZ02_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZ02"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF26">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="186"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2182029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="454" mass="51345" checksum="A844016E809EE6BF" modified="2022-01-19" version="1">MVHSESKQDIINCNSIGCCVPLPLDVNPYEHSYNATTVVAKSMLDRLAKRATLLSTNILNVATDLVNYFHEPKKPSWDISTTLLSSLLQALVSHGQLGELDIVRFFTSIPTIPPPFMSKIQEVRFRVGPRDLPGMLRPLDKVETGDREILAEWVMDRSLASMEQMLPSKTDSFVVKVEENSSPRVILYAHGGAMVLMSSKTHRLLTWCVSKSTGLPIFCKYYFLPFQALKICQLAPEHPFPAGLHDVVLSFLHLIDKEEGYGYDPANVMVMGDSAGGGLMLSMMLYLRDHGLPLPGAAALFSPWVDLSMSHDSWSNRKYDYLPLLTEDHPIHATKMYLGEERYPYMLKHPYVSPVFAQNFDNLPPILLQAGGCECLHDEIQELATRIAQSNTYVQLEVYEDMIHVFQAFPFLKASRKALQSVGWWSMYAVNIIHKWQHEVTTLRRELELAKSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZ05</accession>
    <name>A0A8H7PZ05_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_007237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZ05"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2182310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="66" mass="7465" checksum="12E3BDC6B9BF0C4B" modified="2022-01-19" version="1">MNVIRQTLRLTGQHTTLDRVISALPLLVQAAGVIRMRAVVRDFEITWSELDQLLRHMSYGSICGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZD3</accession>
    <name>A0A8H7PZD3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipid:diacylglycerol acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZD3"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2182563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="740" mass="82480" checksum="05DA469F1FE06184" modified="2022-01-19" version="1" fragment="single">MPIRKRAKKPGKANQQNGDTNIDSQFKGVTEAIELKKLLPEDILADSRSMTLDIQPWYRKKIFHFALGLSIGVLAAFGMIAASPASAHFGELQDLVAMYIADMDIASKIPSTDLMDELFANMTNFITPNAPSEQPFMPALEAMDELELSPHFPVVLLPGIVSTGLESWSVSNCSQKYFRKRMWGTTTMFKAVLFDKACWTQHLKLDTVTGLDPEGIKLRAAQGLDAADYFVTGYWVWAKIIENLAAIGYDSNMMYLASYDWRLSYHNLEVRDNFFTKLKTQIEIYKKIHGKKTVVMTHSMGSTLFPYFLKWAESPKGGNGGKSWTEDHIETFANIAGPMIGVPKALAFMLSGETRDTLQLGSFGTYLLEKFFSRRERADLIRTWAGGSSMLPKGGDQVWGNLTWAPDDEVNHETTGISYGAMVTFAQESQELGTNGELSIDDDGVVSNYTSQASIDLLYNSTSVEFNDQLRLNYSYGLTTSKKQLKRNDDDHTTWSNPLESRLPNAPNMKIYCFYGVGVETERSYYYGKTDGGKTVCNAGSGEQCESVNAEKSAEDVMKDDKKLQRMFRAFKARMGDSLPSASVVDDESSSFVSSIRSFMMHVRIQVLMSNLFCIQFIDSTVNRPDENIRTGVRFGEGDGTVPLLSLGYMSAPSGGWTKYADLYNPGHSPIIAREYPHEVSESALDVRGGSKASDHVNLLGNWEMTLDLLRIVANKPENVTQRILSNIEEYAKAIDLTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q025</accession>
    <name>A0A8H7Q025_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_006473</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q025"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2183467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="345" mass="37226" checksum="A39814BA5B2D2E5D" modified="2022-01-19" version="1" fragment="single">MPATTFTSNVGIPVFALGFTSKDQLVIGGGGGSGRNGVTNKIATFKVDSKRKEFREDAAFEFGSEEDAPMCLDVHPTRSSCAVGVNGTDKSIEAGENKNCRVFDIDGDSIKLMESVQTMKSKNVDDHQKVCRYSKDGHFVATGTTDGILTLLKFPSMEPALPSVTFDNEEILDIDIDFDNEKLLVVTPGLVRLISLRGKTAGKELQTIQASGMDKKTKSEFRAVRYGNGVSSDHAFVVLNSKARDKGSVIKLNAHTLEIVKTKKISNKPLTAFAVSKDGSIAAFASSDLSIGVLDTMNLQKLIHIKEAHSFSITSLAISHDRSMLVSASADNKCRAVILPKVYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0A5</accession>
    <name>A0A8H7Q0A5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_006170</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 81 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0A5"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1170">
        <property type="entry name" value="glycoside hydrolase family 81 endo-[beta] glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005200">
        <property type="entry name" value="Endo-beta-glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040720">
        <property type="entry name" value="GH81_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040451">
        <property type="entry name" value="GH81_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983:SF0">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-D-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17652">
        <property type="entry name" value="Glyco_hydro81C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03639">
        <property type="entry name" value="Glyco_hydro_81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52008">
        <property type="entry name" value="GH81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034248164" description="glucan endo-1,3-beta-D-glucosidase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 N-terminal" evidence="11">
        <location>
            <begin position="83"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 C-terminal" evidence="12">
        <location>
            <begin position="410"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2183175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="793" mass="88691" checksum="C8C7E2F97E531EF3" modified="2022-01-19" version="1">MRTQLLLVIAALLSELSPSAAAPSSADFTSGDQLMGNKPSKKQSLFPRGAKSEEPLQRDMKASIFSPISSDSAPDSFQKIVHPFKSPFANQSVSEPIPTNSWLGNLFYPSADNNAPTTSDPYILRVFDKYGGNPGLSIRQPDEKVIGKYQAQNNVPETDTGYFINQQKVDLRFTTVEWKNATPIQNVTSWDMLSANLRLQSQRNTKQYIDFPLVRGMAYVTADYHNLTPQFFSQNAIIEVTAAKSSNKTYSGHKFKLKFNDTPTTYFVIYALGKDPLTLRQVDGQNLVSDKPYNGVIRAAKLTDDSSCESILDENVYVWPIGAKVDAYSDGKEAGYTIEWILNKQGGKEVLQYAYPHHIESLADDHVSITTLNLASSAKGAMTAVIGNKWTLAEKELSQISWLPSNPEASEDAITDIINNLEKETGSDISHETLLDDNYFSGKALQKYALIALMLNSPETKLKNQEMAKTSLKKLKDALLPYIQNKQKDPFRYDTLYKGIVSLSGLPKAEGGTGDPNAAFGHTYYSDHHYHQGYLIVTAAIVHHLDTNWMKKEITQWTETLIRDANNPVKGDGKFAPFRMWDWFAGHSWAGGIKINGALDGRDQESIPESVNFYWGAKLWGLATQNQNLVKLSNLQLAISKRTAYSYFWLKDDNKIMPSGLIKNKVVGIYFEQKADYTTYFGRYLEYIHGIQQLPMTPELGEYIKDPDFVQQEWTQKLEPALNGVQGGWKGVLLANYAIIDPSSAFAQLRTVEVDGGQSRAFSLYFAATQPNFKRICKRITVVILSRTLANTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0R3</accession>
    <name>A0A8H7Q0R3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Nuclear receptor coactivator 6-interacting protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">PRIP-interacting protein with methyltransferase motif</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">INT43_006794</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">May form homooligomers. Interacts with CREBBP/CBP, EED/WAIT1, EP300/P300, NCOA6/PRIP, PPARBP/PBP and SMN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Cajal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0R3"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000066">
        <property type="entry name" value="Trimethylguanosine synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="340"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="341"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="24">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00057179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00064494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00079339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00081504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAG2183783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="395" mass="43925" checksum="B697CBF9A837FD7F" modified="2022-01-19" version="1" fragment="single">MAIHQPSSSPPTSELLPNSPLSEASYDSAELQEAHVVEEAVEPATEPDYDTVTRESGHPQSLLEFAKQIVDNAPANFAATTREEQKQKSKKSRKKKKKGLPVDLTAGMTVEERVEFTHFEGKRVRYEAKEMKGELKKYWYKRYDLFSKYDDGIKMDRESWFSVTPEKIAVHLAERCRADTIVDAFCGSGGNAIQFAFTCERVIAIDIDPIKLHCAKHNAEIYGVADRIEFILGDFMQLAPSLKADVVFLSPPWGGPSYIGAEVFDLETMIPMNGLELYAKAKAITSNVAYFVPRNTDPKQLASLAGEGNLCEVEQNYLQGYLKALTAYYGELLDPSLALQAEEEEDESDEQDTTEQDSSEDESTEASDSDADDNQVNAAGGKRSINDDDTTQRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1F1</accession>
    <name>A0A8H7Q1F1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_000562</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1F1"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF101">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2184649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="250" mass="29009" checksum="041C9337484CA2FC" modified="2022-01-19" version="1">MLMINCMQYLAKQYVYSGGRDEQAKRMFIDVIRSTEKYMVSSPKNHTQHKLLGNLRGNFELEPVMDELACFAPGTFLLAARNIDELRDIEPLAADLLDSCVLAWTSTRTGIAPEVFGWIDDKTGRHNAPIEGRTEELAKEFGVFPITKSYILRPETIESIFYFYRFTKNEIYRDMGWELFKAVQQHCRANSGFSGIVDVDAVSPKWDDREESFFFAETLKYFYLLFDDTNLLPLDEWVLNTEAHPLRIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1T1</accession>
    <name>A0A8H7Q1T1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_000772</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1T1"/>
    <dbReference type="OrthoDB" id="2449228at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034601846" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2184859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="47449" checksum="2D763704D1B61D1E" modified="2022-01-19" version="1">MQPLKWLAALAIALAASDLGAAAHEQNSIATASTRKQSKRKLEHNMPTLANQRLSQTLPNFPRQLLCPIILRTTPTTTTNTTTITIMEPRVFIATTTTPLRLTINRPISVSHHGSSHHEGHGEVHHHSAEKKHTTSTKRTTEHKKHTTSTKKTTEHHHTTTTRIVVHHHSVKTTTSKAHHAVAAAKPTSQPKGNSLVAAGSGSDNDSSANAHPASDSTSSHGNTADSGNGAGPQNDAAVSPEDATPTPDADAIAAPSTVPTPSVDSDPSALSDPNAVPSSSSNSVSVDNIPTGGPVNANVSNKTIGITVGAAIGCVAAVGLAGMMVYKRKTRRRFEDSIGGGNIDGSMDESAQTHWRPTSFMAAVTSVVARLPRDRNSSSSRGSGGFAASVFGSLRRVGSRRSNRSSSSSVSEASHDSMNSHTSFGYAVSGPLPELARVDHNQFQEVDLRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1X0</accession>
    <name>A0A8H7Q1X0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1X0"/>
    <dbReference type="OrthoDB" id="6359943at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369:SF2">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="799" mass="90850" checksum="A1C2A239D85D9285" modified="2022-01-19" version="1">MISSLALHLKESAFNKALYSDVSVTFAYGALPFSLTYNLHKIILVQSHFFRELLQEHETSQHGRIQFTIDLQRALAYKGFLPSLLAGPPIPERRLNYRILGSHIAFALAWLYEADKKSLLESLQPDDIIRVLIIAMLFEINDLTDHCIRLYMSKRLAVNTIVSDLHLIGQLPHSSDYYHELRDAALLILFRSGAEHAESLCELPTDWLQDILSAELLFVNGEFERYVVLKRVLQTFIDELNTSMHLNDAEAIERNKRRLSSFNSQEGSNMKAARDITVEDILLRKRKRLTDDDQDPDKDILATRPSRLKYNRFNSTDHHKTLNQMPNDSPYKAKMEILLGLLNETVIYSNMTFSQLTTVRTDGLVEEGTVFRALWQREALERLMFPTVDLKADKSHETTGSETPANQHDALSEYFDVGVKSGLNQTTIAQRRRLLLGTPRFRFGASIQLDTRKKDEWKEEMIFTGQDDEEEADAFEHMLSNPNEDLASCEGFSSEDETDQENAIVGEHWQGRNRTSLVAGKISSKKALAQLASQKSKDSAGSYIRILRNTFYSTPKVILGTRYRVKVEAFVLSLADSPKKLVCNFELQRSKGKIDFRRYQIRRTARESLEALAVSQNESNSEATVRSRPIYSPSPYMPPARRLPTRQATPSRIPASQPLPAKHTVEMIKNEKTKSTRRRASSTPPKPSIALLKELEGAGAQKAKQMNQSKVRYSVYCLNRHCVVDADSDSLSLVEREDRAFMPVSTCEEMGDETDEHWSATEHVLDNSYTSNVLLTDGVIDTSKIDVMVTLELFDLKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2V0</accession>
    <name>A0A8H7Q2V0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_000724</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2V0"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902554">
        <property type="term" value="C:serine/threonine protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047173">
        <property type="entry name" value="STRAD_A/B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014:SF21">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="146"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="495"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="513"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2184811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="580" mass="65659" checksum="DA4245159C875BEF" modified="2022-01-19" version="1">MAMACATRPHILDPGKHSESWSFMSHNKLPAIVTSRHCLLPRPKSATTTQLTKEDVKHVESFIAPQRPRLNSFFNHTTVENAAQDRLLKVIAPSASSSAILVRPNDYERQRRRASSQSNITDIPRRMSTGNQLKSVPEDVPVFSTKTLYFFLGYGATATVTLATYRKTHQVAIKMVDMDLFEQCQIDELRREIQIMSLCRHENVLPVHRSFMHDSKLCIVTPVMTAGSCHDVLRRYRKGLEEPIIACIIRQAVRGLCYLHRNNLVHRDIKAANLLINRETGNVRLADFGVSSSLLECESRRVRNSFVGTPAWMAPEIVDGSGYDHQVDIWSLAITALELAYGHAPNSKYSPIKVLISTLRDAAPILDPAQCCHDYSPMFAQFIRLCLNKDPQLRPTAAELMKHPFLTKAPPPAYLVSHIKTYTIMELQARSKEAKLVHSIVLTLQLPTLDFREKKKHFDMLFADPWEFPAAPQPNHKQRETGFYIQDPISNTVDVDCPTSEAITPPSTPPPQCLSSSSSSQYDLSDNNSTITFRRKPRPMSENLSDRKGSMHMPNSDTDDERYHISRRGRFVITSEVAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2Y6</accession>
    <name>A0A8H7Q2Y6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_000895</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2Y6"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="2"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="147"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="8"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="117"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2184982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="329" mass="34512" checksum="47E43100FB04A04E" modified="2022-01-19" version="1">MVKVTVCGAAGGIGQPLSLLLKQSANITHLSLFDIVNTPGVAADLSHINTVSKVTGHVGNEQMEEALKDSTIVVIPAGVPRKPGMTRDDLFKINAGIIRDLAVGVAKHAPKAFVLVISNPVNSTVPIVTEVFKKHGIYDPKRIFGVTTLDIVRASTFVSELIGTDPAQLKVPVVGGHSGVTILPLLSQVSGTEKLSQEQVEQVTNRIQFGGDEVVKAKAGTGSATLSMAFAGARFTLAVLDAIQGKTGVVECTYVNLESDPEGGKAIKQVVGDDVTYFSAQVELGKDGVSKILSVGKLSDYEKKLFEAAVPELKGNIVKGASFITDAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3K2</accession>
    <name>A0A8H7Q3K2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_000813</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3K2"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000159">
        <property type="entry name" value="Casein kinase I hhp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="9"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="299"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="423"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="490"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="439"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2184900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="530" mass="60764" checksum="0D9508A776D75BAB" modified="2022-01-19" version="1">MEIRVGNKYKLGRKIGAGSFGEIYLGTNTTNGEDVAIKLESVRAAHPQLEYEARVYKTLAGGVGIPFIRWFGRESDHNVMVMDLLGPSMEDLFNFCKRRFSLKTVLLLADQLLSRVEYCHSKGFIHRDIKPDNFLMGVGKRGNQVNMIDFGLAKRYRDPKTNAHIPYKENKNLTGTPRYASVNTHLGIEQSRRDDLESLGYILIYFCRGSLPWQGIRAKTKKEKYDKIMEKKMTTPSEQLCRGLHPEFALYLNYIRSLRFDDKPDYSYLRKLFRDLFVREGFQYDYVFDWTIKKMQEKKQTQGHLETNSSLGLDPMLSSMAALPPSHESSPLPLQQPPPRRTMIPPVLPSTATAHRVQPYRTLEPKTPEQSRQLDDVMLQYQQQQQKLLQQQHQTIAGMHHHRQQPQQVPSSSHDFNIISGYGYSSSPSARAMREEKPSSSSRVLRSQAKTANMSSTSNLVPQSTQQQFMTPPSYHDGISSYLQEAAAVDPNNNNWGTTNDHQNRTLPPVPTTSRSYHMMASSQRQYEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3Q4</accession>
    <name>A0A8H7Q3Q4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_000888</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3Q4"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07722">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000017">
        <property type="entry name" value="Lactamase beta 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047921">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF0">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="WHD_BLACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="33"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2184975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="309" mass="34839" checksum="599194CCF51CD6CD" modified="2022-01-19" version="1">MTEALLELPVFSKLSQRVWRVLGFNPGKFTLQGTNTYLIGTGVRKLLLDCGEGKEEYLPCLKKSLEDLEGAYISDIIISHTHYDHWGGLPSILSSGLNQSSSPIRVHKFMPNVMETTEFSSAHQIPEDIRITPLENNHKFQVEGATLQVIHTPGHTKDHCTFFLEEEGSIFTADCILGQGTAVFEDLKDYIDGLKRLLDYEPKRLYPGHGPVIEEGKTKILEYIKHRQDREAQIVQVLQTRQSATPMDIVQVIYKDYPESLHGPAAHSVELHLTKLLKEGRATTVSADPQDLVARLTQQQWSLKKEPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3V3</accession>
    <name>A0A8H7Q3V3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_000473</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the activator 1 small subunits family. CTF18 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3V3"/>
    <dbReference type="OrthoDB" id="2195431at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053016">
        <property type="entry name" value="CTF18-RFC_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46765">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46765:SF1">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="292"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2184564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="893" mass="101363" checksum="C7BE8000589253D7" modified="2022-01-19" version="1">MELDDYDLAFGQDNGQSDHDEEEPLFLNSLNTNLLNVANESMLSKKRKHVQEDPASSDEKENRASAFDDIFANALTLDGTNEQQLVSSSLQYSTVTEPKDYSQPPSTGAFITATTSNGEKLYFPKTTRQAKKAPQSLFVKEHMAHSTLLAKPIWKMLEEMELEAVNKLRAFEIEEKEHDDRLFDEAMKSPPKKRKKDKKQNIYKRVDHSALWVDKYRPASFVDLLGDQRVNRDVLRWVKQWDYCVFGKEPPTDWLKEKMMRQNKDMKQDSTPGKFNNYRFDQMQQDPLKRPEKRIILLSGPPGYGKTTLAHVIANQAGYNIIEVNASDDRTGEVVKSKIKAALEMQAIVNDSQSTANKDGKQTFTQKPNLLIIDEIDGVSSGGGNDSFIKVLVNLVTAEDGSSFAKNQRGQCFLTLPHRAIDEAKHGLLGGKKTQNQKPLLRPIICICNDPYAAVLRPLRQIAHNITFRKVPALTIAKRLHTICEVEGLTSDIRSLSALCEMTDGDIRSCLNTLQFIRGKSTRFSKDMIEHTPLGRKDVGKNLHSVWSDIFNASSAKKKRAFGSNQHNDNDNSYVSRLAEDAMTNGEFERLMQGCFESYPKMKFHDVAGQKIVSNFDWLYFYDLVNHKSNVLHQGGLYGYLPYPLVNFHRNFAGTVAQEHKVEYPKLDYEHFLAKKSFANLSDLLISGMSTLQRRMITKEKLITELMTLLLRIISPQLRPINQQLIKPAEKAILSRLVDIMIDFGLTFVQEKVDDGRFVYRLEPPVEQLILFSSTSASSKLAGQYSIRQLISHEIEVELLRRHEHAADKMAATNAKDSKKTAAVTAKESVKPPQQIPAEKLATDFFGRVVTKTTEMDVDGVTAGSFQRAKIWYRYHEGFSNAVRQPLQVKHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4S8</accession>
    <name>A0A8H7Q4S8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4S8"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF3">
        <property type="entry name" value="PROTEIN HU-LI TAI SHAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="54"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="288" mass="32019" checksum="B418AA69CA790CC0" modified="2022-01-19" version="1">MASRGSVFLRSNRKIILTGSETEEEAIAAAKAPIQIPRFPALKDVHEQRVHMKQKLAAGFRLFAKFGWDEGVAGHMTFRDPEYPDLYWVNYFGQSFSQIRASDLVLCDHSGAIVRGTKTVNKAAFVIHSAIHEGRPDAVCAVHTHSMYGKSFSALGRKLQPITQDSCAFYEDHGLYDDFGGVVYTAEEGEHLKTALGQNKALILRNHGLLTVGQTVDAAIWYFISMERCCKSELIAAAACPNGFDDLKLISHEVALGTRESVGDRQAAHFQFQPMYEQIVKEQPDLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q551</accession>
    <name>A0A8H7Q551_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q551"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14297">
        <property type="entry name" value="UBA2_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="363"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2185725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="407" mass="44674" checksum="56C3810A883B46AE" modified="2022-01-19" version="1">MDTVSVAHSWSRVDDMTDYGTNAIVRGHENESYAAVLDIPIMASPLYQMPQAVSLGNRLAIIPENLNNLLLYPFTLEEEVLEGIKEFKVLESARYEELERKYQQYVEDKIHRQKVAARKIAPGFLDTDTKILTPKPLNNTIPNGRDLDNLPLQNTEFSHNSSRHNRSLSAEIPLDRLTVSESSGVKPSTSISSGIGNKKPSNINYLEFEQGLAPLDPWDTPESDLDALHEIWQGGNSKSDYRRRTMTDTTGGVARGYTPYHAPPPSVQGHPQVRVYQPQQSLPLPQKQVPYSSSPHYPIGRPASGTSSPVPHQYPPKAASPAPAPAPAPAPPARPPKAFEKTSSGPPPPPPPVPAAHTENIHANDSNNGLIKELVDMGFSRDQAQVALEKNDNDISKATNFLLDSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5H0</accession>
    <name>A0A8H7Q5H0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5H0"/>
    <dbReference type="OrthoDB" id="2326446at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43072:SF60">
        <property type="entry name" value="L-2,4-DIAMINOBUTYRIC ACID ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43072">
        <property type="entry name" value="N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="67"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2186243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="229" mass="26194" checksum="A57DE3775C881B78" modified="2022-01-19" version="1">MLFLSSSSSLHVAKVRNKGGLISNHARTYMSHYFVLLDTEVLSFSMSPPVEKDLEYLELPNGTKLFARVPAGDEDKAIVRQFRVECGWDLDKVDDWFRLTDEGYRLQYLFCNDEGTAVATIALDLEDFHYKDPSVASFSSKTGCVASLYITQAMRKQGVARQAILYLETQAKLHGVEWITMNTMVTNNVSRSLFSSLGYTEYKTEPRYIHTDFQDKILAVFYHKQLIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5Q7</accession>
    <name>A0A8H7Q5Q7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5Q7"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF260">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2186378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="441" mass="49494" checksum="CDCA2625ABF191B0" modified="2022-01-19" version="1">MTIDFRGLYTPSTNSYWLDGAPWQQPNNEPLPKSADVVVVGAGMSGLSTAYWLKHYNPKLKVVVTEARGISSGATGRNGGICLPGLNDSFQETIDQFGYEPAKRLLDFDYLTVNEMKSFVQHHCDTDKGFFDPEMTFLKEGGLILWSTPQQRDDGIKDADAFIAAGLAHDVTKLDREAVKAITGSDAFYGGLQIKTTAVLWAAKFVFSLARQVQDWCHIATFCPVEEVTEIGDNIKVQTSRGAIQCSKVVYATNAWTSSILPEFKKHVIPVRNQVLQFRSPEHVKWDYCLSSNDGYEYMSQRPNGDIVIGGMRNLVDGQEVDQPDDSTLDDKIGKALREFLPKHFPQFKESDIKVDHEWSGIMGFNMYDRLPFVGPLKNIPKRNEGEYACFGFTGHGMPRTFMAGKAVAGMVTDQALPDWFPTECLPDHPRRRQLWNKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6C1</accession>
    <name>A0A8H7Q6C1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">INT43_002322</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6C1"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000001">
        <property type="entry name" value="ADP,ATP carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="8"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="113"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="212"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2185884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="304" mass="33674" checksum="949EBD4903791729" modified="2022-01-19" version="1">MSTDSKQNKFVMDFLAGGVSAAVSKTAAAPIERVKLLVQNQDEMIKQGRLSHPYKGIGDCFSRTIKDEGMYSMWRGNLANVIRYFPTQALNFAFKDKFKRMFNKDKNRDGYWQWFAGNLASGGAAGASSLFFVYSLDYARTRLANDAKSAKKGGERQFNGLIDVYRKTLKTDGLAGLYRGFNISCVGIIVYRGLYFGMYDSLKPALPVQYKDNFLVNFALGWAVTTGAGLASYPIDTVRRRMMMTSGAAVKYDSSLHCFREVVKNEGTKSLFKGAGANILRAIAGAGVLSGYDQLQILMFGTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6J8</accession>
    <name>A0A8H7Q6J8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6J8"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039195">
        <property type="entry name" value="ANKRD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24192">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24192:SF3">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2186019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="246" mass="27333" checksum="6CA9360EDFDB5516" modified="2022-01-19" version="1">MITDEREESLREVSALGNIKAVNHYIHAGVNVNAANKMNNWTPLHWATHRGHVPVVTALLANGASPLLLTNKQQTAADLAKTDEIRALFPQGAFSDAKPEGDLPIVPTYMKEPDLDKSWNLPDEFAESRIRRIMESQKSLKTEVPSPVAEKREAVPAESSLPEKEILVYRDNRTDANLLGAVFIDTQSTIEDVIKQVEDELDDLPSSFTISRHNGQVAIPIGKKQYAKKTLVHFRGDQDAIIVLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6P5</accession>
    <name>A0A8H7Q6P5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_002753</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6P5"/>
    <dbReference type="OrthoDB" id="5599552at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF18">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="6">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="98"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="213"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="252"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="487"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2186315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="538" mass="60249" checksum="B92D7F5F4C021AD4" modified="2022-01-19" version="1">MYASLMAADIDEELHLLRDGKTRSTTGSVVSSLYHLKDIDNADAGFFVFPDLSVRMEGNYRLKLSLFEIIGFPGMEESTFLSRSFADQGLKLRIRKEIRVRRKQSKRKESQSDSSGRQHISNKVYSKRARKGSFNHEDDSDNWSDGENDSSHMHSNISSGVSSADTWHNNSNDMNQPSKILKSDSYSSSPNVEPENIDRLAVNSRQTPIILGSEMVLPPTNRSYPTPYPPYSNNNVAQSKSMSSSVARNRPGAPGYQHQQQTQPGAPQPQWIMSPSEQPPQSSENWYHRLSEDSNVNQRENPSSDSGGDSPSTQMTNVFYPASSGSIGLNQPMDATYGARRAGPAGAARYNNYQLPPSGRSSAPETYAMPGPSTIRGVSGSPYTRYSPQQQSSPRPQAERSRHSAESYYSNIKPSKDQEHMMYREPYSMSRRQGSMSHPTQDGTVAPHEEQVSPPAPHQHAVNMPGGNLEWYDESGRYPHQGRPAGHPVQSKQGQQPQPQQQPQQYHRPPQQPQQEQHQSSMYPVSEARMYYSDVPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7B3</accession>
    <name>A0A8H7U7B3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_005141</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7B3"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2173721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="658" mass="74157" checksum="3CFA3951A1C5ADB2" modified="2022-01-19" version="1">MTKNLSINTRKSIGCYWIGKTLGHGSSACNELINSFIYFSLLPLPYIQKCIYTGCVKLGFHKKTMEKVAIKIISKAYLQSSEILARATKREMAILQLVRHGNIVRYIDAIDEPHIPYVYIIMEYIEGCELFDYLLESKRLKEAEARNIFWQVCVAVDWCHQRNICHRDLKPENILLSGSKKEVKIVDFGMASLQPQTSLLKTSCGSPHYACPEIVTGKQYDGRLADVWSCGVILFALLSGRLPFEDSNLRVLLQRIKSGQYVMSTYFSADARNLIKSMLETDPKRRIKMDDVIHHPWFTKETNYTLPANIPELPRQYNQSVELERHTLNIMKTLLDCSMSSTIISAICSNRPNMEQMLLSMLKKSTKNNVIGEPMTISKQALLECMDFKSPASALSSSSTLCDNTLSINKAFDVADKIVQSHSGTIEGHEDAISHCPHDISSASKPDGVSLKVKDNLNEEIRNCPMIHHFGLMAGCLKARPAQAKLSYASPRPVIAIDTIYDIQRWKSEQRRKESTHTGKRVSGWMRLSFWKQPKEKSSQCIIECSGQDEDEAVSKVVYTITNLMQGSFAFADEPHTNSIGKGQVQAFNKHIPVFVMFCLLAIRVQPLSANRRTVTLALSPINTDLNVLTEAANDIQRLLQQYDLDEAEALTANGWIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9L8</accession>
    <name>A0A8H7U9L8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9L8"/>
    <dbReference type="OrthoDB" id="548474at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038966">
        <property type="entry name" value="TMA17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422:SF1">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="136" mass="15050" checksum="1EB8FB5946079FD9" modified="2022-01-19" version="1">MNATQDDLDKLPTETILAEIGKLQNSIKHLVRSNTEMKEFDPELTDGDLHQAVQENEQVIARQDSQIDRLIETIRNRLGADAAREIESTVQEYRQKDLDLISGRAADAVTTHSADTTQDADAAADGNDQDTDGVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAB2</accession>
    <name>A0A8H7UAB2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_004871</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAB2"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000007">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000001">
        <property type="entry name" value="Oxysterol-binding OBPalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF102">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2172329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="46312" checksum="E30329E16EC62C14" modified="2022-01-19" version="1">MHKNDCAGDPDSTEVLEEGSRSILLSLASQLRKGMDLHRVTLPTFVLEPRSMLERITDFFSHSDYIIEASKQDDQVQRFISVVRYYLSGWHIKPKGVKKPYNPVLGEFYRCQYKYADNTEGYYVAEQVSHHPPISAYYYASPENGILIAGDIRPKSKFLGNSAATLMQGSSHIIFTNRHNERYDIVMPNMYARGILFGTMTLELGDASSIRCISSDLICELEFKTKGFFSGQWNSLVGKIKRESTGEVLFELSGQWSDEIYIKMNKASSKNTLFDVKESKIFPKTVAPESEQEPNESQRQWADLTAAIRKHDMDAATEAKTAVEDRQRHNAKIREDEGVEWRPRFFDAKNDDFVLVGTDRLDFSKPEDTKKQLHDFIFAKHEDAFTHRKADAVANNQATSTTTQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBQ0</accession>
    <name>A0A8H7UBQ0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_007689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBQ0"/>
    <dbReference type="OrthoDB" id="2373056at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2177035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="88" mass="10111" checksum="ABA4CE63931230B2" modified="2022-01-19" version="1">MFNRTPSAITLKPEDLEEFDQLEDQELKANITKGKGRVTPQSMPHEEFVFMQPPTPNKKVRAFFDAKATTTKRNMTLNQRLGIEEFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UD28</accession>
    <name>A0A8H7UD28_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial proton/calcium exchanger protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Leucine zipper-EF-hand-containing transmembrane protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">INT43_008743</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LETM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UD28"/>
    <dbReference type="OrthoDB" id="275278at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059005">
        <property type="entry name" value="LETM1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26561">
        <property type="entry name" value="LETM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="22">
        <location>
            <begin position="221"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="621"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAG2181161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="693" mass="78735" checksum="5E98773DCF8B930C" modified="2022-01-19" version="1">MSLTLTARRLPHAISVRFVPSRYATVGATSMLYNTHRVTASNQLRYRMQAVSRFHSGSRGRQDIMRLPKELRIFRYAEQTAAKQIKEEKETMASRATMLAKEQVAAKNAAAAPAAVKQKKPIMQRIKEEAIHYWHGTKLLGLEIRISSKLTAKLLRGSKLTRREARQLRRTTSDLLRLVPFAVFLIVPFMELLLPVALKLFPNMLPSTFEDKFQEEEKKRKLLKVRLEMAKFLQETIAETGVPGSDDARAAKEFGDFFRKIRITGEQATTDDILKIAKRFEDELTLDNLSRPQLVSMCRYMGINAFGTDNFLRYQIRNRMTKIKADDRVIQNEGIDSLTIQELSNACAARGIRTIGTSPARLRDELAQWLDLHVTHQVPSTLLILSRAFSFTDRGLISTQEALQATLSSLPDNLVNEAELQVLESEGATTYKQKLEVLEQQQELIEDESEQEEKEALARKEAKEAEEAQKQLLAEQEAQQKAELGDKFLTDEQIAQKEKDIEEVRLSEEQLQELRNALAILCTKAGILEEREQLNEIKEDHEDYKEDIEELQEATKRQADKVTTRLGKRLEKMLGKLDKELDAFEKAQHHSTGFPRVNLTQSGQISTADLEEALRVIRHAPDSDVIKKVVKQMDLDADGLIFLEHVTEIAKQVPEGLGVVIENITDKERDGRLRSDNVLKTGLVGGSDDQSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UD49</accession>
    <name>A0A8H7UD49_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_001185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UD49"/>
    <dbReference type="OrthoDB" id="2393977at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2175538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="110" mass="13180" checksum="99E81179FCB77C70" modified="2022-01-19" version="1">MDFIDAHANNMKAAKGFRRATVYVCDPDEDWGQDKPDKLHQNFRVNYEVEDEESLHKWIETEEPKITKDLEKLRKQDNEDDSINVIARQVFNPLSQYRINKKQKRTRSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UE21</accession>
    <name>A0A8H7UE21_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_003415</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-12 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UE21"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044986">
        <property type="entry name" value="KIF15/KIN-12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37739">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIN-12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37739:SF8">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIN-12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="22"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2178162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="370" mass="41633" checksum="DB47D472FCBBE40C" modified="2022-01-19" version="1">MSLLILVSSAQFAFYDHKRDSNVQVFVRIRPPLSEASDDSIVQMVSPTSILLSGPRSEMFTYDQVGGPHTTQDQMFEWVGKPILSQYGIDVASSNVLIELHISDNLHVNRYTMQGRSSSAAANARYEGVILRICSILSNWICVVFDLIEESEKQTPESQYICRGSYIEIYNEYVYDLLDPLQTQRAVREDIKRGVYVDGVTQELIPDHHAALKLFQRGIANRHVSETAMNRESSRSHAVFTLTIQSKVLRDGTFHLRESKLNMVDLAGSERQRDTRSDNARLKEAANINKSLLCLGGVINALSEIANGTQRHVHYRDSKLTFLLRDSLGGNSVTYIIANIDGSQRAFQETLSTLRFAQRAKMIKNTVGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UE29</accession>
    <name>A0A8H7UE29_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_007198</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UE29"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034412525" description="peptidylprolyl isomerase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="9">
        <location>
            <begin position="49"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2182271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="201" mass="22849" checksum="75C8997BAF005500" modified="2022-01-19" version="1">MKFWSSLLLLATLLATTVFAQRHPVEPPTTLRLAVLRKSKSCPAKASKGSDVTLHYRAWRWNEEEPFESTYDGKPMQFKTNDKKVIPGLEMGIENMCVGEVRRLLIPSSLAYGEMGIPNLIEPNTNLVYEVELVKAMTTWTNPWFYAGLFGLGLIYLIFERFSKADDQNKAARFVEKKEEAKQKLEASTENVAEPSDKKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UF02</accession>
    <name>A0A8H7UF02_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_006296</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UF02"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF55">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="497"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="567"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2183291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="606" mass="69063" checksum="E600DC12109A2287" modified="2022-01-19" version="1" fragment="single">LVICTLLVAYSEAGGLFSTSPTILRKGDSIPLYLNKIFSFKTQLPYAYDELSFICPTSTERSRPWLNLGQVMRGDRIVESDYKLIVGQDASCRVLCDKPLSVEEAMQAKKLILQDYQVEWILEDMPSSTAFYTSEVKTKRYRTGFPLGQVINGRTYINNHVALHIMYDNVDQDHIRIVGFEVYPESYRADECEPSTIDFERQEVSERRSSVRYRYSVNWQLNTGISWEQRWDMYLLASDNSLHWYAIINSLVIVVFMTAITAVILMKTIRKDTKDDDKLFSSNSDDALGWKLVNKDVFRRPTYGGLFAPLVGTGVQLLVTFVPTLQLVYLGILNRTHRGGMVSFAITLYILAGSLAGYSSARVYKIFKGRSWQLNAVLTAILLPAVLFLAATITNLFIWTKQSSWAMPFTTWLTLVVLWIVISLPLVLIGAYIGERQARIEQPVRVSPVPRSIPYKPWYMSNWISMAAGGALPFAVVFMEVHFLLKSIWQGQMYGSFFFLEIVTLLLVITVVEVTIALVYFQLCSEDYNWWWRSFMIAASPALYVFYYAIAYWLIVLNIDGFVAGLAYVVNVFLASLAFGVCTGTIGFISTYIFVRRLYSSLKVMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UF99</accession>
    <name>A0A8H7UF99_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Myb-like, SWIRM and MPN domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_006614</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UF99"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIRM" evidence="3">
        <location>
            <begin position="20"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="MPN" evidence="2">
        <location>
            <begin position="224"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2183606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="45124" checksum="72DA3A4AE913C79A" modified="2022-01-19" version="1" fragment="single">RFQHRTKGRIAFNYLNVSYYDVLTLSQQFHPHHANEDEIKNNREWFIGKASKTEERYLKIRNTILAAWRRCRPRYLTKTSARNGLKDCGDVNAIGRVHTYLESIGAINVNCTTNAPRPKRPAASRVEYFSDEDDTNVGQVADWLMDYEGPRKRKVRDEKGRWVDPKDLEGRVIEHGVQVEEVKSRPKRTIKRPKHLQNDDFRHGYDPFRLVPLEHYDDDPPFHVYISSDAMIVMDFHSYLAHTEIIGLLGGKFDAEKKRLEIQCTFPCKSTSTGIQCEMDPESEMKAREVFAEMGMTVVGWYHSHPTFEPNPSVRDIENQSSYQSLFRHDSGLEPFIGVIVSPYDYTPVTNISKIQYLSIGSGWDSSGSFSKFRIRRVRERYAKSNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFM6</accession>
    <name>A0A8H7UFM6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_003673</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endomembrane system</location>
            <topology evidence="4">Lipid-anchor</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFM6"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="84"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2179887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="114" mass="12618" checksum="A82BB79975A43E44" modified="2022-01-19" version="1">MSFFSDVRTWFSNIEQHASEGVNKILIGNKCDMTDKKVVSTEQGQNLANEMGIGFKETSAKSNIGVEDAFFELARDIKKRLIDTQQAQQTRKQEEVRLDPGSNKPNSSSAGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UG41</accession>
    <name>A0A8H7UG41_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UG41"/>
    <dbReference type="OrthoDB" id="2409403at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="557" mass="61960" checksum="18409541FF1B944F" modified="2022-01-19" version="1">MSVSRTRSKSSKGTSGKKKSEEQAMVEAQASNAVVAVGQKAEKQTRQTNEDIWDVGNVYNQDNMKPKKPIVTYSKRKYKPRPELGSLLTNIYTKGQPQKQSSKSHAADDSTSSQKPIAELQTKIDPLSEQHHDSCLTDKNGLSAINRQKEVQEPPQHEINGLIAKEHEADKNGLPLDHTAVIKSRSATGKQKDVNGNKSKPVKKSLSLSRTRKQKQEKMQQEQTGTASTLAAVQPPSPVNTQTDNVAQSIEIEDITAKEPKHSEPKLLRLDYRPAQYDQTSENDDLEISLDHLNISPIGNVSTEARKHKRIASSTPLSSRIQQHMHASKPSLSFAESLKKADVEIESRAEVLGSGISRKQPAELETIQDSKSSPPPNQFNLTELHQERAISSDDQRLAPASISDTEFSPIPINNAVIHLQNHRKAIEASIAEPTVYDLGNSQIWSPPRSPSIEAARRESLRSEGQNNIPEGIFEWFGSNVAHQDNSTSEQQPLLDEDLEQFLTPDQLGMTVEQFMRSIYEEKIEQVRKEGQQRIDRLDGAIARVRAKLLAELVECDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGM9</accession>
    <name>A0A8H7UGM9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TFIIB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_000989</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGM9"/>
    <dbReference type="OrthoDB" id="2382064at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2185076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="53998" checksum="164F606AFCF96001" modified="2022-01-19" version="1">MSEVNACPSCGADASHRKTDDEQPSLIFCEQCGYVLQDSHFMLDRHIPRNPDPRPRVQFKRPRSMEKHITNTLKEIFRLAVTYHLTDEEIYAAKRYLSKYYETCRPPSYDITATALVYLVRKQSRRPIGLRTFAANAGIPLHQIGREYLKMVKVLHPNIPEDSWEPAIDLAGLAAKAYKYLGPLRNKEPAFSYQELLKLARRILDTAVASSYNTGRAVNSFVVACIVLASDVLSDTRVTGKRRRERLNDIGALTLTAGQSIEKRYTELGKLFRQKADALPWKVSSGNKCTDIVPVLLDILEFEESLQSSVTTAKVEEMKKSRQASLDSNFEGASSEMSNQPSGDSELATAISGPPSFLRAEIARKQTMAQLEKARKFDESLNENEEDPEVLQMIYLQDNGYSDEEIYLMTEKQRNALEDSLRFREQHFISQRDDLDDPHLDDEDLSFEEQKMYIIAPVSKRSIIGTKRTRAAINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGW6</accession>
    <name>A0A8H7UGW6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-and gamma-adaptin-binding protein p34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_008835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGW6"/>
    <dbReference type="OrthoDB" id="10261384at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019341">
        <property type="entry name" value="Alpha/Gamma-adaptin-bd_p34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14659">
        <property type="entry name" value="ALPHA- AND GAMMA-ADAPTIN-BINDING PROTEIN P34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14659:SF1">
        <property type="entry name" value="ALPHA- AND GAMMA-ADAPTIN-BINDING PROTEIN P34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10199">
        <property type="entry name" value="Adaptin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2181252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27933" checksum="EA126637FB04CBF1" modified="2022-01-19" version="1">MIPWDIDTKYYTASVDFWLDHIESDAAEAVKAFTDDEAGISEVVDAVILVFRKDEPESFNDIKIWSSFVEKCDLSIRVVLGTCGDLPADYVDTVDEWCSENLFVYVDADEKMDNSEENPMDKTGIPLLLETLEANMWDGLILKSSQAQSSNTGRGYIRCHYDCIQVAHCVLIHYYTDLPSEADIQNMRKQLFGALDDPNDGLDQAFAQIQSLRDMGTTLPDSERRKLAAQVALSFAAQFNDTDKDIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHD4</accession>
    <name>A0A8H7UHD4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHD4"/>
    <dbReference type="OrthoDB" id="2264036at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="238" mass="25923" checksum="18AE584A6496664B" modified="2022-01-19" version="1">MSAQPNTKPVQEPAGHPLASNNQTPQVQGQDYRQSEQVQAEGQPRVDQPTPQAQQQGEQFQAGGQPRVDPATPQAQSMEVNKQTPQMQGQEHRQSEQVQAEGQPRVDQAAPQAQSMEVNKQTPQMQGQEHRQSEQVQAEGQPRVDQPEPQTQQHSEQQAVPAQGETQNQQEPQGENTGAKANEDENNDDGETGENGEPKQPAKNTGGTKDHVKEQPDTGELGGLTGKQPVGKIDLHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHT8</accession>
    <name>A0A8H7UHT8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHT8"/>
    <dbReference type="OrthoDB" id="5565730at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 213 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="252" mass="27745" checksum="D7AF9F85B54DF3F3" modified="2022-01-19" version="1">MVLNEDSISNIVTGTSIAALFGAGTGSAMAVLRNASVKQFATSTAINCGVFGVTFFSVRESYLAYQRSKNPQYGLKISQTQDADALFSSAMAGATTGGLLASAARIYSDFQLGGPRGLIPGFFIFGALCTTGQLLYTAGYHWRQSIILRSQGSNNESVGSPIQVSTSLQRNINIPAHSTVFDQDETFKNQTAQDREWNRNTDKKSLWDWFEVPKWSPIRKLTDEEYKAILDAKLRELEAEMEEIDRELVNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIK6</accession>
    <name>A0A8H7UIK6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_008715</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIK6"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2181133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="332" mass="37482" checksum="AE92602A840E1F34" modified="2022-01-19" version="1">MSQRRSAAKSNGANSMNSNGSHSNGDNASVLNGVDSKTPLLTRAQKIRTVSWKELPEWLQDNVYITGGYRPQLDSYWECIKSVSYLHNEFVNIWSHALGFLLFCILGTYFVWKDVLDPIAETRTIWDVIFFYTFIAGALSCLGLSSSYHCVSCHSEPTAAFWNRCDYLGIITLILGSYYPAVYYGFYCHPYLQIFYMSAISIIGFATGCVTMMKHFRTPTYRWMRTSLFLAMGLSGIIPIGHGVITFGLRMALSSISLGHMIAMGAFYVVGALIYGNRIPERWYPGKFNIWFASHQIFHVFVVIAAITHYIGVSRAVAFWHDPNNAGICEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIX9</accession>
    <name>A0A8H7UIX9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Malate synthase</fullName>
            <ecNumber evidence="2 8">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_000748</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the malate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="2 8"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIX9"/>
    <dbReference type="OrthoDB" id="186072at2759"/>
    <dbReference type="UniPathway" id="UPA00703">
        <property type="reaction ID" value="UER00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1220.12:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.360:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="entry name" value="Malate synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="entry name" value="Malate synthase, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048355">
        <property type="entry name" value="MS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048356">
        <property type="entry name" value="MS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902:SF1">
        <property type="entry name" value="MALATE SYNTHASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20659">
        <property type="entry name" value="MS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20656">
        <property type="entry name" value="MS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="MS_TIM-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001363">
        <property type="entry name" value="Malate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="Malate synthase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Malate synthase N-terminal" evidence="10">
        <location>
            <begin position="5"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase TIM barrel" evidence="9">
        <location>
            <begin position="154"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase C-terminal" evidence="11">
        <location>
            <begin position="406"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001363-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2184835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="533" mass="60643" checksum="B288E9712653B6D6" modified="2022-01-19" version="1">MATLNVSNHKSDILSPEVLRFLEVLHKTFESRRQDLLTARIARQKALDNGQLPDFLEDTAYIRNDDTWKAAPIGPGLQDRRIEITGPVDRKLVINALNSDSRIFMADFEDSTAPTWDNIMYGQINLRDAVRNQIEFVNPNGKTYALTEKGKETVLMVRPRGWHLDEKHVSVGGRPMSGAIFDFGVFFYHNAKVLIEKGHGPYFYLPKMESHLEARLWNDIFNVAQDMLNIPRGTIRATVLIETILAAFEMDEIIYELRDHSAGLNVGRWDYIFSFIKKLKAHKQYVLPDRSHVTMESPFMDAYVRLLIKTCHKRGVHAMGGMSAVLPIKNDDEANKVAMEKVRQDKLREVKAGLDGTWVAHPDLIPIARQVFDEYMPQPNQIHVRRDDVHVTAQDLLDINVTGDVSEHGIRDDIAVALAYMESWLNGKGCLPIHNLMEDAATAEISRAQLWQWVKHSAQTIEGRSVTASWLLELLAEETHTAKASSNRSNDNKFDLASQYLATQITGEENKFDEFMTSLMLDDIVAVQEKHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIY5</accession>
    <name>A0A8H7UIY5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_006463</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIY5"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="577"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="645"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="723"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2183457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="781" mass="88188" checksum="80AFE7D03C3DB5B2" modified="2022-01-19" version="1">MSSHDINGGDVEDAPAYERRYTNDPVEKIESQSFNDEKGDPYINELGNPDVDHVDITSDGEEKEIGTEERGGIFGYLDLISETIPELDDPNLHLFTFRTVFLGLGLGCFAAVLQEIYYFKPQVIVISPLFIQIIGYVLGTGMARVIPTSRFFNPAPFNIKEHVLISITGTSAATAALATELLAVMDLFYNKKVQVGVAIFTVLSSQLLGYGFAGCFRSFLVYPRHTYFPTVFPSITLYDSLHNGNVLTSKRLKVFWGVFVGIFIWEWFPEYIFPWLNAVSFFCLGKQDSQVFTNIFGGSSNNEGLGMLSFCFDWNYIGLVFSPMYLPLTTQLNMVLGYLGCYIMFTWVYYTNKWNAQAFPFLSQELYLLTEGSSYWNYTIYDQTAILDENYVVVPELLQEYGLPWYSTTYVMYLTVANVSLTAAVTHIGLYHGKAIWNTFKSLWHGKNHQGKGDVHFEMMQKYKEVPLWWYLALLLVSFGVAMGMIYAGESTMPWWGLILAVILAFIVTGVNCLMTSTTGFTISTEAMIQLIGGYVMPGKPVANMWFTLYGYNTIGQATSMIVDLKIGHYMKIPPRALFSAQIAGTIIGGLLNYIMMLSIVENQREILLSPQGTNIWSGQNVQQFNSGAVTWGGLAHELFSPGKIYYPVAWSFLVGFLVPVPFYLLHRRFPKVGFNTINTAIVVWFFGDLCVGINSSITMALCLGMFFQFYMRKYRSRWFAKYQFIVSAALDSGTLFSIFVMTFAVFGAAGTTYPFPEWWGNPMADNQYPDHCYFDPRLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIZ5</accession>
    <name>A0A8H7UIZ5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="43547at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033228">
        <property type="entry name" value="SZT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14918">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN SZT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14918:SF3">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN SZT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1283"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2216"/>
            <end position="2291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2702"/>
            <end position="2737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2848"/>
            <end position="2895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1309"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1324"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2221"/>
            <end position="2231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2261"/>
            <end position="2274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2848"/>
            <end position="2874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2880"/>
            <end position="2895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="3630" mass="411445" checksum="2120AAB0A040B6CC" modified="2022-01-19" version="1">MDDSASMDRERTEFQLRPTNEALNDEKHEQVDVSGTQNTQIKPGPIAVPKIAEARVALVVTKNSELFSRNDPTQWLLRHMFQPLVVNEYDSVDVLYLSSSRRSMWQTLRQQSVPPTSAQTPTINNYWQTPITPSPAPTSPLVRSPTPTNTNETGTLARPQAKTFKKYLVTPQTNVLSISREYRYVFMIDLSSSLATVDGWTGRLLIDDAFETLSRCLAGVIKPYGFDNPTRSLGALIEPVIHVTVLAECSQFASNLNVIPILEEYPTLRVLLQSVIVTPQNSPQVLEKLKEGLKTFQNDLIAFRKSLSKRREKLGYELDVRGEREEEREDIAGGNEYDAATNVNTASEPQISSPERRKTLKGRRARSSSRISLRGIGTKTAIKAGAKHSRSVSVNNQRVPPSPLALEHAKHQIQPKQEAQEVWGVGKTGGNLSYLLHAGLFALGLLPQSARPGFVLITDGVIKSNVQDEAIIRQMRREDVNCSVIQVGAQHGFSPGCNFGLVADNEILRFLASATLGHFMYSEQCHETEQAETAAIDAQLDHAGPETEIRPPNIYHRMFLIRDICFGRTRTESQIITMEEGVDSQTNLNFPWDPRSTPPPVENHLLKYQEYPLPSDFSHIIAARVRQGFVVQSLNVEDHTTRSGEYALRKERIQIILLLQWQPNITVEYRIRASWFPAYIAQVETAGLTGPGGLGVLHGGIFARSKAPKAEIFIRAYGVFAHTLQNWDALHRRAQMMGLVTGGDGFGEYSASPLYSKVYKLKKFLLEIYRVDEVLKSFIGYNARYLSGSKPASDEEVEASVSRKEQNQRRYDSYVASLKEFWNHANGLDVRSLMFSCYDVACIDILISNLKPYSSLKLTMSYEDYIDHFEHNIQHTISRIKDYVDKQWATFTSDDEDVYVKVLQKSRKNPFQAGDDHLELGSYDWNREQGENLSLHNLQQVISFAELRLRRENGNSLSARLMFFNADVYARRRIVHELKEGLKKIRYDNEAWRSLSNRLDEPDPLYWQPDGRYLKVLQRPLSSLLMRDPAHLNSADRVPQYLTKFSPLYSQRQVAHKPWFISRPTWLTSEYIVPNYLRHITCKWQIDQVNAMANKENSSWRILDLAFQFICQSRLEQNFDMISSQNDSAHFYCEDKRYIGSETLSAQFFVSKDVHTGSITTEIWIEPTHQMEIDDHEFLSRSFVFASDKALLSRLVTFDKAHAIGHARTREQIELEPIKRPHESDGAYTDIVLSVSDLFDMTTVLQHSSFLIASFACPTFNNSTVNESDMVLTGSGSATPDVLLSPKLNSNSTDTHKPLAASRSARPVQKTSPSASPKLDTQNGGHPHPLSSGSSTEPKARQNELHENYKQALFDLSPNKQDYALLHYFVEQALSKITDGEVVMTGQIASDSFWKNLTQAMLATDEHSIRNSALQHISDIRQLRCFIKIFDSKSFIVIIFPMLSATIRGMKARRLASRQYNPADATAGGFLTLLEDMPIGGNAEAWDIQSLGVIMFECRRLKALDEGFVSRAEVYSNQELSNHLLNGSISIRRLPHLIEENDGLGATLRPEMFEGSFQQTQSNVGLSERTLRLTQDIVKVYERNFVKSIYVCLLQGKSVEPNDFSKLLEICDESSMDIDVTGYVNVQTLRRNNHHIKQVFLNWSLCLKNLLLIISTSMDEMDDVHQRFLTILGHYFEPVNTTNGSRPSMYCYRPPFARFGYRNSSNDEKVRNLLDLSAYFQNPLLIRLECTFSKPGLDGKDKVDVTVPITHLPSSYDVKTGDGKVYTVQPDGIGNEQSPVASTDGTSATLHIICLTLPWMQEDSDDHDWNHVSDYITDGPITPQPSMIDAMRSKPTCFDSLSRDKQEALAETEARLLWLLTEEIMHGLLRSGPVNQPVLDYIESQLKKKNPFVDFPTSMLVPLSFVKRPRLGKRIFLDQLAKDRHSPYPLSRVGDYFYVNEDIKPSDLKDFLITEPTTPITPLTDSDLTTQGLMIRGLDQDQADAEENGGDEFCQGLGISIIAPTEQKDLDDEPSEAYQVSHRQLYWLLLIPQPHSVQIYFYSKSFQSVNRSEIIKHTKIKISEVLERTNRLILLHDLEETKLCSKFLMAPDENESQWHYSSDEMVEDEDGHTGAPRELVDILATSEVSELPSKKFRPGQFECPMVFFKQFPLHWRLQPKSALNILANDVLRPFAVKNRCNMFVIPILPKNDSIVYCKLSEVVVTISVPEVDLAAEENPRKTSSPFGSSLTMPADALASPKSSPHYKLHTNSQQHSQSSSPKESGGSNAQSPQHSPKFGGNLSPGYHKGAQRTMESRELLLEVYGIEASSWIEGELVDMLENRLSSQITLKEVQQFLTRNPNSRLSPADIDFILPVDKPATCKKTLRVPTLIEDPYCFMQFIKQNVLASSLRSLTGPEVFHATKRHLRSMFGFNYSEYNSNSGNRQVSPSDTCFYYSCLNRSLATASALEMKVGQGIAGVCFILLDKSGYPCLEIPASIEPTMAYKDLDNLAVEECLNDDFMEREDKPNHYQIMIEIWHVGQVDPEPLMKHLWQCYRQSICEYLIETILVSDRSSLMTSSYAKDATPHDEYQRRSSASSAMHSHLLDPLFTILKKAGAWETQAVSEMCKAIDIPPWGLRDVIRQIQADLMDVDKSCKPIVARADTMVGYHQWPNFQILNPEETDFIQDSADINQNGYYIILSGHREFQRYFESLDGRSNSNKADNCKSFGKSSIPEQKTGMPDKQVRKGSNFGPKTKYSKQRLQAEAKSMAGVSKSSSDGIVRYKTTLNETRERHHFFLMSIDSEHIATYTYNWTDAYIDKIFGRVYRSIHRQQHRSTVLNNIVHQKMGLFHHANSIPDAMQQLSSGASYKTTTQATPPAISTSSSRPGFSSLLQGPFKPLHSPGPSASSSSQRLPLIDTSSRSVIPTLASPSPVVTSQTITPTMTFNLLQELVMYPVQSKSTGSLQRPQLVSDHRTIGSFNAQEDKSLKKTEDLFYTAARNAAINDVLKDSTTEPSIDQPFSNHADLLIRHGSPFLNSYLRRTSLQTAHEKAFSVYTKWAKKYQDPRFTRDETQRERMPYRELSTILRSSRLLHFCRTPLLFSEIGVSEQKAESRIFTDPRISASSVDSTLLWYSNLVTTFMREYAAYLESIGMQIIVFGPSPNEEISDSEPYISKFKIADDLSVECPVVYLLKVFEGGTIMCEVRITDMFVSVTLYTLHRRYGRMTYTPWTYEKDEARRFSFRTFTEECDNFKQLIHVNSFVYDFHLRYITRALGKSGLVPLSLNLVHVIRHFASLHTHSAAYSRNRIVTGLYECDGDSSVMDNLFGTISRNAERYGLQALFLGSKVSACFLQSDSLTFEKINSKEKKNRPYYRYTLLLCPPPESFYMAPSFDGMTPASSTRLTTDSTGESSDRVILQYYIIASYSKATYSQEATSRFWGHVGNGSPLNPMDEIMAPETYALGDVIQHAKKKIDSLIAQAISFTGRDYDWNRMFYGALRNSRVATQIQAHTPDELAESQQEVTAEEAVKLVNRFEKQNVLEVDPNFGKFFQPCFNWPHILGFLHNVYPISGELLVNGDYHLFLFHPQATYDYVMHIRLAKEITIEMVYREKSTDKALGEMEKQLIADVAKSIGYYMIQHVKSSRRIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJR0</accession>
    <name>A0A8H7UJR0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_007263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJR0"/>
    <dbReference type="OrthoDB" id="59470at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47703">
        <property type="entry name" value="D-AMINOACID AMINOTRANSFERASE-LIKE PLP-DEPENDENT ENZYMES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47703:SF2">
        <property type="entry name" value="D-AMINOACID AMINOTRANSFERASE-LIKE PLP-DEPENDENT ENZYMES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2182333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="326" mass="37161" checksum="43C6164049A885B6" modified="2022-01-19" version="1">MQKVVSLVIALSYTHISCYQLTHLCSCCHCAVVIEQENPLAPPSEARYNYEIGCKEPNEFFLSYPRAAYTGARTIQRHSIVQLGQHIFRTSNSLRLMTFSEKEDQLEPDYVTKDLSIFRDEKQFEVRLLPLLKAGLQKYYAEVEEDHDKTHETKVSFLCGYSFEPHQVHFAAQFAPLRSPPRKRVAVDVEGSPREHAAAKDSKWVRDRLTLEKHKLPNANEVLLTDHSGNIYEGMASNFFAIVNENGSPTLVTAGLEHVLLGTIMKIVLRVCEKRKIPVKWEFPSLQDAVDGKWEGCFLSSTSRLVLPIETIQLKDGRYVLCEAIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKE7</accession>
    <name>A0A8H7UKE7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKE7"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2182139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="50686" checksum="9C59E396885D3644" modified="2022-01-19" version="1">MKVSHHNWSLPELVLDTIVHHLDTRKDVIAFSAVQRSWHLAAIRKLYDRLVVDVPQPIFEHRRAFLGRLENIMRIHKRGNYVDELVLKMKILQDEEAFVKPMVESSSSSTTTTKSSSRPTSPKGLVQMIRLLRKNSNASEDDPPPTSSQAPAPTPSMDIALTLFSIINQCRYLRKITLDFGKERYRMSLNADYLFRLMLQSGTGASTIKYLTITDLPKLYLPHNPITDWISSLYKLETFEASKIPSNFFTPDFQRKMARTAPPILCMTLKDITLWDTEADLVPNLWIPPSLESLTLENCSELTTSTPILSTVSLSCYHLRELYLPVKKNKLALVSRRSSGRGGAPPHGAPRRSPLEHGICQIVQHCPSLRVLDLAGNSGISNSVLLSICTMGENLVQVRMDDFRNFTGRDLQWSNSYHVDDISTPFSSAIEPQALATVTDFRPKAEVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7ULL5</accession>
    <name>A0A8H7ULL5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7ULL5"/>
    <dbReference type="OrthoDB" id="74545at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="833" mass="95570" checksum="312565581F7714EE" modified="2022-01-19" version="1">MSSLNQILYEVTSEKILELQNQKVTLESYYRGVLKRADATDDLVQEIEILYEGIKEAPVHQKTNVNMESAGLFIEHIAKDISTSDQLRRQWIDSFRKEIQYSICKCTYSYVFGKSLRDELKDADAAPLENEFYVVSKEKKDQMNEREKTIKELEERVFESGDIQVDALTSFLEQTFDMEDVAVKDALDECRKSTKDFCENLLETDISTYQLRHCVSGLLSSDLLSGEKLTSLQQLKENEPYLQDLATLLSSRLRAIKSWSWPAHGVHVDVRRSIAGRYRAFLDEDIITALFLQYIGVSFAVHIKAKLRQMYDSRLWKRVSAKDGSIHKHRNNTHAANFLSVLPDSMDSQGSFAYEYSESGANNAVNVKNSLIHLLATDAQLHKICKPDQPFTVVRTDMEWFGPSIEHESITVVMKFLGISDIWVDFMIKFLKVPMTFQQDTEEDVKVRKRGVPISHELSTLFGECLLFMMEASVNRETGISLHRIHDDFWFWDSDQAKIVQAWEVMNKFAKLVNLKFNEEKSGSAVVSSSKTGTAIAEFGPEPLPQASVKWGSLVYREDGLFQIDQEAVSTHVEEMRSKLKNTKTVLSWVNVFNKYMAFFLRSFGSCAKVFGMQHLEQIFSNLQLIQKKVFQEQNGNALAALTAQFEILQATDMLDMWAYWPLPAGGLGMKNVLLELGALKVTLSKVEHTDFSDLPKLDKHKWEHEENEKEEKRRKQGTDGNPSFTMKSELKPQTFERYCDEREFSLAYWKNRYAELLEIAAPADQSNLDAGLTMQLHRLPLEGDNLEYAQRVIAYYDNQLGRAFGSLEFIDMSLIPKSLVESINKAKVQWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UM12</accession>
    <name>A0A8H7UM12_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Magnesium-transporting ATPase, P-type 1</fullName>
            <ecNumber evidence="4">7.2.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Mg(2+) transport ATPase, P-type 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">INT43_006755</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates magnesium influx to the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Mg(2+)(out) + ATP + H2O = Mg(2+)(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10260"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.14" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UM12"/>
    <dbReference type="OrthoDB" id="158672at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015444">
        <property type="term" value="F:P-type magnesium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006415">
        <property type="entry name" value="P-type_ATPase_IIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01524">
        <property type="entry name" value="ATPase-IIIB_Mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01836">
        <property type="entry name" value="MGATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="825"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="900"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="933"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="89"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG2183744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="965" mass="107211" checksum="06E5D1F84722876B" modified="2022-01-19" version="1">MKSEQTPKVVQIEDQNHWPQVEFEAGNDDYSFTGTVGKDEKEERKESVKEQKNWKRWLGNLQTVFFWNRSVNTDEENAKEKKTAASIQHYARCDSKELLCQLKTNILGITSDEAVHRLACNGRNDVPAIKPIPWYTMLMTAILHPFNILLMTMGIISVAVPGQGPDMMIFVSVMVVISTAIRFSQEHQSQHTFHSMRNMVATTTRVGRVIDGTSTEVEIPSNELVVGDILRLCVGSILPADVRLLISKNLSVSQSTLTGEYLPVEKSAVSSKATVPTLDTANVCFMSTSIVSGTATAVVIGTGQNTYISTVYSMLNSKAIASASSSFDIGVKKVAYLLLAFGCVMVPIIVVLNGFTTHDFEGAAFFGVSVLVGLTPEMLPMILNANLAKAAVDMAKCKVIVRKAEAIQTMGAVNILCSDKTGTLTKDEIVLVSYLDSDMKMNENVLRNGYYNSYFSKAFHNSMDSAIFCKASELQMDSHKTQYSLVEEIPFDFNNRRVSVILQVPGGKNRLICKGAVEEVVSICTKVRRFTAETDWNDADLVEDERERLIQECQKLNCEGYRVLAVASKSVATVTDQNLDEVSFAGNDDHGLTFIGFLTFLDPPKTDCAQAISDFATYNVEVKVLTGDNLEVSTKICNDVGVSTINTTTGPKLSLMSPEEFEQTVLRCSLFAKLTPLQKLEIVNCLKHNGNTVAFLGDGINDALALRSSDCGVSVEGATQMAQDAADLILLEKNLTVVTKAMIRGRITYANTIKYIKMAASSNFGNVFSMLIASAWLPFQPMQATQILTQNLLYDFSQIAIPWDNVDPEFLIEPHTWSAKGIFKFMIFFGPLSSVFDIYTFMVQFYFFKWQGNSSDPVEAALQISKFQTGWFNEGLITQTLIVHMIRTQKIPFFQRWPSWQLLLGTGIIIVIGLAIPYTPLGTNVLQMSSLPWLYYPFLILANVGYFTVTQLMKQLYMHFFGEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UN33</accession>
    <name>A0A8H7UN33_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UN33"/>
    <dbReference type="OrthoDB" id="286814at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="353" mass="40483" checksum="7BC3C54B3D4304D8" modified="2022-01-19" version="1">MKRKSGNRSAMRKEQSQRDKIKALADRSTQFSVYRQFLEHVKNTGMEGEHTKIPLDLIDLTATLIATMISGHSYLKFFIAPTIGLENGYFDIMEDLKSDINFIRKTLNMARISCTSLVVSLWYVDKFFHHKSKRHLRARKLDDSFNSSLRPNPAEGWSTRDLFMASIVTADKYLADVTWSNAEWAVNTGGYYTCDAINRLERQFLRQMDFNLFVTDEQYRHFCNYLEVSLHLRQVVQYSGSSLFSLSYQDVSVLSQSLLPVYAERLKLSLRPFEAIVLLAKMVALTFAIYLATLVTLAAAAYIIHIQAELIRQHLVSTLYSQMHTMCEYLVASYAHTFRTTGTNGVVVQSLPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCD3</accession>
    <name>A0A8H7PCD3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_002890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCD3"/>
    <dbReference type="OrthoDB" id="2404955at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF170">
        <property type="entry name" value="DYNAMIN ASSOCIATED PROTEIN 160, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="124"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="125"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2171268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="240" mass="26348" checksum="AFBBA604F53258BE" modified="2022-01-19" version="1" fragment="single">MIATHAKRIFEKSGLPADTLNKIWNLANMRRGGSINQTEFVIAMFYISRIMDHTIENVPSSIPTSIYNSAAGRPGSPTLSRQPTISSPVLRNHTGSNTGPSPAAMFGQAAFADMFDDTWAIPQDQRTKFKSFFQQLDVQHGGSISVDEAFTFFRNSGLPQMDLEQIWGLTGAQSGNRLDADEFTVAMHLIHERLNGKSIPFSLPQELVPPSHRTGRSGLSRQDTYSSAFHQASSAFPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCZ9</accession>
    <name>A0A8H7PCZ9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_009055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin interacting component (NIC) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCZ9"/>
    <dbReference type="OrthoDB" id="203824at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007231">
        <property type="entry name" value="Nucleoporin_int_Nup93/Nic96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2171394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="120" mass="13484" checksum="3A6DAE4DD32C2C87" modified="2022-01-19" version="1">MTASLSLKQIFEKSQLLTTHITNPELPPLDRGIDQIEHLSHDLVQNGDEKSAKIDIRAHYFLAKGGVNAQAMARHLDAVKLTATFDLREPVRDTDVDGYLRLEHQRVVAHTVEAGRCEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDJ5</accession>
    <name>A0A8H7PDJ5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">E2 ubiquitin-conjugating enzyme 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin-protein ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_008089</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDJ5"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23796">
        <property type="entry name" value="UBCc_UBE2G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000008">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="12">
        <location>
            <begin position="20"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2171709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="181" mass="20350" checksum="A0DEE28DDAB70ECE" modified="2022-01-19" version="1">MYDSKEVRYLKQYIEATTGHWDYLTFGVLAELTLNAPEGIMAGPVTEDNFFEWEALISGPEGTPFEGGIFPATLKFPKDYPLSPPIMKFTCDFFHPNVYADGTVCISILHAPGDDPNMYESSSERWSPVQSVEKILLSVVSMLAEPNDESGANIDACKVWRSQRERYNEIVRANTRKTLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PE50</accession>
    <name>A0A8H7PE50_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_004803</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PE50"/>
    <dbReference type="OrthoDB" id="446044at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF1">
        <property type="entry name" value="MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="8"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="113"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="207"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2172262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="34445" checksum="9AA455059810987D" modified="2022-01-19" version="1">MPIANEPLPPVGHAMAGSAGAMFALACVYPLDIIKTRIQVQAKHEGIKSTEAQYDSALDGIKQILKAEGITGLYAGLPSSLIGTASTNFAYFYAYSFLRTAYNKRYNPQAGTLSTAMELLLGAAAGALTTLVTTPVSVITTRQQTLPANERQTVVETTRTILEEEGIAGLWKGVKPSLVLCVNPAITYASFEKLKEYTLKSMQIKALTPLLAFYVGALSKTLATVVTYPYIMAKVRLQWKAPKEMEGKIQAYTGSFDVLSRVLKTEGFFGWYKGMSTQISKAVLSQALLFMMKDIFTRYTIMVFALVRSLKVKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEB7</accession>
    <name>A0A8H7PEB7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_004895</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEB7"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16630">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047544">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058758">
        <property type="entry name" value="UBA_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF42">
        <property type="entry name" value="FINGER PROTEIN (ZIN), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26191">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26112">
        <property type="entry name" value="UBA_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CUE" evidence="8">
        <location>
            <begin position="94"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="271"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2172353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="639" mass="72766" checksum="322308F81D2712BB" modified="2022-01-19" version="1">MFFSLKSGESRHVSRFVPCSAVQLTLLMLPSKLQRGRQLAQLISLFPDADPNYLLDCLAYYESDHIERISDKMLSFNGHYPRRSAHSEPGSVHMKNEYLKYLATELFPDCHVTLLRQCLLEQKHSHIEAVCESILQRKQLPVRLQSGSIERHELITSERYRAHALARLTHEYPNVWKSSIRAVMAENNYSYIKSHAQLAEMGSGGFWVSIRNLIRHWSPASSSSTLPANEDSPELAEELQILRHKTLEVQKGHDHKLAVEVNEKEYAAAGEFIPCECCFDDCTFESLYSCSTGDHLFCQECIQRFISEGIFGQGNLRGVSPIACMNSSSDCEGIFTRQTLEAALTTNVWKTYEQSLTNEEISRSSLSVVQCPFCEYCEVDDNIRPLPVIQEYIPLLVFVTACIVELPVVLIIATWLRGMAAYLTLLFVHISVQWTLHFADWRDQVRIAHKRIQERHRGRAFQCRNSSCGKLSCLLCHNAVKGLHSCKDDAQDGYRLYVEKAMADAVKRTCPVCSLSFQKSDGCNKMTCRCGYTMCYVCRKDIGKESYAHFCQHFRELPGRACGDCSKCDLYKTESEDLAVRRAARKARQEYLAAHPEVQNQMEKSDDYAIGPPTATEAIYHNVQTNFQAILERILELIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEN4</accession>
    <name>A0A8H7PEN4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_004805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEN4"/>
    <dbReference type="OrthoDB" id="48651at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF11">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="102"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="177"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="211"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2172264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="335" mass="36821" checksum="1D4EB267D338DB6F" modified="2022-01-19" version="1">MSLGDFLGDESGGASWADEMADLPTAPAASIGMQTQTCLPEKSSAPQDFPVDLHCNSDHCIILTRASDESRDDGFSRGPRRDDDRPRFASRPPADLPTEPPFTAHIANLSFDAVEDDLADFFKDMKSTDFTNQIANIRVLRDRETDRPKGYGYIEFEDQESLKSALTLSGEPLANRPIRVNIADPPKDRTDRVPDRTETSSWRRTTPIEPSSREPRRGYGFGGDRDGPRGGFRDREGGDRERGGFSDRGRDTSWSGGAFSSKRGGFGGRDGPSERPRLQLQPRSSTGGGGASQANDAPRSNKSNPFGAAKPIDSDEALKRLEDKRKPKDQEEQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEP5</accession>
    <name>A0A8H7PEP5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEP5"/>
    <dbReference type="OrthoDB" id="2425310at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="298" mass="33222" checksum="352918D9717C98B9" modified="2022-01-19" version="1">MAAAHASTAQLNNTTVRLAAMTLKERQTASATGLAEASTSNEASSSMNLPGNEESQNELKLAVYELIALATVQRPFVRITVDELFRNSISLVKKPTIQSDASSIIADNLRRLNIAVRGEAKRMASTDHGRTLDVLAAWNALLEKHFSWDEQRNQFLAPLQVMEFLKWLVTNYHQGKELTSRESKMYRVPSGGWQDAINFFVTSELQPKKATDTPTEEQLSQSATLMSPGLSRQSIEHLVTYTSQDDTLDFLWSDEEEGDAFDKEESEDEEFHHSNEIFGSATEISGAEVTDSDWSVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PES5</accession>
    <name>A0A8H7PES5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable alpha/beta-glucosidase agdC</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">INT43_004887</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PES5"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF67">
        <property type="entry name" value="ALPHA_BETA-GLUCOSIDASE AGDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034462805" description="Probable alpha/beta-glucosidase agdC" evidence="17">
        <location>
            <begin position="18"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="19">
        <location>
            <begin position="110"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="18">
        <location>
            <begin position="273"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="20">
        <location>
            <begin position="717"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="494"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG2172345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="930" mass="103424" checksum="9EB4D601507853DB" modified="2022-01-19" version="1">MKSSLVVSLFLVVAASANQLVSRANQDDPLSSCPGYKASKVKTNHNGLTADLTIAGKACNVYGSDLTDLTIEVVYETADRIHVKIQDAANQVYQVPSSVFPRPSASHSVKSNDANIKFNYVASPFSFSITRPHSGEVLFDTSAASIVFESQYLRLRTALPKNPNLYGLGEHTDPLRLNTTNYIRTLWSQDAYGVPTGANLYGNHPVYFDHRLSGTHGVFFLNSNGMDIKINNTNGEDQYLEYNTLGGVLDFYFVAGPTPIEVSQQYAQVAGLPAMMPYWGFGFHNCRYGYQDAYNVAEVIHNYSQANIPLETMWTDIDYMDARKVFSLDPQRFPLSMMQDINDYLHAHDQKQILMVDPAVAYQPYPPYKRGAADDIYLHRQNGSFWLGVVWPGVTVFPDWFNSDTQKYWNNEFSIFFDAKKGVNVDGLWIDMNEPSNFPCNFPCDNPWAAAVGYPPPPPAVRTPPRPLPGFPCAFQPPGTCKHGSRRALDARAEDGQIAPLEKRASFKPGHGKEQGLPDRNLLYPEYAIHNAAANNYSANAAAGGISNHTVNTDVVHKNGLVMYDTHNLYGTMMSSASHGAMLNRRPEERPLIITRSTFAGAGTKVGHWLGDNLSDWPHYQLSIRSMIAFASIYQVPMVGSDVCGYGDNTTEQLCARWATLGAFSPFYRDHNAYPPSISQEFYVWDSVAEAARKVIDIRYRLLDYIYTALYHQTVDGTPLINPMFYIYPNDSNTFGIESQYFFGPSILVSPVMDEDSTTVNQYLAEDVYYDFYTHETVQGKGDHVKINDVNITSIPLHYRGGVIVPQRVKSAMTTTELRKQDFELIVAVGTDGKASGELYLDDGLSVHQHGTTYVKFDFDGTTLSMKGSYNYHGARALKITSVTFLGLKSQPKSFSDEGDSSTMSTKSSNGDVVVTVSKPLSGDFTIKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFF1</accession>
    <name>A0A8H7PFF1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_000016</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>glycerol + ATP = sn-glycerol 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFF1"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000177">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000108">
        <property type="entry name" value="Glycerol kinase, glycosomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="13">
        <location>
            <begin position="4"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="14">
        <location>
            <begin position="267"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2172669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="527" mass="57231" checksum="B546958E0D0AACFF" modified="2022-01-19" version="1">MSTYIGAVDSGTTSSRFLIFDENGNLITFHQVQHTMLYPEPGWVEMEPESILAAVVECIDKAIKRFEMMGRLVSDIKAIGITNQRETALVWDRKDGKSLHSAIVWSDTRTHDIVKNINSNKDEAVLVRDLSGLPVTTYFSAVKYKWLLENSPAVQTAVESGDAMFGTIDSWLMYHLTGGASQGGVHVTDVTNASRTLLMNLKSLKWDPILLNIFNVPESVLPEIVSSAEVYGHVKSGPLVGIPVAGCLGDQQAALVGQKCFEKGDAKNTFGTGAFMLFNTGDEPLISQNGMVTTVGFQFGKNKPAYALEGSIASAGSAIKWTRDNLGLIQSSEEIGPLAASVEDSGGVYFVTAFSGLFAPYWRDDARACIVGITHFTTRNHIARATLESMCYQSRAILDCMKQDADAPLRSLKVDGGVSNSDEAMQILSDVLGIDVTRPKMRETTALGAAIAAGYAIGRWTKYSDLDNVNVEGVTSFQPKIDTTKRDDKYKDWAKAIERSYGWAQVSQVNETIAPNAPVPETTVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFG4</accession>
    <name>A0A8H7PFG4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_000052</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFG4"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098797">
        <property type="term" value="C:plasma membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903569">
        <property type="term" value="P:positive regulation of protein localization to ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2172705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="128" mass="14930" checksum="FB5C0DE6B308875E" modified="2022-01-19" version="1">MPKEPVQLLDDEENFTPRFEQVLEEIFKRFDKGNKGSWTTEEINEFATQTNGKPFDKETLEEIETFFEVTEGGNLTTNGFMQMYHLQTQNDPEETWKDLKTYGYDDSLNLVSSRTEDERPETPATESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PG06</accession>
    <name>A0A8H7PG06_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_004547</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PG06"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="FATTY ACID TRANSPORT PROTEIN 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="71"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="534"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2173173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="655" mass="73718" checksum="38353A5D64ED633C" modified="2022-01-19" version="1">MPSANLLTKAALAVASLMYLDSKLYLSKDLGEIANGIKTKNYIMERYWFVLRWAYLTKNENHFSSYSVLEEVIHANREKEAFVFCDRSSGELVLRRWTYAQMEEEIAKLADYYLSLGIQAKDVVAIYLPNTPQLFFSFWALAKLNAVGALINSNQTGLPLNHSIKISKAKLIIAHGTNYQAVSDIEGDLVNPNIVILGYGEPVPEKCQYRIDDVTTLRRTGKSDELRKTMKVDAGDSLCYIYTRLTQIPFHFTLVSGTTGLPKAVAIPHRTAMLPMYSQRKSGLIFPYDKWYCCLPLYHSSGLLIAMCGSLSVGATFVLSTKFSATNCMEEIAKSGSTGFSYIGEIARYLCLSPPSPYDQAHNIRFAFGNGLSKSIWNKFRERFNIPIIIEFYGSTEGNTFMRTINTGPDGVGYFAHRGPLLRLLAPTVKIVKQDPETLEPYRDPKTGFCVECDYDEAGEVLGEHIPLIGQSRAYVDNKSANQKVTMRDVFKKGDTWHRQGDLLKMTKDGWYEFVDRVGDTFRWRGENVSTMEVSTVMSHHPDVDDVTVYGIALPKYEGQVGMATVVSPTPNAVVKDLRKFLQTKGLPLYAHPRFVRFTDVIPTTQTHKHQKAELKKESIDVYNVEPIYVLTETGAYVKMSEKEYNAVQGGLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PG75</accession>
    <name>A0A8H7PG75_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Propionyl-CoA carboxylase beta chain, mitochondrial</fullName>
            <ecNumber evidence="2">6.4.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Propanoyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_004669</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>butanoyl-CoA + hydrogencarbonate + ATP = (2S)-ethylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:59520"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:60909"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:59521"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57327"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23721"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The holoenzyme is a dodecamer composed of 6 PCCA/alpha subunits and 6 PCCB/beta subunits.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.3" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PG75"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051047">
        <property type="entry name" value="AccD/PCCB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842:SF2">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="9">
        <location>
            <begin position="39"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="10">
        <location>
            <begin position="299"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2173295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="561" mass="61660" checksum="756C3657D563E4A7" modified="2022-01-19" version="1">MKGSDDTTPNTQRRLESIKNHLGNQSSSTSSEAYEKSEWKDILDTVKGRRKQNREPNKNHHGYVRQKTQGKLWVRERIGGLVDQQSFREIGSTAGNGKYDEKGNPIEYNPANFISGIAKVNARDVVIAADDFSIRAGHADGAVWGKSLYTEQLARKLKIPLIRLIDGSSGGGSVTLALKNGTYLPPLIGMHDSIASLSEIPIVAAALGPTVGLGAARATLSHFSVMASTVGSLFAAGPPVVANATFETVTKQELGGALLHTSNGTIDNLVETEEECFNEIKQFLAYLPSNTSQLPPRGSLDDPVERCDDRLLNIIPKRRQRSYQVREILELVLDQGSWFEIGQRWGEGAVCGLGRLNGYPIGILAFDCSKTGSVISTAGSQKFRRHIDLCEVFGIPIVNFADYAGFTIGTKAEKEATIRHGSTLIAALYQGDVPYFSVVLRKVFGVAGAAFVDNRIPNMRVAWPSGDWGSLPLEGGIYAAYKRELDAAGENRNQLYESILAQFEAVRSPVRTAENFDIPEIIDPRHTRPILCDWVRLMYENILPQRLEKVKVYGPKVQYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGU1</accession>
    <name>A0A8H7PGU1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">tRNA:m(4)X modification enzyme TRM13</fullName>
            <ecNumber evidence="3 15">2.1.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_005137</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>adenosine(4) in tRNA(His) + S-adenosyl-L-methionine = 2'-O-methyladenosine(4) in tRNA(His) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43196"/>
            <dbReference type="Rhea" id="RHEA-COMP:10401"/>
            <dbReference type="Rhea" id="RHEA-COMP:10402"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74477"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43192"/>
            <dbReference type="Rhea" id="RHEA-COMP:10399"/>
            <dbReference type="Rhea" id="RHEA-COMP:10400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15">
            <text>cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Pro) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32767"/>
            <dbReference type="Rhea" id="RHEA-COMP:10397"/>
            <dbReference type="Rhea" id="RHEA-COMP:10398"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the methyltransferase TRM13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.225" evidence="3 15"/>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGU1"/>
    <dbReference type="OrthoDB" id="258806at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106050">
        <property type="term" value="F:tRNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007871">
        <property type="entry name" value="Methyltransferase_TRM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039044">
        <property type="entry name" value="Trm13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022776">
        <property type="entry name" value="TRM13/UPF0224_CHHC_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021721">
        <property type="entry name" value="Znf_CCCH-type_TRM13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998:SF0">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05206">
        <property type="entry name" value="TRM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11722">
        <property type="entry name" value="zf-TRM13_CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05253">
        <property type="entry name" value="zf-U11-48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51800">
        <property type="entry name" value="ZF_CHHC_U11_48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="11 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHHC U11-48K-type" evidence="17">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2173717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="494" mass="56376" checksum="DFF2FA7986FDD2E4" modified="2022-01-19" version="1">MPKEQHMKPSEAAKRSKSKAKKPAEPIPPPPDRPQQCQYWVARKRRYCHLPSKKTNKYCGEHLTEQQKEDINQDTRIRIPCPFDPLHTVFQDELEQHLTQRCNARPKENDAWHSLNVNCTLPLSKEELEFQQNIHSHKHMKAQPWIAKVKLNELPKPDLRNLIMKVETLYKRLVPPIKLDIRSHASMAKRQAAVKFTKHADQQASLIGHMSHSGMLRDKNACYVEFGAGRGELSHYLKHALTAAGESTFVLIDRKTVRGKFDSALIGEENPSVVKRVTVDIKDLALGKIDVLKDNEDHLKPVIAYSKHLCGSATDLTLKCLANYADEQIANNNKHPIPGIIIALCCHQLSRYEMYPNTNYLEHNNISKTDYDRICKMSSWAICGRPKAIQVTDEGVQIDKEATAMNGIDSDDEEEEHHPVDEEDGDFDETTAHYSGLDHEKREVIGFCCKRILDAGRAEFLRQHGFNVELVYYADRKTTLENCALIATPKLDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PH27</accession>
    <name>A0A8H7PH27_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="4">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_005133</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PH27"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000013">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000132">
        <property type="entry name" value="Aspartyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="16">
        <location>
            <begin position="227"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="17">
        <location>
            <begin position="698"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="507"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2173713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1003" mass="115744" checksum="EECD796B197DB875" modified="2022-01-19" version="1">MEKDFSPQVDQLLPETESLQQQGKLQEALEKLLTLEKQARMAADQASTGRILIQVVKLCYESREWKLLNEHVILLSKKHGQLKAATTKMVQEAMSHLDDTPDMETKLELIDTLRTVTEGKIFVEVERARLTRILAKIREDEGKIEEAADILQELQVETFGSMEKREKTDFILEQMRLLLAKHDYTRTQIISKKINTRFFKDEENEDLKLRFYDLMIRHAMHEEQYLNVCKFYRAVYDTKSIKEDESKWTDVLQNIILFIVLSPYDNEQSDLLHRIYSDPNVTKISLYNELAKCFVTNELMRWPKIEEIYGSTLQQTSVFSTADEAGRKRWSELHNRVIEHNIRVIAKYYTRISTKRLTQLLDLNEQESEEFLSKLVVSKTIHAKIDRPAGVISFQVNKSANQILNDWSNDINSLLGLIEKTCHLISKENTVDYECRTTIRSSSSRDYPEDREHCLGVSTQINEVWFEQPNTWLLTFANSENGQPLSKKALKKLEKEREKAARKAETAARVAQEQAANDTPDYSTGKYGKLPMNQSQERTGRAREDITKINASRAGETVLIRARVQTSRAKSSKLCFFVFRQGVSTIQGILATDEDKISKQMSKYGASIPVESIVLVEAEIAKAEEEIKSCTISDAELKIKQLHVIAEAEQRLPFSLEDASRPESEMEKEDAQFSRVALDTRLNNRVLDLRTTTGNAIFKIQSGVCHLFRDFLYKRDFMEIHTPKIIATPSEGGANVFSIKYFNTEAYLAQSPQLYKQMAISGDFNRVFEIGPVFRAENSNTHRHMTEFVGLDMEMAFEEHYHEVLDVLDEMFVSIFTGLKEKFNTELEAVKRQMPFEDFQFLPKTLRLKFADGIAMLREAGVELGDYDDLSTEQERFLGKLVKEKYHTDFYMLDKFPLAIRPFYTMPDPENPNYSNSYDFFMRGEEILSGAQRIHDAKFLEERCKIHGVDMKHIQPYIDAFKIAAPPHAGGGIGLERVVMLYMGLGNIRRSSLFPRDPKRLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PI11</accession>
    <name>A0A8H7PI11_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PI11"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2174100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="229" mass="25869" checksum="73E96290DF9C89BE" modified="2022-01-19" version="1">MTAQESFNNPLRKFKLVFLGEQSVGKTSLITRFMYDTFDNTYQATIGIDFLSKTMYMEDRTVRLQLWDTAGQERFRSLIPSYIRDSSVAVVVYDITSNRTILVLTVMQNVSLTNVARFIDRNSFLNTAKWIDDVRVERGNDVIIVLVGNKTDLNEKREVSVDDGEKKAKEYGVMFIETSAKAGHNVKTLFRKIAQALPGMDNAVNDASKDQMQKVDLTSTSTEASNCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIE7</accession>
    <name>A0A8H7PIE7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PROP1-like PPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_004348</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIE7"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033443">
        <property type="entry name" value="PROP1-like_PPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF23">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17177">
        <property type="entry name" value="PPR_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PROP1-like PPR" evidence="7">
        <location>
            <begin position="280"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="331"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="659"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="662"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2174325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="688" mass="78909" checksum="665334001AAD9C0C" modified="2022-01-19" version="1">MKQITRKDMIALVHTFLPSQSIQGTKTAKSLTLQAIKILKDMETYQILTLNKQELELMVRLSVSVDQFGVAQNIACRLEALGPLSDVVREQLAIAMARCRRFEDCETLCSRIPNLNVCAEQVNRMLLEKDIPRAKATLEKHQLTSLDRDTLDHGLDQLIIHCIRERRDSMMGIELFKRKRELGFSGSLVARLLADRCMYTMQPKMAWQLLEIAQATNDIKSIQGIANGMTKQYLAQRNLNHAMDVYMSTRLKTKRRSPLPMGTRRDLMVALARTSRVADTLLVFKDIHHTTPYRFTNSTYHSLLRGLIDAYADDDVRFVYKRLQRRGIIPNLDTFHVLMTFCGRSGDTEFAKTVVQDMASRGLSMTHKMYTSLMACYVKAHNPRSAIAVFQTFVQQSGEKPDIYDFNILLRTTVSPGISADDTNTKIVAILEHMKRVQVMPNDVTMLTLLQIYDEVAPNQAETLWQRIVDTGMLPSVRPVRTSNVMYTRMIEKEGILTAGYHFFDKQKGAAQVPVNGITYKLFLDAATISPATMGLANKFYKDMRARGIKPPQSVYEKMISGWSRKWQISKAKRVMQDMEHDLHVKAGLIAWTRLTDGFIARKQTTDLHKLVMEEMMEQHGIVPDTFLEDRVVKALKEQNMQKELDQFVKALQLARQERQRKSLAKTKAPSRRHINEARHTRRRQGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PII4</accession>
    <name>A0A8H7PII4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_005301</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PII4"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF119">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2173881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="297" mass="32147" checksum="6572E3855F9EDD4C" modified="2022-01-19" version="1">MNTSVIATGLDSLCSQMPYMPGCTVRGICSNNSDVASQPWCNGVSLLADICVEDMPMMSGCANYNRLCSNVSVVAECKTRTMLPQLPTTKQAYQLVQDICASMSMADCDACIAPLGGGYPQCDILATYAKLCGSMPDMEQCGTYKMICVNTPSFPLCASSNGSELPPSMIMYFHQGIREYILFKNWVPQSEAQYAGAWFAIFFIAIFYQGLSVVRSNCEGYWLLKAAQESKGKFKLFGSHESTISYALMLVTMTFNVGLFFAVVTGLAIGAFFFGRHRTLGGLAEGGTKLDGCAACQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJR4</accession>
    <name>A0A8H7PJR4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitin synthase</fullName>
            <ecNumber evidence="3">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">INT43_006062</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2175000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14879">
        <property type="entry name" value="MYSc_Myo17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036037">
        <property type="entry name" value="MYSc_Myo17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004226">
        <property type="entry name" value="TBCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036126">
        <property type="entry name" value="TBCA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF13">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02970">
        <property type="entry name" value="TBCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46988">
        <property type="entry name" value="Tubulin chaperone cofactor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 17" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0143">Chaperone</keyword>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 17" id="KW-0505">Motor protein</keyword>
    <keyword evidence="11 17" id="KW-0518">Myosin</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1032"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1070"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1340"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1729"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1765"/>
            <end position="1783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1790"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="20">
        <location>
            <begin position="121"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="21">
        <location>
            <begin position="2013"/>
            <end position="2068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="17">
        <location>
            <begin position="771"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="222"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAG2175000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="2071" mass="233978" checksum="705E5621EAE7AB2B" modified="2022-01-19" version="1">MSLRDLKIKTNVVKRYIKELKSYDVEVTKQQERIDKLIERGADDADVRKQKEVLEESVQMIPEVKRRLATAHQELSTIITDPQYNGTSELEDAQKCKRPTASFFLPVAHSYRMQEDSRSDLSCLLTSGSSGPTEEAVASLLQSRFKRDLPYTRLSQSTLVTVNPYKPLDLLSDATLNAYTGAGYKDVTGQTAQLQPHVYDLATRAYFHMRRSGEDQSIVLSGITGSGKTTSHSHLLNDLLLLSTHSKKEAKLQQQILAAQTILNAFGCAFTSQNASASKFGKFQELQFNERGRIIGAKTLTFAFDKSRTTATPKDERAYHVFYSLLAGTNIDEKNVLHLNFPPEHFTYLNQSRCIKVHGINDEIEFGNLKAAMKKCGFKAKTVMQIFQILSAILHLGNLQFVDTKDASNGTQDAAAIKNADSLEIVASILGISPQKLENSLVYQLKFINKEMCTVILNAQAAAEQRDSFAQSLYSVLFLWVIEQINTKLCFADGEPANFIGILDQFGFQNFRSNGFEQLCANFTNERIHQFIINERFNSSTLNQMMAKDGIKLPQVMTMDNAECLELLCGKEKAGDREREKAANLNIGGVIGTVDRESARYQTGATDATDANLLSNLQKQYGSHPSFVKSGHAYSFGINHFSGTVHYTMDDFLEKNLDALSPDFVNVLRTSSNNNFVSALFQSAVVATESHPKDDRTIVKAQLPSKPVRAPSMKRVKRRPTLNPDFASTAIPEDQELDVEEVQRQKAIKEAEEAYQNMQVTTVLDQLYMTLRDLCLTISETRCYNIIHLRPNDLQAPDQFDTKRVKTQIRSYLIPDLIQRCCPRDYANQYTFGEFLARYENLVTGLQIDTTRTEQSQVDAICASMGWTDTQAFVGHEMIWLDFVTWKVLEDGLRAAEKEDRQKAKLMTGDNETEFAVEDRPAMASHYSTGSQDRLLPPNRGFVQGAAAAAAGGAAASYYDDHGSYMESEDDFGAGGRKHMEGSQWGEESDWGNKELADAFGPNRDMSKMIQDYRYHQEETVEEVPITNTRIWWVRFVWLMTFWIPTPFLRWFGKMKREDVQMAWREKVTICLLIFLFSAVTIFFIVGLSPVLCPGTSTLYSTSDVGNHNLQNDFYVSIAGQVWDLTSWIPGAVGHGGSAYPTAQSDMAALAGMDVSYVFPPPMTQACPGLVTTDTVKVTPNTSIITGPFVHTSGSQQLVPTLTKLTPETWYFQSFLPEFNKDYRKGDLVHKMSTLNSDFNSWSRMAGVINGKVYDITDYLSTAAIMPENNPAVPNYHYLDSTVEQIFQKYGGGDMTDAWNKYTAGLNETYRAQNLNCLNNAFYIGRLDYRDDLRCTFTNYLLLAFALMMCLTILVKFLAALQFGGKPTPEDHDKFVICQVPCYTEGEESIKKTLDSLAAMTYDDKRKLLFIIADGMIMGSGNDRPTPRIVLDVLGHDPKLDPEPLMFKSIGEGSKQLNYGKVYSGLYEFEGHVVPYIVVVKVGKASERSKPGNRGKRDSQIICMNFLNKVHFEGEMTPLELEIYHQMKNVIGVNPSFYEYVLMVDSDTEVEPDALTRLISCMLHDGRIIGLCGETKLVNEDRSWTTMIQVYEYYISHHLSKAFESLFGSVTCLPGCFCMYRIRTPTKNTPLIISPKVIKEYSDNHVDTLHKKNLLHLGEDRYLTTLMMKHFPQYKMKFTPHAQCKTVAPDAWKILLSQRRRWINSTVHNFLELVFLPELCGFCCFSMRFVVILDLIGTMTLPVSVAYLAYLIYVIASGTGPFPKIALIMLAGIYALQAIIFILKRQWQYIGWMIIYILAIPIFSFFIPIYSFWHFDDFSWGNTRVVIGDNKKKQIFVADDEKFDDKMIPLKKWSVYEQELWEMGSSRSGETGVTGQSYRTHHTLYSRGPAGTVYSSQHDSQENYDYYRDTKLNVEKPRGRSTSPIAPLHGGSRYAGSVMQEGSVYGEYMTPQMSSRAYSVNQDYEQQAAMMRAGRMTPSAMSEYEMTPSRPMSQYSMPMSTMSLSNSNTPPGFPRDEEIVAEIKNILATANLMSITKKQVREQLSAFFGFDLTVKKEFINTSIEYILQGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLG9</accession>
    <name>A0A8H7PLG9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_001286</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLG9"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="303"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2175639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="496" mass="53552" checksum="00CBD90AC59F233E" modified="2022-01-19" version="1">MPEVNKSSIFTDTTVATSSEYDTDEKLPYFVEASPMPGASYAALEMVESHRSLRSSMKAMEEGQSDSNTFGRVPTETNQQDGDLEKTKTNHTVESIQLDEGWRNRGWLVVAGTFLVNFCVFGITFSWGIFQDLYIKEVYAGQTDSFRISFVGTLGSACIISTGLLVAPIVQRFGFRITMAIGAVLCPLGLILASFANELWQIYLSQGLLYGLGGALVFAPSIALSPQWFVKNRSLATGISVCGSGIGGLALSPLTQALLSQVGYRMALRYLGILVFGLLAIATLLCKARWPPRRDAKFVFIDTSILTTDVFIFMGFGILVPFGYLTPFFLVPQYATSIGVSASQSSVIVGVMSAFNAVSRVLLGFLADRYGRINTMFGCTFLAGIFTTVVWINAKSYGSLFAFGILYGLTGGGFVSLLPTLTADLVGIKKLSTGLGMCYFSAMFGTLFGTPLAGILSDRVGYTACIEFAGGMTILSSLVIIILRQRRSKGVIFCII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PN82</accession>
    <name>A0A8H7PN82_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PN82"/>
    <dbReference type="OrthoDB" id="331341at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039905">
        <property type="entry name" value="CD2BP2/Lin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138:SF3">
        <property type="entry name" value="CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138">
        <property type="entry name" value="PROTEIN LIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="306"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2176923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="369" mass="41473" checksum="AE17995DC2D1A3EC" modified="2022-01-19" version="1">MEKRKAPKNQGSSSKRVRFNEEAKASPVENDLEFDHEAELETVKRRRGAVNLDGYGSSEDESDDAEPANTKNAEADLDDMFADATPEDTKATAGDKKKKIRYLSINEIEGQEMDSRGHDSDSEGEGEPKLMAFNMKEDLEEGSFDENGNYVRNKLDPNAFHDKWLQGLSKTDIAKAKAAQEKQERVEQMKEADVISSVPQDKNGVYRALIDLLQPSESVRDALVRLGGNTKKVPAWKLKKQQKKQSEPTPEQEAKRQTIDKITGLADQMMALGDFGIYDETFESMLRHLRRSGVVATDWMPGVKTGPQWEYRWAGSSDTDEVFGPFSSEQMQDWQTQGFFANGIEARHVDSEKPFNTIPEAFKYASGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNB3</accession>
    <name>A0A8H7PNB3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inhibitor I9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNB3"/>
    <dbReference type="OrthoDB" id="5518345at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052471">
        <property type="entry name" value="PBI_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288:SF2">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034819967" description="Inhibitor I9 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="11079" checksum="1FA8CF450783AE3F" modified="2022-01-19" version="1">MWPVLPHLLTVITISPLAGYRDYIMVFNRDISDEDFAQAQKDVVEANGVITHKYTAGLKGLGISIPDDTVTTFDSKEYVKFMEEDQTVHAYKEAVVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPQ8</accession>
    <name>A0A8H7PPQ8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rho1 guanine nucleotide exchange factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003407</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPQ8"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="404"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="634"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="795"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2178154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1138" mass="128997" checksum="8D8378FF371F95BC" modified="2022-01-19" version="1">MQEVPTRMRTSSTQLDDLYQHLDSFIDELTSESVALESKTLPLHGDKQLSAQNTPKLDTSYEFNRNISPSAHSGQHYLTPASPNHLFDHNKNNQLYGNEMPKLDITNELQNTSVPPAWANTRDCPSPASPPHLYQRVQHYQLSPPNSPLPMISSPNDNIANTFNNYIPAPTHIKNGNVLPQPQFLEKAIINEDGVHNDSVKYELPPEIQIEEPVFEDMSCLSILASAFSARVREQADMRELFCAIEYPESFTGSEAVTIIKQLIPNGYSDAACLKIARALMKTNPPLFYPIPYSEKSLKKNTVYNLSSEIYTLDESVQQRNEYPQGVFTPITNCYVSTCRTGCYAPRCPNARVAVNAQATANNLQRHMSMASSMASSMDTTISRAWSASVPRDILLVTPEPEIRRQEAIHELIYTEEDYVRDLYLLDELFAKPLATAPCIPVERREEFTRTTFFNYLEVQEANTRLYRDLNDRQNLCQARNEAGFVDQIGDIFLRHAEEMCKPYLTYGPNVVLTEYFVKREMLSNVLFANFLRDKEKKAELRKLPFRHFLILPVTRLQRYPLLIRAILKYTAADHPDFDSLTKTLDIITGAAAKVDAATVESKARQRVIEIADSVRDHTPQSVSRLKLEHPSRRLLMEGHLTRRSQTGVETIDLHVFLFDHLLLMTKKKKDPMNEKEEYWISKRYIPLRLLKIQEVNELSTIKNRTSSLNSTSYTSMLPAMQVPSAFVIAHLGRRGGIYIVTADSVTDKAMWKDKISEAKRAWAASHADKEPFDIRILSDTTFPGTMHGSISLNFGKVLCSTPFVGPNDRRMIAIGTSKGIWVGTEGNTGDFRHVLSMDNVTQLSFLRENGILIVLADKALYAYSIDSLCGTPSFKTNERTCQKLGQHVSFFSAGICNGKTLVVSMRKKGMDSQFKVLEPVCGDLRNPKNSKFKAGRTGFLGKTHEWFKTYREFYVGANSMSVQFLKARLIVVCERGFEIVDLDNLDMNKNLPDLSTGQFNFMAGKHDLQPVSMFKANAKFLLCYDEFAFYVNNRGHLAPSGENKESLQFRWEGTPETVINYHSYVIAFDPDFIEIRSSETGELVQVIQGSYNRCLHYNEWSPTPAIHGCMAHPFKPDYQTVFQLIMDPRAQNGPSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQB2</accession>
    <name>A0A8H7PQB2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_007988</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQB2"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="19"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2177331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="355" mass="38356" checksum="7368C1140A07813A" modified="2022-01-19" version="1">MSEGFVGFAALKPYVPGQGEPAIQLHEFESRPLRPSDVEIEVSACGICGTDIHHLTDGWKRATYPLIPGHEFVGRVIKVGGEVKQLKVGDRVGVSPSSSSCGECKECTSGFGQLCAKKIVTYNGVFEGYRTYGGYANKVRVQEPWAIKMPENISDEEGAPLLCAGITTFLPFKHHKIGPNDRVGILGIGGLGHLAIQWARAFSCKSVVVISTSASKEEEAKRLGATDFVVNTPENLKKLTSSLDVLLVCGSGSSTNWNALLNLLDNHGKLVMLDLPEKPMTFAPTALIYKHLSMVGSFVGSNVDLAEMLELASKADVRPMIEKVGNTCEEVNKGIDKLMSGKVRYRVVICGKGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQH4</accession>
    <name>A0A8H7PQH4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003298</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQH4"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF27">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="96"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2178045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="925" mass="103891" checksum="45AB6A466CA0416B" modified="2022-01-19" version="1">MYRLSSVSRPFRYYTYADFVCIPIAMTFVPYSLQPILNDVTVDPTSPPAEALSPSASSRNLFSRQRPTSSSTEARSPPGSPQGVASRFRGLAAAGKQGIEAVEAWDNNLYVGTSDGHILHYIIEEQQSESHADNARYTSRLDAKINLELGRKVVEKVVVLPQVSKAMVLCGTEKSLYSTLSFYTLPFFDPIPASIIPQIKGVSCFTHDTAEDGQIGEDGTIKLCVIKRRMIQLYKIGELVQLKKEVPLPNGAITVARHRHNLCLADMHQYKLVNLQLSTATALIPTPQSISGSQGSMPQSPGAFIPKPLIAVVGDGEFLVVSGNVNNQTTIGIFVNSVGDAIRGTLQWASYPRSITVQYPYVISLLRNKTIEIHNVRDQQCVQTLELQPGIEPRGLCMAYGIKVWAEGLTTRLRQHQWSPPHVAPLDNIDCDLLNQQLSRSYLIPTRLMLYNKDSIMGLLATPMIVRADALLDTNQVEAGVALANQTQLNLPQGGSGGRIRHELDYIYQKAGFLLLGETLFDDAFRLFSKGNVNPAVIIHLFGNLSIQREQNCIPDVVLYEGVKKIVDKVGRIEDIVARNIERNYSPHIQPDVETATATVELRRVLLLNAQEAVQKYLLREQIKYNKEAKGSVTSKCINTALLKIYVEKEDSNKLYELIESSSNECASKDCEYTLEKAKKYYALSLFYKYNSKVSEVLDIWTRIYTSELEDPDFTDGLNRIRDEMLELDTSQQSIDIINKYGWWLVKQNSIEGVRVFMQCKAADLLDQDDILTRLEPYGNAAAQTYLEYLVQGKGSGSPEHHTRLACSYAKDVQSAMAKTDNVEYFEKIVQDFKSQVAESEKQRISQSLTKPHTTFMAYMAKHATDSPLIQVRVRLLKLLQASRKYDPNTVMEYFISNEHLQLERVIIYGKVEVWLWGLELSQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQM7</accession>
    <name>A0A8H7PQM7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_003373</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQM7"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034416313" description="LysM domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="29"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="173"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2178120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="225" mass="24311" checksum="E53AE634005C11EE" modified="2022-01-19" version="1">MKFTAIAVALTLAATTVSAYQGPVAGCKQVVTVKKGDSCEALAASHHITVPELIKINTGLHWGPGHYCDNLDVGKKYCVKGPNSKSTSTHNKSVEHKEKCAKKKAKKAAALKKAQEDAAKKSSHKKTTKKHTTKKSTKKTTKAHHTTKKPTTSKPSGDTSGPIAHRTIASCKVYHLVTPQDGCESVMSKFHISPADFFKWNPGVHHSADHDCDNLDTGKRYCVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRE6</accession>
    <name>A0A8H7PRE6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRE6"/>
    <dbReference type="OrthoDB" id="2192830at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045030">
        <property type="entry name" value="LYSM1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932:SF8">
        <property type="entry name" value="LD22649P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932">
        <property type="entry name" value="LYSM AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="107"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="374" mass="42227" checksum="A7D9CC6F605AA4E5" modified="2022-01-19" version="1">MWPVLPKVVTPLEQFHFRFGNILTVEPLFRCEVKQTVADFKTSMNRRRLPCSEHPLSPNTNESPPSILLSTHSSPEIPTYWGQRYRQKCIHQPIRRNSEDSMYIQAILHKVQKNDTLAGIGLFYGIALQKLKKVNRLWTNDSIHSRRELYIPLKDCQAFKDYTIDKDTNTITFHKIVPQCAVPANQGTQPTSPNETAWLGINKEPRRLSFDDQLQNVSSNTYNRSRLSFGSSYPDLNHFQETASDSSYASSSDSSWYAKTNQSNDTIQSPTFPPTFIEYTAELVTVKASTLSFFAPSQHPQTSSCPPTPPLNSFLATSLPTSTYRSQTGYAKSLMDGIRSSLDSIRPSSPRPNPNEHKLTVFSSSNGSSRTTIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTA8</accession>
    <name>A0A8H7PTA8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Probable beta-glucosidase G</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Beta-D-glucoside glucohydrolase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cellobiase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Gentiobiase G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">INT43_003724</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTA8"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF12">
        <property type="entry name" value="BETA-GLUCOSIDASE G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034938172" description="Probable beta-glucosidase G" evidence="17">
        <location>
            <begin position="21"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="18">
        <location>
            <begin position="615"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG2179937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="696" mass="74032" checksum="1FE835D3ECFF8BB7" modified="2022-01-19" version="1">MRLSLSLVAIATASLITTEAAQLSWEQAYAKAKAKVANLSLEDKVSLGTGIGDGPCVGNTAAMSNASWPGLCLQDSPLAVRLAYNVTGGIAGINVAASFDRKLTLQRGHDMGQEFRGKGINIQLGPDVNMARTPEAGRNWEGFGEDPYLTGIMGALTVQGVQAEGVISTAKHFILNEQETDRTTNTSIADERTIHEIYAWPFARAVEAGLVSVMCSYNQINYTYACENDATMNKILKQQIGFQGFIQSDWGATHSGAKALMAGLDMDMPGPDDFWGANLVAAAKNGTVPMSRVDDAATRILASYYKLGQDSNFPKVQVDSDDVPSAPVDVVTSAAHKATVRSIGAASVVVLKNDDNILPLTNPKAIGVIGQDAGPTFYGIGGCTEHACYDNGTAAAGWGSGGSYFFDLVDPLQGITSRANQSKIKSSLTNDVDTATQIAKAVDIAIVFVQSNSGEGTDRSNITLWNKGDDLVKAVAAANPNTIVVVHTPSAVLMPWVNNVKAVINAGLPGEESGNSLADVLFGDVNPSGRLPYTIAVKNSDYPAHVSKPPVVYSEKLLIGYRWFDTKNIEPLFPFGHGLSYTNFTYSNLKITKSKSSNMAISASIKNSGKIAGSEVPQLYIGFPESAGEPVKILRGFDKLMLKPGQTSTVTFPLNVSKELSIYDVGSQSWQIAHGQFKVYVGASSRDIRLNGTFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTC8</accession>
    <name>A0A8H7PTC8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA excision repair protein ERCC-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_003983</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTC8"/>
    <dbReference type="OrthoDB" id="10262814at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000017">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000001">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="9">
        <location>
            <begin position="93"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2180194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="298" mass="33996" checksum="C27B361F5216B24B" modified="2022-01-19" version="1">MSERRFAIPTVEQIEERKRKSKGTNYFQTSSAKASQQEPLFVTPASNAIADSAERPPSSAVTPRSQENSPASSQQVTPPQQTGGTPRRSGPNTVLVNQSQRGNPILQHVRNVPWEYDDIKADYVVGQTTCVLYLSLRYHRLHPDYIYDRMGKLAHQFVLRLLLIYVDIDNHQDSIRELTKTSVVHDFTIMLAWSHEEVGRYLETFKAYEHKSPDIIRERSADDYMAKLTESLTQIRSVNKTDVLTLKSTFGSLEHIINAPTEALALCPGFGEQKVRRLQQAFTQPFIVNEKQKRQPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTH4</accession>
    <name>A0A8H7PTH4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DASH complex subunit DAD3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_004058</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTH4"/>
    <dbReference type="OrthoDB" id="2443965at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013965">
        <property type="entry name" value="DASH_Dad3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08656">
        <property type="entry name" value="DASH_Dad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2180269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="87" mass="10165" checksum="7B83B7123261BBE4" modified="2022-01-19" version="1">MKTLEDAVIQETQMLVENINKMNQLVAETNDAEVVALIDKLRVLEKKMSLVFTFFKASLYSLNMWQEEDHYNKNAMIEDTNRPAIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PU21</accession>
    <name>A0A8H7PU21_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_003634</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PU21"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000192">
        <property type="entry name" value="CTD small phosphatase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="10">
        <location>
            <begin position="263"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="150"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2179848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="439" mass="48795" checksum="81ABF345CAAD4E0B" modified="2022-01-19" version="1">MVKKTLFQPQPPREHPEQSTTRIKTADFAATQIENASSGCAKYGQVLKRYGKRIFLSQSNKNRGSGEKGSQNVSTDSSEKRRSNIFSRWSCCAFGVGTGIEQGSGIGEPQQTIFRNNNATSSQTETSFTDLSSKLSENEKRDIDSVSIEATLNNSQQQVSLSERKTPQTDEGTEAEEETVAPSDGSVRQTVDSSTVESELMADRDDGPENGQQTLPDPRSPASTLLPTPPVVATHTVEDTSHYQALKPPYQRHQWLLDAIADEDRGKKCLVLDLDETLVHSSFKATPQADMVVPVEIDGTVHNVYVLKRPGVDLFMKRMSSVYEIVIFTASLAKYADPVLDVLDIHRVVQHRLFRESCFNHMGTYVKDLSQLGRNIKEVIILDNSPASYLFHPKNAVPVSSWFNDLHDSELIDMIEFLEELATVNDVTTVLDNNINNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PU27</accession>
    <name>A0A8H7PU27_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PU27"/>
    <dbReference type="OrthoDB" id="10319215at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="389" mass="43470" checksum="1AB26E7DEF4C8F8B" modified="2022-01-19" version="1">MQFGEVDPAALILATVAVIIALETILRPLCKHVRKPRKAYTQFYRRAMIMADTMAAEELESDWVLSLAISKTAFMGLWSWNNTFAETLLDTPIGLGQWMLYPASLSGSGIFTAWALLLICPIWLLKAIYIKFICVSLKGIVERTQKFSIAAWLGVTVDVPVGFHIQVLENLIQTLSQYDDSLYGQRAQSVLSSLARSVSSPLGAEVSDLPGVLGCSKTDRPRNIAKMVRILLSHDVVQPIDLIISTWGLTQEQLYQIQFSCMILQQDPIERRIVECKHWAKRNVRLNRKMKQLATTSPWCDCSNFCFCSLRGIMFAPPSKSYNNMTGVIISNNVARVAKNLSLRKAGAIALAGRPIFEVLKENPLVIVGEGSVDKRRAVVLQMHDIRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PU44</accession>
    <name>A0A8H7PU44_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SRA1/Sec31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PU44"/>
    <dbReference type="OrthoDB" id="542917at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009917">
        <property type="entry name" value="SRA1/Sec31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040243">
        <property type="entry name" value="Steroid_recept_RNA_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18834">
        <property type="entry name" value="STEROID RECEPTOR RNA ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18834:SF2">
        <property type="entry name" value="STEROID RECEPTOR RNA ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07304">
        <property type="entry name" value="SRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRA1/Sec31" evidence="1">
        <location>
            <begin position="43"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="154" mass="17645" checksum="D1858DCDCF2F9A48" modified="2022-01-19" version="1">MSTIKASSPPAPEFTAYTGKDFRSATIDNHWNDPPTKIFSSAETIDVEVDSQIIHKVISETLLRCQENFKAGIQKRMVDDTTRRMNQLLKTIEDHGIEMDVLHSLCKLCQALEKREFEGALELHVKLMTKAYDNQSQWLVGIKRLIDLDQKINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PV48</accession>
    <name>A0A8H7PV48_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_008462</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PV48"/>
    <dbReference type="OrthoDB" id="4021778at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="642"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="680"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="13"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2180882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="778" mass="87600" checksum="9134077896E38DF5" modified="2022-01-19" version="1">MQQDEIAVKDLAIQVDNLTFGYGGPDILRDLTLRLPRGSRCLLVGANGAGKTTLLRILAGKRMTPGVVKILGLNAFVDAPKGVTYLGTEWAGNPTVRSDLRVDYLIKTVGGDRWPDRRDKLIEVLDVDVTWRMHQVSDGQRRRVQLVMGLLAPWDILLLDEVTVDLDVLVRSDFLNYLQEETAARNSTILYATHIFDGLGEWPTHIAHMADGTVMSLNNTDNYPEFDAFKTRHKQENRVDSPLMALCLSLLRQDKQRQLAGNPSGDKRQIDSWTGQPHTKWDDLSEDMKSYGDKYSNGKRPATHHKTNAAFQTLLNHIKYNTDKLSPETRRTLLILLRAFALGWSVSGLPALLGVIIKALVVSVKMKAFPNIQKLLANILRKLYHSIARNGLPWLFCGALGGHRLVEPLLKKLMKDGQKENAAATAKDQKRLVISSMIASALTLFSVHRLFPRTGTLDITLFAAVRAGDVFAHRFGESDYAKKKIPTWMLYNGDVIVFVLACTEIMFSWFFASARLPRSYNNWISRMAAMDHRLLEALRMIRTGDFVYGNYTEKSSILIKYCEDIGLPISYGDPRTGRIHCDIVHDGFPGGCEGNALRRFARGFSQAFMIYLPVHLLPPLLFRRQKTLENPIDSGIHILKAAMRSSTFLATFIALTWYGVCLTRTRVGHQLFNINQAKLDNTLAPLVGCMMCGFSLLIENKHRRGEMALYVAPRAIYSLMERVLGSHRRGRPWEKKVAEASEIVIFAGAVSTVLEAMYRRDDMVRSSVKGLMKWVQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PV70</accession>
    <name>A0A8H7PV70_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Early meiotic induction protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_008492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PV70"/>
    <dbReference type="OrthoDB" id="2017405at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2180912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="17375" checksum="D23D3642A62482AC" modified="2022-01-19" version="1">MSEQKEEIFDFPDIELEEKDLKPEEYTCNATQAFDAVFECYTLGAQAMNYYRYGEKKDCSVKWDDFKLCLSTKTKSPLAAKKLLDDRKKEKESLKQIQRSSEDVWTLREYVKDITASYIYSIFNQFNIHSHLGYHRQIPPLLCEMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PW26</accession>
    <name>A0A8H7PW26_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tag1-like fifth Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_008389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PW26"/>
    <dbReference type="OrthoDB" id="10039566at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022185">
        <property type="entry name" value="DUF3712"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059066">
        <property type="entry name" value="Ig_Tag1-like_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF3">
        <property type="entry name" value="PRE-RRNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12505">
        <property type="entry name" value="DUF3712"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26153">
        <property type="entry name" value="LEA-2L_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1-like fifth Ig-like" evidence="3">
        <location>
            <begin position="702"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2180810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="834" mass="91103" checksum="CA32A837449867AB" modified="2022-01-19" version="1">MSSNEPYASSSSVDRQDQSLHERVPLLSEAQGSGSRKNKGKAAIPTQHYAATSQIESDTPEIHSSRRSRRSNICFWLSIVSTIIAVTVIMLLLFAPNMAQRYFRDGVEVSFDEASILNISDADSLDIHVTGKLTLNDKLYGVARKAAALFGDISTEPSNLDVFNAADMKSQSALGTIELPELMVNRTNSTTSFSFVTPFHIGDTEQLAAFCREAVQQKEVVWKVKGPVGASVGWLPKSVSIDIEKDVTLEGMDGLKQAELKSMIFFGEHPKGGINIAGQVSIYNPSSTLSFKLGDVDFGIHAPIANSSKDALIAVVRAKDAELLGKKDNIFNVTGRSIAIDQNDTERQQAVEQFLSDYLQGKTTTVNVRGSDRGPDNDENPNLPIWMKNALGSVTLSIPFPGSKQTDFIESLALQNISIDFAAETGTVVSGSAIALMKPPPEMQFDIDVREIQPLVYLYLTKEHEKPFAKLAPTEASPATTILPKDDPSLPDNLFKVESKLDRAPLTVLPGGEEDFEKFLNKTFYGSEHKVYIGGTVKAAVVCAFGKLTIKDISFNGEISTKGMSGLLDPPPRLDSIDINHGFADGLFVLTNISLFNPSDVTVSLGEVSTYILYEDIPIGNSTLANHVILPGWNKILAEAYFAPSQSGSHEKAMEFLSRYASGDNDTQLQISGNHPNASKSPELQSMLRNFRFNSSAPLMNQTLLIATQMNIFSSTAELWLMNPFNGTTIEVLAVNATAYYEGHKIGSVHADFEDLSQGWTRRLILPSNGSVVHTEKLPVMFEVGAGFEAIRKAVGKSIAVDVDSVIRARIDDLHIDDLQYHKQNVSARVRLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWF7</accession>
    <name>A0A8H7PWF7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_008557</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWF7"/>
    <dbReference type="OrthoDB" id="1703270at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.168.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.20">
        <property type="entry name" value="Ribosomal protein S8e, subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042563">
        <property type="entry name" value="Ribosomal_protein_eS8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2180975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="190" mass="21403" checksum="2CCADDE77F62BCE1" modified="2022-01-19" version="1" fragment="single">ATGAKRAQYRKKRKFELGRQAANTKLGPKRVHEVRVRGGNKKYRALRLDAGNFSWGSENCTRKTRVLTVVYNASNNELVRTNTLVKGAVIQVDATPFRQWYEAHYAQTLGKKKGGKDADASAEKKSNHVQRKLASRKADAKVDSLLDDQFTAGRLYAKIASRPGQSGRCDGYILEGKELEFYVRKIKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWT7</accession>
    <name>A0A8H7PWT7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_008499</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWT7"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF50">
        <property type="entry name" value="BIFUNCTIONAL ALBAFLAVENONE MONOOXYGENASE_TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2180919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="631" mass="71777" checksum="71142DB901CEC0CB" modified="2022-01-19" version="1">MSTITASTIQYVDSLIKQVPGHATVEDLVAKLTAKLTAKSNRNTVLGSAALLLTAYYILIRRLELNKPKAYRAIPKIDGIKNMRLLIQNVPFVDRYNQSMKAILDDKGIGRASIGPADIIFLATPELSRQLLNNNEVFTKETVETAPAYTLVRKFFGGVNLVFSNGDVWKRHRAIANPAFHRSWDTKVFGHCADEMSEQMIKDMADHGDVELHSMFQRLTLDALGLAGFGFDFQSLRNPNGRYVTVYNDLMGGALNGMYFLFPWLDKFPMGRRYQLHKKLEEFDELLYDIIRQKKADLESGKLSPDSDLLSMMIQATNDSSGESKMSDVELRDNVSIFFLAGHDTTANALACIIYFLARHPEYQDKARKEALEAIGDDGSIPTLDQLKNLPFIDACIKEALRLCPSVAQLPARYIAKDYYTTEGYLIPKGTRATLSIYTLHHNKKYWGEDVEEFKPERFEEGKKIDPYLWLPFSFGSRSCIGQQFSMIEQRVVLTMLLQRHIFTLPANSPHKDGLIFGRGGLLHPHNLRIEVTNRVIDFPLPLYNLQMTDKQPQLINSSNAGEEEDPYDTRLQKTGCKEENDDLLVCYADKHDWRLCHAEMQAFRNCYQKNKQNAGSKELEDLERSSNNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWW1</accession>
    <name>A0A8H7PWW1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear cap-binding protein subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWW1"/>
    <dbReference type="OrthoDB" id="422106at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019416">
        <property type="entry name" value="NCBP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10309">
        <property type="entry name" value="NCBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2181303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24149" checksum="0BEF81D7DD7AD744" modified="2022-01-19" version="1">MSEEVITMDIDIDAEAEALNTISETVPETNITTDQPTQSESLPADGDEDQDKKPSGPQLRPEAVHVHGVDDMSTKDIETYFSEYNPIKIEWVNDTSCNAVFETGEQAKKAIESLVLEPAEVNHTLLRKSQPYTLESGRSINNLHLRLASDWDVKERGARERSRYYLLHGPPAKDINSRLGKRRADQPKRLGGKQDVLSRLGGYREPGEKRKHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PX88</accession>
    <name>A0A8H7PX88_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AIG1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_009008</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PX88"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF184">
        <property type="entry name" value="GTP-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIG1-type G" evidence="4">
        <location>
            <begin position="31"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="286"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2181425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="353" mass="39558" checksum="64255AE0A02770BB" modified="2022-01-19" version="1">MSVVTDNDDNMLLPPGKIISSTHLHLPTNQARPLSVMVLGKPGEGKSSLLNGILGQQAFVAKLSVSVSIITKSINLYPNGSWLGGETDIPIRCIDTPPISGRLDDAVRISNECQHMLDLAMPGIDAFLVVIKLSRYRFDAGLESTLRVYESIFGRCFWDNVIIIFSHADLESAFDDEEPSQGPEYAKSIAAAFNLTRPLPYCYTSIGRNRGRRKTADTRTMDDMKEAQVDYMDTLLMFIQSYQNTPYSPEQYRQFVSIHGKNRRSDYASDVLLPRARQVESLIMGRKEAPRSPRALHGYANPERSASLSNLPDYTRSNREPPLMRRDVAKRSPSIYTLAPNKVQPEQNKCLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXK4</accession>
    <name>A0A8H7PXK4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007404</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXK4"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710:SF217">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RDUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2182474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="17093" checksum="168045BEAEF8F1F5" modified="2022-01-19" version="1">MNRSSTCSRRVNHLIPYIDFRSMFTGIRQHVEQDDPDQQRFLDDLISQLLDEAQSNAKGPPPASERFIKTLPNIATSSLDRQEIRALKCVKRDLISYLSRHYFDRECLLPWLQLHNTCPMCRHAVETEEQVKQEEQDLARDWMYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXL6</accession>
    <name>A0A8H7PXL6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_007435</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXL6"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17996">
        <property type="entry name" value="DEXHc_SMARCA2_SMARCA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000008">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000843">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014978">
        <property type="entry name" value="Gln-Leu-Gln_QLQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029295">
        <property type="entry name" value="SnAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14619">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00951">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01314">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51666">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="QLQ" evidence="15">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="HSA" evidence="14">
        <location>
            <begin position="358"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="543"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="854"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1135"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="337"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1149"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1204"/>
            <end position="1215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2182504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1231" mass="141576" checksum="5B5B9F590C2A18CA" modified="2022-01-19" version="1">MSTTPNASTADALAALTAGLTEEKINAMLQRASFLQKQGAKEDGNNEFSQLMLILRNLQQRQLMHQQQLQQQQQQQQQQQQQQQQQQNVPRPPNQTTVTGKVAANFTPMQLSALKLQILTFKLMAQNGTIPTRIKEIALSPSNIEKLLEPRETLNLDAKVIEATLLQKDAAEQNMSKEGQSRMAPFYNQPSIEASEKAQRLFEYSTNPYNIIKKPYASHAHSSLQQRLLLPGIAPSGLDPSSVLSERELRLQAQIEAKIAELEALPFTGPNGEVTTLGQRIKDNYKQTVDNASEDELQAILELRSLKMLDHQRKLREEIVKDMGRANRLSDIDRAAYRRLKKQSMKQARMAEKLERQQRLHREKKEKQKQLDYLQSICNHGRDLVAWHKAHAAKQSKLGRAVIQYHNHVDREEQRRTDRLSKERIKALREGNEEAYLKMIDEAKDTRLTHLLRQTGTYLESLTRAVVDQQKDHVEDEDADADADADLMGDQPADEEMQYIDSHGQKVDYFQMAHRVKEKVSQPNMLIGGSLKEYQVKGLQWMVSLYNNRLNGILADEMGLGKTIQTISLITYLIEKKQQNGPFFIIVPLSTLTNWTLEFEKWAPSVSKIVYKGPPGVRKAIQQQEIKHGNFQVLLTTFEYVIKDRPALSKVRWKYMIVDEGHRLKNTNSKLTSVLQQYYRSRYRLILTGTPLQNNLPELWALLNFILPKIFNSVKSFEEWFNTPFSTQGVQDKVELNEEEQLLIIKRLHKVLRPFLLRRLKKDVESELPDKIERVIKCKFSALQAKLYDQMRKDGMLYSVGEKGRTGIKGLNNTIMQLRKICNHPFVFEDVENVINPSRLSNELLYRTSGKFELLDRMLPKLQVTGHRILIFFQMTQIMNIMEDLLHYRGFRYLRLDGSTKADDRSELLHQFNAPNSPYFVFLLSTRAGGLGLNLQSADTVVIFDSDWNPHQDLQAQDRAHRIGQTKEVRIFRLITENSVEESILARAQYKLDIDGKVIQAGKFDNRSTEEDREAFLRSLLENKNDEQDDIVPEDDGVDDEELNLILKRSDDEYTKFVEIDKEREQQEQEWWQAMGGTGKKPERLLQEHELPDVYRIEETADTLMEELEFGRGQRSKEQVRYDDGLTERQWVKALEREQDAAQQIPAKVPIPKPEPAPVPKPVPATVPKQPSASAPAKEPTPAREADAEPLDGNTPKRRKIEKGSSSQMLDNLKSQLDKISRDIAGISKDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXM0</accession>
    <name>A0A8H7PXM0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCD97-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXM0"/>
    <dbReference type="OrthoDB" id="333176at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040233">
        <property type="entry name" value="CCD97-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018613">
        <property type="entry name" value="Ccdc97-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09747">
        <property type="entry name" value="CCD97-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCD97-like C-terminal" evidence="2">
        <location>
            <begin position="109"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2181006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="344" mass="40298" checksum="57A34CBA18AC15A7" modified="2022-01-19" version="1">MDPDNQKTVMLYVTNNISSIAFKTLQRDEQERPDSEKIAYMEELLVTNPSLFLTKWGRYLPAEQLEHFQSLRGNNYEIDVQMHGLLKELPSGVQTIERENALKKKMVQNRRFQYLKDVLKDSEYFTENAMRLREPGLYDYYIGQHIPPHMRDRPYDNDVNLVQRIMTNIDRSIIDNKLRIQQQIEAEQEEEEEEEEEEEEMEHEDEDERNGDDGIADGDRDTKMLRTHSAGPVIAPLTHSLLNKSTDAQRKLKLASESENLATEASASSDSWQAFQDGQRDEFVRVMEELFLEGRDPTFDYSQVDDNEAFDDLDQADMDMQDKYFDEEENDEQIDVSGTGEYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXY2</accession>
    <name>A0A8H7PXY2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_007257</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255632at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
        <property type="term" value="P:meiotic chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="6">
        <location>
            <begin position="1898"/>
            <end position="1993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1117"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1127"/>
            <end position="1136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2182327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="2083" mass="236129" checksum="319DE6C0432A1088" modified="2022-01-19" version="1">MQQGMSSSALLKALSNSDTCNNELTQLVRKTLLDPIESSKKLTKKDIETYQRSLVPLAMNIVNQNLGSFGKLYERASNTAITNEDSDMISCLVDTSFYALKTLQVLNDTKAVKQLDVEKARSNLITKVINIKQYERALQELLLFRAHLANIIGVNLDAYSSDHGEKTVLTEALNTPSTPASPRPSKTIARQLAAELYSATNSSKHSRSPYLCLLNLPMQQNMNNISMVRLILASQLNAIRCFVEMDNGANISELPDLMESKGSFFEWCRHLASLDEEKAQEQFEYLYRLLSKQAKNNHSTNISPIIVLKLRVQSLLAAYFSKRAKFGYICDQLVRIGVTFEKTSNQVKFQNLQKHCEYILKYLEPAVDDLTGMENYFVLCEYYAYASRKCGSYQGSFFAFKHMMRPLRIVLQNTQHCQSYHYMYAASSKMSLASLQLDKMISSNAYTDINTTLMEVSSCIKFSIASLEKDAKLTKYSELAMRNLSKSVDNFRNSCNSMHTFLSKKMEDSIHRREVAHDPYQTPPQRKHMHADDFGDWKNNSANIQECLLRCTDLVPVFLRLLTEKNDPSGQGEPVNTNSLCLTYIDIIILLSRMAFRTTDPETHERAFQYLQDGAAFCEKNDFTEGKRWLSSAYYSFGANLATEGDYGKAIIPLEKSCIILEQDQLRAKTQSEQWSMQLCKRYELLGASQLKLFNQKKAILALQRALIHIPKSSIKEFVRHCDTVSLAIFIDKFPLLPKLMERYMKAAIIDRPHDEIALASEIMDIGHLNPSQRAIIKECELQILNVMSLRTNVSTLQMRLIDELLLAYEATQYPIRRARILVEKCRLLRSHKSSHPESNDKSQVVIDEALALLKGDVFAADTDLLDYRKYYLAMCYSWNGLCKQHDIQASTNSFEMALRCWGTILKPIPLLGEDAGVDDDARAYIYRQIDGVDRLYGHLRMLSDLFAVNQRRIQRIAVLRLLLQLNNGLRDKDSDNISDAVMLYTDIGSTYLELGYTGKAAAEIARAERTMKISKCNTEAKLHHLLMYAQYLTITGDVDQSAEVYQRAKELADQANPKLHFNKYKSAQNRVTRSILLAGASFTRSYLSVELGSVDNAVNDATTALKVLSRLSTSMLQKSKSRQEQPESIDNPFQSDTKRYGDTVPEEQQSHGIVQTVAEIALQDANWSMAQKMSKCFARLGSLHSARGSWREAEYFYKQGLQLSEHLGSKMATAAFLISLADLYWKTGKHQESQHKLEKASDLQSMDCPFPKDQAELKVVVGDVDGSQGYNDAAMESYQDADSILSHLMEHTYITELEQSIARTEQGTPRTQKLLQELTGSRTVFSDGDSEFDCVLLYSDHVNVVIREALITANTGELSLAVTELEQLEGSLPLLSNEASKLHAAISKLKLLQTLQGIEKLKIGQHLKKNGITLPLLKPTTSTMPMRRTTALQTLKRPRDDIRQAIERLMDALSTGVDKLEIQLVNDVCLNLTSSLFIKSLLSTAGVFLMNETATLSAYYLGTLHLNPHELSKGISFRREMQTCLYHKLKKSTSHEDEDNWPSVVPEDQTETQDDEEMIDHWYHAHLEQLRDLYKEEHELDENGFQEKFVNILPPNWTVCSLTMDPTQSNMYVTRMVANATPIVLKLPLQRFAQRSDGSDDMSYDKVVQEFNEIISASDATMHLKKKFEDKADIEAWWSERRALDSRLKLLMEKIEERWFGGFKGMLGKECTIVNSKLKVFQSYLSELVCKAAHGRSVKPTISISNKPKLLEIGLEICKVTLQLESKASSECIEDLAYYLLSLYEINDIDVNYAEVDLGQFKDDILTGIRQYHASVQKVTQEEANNGQQNHTILILDKHTQFLPFESLSVLKNRSVSRLPCLSFLRDRILYARSYTRAKSSSDSEEQTDWNDIKLNGKSAFYVLNPSGDLKKTQAEFQSALEQRTEWQGSIGQPPMEKQVQNALRQKDIYIYFGHSGGEAFMRGHTVRQVKHCAVSLLMGCSSGLMKPVGQYDPYGYVINYMLAGCPAVVANLWDVTDKSIDRFTKSMMIRWGLLPIPGKQETSYFRGLSLTEAVMQARDDCSMPYLIGAAPVVYGIPVYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYB1</accession>
    <name>A0A8H7PYB1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYB1"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031793">
        <property type="entry name" value="KICSTOR_ITFG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16317">
        <property type="entry name" value="INTEGRIN ALPHA REPEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16317:SF1">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN ITFG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15907">
        <property type="entry name" value="Itfg2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2181965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1031" mass="113069" checksum="DAC1C10CDF4FFF1C" modified="2022-01-19" version="1">MRTLSLVNRLRWSFGGNMNPHALVVGDVDNDGDNEFVIGNLNGDLAIFKGDCSYGLPAYFCRGLGTNSVVCINAEGHAHIFDFPNSNLQDVNKKSTSMQTNNVLAVEEYLQHSRRGSDTATLHNFRNAMASAQNGPKASRGKSQLGKGSEDEQLNMQYISPDHTVKVPVNVNKIIIADIDGDGLNEVVLARTDRILHSFEFKRPPSEDPSKAATAPGTPSTSTSTSSASATLNTYTRQNPLAGKNIRSSFSNITQNTLKMAKERPLPPSRGATKEDLKEPSAISKISSGWAKRDKSKATDSVHPNDVLDDDKSTKPSQGATVIEKDMWIFDGQITSLSTTMHPNYPNEPLLLVAQPGNTFTIIDQKGDRYNPDFTRQYITNSHYRRSNDQVGELATYQFDSPEISQRPPNASSVERGPVDIDNAVMAKVIDGEEYNEEMYGLSVTPKARQFMTEDTPMAKNRRSTSGTIRPMLRRASSTHAIGPEIADKSKASQVQTPPVEIKSSSYVVQSWPLVDGDDVVGDEIKGLVATEIVMGKRRHRRRSLDDSEYQAIDSVQADVVGMLSMDGKFTIHNLLTKERSEYDLFVTHKLFSLATLNTSSKPLTLPNGGHARRPSGNRSGMSTPGFSSHASSPQLKFPSPYMKPTRYNSSTTTSVADLSSAPSPAPTPSRSVSENGDSDLEDNRSLRQIPSHDEPGTTMGTTISRIFGIVSGGQGDGEASEADGDDELDFSDSEQNGSRRGSEYNGLEDSWISEAKVEIDNDLFVACAWNGVTYMIDWSQTNSNDQKYTSGTKFQLVKFAFEGRVCAFTAGSYAVLPGQNVPCLFYVDFDDQIYVYYDVHITPGPVTGFLDEPDDDIDEALDRIAACENSIKELQQRVKDPDDNEGIYQENLFGNAILATNDYRNEKADIIHRSLYGLPQLRAALSFELEQLVLAQTPFQAAHPKRGRRLSDIEIFLDPSLERDGAALSDGVVHTPSSITSPVPTTTPPDLVDRDHELMTDSDLADTEPDDDSVRDIQPISTVTTTDTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYS0</accession>
    <name>A0A8H7PYS0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYS0"/>
    <dbReference type="OrthoDB" id="64477at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:protein-N-terminal-alanine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051908">
        <property type="entry name" value="Ribosomal_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441:SF2">
        <property type="entry name" value="FAMILY ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441">
        <property type="entry name" value="RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2182591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="200" mass="23230" checksum="E59747572E1245B6" modified="2022-01-19" version="1">MSYSFPKEVSWEGLSATYRTPQLSDAPEIRAILSDLDNMKYLKFMTKPGGWTEEQVRERLSSQLKRQEENQALVVHIIRDGKVVGMSGFTVVNPEHGHAEVGIILDKSCWGKNIATEAFYFSLKWAFEEVGLHRVQWVTTGPNQGMRGWIEKVCGLKCEAINKEIWRFDGEFVDQYFYALFEDDWRNRVKNALHSKIYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZB4</accession>
    <name>A0A8H7PZB4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_007464</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZB4"/>
    <dbReference type="OrthoDB" id="10006572at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041086">
        <property type="entry name" value="YBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF0">
        <property type="entry name" value="PROTEIN SCALLOPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17725">
        <property type="entry name" value="YBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00065">
        <property type="entry name" value="TEADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="9">
        <location>
            <begin position="55"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="7">
        <location>
            <begin position="55"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2182533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="595" mass="67450" checksum="62C963B3BE3D8233" modified="2022-01-19" version="1">MLACSQEFFFQDETTDTLQQQQLAFGQSDAALKEKRIKNRRESAPNSGTIMTNGSREKEEVWPQDVEAAFVEALEAIPKLGRRKILVNGKPCGAYLCWRNELISDYIFRKTNKVRTRKQVSSHIQVLKNTRKGDSNFMRLLTDSVEIEDEFTPTAEHPTGYLSSESFTSDDSSIDSSPSPNDYVFEFMYGDPNNSQTSVPMFDLKNPMFDGLNNPMAGLKQETMLVDHNAKQQYKMPYNGFLGNMNSNMNSFGLANDLMSNLVMPNGLPTSISPSAILPSNSCSITDFMNLSFQHNARKIKKCPSIGIPRKSSITIAKKKTYKKKIDEDNTNDMTTDMESAANFPLWPNYFCLYLEYSLPYDPSITVSHTLAQLPHCYPNCLPSIDIRSIPTEKCPQVEKLSKQQPNIMLLAKMKLDLNLNIADFVFSNTSVLESKERRTVECTTTIYSFGNVVLEAKETQHALWVNEGKYMYSFEYVNQFFDAFMKGIRTLHSWDEVDIAISNLCIVQSDNELLQTFDDLDAVADEKDTPTLTKQENAFDVCHNKQPSLLAMIYEFERGHGAIDMFSIGDSYKAETVNIGKELDFLGDLQDIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZN3</accession>
    <name>A0A8H7PZN3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZN3"/>
    <dbReference type="OrthoDB" id="5551751at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034964530" description="FAS1 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="67"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2183227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="210" mass="23671" checksum="DCEEFFE224C807D2" modified="2022-01-19" version="1">MQFKIVLLAIIGLLLTNVAVAQLVPLELKDTLFASDMDSESKKDSKNLLYQEDAPDYRLSEGQGGSPQSLFDHLPKDPTLSTFMDILMQVDDVLQLVNDPYTEPKFTLFAPTNSAFQRYMSDRVKRARFDEEDGFKNFLLCHIVPEGKYSVKDLEKAKSLNTAKEGRKISVESHWIFGITLDNTAKVDKDAIEAVNGIAYKIDHVLEPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZT0</accession>
    <name>A0A8H7PZT0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein uL30-like ferredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZT0"/>
    <dbReference type="OrthoDB" id="509901at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="2">
        <location>
            <begin position="7"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2183462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="93" mass="10158" checksum="BD0300F43FEE436F" modified="2022-01-19" version="1">MSATQFFKISLKRSTIGLAPDYRAAARTLGLHRSHQTVYRPADSTTAGLILKLKELVKVENVASIPTSVEINAARKAARGYQVVEKQGAFTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q013</accession>
    <name>A0A8H7Q013_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_006301</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q013"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23022">
        <property type="entry name" value="zf-HIT_DDX59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="9">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="244"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="455"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2183296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="624" mass="69430" checksum="69B0D1633ADDD929" modified="2022-01-19" version="1">MFIPRGVKRKHTNAVYSPDIAKRAKAISLEISSQSSQIQLQGEVNVADIAATQTQQAQGPQLEQFEYENGISSEEYQHSKAAPSYKEDVVGDVDDEEPIKETSFEQRFPLDGDPICIICGRYGEYINDATDNDVCSLECKAKDIQNVARNAHHSDICPGIAIPQYTVATNVHAKLTAYHDAPELSSLYPNQVEAIRSAHDISVQGQHVPKPVLKFENCLLDDKLLSNLLEFGFSRPTPIQMQALPAALAGRDIFALAPTSSGKTISFLVPMITHCLSLAKMYGDIYRSGPLGLILAPTRELATQIEEVAKKLAKGLPHMRSALLIGGMPIPNQLYRLKRGVQILIGTPGRVIELLNHHKDALKLDTIKMVVLDEVDMMFKLGFNEQVARILNSLVDPGIRQTCFYSATSESEKSMQKACNKHMRDSIKIRIGKSPSFEPKKYVKQTFMWVETQSKAKQLMSILRDPKYFEPPILIFVDSKLATELLAQSIRKKTGSMAVAMHGDLTQPEREVVLQQVRQSECDIVVATGILARGIDLPNVRMVINYDMANTVDEYIHQIGRALVSDSSNNKGKKSHTRRNGWAITFINNVGLRRPNLIGGYATANVLVLANRNIDIYFVDWFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q017</accession>
    <name>A0A8H7Q017_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Mitochondrial import inner membrane translocase subunit TIM44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_006414</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the Tim44 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q017"/>
    <dbReference type="OrthoDB" id="10265990at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.240:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017303">
        <property type="entry name" value="Tim44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039544">
        <property type="entry name" value="Tim44-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037871">
        <property type="entry name" value="TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 13" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim44-like" evidence="15">
        <location>
            <begin position="279"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2183408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="439" mass="49571" checksum="8C6DD41FAFCA94E0" modified="2022-01-19" version="1">MSMYRALATSTVKVSKQSLVSARPAALLLKHTPNTTSVRHSSVFKAFVDTIKDQVRKNQDLQQGVKSLQDESGKVYDSEALKKARELYEKAKASQGAGSETFKKASEKFGEHAEKVGSTVNKAWKEAADAEFVKEAAEKYKKASEEFNKAADPLKKNPVVGKVSESFQTILKDESGRYGGFVDKETRRKLREESMKAEGHHKAKPVSENPEAGASMVIHKDSAWKESWNKFKEDSSFMQGIFSARKKYEDSDNVFISYTRAFTDRLQDTFGSIFDESDQAQAIKAFQQIDHTFNMEKFMKEAREYIVPELMDAYLKGDTETLKMWCSEATYNVLTAIAQAQTQQGLVSDCKIQDLRDVDLVTAKILDNDVPVLVLSFRTQEVILFRNAISKEIVFGQEDQIEQVTYACVLTKQPEELQNPVTGGWRVIDMAKHDSRPTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0Y7</accession>
    <name>A0A8H7Q0Y7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_006802</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0Y7"/>
    <dbReference type="OrthoDB" id="2282627at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05462">
        <property type="entry name" value="Dicty_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="96"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="534"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="543"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2183791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="559" mass="63023" checksum="2F5885952E52F01E" modified="2022-01-19" version="1">MAGFDNYKPAHQSEALVKPKTHQASSHSDIIKLAWVLWTCLLLVFSSPLPPFFFPSHFFFHSTSPFYSKLVMSGTSANSTYVPNLQFEFDWQNDILNEINVIGNSLSVASGMIVLIIIFALRLYDKQLVDRVSLRLSAAISVTDIISSAALLIYTYVTVEGGACVLSPFLIIFLTNLFLFLTVAIAFNLQHLFLHQRYYNPSFEKWYYILSIGAAAVTAIIPLAAGRLGLDPAQGFCWFNPSWTVTSNIYEYATYIGPQLLCGTYCLVVVFAVAFKLKLDSQRLDRRIANRGNGEHTDVDIRRRKTQKAINRVVRRILLYPLVPIITQSGFIVSEIYLYVNMRPSYPLNVWGVTLKSLPGFCNLCAFLIDPAIYNALTTIKKNLIIKYCGDAVPEPHAVSGVVSRSTYVNSSSSRIPDKQLPMPLPTNANKPQRGFMPWFVRRFLLTSTQRQNGTSSTFFMMKEPLSSTSSMPNTPKMYNSPTFGDADEESAHPTLSTNAMMKFPPKAHTHDPYTTFHDIEEDDDTVMKDGNWVEMQPTSGTQERRRQRKEERKIIGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0Z3</accession>
    <name>A0A8H7Q0Z3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Transmembrane protein 230</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">INT43_006541</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Involved in trafficking and recycling of synaptic vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Secretory vesicle</location>
            <location evidence="3">Synaptic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">trans-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Late endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TMEM134/TMEM230 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0Z3"/>
    <dbReference type="OrthoDB" id="5597044at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044234">
        <property type="entry name" value="TMEM230"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008590">
        <property type="entry name" value="TMEM_230/134"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15664">
        <property type="entry name" value="C20ORF30 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15664:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05915">
        <property type="entry name" value="TMEM_230_134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="9 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00007743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG2183535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="114" mass="12914" checksum="4472C1BB9263170D" modified="2022-01-19" version="1">MPRLTNPLRKKRQVIQLDDDPGFTDDQFEAPESPIPWKSIYLAAGLLLVGSVFVILGALIKVGIITSEIWLDRGIPFLVLGSIMFIPGAYHCYVAYYAYHRYPGYDFSMIPDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1K7</accession>
    <name>A0A8H7Q1K7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exosome complex component RRP45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Ribosomal RNA-processing protein 45</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_006638</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1K7"/>
    <dbReference type="OrthoDB" id="10264038at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11368">
        <property type="entry name" value="RNase_PH_RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000005">
        <property type="entry name" value="Exosome complex component RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033100">
        <property type="entry name" value="Rrp45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="33"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="12">
        <location>
            <begin position="193"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2183630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="283" mass="31659" checksum="F7095D3B503B87D7" modified="2022-01-19" version="1">MVREAEPSLNEKQFVLRALKDGLRTDGRRPYDFRSIQISFLSEYGHVQIQLGRTRVTRVSAKVTAEVVRPRPDKPTEGLLLFNTEISPMASPAFEIGRPSEEEVLISRTIEKALRRSRAVDTEGLCIVAGEKVWSIRVDLHFFDHEGNLVDCASIAAITALLHFRRPDVTVIGEEVTIHPMDQRNPVPLSVHHIPICVSFSFFADGELLVVDPSIIEEQIREGDMTIAMNIHKEICALSKAGGIPLEMDQIIRCSKIATTKTAEITELIQKALADDKAQRQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2Q2</accession>
    <name>A0A8H7Q2Q2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2Q2"/>
    <dbReference type="OrthoDB" id="5561579at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019727">
        <property type="entry name" value="ATP_synth_F0_fsu_mt_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10791">
        <property type="entry name" value="F1F0-ATPsyn_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2183586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="106" mass="11803" checksum="9FFBEA762568438C" modified="2022-01-19" version="1">MSSILRRAYSTKSLVPPNLAAAKTFTGNKQSATRMTELVSFYQKLPKGNAETAKPSGLIGRYKARYFDGENSSATPVIHAIFLIGGISYAIDYHFHLKHHKNVEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2Q7</accession>
    <name>A0A8H7Q2Q7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Golgi apparatus membrane protein TVP23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_000359</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TVP23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2Q7"/>
    <dbReference type="OrthoDB" id="2151161at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008564">
        <property type="entry name" value="TVP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019:SF7">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05832">
        <property type="entry name" value="DUF846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2184450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="234" mass="25698" checksum="CA18BE7FD36F59B3" modified="2022-01-19" version="1">MALQADESRVNLLATSPALQPDLEQGTPGQPGQGNMAARSNVMREYLESSSHPIALIFFIAFRLGALLTYLLGSIFTDNFTLIFVITILLLAFDFWTVKNVSGRLLVGLRWWNEIQEDGSNKWVFESANPNRAGNAKDSRLFWTILYATPVLWVLLAFTCIFTFKFAWLVIVVVAIILNLANVYGYTQCDKDAKRKWATGLAAQSAFGSLGGTMGGFAGKMFSSGVSGLFSSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q306</accession>
    <name>A0A8H7Q306_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3beta-hydroxysteroid 3-dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.270</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_000925</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="6">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.270" evidence="8"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q306"/>
    <dbReference type="OrthoDB" id="9989144at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000253">
        <property type="term" value="F:3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051593">
        <property type="entry name" value="Ergosterol_Biosynth_ERG27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647:SF1">
        <property type="entry name" value="3-KETO-STEROID REDUCTASE ERG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647">
        <property type="entry name" value="DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0752">Steroid biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2185012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="339" mass="37943" checksum="4366C853311F3B9B" modified="2022-01-19" version="1">MPIERKVAVVTGANSGVGYGIAERLLEWDCDNLIVVLACRNEARAMVAWQSLLQEYPKAKLDILIIDLSNCSSVLKACKRLYERYKRIDYLYCNAGLLSASGIKWGEVVYLFLKNPVSFIESSDATQQIVGEVNEDGVGLVFACNVLGHYVMIRELEPLLKASGEGRIIWTSSSTASSHTFDLDDWQGIKALEPYESSKWATNLIAFKMNDRFKAENLPITSIMTSPGVVASNIANLPAWVKRVRRMVHYAFRFGGLTSQNITSYNGAVSNVYCAQQPKEKLDPSKCYASCTDRWGYSFVDEHGIKNYSEDNAQAVIDKCEAIYQDWKKTSENTTNDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3H7</accession>
    <name>A0A8H7Q3H7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_002226</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12 7">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3H7"/>
    <dbReference type="OrthoDB" id="2020758at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02662">
        <property type="entry name" value="Peptidase_C19F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="135"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2185789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="639" mass="71817" checksum="F98A2246C38D4DF5" modified="2022-01-19" version="1">MLQAITVQRLQALLIDLIFTFELIFGLISFITVFLTFFPSYYYLIYDIVETTLVPVFQFVYTRCNLKYTWACLRSGGRAVVTVKRVTFRLIGGNNFLTGFNWNYAKASENPPPKLNIIEGPCMKDVDMSMSIFVHGIVNTGNSCFLNSVLQALSSLEHLQPFLYRLTQSANPSDLPFATALRQTLLSLSTPIAHKSAIQPKELVKAISRHHHVINHEQQDAQELFQIISSSLEAEQQKTRKVQSPSAGLRDLLLNGPSANIIPAKRQAATAETLRNPFNGLLASRLSCSMCGYTEAIRHFSFDNIQLTLPNSYTCPLDDSLSNFIAMETLEDVNCRSCSLKATAERLQKQLDAAEITEFVDITKMRKTLHLIEERISSNRIEEPIDPDIQLTKVLSQKSTKQVMFAKPPKCLCLHISRSAFHPSGAVYKNTCQVTFPETLDLTPYCTNSDLKVNPDMPMSSPSDQSSGTDTLQNKYQYKLMSTIVHYGSHNFGHFIAYKRRLEQCGCQSCINTRHTILDKSTTPTQHDWYRLSDEKVDTCSVQDVLKANPYMLIYELIEDEPSEPELPVVEPLQPPFTNININPTPIFKKSSLHTQITNSSIHKMSMSKTVSATIQATALSGSKIRLPADSFESGIQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3J0</accession>
    <name>A0A8H7Q3J0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DIS3-like exonuclease 2</fullName>
            <ecNumber evidence="5">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_000563</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNR ribonuclease family. DIS3L2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="5"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3J0"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990074">
        <property type="term" value="P:polyuridylation-dependent mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000002">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03045">
        <property type="entry name" value="DIS3L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028591">
        <property type="entry name" value="DIS3L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041093">
        <property type="entry name" value="Dis3l2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17877">
        <property type="entry name" value="Dis3l2_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNB" evidence="7">
        <location>
            <begin position="560"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="171"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1040"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1050"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1068"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="572"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="581"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2184650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1119" mass="126771" checksum="255093A3FF1AF93B" modified="2022-01-19" version="1">MIHDNEQTNVVEPAKSLIEPQHVPDLPSSDKQRLKQAPNPIAAKKCTNTHTEGSGTLKQQSNAKQHRERKHNNRSQNSTNTTGRGRHSTTQKDKVTGELPSVNINLPRRVQPVRTSEEFEALDSWRSTQKKSEITNESQRPVRSRAPLSELTKKKILNIIGEGRVLTPKYKETKQDEAIHKSSEPSKKTNEHQDVERDTAGKRMTGTNTPDKSDVKPKHVHKHHHKVDAANKSTVNTLKNTSNSKGTDKARGGSESDDWRAKSNIPATPVKPIRKHHPDDSHSENKRQLFARYYNDVEVIRLLESKKLYKGSIRINKRNRQDAYVTSPDLDYDIYIHSAANRNRALEGDIVAVQLKDVDQVWEVKKKKDEKNAENKKERNFSSNNEEQRQVEIIPQKIEVEEESDDEDRNKPKYCGVVVAILDRSLEPIVTGILSLDRPGNGPPKNGKSLPAPKTVWLKPTDMRMPLIAIPIAQCPADFATDEAKYKKKIFIVRILSWPITQQHPWGMLVKELGNVGELAIEAKALLAEHNVKDSDFPIPAMRNLPETPWQIPEKEYKSRRDLRFHRIFTIDPITAKDLDDAVHITDKGDGTYEVGVHIADVSYFIPSKSALDTEALNRGTSVYLVDRVIPMLPSLLCEKLCSLNPGVERLAFSVIWQMDKEGKILDTWFGRTIIKSCAKLAYEHAQQVIEGGSLSKEIEVHAHGASEIEKDIMDLYHISLHLRKARFANGALSMNSVKLSFDLDDEGKPTGVHVYQQKDANRLIEEFMLSANISVAKKIASHYPEQALLRRHAPPIERRLEEFLIQAESYGYVIDASSAGALQASFNEIDSDEVRNTLLLLAIKPMQRAKYFCTGTLDIAKYLHYALNVPMYTHFTSPIRRFADVVVHRQLEAALNGADEFPLDTKAISKIAEQCNIKKDGAKNAQDASIKLYLAEYIHRETELHGPIYREATVIRVLEECYEVFVPEYGLEQRLYLDRMALKKSTHDPANDSIILEWQESANEMKTVVDDSIKSLQFNDDDIDMDKVMNELSGQVQNMNKESKKLPETDQQTRVSSSKQTDQNDVSSRKQNEDEVKQGEPIKQVIKIFGKVQVRIDANMERTPPIINLHAVKPSCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3J8</accession>
    <name>A0A8H7Q3J8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Haloacid dehalogenase-like hydrolase domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_000308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3J8"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16415">
        <property type="entry name" value="HAD_dREG-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.720">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051828">
        <property type="entry name" value="HAD-like_hydrolase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011949">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044924">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02252">
        <property type="entry name" value="DREG-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191:SF2">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2184399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="28075" checksum="C340351286D38061" modified="2022-01-19" version="1">MTSRIRLITFDAYNTIFKPKGGISAQYEMEAKKLGIVVSKDAISKSFRPAMKTQLQKYPLYGISQGLTPRIWWEQVVRSTFVKAGATDKGKYKQKSQFTSADGYEVFGDVHSTLQELKSRKISLGVISNSDERVAQVIESLKLASYFDFVLTSSMARYEKPAKEVFDQALALGSKKQDLQASEALHIGDDIKSDYFGARNAGWHSLLLRRDKLSYEEPITSLPGDSENLPVEITYMKELLHYIKAPNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3K9</accession>
    <name>A0A8H7Q3K9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3K9"/>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948:SF21">
        <property type="entry name" value="DNAJ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="6"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2184680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="202" mass="22581" checksum="93697F3F0C51BBD7" modified="2022-01-19" version="1">MSNFPNYYTVLQIPETATTEDIREAYKKQALLTHPDRLPETANAEQRRAATEQFQLVADAYHVLVDRTRRRQYDEARSKRRATGEQEAFMRDHERADAHDVFGGVFEELLRPEVEHPTIIWQALGAGAGAVMGFILANFGGAVAGGVAGRYLGRIRDRKGVSVYTAFERLTGSQRREILTALLSRFVSHISQPGGPSGSMKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3Q5</accession>
    <name>A0A8H7Q3Q5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JAB1/MPN/MOV34 metalloenzyme domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3Q5"/>
    <dbReference type="OrthoDB" id="446074at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JAB1/MPN/MOV34 metalloenzyme" evidence="1">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="300" mass="33846" checksum="20405FA8965C549E" modified="2022-01-19" version="1">MPALSKVTITANVFHVMASHAASTEKEEIIGVLLGNWQEKNTSNPFSRDQAVAVVEAVCILTRSDKRKDRVEISPLQLHLAVVEAEKVEKELGRKICVVGWPSSYHCVSVSYRHVLNVRTQLSQQLMDERFFGLIVSCFDADADHTQRLQITCFQSNDDPERGPVQLKIPLQILPDLSMEKHTTQSIIDISQKIYEEQVKEFSLSSQRVQYQGKSEGTEENAMIVDTNPSNGEQSLPQKLSELYNSGVYGQSITSLVDKLIIPATELAKQRHAMNLLEIKRLESLRDARSRDENSFEHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q408</accession>
    <name>A0A8H7Q408_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_000816</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q408"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000008">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF107">
        <property type="entry name" value="CHOLINE_CARNITINE ACYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0440">LIM domain</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="212"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="272"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="330"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="393"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="90"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2184903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1114" mass="123880" checksum="B4E975C51D9F7D8C" modified="2022-01-19" version="1">MTRDELNKYLKGLPASPASQNPPSLAKDIQQTPASPTGAERRTSSNVLRGPRPPTISSPRAGSPTTSNPTANSIDDVKADLTYPFERKLNLNDRNSVTISTKKLTDAVGTTRPDAKPSPPVKAKPANLTRKPSAGRPDPFEASLSRGKPLPPATKPSVTIPSKADANPKPETPKPFSPPATENQSASAPKPFSPPTSTNQKVSVPNPLYSSIKCGGCEKAISGVVINAMGKRWHANCFKCKQCGENLEHMAFFEKDGFPYCGLDYHEQFSLRCDYCGTPIEEKSINALGKHYHEGHFFCRECGNPFDEGGFMVHDGHPYCEKDYLKKFGQKCMGCGDYISGEFLNALGGDWHKHCFVCTECKEPFDSETFYVKNNKPFCQRHYKSAGTIKTSSICAACGDYIEGRAASALNQKWHPNHFNCVSCGKELSANVPGMWQDNGKAEPVCKMCARRLRSVPGELLVWSHVCHPFIHNGICQVSALNHHAITQYFKLASYTSLFHFSSARRTITTFANQSKIPRLPIPTLQETTELYKRSLLPLLSKQDYERASAAVADFVRPGSLGEKLQERLHALDKKEPESWLDEIWLNKAYLEYREPTLINVNWWNQFVDPPSGLGTSPGAGRVSDMQLDRASYFLSQLAHFNDMINKEQVPAEVTRAGPMCMNQLKKQFGANRIPDEPRDRIMTPWPTTAKHASVIYKDQVFSVQIIGDSGEVAPVKQLREQLVKLVQQVDSIPQSELQAPIGLMTSEHRDTWTKVRKSMEKDSINASNFKDIDESLFALCLDDYSSDLDMDKSHRNIFHGEKARNRWFDKAMQFIVENNGRAGANGEHSPADAVIPGSMFTEILKREEQASLANNSSKSVQLSPPKHLVWNIDSSVGDALKMAENNASKMIDNLTSVLLHYNEFGSDFLKRVKCSPDGFLQMSYQLAYYRQHGEPCATYESASTRLFKLGRTETVRSCSVDTVAFTKAWDDKDVKLADKIALFQKAIGTQMEYMKAASNGKYQCCRGVDRHLLGLRCMMTAEEAANAAIFKDPSYVASMYFKLSTSNTSPGDYSWGGFGPVVPEGYGSNYAIGKERIRLSITNWKTAPEADSVAFRKTLKTVFNDLAEALERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q422</accession>
    <name>A0A8H7Q422_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein UsgS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q422"/>
    <dbReference type="OrthoDB" id="10041630at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38421:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38421">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN USGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="37554" checksum="EEAC21B84CA9DF5D" modified="2022-01-19" version="1">MPWRPEAVLHGVQYAIEGCLVVGQNPQLRKERYLQVFGYLLIASISLYALSKVLILFPLQIVRFIAFLISVLGRYDNSKVDAFLISVSRYIRDGLVSLPFVGLLFMRYLYPKPIDQLFMESLRYVDTQSPKQPYAPALAGRSFRIDYWANLRQYLWRSFKKARIGIVVYLLSLMPLIGRFILPAAGAYTVYRSLGRNQAIVVGVCFLLLPQPITKTIMRALFEMRALMRELLEPYFERVALNSKQRRKWFKRREDILLGYSAVAYALSRIPFLGVIGYGVAQAASSYLLVQLDDPPTLDMSVTELIDGKYKKSSKPATTAEETQHKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4C2</accession>
    <name>A0A8H7Q4C2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4C2"/>
    <dbReference type="OrthoDB" id="2287482at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2185702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="432" mass="48954" checksum="BD24EDEEBC46C2F4" modified="2022-01-19" version="1">MSTQSLTPPMAIPHHRSANDYEAGSVSSHNSLSASPTSTSSSQSTTSYRELVKQMTAQAPKPYGAIPPLIGRNKRKKKQKDETTVSNNHTPEDIRAVATRMANQNEQNAAHKPPLMRSMSHVENWVAVDSKESLPDEEELEQRPSALRNFLSADFLTEVLPLHVPPPPLSDPESIKQQEEIAKLADTLKQTRVQSSASHQTEVSIDRAYPDSKRKPPLVLRKVRSMNDEDARWQETRTTSMAKLLQPKKLDARETKNQKRNNVTHHNIGRRHSLTSFPKVSPSPGLKPPVYPSMPTPSVVVEDDSWFTRLKRSFSGKKKDTNRKLIPMPPPPKRPNSQRRRSEATTQPRFNPATNTYMRDTRSNSDHLRMITAELNMMRARKLLSPLKPRGFLPRRRDVFLLGDIAKRPSPLCNGQTLENMEEEEEEEQDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4E6</accession>
    <name>A0A8H7Q4E6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Developmentally-regulated GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_002737</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4E6"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17231">
        <property type="entry name" value="TGS_DRG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000016">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="63"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="288"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2186299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="40841" checksum="E5AA2B34E19B8E1D" modified="2022-01-19" version="1">MGILEKIQDIENEIRRTQKNKATEYHLGLLKAKLAKYRVQLLEGAKTKSEKGEGFDVMKSGDARVALVGFPSVGKSTILSKLTKTESVAASYEFTTLTCIPGKIEYKGAQIQLLDLPGIIEGASQGKGRGRQVIAVARTADIVLMMLDATKSEQQKAQLERELETVGIRLNQGKPNVAFKVKTGGGITINATVKLTKISEKMVQHILHDYKIFNADVLIREDITVDQFIDVVLGNRKYLTCVYCYNKIDQITIEEVDRLARQDHTVVVSCEQDLNLDYLVEQLWKHLNLLRVYTKKRGELPDFEDGLIIRNGATIEHVCHAIHRTLVSDFKYALVWGASAKHNPQRVGLHHVVLNEDVIQVVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4S3</accession>
    <name>A0A8H7Q4S3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4S3"/>
    <dbReference type="OrthoDB" id="76105at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000004">
        <property type="entry name" value="rRNA-processing protein FCF1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="7">
        <location>
            <begin position="65"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2185942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="195" mass="22722" checksum="7C2F2C3813492B74" modified="2022-01-19" version="1">MGKARKTRKFAQVKRILNPNDNRLKENQEKQKKKEEEKKKEVVRHIPQVASSLFFKYNAALGPPYHVLVDTNFINFSIQNKLELVKSMMDCLLAKSIPCITDCVLAELEKLGPKYRIALKIARDPRFERLPCSHKGTYADDCLVQRIMQHKCYIVATCDRDLKRRIRKVPGIPIMYISSRKYVIERLPELGTNTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4W6</accession>
    <name>A0A8H7Q4W6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4W6"/>
    <dbReference type="OrthoDB" id="2285780at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.700">
        <property type="entry name" value="SLA1 homology domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007131">
        <property type="entry name" value="SHD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03983">
        <property type="entry name" value="SHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="202"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2186002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="560" mass="61399" checksum="1A14341AE7E583AD" modified="2022-01-19" version="1">MTSELRVWHGADGKYTVEATFAGIFQKNKVKLLKANGGTVALPLERLCQEDRDYVKQMSSQSAPSSTTNAQSSPVSRPPPQPHTERPSVPPVLRDKSTILAYARMDNKGSTGLASFLRETASSKSPAPLGSSNSSPPSSLDLTHSDASLIAAVDQLAVASPSSSTSLSTAGKEKRSYAPLPNPAYAPKPNPLYKKLGAVAQRLTLLTLPPFVLAQICQQLDVRSILHLSTRVNKSLAAVLNNPQTKAYGYITFAREYHYLVDHPFVLALANHLKRKNLIQNVHTIVFDSTKVQELTIMYAFEYFVGLRHLSIKSCWDTHSYPLANLLARRNASKGADRLRLPHLRSVEFGKILRRGEVPGGYLVVKSESYGQDIGLIGLALRGLAGHDIKFDTYLCGTCDRGAAKPTFDCSFCGPVQLVKCWSCAPKCERCQTRACGLSSCNRIFRLNTKSPCGRCREPFPVCNQPSCPANRAGPICKTLIFVLGVDWFHVQETTLSSVWEDVEHSGVYLVAVLTKVVWTSAPVDRTEEYADDAVPHAKSVVAMNFVQCAYDDMPQSVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q591</accession>
    <name>A0A8H7Q591_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">snRNA-activating protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_000849</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNAPC3/SRD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q591"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003681">
        <property type="term" value="F:bent DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022042">
        <property type="entry name" value="snRNA-activating_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421:SF16">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12251">
        <property type="entry name" value="SNAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="70"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="171"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="211"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="241"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2184936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="60187" checksum="8E6DE0A01DAE1B8D" modified="2022-01-19" version="1">MNVKDYEGGSDPIKISEFRNKMQEVASPFSNPYLASLKVAATSNRRTEIPDDLKPSSEFFRDATLFSLLREYRHSQGPQRKNHHKNRKAKTDDNDDTDDISKETAKKTSVKKSQAKDVMPGRLIHEEDEDRDISNPHVPKKRQYLSSNKTPAIILNAKKFKKETTYRVNSINNEVTDEAESSQSNRTIENHSDQSNETVNASPMNVEVESESSSLTMLALPPTSSKPVIHSAPDSVSVNKDEEEVDELSDDSVEDESEMSQADEDEEDEEDDENASENNYIAPPDNPRIAKTSLETRYLEMAKRLDNSRLSTLRKPSASGKHVRVKDGEVVLAVAIYQEKHPTRKLQEFNVLGSQTLASLRDAITCGSDLWMDAEKTKTGRKERKITASELQRLRGLKKQYPSFFFINGCFYSDTRNKNLKGRVDDPCDAIIEWVNENDRYTQEGLGLFRKEDMQTAKFEDLEIRLNYPYLYCHQDVCKHVLIFKDLWLHGYRDELNITDYPLLTFQCRMRRNKCQMCQVWPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q757</accession>
    <name>A0A8H7Q757_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Macrophage erythroblast attacher</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_002424</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FYV10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q757"/>
    <dbReference type="OrthoDB" id="1933455at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16659">
        <property type="entry name" value="RING-Ubox_Emp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="9">
        <location>
            <begin position="159"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="10">
        <location>
            <begin position="311"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="7">
        <location>
            <begin position="311"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="25"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2185986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="45459" checksum="CBD8FB1FB0F308AD" modified="2022-01-19" version="1">MNKIKPEQLLELEQPFIKVPNEQLKKTLRNQTKYLEKEITNINDKIEDCVKKAKADRISIDQATTIIDELLVRLRKLGKKLGDIKKEEALYTTRTKLRLDHLKETSQVAPTDKEALTRWSKLRLDRVLVDYMLRKGFNETAKKMAEDSNISEMVDVELFTQSAKIEDALKRHSCTECLQWCSDNRNSLKKLKSTLEFNLRLQEYVELVRLGKKTEAIQYVQKHLSSWSESHLRQLQQAMALLAFPNDTLCEPYKGLYDPKRWKLLIDQFKADNFALCCLTSQPLLSITLQAGLSALKTSQCQQHEDKNLNCPVCDKNTLGALAQSLPLSHHVNSSIVCRLSGKKIDENNPPMLLPNGRVYSLQALEDMASKNDGYITCPRTGDTFELIETRKLYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q7M1</accession>
    <name>A0A8H7Q7M1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q7M1"/>
    <dbReference type="OrthoDB" id="5344169at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="400"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2186241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="531" mass="58264" checksum="9E57EF95A4386F9D" modified="2022-01-19" version="1">MNQTDDQRQVAHLVSSGGARTLDNDGQNVTDLFDLSNNINYLFSEGSGQNYSTMVPGSGMQSYTYGTSGSTNNTHQQANMSAAMESFSARAQLEDMHKVPSTSTARDLYTNKEDILTPLMSPARTPSFPGQHETNHLMNNETHFSPLASPAMIPQNDAANNVNHTEQLPEYMSISAESMQEHYRRLEEAKLALEEQLWELKSKQPTPINNNNKNPRKRPSTSNSTAEIQSPLHGTMNNSSAMAHQSYSSPHPSPQVSEVIHNYSRMSPATPASLMNMTISPSPSSSKKNRKRNSSVKATNISMPPPPIPSPSIQPMSSSRSAHSTPPSLKPRLPSVSASPRTLKPLLTSPTMTPTFGSSASADEAARILAAKSNYQNLREGKTAALGINFSPGIHSGIEIRRSAHKAAEQKRRDNLKEWFDRIRIELEEGFFDSMPHLTEAENAEMKQDEASKNEDSGSTSDAEGDGNNTKQGENEEGAAGSNAGGNNSKQQPMSKVLLLQYSYEYILKLKSDLRERDDKIDNLEAELSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U6M1</accession>
    <name>A0A8H7U6M1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcium channel YVC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_002958</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U6M1"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF1">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="491"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="520"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="745"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="3">
        <location>
            <begin position="306"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="476"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2171336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="870" mass="99246" checksum="B9DDDE2EAA2DD562" modified="2022-01-19" version="1">MVTIVESDSDEGTTRSQHNSKPYSSRSSGPRRKSAAGRRLSMRLPTLVALLFMTFMFARITKRCESSCQNNGKVQVGMKENSIIKGNCKVWIQYQSHAEPFRLTFGCDKTWATTKHVIKDKIQSNADKPLTGPLVLLHPTLGKVDQSTKVGAEYHSQVRRPLIAFIDEPDDPYVVLYRILSDRFTNDDVNTMRKTLCQSSFEVSSWPSSDSNTQDRLASAYRYVFKRPLALKQIHWKLVPDLPLFRSTLVMDHNEAEECGEHAPLLSPASNLFPKSRDITDAIERLILLVTIRLPKFAVVERDDLEDAVVNDKFAEVARKACDINRDVLIFVALKAMERFQIQSQGSPRWSELLETRASICESLAHKFIRLFDRENTEVFAAAIMQKHDLKLASDQSAVELAVQLHASKILLEPKVQRVIHDVWNGHLLPIDYKEGRVYFKTNTAMARMRNGFFDPAKIHVPKYANAIETFITILFLVLYTIVINDGRSHVPTVLEWVMYLFVLGDVLDDIRDIYNTGMFHYYSFWACTNTLTHLVFIASFILRMIAMSHTGSEKDMLNNTSLDVLSVVSILLWFRVLSVVCNTWRYFGSYTIIVQSMLSDALMFFFLLIWVIFGFFQAFIALRTENTAQDNDFSEIAALLMRGYLMAPDFDKAEMFHGEIGEPLFYAYIFLVSVVLQSFLTSVFSDSFSRISEDAKAQYLSNFAYRVITAVDSRKALPPPFNLIEIVCLGLPYLVLKKKNYEKLRYYFLMVLFCIPLLIVTFHEKMLLQLDNARADDSLSDDDGNMNEEQDFTTANDEHVKGLKDLVGQENLEQVVTLAASTLKSSKESDRSSASGNEMLHSDIKRVVKILDTINDRLQRLESNAQTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U725</accession>
    <name>A0A8H7U725_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_000216</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U725"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="25"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2172866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="522" mass="57154" checksum="00CF333BED8BAE64" modified="2022-01-19" version="1">MTGPVNSYLVFVVFTIALLRRLLNVRRFNQQGAFQYGFHIGELNTPQSIISKCKAHDSDPDPDLPMTGFFLPPCIPMTDSTFSLVVSMLNVGGLIGALLAPKFSDRYGRRLTLFGNTGLLFLGSLSMGVANNLYVLLWGRFLAGVGSGIITVLCSTYIAECVPDNLRGIFGVCNQLGIVTGILVAQVMGMFLSTIPGWRYILLTGAVLALVQASLLPFCVESPRYLAAKPGGYNAAKLSLAKLRGSEYVEDEINGWRKDWAEEESEQQQLLENIDEDDTERQPVQPVSLSKSQNVTFFSFLISPMYRKALAILLLLHITQQFSGINAVIFYSTSIMAPIMPQYSDKITVFISLINVTMTLVSGYLMDRLGRRSLFLYSAGIMAGVTVVLAWSMDTNVWPGLSAFAIVGFVAAFAVGLGPIPFLMIPELVDTQAVSSAGSVALATNWIGNFVVSAGFLIVRNALGGGGKVFYVFAIILVIVWYIGYRILPETKGRSVEEVVRSNWAVNHHTEEHSHERLSHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U767</accession>
    <name>A0A8H7U767_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amine oxidase</fullName>
            <ecNumber evidence="4">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_004675</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U767"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF313">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034551624" description="Amine oxidase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="6">
        <location>
            <begin position="36"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="57"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2173301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="497" mass="55857" checksum="AC9D5AA0C42EE131" modified="2022-01-19" version="1">MKFLSLATISAFALAVAAAPANTKTKAKVAILGGGVSGISAAKNLVAQGITDFVIVEARDELGGRAHDIPFAGIRVEKGCNWVQGLGTNPINQLAKKWGLKTVTDNSDNVEFRDNHGLINATKEYNEFSDALDAINDLAVKRQKNHEVDISARTAFKLVGWNPLTSVEQAVEYYGFDWEFAEDPDVTSNYYAEVNNDSYDGNFGKDSDGNNFVVDQRGFKHIFLQEAKQFLKPNDPRLLLKTTVKNIKYSDSGVTISTKEGGVIEADYAISTFSIGVLQNDDVTWTPELPDWKRVGLFGFHMATYLKLFLAWDKPFWDINKEYVVYADPDNRGYYNSWQNLIAPGFFPQNTTSNVFFVTVTQDQAYRVEALPDAEIKKEVTEVLSSMYGKKVPEPDHMYVPRWHSDPLYRGTYSNWPIGELDQHHINMKAPVKRVWFTGEAMSKDYFGFLQGAWIDGGETGDNVAQCIKKSCPKQPYYPTIKLANEKTSFTKRQEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7C9</accession>
    <name>A0A8H7U7C9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor 3B subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pre-mRNA-splicing factor SF3b 155 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Spliceosome-associated protein 155</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_005246</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7C9"/>
    <dbReference type="OrthoDB" id="438939at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000303">
        <property type="entry name" value="splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000810">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000088">
        <property type="entry name" value="Splicing factor 3b, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Splicing factor 3B subunit 1" evidence="12">
        <location>
            <begin position="275"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="13">
        <location>
            <begin position="1047"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="121"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2173826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1265" mass="142401" checksum="A9C8F46BAC45419B" modified="2022-01-19" version="1">MADGMLDKSTDLSNSPVLLNDNMIPSDIENEIKAAQAKRAKFKDGPPPITDGANKDDRVAMSGVSFDTDIYGEGNKFEGYATSLPVNDDMEEDHEDDTEYQKASRRLNSYTAPKELMSEIAAEGGEEVDPFEGTRKKNIAERESEYHARRFKRQLSPGRIDAFSGKGDSEESRSYAEVMREAELDREEERVKAAIIRKKREEEEQAKEAAARGETTQQAAPPKKKRRWDVATPAPEQPSSSSDWSSDDSASVPKGRWDETPRTSVSGDSDVDATPKRRNRWDETPVADQGSAWDATPKAGGKRSRWDETPVGANGVTATPVGGLGMVTPTPSQMVPMTPEAMNAFRWERELDVRNRPLSDEDLDAMFPTTGYKILDPPAGYQPIRTPARKLMATPTPMDAGFMMQEETRGQMYDLPTEVPGMENLPFFKQEDMQHFGKLLDDKDEAELTVEELMERKIMRLLLRIKNGTPPMRKVALRQITDKARDFGPGPLFNQILPLLMSPTLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPLLIDEDYYARVEGREIISNLSKAAGLPTMITTMRPDIDHADEYVRNTTARAFSVVASALGIPALLPFLKAVCRSKKSWQARHTGIKIVQQIAILLGCAVLPQLKNLVEAIGHGLEDEQQKVRTITALAIAALAEAAAPYGIESFDSVLKPLWTGIRMHRGKGLAAFLKAIGYIIPLMDDEYANYYTKEVMIILIREFQSPDEEMKKIVLKVVKQCAATDGVQPQYIKEEILPEFFKHFWVRRMALDRRNYRQVVETTVELANKVGVTEIVSRIVEDLKDESEPYRKMVMETIEKVIANLGSADIDPRLEEVLIDGILYAFQEQTVEDVVMLNGFGTVVNALGMRVKPYLQQICYTILWRLNNKSAKVRQQAADLISRIAVVMRTCGEEKLMSQLGQILYEYLGEEYPEVLGSILGALKSIVNVIGMASMTPPIKDLLPRLTPILKNRHEKVQENCIDLVGRIADRGAEYVSAREWMRICFELLDLLKAHKMGIRRASVNTFGYIAKAIGPQDVLATLLNNLKVQERQNRVCTTVAIAIVAETCAPFTVLPALMNEYRVPELNVQNGVLKSLTFIFEYIGEMGKDYIDAVAPLLEDALIDRDLVHRQTACVVVKHMALGVAGLGCEEPLRHLLNYVWPNIFETSPHVINAVMEAIEGLRVALGPSTILQYVLQGLFHPARRVREVYWKIYNTLYIGAQDSLVPFYPRIENDADHPYQRYELDYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7V5</accession>
    <name>A0A8H7U7V5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7V5"/>
    <dbReference type="OrthoDB" id="2095854at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2174891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="90" mass="10125" checksum="9D4EA8397C818348" modified="2022-01-19" version="1">MQQNNQEINSHPLLQRLSANEDPKAKQSKTMDIPNNSQSEQSAPLSCGYSPPGNHQQHWDCYPGMIRQIENQGSPKNVSDLHDLENARSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U837</accession>
    <name>A0A8H7U837_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ca3427-like PBP 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_009118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein SsuA/TauA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U837"/>
    <dbReference type="OrthoDB" id="1363at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd13637">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054364">
        <property type="entry name" value="Ca3427-like_PBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024">
        <property type="entry name" value="ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024:SF47">
        <property type="entry name" value="TAURINE-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22384">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ca3427-like PBP 2" evidence="4">
        <location>
            <begin position="87"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2171457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="299" mass="32866" checksum="EB320F673A16452F" modified="2022-01-19" version="1">MAIKIGYVPEHFSTPLLMSRDNGYFKEAGVDVELVCCPGGTGEMTSKLKDGTINVAVALTEGLTAGIANGQDWYKIVGTYVSAPLCWALSAGANSKHNSVETLNHTDVAISRFGSGSHIMAFVLADQQGWLKSDSKENPPFTFSALSNFKAMRDAVNAGTSDFFMWETFTTKPYHDSGEIKRIGQITPPWPAFCFAASTSLLDSDEQGLQKTLETINKATKLFMEQKDKESVEHIVRVLDYQEADVREWFKTVSYESNLRDVSRKALDTTVETLIKAGVIEKPTEASNLIDERVANLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8L6</accession>
    <name>A0A8H7U8L6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_005369</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8L6"/>
    <dbReference type="OrthoDB" id="3919494at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071846">
        <property type="term" value="P:actin filament debranching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11283">
        <property type="entry name" value="ADF_GMF-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000026">
        <property type="entry name" value="Glia maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF2">
        <property type="entry name" value="GLIA MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001788">
        <property type="entry name" value="GMF-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="5">
        <location>
            <begin position="9"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2176136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="144" mass="16866" checksum="A94F739011FE094E" modified="2022-01-19" version="1">MVISATRSMLSMQYDDLVQKLKDFRFKKFSSGNAAFVLKVDKKNLKVVEDEEHDDISLEDLVEELPENAPRFIILSYELKHKDGRNSFPLVFIYWSPKDVNPQLHMLYATAKTYLQEKIDVTRGFDIRDTEDLTDEFLQSQLMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8N1</accession>
    <name>A0A8H7U8N1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8N1"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF8">
        <property type="entry name" value="NUCLEAR MRNA EXPORT PROTEIN THP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="1">
        <location>
            <begin position="217"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="450" mass="51994" checksum="26CBD2952271BD1B" modified="2022-01-19" version="1">MSTVTAYLQQVRSAIDYKNAPTLCQLLQFYDNDPNVQALRMELAQGVNGKAIVENIFGDHSNALKNFLSAYLELVQHLQDPDALAVYDRYSAMFSMYLVQFSSPDSNWQVPLFKQLASMLVQLAFRVDKMTGFAGSNKDKKLDDATRLLSKCFNIAISDRNDGGPFEQSKKQSVLHVTNLAFKLYFKLRQIRMCRTFISHLAKENIQIDMFPKSQQVTYRYYLGRYYLFESQVRKAERELDIAFKKCTRYATKNKRLILIYLISARMVLGIFPRPELLAKYNLMDKYHSLCIAIKQGNLAGYQYHLERHMPTFLQEGTYIMLKERVKVVIWRCLFRKVYVVLREPGKTPILPFSQCLIALRFSSGDQTYDLLDIECLLVSLLDQSYLKGYLHHHKQIAVLSKNVAFPRVRDVRVITERYDDAAVEAHLAAQTVDTGLQFSTNTNFATMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8S1</accession>
    <name>A0A8H7U8S1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleotide diphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_005095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8S1"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009141">
        <property type="term" value="P:nucleoside triphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2173675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="59575" checksum="CD7EFEE368100936" modified="2022-01-19" version="1">MPKDIPLLPRGSSDRPPSYFSQNDSDEHRLTDSEEHDQLLSSTPEHEYGYTQASEQENLLGDNSTPAFLGNQSRTRRIVIFRLVIAMLLVAVFISFVSIFAPGHSAGYNPSATFFNGSHTFDATVIMVSLDGFRADYLDRNITPALHRLANEGIQAPYMNPCFPSVTFSNHWSLVTGLYPESHGIVGNEFSDPDLNDTFYYKDPARSWDSKWWFGEPIWATTVLQNKKSAVMMWPGSDTKIENTFATYHIPYSTNYTTFQKAETILNWIDLPRDQRPQMMNMYIPQVDSAGHAQGPNGKRVNETLVDMDKTIEHLIAGLEERNLYDHVHLVIVSDHGMAESNRNRLIYWDDIVPKDLMAELEEREVWPLLALRPRATAPSDTISKIYSHLLNFTQQPDNTPDKSGPQSHFQVYLRENIPEHLHYRNSHRIAPILGIPDVGWSFVTHKEYDGSKDYHPKGIHGYDNMAEEMRAIFIAKGPLFDGNYKVGEPVAPFVNIEVYGLVTKALGLSPAPNNGTLDGVFVQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U964</accession>
    <name>A0A8H7U964_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Armadillo repeat-containing protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U964"/>
    <dbReference type="OrthoDB" id="201709at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042462">
        <property type="entry name" value="ARMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46263">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46263:SF1">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="22522" checksum="EDAB906B9B06689A" modified="2022-01-19" version="1">MFQTNAHIQRRRGKDGKSRQEHLQDLANEYKKSNTIEIRLRVLSNLANFAYDPINYEWLRQAGATELFVDVLLDDTSDIQLQQIALSGLCNYALDHRTQERLAKDDAVVHQCLHYVFESNFDNRMLVTAVCLLWHICMPDNISTITTPDLKYRLEDICNSQHGNQQLKNMCRIFIDDFFLETPSQVKEISSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAP4</accession>
    <name>A0A8H7UAP4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chitin deacetylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_000081</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAP4"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF9">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034324418" description="Chitin deacetylase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="8">
        <location>
            <begin position="32"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="8">
        <location>
            <begin position="174"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="8">
        <location>
            <begin position="255"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="8">
        <location>
            <begin position="326"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="7">
        <location>
            <begin position="391"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2172734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="63964" checksum="26F9170DD077ECBF" modified="2022-01-19" version="1">MKSNLLPILSFIATVWVAQPVDASIGAHVCTTTYKVKTGDTCPSLATQAGWTESKWKQINVGVSCAPLKVGTSVCQAIKYISTTSTTKTTTAKNLAVSTTTKKTTTTTKKSTTTTKKSTTTTKKTTTTTKKSTTTTKKTTTTTKKPTTTTTTKKTTTTTKAATTTTPATTGCTQYHSVVAGDTCYDIATAAGIAESVLESYNPGINCALLQLGQSVCIAQGSVTATTTTTKTTTKATTATTTATTAVGSSFSCSKSHTIVSGDTCYDIAAAAGITEPVFESYNPGINCGLLQLGQVVCTAGSYVTGTPTKTTTATATATSTLGCTKKHLITNSDLCYTIAQNAGISTDQLLSYNKGLSCNNLKAGTSVCVAVGPGGGLFPIIPIYSCSVKNMFAVTFDDGPYKYTQELVTYLNNNGITATFFINGQNYGNIYDYKDFLIAAYKSGHQIAHHTWSHANISTLTDAQLTLEITKLEDAFLDILGVIPTYFRPPFGEYVDASLNVLQGLGYKVIVWDVDTDDWQLDGTTNYFTKEKNNFINGINGNPDVPGHISLEHDPHQSTVEQLAPWEFAYVKNLGYKATTVSECIGDDPKNWYRTKSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBV4</accession>
    <name>A0A8H7UBV4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA mismatch repair protein MutS core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007857</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBV4"/>
    <dbReference type="OrthoDB" id="2534523at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF34">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS-like N-terminal" evidence="1">
        <location>
            <begin position="126"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair protein MutS connector" evidence="2">
        <location>
            <begin position="238"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="3">
        <location>
            <begin position="399"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2177200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="65505" checksum="A73ED337B3AD392C" modified="2022-01-19" version="1" fragment="single">MHFDNHPPRVDGEKTLVTELKGQNAMLSEFRRRAFTNYRSIQTLRLRSTLQTEHCRLACRRSFMTSQYCYKRVTRGKSSDILGPPKPLDPSPKVTETDGILLNHSTGSEQLPKLRAPTGSVVLDAVREFTEKYPTCVLLMQVGDFYELYEDHASRYASQLDLKLTKKEITSGTIVDFAGFPLRSLDRYLELLVNRVKCNVALCEQYTTSSGHLKRKITRIITPGTLVEERFLDAHEYNYLLAVHVDGQNTGLAWIDMSVGDFIMQKSGLSQLQDDLARIRPREILLPAWLEQDTQHVANQIIQNFSRAAVTFRSASLFDVQAGRQNLNELFNIDKRLESPRTTVIELEPEFDAPQFSDCEIAAAQALMEYVDSTQLGTRPRLQKPIRFDAHEVLRIDNATMNSLEVLTSIREGKRADSLLGVIDCTATSAGSRLLNRWLVSPLTKVDAIEKRLDIVDYFYRRSRLLDDVRLALKSSNDAQRALQRLSLRKGQHSDLLELKWTLKSMKTIKQQIQSSLLIGNEDSFNLEPAHHPLIKLLDGLDTHDHLAEAIANAIDEEYVIAKNTKDNRDFGYVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBY3</accession>
    <name>A0A8H7UBY3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription regulator Rua1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007947</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBY3"/>
    <dbReference type="OrthoDB" id="5595379at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028012">
        <property type="entry name" value="Rua1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28125">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28125:SF3">
        <property type="entry name" value="TRANSCRIPTION REGULATOR RUA1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14616">
        <property type="entry name" value="Rua1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription regulator Rua1 C-terminal" evidence="3">
        <location>
            <begin position="549"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2177290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="651" mass="73888" checksum="37A6DA30D63639EF" modified="2022-01-19" version="1" fragment="single">MRCGDGPSLPMTEMNQFNQILRHLDYHWDDDYGMVLVAMHAYSTSTYHRQGYLYHGRYVPNSYLQIVISQTDMCLLHIVQQYFEVDNSNTDSPYFTDSTLNDLAILVTTLLALAVTISLGGLLRLGMFHMYLTILGITTAEYFTRNALKVKAGRDRCDLEAQNEDDTTEKLYGYMSGDENDDNIWRRPWSPSTDTTSSKRGYSGSIMRRIQKSWISFARHVQPLFPSDRGNYQLVNLMPSPNTNRKVPRPMRRQKQGVFSDSESDDEFGTDTIRPPMPLYDGSEEPDYSQDMGLNLEILDDLDGLIEQRPRSKNKARKILVIAKSPSKVLNAHELDSWENDFTRLPDESTHTYCSPVKVLFKDSDHETNNGLCTSVSGSSSADYTLECEETTFCFYCFNHECQCHTDSSCDSEVNVEKLDSKQPIFTSLTSDCDESSSLQEDMSSGYLYESDKDDGSEETPLNFSQQEYCPSRDSGTTAEKKMPHIIGKIPKGTECATQHKNLRSSAFNTIVPTCETVRSLLPKLSSNHIVQQVYQKDPKAVSNLARGANDYYSPRWLRGIGAKKEGLCPLCHGLWLKTKTSRFWYHMNFFHGISAVNGRPYSAPVAIRAVLKSERLQDTKTLNMHQGYCGQCGHWVDLQAKQPLLVPELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UD03</accession>
    <name>A0A8H7UD03_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_007708</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="8"/>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UD03"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="UniPathway" id="UPA00733"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="55"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2177052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="519" mass="56183" checksum="6650EBCCE765FC1A" modified="2022-01-19" version="1">MLKSISSSYLSRCLNKPLAKPAHLTKYYRMMTTAAIPDLKDPKLLRNSAFINNKWVNAKSNETFVVTDPATGKEIGKVPDMNVEETKEAISIASTAFKSWSSKTGKERHDIMKKWYDLMMANQEDLATILTWENGKSLTEARGEIVYGSSFIEWFAEEAVRAYGAVIPSNMPNQRYLTIRQPVGVVGIVTPWNFPNAMITRKVGAALAAGCTVVIKPGAETPFSALALCELAERAGIPEGVINVVTTHAHVKDIGTELCTNPIVKKISFTGSTAVGKLLMKQSSGTMKKISMELGGNAPFIVFDDADVDAAVDGAIASKFRGTGQTCVCANRLYVQKGIYPEFASRLAEKVAKFRIGHGFDKETTHGPLINEAAVKKVTSHVDDAVAKGGEVLVGGKHAGGNFYEPTVISGMTKEMLISTDETFGPVAGLFEFETEDEVLELANDTQFGLAGYFFSRDIGRIWRVAEKLEVGIVGANSGIVSNCYAPFGGVKESGMGREGSMYGLADYQNIKYINMGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UD30</accession>
    <name>A0A8H7UD30_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UD30"/>
    <dbReference type="OrthoDB" id="270318at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="253" mass="28457" checksum="38AB5457397647A8" modified="2022-01-19" version="1">MFIENYHGPRRGSSKSSTSSQSDGRLSIFAKAISQIPFSGYAALVSATFEIYGDVFPSDNNDFTLFIRAIGDGAEKPQDDESLGNLMVDYQFIPLPLPEQVMPKFFFRQAVENPNLFVKFLPAFRVDKHARYRLWECAILNALDCSFSGSSVLTKRKAERMRYIAKWLEDSPPGGVEEEKEIFKSALTDIHKRYPSGYISSVIMAKVFGLVDEYIKPGFGSLIVDDYGGSNQSASQEIRQGFRKFMEECNNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UE68</accession>
    <name>A0A8H7UE68_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UE68"/>
    <dbReference type="OrthoDB" id="2355723at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="404" mass="45007" checksum="926F0C7912A6EE4D" modified="2022-01-19" version="1">MVARQAGRTHTFYFIHPTTSKPIAFDRVNQPLLERRYKQLNDPDIWHSSHRGLSDRAHILVQDSYWPDSDAVTVDFHRMCVHAPSESGVMEKYRICRVKLDWEQEDMLKALQEQTPRDAMIREHRDRMMMMEVDRESTVDGLAFPPQSSTSSFTTSLGLSSTNPEQALEDRESAQSPLPSRRSSSMYGLARRRSMMLAAGLGNPENVMMSRRRSHQLSPNTPDVGTPAVAPTATSSDSTVYRSVRIDDDAAVQALVSRMRRAHQRSSLAQMQRSHRSTPNSGSTTQSNSPSLSPTLHSDSSNSSLWHRRLSVAAGHSSPSSTTPLRQYMDRRLSAPNNSVIRNMIMSELAAVQQQLHTPPLVASPRHRSEASGGSENDTHTEAGIATIEDASTYRPGDDSTLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFN0</accession>
    <name>A0A8H7UFN0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFN0"/>
    <dbReference type="OrthoDB" id="2210039at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2178133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="164" mass="18693" checksum="4F853A59904E15BA" modified="2022-01-19" version="1">MSIPRQSYSRQKIASRPRSMSVTHDFECRLFDSPYRSVYNDDDNIGYSSYTSYSSYNSYGYEPFPVLVMAKQQGFVFNEELLVSPVRRRSGYETLASMSKSSSSSEFDENSSRSSQDELDKFVDDDNESASFRASAAKGVGLEQQTEGVVEIKLQERDCDIWPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFS5</accession>
    <name>A0A8H7UFS5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5'-Nucleotidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_003824</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFS5"/>
    <dbReference type="OrthoDB" id="10252235at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF48">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="4">
        <location>
            <begin position="349"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="604"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="653"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2180037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="691" mass="76796" checksum="2B849FC168BF60F9" modified="2022-01-19" version="1">MSEKVSCTALHRNSVVLGFNNMSQHYRCGIIHFNDVYHVSAGNYEPVGGASRFTSAVRSSLAELQQKGYNDSFVLFSGDAFSPSTESSITRGKHMPAVLNEFGIHAAQYPDFDFGLPQLKKLINCTNFPWLLSNVLDRTSNQPPEGIQKHLVIVCKESGLRIGLIGLVEEEWIATIPSFPPELEYHDFLKAAKELSEELRDTSGPHHVDLVVALTHMRVPNDIKLSKACQGVIDLVLGGHDHFYYLSKAVNIVGENWSRQQNLGELGFDPEKENEPSDTLYVVKSGTDFRELSMLTIDVEKDQSGKCVVTAVNADRKPITSDIKVDDITEGLVQDIAKTVSTKTAYAIGYTMTALDGRSSAVRTKETTLGNITSDLMMNAYNSRIGQVDAAFCCGGTFRSDKIHGPGPVTIGDILDIFPYEDPVVVIRVTGQQLWDALENSVSEYPKQEGRFPQLAGLRIEWNPSDEPGKRLRKVYCMKHSKKSVSAFLKDSRSPFEYEPAPVQSSKERYAPENMIPLDLNEVYWIATREYMSQGYDGFTALKVDKEDTLIDDEQGVIISTLFRRFFLGLKYVNALQDSLTESHNRNERVKELVVNTALKWRQKASSGTKGGDAVVPNGGTGHQKAHHHCSTAGIRKALSGSVQGHPSCIGSESDEEEEEQVVEPQDENHWVQRWASIAPSIDGRIIEVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UG07</accession>
    <name>A0A8H7UG07_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UG07"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="98" mass="9786" checksum="021A8D3EF6C12F0A" modified="2022-01-19" version="1">MFGNSRGGYGGNRYGNGPPTRGGYCGGPPMSQYGRHSHGGYGGGPGYGGGGYGPGYGGQSQFGYGGPPPGRRGRPMFGRGPPRRRAGGPPGCVACSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGA2</accession>
    <name>A0A8H7UGA2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGA2"/>
    <dbReference type="OrthoDB" id="303107at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031213">
        <property type="term" value="C:RSF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028938">
        <property type="entry name" value="Rsf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296:SF3">
        <property type="entry name" value="DIKAR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296">
        <property type="entry name" value="REMODELING AND SPACING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="731"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="879"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="903"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2178149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="929" mass="106015" checksum="8BB1F97D2F61B788" modified="2022-01-19" version="1">MPTEEALLLKQLRNNVEFASVSQFLHTFQTALDPPRSAQRSSSQTGSRQVTPLIEEGPFDTEHFERMLLDDGERYRLEYLIIRLLKVLTRNRLVSAETWQLYLIREFYKRELETDNPFYQANYWPFPMSKTKITYEPVEPEPKDGDDDSSVLSDEEKKDEDDDDVNGDKTQDSKTSDAKDVDNVKLEEQTPEIEGPMQEEQPDPINFFDLDLDTRVHVLHILCEWQLDEPERMREHLASEDDAAHWRVDPVGYDAQGNIYWLFDDNRLYRESQAPPKKSKAKGKGKRGATKKKAPPPPPPARRGTRRGLRSAPTEEPPEEEQDIEQPVEEEDEEWMPWKMLCLTSSDWQNFPKRFENSKHRDEQRFHQYLTRDLIPQIVPILEEREKEKKLEEALSNRKRSSRIQIRDLHQQERLRQEALEYAHRQQRRMTTRQEEVAKKKEDEEQASAVNSREERLKEREQRIQQREMEKIKALSRQEEKAARDAAREQERIQKEQEKAKAKATAKAAKATEIAANPDQPPKVPKKRGPKGPRKKKVIEEEDNWLFDCLCGVKGQNLDDGTPMIACGRCGTWAHIACLAKHDPTRKSMKAWENVDYTCRHCIARAQQRQQQQPPPFQSHYTIDHEKERQAQNPHKRPWMDSPPHANPPFKFSRPEVSSYGPPQAAPPRMPVFSHHNYSSDGTAQPPRIDSGPRYQPAPYNYQNGGGQGQNGQHAYHPSGPSLPAPPPPVSQASMGSAHGSSHGPQNGPQHGSQHSPQHAPQHGPQHVPQHVPQHSPQHVPQHNPQHAPQHGPQHPPQHGYSLPHISTSTSSYPSSQLPPLQSHPPASTNNQLPHLNPILPPANNLPFGSSSVPNPLPRPQASNPLPPMTSAAPPTLPPMQQQPHAAQQQQHHQSLPYPPPSTTSYPSQSQLPSLGPMPQQQSGQPQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHJ7</accession>
    <name>A0A8H7UHJ7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHJ7"/>
    <dbReference type="OrthoDB" id="2225742at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2183320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="122" mass="13721" checksum="F0405972C81D8D82" modified="2022-01-19" version="1">MIKSTHTLTRAAYRHTSIRYASVLASIPRQPPVHWTAPIVTPAEEPITIPSNNAFHPDVIPAKAKARINLQSISNMLDVAQRLVRELQVQHQPGQAHLVEQVQAIVKEQKKLMKLLESPKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHR4</accession>
    <name>A0A8H7UHR4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHR4"/>
    <dbReference type="OrthoDB" id="2365085at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2180308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="132" mass="14919" checksum="A4C38AF77EAB94F5" modified="2022-01-19" version="1">MTVANSNTDTVENLIAFDEAIVPLMGCPASEFDQFAVEHPDIYDITANLLVGLYCEFSIKDSVRVTKIAHLKPDRIIEDVKPLQSFAPVTSSIMTCRYWQDNNIDDLLDPCTKMNNLMTFMPTQGRKRPFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UI55</accession>
    <name>A0A8H7UI55_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_007518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UI55"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF109">
        <property type="entry name" value="RIBOSOMAL LYSINE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2182587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="269" mass="30379" checksum="3D76C1B2C9C648FA" modified="2022-01-19" version="1">MPTERQLQILEERRKRREEYNSTSTSKIPLAIEGSRFPSFQFQKPLTEQDANANYFYINGTPIWLSQAASHDDHIIQDHTVRTSSSLWDCGVILAKYLERHPSSVCHKRVIELGAGKALPSIVAAALGARVVITDAKEGINAAEGVAALNNLHIHGRGHGWVESVQSLDWIDRESDMMNLQNGPFHVVLCSDVVWVEYLVPYLVQTMAELPLAVDAKILFAHQTRSTRIDNLLFEKLSEHGFVHEKIPNSELHPDFKKEAVCLMRIHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UI57</accession>
    <name>A0A8H7UI57_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">INT43_003751</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UI57"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF8">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="572"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="332"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="861"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="861"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="873"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="897"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2179964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="911" mass="102685" checksum="0F23F69884AD6578" modified="2022-01-19" version="1">MDESAYAPVHPPPSVVTTDSELSSLPVKRLQRHSDLDNLSTLQDRYARTRLNPEQSNAMMDNVMTIDTIPLTPPGRSSSEMQSPRRSLTSTKKWPLQDSRLQITIMTVQLNVPIKRPYIKLTLGGMCVMLISIAALSLTKLKFYTSSDQTFTTSVSEYQEGRWYEGFELKVTYHAQLFDTIHMDLYDHGSFFSDRHVGRAEIRLRLLDGLPEVFTSYYEIWDKKLSSNSTSAVGRRKILSANIGAIQSRIYYRYQKDEHSLIDKAPHLRAPGFYVTTSQSLVTEEQITSEFERHLRYQRERDKTGITFRKYEENNASGENNLDNYEEFEDRDYEDVDDDEINLSRPLSSKPEKKPSEATLMDDTPAEQQTAMRRSWSSMLGFGGSKVAADASASSTRTSSSATLRNVNAIGGMVDDDETLKTYPLLETLGSWATTKETNQVLRSIGKLLAAFGQGFELSHLQVLIGFTVLERFYAELPKNRTWDLVTDLGEIEPAAHFWKFSIAAYGWKGLTFIGKSTGILTNATRKHSDALSVVEYLSLPKEDLLAYEFRTGEVFRPSYFIARDRATNSIVLSIRGTMSAFDTLTDLVCEYEQWKGGFVHKGMKSSALWFFRNVAPQLIAYTNQHATSALYIVGHSLGSSTAAILTIMLLDYIEEFRKSADNNDNQDFQIKCFGYAPACGLSLELSERYKDHIQSYVFGDDVVSKMSYGSMMDVKELVIASSEAARGMSLSKVFLSGQPDDTAWKPVFEAIADCRSKCLDSLANPRLYVAGTVYQFWLDPTPSNPTRMVVERTSAKQVSREMLVRRSIFLDHLPTNFDVAFTRARESLMIHGGQQLRLSTEGKQQEGVLDESLAERRGRLSLDDKVKEEANEQQNEQQQEIAMPSAATDTTVAEAVAKDEEPPSKDSNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIA1</accession>
    <name>A0A8H7UIA1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIA1"/>
    <dbReference type="OrthoDB" id="2138242at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="534"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="575" mass="63794" checksum="D22F6482EB539AB5" modified="2022-01-19" version="1">MKVQRLHLGQADNGLPFYLYQIPTSTSSDNFKQPFYQIDVLEALFCTTGLRLLDHVPRQYFETEECYYYQGEDGKTYLLAQAIGEAAIKLNKYLLAEICKLKREDILTGVAHTLLEGVRGLARPGNYAEDEMEIALTPANKSVDVLAIKAEPESPPPNQLDNSPNERLSKRRYNNPMSVDQLVSEQVQDRAVFFSDEDSLKRRRLGMDSADRPQSARYKKSAKSEERIQNGHQRQSDPSPNSDIPTIVHPQPLPRPNNQSASTLLSKRFTQKSNKNARNLTIYTPSYAEQYALGIKSAPLHATHQNSAHSHNPHKASTDSLHPRQAHHTLAPLLSPRAPIVASQSGMRSLVNPDNMGPKSAANAGHFPSIHNSTASSPRKSEFPIPPVVPSQQLQHYQNVVPIPSLYGPKSARSTSDHTPNGVPTTSTPGTAAAATMPPKTPTTTSFASLQKQTFLQPFEHLFENIEITRTLKSTLDDQVRRSSSLLQSLQSHNSMVENMVKSHMKEIQREISEKIDQKFDEIIQRISTLEGTASSYQGSPSSSSASPALNGTKSNSVDAIRHQDILSKRKKESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIE8</accession>
    <name>A0A8H7UIE8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">W2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIE8"/>
    <dbReference type="OrthoDB" id="10250831at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071074">
        <property type="term" value="F:eukaryotic initiation factor eIF2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11561">
        <property type="entry name" value="W2_eIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000031">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.350:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF7">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="7">
        <location>
            <begin position="242"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2180968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="399" mass="44491" checksum="8A7F803E315DEDBC" modified="2022-01-19" version="1">MATVNIRRDVKDSFYRYKMPKLISKVEGKGNGIKTVIPNMTDIARSLSRPATYPTKFFGCELGAQVKCDEKNDRYIVNGAHDAEKLQVLLDGFIQKFVLCPSCQNPETDLHITKSDDIEMDCKACGARNLGDMRHKLASYIVKNPPESASKKGGKKQRKAATAQTNGTDENGIPETNMEEADEAAGSDDDIITQRINKEAAGLKLESTMGEDDWSVDTSEEAVAARMKELSVKASLLGDDDDEEGESKYEQFGQWLEENKEGTDADIIAKAEELGVLGKYKVCQVLVQCIFNENITIQIPKRVKLLRKFVNGEKHQRAVLGGIERLVGLEYKDKLLSKVPIILKKLYDADIVEEDALLKWGEKPSKRYVDKDTSKAVKKSAAPFLDWLQNASEEDSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIP1</accession>
    <name>A0A8H7UIP1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">[histone H3]-lysine(36) N-trimethyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.359</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">SET domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_000459</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60324"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:15536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.359"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.359" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIP1"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140955">
        <property type="term" value="F:histone H3K36 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19172">
        <property type="entry name" value="SET_SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.100">
        <property type="entry name" value="Set2, Rpb1 interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044437">
        <property type="entry name" value="SETD2/Set2_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042294">
        <property type="entry name" value="SETD2_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013257">
        <property type="entry name" value="SRI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038190">
        <property type="entry name" value="SRI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46711">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46711:SF1">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08236">
        <property type="entry name" value="SRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="17">
        <location>
            <begin position="240"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="15">
        <location>
            <begin position="297"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="16">
        <location>
            <begin position="421"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="856"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="172"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="661"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="751"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1031"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="751"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1037"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1075"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2184550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1113" mass="124419" checksum="1F6829E3C1694F3B" modified="2022-01-19" version="1" fragment="single">ERFATHTVIDSSEASNRLDERSDKEKRFSDQRTESYSPQANSGRNLGQSNDHQMYVETGPDRHLLRAFTSSDTVPNLRETVSDNLNDITVHTNSNGSSPWASSDVPIAAGASPVNENSWPLSQGAVNGLGLKSDDSIKTEEGERLISDRAILEPPSMDEADLAQRDLKESILHDLLPPSNGKSEDILTGLPTQESTPQSDDGDKPAFASYPCSTAEAMTTYQHITANIYKGSATGKSIAEESMPCECKYEPGLDYPEAACGDDDVCINRMMFMECMEDDCPCGRYCRNRRFQLQQYSSVDVIRTEKKGYGLRALADFESNQFIMEYIGEVIPNSEFIRRTKEYGAEGVKHFYFMTLKSDEIIDATRKGCLARFINHSCRPNCVTQKWVIGKTMRIGIFTSRDIKAGEELTFDYKFERYGAVAQPCYCGEPNCKGVIGGGNAKYSLGDQTAPDSEQSEEEAEMEALDLSAATPKTKLIKKEQIRKRMNRPLESPDEVQLFVKKMLGSVGKAKLVEKLLYRLEMTESTTSNGREILKKFVRLHGLKMLKFWLGEWKNESDIVKKVSIAFSCSFFKTYCTDTKAIQVLHVLERLPLANRNGLEDSDMFEVMKKYTEYGDEDIESRAQSLLDEWSELKSVYRIPKRVYTEQPKEVIMDTMEETHVDNQSVNETEPDHNQSQSKKRRYSSSRDFYEAPNDYYEHLPFNISLEDMEQRLRFPPVVSIPTAPKAMLAAAAASAALAAQNAMMYSNSTDQSAPTYYPNSADPSNGAAWEQADRSQLTPAISDTYSAHKDLSAYNSPRSAATLTTEDAALPTGPAAMQPYANLNRSQISRYSSPTTDVSNQPMGYTPTSSGTEYFKLPPNWKVAYSAEGSVYYYNSITNQTQWETPEEKVSSIEGVDQSQLDGLVASTIMEAERRKKLITSTPEQELGRAVKLSKPQSSTAKSDSTLKALSEVELKKEIGKVVTKYLSSKQKALWQGDKQLFKDLARKITHHIVDREAQSSRKVQTVNSALRTKIEGFIDSHGVEVVNKLKRKRRSDRDDRSHNDSKRRYSVSSRTGENDDQFEGSVSVPMDCSSPSTSQDITPMQDEGTPTLSSLHSSTASPPVRGPPGHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJZ8</accession>
    <name>A0A8H7UJZ8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_000461</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJZ8"/>
    <dbReference type="OrthoDB" id="415460at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF254">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="124"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="421"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2184552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="450" mass="50307" checksum="ED8D92BF384E51D1" modified="2022-01-19" version="1">MNFFRSKPFRRLEDEEGSTTVLFENHDDDDIELHQNPGTSGHQFVPSDDESEDDLGKSPNQGEISGDNNAISIGGNRAAWASISNLSSDRPTRPRRRQKYTAGDIVNPWKKTLYKLLEDPSSSSAAFWTNVFVSLMIFLSALTTTIETIPAFRSAETPLSIIDFISIVPYYIELLAKKDTTYEFRFTILRLFRLLRLFKSYKYSNTIVMTIEVMMVALKRSGDALSALFFFLVTSLVLFSTLLYFAERGIWDTTLETFVDASGNPSSFDSIPAAFWFVLVTITTTGYGDMVPTTFIGKLITFPAMMFGVLVRDQWLIALPSIIIGRNFTIVWEAMRRYQMTHNGELPQSIGQSSEDADASGRRDSFIDDIPHFPGIPSPSQNMANNSSNAQLAEQVAALTEMTRQNQQAIERILKLLETPSQIVPQPVTTSDYPSPGPLDAIDTKDSLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UK27</accession>
    <name>A0A8H7UK27_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial glycine transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Solute carrier family 25 member 38 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_000555</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>glycine(in) = glycine(out)</text>
            <dbReference type="Rhea" id="RHEA:70715"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UK27"/>
    <dbReference type="OrthoDB" id="1924968at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904983">
        <property type="term" value="P:glycine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03064">
        <property type="entry name" value="SLC25A38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030847">
        <property type="entry name" value="Hem25/SLC25A38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="5"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="119"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="216"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2184642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="311" mass="34208" checksum="B0D59FF8F9050C95" modified="2022-01-19" version="1">MTPKVDPALHLLGGAGSGMIACTALQPLDLIKTRLQQQRQDHLSFLREAKTKGLFVAPQKSNIYSTVRDIIRTNGPIGLWRGTFPTILRNVPGSAMYFFALAEIRSALNKSHTTGKNPLQSWDNLLAGAAARGSVGFVMMPVTVVKIRYESNFYNYKSLSEAFSSIVKNDGLRGLFAGFGATFIRDAPFAGIYLFFYEHCKTVANAWSTNNGVNVANAAVNLGSGVLAGLAATSVTQPFDMLKTRMQLKPLIYRNIWTSAKKVALEEGMVGFFDGMAVRMVRKSLNSAISWTIYEEIVRWHRDSLVDAKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7ULY1</accession>
    <name>A0A8H7ULY1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_000541</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7ULY1"/>
    <dbReference type="OrthoDB" id="5566198at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 10" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="364"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="179"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2184628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="435" mass="47651" checksum="4920E3889CB32DCE" modified="2022-01-19" version="1">MSQVTRFDTDHEDLIHDVSYNYYGKRLVTCSSDQRLKVWDFNETGNGVAKWEVNDSWKAHDCSILKVIWANPEFGQVIASCSFDRQVKIWEEQEIEPKNSQKRWAEKFRLVESRGAVQDIEFAPGNGSLRLKFTSSRIQATCAADGIVRIYEALEPTNLTQWPQMEEFEISSVNSYPPGQANSAAGNMTNNSVGGGGFGSQTQNALSGPQGLSGTGTGSAGGVQQIGGNSGRSGDVGGSYCLSWCPNRCPAPMMVVGLGKEGGARIFKHDGQNRWYPGEYLPGHEGEVHDVCWAPSMGRSYQLIATACKDRRVRIFKLIDTSTNSHTSQSMQSRTASAKNMSPTSSPGQASIGKQFKVEVLATFADHDAEVWRVEWNIEGTILSSSGDDGKVRLWKAGFDGNWRQMSEISAEPRNTNIDGSHATKLPGYAQPQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCD2</accession>
    <name>A0A8H7PCD2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCD2"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="9"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="207" mass="22154" checksum="BB640CE7BC5F1F61" modified="2022-01-19" version="1" fragment="single">LLTTVNIQIAVVYYSLYGHIGTLAKSVAKGITAAGGQADLFQVAETLPAEVLEKMHAPPRDTSVETITPAKLAEYDAFLLGIPTRYGNNVAQWRQFWDQTGGLWASGALHGKFAGIFVSTGTLGGGQEVTALNTMSTLAHHGIIYVPLGYKNTFAQFSDMNTVRGGSAWGAGTFAGADGSRQPIDVELEIAEIQGKTFYETVSKYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCP8</accession>
    <name>A0A8H7PCP8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_009153</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCP8"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044791">
        <property type="entry name" value="Beta-glucanase/XTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31062">
        <property type="entry name" value="XYLOGLUCAN ENDOTRANSGLUCOSYLASE/HYDROLASE PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="5">
        <location>
            <begin position="7"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="249"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2171492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="336" mass="37063" checksum="204DE9C307E08AD3" modified="2022-01-19" version="1">MCVNLEDHFKDPSKLVSKSQWNGDPNAAYWTSDFEPNNAKIDNGHLLLNMGLDQSKLAEGKQQGFGATVSSTRLMLYGNVTASIKSGSSSVGVVSSFITKNDLGDEIDYEWTGNMTQVQTNYYWNAQLDYTHSTKEELNTDLSTGYHQYEIRWMPEAIQWVVDGQVRRTVSKESTLNPDDKTYKFPSRPSRIQLSIWDAGQIGSNWTDGWSGGKIDWSDAKRNFQMDFEWIKIDCLTPAKDAAWPPAGYGPKVGDSKQNSTNKSVQGTQGTQGGVRDNTVPTQTPTTKTPSIIVPLALTGGLMGAMIIVGFAVSSIARRKKAAKLAMAEKAMIQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD95</accession>
    <name>A0A8H7PD95_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_008147</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD95"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2171767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="51054" checksum="70234C7CE8368CDC" modified="2022-01-19" version="1">MTDTGHSIPSLGSRRRYILGIVSLLMVVVIWVSSSFVMNVSASGGKSIFGERSYNKPFLITYVNTASFSLYLLPFLLKRKFLKKDSKESGIDRSSRPVCLVPTHHNDDIVSDEPVIQDHRAQLLSADNPVETFSESSSLMASDEEDDQLGHGVSYGSEQSDKLTIRETVKLSLTFCIIWFLANWSTNASLAYTTVGSSTILSSMSGLFTLGIGAMCGIEKISTLKVAAVFISLIGVTLVSYADSNNSSGTPIDQPEHPHNPLLGDILALMGAFFYGCYTILLKVRIQDESRMDMSLFFGFVGAFNVVLLWPCFGILHVLGIEKLELPGAGAIWGLIILNALIGTFLSDYLWLLAMLMTSPLVVTLGLSLTIPIALTGDFFYKHVVPNLQYAIGAILVIIGFLSVNMAALSEVDEAESHEGRQLVPQEDSFHPSLDIQQRLSAEHIPKSSESLHSNRSYQSLDQAGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDR0</accession>
    <name>A0A8H7PDR0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="7 19">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17 19">Alpha-IPM isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18 19">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">INT43_001510</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 19">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 19">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="7 19"/>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDR0"/>
    <dbReference type="OrthoDB" id="2279155at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000007">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000003">
        <property type="entry name" value="3-isopropylmalate dehydratase small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012235">
        <property type="entry name" value="3-IsopropMal_deHydtase_ssu/lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002458">
        <property type="entry name" value="PRK01641.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004016">
        <property type="entry name" value="PRK05478.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009116">
        <property type="entry name" value="PRK12466.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF9">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001418">
        <property type="entry name" value="ACN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11 19" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="16 19" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 19" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="15 19" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="20">
        <location>
            <begin position="12"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="21">
        <location>
            <begin position="536"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00014371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00033368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAG2172033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="763" mass="83341" checksum="81BF1AAC685E25A4" modified="2022-01-19" version="1">MPSSTQPRTLYDKVWDDHLVDQQEDGTCLIYIDRHLVHEVTSPQAFEGLRNASRKVRRPDCTLATVDHNIPTTPRKNFKNIHTFIEEADSRTQCETLEVNVKDFGLTYFGMDDDRQGIVHVIGPEQGFTLPGTTLVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLLQKKSKNMRIRVNGHLGEGITSKDVVLHIIGVIGTAGGTGCVIEFCGSALAELSMEARMSMCNMSIEAGARAGMIAPDEITFEYLKNRPLSPKGQEFEKAVAYWKTLHSDADAKYDHEVEIDAADIAPTVTWGTSPQDVVQITGVVPDPAAAQDPSRRAAMQRALDYIGLEPNTKIEDVKIDKVFIGSCTNSRIEDLRSAAQVAKGRHVAEGVYAMVVPGSGLIKKQAEKEGLDKIFIEAGFDWREAGCSMCLGMNPDQLQPRERCASTSNRNFEGRQGALGRTHLMSPAMAAAAGVTGHLIDVRKLIPSFSSSAPTKTTHPEIEDEHIAHKQQDQHDDEQADIVTDAPAGDIVHPAASAGSVPAGMPKFTTLKGYAAPLDIANVDTDMIIPKQFLKTIKRTGLRDALFFALRFDQSTGAELPDFILNQEPYRQARILVCTGPNFGCGSSREHAPWALNDFGIKCIIATSYADIFFNNCFKNGMLPIVLDQASVDAIAEDGRAGKEVEVDLVNQVVRRPDGTTIAFDVEPFRKHCLVNGLDDIGLTMQKNDKIESFEEKRTSLWPWLNGQGYKGGATRVVPVASDSAPKKKLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PE65</accession>
    <name>A0A8H7PE65_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008086</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PE65"/>
    <dbReference type="OrthoDB" id="2190219at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF1">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="7">
        <location>
            <begin position="31"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="503"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="545"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="652"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="678"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="711"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="750"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2171706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="831" mass="92066" checksum="4F3FA68EAD350B48" modified="2022-01-19" version="1">MTGITVFPGEISPFTETIAVLSGFIVIFGFVSMFVKERLFISEAFVAVVVGIIAGPLVANGINPYNWQDTDEITKQLTRCVIAIQVSKTIVLDTVMASGIELPKHYLKKEWVSMAMLLGPVMVYMWLMSGLFIWWLIPPLNYVRSKKKNRLSFSFPFSLTYHVPPIFAIFTIAFDSQLESLAIAACVTPTDPILANSVVKGRFAEKHVPAHIRNALAAESGANDGMGFPFLFLAVYLLSEPTVGEAIGKWFYLTWLFQIVLSCVIGLVVGYVARKILQWSERNRFIDKPSFLCFAIALALFLMSMTGFSGSDDLLACFVAGNAFSWDDWFRQETEEAHFQDVIDMMLNLAVFVYIGCIIPWSSFSIPELGVAPWRLVVIAILILLFRRLPIVLLLKPVLPALKTYREAFFAGWFGPMGVGAVFLSILAKEELEKVHGEKNPASVELIAPIVLFIVLSSVLVHGTTIPLFQLGKRIHTRTLSIASSHNQVSRLPKLQFGQTLSFSRDDDARSGHSRDLEMSLSRTERNTLFNTPHERPSASRNEADSSGETTMVPAESSSPEDFAAVDMTGASYSDDDDDVPDEEFLPNDDEDQTNQIYGGHGVHPADPEGTEPKNPPLPTHLQPETQPDSQRGGGSSNEMSSIRFLEPVKPRSSTQANINVERNESSVTSLRGLFSKATREERDSMRASEDSQSKRRPSHPDIQLAEGEPSAERKKWHERAGFIPKTLRGMFESPTAQSSGEAGGGEKQAPPPEPGHAPLPPKIQVWEEHHRVVIEDANDTINTIVIDKADPEWRAKAKQTVADVKQKGAEIEANTLQQEASAEEEEKFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEJ3</accession>
    <name>A0A8H7PEJ3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEJ3"/>
    <dbReference type="OrthoDB" id="5537330at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF2">
        <property type="entry name" value="PEROXISOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2172438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20268" checksum="DA5EDB97E75A9445" modified="2022-01-19" version="1">MPQVCGLASANRPSAIPSIVDTYLKQLKGTDERKKWVMMAQNALLKASFVIGMPKTINAMQKLVSVVDNETKSTLPTTPRATPPDYQAHGEAMFKKVYDKVTDRVKHNIGQSSPDLLNVILEDVYGKIMSNTELLGELETELVIITVLCPLKVPAQLKGHLYGAKNVGATDHQVAAAKAIGDAISNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEV1</accession>
    <name>A0A8H7PEV1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3">4.6.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_004932</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEV1"/>
    <dbReference type="OrthoDB" id="429626at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="entry name" value="Molybdopterin cofactor biosynthesis C (MoaC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01224_B">
        <property type="entry name" value="MoaC_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047594">
        <property type="entry name" value="MoaC_bact/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050105">
        <property type="entry name" value="MoCo_biosynth_MoaA/MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006870">
        <property type="entry name" value="PRK09364.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960:SF0">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="Molybdenum cofactor biosynthesis protein C, MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin cofactor biosynthesis C (MoaC)" evidence="6">
        <location>
            <begin position="55"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2172390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="206" mass="22540" checksum="7BEC4F0C6DF7FA3F" modified="2022-01-19" version="1">MYQKIHNLIPVPVLWQSSQTSISIPRMLFQRAQTRLYSTKPKLTHTDPDTGKAKMVSVTQKDITSRTARAEGKIMLPRPTYDLLSKTTVTKKGDVLTVAQIAGIQAAKMTSTLIPLCHPLLLSNIQVNLKLNSTSHSVDCTSLVECRGNTGVEMEALTAVNVALLTVFDMCKAAGHGMEIMGIKVISKTGGKSGDWDHSKMKEECE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEX4</accession>
    <name>A0A8H7PEX4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEX4"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2172420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="23315" checksum="1E769ECA0D6DC50C" modified="2022-01-19" version="1">MNALPSDIIAHILSMSSESTLRECMLVDRRLHTHAQKCLYTSVEFEVKTFNKFFNTISSKLQESNHSCIQWIEEFSLDVMDLQDSQKIDSDDEYSDYDDDIATVAKIAKARDIASSSEIWNQLLDLRSILESCKNLEGIHCPTNIIEERAQVFGHRLRYLIPKQLMHLLPAPIPLQRPQRPLVLPNKLFDLYTTSTNANHPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFB8</accession>
    <name>A0A8H7PFB8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_000251</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFB8"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2172901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="58216" checksum="DE9E79530BA29A0D" modified="2022-01-19" version="1">MNWEQYINNEQINKSIHKVTDALSKLNRTEVAGIAVGSLAVYYIANTFAFDPLRSIPGPLAAKLSRFYDLKTKAGGKKPEIIEELHQKYGDVVRIGPNHVSIRDPNAVKQIYGTERFLKSDFYDVFKIDGNESIFSTKSSMNHGRFRRIMGPGFSQSTLDNLEDIFMDNGILLFLDKLDKNVADKNMPANLFNEFHLLAFDVLGELAFGKSFDMVKMNSHPFTSWLKARSSIIPLLTTFPMLNKYPMLVRNFFPKANEALGKIKEFSHGTLEERAADNTTNRRDFAHILVEARNSNKKGVCLTEGECAMASVVLTIAGTDTTSNTMTFTAYLLGKNPHVEEKLYQELVKAMPSRDSVLKYKDARKESLPYLWAVIMEVTRMMPVVPVGMPRVCPKGGEVIAGKYIPEGTIVEVPVWSIHYHPDIFEDPYTFRPERWLEHGADELTKYNIAFSTGPRMCAGKNLAMMEMTLVLAHLYRRFDVKLAKPNEELQLSAQFITKPTDGQMNVVIRSRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFE4</accession>
    <name>A0A8H7PFE4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_000240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFE4"/>
    <dbReference type="OrthoDB" id="5592268at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="7">
        <location>
            <begin position="196"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2172890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="465" mass="53868" checksum="7179F481E387DBC8" modified="2022-01-19" version="1">MRPIWDLVLSYLKSPDGKTGDEETVIAYASRALHSPETRYATTHLEALALVWAVRHFRHYLAGRRFVLIIDHAGLQYVFSNPRPSNKMTRWVADLMEKRRDRIKYPSVHTLKTPSDKTLKPELSDRKNLPKCLQLKATGESEKDLQTLHCTKRCAIQAIRKERPWSRGPSLENIVGYVERVHNEGHLRNWCARVQSVTTAEFLYRQVKCQHGLPQYILTDRGGNFTSDYVHNFLRAMQVKHLTTTAFRPQTNGLCERMNGTIVSVLAKLVRVEKRVTDWDIFLDSALLAIRSMPNESTGHTTAKLLYGYDIWTPAIWPSPSRDYVEGEYDAAVLGRVHVIDGIMREFWKEARARDEVRRQRAAARYNRTVIPRTFEVGDLMLLRDHYPRHKLDNKWIDPLAVSRANNNGTYHLVGPFGRRIEEAVNGYHLKPWHKRAAMRPEVQNSAEVRDQLQAFLERRNLSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PH04</accession>
    <name>A0A8H7PH04_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_005237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PH04"/>
    <dbReference type="OrthoDB" id="5598057at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046868">
        <property type="entry name" value="BAR_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046869">
        <property type="entry name" value="SLM1/RGC1-like_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF1">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20400">
        <property type="entry name" value="BAR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20399">
        <property type="entry name" value="PH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="376"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="515"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="613"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="535"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2173817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="694" mass="78060" checksum="436936DAAC250A65" modified="2022-01-19" version="1">METENPNPTNNAPLAIDTNVGHVDAHNQPGSANSQMSSGNVFAESPEAVGTYPPPSQLVGDHSEKTEVEDHTQAPPVFSALAPKLSITRRSTTSYQKQTFRMESGINPAETIAERLEAWRGVLKNLANVFKEMSSANALAAKGYTKSASLIELPFSDGGQHFREEGGIQTVWAATREYALEQSKFHHDYSMFLDQTVIQGLRSVKREAKTMCKSIRNDDRLKTETLYRYREQAEITQHRLNKYINLVNTAPDHANEKADPYIISCELYIDLQKLVHEENRLHDSMLNLQKEFAIFERQLVDNTRNVLRSFQDYRTDGKILSDHTVHMIMDTFDKLEADCEYKVFSVRRQGELVPENAGYKNPADITFENQHHPLVQPIKTGYLERRTFVTKNWSEHRYILTPTGYLHEYKNDKDFPTHPDVSIFIPQTTVTGKNTNMHQGYVFEIRGKNNSAKNKFMKSLERDKTYVLRARNGEDMQVWMDLMTPMSHQFRASVPHEPEDFQQPMNFTNPEVMSRASTWGSTTGGSHAGSDLQDRNLSPVASPTALSPTAEEHGFEDHGVERHGVDNSEHAENNDISRGVSEMSMDEGQAQEVPAGVLTDTNALQKEQEVVPEADKTEILDENNPFVDQDTSSSADMDLGQPGATQEESNQVDESQDTTHGGMHYGTAARIPVTLFDQSEPAEQTQSMPGAFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PH08</accession>
    <name>A0A8H7PH08_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_005103</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PH08"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2173683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="160" mass="18425" checksum="4D6DD6D1AD30B8F3" modified="2022-01-19" version="1">MTGIKFRIALICGRDLAAADKTGFSDPYGVIRINDKKYTTKHINQTLNPEWNFHCDITISPSRAPKAISVTLWDKDTFGRDFMGELMLPFRNVFDRNQGERVGGLPMNFNDPANQAMWFTLNKRSEKDNVKGEVLMKFGFLEDTVRSPTEYAQYFDEITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHH1</accession>
    <name>A0A8H7PHH1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_005190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHH1"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF79">
        <property type="entry name" value="C6 FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="168"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="705"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="705"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="818"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2173770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="972" mass="107257" checksum="3F50A3423D0AAB95" modified="2022-01-19" version="1">MQPDPDPQFAPPPPLGFSSLRLMQTIAKPIMDDVSAEHDKLKSAQGPDLIIKKYESPEADRIKERTKSNKVANACLPCRTRKLKCDGLQPCGRCLHRQTECKFPEGVVPNQRKAVSNDDYNSLEDALVKLEALYTNLFLGEKGTEQARNALMELLQMIPESAFSPGSSASPSCFESTSSKQFVSPPPPNHSINFSFPPPPNQTSPPEPQTSSAVSSVNIDVIQSLSFARGQHFMGETTFYMQPAEAKEHNRSQANLEPPLPNINAQPPAISYQDQIHLIDVYYQHLHTYFPIMSKQLMYSHHYHLFKGQPSYLSPLLLYAIFAAAAPFSENARQFCRDPKELHTAGDQFLQYAIRIREAYVDAPRISTIIALVLLAVRLETSKSGQSTMKAWMLSGEAFRMSQDMGLHRNCESLGISPTDQQLRSRVFWAIFAFDRTLSMTHGRPLAFDEKDIDAPLPDMALEEDADMKETLRLFLQYVKLSKVSGRIIKHNYSPQSGMRASYKQDAMLSTLDSWLASVLMDLPDDLKYVPSNAVVQRDSNSPCVRPPFNQTPLSNDELPKTQFGKLLHLKLHTLLILLHRPYIVDNAGNPNQKPSQSKLIISRPSLDICTYAATIITHICNEMSAKDLSLVAKLSSGLYAMITAIRIHLMNALCNDPKQVGVGEANFERGLRLLRTISNETPGEMVLDTLYSLEQQYRSKGKQLMNTAKPSPRNTASPVTDSTMSTPIDAHQRMDSFSSPRETYRANGSPAKTNDVEETQFQFVPSRRDPATGNPKHTLPLKIIPYGPPGEASSKPSAGGSKERPGVGAPNGVHANGVTNGSSSVSPNTSVVYTPPTTNNGTYAHFNGSMTMTPGSNSIPSSITSTPYDAGESMNYSTMGFFPPLPDSSLAGNNGMMYAPHVTAYPEGDSMDVHMADIMMNDVHHMNMPGVYASRSDSAYLLGDFLHDENMNEESLMSSAPTSQAGKNPHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHK1</accession>
    <name>A0A8H7PHK1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHK1"/>
    <dbReference type="OrthoDB" id="3357341at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2174117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="346" mass="39483" checksum="163D2329FDCFC47C" modified="2022-01-19" version="1">MAVESSAPVHFLLVAADPRNHSIIDVKHKATGEVWYRKLRHIVPNLYALSLIEPETYTVFTEIQSQSSASKEKVISLHDPDALVRIRQNSRLGFEWTFDWKNEKLKWVKESPLSSALECRLLRSDMEICLARYLPRNGGKGSYFGVFSVLENNMNLCNIIDSDGLTLIMMTILFTFFDKADDDRRWKKDKDNYLLDLDFYEIPVERPHNGMDQDKLQKMDLETDKKLMKAMQKGERKTEKQLKRSSAYSSATNSPSISPIPSPTHSTTYIETKQTKRGAPLLRSLSYSSRDGRLKSSNKLNTLLTPFTKLSIGNDTSDGKPVRHHHRTLSAGISDLSTVSSYNSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHQ0</accession>
    <name>A0A8H7PHQ0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHQ0"/>
    <dbReference type="OrthoDB" id="2162691at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRAM" evidence="2">
        <location>
            <begin position="49"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2174239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="238" mass="25979" checksum="66AB1CC43954DA8E" modified="2022-01-19" version="1" fragment="single">TSRLATSGRSSKRRESLDTAVSSEGGFSTAAGSIATACGLEVANTKRNAEFHALFRSVPEDDLLIEGVEERGQFQTLYYGCALQKEILVQGRIYISEHHICFNANIFGWVTNLVLAFSEVVSIEKKMTAMFIPNGILICTLHAKHSFASFLSRDMAYDQMFDVWRVAHPSNPLSSTLKAQVGETTSDNDDDSLVDADDSSYTGSEESDDDDGYPRAEPSQVDALGIARKSSPTESDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJD2</accession>
    <name>A0A8H7PJD2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">chitin deacetylase</fullName>
            <ecNumber evidence="20">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">INT43_005882</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="20"/>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJD2"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000004">
        <property type="entry name" value="Related to Chitin deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF98">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="18" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 22" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034569072" description="chitin deacetylase" evidence="22">
        <location>
            <begin position="18"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="23">
        <location>
            <begin position="146"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAG2174820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="402" mass="43899" checksum="9EF937355D1A7217" modified="2022-01-19" version="1">MLYRIIASAALVATATAAVVTNYTSIVDPTNITIPSIPQTTAYDWQTACVAYEFPVPFDASEWPGDWLVATTNGMNETAEYQALYNSIDWTNVPQIPVRTALAQGELDTTGYDTVNDPDCWWSATGCVTPKVPGVLKDISACAEPDTWGLTYDDGPNCSHNAFYDFLQQQNLKASMFYIGSNVMNWPLGAQRGVRDGHHISVHTWSHPMMTSLNNQDALAELYYATKMIKYVTGLTPLYWRPPLGDVDDRIRWIATQLNLTAIIWNLDTDDWAAGTSVTVQQVQQNYQNFITMGTNGTFANTGNIVLSHELNNMTMGFAENYIPQIKQAYKNVVDVATCMNITNPYVENTVTFPVFASTSSGSNSSSTSGTSGTKSSGAAASSNNANAALIIVALFACFCYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJS1</accession>
    <name>A0A8H7PJS1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_001056</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJS1"/>
    <dbReference type="OrthoDB" id="406544at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF44">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G09754)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="3"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2175409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="170" mass="19568" checksum="3282095C526EAFBB" modified="2022-01-19" version="1">MDLHGSCHCGKTSFDVVSETPAPFMHCYCSICRKCQGGGGYAVNIMGIYETLKLHGEKYMKTYQAIIDKSVPKKDQKLCGNVRYFCGECGSHLFAYSKEWPENVYPYASAIDTPLPEPKPEDIYRLMLNKDSKCNWATTPKIDNKRNFEVYPDCSLEEWHKARNQFIERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJT0</accession>
    <name>A0A8H7PJT0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWR1-complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_005876</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJT0"/>
    <dbReference type="OrthoDB" id="445677at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011421">
        <property type="entry name" value="BCNT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407:SF1">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07572">
        <property type="entry name" value="BCNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51279">
        <property type="entry name" value="BCNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCNT-C" evidence="4">
        <location>
            <begin position="163"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2174814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="243" mass="27188" checksum="3361C377BBCE6305" modified="2022-01-19" version="1">MNKEKWAQQDLESDDDSENDLDYQPDPEDDHESDNDNASVVSEEEDGEGDGKIASKKRKRSPTENNSASDSSAPQLDDSERERKKRIDAIWAEMNSTSTSDKSSKQPLDDISSSMNRSSKTNDEIKDSKVSSSIATPPSSESSSPPEDATAPKRASAPKPTIARPKSNLSALVSQYNIKTPKMNTLDKSKLDWQGYVDREGIREDLKYQNKDGYMEKVAFLQRVDDRRLQDLKAGQRSAPKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKE4</accession>
    <name>A0A8H7PKE4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Spermatogenesis-associated protein 20-like TRX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKE4"/>
    <dbReference type="OrthoDB" id="1923667at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="Ssp411-like_TRX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899:SF1">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spermatogenesis-associated protein 20-like TRX" evidence="1">
        <location>
            <begin position="9"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="726" mass="82541" checksum="C9FCE481C4E46F4F" modified="2022-01-19" version="1">MADAPKYTNRLAGEKSPYLLQHVSFLDANYITQIAHNPVDWYPWGKEAFDKAVSENKLIFLSVGYSTCHWCHVMEHESFENEQVAEIMNKHYVNIKVDREENPGVDKLYMTYVQLTSGRGGWPMSVFLTPDKYPIFGATYFPPEDKMGRPGFKTLLKRIAQMWAASPDTMRENATDTIEQLRSYTEESGTGSAKLDFEKISSSVYEHYESSFDSKEGGFGGAPKFPTPVQFGFLLDYHNYIKDVKTEESKKALSMVKFTLDKIARGGIHDHVGNGFHRYSTDNKWHVPHFEKMLYDQAQLLSTYANIYKITKDKYYEGIIRDIVQYVERDLQHHEGGFYSAEDADSFPHAKASKKLEGAFCVWEKSELNTILGDEDTRIFGHHFDVDEDGNVDPAQDPHGELVGKNVLMEVESVSDTAKALNVSEEEVTHAIERSKEKLWKYRIEKRPKPHKDDKVLTSWNGLMISGLAHAAQALQDPSIHKLAEKAALFIKANMYNEESSTLIRSYREGASNIEGFLDDYSFLIQGLLDLYESEPNDKWISWAAELQKKQDDVFYDKKNHGYYGVPETDDSILIRMKDESDGAEPSGNAVSVKNLLRLGQLLEEESLISRATESVISFHTILTKYPFAMPALVSSYMMHDRGLKQFVISGSRNDSLVQQFQKTINETFVPNKVLVYAEKDGYLASVNQTVESLTKGEQKPLVHICENFTCGLPMDNLEELQDALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PM41</accession>
    <name>A0A8H7PM41_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase II</fullName>
            <ecNumber evidence="3">3.5.4.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_005617</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PM41"/>
    <dbReference type="OrthoDB" id="5569761at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001591">
        <property type="entry name" value="PRK00393.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF29">
        <property type="entry name" value="GTP CYCLOHYDROLASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="9">
        <location>
            <begin position="159"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2176383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="363" mass="41046" checksum="E38AE70C3B22B46F" modified="2022-01-19" version="1">MRPQFTLFGMNVVHDDRSSEQAEDNSPATYSDYINFLKKQVHSPSAVTPALPEPTCIRIQCQVRARIPTNEGGEMYLYLYKNNQDKKEHMAIVYGDDIRSKSLDCAWRDETIVNRIVRGAYYGRLEQIVSDEQSRTLASDDEAMRKLEEQQKVEKEKWKPNNAAPMVRIHSECFTGETVHSARCDCGEQLDEAMRLMQKEGRGVIVYLRQEGRGIGLLEKLKAYNLQDLGHDTVAANVLLNHPADGRTYGIANAILDDLQLKNVRLLTNNPDKIQQIESYGCVKVIERHPMVPRSWSSSPALDGQAHHEAVTPLRVAALLNNLPSPSSSPPPSSTRRLNEMDKYLKVKVEKMGHMLDVPTDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PM96</accession>
    <name>A0A8H7PM96_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_005529</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PM96"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000020">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.4, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF247">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="339"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2176295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="467" mass="51727" checksum="083602C13A0353B8" modified="2022-01-19" version="1">MGKLGKERKRRRLLNATTEKVLVEHEEENRVLEFGGLISADDMATTIRSLNTLKDHPDLIRSKEFKQLRAVMHLANEAAFAVTGKGSTLSGRISDALTDGRWADALVALAEMRSKGQVPKLGALQRWVRDCDAASLRDGSHADPQIFRVLDSILRTADPELIPKPTEPQHPVRQNGSWSAFPRTEPMVNVYDTIQAGNFFTEEQAQQYRSAFRVVHHEKGPERRTPNQYDFTLYHSAPGTIRTTADDVRTPVERIDVPQVPGAFLLKDVLTTSECDQVLSAAEAVGFTPDVPIVGSASESVSILAHNFFWLVDDDFLSTVFKRCEPHFPKEMSGGAIAGLNSRWRVYRYVPGAIYRPHIDGAWPCSGLDPVDGSYKYDMYEGTRWSRLTFLMYLNEEFEGGSTTFFLPAAEVGILEAHGVSPRRGSVLCFPHGNTAGSLLHEGSPVLSGAKYVIRADVLYTCAASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMZ8</accession>
    <name>A0A8H7PMZ8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 13">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="8 13">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">INT43_007627</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="15">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; pentose phosphate pathway; D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 13">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="8 13"/>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMZ8"/>
    <dbReference type="OrthoDB" id="1927044at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000171">
        <property type="entry name" value="Ribulose-phosphate 3-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12 15" id="KW-0170">Cobalt</keyword>
    <keyword evidence="11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="144"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="195"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2176973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="228" mass="24441" checksum="CC4FD5E5EA73F3EC" modified="2022-01-19" version="1">MPEAKIAPSMLSSDFANLAVEATRMTKNGADWLHLDVMDGHFVPNLTMGAPIISCLRKHTEAFFDCHMMVAKPEQWVDDIAKAGGQMYTFHIEATQEPVKLIKQIHDAGMKAGVAIKPKTPADSVIGEIAELADMVLVMTVEPGFGGQRFMADCMPKVELLRSKYPHLDIEVDGGLSLETIDASADAGANVIVAGTGVFKAEDPSQVISTFREKVNTAQAKLAGGASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNR6</accession>
    <name>A0A8H7PNR6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNR6"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2177060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="334" mass="37032" checksum="2E3BEFB74785F09A" modified="2022-01-19" version="1">MSNKLVLLTGGNGFVGAHVCRELLTNGYRVRAVVRSQDKADQVKKSHQEWSQQFEGFSIIPDMTKPGAYDEAVQGVDYVMHVASPFAFPIKDNEKDMLIPAKEGTLNILRAATTQSSVKRVVITSSCAAMFDLSKGIRPGYTYTEKDWNPATWDDAAKSDISIYVYCASKKIAEQAAWQFIKENNVSFDIATMCLPMIYGPILHHINSLNELNESNSQIWNIINGENKEFPPTGVPAFVDVRDAAVGHVSALTVPQASNARYVLSAGSFRFEQAAAIAQKRHPQVHILQGDTSPLDCYTVDGSKSRNDLLRRDYITFEQCVSDTADQLFKIAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNW5</accession>
    <name>A0A8H7PNW5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_007910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNW5"/>
    <dbReference type="OrthoDB" id="9972728at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14868">
        <property type="entry name" value="uS7_Mitochondria_Fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047988">
        <property type="entry name" value="Ribosomal_uS7m_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="67"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2177253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="211" mass="23262" checksum="65FAC4B10B68F987" modified="2022-01-19" version="1">MALWNGLCNVTRQVAQRSVSQHLSRPLISQSCQYSQVATEESSTAAATSTTTLIDESIVTPPEQEFIRQNPIVSQLVNTIMRDGKKARAQRLVSDALQDIRFKTNSDPLVVLTEAIESTSPMLKLTSAKKGSKVVHVPTALRERQRRRKAIVWILEGASKRPEKTFEARLSGEILSVINGASSALTKKNALHKLALANRANAQVSYNTNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPB0</accession>
    <name>A0A8H7PPB0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA replication checkpoint mediator MRC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPB0"/>
    <dbReference type="OrthoDB" id="2130597at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018564">
        <property type="entry name" value="Repl_chkpnt_MRC1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09444">
        <property type="entry name" value="MRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication checkpoint mediator MRC1" evidence="2">
        <location>
            <begin position="568"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="847"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="875"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="916" mass="101280" checksum="6628494567BC14AE" modified="2022-01-19" version="1">MESPKGDDMETSQVADALRASTKVVEDTPDLSLDSDDSDDDRQTSSQMLDGLNINSKIKNLLKYGDIDSSSSEDEEDEVINKPKADEIAAKPKPKLPPKKPRVTTSSVINRMERRANWSNKGSADKQVKEKVTAQKSPLSEDLPANQDHAEPNVSNSSVPSTPIRDASSPQNRKGRSTEFQKILHDMLAEESSSDDDADERLYTRQRRVLEERTPQKQPRKKSEKTPEMPKKAKNVAKSTDSPKPVKVLSEKSKVDLHKESERLYRSADIKLNVSNQPKKTMASFLEKMQAAKKTLPTSDKPKAAIANQGLEEFNLATSAEKAIELSDSDSDLEIIGSANAPITLASAVGTKYSPIRVQVSPQKNRRTPAKDGPANATSAMTHKDLNASLKQAISKEMLKRRSEMENKLKQKGLYTSAEDLAKRQLERENEAKSIYEEVERIHSKSNKAKHLMVEDDDEEEDGDYSDTSQAFGSEKEDWEEEDAVDGSGSEAEVTDNTGKAHSSPQVRKIRRMIIDSDDDSDNEPTGSATRESSPALSIASDESESPVRPSLHTKVSHPVKNRRPMPKSAYVENEAEEEEDEYMGLGGEDGEENDGPDEYVEDDVVVHANEETGNMDEAQLRQAYLDQMADSDQNMIQRLLKDVVSGGLRRRRGAMNDGLELDYYDTFDDMDDDLVALRRMAAAKRRKLLNGNVLEDIANNPQTAAFAKASRVDLEEDEKPSFSDGEEESQPLPQYEEGENDDDDDVDNEEDEDEDGATFADTVQALQQSTITEETHVILEDATEFTEEPQSTETDEDAWASVTITQRQVLKQKFISPSQPNRIRSSPLFRSPSKLQKFKNLLQEAGGAIGGSGDTGSRVGGFSTSGKSQEERSASISSQRSNSTMTSASQDSLPPLSRKGSRLLDILSSQESSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQ02</accession>
    <name>A0A8H7PQ02_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">General alpha-glucoside permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_003320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQ02"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF35">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 45 MEMBER 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="585"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2178067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="612" mass="67892" checksum="39FB2EB7FADD92FE" modified="2022-01-19" version="1">MIQSDDNTPLLRSQNAASGKSRSKPTLIRPAHRRRRSSFDATVYNAGTVPWIQEDIQTREDQKAQDQTGLSLGQILLLTICMAGVQFTCMCFGNLLLLHVGVNYLDPIPSYGTPYLLSLELSKELTALVWLAGPLSGLLVQPLIGAFSDKCTSRFGKRRPYIFVAGILTCLSMLGVAYARDIGDWVVSHGSYEDEQSQKAAVIDHAIYVNKRRQWAIIVCVTSFYFLDFTLNAVQAICRALILDIPPLWQQDTVNAWSARLSNTATVVGHFTGFMDLVHLLPFFGDTQVKVFCIVAIIVFTVTLSVTCLTIKEKPLEVVDESEQPWYHTFAYIWKALRFLPRPIQSLCNTQFFAWMGWFPFLFYRYVACYFYYYNDVPSTEWVSEIYFQSHPSTGTGDDDWAQGTRAGSFAMLCYAIVSVMTGFLLPMLATKAGNEKPSVFSLTNIYTMGHIVAAGALLSSFYVKTVTGATMVLTAMGIPWAIVLWIPFTLVGEFVSFEDERKQNALASNSTKYGTLAGPSSPPNVPKEVDERNEQEEFDAGLILGVHNMYIVFPQFAVAIIAAVIFVLAGASSPEQPGRTGKSGITFVLAFGGCMSMIAAVISRYIVRVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQS6</accession>
    <name>A0A8H7PQS6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_003448</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQS6"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="244"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="200"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2178195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="312" mass="34930" checksum="9520E1E9D41BEA84" modified="2022-01-19" version="1">MTNAISKRSIGDVDTTNKMYQSNSYGPGDPKRYKSTHSIPTDRYSSHYPPLPSIPKTAGSSLQHFRIDESIPQIKNSTATDSRNRLINELPPVNAPDTKSTSAMMLALIDASYPPLLCPSCKHVAANRTEADHHYRSNHHGERNFVCMHPYCQQAYSSKGGLRYHLEHMHSVSLIPESNSTSLPPIINRPPTSPRMKLVASLPSKTRVSESLKKQHPAKRERKRPKPTLLPESEQLLNATYNPLVCPVCRSSFKRKTNVINHLVDSHHGEEPYHCVIVGCTHPKAYATREGLVYHIANYHDREASGNDSGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQU2</accession>
    <name>A0A8H7PQU2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQU2"/>
    <dbReference type="OrthoDB" id="2375302at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2178213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="94" mass="10819" checksum="AF9F4E88B263DD32" modified="2022-01-19" version="1">MQQVMPAQKKVQFSQAIEFIDTFGDDEYDRTCLETTPCTYKDMFELYQLRLELRKETERMLSERDAQDAITEADYASSTSSPATSTSSSYEGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PR15</accession>
    <name>A0A8H7PR15_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003453</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PR15"/>
    <dbReference type="OrthoDB" id="1107506at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00926">
        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003213">
        <property type="entry name" value="Cyt_c_oxidase_su6B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281:SF8">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 12, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000278">
        <property type="entry name" value="Cyt_c_oxidase_6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2178200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="85" mass="9993" checksum="199EC6295F1C6DAA" modified="2022-01-19" version="1">MSDTEEVNTVKLATAGFDARFPNTNQTKHCWQNYVDYYKCINARGEDFAPCKQFYRAYHSLCPNEWVSKWDEQRESGNNPSNFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRD3</accession>
    <name>A0A8H7PRD3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_001723</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRD3"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12339">
        <property type="entry name" value="RRM2_SRSF1_4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF51">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="107"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="169"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2178877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="254" mass="29845" checksum="72866F0B57103E62" modified="2022-01-19" version="1">MAANRIFIGRLSRDAQKRDVEDLFAGAGQIRDVNLKNGFGFVEFEDDQGAEEAVNNYNGKELLGERIVVELAKGTRRENGRDNRGDNNRDRNRREERRPRRNDGPRYGVVVENLASGTSWQDLKDFMRKAGEVSYADVRRDRDSEGVVEFSSYDSMKNAVKELDGSEFKGSRVTIRERRSAPRSNSRSRSRSRSRTPPRRRYRSRSPRDRRRDDDRRRDDRSSNKDKRQRSRSRDEDRRAPRAERESRRDRDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PS41</accession>
    <name>A0A8H7PS41_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PS41"/>
    <dbReference type="OrthoDB" id="2499658at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="2">
        <location>
            <begin position="176"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="451" mass="50083" checksum="C825D4ACC92E6CA5" modified="2022-01-19" version="1" fragment="single">MSQQQASTQSQQMPLNSVLMGYPTRPGNSSQFGHQANYSYNSAAAAYYHVQQQQQQQQQQQQQQQAAQSPSQHHQVAAMSAAAAAMFNDNDQYPTYEDFQCIVQEYLDNLSPKKRDKALVDQHRYTLILQVLKDPRNTAISTAQFRFWVKKMFQLAPTDTLDIVCHDNKPVAMREQIYEILVRAHREAHHGGRDKTSALVRRRYSWIPKELIARFVRNCPFCISRRNSSQSPSIGAPKTPSPTSSYPENNGGVPSYVYDGGQSNHLLRSTFEDDGLSYKHLTPEMDFDYVPTGPQGSNSSVVAAAAAAAAANNCPVVNGPASPSQHYIPDPFGNTNYYYASQQPSTHQGFQRQSSAQQSQPSQQQTSQSDQPGQQGNNNLAYAMVEMGMHPFASADGYSYQQSYGIPYADILGITRVPPQDECFQDLSNGSRPPSTAAVAGVDLLSHHRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTV4</accession>
    <name>A0A8H7PTV4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Amine oxidase</fullName>
            <ecNumber evidence="15">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">INT43_003568</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16153"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:228804"/>
            <dbReference type="EC" id="1.4.3.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="15">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="14">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="14 15">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="15"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTV4"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000014">
        <property type="entry name" value="Peroxisomal primary amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008559">
        <property type="entry name" value="PRK11504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF86">
        <property type="entry name" value="COPPER AMINE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01165">
        <property type="entry name" value="COPPER_AMINE_OXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 15" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="17">
        <location>
            <begin position="11"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="18">
        <location>
            <begin position="108"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="16">
        <location>
            <begin position="238"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="13">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="14">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG2179785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="676" mass="76862" checksum="1BFE69FF8E8ADEF9" modified="2022-01-19" version="1">MLNCKSYHNPHPLDSLSTDEVSRTASLVRNSQKEREKFTFSTITLHEPPKDIMMAYFGWSKTAIKPEAIEREALVVIMELHSGNVYEIIVSLTRNKLKSCIHVDGVQPIVTLEEADEVEKLMQNDPRIAAECAELGITDMSKICCDSWAIGKHMDGAKKRIMQGLMYYRLHEHDNRYAHPLDFVPIVDVNKMEIIEIERIPTRNSKFRRPTIPMTPHNYYPEFVGEENLRKDIKPLIIQQPEGVSFKVNGNEIDWQKWNLRISFNYREGLVLHNLNYQDRDERRPLFYRVSLSEMVVPYAEPSSPHFRKHAFDVGEYGLGWSSNSLSLGCDCLGTIHYFDATLSDAFGNPFVIPNAVCLHEEDHGILFKHSEFDSGRAHTVRGRRLVISHIVTIANYDYACYWHLYQDGTINYEIKATGIVNTHVLAEDETPGPFGTMVAPQINAQHHQHFFTMRIDPMVDGLNNSIAQVDVQAVKEPVGHPKNKFGNGFYPKTTVFKDNVDGQASANFDTARFWKIINPNKLNPRTQEPVSYKVVSHSTSPLFAKPGSIVHNRAGFASKTIWVTPYEKDQMFAGGFYCNQANGEDSLPSWTREKKPIENTDIVMWYTFGITHLVRVEDFPVMPVESCGFSMKPCNFFSCNPALDVPSTTKAINQSVPAFKSVCQGDCKDKTTHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUE3</accession>
    <name>A0A8H7PUE3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Urease accessory protein UreF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUE3"/>
    <dbReference type="OrthoDB" id="2550922at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="entry name" value="Urease accessory protein UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01385">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009467">
        <property type="entry name" value="Ureas_acces_UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2180043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="26506" checksum="57D8D9AFA6A9E87F" modified="2022-01-19" version="1">MTIEGNHFLVDDSSNWLLYLLTDSALPTGGFVSSSGLEAAYQAGLITSATGLPDFTVSAAHSYACNTVAFVRAGFLALDDEDPLARLEDADSFCEALMVGNTVARRASLAQGVAMLTLHIKCFSPHDELVKEWKKKIRAGKVDGHFAVCFGLVCKNLNVSLENTIHLWLYLFTRTLYSSAVRLNIIGPYEAQRMLLQSKGGIENIVNKTKSMTMEDACQTNPLLDICQGMHDRLYTRLFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVI3</accession>
    <name>A0A8H7PVI3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_008947</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVI3"/>
    <dbReference type="OrthoDB" id="9975416at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2181364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="199" mass="22385" checksum="25E95AD143E3FD47" modified="2022-01-19" version="1">MARHTADTGYTSAQKFHNSDIREERGDRITLRAGTIGDALAIAEIGGSVFSATFGHSLTETDLNHYLQKSYSVEAITADMNNPLMDFVVAYNEHDRVVGFAQMTQGTSEPCVADAELPVELQRIYLHQDFHGLGIGKRLIQEIENIARSKGFITMWLGVWEENFKAQKVYQKAGYTKVGDHDFKMGYCIQTDWIMSKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVP3</accession>
    <name>A0A8H7PVP3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_008521</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVP3"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2180941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="257" mass="26553" checksum="B77B8581D47C4531" modified="2022-01-19" version="1">MAEPIAANNNLEKEEIGYNNQAPGAGYNQGAAGAGYNHGAAGAGQLAPSAAAPAQRVIANPGPLGLSAFALTTFVLSLINAGAGLDPNGPSQVVVGLAIFYGGLVQLLAGMWEFATGNTFGATAFASYGGFWMSFGAIFIPGFGILEGYMGADGKLDAGVLDQSLGIYLLGWTIFTAILLIASHRSNMGLVSLFFFLFITFVLLSAGKFNASTTCTRAGGVFGIITALIAWYNALCGLLTRESSYFVLPNPSLNRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PW48</accession>
    <name>A0A8H7PW48_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Lysosomal dipeptide transporter MFSD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Major facilitator superfamily domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">INT43_008535</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79415"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:79367"/>
            <dbReference type="ChEBI" id="CHEBI:229968"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:79375"/>
            <dbReference type="ChEBI" id="CHEBI:229967"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79383"/>
            <dbReference type="ChEBI" id="CHEBI:229966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79371"/>
            <dbReference type="ChEBI" id="CHEBI:84315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-arginyl-glycine(out) = L-arginyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79391"/>
            <dbReference type="ChEBI" id="CHEBI:229955"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79411"/>
            <dbReference type="ChEBI" id="CHEBI:229953"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79379"/>
            <dbReference type="ChEBI" id="CHEBI:229964"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-histidyl-glycine(out) = L-histidyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79395"/>
            <dbReference type="ChEBI" id="CHEBI:229957"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)</text>
            <dbReference type="Rhea" id="RHEA:79399"/>
            <dbReference type="ChEBI" id="CHEBI:229954"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79387"/>
            <dbReference type="ChEBI" id="CHEBI:229965"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79403"/>
            <dbReference type="ChEBI" id="CHEBI:229956"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-lysyl-glycine(out) = L-lysyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79407"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="24">Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PW48"/>
    <dbReference type="OrthoDB" id="424834at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="26">
        <location>
            <begin position="1"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00044985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00045018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00046376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KAG2180955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="448" mass="48398" checksum="9ECDF66ABE7E5549" modified="2022-01-19" version="1">MDSIPSETTPLVAKVQNRRGTKVDTTGECYSDTTSDQNAINLQLNERLGSSYEQWQYQLNILFAVATIPNTVVPIFSGVLVDHFSLRTLFTLFTILVIVGQAIFSLGVTYSHFPIMVFGRLVMGIGFGAEDLVQCKITTDWFKNNFLAFALAMNLTFGRLGTAANFTITPMLLDKFGLTEAQACWFGLCITVVSGLAVLVANYLDRPESRVAAGVPIYNSCPADNNESYEDGKISCTDFSRLGSLFFALLLGIMTIYGACQPFLHIASDLLQTKYFPNDPIRAGVLQSVPDILSALLCPIFGLLVDRIGKRSRIIGTAALFLCISHLMIAFTDITPVIPLAIFGISYAAGTTAVWPCVSLVVPADRLGTAIGIGEASLNTSLSLVPLLVAVLSTKGSFLKVELLFAGLSALAVLCSIYMYIKGRQTGGAMEKTIFDEVEEDEESASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWT8</accession>
    <name>A0A8H7PWT8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chromatin associated protein KTI12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_008856</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the KTI12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWT8"/>
    <dbReference type="OrthoDB" id="9972657at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12435">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2181273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26971" checksum="D9AD336841077B5C" modified="2022-01-19" version="1">MLGISKSAYREAKDEKKARGSLMSAVERLVSKDDLVIADGMNYIKGFRYQLYCIARAISTPHCVVHCGTPINLARQWNSEKGDSAYPEDVFEELVTRYEEPDGRNRWDSPLFTVIYDDPSVPQDKLWDAIILKKAPPPNLSTITKPVSETNFLYELDKATLDIINSVLETQKNQGEGGLPMTVPRSSKKVINPTRTITMSELRRHRRQFTSINKLHTSTNIDTVADMFVDYLNTNLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PX64</accession>
    <name>A0A8H7PX64_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_006833</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PX64"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PAPs-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="ACID PHOSPHATASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953:SF153">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="223"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2181908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="535" mass="63020" checksum="00BF7562773811EF" modified="2022-01-19" version="1">MNFFEPYSSVSFHHKVATSPHPSTAHDRFGHDFTLIKGKRHYPASRYCGSHFFSRRRLRLKLMVATVIFLFFFLFMFDFMQLYISIFRFKLRNSLYDKGWVRCNSIRKEPAIFVIDTRHVQVVWEVNCGFEDQDLLVSWRVTDDPLDPEYHEYGITKAIAPHALDEHHKVYKAILGPLPVSANYTYSILSSPRQPPSRRRKLAEFTFPWHAKAHTMPTVQEPIRLAAIADNQFGLKTFQKVARNIAHRGQFDYLIHAGDAVQNYPSLQQWQTDFYDPLNNYQLSQKTPIIYAHGNHDEDLTLEYHYTRHDNHQHWPWFSFTFASNSVKVIVLDSNLDWHEQDAWLEHELRSDESRLAKFRIVIVHIPPFMEFWDPVPWSQGESEWGRFVRDRFVPMFERYGVDLVISGHQHNYERGERNGVMYGIIGGAGGDLDFDRVNNWNMYEKTRFHFHFVALEIGQLEDETWQLKWDMFDINGQAIDQAFIRSRPPLPVWAVDEQPNENSESSSLEDALDPDWEDSTPADWQDLELAAENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PY54</accession>
    <name>A0A8H7PY54_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_007203</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PY54"/>
    <dbReference type="OrthoDB" id="2150324at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF149">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="622"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="659"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="686"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="26"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="215"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="10">
        <location>
            <begin position="396"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="916"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2182276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="936" mass="106316" checksum="80AB8CCC13517644" modified="2022-01-19" version="1">MSAAPGIPFQLVENNNTNGRMDLTGLATQLGINAAIAVVVILAFNVLRPNHTMVYAPKVKYAPDGKRPPKVGRGFFDWVKPVAKVTDDILIQTIGWDAVLFIRCLRMFRRMFYGLTLVGVFVLIPINIAATSQTGDQWPPTTSNILNVLSIAGINTYGNSYDKTGEMAWFWAHSAGTYFISAIVYFCLWRAYSEYVNMRQQYFESQDYQSSVQGKTLMIMNVPTGLQSDEKLRKWMQSMTNKYPIQQASIGRRSGMLNELMMKHEATVRQLENVLATYLKNGKVSDKRPTMRVGGTMGCGGRQVDAIDYLSQQIQGYEEQIEHIRTNIQGIKSENYGWVSFSRVGWAHATAKQLKNGVPSKFKTGKLSSPVIRLAPQPNDVIWRNMALTLAARRSKKFFWNIVYYIFLVIWFVPTCLLSASSNIKNLVDIIPNSETFSKNNPFLISLFESWFAPLVMALFFLILPSFLRAISRRQGYITKTSLDRQVLGKLYLFFIINNLLVFTIASTFVGLYKQIQSTVSNGDTINIISLFRSNFNLMAKSFANVSTYWTNYVTLRSLGILLDLAQIVSLLYVGFRKVFTNPSPRSLKEFTRPPYFDFALSYNLLLFFFTVGLVYSVIAPLILPFALFYFFIATVVFRYLLMYIFTTKTETGGQIFRVVVNRMFVSIVLFQLVMILILYFKSAKLQTYVICPLPIITIIVKIVVSRRFDPLAYYSNNRFDQEHAIPSVDGPGATISRRNRIGIRFGNPAFFAELPTPMVHENVQHLLPQVFSGKVRGIEENFTSKVTRKKTVKHMSVINRGDQHDLRFHAVPANELDIDDGAEGLDGVYRYNENDMTPYPMSTPMMAHNTPVMGYSQPHGFQAFRRPSDFDDPYAANRPLMAQEYDHPTPSSAEMDSGYFGNESHQNETYEMGAMHHEPSYYPPPSAGRYGPPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYA5</accession>
    <name>A0A8H7PYA5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYA5"/>
    <dbReference type="OrthoDB" id="2374895at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2182140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="229" mass="26638" checksum="B40F1821BF52D0B9" modified="2022-01-19" version="1">MMMEEPTSNIAFNLKLQRSQTFQLRFDDNGHYNFSNIPHADFASPKILTPDFEYNDTRGYLNTEDSFSDATSDSTDVEQPSPEVNFSTSGLSPPPSMARKPSAETIPKSRTLSDRHAQCRLSFGLPSNTEIDDYNVNDDESYLAKSSMEQDRNEYTDLLQTAYEEQQEEITYCRDRIEQSKYAQDMMQTIHHRDEEINKMQTAMNRFRRLLKLKDNEIRDLLKIIQESC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZ26</accession>
    <name>A0A8H7PZ26_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rhizopuspepsin</fullName>
            <ecNumber evidence="3">3.4.23.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_007446</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1'. Clots milk and activates trypsinogen. Does not cleave 4-Gln-|-His-5, but does cleave 10-His-|-Leu-11 and 12-Val-|-Glu-13 in B chain of insulin.</text>
            <dbReference type="EC" id="3.4.23.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.21" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZ26"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000115">
        <property type="entry name" value="Lysosomal aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034804236" description="rhizopuspepsin" evidence="11">
        <location>
            <begin position="20"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="12">
        <location>
            <begin position="77"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="313"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2182515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="412" mass="44975" checksum="E866152C2271D3EA" modified="2022-01-19" version="1">MHFTLKLFSIAACAQLVLGNLVIPLEQKRSGNVLNTPARLVRTLAKYNPNIRVADDTKRMQAASSIPLKDNLLDVEYVGKIGVGTPPQDFYTVFDTGSSDIWLPTKQCAACEGHHIFQEMDSSSFRDIGKNWSLSYADGSYISGRTASDTVNIGDITYKDQIIGLASDESGQFAADHTLDGIFGLAFPSLSLTGVKTSPVVMMHEQGQIDNPVVGVWLGRAREGGGGEMTFGGTNQAHYDGQFQYVPVDNQKYWQVKLTGVSSGGQKLSLQSKEAIIDTGTTIIVAPADIVRHIHAGIKGAVFTLKSGWRIPCSANSTNQKVDFELDGKTFAIPVSDLVREESTEKALCYSGLIESDLPFTVMGDVFLKSCILSRQQFINKTLDVKSWFCLTLVSDLPLADFNVEDHEYVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZ66</accession>
    <name>A0A8H7PZ66_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007388</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZ66"/>
    <dbReference type="OrthoDB" id="5595797at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021386">
        <property type="entry name" value="SPP41_DUF3020"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11223">
        <property type="entry name" value="DUF3020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2182458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="292" mass="32675" checksum="191B9192A3F968D6" modified="2022-01-19" version="1" fragment="single">MFSCSQCPKVFATRSNLKRHLENPNIHNIPYVRSRDQKRWKGHAKKIVSKQETTERSVPIKSMRKWRAENRDKNKRNDLRCRVYRLARQRFGDNDCSAKQAFIREEIAKRLGRRMIFLGDQAPPESPVPSLMPRRSSSTSESSFSSEDSYGDEFNPVYNSYSQAAPATCHKKPIALPSISQCLMQSDDKFAMSLPLPKPSFSACSTPSLSPTTPTAGALPTLHGMESSAAWEYRGQCTAALTTPNQPHASPKPLPGLMTASKNKSSKQADNFNILEDFVSTVLDYAGVRDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZR0</accession>
    <name>A0A8H7PZR0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arb2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZR0"/>
    <dbReference type="OrthoDB" id="421951at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048263">
        <property type="entry name" value="Arb2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053858">
        <property type="entry name" value="Arb2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357:SF4">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22749">
        <property type="entry name" value="Arb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arb2" evidence="1">
        <location>
            <begin position="26"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="293" mass="33156" checksum="867CEA1E0692D0A7" modified="2022-01-19" version="1">MQFIRNVFSSFFSLDNYGDTEHDYHFPTTMEGFGYQFNENGQLTQTSTDEPFQYKVKENDRQYNQAHYEALGVCIGHHIEEVLMTEYNLQRLQIPLKEPNDPEDKARSHVYISEDALTSPDTLLVLLQGSGTIRPGQWSRRVIMNESLEAGSMFPYIERAQHNGWNVMILNPNNNEIAYEDGDGQDFGGEGGLSFSKNPGSMTIDGCETPEHHCQYVWDNLIKDCKAEHIVIVAFSYGGHAISVLATQNALEFTQRVNALALIDSVHSHTEHENAPGAAKDSIMQYLENEINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0Q5</accession>
    <name>A0A8H7Q0Q5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 1, mitochondrial</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD1</name>
        <name evidence="14" type="ORF">INT43_006779</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 alpha chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
        <text evidence="12">Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 beta chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0Q5"/>
    <dbReference type="OrthoDB" id="4330at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03208">
        <property type="entry name" value="PS_decarb_PSD_B_type1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033661">
        <property type="entry name" value="PSD_type1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5035025168" description="Phosphatidylserine decarboxylase 1 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035025170" description="Phosphatidylserine decarboxylase 1 alpha chain" evidence="12">
        <location>
            <begin position="403"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="12">
        <location>
            <begin position="38"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="402"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2183768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="438" mass="48882" checksum="B228F82ED64D1258" modified="2022-01-19" version="1">MRAATERVFDAWKNTKMNWAPIPVGLGLGLLCVIQYRRVVRREKERQSGVKVPDRKYVASGPWQVHVAAALPLRHMSRLWGAFNSINIPEFLRPAGFRLYSWIFGCNLDEMKVKDLKAYPNLSAFFYRELEEGARPIANAPLVSPSDGKVLHFGVVEERNIEQIKGVTYSLDALLGMENSSAGQPEDISFDPNTSNVDEDEFANVNGISYSLDDMLGSEKTAHAVKAPSSVGPDGLAREEKDARSDAKNEELVRLVDVEPKGDLSHKTKPGNSLYFCVVYLAPGDYHRFHSPADWVVQMRRHFAGELFSVSPYFVKLLENLFVLNERVVLMGKWKHGFFSMIPVGATNVGSIKINFDEALRTNRKEDLATGTYTEVSYKSASKKLGGKPLQRGEEVGGFYLGSTVVLVFEAPSNFKFKLEQGQKIKMGEAIGGYDEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q188</accession>
    <name>A0A8H7Q188_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q188"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2183199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="78" mass="8733" checksum="697987AF1DEC813A" modified="2022-01-19" version="1">MEDILTMSFLSMITMRVIMSKKTIMIIIMSTNMAITIMAMMITVTAVLSPESLSQFLLTAKPTLFLAKLELWIPTAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q214</accession>
    <name>A0A8H7Q214_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_000892</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q214"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658:SF18">
        <property type="entry name" value="PROTEIN GAT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="6">
        <location>
            <begin position="467"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="337"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="397"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="513"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="650"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="437"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="548"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="650"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="692"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2184979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="748" mass="82335" checksum="677F20F1F7FF2EB1" modified="2022-01-19" version="1">MDSKQRSRANSELLMSSRLTNGHQSWIAEAFQKYHVQNPTSSEIAHLRHIESRYLGTATLQLGAQRLPHAAFYEITESEISEQGFERKHARSSSSHDSLPTMATFHQEQSLPHEDHENSPDSQSKLLSTECCSASETSCGRPDCAYLSLSESIAATTLLEKYAADDDANFNNMSSVALPPKKRKRRRIVRQDIAFTFVSHQGDEQYLPPDAHYYCFPKDALAEPLSEEPPYEIIVSFQLCKTMLSENFLDSVCPSPLCNGRQFLPDSGYQNLSFSRSSQRRFTDPGQKPVAELAFQTMQVVNLRVSNAPTHIYNAIKKSVSRFEVLCRRMVELSKQHGERVAHRRAEELSISRSVSTSKSLPQAADDEDDEMEDKHHGYESTDTICKIDNWSSDENGWDKESHADGSARAVSVSANSDTHMDMTISGNKSSGSEAVASPKLSASLPSKLPSNGLNQNKQTKQQALASGNMKKCLYCGSKSTPMWRRGPQGAGTLCNACGVKWKHGKILCGSNTESHATSNGDHNGKERKGSKADKKRKKAEASAAAKKEKRPKVKNRKGKKVKTAMDSVEEDPNAFTLGMELDEDEDSNVDPVGDSTPKGDAYLYDDEEDDDDSSTLAGQDHMDIQTAVKAEPVFAIPFARTNTLERLASSQISHGHPSQQQNLLPPGRSTWDTVYSSSSSSSISTFEPFSPRESYASSPTSSPSSLLLDISQSDKRTMNNAIVEGFAQSAVDDAVEAATVLTMLRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q281</accession>
    <name>A0A8H7Q281_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_000487</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate</text>
            <dbReference type="Rhea" id="RHEA:22936"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="3.5.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q281"/>
    <dbReference type="OrthoDB" id="10264777at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000065">
        <property type="entry name" value="N-acetylglucosamine-6-phosphate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="12">
        <location>
            <begin position="64"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="244"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="358"/>
            <end position="360"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2184578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="436" mass="47436" checksum="927548BA0FC33C8E" modified="2022-01-19" version="1">MAVRPQTDTEGKIVKIINARVLLNHKLTENSYLWFKDSKIIDPQELFFQDHKEPDMVIDAENAIVAPGYLDIQINGAFGIDFADENLPVEDIARNKDVVAKGLLQFGCTSFCPTLVSSAPQVYHKVLPHLRKRLGSVENGAEILGVHIEGPFLNPEKKGAHNEEVLQCAERGMESFDDTYGPALKRDDSIAILTVAPEVKGVLECIPTLAKRGICISMGHSTASVTEAELGVRAGATCITHLFNAMPAFHHRDAGICGLLGSTTLPIPKSQKQHPIPSQSSPSPTNPDPRPFYGLICDGIHVHPNSVRIAYHSHPKGLVLVTDALSSMGLPPGCYHLGDYEVEVNAQNVAYVKGTKTLAGSNITIDRCVQNFRKFTKCSTVEAIEAATLHPAQVLGIEKTKGTLNAGSDADILFLNDDLEIQRVFVRGEEVDLKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2T2</accession>
    <name>A0A8H7Q2T2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphoadenosine phosphosulphate reductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_000404</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="7">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2T2"/>
    <dbReference type="OrthoDB" id="7869097at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23945">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000136">
        <property type="entry name" value="Probable phosphoadenosine phosphosulfate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011800">
        <property type="entry name" value="PAPS_reductase_CysH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02057">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002537">
        <property type="entry name" value="PRK02090.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509:SF1">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="9">
        <location>
            <begin position="46"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2184495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="289" mass="32712" checksum="7461B5B8EF973048" modified="2022-01-19" version="1">MPVSTQYTIRSGDDLTPERLETLNAQLAKFSPKEVLEWAIDNLPNLYQTTAFGLTGLVTLDIINKISIERQQDHIVPLIFLDTLYHFQETLDLADRCVKTYSVPLKVFKPVDCSNAAEFEAQHGQKLWETNEDAYDYLVKVEPARRAYDELNVASVITGRRRSQKGDRAAIPVIEVDGTGLIKLNPLAYWDLQQVRTYVRANEVPYNALVDQGYNSIGDWHSTNKPASKDDERSGRWEGKDKTECGLHKDYFKMRAAFMAAKKAKQQLEEQKKQQQASPNVSAAVEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2X5</accession>
    <name>A0A8H7Q2X5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_000464</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2X5"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000001">
        <property type="entry name" value="Aldehyde dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2184555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="496" mass="53720" checksum="AD08EDC79105EA12" modified="2022-01-19" version="1">MTQSDIQTIVTQSGKELKVHTQLFINNEFVPGNGPLIEDINPSTEEVICKVHSATEEDVNTAVEAAHTAYKKVWSKVAPAERGVLLNKLADLMERDQEELAMLEAIDNGKAVSVARDEDIAGCIGCYRYFAGWADKIHGKVIDTAPEQHIYTRHEALGVVGAIIPWNYPLMMGAWKFAPALAAGNAVVMKTSELTPLSAYKFATLIKEAGFPPGVVNIITGYGHITGSALAAHPRVSKMAFTGSTGTGRKVMEASSTSNLKKLQLELGGKSAQLVFADADLKHAAQQAAAGIYNNHGQNCNAGSRIFVHESVAKEFIDLFTEQAKAVKVGCPFKEDTFQGPQVSKAQFDKIMEYIKIGQDEGATLHFGGKRVGDKGYFIQPTVFTNCNNNMRLMREEIFGPVVAIGTFSGGWEEAVELANDSDYGLAAGVYTSDHSTAIKASNALLAGSVWVNCYDLFNNSVPFGGYKQSGFGKELGKYALLEYLQVKSVITLIDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3T1</accession>
    <name>A0A8H7Q3T1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endoglycoceramidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_000696</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3T1"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901136">
        <property type="term" value="P:carbohydrate derivative catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF3">
        <property type="entry name" value="ENDOGLYCOCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034835564" description="Endoglycoceramidase" evidence="5">
        <location>
            <begin position="26"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="90"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="7">
        <location>
            <begin position="411"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2184783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="55431" checksum="B47F0466873789DD" modified="2022-01-19" version="1">MQLVTCSLITSAISVLLASSTLVSAVDPQGWYAANPGLSKIGLVNQNTHQITDVFGRVRFFHGTNVVMKQAPWYRSSNFDPPNSFGLQDVQNLQKLGVNAVRLGHHWAGAEPVRGQYNQTFLDIMKSQTQLAEDHGIYILVDVHQDVLAGQFCGHGVPNWFAQHSWVSSYKAFPVPQKLTPFAVDSNGMPTPSSVCDSIDWSLSYLTVAVCNAFGRLYNNYDNLGDSFAAYWKKLAQQYTNTTNILGYNLLNEPWVGDSYSDPTLLTPGVADHKNLEPLWNKAATQIRTVDTNKLIFFEGTTYDILSGFNNVPLGDGSRTVQSFHYYNPPQLGTIQTTIKNRIQDNVRLHTASMLTEHTMWMGDATQMANIQSAVETADTYMMSWMGWAYENLYNTTTDQPYSEIAAFYSRAYPAAVAGNPTSFFFNSTDNSFNLAYTISKNVSAPTEIILPVGTYPNGYTVSTTPASSLVQYTKDSMTLALFTADNATDGQAVTVHITKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4E9</accession>
    <name>A0A8H7Q4E9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peroxisomal membrane protein PEX13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Peroxin-13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">INT43_000395</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Interacts (via SH3 domain) with PEX14 (via SH3-binding motif); forming the PEX13-PEX14 docking complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxin-13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4E9"/>
    <dbReference type="OrthoDB" id="10037838at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11771">
        <property type="entry name" value="SH3_Pex13p_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000128">
        <property type="entry name" value="Peroxisomal membrane protein (Pex13)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007223">
        <property type="entry name" value="Peroxin-13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035463">
        <property type="entry name" value="Pex13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04088">
        <property type="entry name" value="Peroxin-13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="341"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="409"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2184486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="441" mass="46848" checksum="84569E94BD37F762" modified="2022-01-19" version="1">MPSPPKPWEAANGNTGSAAVASAAITSPSVAANMSTGGLDSSFGSSPDIPVRPQSLATTRPTGLGTGAYGSNYGSSLGSGYGTGYGSSLSSPYSRYGGMNSYGSSYGSSYGGYGSYGGMSSYGSPYSRLGSYGGMGSYGGGMSSYGGYSPYNRMGYNGMGGPGGPEDFSLTQRMETGTRATFEVIESIVGAFGGFAQMLESTFMATHSSFMAMVGVAEQFGHLRTYLGQVLSIFALIRWAKSIFYRATGRQPPANPQDLNASDFQKFQEAAPTKLSRKPFLIFLFAVVGLPYLMHKLIKHITAKQQQQQQQQMFLPDGTPMQPQQMNGNIPMQQQEQVDPQNLEFARALYDFNPESPMELNIKKGDIIAILSKVDQATGTQSQWWRGRLRNGTMGLFPANYVEIIQKAAPNNGPGASAPATPNLLDNPAPTVPNTPNPTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4T9</accession>
    <name>A0A8H7Q4T9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UV-endonuclease UvdE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002268</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4T9"/>
    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004601">
        <property type="entry name" value="UvdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00629">
        <property type="entry name" value="uvde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290:SF5">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03851">
        <property type="entry name" value="UvdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0228">DNA excision</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="414"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2185831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="53531" checksum="5963650E82D5B273" modified="2022-01-19" version="1">MGTAIVQQTSQFRGRLGYACLNTVLRTQKPPVFCSRTCRLDTIRTKGLDYAKELALQNINDLKALIEWNELNHIKFMRMSSEIFPLASHDKVGYSLDFAKNELAEIGKLREKYNHRLTFHPGQYNQLASPNKDVVRRTIADLQYHVSMLELMELPPDSIMIIHMGGTYGDKESALDRFRENYKTLPQNIKDRLVLENDEICYSVADLLPICQELSIPLVLDWHHHRYSRLSRIVEHCFKHGYITIASYNSINTGDIEDITQLLPQINETWTRKGLTPKQHYSESRKGAVTPMERRAHSDRCILPPCEPNTDLMIEAKDKEQAVLYLYRLYNLYPVNEDVFYENENVETKHTLKSKKGLKAVKEAKLQAKAELEAKEELESFSHDEKPNSKKKRVKLQKIAVEEITDNGTEEVKALKKHKPVKHQIKEEVEADDTEALQVSSNEPEVDTGLRRSKRTSSRKALTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q590</accession>
    <name>A0A8H7Q590_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002222</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q590"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="18"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="211"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="321"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="249"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2185785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="374" mass="40454" checksum="3BD7839466EF9171" modified="2022-01-19" version="1">MSTRHARTADKAVNERNTKTLKALLQQPDNKYCADCKKKDPRWASWNIGVFVCIRCSGVHRSMGTHISKVKSVDLDTWLPDQVENMVKWGNARASKYWEANLKDRQPSESNINGWIRAKYEHKRWAMPGPIPDPSTLGGGADVVPAANPTVQKPVESPPASKAKQSEFANLDAFLGSPSSPVTKQVSNHSSPPQQLQGADFFATTNNDIRHASSAPVTPAHSRPETPANSMKSEDASGSTNKHKDIKSSILSLYNTPRSSGNSGNLAGQPSQATNSYASNMGNFQQQLSGLSIGPSSGMIPQPPTQQANLYQNVWGGFQEAPGQSAWTDDFSSFSKAEAQPAPSNGMPQGGQFFSMTSQPSANTQKPAQKPNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q608</accession>
    <name>A0A8H7Q608_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q608"/>
    <dbReference type="OrthoDB" id="2438895at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034288725" description="Transmembrane protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2185955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="12865" checksum="97C84B114413DA04" modified="2022-01-19" version="1">MSKFLTLVFVLVAVIIAAASAAVTPDYALFTPGHPHLQARQASAVVASPSASAPASASSAASSSKTAPAPAKKKKSNFVSSPILESGTLFYVGIAASLCLWTTGKSIDYALQRQERYARHLATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6F6</accession>
    <name>A0A8H7Q6F6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal recognition particle, SRP19 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_002571</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6F6"/>
    <dbReference type="OrthoDB" id="2190947at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006617">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="entry name" value="Signal recognition particle, SRP19-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2186133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="28462" checksum="886E0FE4840C0351" modified="2022-01-19" version="1">MLNNLKKTKPNAVFLDNEDEDDFDVDNMDFPLPTDSSSSGGATGLEDMMAKLAAGQTQRPDTGSGKAGEIAVVNTPQGVQRLDPSVYKRWVCVYPCYIDAEKSLDQGRKIPKAKSVNKPHAYHMALAVQKLGNMSVVYEGKKHPADWANPGRVRVQLKNGQFFCNPKYTSRKQLILAIADALPEIQKQNEIPKHIVSPLTSLREIEELANEQRKAQGLPPIESSAPPPTNAGAIESAESSTKPKKVKKQKMKKMVVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U6S0</accession>
    <name>A0A8H7U6S0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_008121</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U6S0"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="130"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2171741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="221" mass="24879" checksum="51C1020942999EC4" modified="2022-01-19" version="1">MKGSYPAMAPAPTENRTWSKEQRSHVPMPYTMNQVMPQPPNHYQAGTFAQLPPHIAAIDLPMQARPNLAPAVNPPYMHHPIQPPSYVRRQYTHGRSLSDYSHNVRPEASHEFVQSHRRAISATTSEMVGHAMETEEEVDSERSGSASPPSQFLESPAGSGSGRFKCPYCQKSFSRPSSLRIHTYSHTGEKPFQCLHPGCDRKFSVQSNMRRHLRVHRLGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U6U6</accession>
    <name>A0A8H7U6U6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U6U6"/>
    <dbReference type="OrthoDB" id="10420482at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="218" mass="24919" checksum="B882D6A7A3BB406F" modified="2022-01-19" version="1">MVILAGAYSQLLHGIWKPTNALAIKFGRLDIHDDIARRASFVWQYYWWWRVGVFVLCAILFFGTIIALRVKKDWLTNVASQQKIQTTCQEATQTQNLMSSHQEKESSQPPCSAIHRKVALRCVLYVLVLLITRVFGVVLITETLDLNDEGDQYLITTFALGGIQGLIYFSDPAVVATAKDLKSYWKKRRSDRHDDQEIHDVDAFISQDRCIPSEISQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7J2</accession>
    <name>A0A8H7U7J2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trichome birefringence-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_004252</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PC-esterase family. TBL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7J2"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016413">
        <property type="term" value="F:O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029962">
        <property type="entry name" value="TBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026057">
        <property type="entry name" value="TBL_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285:SF48">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13839">
        <property type="entry name" value="PC-Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Trichome birefringence-like C-terminal" evidence="4">
        <location>
            <begin position="356"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2174231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="444" mass="50689" checksum="8BABA855E67CE10B" modified="2022-01-19" version="1">MDQRQVRTSRRSAIRFVLYALIILFVYRLIASFASDDKAAPSEDVPTPKDPAPHLGDNVKGAQEQKPKAPPITNEKPEVDLPWYPKVSKLTTAERIELEQQAISKARAIAQDAMSHYNIQGIPGSAIKTAQEAKEFYQKAQCFTQGSWVYAPHERPLLKHLQEALYSKCDKRYAKGEMLTDKSDWKVRPDLKYIWSPLDKTQCPLRPIDKSKWCKMLHGRHILLVGDIVQFQMHELILDTFRDGPVVCYGELNCKDHTLCSGPETRLRYLRNDLLSVVRKNPETTEGKPHMRVVQWPWITSNIVDKFPVLILNRGGSYVPDDEFRDQLIETMKNIRNVKLDHLIIYRSTPIGHPDCDSATGPLASRPTESELQDLPYRWGDFKRQNMIAKEIVEAAGGVFVDIAQMADLRPDGHIGGHDCMRYCIPGPADAWVDVLYNMFLLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7V1</accession>
    <name>A0A8H7U7V1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_004746</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="10"/>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7V1"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000016">
        <property type="entry name" value="Putative choline-phosphate cytidylyltransferase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="83"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="298"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2172205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="332" mass="37894" checksum="7D9A9885EEBD6C1A" modified="2022-01-19" version="1">MSSIRRKRSARSTASAVSSSRDQAFSRDASDEDNNELANEPVPPRLTKRTKTDDDLDHALPAPQEAYDFKINPPPKGRSVRIYCDGIYDLFHFGHAKALEQAKKAFDDVYLLVGVCSDAETHRRKGKTVMKDLERYEAVRHCKWVDEVVKDAPWTVTQEFLDEHRIDYVAHDAEPYQSKESGDVYAFVKAQGRFLPTKRTEGISTSDLITRIVRDYDSYLRRNLERGVSAKDLNISFFKEQEIKTKKSLQQLRATVNETMIFWEGRRNEFIKGFTGVFSADGVVDKFFLKRRRHLLPGESASASASSSREPSEDELTSKSETDLETESDVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7Y1</accession>
    <name>A0A8H7U7Y1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2175041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10644546at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034508774" evidence="2">
        <location>
            <begin position="29"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="843"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="976"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1101"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1284"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1330"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="705"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="750"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="985"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1340"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1374"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1388"/>
            <end position="1452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2175041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1465" mass="154987" checksum="F023815AD2C7F250" modified="2022-01-19" version="1">MVITEGRLYKDLLPLLLGLAACVLNVSAGHKHKNDDQRHDKDDASEITGEELAMCNDMPYDSDIYSCLDGMLLPNEYKSKIRVLNLVHENEHHEYDGEHSKDENDVKSILKCGDMDFDPATCTCENDIICLKTQERCGAACFDAATHFCRDGEICLIEEHGPEDVIVPPQTAINQCEPGQDMCQGVCFYPETDYCCEGVVTPLTSTSAEYSTHTWPKPTNPVTIKHNEVTVITCNENALTTITTTIPATTSCTTTTDKKNAVVDVHCFYKPSSMVESSFNPCKIEATRTSDFPTSETKYEEAPTSTVCDKGYRTITTLTKCETKSDYVFGTGYTSCYVTTATPESSCLSPSSTTACDTTASTFEKCETKTDYVFGTEYTSCSLTTATPGSSCLSSSSTTTCDMTLATASTFEKCETKTNDVSGTEYTSCSLTTATPDSSCLSSSSTTTCDMTLATASTFEKCETKTNDVSGTEYTSCSLTTATPDSSCLSSSSTTTCDMTLATASTFEKCETKTNDVSGTEYTSCSLTTATPDSSCLSSSSTTTCDMTLATASTFEKCETKTNDVSGTEYTSCSLMTTTPDSSCLTPTSITDTSSGPPPSVTNFITTETITAPMSSVTVTKVTTPKTFASRSRDHHNSTIIQSSTEYDDSSSTISPSIKTTRSILVITTVHFEEVLRPSETLSSSYTDTFEATTTFTRCKHCSQDLSSTTSTLPPQSTLMFSRHTRSEPSRESTTTRLTGPSSSMESDSTKLSSALSTTQSTTTSSLDKSTVCNTCSSSHRLTTVHYEDIISVGKPTTTSCETCTISSKSTTVAQNNNISSGGPTTTACETCTSSTKLTTVSQSDNTYSGGPTSSACETCTSSDKPTTVAQSDSTSSGSPMTTACETCTSSTKPIAVTQSDNTSSDGPTSSACETCTSSGKPATSSHSDNTSSAGPFGSSATSACSTCSSSHRLTTVHYEDIISVGKPTTTSCETCTTSSKPSTVAQSDNTSSGGPTISACETCTSSGKPTTASQSDNSSSGGPTTTACETCTSSTKPTTFSQSDNTSSVGLATTDCETCTTSSQPTTVAQSDSTSSGGPAITSCQTCTSSSILTTVPYDEITTGGPQSTGIQDTVSSVTPSTMASSGGLTDMSSSVSPSHSIKRPNDEEVNPDPPFFTRPHSTSKTWDVAVNPDPPFFTRPATIRSDRITPTSSTPEFPSSFDTAVVSSSTLSGGSSAQSYTWPVYSAPLSSPSLPPSCSIVTVSVQTGPLPSDSQHSIPDNGWPVTSTMKCVTSGAVSTSLAMSTPSSLTSPSTVSTPSSAPLTSLSPPTIKFLDVTSTSCTTTPVATATSAIQKPPPPDKKTWDHGSGHGGKHHEGEDDHGGGHSKHDGHDWDDEKEEDDDDDDHWDKEGKNDDKDSHEKDKDDDKDHDSKHEDKDGDDWKDRDDHKDHDSKHEDKDDEDKKDSHKDDHDGDDDDNHKKHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U842</accession>
    <name>A0A8H7U842_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_009133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U842"/>
    <dbReference type="OrthoDB" id="2446221at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034781502" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2171472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="56477" checksum="E14349E30570FC27" modified="2022-01-19" version="1">MRPFVLAWLPVILCLTATASVIPAGNPVNVQNLDRRVPQQVDNDVMPLPDQHENYFDLRAASDAAGGPSDQSSSSSSEPTTTTTDESTTTNDDPTTTTHDQITTTSDLTTSTTHSDRPTTTTPDPITSTPNPTTTTTPDPTTTSENPTTTSDPPPTITSTTSSTSPLPPTTTSSLPTTTSSLPTTTTHSDPTTSSSPASDPTTTTTSSSPPPSTTTTEPPTTTTPDPTTTEPPPTTTTSNSEPPPTTSTPAPDTTTTPPNVITPTTTAPSHQTSDPVTTTTTSSTKPTPTPITSAKVTSYTSHIGTGTDVTIVVSTAMVTVTPTDPALLAGGNSGGSSSNSNAAIIGGVVGGVGGAVLLGGLGIFLYKKHKKNKEFNEPYSYDDDPDMSEFGPVTQRPLGSVGQHEGSDGGSYSQYQGQPPPLGNITQQAGPGGAYIAGTGGGFSQYAPTSPPPAGHVGGPGGGPYGGSGDYGQYPIGFIAPVDYRHSLSTGSQENDTAADHSLQSSRHESQYLGPGGGGHYRGPSDLSYEVTYPPNEVAAPPVPGHKPNTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U874</accession>
    <name>A0A8H7U874_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U874"/>
    <dbReference type="OrthoDB" id="409121at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017771">
        <property type="entry name" value="Cyanamide_hydratase_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03401">
        <property type="entry name" value="cyanamide_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569:SF1">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="62"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="237" mass="27093" checksum="EC5A6E84FB999232" modified="2022-01-19" version="1">MSTQIARELADSAIEREVDQFLRQSNIRPAKQFDIASIHVPESQVTEKTVRYVHDSVEPAIFNHSNRVYYLGAALVQDYLPQWKFDEETYFLTSLFHDIGTASKLQLSSVLSFEFIGGIHAREMLMEFGARQVQADEVAEAIFRHTDAKGGHTRHAGQIIQMSTQLDVLGTNPRWFNSNTVDQVVQKYPRLGFNHVFADQMRQEVAEKPGCLMCTRDSQAFIHQVENNPVMARYDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U969</accession>
    <name>A0A8H7U969_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_009059</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U969"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051704">
        <property type="entry name" value="FAD_aromatic-hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865:SF2">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="5"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2171398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="410" mass="45737" checksum="DC3B1F3479F9D169" modified="2022-01-19" version="1">MAPLNVLICGGGCGGPALAFWLARSGHHVTIVERFSSLRAAGAQIDLRSKGIEVVKRMGIIDAVRSKLVHEEGTSFVDAQNRDKATVMANTSGAGSQTLTSEYEIMRGDLVQILYDATKSDVKYVFGVSVDRFEQFEDHVLVHFSDGRSETFDLLVGADGQGSRIRKAILPANTPEPYNRLGIYFAYWFVPRTEMDTNICKIYHTTGSRAVMTRSHNEADTQVYFATKDDSEELRSIPRAPIEQQKEFWAQRFSGAGWHTDRFIQGMKDSSFFYCQELVQVKADTWYKGRVVLLGDAGYCPSPVTGMGTTASFVGAYVLAGEISRNPQNLSEALANYEKTLRPFVNEIQGINKTVIRSVFPQTQLGISILHFIAGLVCFLRIPELFAKYESNDKGGDWDLPDYPELKYNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9N7</accession>
    <name>A0A8H7U9N7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9N7"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2174845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="440" mass="49420" checksum="72253BD169D2C494" modified="2022-01-19" version="1">MIDQYQSSPSLHKPSSGFSSFQTVKFPNRNQPTSSYFKISLDPKCERLNNSNQTSTSTSSKVPETKKTAAEFASDQPSSSKRHLRKPRHPHDQPDENYLFRIFTPGEYDAMQSTDSTWRVTTSSDISGGWDGIPFAAEEYRSGKQPKFMGRPPKTKLPRHSVMDLRQAPSKKEADDKNEKLSIQKLRFAPPCGVDDSSTKHINKVVTRSGPVTVASLIDPVTRAYIRNPGGAALWTCAARGTERRLMLNVAKISDLRATLASLLCFLEEGWQGLHIYQVNCEPSSDSTHLILENGFDDDETKNRPAALARPFIVINKDILQKYTIRGYKEDAYDKGLNGPSDQISWMPEWYSISLTVLPFVYPMMSSTGMENDVALRMLIDAVVRQYMICGNGYHPLLYRPSVLEKLEKLQDPMDDILICAIVAGKLSLVNLTLQILLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9Z6</accession>
    <name>A0A8H7U9Z6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9Z6"/>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2172268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="227" mass="25585" checksum="9681DCB7E01C38F5" modified="2022-01-19" version="1">MTLISIVFYLTVDADITHAMDEELSYQSVEDFAGIEVPIRESLSKHQFELQDKEGAEEVLLTKQTDKEEIKVVFSVSSILDESADLDDVITTADDDKKTDETNTNGASALSLALRVAITKVSKKDKGTMAFDLIAKEDEVSLINIEYNQDRSFLLPESAYQSRRGSRRYLGPNCLALDVSLQQSFQSYLSNTGINQDVIKLIVDYAQYKRRKEYAAWLKNLGNFTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UA44</accession>
    <name>A0A8H7UA44_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxisomal membrane protein PEX16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peroxin-16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UA44"/>
    <dbReference type="OrthoDB" id="2021143at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013919">
        <property type="entry name" value="Pex16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08610">
        <property type="entry name" value="Pex16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2172104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="167" mass="18824" checksum="93945CFDE7C89009" modified="2022-01-19" version="1">MLNITGGRMLLHPSHPQRDVDPATLELDEDSSDFDPRTGGVHYHSNEEEEQWGHPEHLVYRLRGLGKLGEIAWIVRPLLYVVAVRKYGVQSWKAWLLSLSVDLLSRGMLACSGMSMNAVLTRGELLRPKLEAFCDATETRPVASIIAGVIRDYQPLWEDVYFYTAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAC9</accession>
    <name>A0A8H7UAC9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_004931</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAC9"/>
    <dbReference type="OrthoDB" id="5588835at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="213"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="619"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="639"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2172389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="649" mass="73021" checksum="B83C693562871F99" modified="2022-01-19" version="1">MSDQEISTVKVEACTQQNESNVLSETEVTAPTSTAGAVVEDEQKSLPLRLPITYDELSEDEVEPWMNDEKLQKAEDADTDDLLSDISPHHKTKGNKGANGRASNRQRRKKTYFDDTDANSDDAFEGTKKKTAPKRKPAAKKPNGKGKAVEPMINIAELLKASKPRKPAEFDPARVSELSAKYPDTYWEFHADSEHYMVDCINESEPLEALPNNISDQAAITGMALSKDGAMLASLSNIGAIKIWDIENDFKLLRKLRDHDEEHIDEFYCGKFLSDSQGLIAAGGKLKDRHRWSAEDDDNHILPCPIKIFDISTGKVVARLDGHSEEILCLKDVMFDGERYLISTSQDGYIFKWHLSEDWSTLLDAKKMDDGITCMAFTVSFVPNTGNKYFLAACDEHVRLYDFETCQMMQTFEDLYSSYCDCGKFIRWLDEDRYLEETKAEGSSEKDEQPYAWFITRGAEMCDMGDGISSTPNTCTLHKLVYPVTKGGKFELQEVKKYKHEDYHSNSWLVKIASNGRYLLAPTIYGQIFAFNMLSGQVTGILKDHEDLEVRDVMFHPYRPLIFSSGDDGYVKVYTYSETTLCSQLEKDLKVGNSINHSGDEVMAEVTDIKTESMIEVVTPAKKEPPSGRVTRKSRTSGDGDDVDVDVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAE4</accession>
    <name>A0A8H7UAE4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAE4"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="83"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2172434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="332" mass="37755" checksum="7C420A490019FDE5" modified="2022-01-19" version="1">MVFNHIAARIRLFIVVRFLRVVFGSMSSRMARKVLAGTTKPKRWQHPWMQFEPKTKSFFVGRNIASQSREQVKQRLQNANVVIFYIHGGGFRVGKADMYMTTFVRWIKAMEERGLSCVIYSAEYRLAPEHKFPAAAIDCIESYRSIIEDYGVDPKKIMMGGDSAGGALSLETLYHTCSDVQSHFNQIKLPRPGSLLMVSPYTGDEDMGSAIANLNTDYISEGTREKMIEYLPHNKDIEAFSYHVKKVSYAQFLPHHIVVVVGGIEVLRDVGLMFAKRCREENLRVSVVREELPHDWAMLGRLFTADHKVIKRAVMSVVDLAQDMLNSNQVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAT1</accession>
    <name>A0A8H7UAT1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_005770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAT1"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF21">
        <property type="entry name" value="DITYROSINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="68"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2174712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="497" mass="55452" checksum="4167D93FFBE0BA17" modified="2022-01-19" version="1">MLKPSISRLEQCKTIQERVQAEQSNDTDLEAASTTAQDEKPAISAPLSEVESDEKPYSAFSQIQKSIILAIVGLAGAASTLSSSIYLPALTAIQEVSFCSNYTIDFATTPELINITISLYMTADLLDNHDYLCRLKYWFGSCTQLFRLDRLANAPNYSALIVLRMLQAFGATSVIAVGAGCIGDIASPSQRGVYFSIYSAGPLLGPILGPIMGGVVVLFSSSFLAQNLGWRWIFWLLLILAGLIFIMVLFFLPESLRSLVGDGSGYANPTPQQWWKRRVLKKRTTENLKSHSKERSRFLQLPNVFRTFLYLLQPDVALYRDFKVVARQHGFNPAKLSRGSLPLDFPIFHARFHSVWIPLILFDVLIMIYGFLLWKEVHMAGPLVVHFFIGFCNTSLFSGIQALLIDLYPENSASISASNNFVRCLLGAASTATIQAGISAIGVHYMFLTLGLICFACNSILIALVRFGPEWRAQRMKREQEARRLYDDQEKLPLQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAU8</accession>
    <name>A0A8H7UAU8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_001592</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAU8"/>
    <dbReference type="OrthoDB" id="10264870at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22933">
        <property type="entry name" value="HFD_HFI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024738">
        <property type="entry name" value="Hfi1/Tada1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12767">
        <property type="entry name" value="SAGA-Tad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="391"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2178746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="419" mass="46637" checksum="D1363900E3BD06A5" modified="2022-01-19" version="1" fragment="single">GRRIHNTMVVTTVSVSTRPPAKTPNPNSHFTHATPNGRQDVLALKQQLADALGENGPLYWDSLREFITGKLNRQEFDYFAHQYVKKNNAHLHNAFILATIHNALSDAPPPLKQRAIGWAKRKRGKDGTYRGAAYQGREHTQKRLKIDVMSLSRVDREKLKALLKHGSGDKINLLRDKPLPPRISKPPSLPYSAEQLPNHISQVFTRGLYAPLCITSKELPSADGLRPRMTSIAYENNLLGGVSEDVLEAMSLALEVCIYHLSMSIFKHFLTMPFVEKKKKKIHIKAVISTTISKIRVNRTLGPKCASIRSIIRKEARPLSSQDADFGSPGPSSPVNVSSYSLASPAIGAQQFKKDSISGKPFIATKDLAFALELSPYTLVETPLCVEKVTTLINDTDDEEEEYDDTDDELDSDEGEFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBA0</accession>
    <name>A0A8H7UBA0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_005006</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBA0"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042453">
        <property type="entry name" value="WDR53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44666">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44666:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="10"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2173588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="334" mass="37119" checksum="B42CDB6393462056" modified="2022-01-19" version="1">MQEWTTSAKLVGHKSPVVCLDYAKKTFIAPDLLASGSEDQTCRIWDTRICKAVKAFAKQGAAVNSVKFATKPSVSNFYMAVGSKVLVFDLRNTDMILSEASHTYQESGDEINTIDINEKNNFLCTADDLGEVKVIDLESHKLYKQFRSKHKNLCMEARFRPRKPWELWSGGMDTAIMQWDISRGTVSSVYDTNNTDPNAQQMVNPPFVYALRFHPNGEWVASGLGDGSVHVLKLSPKSKKIEEMRLGDAHGTIVNSLAFEGQSKQPLLWSGSANGTLAQWDLNDPTKPLQQCKIDMAKLNWIENFVDPNSQGNILAAAGITSSNEGAIHLYKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBK7</accession>
    <name>A0A8H7UBK7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pyruvate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_007554</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBK7"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="13">
        <location>
            <begin position="8"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="11">
        <location>
            <begin position="220"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="12">
        <location>
            <begin position="411"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2176900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="64109" checksum="82B1242F5FEDF451" modified="2022-01-19" version="1">MPQNSISIGKYLLYRLKEVGIETIFGVPGDYNMVNLTTRLNVLNCRVFVATNSLHMDDKDLLWGHDANELNAAYAADGYARVQGVGALVTTFGVGELSAVNGIAGSYSEMIPVIHIVGMPNTKSQASGAVLHHTLGNGDFQVFRKIFSEITVANTILKEDTAMQEIDRVIRHSIINVRPGYIGLPIDLVDVEISVPSWPVKPIDLKLPENPEKTHKAALKDIISKIEQAENPIILVDACALRRNMKKHVHELIKVSQFPTYVTPMGKGAVDEADKCFRGAYAGNVSYDEIKKEVLESDLILEIGALQSDFNTGGFTYHVDADKVIAFHSFNTSVFHATYEKVAMNQLLPDLIKNFPNKKGKQLGPRPEGPKADQSSQVIDHTYFWANIPRFFDPRPIIVAETGTSSFGAINMKAPKDSIFVTQILWGSIGFSVGAAVGAAVAGRKQDRRVYLFVGDGSFQLTAQEVSVMLRLGLTPVIILLNNDGYTIEKLIHGDGRDYNEVPMWEYSKTLQYFGSELKRNLKSGIQSKVGLQLKVETRKQLEEAMEKTKSQPDKIHFLEVCMPQMDAPRELLMQVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBP6</accession>
    <name>A0A8H7UBP6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_001334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBP6"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10919">
        <property type="entry name" value="CE4_CDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052740">
        <property type="entry name" value="CE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985:SF3">
        <property type="entry name" value="CHITIN DEACETYLASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034038575" description="NodB homology domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="67"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2175687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="494" mass="53659" checksum="6C94527036BFA591" modified="2022-01-19" version="1">MISLIAAACLILPLLLQVAAQEGQLIPGSAALASGPEYSCDPSKCVAPSCYCASKDPPAGMSPSDTPQFLSITFDDAIQPQLLETAYKMLNVRNPNGCKAKGTWYVSNQFTDYASVQQWYAAGNEVADHTFSHVSSPSAQEIESCRKALNAYSGIPYGKITGFRSPFLNYSTETLKNIKDQGFIYDSSASSAGGRDYWPYTLDYGLANDCWKGVCEASARFPGMFEIPMYTVTDDSNTEHLMDTYLNGSPSDAKKWTLKAFDAHYSGKKQPFGIYVHPTHLTTYPGMADPVEKLNNIVEAIQEIAAKPDVWVVTNQQLIEWMKKPVPSSQMGSQPYMGCSAPKINQEICNGLDDTGITPTDAGLLNTCSYAESFFKSCYNCPSKAPTVADPLPGSATEKGQTGYRAPLPDNCDSVWWDPIAAKCLCSTSDCQYKDTKIPVAGNKKDLAKSTEKSNESNANGEKSNKTSLSSRLSVDIQALTGYITFMLVSAYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBQ4</accession>
    <name>A0A8H7UBQ4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_005144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBQ4"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034068058" description="AB hydrolase-1 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="59"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2173724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="307" mass="33804" checksum="508BCDCC4A7E323D" modified="2022-01-19" version="1">MHKLYILFLVITVLSIFVSGGSPDSSWATDLLLHNSLAWNDPPIQYWLSGFHHNPYGDIIILSPGAGLDHHSFDPQVLPLVIAGYRVITYDPRCQGLSQWSNPVAKSNCTITFDLMLQDMNQIFSSLAISPEKQVIQAGLSMGGMLAQQFSKVYPNRTKALIAMDCGTNEELLPWMQYYLDTPLGTLIADDNNTSFNAILNTSNRTLVRQEIYNELSLSGDAEIVKAMKACASAVSNDPGFTRLQIPELLIYGQLDSLTNASMIEWYARDQANPHISLISIPSAGHISSLDNPSAVNQALIQFLASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCC6</accession>
    <name>A0A8H7UCC6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_004377</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCC6"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056229">
        <property type="entry name" value="Ig_TMM62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056230">
        <property type="entry name" value="TMEM62_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14795">
        <property type="entry name" value="HELICASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14795:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24384">
        <property type="entry name" value="Ig_TMM62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24394">
        <property type="entry name" value="TMEM62_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="628"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="671"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="707"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="69"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM62 Ig-like" evidence="4">
        <location>
            <begin position="358"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM62 C-terminal" evidence="5">
        <location>
            <begin position="501"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="771"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2174354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="796" mass="90271" checksum="E6FC65B3CE96E84E" modified="2022-01-19" version="1">MLLSPISWLALIATILCIIRGIYLDKWATADLRGSGPHEAHWNREDPNRWTLNDGSLEIGTEPDNIFYFVQISDLHISQFQSKGYTIHFLHFLKSILPAISPEFVVVTGDLTDAKDARRITSSQHVVEWEVYQKSLEEAGVSDGWYDIRGNHDCFDVPQWSDSANMYKDHAVSGELLEKGQGVYEWELEKGSGRYQFVAFDACPKRGPSRPFNFFGYMPAKGMNHLANSIIGKEGDKSYNHTMVFAHYPTTTVAFGVSDKGYTYTDLAKQFSVYFCGHMHKLIGGLGDELKGYNAKTHSLELELGDMKDHAMYRIVAVDHDLISFVDVELPLPQIPFSTPEIPKVVEGKRLLPDKIDMPPVVLITNPKDARWILQYKEPVARIVQSRALRFLVFSGENDPKSLQVKITIDGIVHPYPAQYKGKGDPNGIAKGYMPLWISEWDPQNFDDREEHVLRITVTDSQGRKGVDESIFKVNGARIDINGGAGEWIIWTKFSFSLKLCCLVAISSILAILLIPKIYSDFTPPGTERQCARRPILQRIHHLSNEPKTLANRIRYHVWLWTLRCIDLPRNSPIIWTGTLTYTLMLISLPWFKGEFIPVAQNSEDRYGLFYLSGIRLSGEWIPLADTWMFALFELTFGLAAFVLVWIWRATDSADLRCSGTSRIRTLNERAWFKALVVIMWLWRMSEVLALGSFYGGFWPTLVQNIIIWWLLFAGICIASGKDGILARPSTKERISAIWGRCSICHLNDEASEEADVRRSLLDNADEDPGSHSSSSCSTNESIQGFNAVKIRKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCG1</accession>
    <name>A0A8H7UCG1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">m7GpppX diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Decapping scavenger enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Scavenger mRNA-decapping enzyme DcpS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_005692</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65388"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58285"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="EC" id="3.6.1.59"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.59" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCG1"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140932">
        <property type="term" value="F:5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000006">
        <property type="entry name" value="m7GpppX diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.40">
        <property type="entry name" value="Scavenger mRNA decapping enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008594">
        <property type="entry name" value="DcpS/DCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011145">
        <property type="entry name" value="Scavenger_mRNA_decap_enz_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978:SF0">
        <property type="entry name" value="M7GPPPX DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05652">
        <property type="entry name" value="DcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028973">
        <property type="entry name" value="Scavenger_mRNA_decap_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102860">
        <property type="entry name" value="mRNA decapping enzyme DcpS N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2176452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="305" mass="35924" checksum="D99BBA40451C9B37" modified="2022-01-19" version="1">MQEAELLKRFQFSRVLSQDSRAKCVYLLGRIPNESDESDNAIIFFEKHHFYESELAILPTERITELVDTEKNDIYLWTKTNLAKDFSRPDVNIRLIYPATQAHIDKYTTQTFSIIRETIKSYNEITKPYIEQQPYKRIQWVHNILDGTAESERVLLRDDQDVNTGFLLLPDMKWDLRTMDSLYLVVLVLRRDLRSIRDLNSNHLPLLKNIREKVGDFVTATYGVQRDRLRMFFHYQPSYYHLHVHITHTAYTTAPGIIAGQAHLLDNVISNIEDVDSSYYQRITLPFVLGNNHELCKRHLQDPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDH4</accession>
    <name>A0A8H7UDH4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_001787</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDH4"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2178940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="288" mass="31413" checksum="179BAE93665D67AE" modified="2022-01-19" version="1">MTQDKTLQNKVAVVTGGARGIGKALVTALVERGAKVVIGDLLEAEGKQLVETLNEQNSEKVAVYLKTDVTTWDDNKSLFKLAEDEFGGVDIACMNAGIGEVPDSIFSPLEGDFKSLDVNLNAVIKGNKVAVLHLNKRGGGVIVNTASVAGFLTHGAFPLYNASKHGVVGWTRSLDNLREIANIRVNMVNPYWVETDIIKSITSLEFLDVAPKVPMATVIEAFMKAVEDETCHGETILALPDGIHLHPRVQLWESCYNKEMLTVGQQSQKHHIEAMKIALEQARARENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDK5</accession>
    <name>A0A8H7UDK5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDK5"/>
    <dbReference type="OrthoDB" id="15893at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039196">
        <property type="entry name" value="Fmc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28015">
        <property type="entry name" value="ATP SYNTHASE ASSEMBLY FACTOR FMC1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28015:SF1">
        <property type="entry name" value="ATP SYNTHASE ASSEMBLY FACTOR FMC1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="143" mass="16505" checksum="97C5FC7CCF47C498" modified="2022-01-19" version="1">MLSTYRQLLREIRQQYSKVAKHNSFEQELKTAFREHRQVADQTRLIELKENAENTLLFLKSTRQHKELLARYNPALMEQSKRIELSANRVGLNLPNQYDPKNPAPLEQPKLQPQEAAVQERVGKAFGNDTTAASSEPSQAKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDP6</accession>
    <name>A0A8H7UDP6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_005356</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDP6"/>
    <dbReference type="OrthoDB" id="1166329at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2176123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="152" mass="17404" checksum="FBE209636239723C" modified="2022-01-19" version="1">MSSYLTAAPNRIYYNYWESLSIHDLFSILILNSQSFTHNIWTNHLSFLSNSLYSKGRVLGYERAKRNQNENTSLIQIEGVQTPSDAQFYLGKRIAFVYRAKREVNGSKIRVIWGRVTRAHGGNGVVKAKFRNNLPPKTFGASVRVMLYPSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDW0</accession>
    <name>A0A8H7UDW0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDW0"/>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="411"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="468"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2182061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="696" mass="77021" checksum="AAD99C808A5668D8" modified="2022-01-19" version="1">MPYESKQQQDNSSDYTRSFESHHSQNYGQFNPEALSPTTLQRFMESDKDFDQLFDSNLDNVMISNGHQFASNNPWLMQHLKPHHQNNMVDSSSIPSQDTMKNDMSRQYTAAYGSDYGADGYGNMSSHDYQDILLSDPSFLQQQQTLQDHQRRMQEQIMAQDQFLDVGSTPQYGVSPPVSNLSAMFNHTEHSTSPVNHGRSPSKTDQREKRLSQPVQGGVRITFDQPTSPSGGGHNNRALAERRGSPSLSLGSFPSRAGPLSSGPLTSPVDHQKRQGDFQARFKVNYARKASLNSQQQAQAQTMLQPTTQHGSFQEAPTFRNPFASLPTTPADVNNDIPNPLDDMSCERRRSISLPPSAANNRIPMPGTPPPPPKANPIPIERVSRPQVASMSMDAEEHHRRLDEQLQKVNFDDITVSELKEMLRQRGKPATGKKATLIQRLMDERDLLNAQRNGVAIPRSNPSSFTAGSPINSSSVPNSSPVIGSPFSQIQKSIANMSIGSPPMSAHSRRFSPYGAPKSPRLAPSQGSPKQLSTSVPSGFHSNYRSHTPHHHHTNSSQFIRHNQHASLYAPFVPSGLGTPDTELEANPFDMAIEDQGQYGVANDNNKNYPDQMIESFSPNTSGDSNFTSNLHDLLQQGYVPDSISDSGMDNQYVPQQTVDQLFGGMPELSFENSGSIDLGLNRDGDDSFDSFLKWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UE32</accession>
    <name>A0A8H7UE32_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF962 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UE32"/>
    <dbReference type="OrthoDB" id="5511466at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34205:SF2">
        <property type="entry name" value="DUF962 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2178192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="10122" checksum="E3BA6F12A028814B" modified="2022-01-19" version="1">MSKIVNHNYSQRTEPASGFKTLEEFYPFYLGEHCNQINRRLHITGTTLSQIIIAYALIRQKYKWIIGAVVQGYAWAWVGHFIFEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGD7</accession>
    <name>A0A8H7UGD7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGD7"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF76">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="12"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="469" mass="53622" checksum="4C61D3D9181FE7F1" modified="2022-01-19" version="1">MLRFLDYLSNTEKVELLKVAVKETDTAGNGLFASDELDCHKGSSLLTIPSQLIITAQTAREFFKEKFPAIYQELDEVSLGAVKERFILLAFLIYGHSNPSEFPYQAYLDVLPTATDFEKWHALYFDDEHLKIMDGSSLAASIEARHQVLKKEVHNFRHHVRSFPEDVSLELWKWADTIFWTRVISIKSQHSASKIPSDSQSDYALVPMIDFANHSLKPNVRWEINEDGDFQLFPKDDIQIKAGDELFLSYGDKSNQELLFSHGFCIPDNPTSAKFTISAASLLSFDEDSYQAKFHWLRKIGYQNLALTLEKEAQGMWHPLLKAGWTVESVKLLHFAVLSLSEDDLIVTTEEDSVTEDGVNIVFDNVNLKDMDQSFEIIQQHKNYPVYQLRTVLILSDALEYHFNTLAMSLQEQDDSLDQNDQTKSYISMYATEELELLSKALTIMDEEKAKLAENEVVITYLGQDEDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGG6</accession>
    <name>A0A8H7UGG6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_007077</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="161570at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031099">
        <property type="entry name" value="BRCA1-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041292">
        <property type="entry name" value="Tudor_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13763:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13763">
        <property type="entry name" value="BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN BRCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18358">
        <property type="entry name" value="Tudor_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13771">
        <property type="entry name" value="zf-HC5HC2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="1035"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="1261"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="345"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="706"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="706"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2182150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1904" mass="217927" checksum="D373227657BED5E7" modified="2022-01-19" version="1">MDPIANFPGYHTGRKYNKASRINNGKIAKTSTWVEKVHPQAHVQVQHRLPLAYAPGKQQDRFDLSAASKFTTSSDKPRETRKIFSGVRISQPKSINRKIDEVFRVSKNASNGPKKMIMSLKRQHDPIDTVIEIENADKCSRSAYHDTESRDENAGSLENKGLEFANSENQSISTLSTSEKYRIHNNKRTRWDVGSYKENYKIVEPTPIGEKPSPSHSDMDTETSMIQPTDVEIPSYDCDDELQSDDDVVGPWHNSEEPIIESNEGECSHSDSRVHSTTQNGHPQFESTIDQLKINADSVDTDQGIKLLANEPQSTSLNAMNVNEDLMKTERRNIKIIDRVDARKAHRNEKVKPTQPPTKSSFARKTDMKMRQKKTGTKKGKGKKKAKKIPKKSIHTQEEYSTTGAFLTRGTVRQLADAHGFQPNSFNYHYMQLVEVLNINGSWYSGKLMEMDSGKVRVRYTDWKDYEWIIIGSRRLRPINEPHSSNIIDLSETQQNPPDVKQVEATVVANAQAPANELNESLQILSGHAQEEIAILGTSIDPPLDSSNLLLSGENKSEAAQSRKRVVPQPYEYRTTGAFATRNAMRELADSHGFIPNAYGFTYQCQVEVQNVKKFWENGHLVQMDKSRVKVRYDGWDEDCDEWFPIGSRRLRLLARPVDENVLESLLIFDSNPEMQDAHKASGKHKVIGPNDEFWLKEARRLQEIEENKKRRGKAMDVDPDNAGETNVENSKTQDTKPLEYQPFSPNIYGYYLMQHVHILQMDRKFYEARLVAMANGNVKVHYCGWNAKLDEAVPCGSPRIQQWKGNDINVCVDPDYAAGATSLTSDDAVQKMLSPTDSIQPSIPSFVRRSMRERKPTYKCREESPSELSTALISLHPFGLPDDLIDGRNRHRKIKDQIIELAEYYQEPEVGENQTVERSWVIYCKQCKIVIKKFRYYCTYCEWPTDGQLVQNFDLCLRCFDQDFPFWHDHPRSGFAVQAVLETKDDPQDYISPAWEEDVIDDSYVSDTEDNILNSSAPIESDEGYKYLKQWRKRKICALCNDDDITPDLGGFVGPFIIETFNRQGNEKKKTFWIHDACGRYSPEVVVTKENKWYNVTVALRRGRGVKCGACKEKGATIGCFDGDCNKSFHVPCARKPVNYFKKGVIFWCPGHEEYYNKKDTYVNIFHCDQCNKKMEGETWFSCLPCSQEYFTTYDICSECYERNHCSGHEHDEDCFEETSMAIIKEMEAEKAAEKARKKAEARAARAATKKCKMFPRRDQKGGLYCSYCNTQETVRWRKGFDGVLMCEACFELASLDLIQDELPLVLDDQSEERYVASIEDYSHKPYLTREALSSNKFDDMKSNAIRLASYAPTEVQLFSLSFDSTYFDIPGRAPRWASHSGTDYHGTWLPQTVRRAILRHTRKDERILSNFLGRGTDAIECFLLQRRCCGIDINPAAVSLSQRSCSFEIPPGLTTAEHRPIIVQADSRKLTGALFTNESYDHILSHPPYKDCVAYSLHIEGDLSRYTNPIDFQGQYEKCVKESWRLLKMGRRLTLGIGDNREHCFYVPVGFQLIRLYMNNGFELEELIIKRQRYCSAFGLGTYLCVQFDFLVFTHEFIATFKKVLPKGNDTMDSYDGNHIRVTYTTREIPRSPIARKSVVMGTVWIFKPSAKHSFSQLCTSRMVERFGKDESNWEHIEIELSSDQNSTDCQPSVYDNHAIQETEADTLLLSNYELERQRRIEENRIALLQLGLISDLSEESSDFSHYEAMIRKAALPAPSPLSLRVIPHIPSQLLKPEYLPLYRENIVQMAQESVGKLAAGGMFIVGTQDYREPTGKLWPLGVLIMEDINRNIGEKHLKLKEMVVTVPEGYSKDRSKVISYENYVQDICLLDVVGETERLGLNVPIVHAVYLIFMKMDNSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGI6</accession>
    <name>A0A8H7UGI6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydrofolate synthetase</fullName>
            <ecNumber evidence="9">6.3.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_007137</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>7,8-dihydropteroate + L-glutamate + ATP = 7,8-dihydrofolate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.12" evidence="9"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGI6"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.10:FF:000011">
        <property type="entry name" value="Folylpolyglutamate synthase/dihydrofolate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF0">
        <property type="entry name" value="DIHYDROFOLATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur ligase central" evidence="10">
        <location>
            <begin position="27"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2182210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="435" mass="47434" checksum="821009412FAF0FC7" modified="2022-01-19" version="1">MDLGLDRIKSLLKALGNPEKSLQVIHVAGTNGKGSVCAYIASILDSAGFKVGRYNSPHFITPSDATQINGQVLAAEDYQSLIDRVSTVDKKNTCNASSFEITTAAAILWFYESRVDIAIIEVGLGGTLDATNVFDYPLVSVITPIGMDHASILGNTIEEIAAAKAGIMKSQCPVVISPQPEAQVMDVLKAKAHQLSCPVILSPTAAWSLNSDEPAWATVKVSGPDDANTETYQFKIPLYGDHQLVNAATAVSTIHMLKSKSIEFGRKISIQHIEEGMAETRWRGRLDLLTMNEYPWLGSNYNIKEMFVDGAHNPPAAIVLRQFVDQQLKARGLDKVHWIVASTEGKDLRELLNILLRPQDSICAATFTQPENMPWIYPMPQSNIIEAATTITDNCTIESSLDAALHTAGKLDPSKQLIVLCGSLYLVADLYRLHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGY2</accession>
    <name>A0A8H7UGY2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="16">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">INT43_008895</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="16"/>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254570at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001027">
        <property type="entry name" value="dynamin-related protein 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF235">
        <property type="entry name" value="DYNAMIN-RELATED PROTEIN DNM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12 19" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 18" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="22">
        <location>
            <begin position="577"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="21">
        <location>
            <begin position="1197"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1069"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1141"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1079"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="18">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAG2181312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1284" mass="141836" checksum="A9DAABA00E9AA4F4" modified="2022-01-19" version="1">MSLVAKPTALLQQLETFLNQPRLARFKNLVFVLVVIHYWSRLYSKVIVAGPTRAAKDAYAYCAKLFFRQLRRLPAVQAKIDAELSKTLKDLEHSVLSREGNTKRYLALPSQGMTKDEVRENLKRFQSMEDVDWAGGRVSGGIYHGGDELSDICTEAYRMFAVANPLHPEVFPGVRRMEAESVAMVLNMYRAPKTGCGVMTSGGTESIIMACKAYRDMGKDLKGITNPEMVIPETAHAAFMKAAGYFNIKLITVPVNPVTMQADVKSMGRAINRNTVMIVGSAVNFPHGIADDIVSLGKLAKRHKIGLHVDCCLGSFVMPFLEKAGFPTTRFDFRVDGVTSISCDTHKYGFAPKGSSIIMYRHPSIRKYQYFLCADWTGGIYASPSVAGSRPGSLIAGCWAALMTIGEAGYLDSCKKIVGARREIQSGVEEIPELFVLGDPIGPVVSFGAKSPLNIYDVGDKMSKRGWNISALQNPPALHVSVTLLWVPSAKPFVADLKEVVAGLVADPSSGNGNTAAMYGTAATIPDKTIIEDVAAGFVDLLAPLPSFASTHYNMENLIELANKLQDVFSTISSSDGLDLPQIVVVGSQSSGKSSVLENVVQRDFLPRGSGIVTRRPLVLQLITLKDNAARDYAEFLHIDKRFHDFNEVRGEIEKETTRIAGQNKGISRMPIHLKIYSSKVLNLTVVDLPGLTKLLLLYQIPVGDQPTDIEKQIRSLVVDYISKPNSIILAVTPANQDLVNSDSLKLARQVDPEGKRTLGVLTKLDLMDAGTNALDILTGRAYPLRLGFVGVVNRSQQDILTNKSMKDALKAETDFFNQHPSYKRISSRCGTNFLSKQLNSLLLNHIKEKLPEMRSRLSSLIHSSEQELLQYGDPTWTAANVPASTLVLRLLTNFASDFVAAIDGTSATISTKQLYGGARIYYIFNNVFGQALESIAPCLNLSNHDIRTAIRNSTGPRPSLFVPEIAFDLLIKPQIKLLEPPSLKCVELVYEELMKICHSCGSKELQRYPRLHSRMAEVVSELLREHLSPTVTYVGSLIAIQRAYINTNHPDFLGAAGAMESLGIESKRKKKMEKKRNMSVQSSTSTASGSPLIRPQQDGPALNGLTVPRLHDDGHLGMSDDGSQKDSFLNYFFGGSSKQDRPALGPQDLISNSQYVPPPSMNNMIEAELERKMEQGTIDGEEMFTTPTSSREEIETQLIRSLITSYFNITRKTIRDSVPKAIMHLLVNNCREVVQNRLVTELYKENLFNELLQEDETMAAERQKCVMMLDMYKKAFSMMNEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHD2</accession>
    <name>A0A8H7UHD2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHD2"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="2">
        <location>
            <begin position="33"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2183125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="134" mass="14138" checksum="4869495D94912C56" modified="2022-01-19" version="1" fragment="single">AIPLPNVEDSLKAAGQAAEKGLSSFLKLGIFSGQATWFKPVTEGGPTGACGPQEDNNDMIVALNAAQYGPMNKKSKYCGKKILITGPNGKTVTATINDACPGCKKNSLDLTPAVFKKLGDMNTGILKIKWHFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHL7</accession>
    <name>A0A8H7UHL7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor SPF27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002594</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPF27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHL7"/>
    <dbReference type="OrthoDB" id="205794at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008409">
        <property type="entry name" value="SPF27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296">
        <property type="entry name" value="BCAS2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SPF27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05700">
        <property type="entry name" value="BCAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="135"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2186156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24744" checksum="4596050F1E2F5FB4" modified="2022-01-19" version="1">MTEINGHAGDFDSLPYVDRQLELEGMKEKVDLLIEQEMRRISRKDRVQLPKDITLFKDDPVLSSEWARTSKQKPMATLDISRYDVAPPAGKDKQSVEAWQAAVDNSKAQLESQTLRLFNLELLQKYGSNAWKVHNFQLEGQLKQLKYNVEEKKKEISELNKQRKFEQTEGGTTLRNLESKWSDLVSQTLQVEVACAALENELEELKRYENSLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHS3</accession>
    <name>A0A8H7UHS3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lanosterol 14-alpha demethylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_006566</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHS3"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2183560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="57403" checksum="BFB073A52AE9F1A0" modified="2022-01-19" version="1">MLVDSFGSIALYGSLAIITGFAIHILSQLVAKSDPKKPPVVFHFVPWLGNAVVFGMQPIKFLQDCQKKYGDIFTFKMAGMTITACMGADGNQFVFNSKQNLSSAAAAYNHMTKYVFGSDVVYDAPHNIFMEQKRFIKAALGADNFRKHVPMITSECNEFFEKNLSGSTGVVDAHTMFSKLIINTASRCLMGKEIRSNLDDGPVAKLYYDLDQGFQPINMMFPNLPLPSYKRRDIANQKMTALYASIIKRRRDENDNIEQSNSDILQTLMESSYKDGTPLPDEHIAHMMIAVLFGGQHTSATTATWTMLELAARPDIMKELRQEMIDKLGSLKAELTFDNLKDLTLLEACVRETLRLHPPIFTMMRKVIADKLVYEKTGHTIPKDHVLFAAPGVTQVDDKYFNNPTKYDPYRWIEKTDPVHAMEVGADANEDYGFGAVGISSKSPFLPFGAGRHRCIGEQFGYLQLKAVIATFLTTFDIDYPEGSKGVPEPDYTSMVVIPKHPCDIRYKRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UID0</accession>
    <name>A0A8H7UID0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="32">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">INT43_003963</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="30">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="24">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0585 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000024">
        <property type="entry name" value="Probable serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000741">
        <property type="entry name" value="Putative mitochondrial dynamin GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010342">
        <property type="entry name" value="DUF938"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056495">
        <property type="entry name" value="LIS_MGM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06080">
        <property type="entry name" value="DUF938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24550">
        <property type="entry name" value="LIS_MGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18 24" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="27">
        <location>
            <begin position="240"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Dynamin-type G" evidence="29">
        <location>
            <begin position="912"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="28">
        <location>
            <begin position="1478"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="833"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="25">
        <location>
            <begin position="838"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="KAG2180174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="32">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1585" mass="179759" checksum="CAC8336E15E41127" modified="2022-01-19" version="1">MHAVQNILSERKLLEQIEHPHIVNLRYAFQDDENMFMVLDVMLGGDLRFHLDRMGCFREEQVRFIVAELSLAIHYLHEHNIVHRDIKPDNILFDDKGHTHLTDFNIALKCRQDKLMYTVAGSIAYMAPEVVMKKGYSNAIDWWSLGATAYELLFGRRPFRGNSNDSISKAIAYEDLKFPDNVYDILSSECVDVITKVCVEATIRSHGLPIIKQFMCKNPADRLGVGDEGYAQLIAHPWFRDIDWKQIEEQTAEPPFSPDSKRANFDVVHELEELLLEDTPLKTRRRKKPTDTNTSSQHRSFSQQWTADQCRDLLNMEKKFQDYDFTKQHNANEVRLGTQPSGVNEISGNLGHARGPSSNNVSNPSSTIKPEEDTDKNMCMKALTSVPLWRKTYAVSSKPVCSIPRAFKQGVNGCEDFLDAKRIHTTRNLHMNAENQRLRAHLKEYYGVDVQVATDGRVEFPWTAWNSDDILKQLLDKFSILPNGSSVLELASGSGEHITKLAKKLPNITFYPTEGDSMLLPSIEAWARHNEVSNVATPVVLDFGKEAFSKSVNGAWVINVTHITPWSDTVALFANMAKVLEPSSWFGLYGAFNRNGQFTSESNEQFDKDLRRRNSEWGIRDIDIVRAEAEKNGLTLDSFHEMPANNFMLWFLSYPLAPMLQSTVAVARPAISRSLRAPVTRSYHRPAFFISPHHHPLRVPTFQRSTILPVKATSTIIRRPLTFSAAPRIILSVGRLPLILAGGAAATATIANSKLQDWNDSAADFLLGVKGVLNTVQEDIISFDLRVPEIHIGVPEFVKDILRSKDSPSQLYTFGQLKHEDEENVAQKLQRNEEKDNQGGGGGGGSGGSGLPPTGAAIAAATVLGYGEEDEYQNKRGKSKDTIVQHDEQFMMLTKKLIEIRSILLSIDHNETLKLPSIVVVGSQSSGKSSVLEAIVGHEFLPKGTNMVTRRPIELTLVHTPNSDEEYGEFPQLELGKVHDFKQIQKTLTDLNMAVSDAECVSPKPIELRIYSSSIPDLTLIDLPGYIQISNRNQPESLKLKIEELCEKYIREPNIILAVCAADVDLANSTALRASRKVDPMGLRTIGVITKMDLVPASNGAAILRNSEYPLHLGYIGVVCKAPDDVDGNMTSALIRNEDNFFRSRYEFNQRGVNVGTATLRRKLMNVLEQSMGRSLYSIVDAVQKELEEARYQFKVQYNDRRVTAESYVAETMDTLKHNFKEFATLFGKPQVRHEVRTMLEQRVLDICAETYWSDPKVSELPKASPDDIYWLYKVDLASAALTKSGVGRATTQLVVDILMNNMDRLAAGEPFNYHEETRKQVSTFTREILRTKYLTTSDQVENTIKPYKYEVEVTDLEWQDGVKRSVALLEKELEMCDNMANNIKNAVGKTKLRGAIKFLLDSEREDQRRQEKVRQQHDEGSEPYMEYTSLSDEEEAIKPLYNPKLLEKAKEALFLRDRAMILKYRIAALKSRQCKTQDNKQYCPEAFLNVIAEKLTYTAVMFIQVELLNEFFFQFPREVDNRLVYDLDRQQIQRFARENPSIMKHLDLQERKAKLEDVMDKLNYLVRKQADRQARAKMGSFATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIZ9</accession>
    <name>A0A8H7UIZ9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_000808</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIZ9"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="8">
        <location>
            <begin position="441"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2184895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="659" mass="74946" checksum="F1B42EC1CD4FFB41" modified="2022-01-19" version="1" fragment="single">AGTFDRVADDNEAVLRQIFENNFEDLKYINGNAGISENQRVKDKQVFEKAKNYYGSCLDEQTINQLGTSPLKPLLENLASIWHTHSGEKISTITNALSYLISIGVSPFFSIYADADSKNPGVNTLYLQQQGLGLPTKEYYSVPATMELYEKILEDTWKVTMSNGQGTTYDPDTDIASIARKIVDFEKKLASISNSTDELRDPVATYNPVRIDHLNELTPNIGWSQFMSERQVSSKPVEAIIVESPIYVQKLGKLIEETDLMTLRHHFTNALLFSAINSMSEEIRAPYAKLQQALEGNKQVLPRWKTCIRNLGYALGQLAGRYYVLEKFGADSQKYADIFVHNLRDSLEERFYNQNFLDDQTRATALEKLHKIQQKIGYSQSDPNIMSPESLDNYYQGISSTPLNYFENHLSYRVWENRQTWSLYGMPVNKLRWAMNPQDVNAYYSPLINEIVFPAGILQPPFYDANYPDYLNFGGIGAVMGHEMTHGFDDTGRLYNAVGKIESWWTKETEVKFDDKAQCFIQQYSNFTISGADNKPVHVNGKLTVGENLADNGGILISYYAWKARSIASKISEINGPNSNSLLMGLDHYTPEQLFFINFGRVWCQKIRPEKSLKRIYTDPHSPNRWRVNGVAQNSVEFAMAFGCPAQAPMNPDKKCHLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJ14</accession>
    <name>A0A8H7UJ14_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJ14"/>
    <dbReference type="OrthoDB" id="2571149at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20273">
        <property type="entry name" value="Complex1_LYR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046896">
        <property type="entry name" value="Cup1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="303" mass="35091" checksum="9418C98207CD0A3F" modified="2022-01-19" version="1">MNVPPVWQAYCKLRPSLAFEIPFKTRVLYRSLLRESAQFNESKVCTFLRTTIRERFRFHKHETSARRALITIQEGQRVCVKRLLKRFRPIVDIGFFNKALKVMRAALEGNDPYYRRIEAMANAEIGPLAFVKKKICRIANPAKRHLATLDIRPQSAKSQRPGVAIPLPEYIMQVEQSPSKEANAAELSKRKPYMRAIQVQCATGRKFMRVRGWIQPQKTSMMIKASVMTNQRRVDRIKLYEEYIRLLNGEADFLKELGVDNRDIRDTTQTIRAVLADAYKQFNQPQKGTSTMMKEGNSKHVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJ35</accession>
    <name>A0A8H7UJ35_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-oxoacyl-[acyl-carrier-protein] synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_006615</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 11">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJ35"/>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000015">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000024">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005589">
        <property type="entry name" value="PRK07314.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712:SF336">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="POLYKETIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="12">
        <location>
            <begin position="1"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="10">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2183607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="423" mass="44796" checksum="BB7A95F8B4C4E647" modified="2022-01-19" version="1">MRRVVVTGLGMVTPLGTGVKAAWESVINSRCGIISLKDRPGFSDLPVTIGAAVKPGSREEGGFDASEWLDRGDDRTMALFTKYAVACAKQALEDSGWKPKTEEEQERTGVCIGSGMGSLEDLYSTSIMFEASGHRKVSPMFVPKILINMAAGHLTMKFGFKGPNHAASTACTTGAHSIGDAMRFIQYNDADVMVAGGSEACIHPLAIAGFARAKSLAASYNDDPEKASRPFDKDRSGFVIGEGAGVVVLEEYEHAKKRGAKIYAEIKGYGLSGDAHHMTAPPENGDGAARAMRRALAHAQLTPADIDYVNAHATSTPQGDVAENRAIKSIFDGHWDKLSVSSTKGATGHLLGAAGAVEAIFTILAIKNNILPPTLNLHGYSDDEFNLNYVPLVAQDGKEIRAALTNSFGFGGTNASLCFTKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKQ0</accession>
    <name>A0A8H7UKQ0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="16">1.3.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">2-methyl branched chain acyl-CoA dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">2-methylbutyryl-coenzyme A dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">INT43_007354</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="31">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(2R)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65296"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156439"/>
            <dbReference type="ChEBI" id="CHEBI:156440"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:65297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48256"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:88166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:48257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57336"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:43781"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:44180"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62500"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:44181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:24005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:43465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>valproyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65344"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156457"/>
            <dbReference type="ChEBI" id="CHEBI:156458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:65345"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 27">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Amino-acid degradation; L-isoleucine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 27">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="31">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.5" evidence="16"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKQ0"/>
    <dbReference type="OrthoDB" id="10262177at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003853">
        <property type="term" value="F:short-chain 2-methyl fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046395">
        <property type="term" value="P:carboxylic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01158">
        <property type="entry name" value="SCAD_SBCAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF1">
        <property type="entry name" value="SHORT_BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 27" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7 27" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 27" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="30">
        <location>
            <begin position="30"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="29">
        <location>
            <begin position="145"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="28">
        <location>
            <begin position="251"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="31">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00051903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="KAG2182424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="404" mass="44577" checksum="7941EA569A1C8161" modified="2022-01-19" version="1" fragment="single">WHSQCSLTFIRAFSSSIVANNTPTSLHTFTEEELMLKDAVSRFAQDVVKPKVLEMDETEHLDATVLKGLFEQGLMGVETEAEYDGSNCSFTSAIITIEELAKVDPSISVVCDVQNTLVGTLFRKYANEDIKQRYLPQLATNKVGCFCLSEAGSGSDAFALQTRAEDKGDHYLLNGSKMWITNSKEAEIFLVFANVDPSKGYKGITCFVVEKEWGVEIAKKESKLGIRASSTCVLNFDDIKVPKENVLGEVGKGYKYAIEILNEGRIGIAAQMIGLAQGAYDIALPYLFQRKQFGQAIGSFQGMQHQYGQIATEIEAARLLTYNAARLKEEGKPFIKEAAMAKLYSSQIAEKAASKAIEWMGGIGFTRETGVEKFFRDAKIGAIYEGTSNVQLQTIAKLVSEQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKV2</accession>
    <name>A0A8H7UKV2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKV2"/>
    <dbReference type="OrthoDB" id="10341647at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2182574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="86" mass="9722" checksum="66132B37CBF46DF5" modified="2022-01-19" version="1">MSNPTPSQPWRGRGRGGHRGRSRGRSGFRGNNMHSRGFNRGHGPPAYHTSVDEPDDGSVEYLYRRYGSLYSPNFTLDPWKALNDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UL41</accession>
    <name>A0A8H7UL41_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_006784</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UL41"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="39"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2183773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="344" mass="38542" checksum="1CA1381A12878639" modified="2022-01-19" version="1">MASTRDVEMSRVDEDRETFLPPPAQQRRSTETNYPPALVATVVAFYFIISLAVVFLNKFILSSSEYKFPYPLFVTWFQLLAALGLLVAWAYLGQYKKLFSIIPPYEFDFNIAKRVAPLTVVYVLMLAFNNLCLQYVEVTFYQVARSLSIHFSILFTYIILKKKTSTAAIGACAIVFLGFVIGSYGEINFSWEGLLYGVGSSAFVALYGIYVQKSLAIVDNNQWRLLHYNTTLAILILLPMVVLSGELTEIMNNVQFLDEFGFWLLMTVTAATGFGINIAMFLQVKYTSALTNTISGTAKACVQTMLAAVIFKNPISVTNGIGILLALFGSGYYGYIRYKERVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UL76</accession>
    <name>A0A8H7UL76_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nop domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_002295</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UL76"/>
    <dbReference type="OrthoDB" id="4771285at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000002">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000003">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027105">
        <property type="entry name" value="Prp31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="231"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="347"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="430"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2185857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="498" mass="54699" checksum="5471BB0C50ECE9B6" modified="2022-01-19" version="1">MSLADELAADLDFSDNEVEEDQDQDTTQNQQQGNDDMQTDDAVIEDEDEQRERIESMQMGNVKSVKQISKLLNSKATQDILTAIEDFKKQDRDQSRPISGPIEDDPEYRVIVQSNNLVVELDNEVLTVHKFIRDHYAPKFPELESLVLNPLDYVHAVKTIGNEMDITKVDLHSILPSATIMVVTVTGSTTNGRQLTDEEWKITNEACDMALGLDNARKTIIDYVESRMNFIAPNLSQVVGSATAAKLLGAAGGLTGLCKMPACNVQVLGKNRKTNTGFSRALIYKHGGYIYYSELCSRLPSDLRPKIQKMLAAKCVLAARIDKAHESRDGHSGRTMRDDVENKIEKLQEAKPNKNTKALPVPDEGPKKRRGGRRARKAKEALAMTELRQAQNRMVFGTAEDEAESMGSSRGLGLVGNQVGKIRASAADARSKVKAAKPTKRWGQQSSGTATSGLSTSLSFTPIQGIELADPTAAAEKVKKANERYFGTGAFLNVGKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7ULH8</accession>
    <name>A0A8H7ULH8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_002610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7ULH8"/>
    <dbReference type="OrthoDB" id="446113at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050886">
        <property type="entry name" value="RNA-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024">
        <property type="entry name" value="GEO13361P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024:SF56">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="247"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2186172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="375" mass="42290" checksum="418281635F47D4A6" modified="2022-01-19" version="1">MDRLRREKKERLQQLKKETQSTGDRKTEQPSTFDILATTMSGSASPNSSSPTGHSNAVTDTINNLPTDNTSSAATVQRLVVNSSTSHMPSPESINGDTHALNRSRSTTVGSDIIQNSRHSDKEHSDLPVASAGDFKVASDNRRMSNSEEEEVDEFGRVRTRRQHYVNRSSSNHGNDSDECDSESHHRRRRRSSSSDRGRRSTRSNRRRTSRSRSPRDRLRSRSRSGTRHRDPYTAAARYIDTEFFPTKIYIGDLVGLDKYQLEDAFSPYGQIEDIKTVAGKDFAFITYDHPESALYAIKRMDGVRLGKYRIKVNRAKIPERNRVGFGNVPWKDEDGVVAEEDNMAGRQPKQADPTQPLDPRAMGGGRQVLSYDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7ULY8</accession>
    <name>A0A8H7ULY8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_006677</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="6">
        <location>
            <begin position="600"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="827"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="7">
        <location>
            <begin position="985"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="36"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="128"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="334"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="933"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2183669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1335" mass="151153" checksum="DB5CEBFBA9D55D45" modified="2022-01-19" version="1">MGSHSRGQYDGGSSPGLSGLMQDVDSYIYELSANQPANGVADPSSHSTYPQQYRPYNSYATPSQRAPSMKYEHGNHLSPYNRHSGGSYEDVNNGYSGYQPQTHYQGNMQPPSHYPSYTQNASSAYGHNQEYYNDSTYGNQYPASASAYPPTNEAYPSQYSRYPLSDTQSESTMHMPVPTDYSYQYPPSSPTYAQGYQQTDYQPARTPPGSPSQRLSGSRPLSGQFYPPSPSQPQFRHSDQYGYNNDYSQMNSEFDRMSFEQRRPPSLPAHDSTPATTLSYTSSQHRHPLPEPPSNNLNNNLSYVPMPEVPSKVADHKTLPQPPVYSNLDHDIHRSHRAAPPSPIVTGARKAPEPPVRTYHLSNDDESSPDSPSFRVPARISSVTAQDNNYAFLSVLSKAFVVKIRALEHVRELFCAYEYPESFTGNEAVNTLKSLLPDHFTQGQCLKVAKALMHTTPQFFVPISYSEKSLIHNTIYDSPDEVYTFEDDVGDDEYPTGVYTALLPCYVRGCERGGGGCYAPRCPNRTNRGGILIVVNDTALETGDVVDAEEPRPIVHHAQNSFETGEGEAPEEEDTPHSIRAWAANVPKELLESTPKDEIGRQEAIYEFVYSEEDYNKDLNILHEFFAEPLRTSSIIESSRREAFISEVFSNYQELRQISADLYKDLRDRQRKYDKDKVPEIGDVFLKHLPDFIEPYKKYGPHFMLAEYAVQSETKKNTAFSNFIKETETRDPERTRRLPFRHFLIYPVTRMQRYPLLLGAILKKTPEDHQDHAHLTACLELIQKIAREVDELTAVSKQKLRILQVNDCISFKQGEVVDLQLTDPQRELFYEGELKRRNTSGLEMTEKQDLHVFLFDHVLLMTKARKSNADEEYRVWRRPVPLQMLFVHNNSDFGLVARASGNGGTALLGTGGAAVNAITIHHLGQRGNMYHFYANSAAEKQQWKDKIDEAKEAQRKKQGDREVFELRTLSDSTFPSTTSSSISGMGKVNCSTPFIGSDGYKRVAVGTDAGVWFGLEGDTNTFRRVLSSQSVTQLAVLEENSILLVLAEKTLTAYPVHHLLTPVNSKAPDRLAQSIAQHVAYFQIGVCNGKNLVVYMKRKNTNSVFTALEPSCGDLRDPKNAKMLTSRPGFLNRGGSTWFKHYKDFYIGADSSNVHFLKSRFNVICEKGFEIIDPENLNISRNLPDLLDPQFNFVQRLGDSLKPLAMYRIHDKFLMCYNKFAFYVDNHGALVPRGPQRTPLLCEWEGTPDSVVYFHPYIIAVEPQFIEVRNVDNGELVQIVPGEHIRLTHYGATNTYPVIHGCMNHSFRPEYQHLFQLVNHMQRTSSQNNYATMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UMB3</accession>
    <name>A0A8H7UMB3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_000946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UMB3"/>
    <dbReference type="OrthoDB" id="2407359at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2185033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="193" mass="21507" checksum="5D97F1175F1987D8" modified="2022-01-19" version="1">MSLVYGYEIDSDTAGGAGRIIVPPLLKDKITVSTSSNSNKWIFIGTRVEILHWIRGHSNVALENTIFSGGDQPSFHTHNEIVIDLLNYNDPEQSYYQYVRSYMKTDYNLDKVKVEIRPKVDSKDQNIMTTCRIIVNSGVTFGSIVDELESKWMTPGPSYVQQAVDLFSENPGPQHVLSSDVPLGVQSDGQHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UPK3</accession>
    <name>A0A8H7UPK3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002777</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UPK3"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03751">
        <property type="entry name" value="proteasome_alpha_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000007">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2186339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="255" mass="28098" checksum="B3A056A5EB480250" modified="2022-01-19" version="1">MSGIGTGYDIYSSTYSPDGRIFQIEYANKAVENSGTAIGLRVKDGVVLAVEKLVQSKLIVAGSNRRIQSADLHIGIVSAGLQADGRYLVQSARDEASSWRDNYRQPISGKSIADRLGLFVQAHTLYSSVRPLGSGTIIATYLDGEPTLHMIEPSGVYWGYRGCAVGKGKSVAKTEIEKLKLDELSVRDAVREAARMYVLKIIHTAHDEAKDKDFELEMTWICEESKGKHMLVPKEITEEAERLAKESIKSEMEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCW7</accession>
    <name>A0A8H7PCW7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_008311</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCW7"/>
    <dbReference type="OrthoDB" id="271725at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="234"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="325"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="450"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="450"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2171585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="517" mass="56588" checksum="D8E52D4D5DF54217" modified="2022-01-19" version="1">MTNPPNAAAGNDHEQNAAEKQNVKQGVDNSGRQDGSSQQRQTEHDDRNAGPPTSPAYPPFAFGYVDPVTAQYAYDQAVASGYDPSDPASFGAYIYPLSPQFSMQYYPEFMSGYQSYPGSPAMHPQSPPLNPNSPPFTPTFQFQQGGMPMSPPAHAFVLPPGQHFPPLHLSSPVLTGTNSAPGSPPHQMMQRLPGSYNNSGNRSSASGSIPRRGTQQDPQQQQLAQQQSNQFHTHNIYVRGLDAATTDDGFADMCIPYGPISSSKAIIEQKTGECKGYGFAMFENEEDAQNAIEGLNRNGLQASFARVGQESFSARLRSLQDETSANIYVSNLPPTMNEPQLEEMFKPFHTVSNRILRDPQTGLSRGVGFARMSDRAAAISVIETFNGHTLPGSNVPLQVRFADSLAQKRLKGQTARKRVWRARDFQPMAGFPARPMQMPITPETMLGFASTNNPATSQPGNPPYMTQPNFAQYPNPQQPYYNDNDQLDSTSKIDSDLSAAVENKLKIEKEEDGPKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDB6</accession>
    <name>A0A8H7PDB6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_008177</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDB6"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="214"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="615"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="552"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="598"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2171797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="725" mass="83600" checksum="AE7D33A17BA4B3D6" modified="2022-01-19" version="1">MMVHYVFCSIFRSQAEQDSAPAASEKAQPNIEHEPSDTLEFSTSTTSLSRSQTPDDDQVKNDQEFEHIINQFDDQAHDNTEHAQSDSQQLPSRRRSSTEASNRNRRPSNRSEEIAEIPFDFNKFLEQMKRRGSIPITKYFKSFLQAFDRRPWTVNEQIKIIQDFLDFIYGKMRECDVWRDASEQEFENAKEGMEKLVMNRLFHYTFSSNTTDDKERDEILNHKIRIFSWITEEHLDIPVTQHNESFLTFAESGRLNSFLTIEVFILYSSASESSELLKINNYKAPRDKLICILNCCKVIFGLIRHVEGDAGADKFLPILIYVVLKSNPPKLVSNVQYINRFRNPDHLQSEGGYYLTNLMGAIAFIESLEAKSLSVTQEEFDNNIEKTLKEIEKERPVETVREKVNYDNAIHPSQSPRPGSSQSPPPLIDPVKASAFIEKGSNFAQKTMQKPLNFMGKILQNLNDSSRPSTPDSDEEYQDYQRNTGSTEYPGRQTFSPPSQSNAGGWAQIPANWDPTAQSTQHIQDYGQYRDHVYQQRQQQQPQTYADERQWQQRQYQQHPQYDHQVYQGNATQPPMGNQWVSSPDAHIPPRRQPPPQHVQQQHVAQQQHIAQQQQYQSNLNTLLPMFSNMDRDVIEMILQANQGDLPSTIDVLLDMSEPSNLAQEETTEVQQTELPHREGPVAEDNHEQQDVPAKSEENDEHVGSTSPSNIPNKDQTEEENLIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDL1</accession>
    <name>A0A8H7PDL1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDL1"/>
    <dbReference type="OrthoDB" id="2157866at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="72"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="311"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="456" mass="51304" checksum="12D792F763C04029" modified="2022-01-19" version="1">MALPPTRQLSITLHQPTSEPARQAMSSEDDDDDEILLHNTLSNARGYTSADDLEDDEDNLPAESADLLHLEKVIKSGYLLKKGEKRRTWKRRWFVLRATKMAVYKDDKEYRLLRIIDMHDVHSTTEVKLKDKHKWVFGVVTPKRTFYLQAGSEQSLNEWMKAFQFAKEELKMLDHDDSNSSLNRDEEVAKELVSSYSSSTSPKAYSPLHSARRESQHSISSVLASSDTVTSPRTRIPPLDIPGRRIPAQDHLSTSISTNASVGSPLSPINEQAARMHLGEDAMSSEDEDYRYDESTNSTVAAVEKEGDRNRVIFEGYLLKLGRNKSWRKRWFVLRSETLAYYENEKEYAPHRILPLTDVLDSLEIDPMSKHKRHVFKVVTVKRNFILCADNMETMERWLDTLNVAVRRAKKGQHQPERPVVDNASGISGAGGVGGAGGALGGQPSSNTKPAQGVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDM0</accession>
    <name>A0A8H7PDM0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_001448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDM0"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2171972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="341" mass="39459" checksum="C9D38F04C8B403AC" modified="2022-01-19" version="1">MQNIEDAFLQCAIESAKVTWFLDLEAFRLDRQQLVNTTKGDPICRWSHSHLEALHVVELKDVSSLYPFPVDIGKVHGFWQLSTEDITAIVWNDYHRDLELNKTDDDAWKDAQNDILNSCEAHEAVKLLIMYNILYKYIVQSYGQIDTHPFVTSDMCDLDRQYFAKAVCEFFLVESRKTTMCDMIWVEDSKPLEVSYYLGALCHVKTDGMILMENDNVNQLCAWIDVKPTSHSEKDDSVLYRSGIPNKAAISLAIAQRRWCQAKGGDHTVFGVEFCGHYSAFWSTFYKHEYLHNVKNSSILPADSHSFMKRSRVFDLIESIDRKEYARHFKGMLDYIASSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDY1</accession>
    <name>A0A8H7PDY1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_008327</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the actin-binding proteins ADF family. Coactosin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDY1"/>
    <dbReference type="OrthoDB" id="20822at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11282">
        <property type="entry name" value="ADF_coactosin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000018">
        <property type="entry name" value="Coactosin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF56">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="2"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2171601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="149" mass="16583" checksum="8F2F6138CC4E3F19" modified="2022-01-19" version="1">MSLLVNDPDLAAVYDDVRDDKSETNWVFFGLASGKPDRLQVSGKGSGGLSEFVQQLQADTAGWGYVRMNMSNDEYSQRVKFVLVPWCGEAVGVMKRARLSIQISEVKNVVRSYHIEVPASHVHDLDEADILTRLRKAGGANYDRQTSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PF39</accession>
    <name>A0A8H7PF39_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_000105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MT-A70-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PF39"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045123">
        <property type="entry name" value="METTL14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107:SF0">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51592">
        <property type="entry name" value="SAM_MTA70L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="345"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2172758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="403" mass="46490" checksum="61A3A51F784E3277" modified="2022-01-19" version="1">MLASSNAVNDRSFSQVNQHQTSERCEVNESAESFNRKYPELLGDTSVRNQPQELAASHDALHNREFHNDYSQHFVDSGQRPQNYIRSTSLITRFNEYPKLQELIAAKDNLINAAAGNPWALKADLRKLDLQQLQCRFDVIIVDPPWEEYCRRSVATAFASQDIWTYSDVARLNIEAVAANPSFIWIWCGNAENVSRGRQLLVKWGYRRCEDLIWVKTNRNSKGSRIVSESEILQHSKEHCLMGIKGTVRRSTDGHFIHCNVDTDVIVSEEQPENDTRKPDELYHIIEHFCLGKRRLELFGEEHNLRPGWLTVGCDLPYSNFTSAAYKEQFLNGHLLRSTSRIEVLRPKSPPPRDPQRKQSVKKPYMSEVPLSQPPPHWPMIYPFPMPLPMPQVTMQSSMMYPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFH8</accession>
    <name>A0A8H7PFH8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NUDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_004908</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nudE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFH8"/>
    <dbReference type="OrthoDB" id="5877028at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006964">
        <property type="entry name" value="NUDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04880">
        <property type="entry name" value="NUDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDE" evidence="9">
        <location>
            <begin position="148"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="237"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="12"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="135"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="241"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2172366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="413" mass="47044" checksum="2DBF3C1955C26DCF" modified="2022-01-19" version="1">MAVDMSSRYMSFNNMQDELDYWRNHAENLENTLSETRAALDEFQVSSRELEEELEKELQSTEKVCGDLKSRCEQLKRESEDWKILMHSCDYCQSKFTESKHEHNNVMTQMQREIDVLRATEQTFRKKTLELELDNDDLERTERAAQSSLADIEMKYNKAIERNAILEQEITTKDQLAEQVQRLKDDLNGKAIDIHFGAHLYDQLSSTSHNDFFLADVNHELSVLQDKHTKLDDANQDLESKLSSSEKQNAELQNKLQQQLTRSPSSRASTPDRTSGYYEPTLSRMPTHRSRIPRTSGIPGSSNIGNASTYTGNNNPVKMVQDMVGRVRSLETRLQSCRSLVTPLLNPPPSYSSTIPIAAIGRKDTLSPGNRSISPTYNTNGRAGSPLQLANNKYRRSSINVRMSPMDTAEDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFR2</accession>
    <name>A0A8H7PFR2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xanthine phosphoribosyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFR2"/>
    <dbReference type="OrthoDB" id="9973266at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363:SF1">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2173127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25427" checksum="81CCCF7E969C331E" modified="2022-01-19" version="1" fragment="single">MVQKLHISYNQIHKNLQDAVVRHRINEDFQPDIMIAIGGGGFIPARILRTFLHKRNNKNIPIQAIGLSLYEELEQWDMENEKLKSRRTDSGSVTPTVPAAPSVTKTQWLNFGGSDSLANLVGRNILIVDEVDDTRQTLSYAVQELLRDIEKQQRESNNPAPTKLGVFVLHNKVKQKKASLPDEIMKNYFACVDMPDHWLVYPWDALDIDEHTKKADSGELIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFX2</accession>
    <name>A0A8H7PFX2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transforming growth factor beta regulator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_004593</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFX2"/>
    <dbReference type="OrthoDB" id="285793at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003889">
        <property type="entry name" value="FYrich_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003888">
        <property type="entry name" value="FYrich_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040092">
        <property type="entry name" value="TBRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22715">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR BETA REGULATED GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22715:SF0">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR BETA REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05965">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05964">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00541">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51543">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51542">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="158"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="266"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="588"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="313"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="588"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="616"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2173219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="628" mass="71357" checksum="426905869111957A" modified="2022-01-19" version="1">MLSGPSDDCAVYTASFEESDLSNMYNNSITANRSSSSSPVDKTIWEGHGLMSWILDDKSQHEPYATGKLGPSSGPYKHTVEVILQLQPSAKMSKSSFYENLSRDSRPALSNLRSPPSHNSRLAAPVPIHPSSGYSDERKHNDDQMLVRRYYEHREQPAMPLPSLSQTLPPYQPPPLPHPHEPSPYYRGGNLHDEKLDRGRNQAPPHRDDNPYYDQNDRKNLRRSPPYQSDRIPHMPSPRDRYGYNYPPPHESQQYDRLAWRDEGPWLRVSDNNNGQQHHQQQPQQQPPPPPPSQHHHPSYSFSNETSSHGHRASLQSPSSGSAASSPPNEHHHSSNDQQDSRHPRLIRASGNVPADSKAPSYPFRLPLGKTVHHTRRKKRDTKPPNANELRTIVELEKDEHGNYKLPVEVDSWTVISLGKVIWDKPAFHNQRYIYPVGYVVKKSMIDPHRDTQYICSILDGGNEPLFRLQADDNPKEVFQGQTPTSVWTIAVRRAFAVRNMEYGHNPVGPDFFGLRKNTIAKMIQDLPNADKCRNYVWQMFEIGRSKQGRGTKRPQATLADDVIHQHQFEQSVARGPIGRIRSVKLSSNDGATDANSSGSYTIVDADMQEYHRGNDDEEEDDELEAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PG38</accession>
    <name>A0A8H7PG38_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_000013</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PG38"/>
    <dbReference type="OrthoDB" id="515064at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="459"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2172666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="676" mass="75879" checksum="40C2438B38F3B960" modified="2022-01-19" version="1" fragment="single">AGLNQARPQRPFPDPTGMNDPMISTIPQLEQQRESQGSIDKAAVNRASQALNSTRPDPYKKLPITTVSNDVQDKNLQQYLHRDKMYQKSLETQHKRHMQLAHSKKAQLEMASMEKKARQQGMPVFGPGYKGFGNTRFAVQQPILYPRDKRKQKRMTHISHNMRAISAQADEEDVLVPVRIDMESNGYQLRDTFTWNLNEKILTPEKFADILCEDLHLPAAQFAEAIVTSIREQLEEYHLYAPNTHSKPSDVDASTDKVELSTGSDGDQAMVEATESTEASVAPTTTESSSASEDDLRIVIKVGILHLDGCLDITVGNISLVDQFEWSVENSSDSPEIFAEKLVNELGLGGEFRSAIAHSIREQVYVHFKSLLIGQEYGDGSYLSERVKTQLLPNLKYLLRDPLMAEKFTPVLLEISDLELDRIEREKLREFRRKRRQNRSSRRGMQLPDREALRTHRTGVAIPQTTDANEDGLGSGIENGRGGDTSWYGRKSALKARMNIAAEARMSGYRDSLSPVPTNSQLENGLPLTDGMSGFGVGRPYGNPYQGAGLRDAGRDSSGLDANGGYDAAGMDPNHMYPTPTPRNVPKPEAELPEGCKIAEDLLDWMPSKKRILESRNPHDVFDIVQLENGDYKVFCYDCPNKLYTIGPNETLKNFEVHLRNRSHRNSVEARLRAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGC4</accession>
    <name>A0A8H7PGC4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitogen-activated protein kinase-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252103at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052779">
        <property type="entry name" value="WDR62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589:SF1">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="695"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="884"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="968"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1135"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1190"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1269"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1367"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="884"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="997"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1020"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1045"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1190"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1220"/>
            <end position="1232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2173149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1494" mass="163645" checksum="65A5044CD1FAE2FA" modified="2022-01-19" version="1">MEKFPVNSGTNPPPASQSVYAPPKHITPPKLQLNPMQNNSGPHVTRRKRKEANEIPMLKLERIIGLTSSTNNMVATDPTSEQIAYAAGAVVVIYNYRRNKQVGFLYPPASVTNAVPGSNNVPAATNPVPNLPAWSLNAHPSAAEWASPSALGTDMNYGKQINDEDTGKKRTSAGTRPKTISCLAFSSDGNFLAAGEVGHQPRIFVWNVKQQSLVCVLKGHKFGIVSVAFSSNMRHLASVGFQHDGYLNVWNWRKGIKVASNRVTSRVNAMSFSKNGSHFITAGLRHIKFWNLNSTAGKQAQGQNNFQQGETQVLDGRSGLLGTLRNNNFVDVICDPDDSQISYLLSETGLLCMFKDGRILDKWVDLQVRMACSLHVCAKYVICACDNGIVRLFEPRTLRYCGMLPRPNPLGVDLSSFVNVQQLDTIKETATYPDTLAIKFDSTSNKVTCIYSDRSLIIWDVKHLQRIAIYRSFISHSECVWGTQMYPQQRTKETKINGNLPPYTFATHSADGTVRFWNIDNALPASDSTLSPTLTSPVSSSPTSYPSLVSPPLSLIASPSMKTSLPSPDQNIHRNIFSKELIKMLYLDPDAMEFAKVDKSIDMPDLPEHGIRALKISSDGKLMATGDRRGNLRVLQIVDWKEITYLEAHDSEILTIDFSTSASTRESPGLIASASRDRLIHVFDIQKDFKLLQTMDDHSSSITAVKFSMNGNTLVSCSADKSVIFRSKTPQQTVYNSYHNHSGRATVFNMELDVHDKYIAMVTGERRLNLLSLESGKLFRSCKPETTEEDAIGMTIENSGGSLIDVDLDPISGTFAVTAGSDKCVRLFDLNTGVCIYKVAAHAELVTSVKFLEGPNGIMRVVSTSSDGSIFVWRLDIEISKKMSQRAKDRTDRAKQSKPDIVVERAKPNIQPVPQLSKPLPRLRRTSAVPMAKTNDPVRAERKSFSHTSKAEAKYDDIYNKLERVSTKPYNDAPASPIPMNRARGRLSTPATRDPKSVVSSASTSRLSLMDMAGNGATSGGATDSVNQAPMRPASNSPRLRHRVSHDVLLQDRQDRKGTLPPSGETAGSVPPRQSFSNAHRTIAHRRSNSSVRLGSHDATDLLSGSGSTSMPDLHAIAEGAAGKYPAVLTAEPDSLCDSDTEKDSIDDNANDACTSVDGDDETLEEESMIFLAPFNDSTIPKPFQVEAADQDNFNDGDDNKDDDATDASAPTEESHADDSDSSSEDNSDDVLVESIAMRNPPPMSTLRKNSLKRSGRMSLRSIVQSFNSLKPVHEPAPSPTTPRSESLTGLKRKMEQAKKRLSFSTRYLSNRGPQDGISDTLRDVPSVKDLSMFIAPLENESPSGKIVRDNSFQKLILTPEELAEINSSSAHHPNSKKSPIPSETAPAQSVKQVAQDPVDHEQMLSTMTAVTDGLHLLVTACQSPEHMQTIGAEAKDHLTTSLLQSQESISAILKMLGHEQPQTVSTSSDTTALLSQYSDMLIQMVENKLNSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGV9</accession>
    <name>A0A8H7PGV9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Angiogenic factor with G patch and FHA domains 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_005179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGV9"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053027">
        <property type="entry name" value="AGGF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106:SF24">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="169"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="3">
        <location>
            <begin position="383"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2173759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="51105" checksum="E8E184D732002CB7" modified="2022-01-19" version="1">MPDQHDPYRDSIDQYLALSTTDEKKTSYHHAGHEHSYSPSDTVNSEYANAHHVSWKAHNTESSYERRSPSQYTTSPTVFQPRLVNFVATADPQYLYNYQTNLYYDVLSDTYSRLDEARMIYETVLEKDAAEAQAYFSNEPSSDETLRMVVLESQLLPVNNIVLVDANGITIGRDRSWDRRLRLPEMAVSKYHCHIFSTSADIFNETNEAEEACKIEATKFSIIDVGSQNGTFVNSNRLSASKAASPPTPLRHMDVVSVGTTKFQVHDHQGSWPCEQCKHKDGNTIDIAATTQAKTASEASDNAMHHSKYDREQARRDELKRLKQKYHDEKPVRTSGKYVDRADVRRKQQGSDHTALPRQQDSDMSITPVHSSQPMHVNKRLGEENIGNRLLQKMGWKEGQGLGSSGSGMVDPIQAEYRQGRAGLGATPPVEEPYGTKGRSLQLTRKRYDEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGY7</accession>
    <name>A0A8H7PGY7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGY7"/>
    <dbReference type="OrthoDB" id="10432469at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="197" mass="22707" checksum="1C492876D7BEE6CB" modified="2022-01-19" version="1">MESDEEESEYQLDESSEEEELGEQLEIPSDEDSDGSMNHLQGYPDESEETSEKELKKSKAPKEVTFYTKLSAQTAQGGAYRRYFIHREHMISKAAKMRAEIIREHQLQGPSEELLRSIYMLTAHRCFEVENVPDQDLFRQSALFAMGVLVEEMAKHAANKEVDMESHEQDNSMAGDNHDKDTRNSRKRKTGSKTRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PI43</accession>
    <name>A0A8H7PI43_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_004440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PI43"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2174417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="150" mass="17121" checksum="9026B3B5CD7694A4" modified="2022-01-19" version="1" fragment="single">MAQDLGLHRSATNWNIPKAEIELRRRLWYATYVMDRWVSAELGRPVTILDHDFDVDMPSLYDEIDSSPSVGCSIGTPKENSIYPADHDGKVKQVYHTFIHVIKLTQILGQVLQGLHSPRARSLGRRNESLICFLDGALVRWKLNLPPELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIF3</accession>
    <name>A0A8H7PIF3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Mitochondrial chaperone BCS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_004174</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIF3"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="14">
        <location>
            <begin position="63"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="274"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="489"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="499"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2174154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="57968" checksum="E7CA9A8EC1DD3CA3" modified="2022-01-19" version="1">MHPRQALLTSQLGLVVKNANTLSRSYSSVPDAVGSQDTVGGIVSNIAQHLGMGEFATGGLQLAVIGGFLAGFRYFGGYFVDYVKKRVIVTANFDSRDESYSWILNWLNEHPYSNVATQFSVSTVISRGAQRLPGEGLDSTAPAVYFLPAHGLHILRHKNRFMWLNRERPSPSVAAAGGQSNGPAERISISTFGRSRAPLHNLVLEARTLFIERDKSRTVVFAADQYGAWRRTRSRLKRPLSTIVISHTVKDRLVNDAKEFLESENFYAERGLPYRRGYLLYGQPGSGKSSMIHSLAGELGLNIYVVNLSNKSLTDDTLGELVSDTPSRCLLLIEDVDSAFVQRTQGSANSSVTFSGLLNAIDGVAAQEGRILCMTTNHIERLDPALIRPGRIDVRILFENASQAQAAELFRKFYPGLPTQDALKLSKEFSSHIPEKRFSMAHLQGYLMGQKNNPIAGANGIQEWVQRHENNGGSDSTAYDQDQEVEEFGNTGCISGTSTPVRPATPARPATPKRIPFTLPEVRKPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJ56</accession>
    <name>A0A8H7PJ56_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_005793</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJ56"/>
    <dbReference type="OrthoDB" id="2996783at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009668">
        <property type="entry name" value="PRK13189.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF4">
        <property type="entry name" value="PEROXIREDOXIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="4"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="7">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2174735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="218" mass="24359" checksum="4E1D5EFDF24262FE" modified="2022-01-19" version="1">MPSIRLGTTAPDFEAQTTKGPIKFHDFIGDNWVVLFSHPADFTPVCTTELGLVAALQDEFDARGVKVIGLSANELESHEKWIADINEVNNVDLKFPIIADPKREISALYDMLDYQDITNVDAKGIPFTVRSVFIIDPKKTVRLILTYPASTGRNFDEILRVVDSLQLGDQHRITTPGNWKKGDDVIVHPSVSTEEAQKIFPKGVKVLKPYLRLTPSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PK09</accession>
    <name>A0A8H7PK09_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycerol uptake protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_005981</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PK09"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2174919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="69147" checksum="2FBD1C3538374992" modified="2022-01-19" version="1">MSAPVSSGQPNSDSKSPSKWVLQPSRWRTNEFYFYYFAFAMVVPYMFKVTYDLSKGKVTKPFNLTCEIYILDLHNLGADIVAVLEDSPHYSDDENLIIHLQLIHKLMNNPILQDNSDNQYASFRDNIPTLVPLSLTYLALSHLYQRYCCCVTPIKHSNQSLSRTYFILGAAFLYIAVTNGTSIFKVLFITTVSYTIGMLTKGSWLNPALTWGFNLAVLFANEWNDGYRYSQLGESFAFLDNYKGITPRWHILFNFVMLRLVSFNMDYYWKHKQPREAYDKDERMGGPINDKDRIQKPCFAEDYNYINFLAYVLYTPLYLCGPIITFNDFVSQLRYPSTNVTRRYVTQYAVRLVFVVLTMELTLHYLYVVAISKSRAWAGDTPLQLSMIGYFNLVIIWMKLLIPWRFFRLWALADGFWVEENMVRCMSNNYSAQMFWKSWHRSFNRWTIRYIYVPLGGSKYFAFNMWVVFTFVALWHDIQLNLLAWGWLICLFLLPEIVATTVFSAKKWGSWPYYRHLCALGAVGNILMMMIANLVGFCVGLDGMMDLLSQIFTTVDGLIFLLCTIVCLFIAVQIMFEIRESEKRRGDPKWVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PK54</accession>
    <name>A0A8H7PK54_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_001174</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PK54"/>
    <dbReference type="OrthoDB" id="2357462at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050490">
        <property type="entry name" value="Bact_solute-bd_prot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43649">
        <property type="entry name" value="ARABINOSE-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43649:SF33">
        <property type="entry name" value="POLYGALACTURONAN_RHAMNOGALACTURONAN-BINDING PROTEIN YTCQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="634"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2175527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="701" mass="78499" checksum="B67C6BA5787B6B00" modified="2022-01-19" version="1">MILSCFIHVSHSQEAQTNSTDDTYMTIDQSLPLGNAQILSYNDKDELLFSVNASNLKDLNTYTQPELSDVAYFVVGEGPIQLELWSPFGENGNSVVAPALLLAVNDWVVLSRNTSTTTGGSMATLNGNDTVTVKVVVGDFNSDWMAYCGENGVKCPDMVILGTTQIALHAAHGTIKPLDDLFTEYTEKQNSLLVDSFLKYTFYDYQWNEHWWAVPLLTDVRLTYYNRTTLRALNIKPPPPEGDWGIQWWDNWNWTVFLENAQKVKDSGIGYGLEFVGQYDEETKLMNMISRDWQVDFFKTDETSCGLQNDAFNGILDNIVRPLWAPINSHHGIANPLKLTSNASSFLSWLKTPIDQVQPTKVDPAGFCCDYDLWPTDFLAGYRIDTPANFNYTSVWIKDWAINSTNLWDNSTEIGVGLAPGVCSVCLASGYSNSNADVVLGGSGLAISSTTEYEDLAWDFIQMVINPLISDTSGANYEYLNVLNEANGIFPPYETTEQLPPWTAPSFYTARTQIAHAVPMQYPHSTSPSVSSIEDNHVFRQMIFNMAFKNATNEQAISQTCNLLQWLMAPDCSYEYWTITKPDICNSNTGTLEVTFSWTNSTPVCQNGVTMPSTYSIPCSYVDITTSQGTAITVLNSFCAVVSILYMILLAIYRNTQSIALRDNRLDSRPWILAFIRSFVCDDMAFTENLPYEEQDTTPNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKR6</accession>
    <name>A0A8H7PKR6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Nuclear proteasome inhibitor UBLCP1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_001368</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 17">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 17">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKR6"/>
    <dbReference type="OrthoDB" id="1711508at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090364">
        <property type="term" value="P:regulation of proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011943">
        <property type="entry name" value="HAD-SF_hydro_IIID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051658">
        <property type="entry name" value="UBLCP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02245">
        <property type="entry name" value="HAD_IIID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="13">
        <location>
            <begin position="67"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="14">
        <location>
            <begin position="192"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2175721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="378" mass="43126" checksum="B0BA803C43EF8BEC" modified="2022-01-19" version="1">MAADSSLCVDSTTSSSITIDMPQHAATDSNMASVLTPTNENNKRALQPDTEEESGDQSQSKKRPLTFVASWQKKTYTMTCTPEETVQQLKKKLQDLTNVRPQNMKLLNLVKGKLPADDTRLDSLSLRRKPGSDAIEFLMLGTADEKIFKDPDQVDTLPDVFNDLEYDYFPSDHPTHLDQAKVQRKLKDTIAKTNIRLINPLRQDYTLFDCKSPASHISELMRPGMHSFLTSAYEHYDIVIWSQTSWRTLEAKVTELGILSHPDYKIAFVMDITTMISVTTLKADGSEFKHQVKPLEIIWAKFPQFSSKNTIHVDDLSRNFALNPKAGLKISAFKHAPVKRLTDRELYYVARYLLLIVDVDDFTTLNHKRWRSYHGVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKZ9</accession>
    <name>A0A8H7PKZ9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKZ9"/>
    <dbReference type="OrthoDB" id="5331396at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849:SF1">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2175660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="142" mass="15838" checksum="6D62261ACD89351F" modified="2022-01-19" version="1">MNIILKQTARTGYAGAYNIPRNMTRSYSTHSPKVTGAVRGGLLGFLLGVTISGGIGYYYLLEEYNEASASLLQSVKDLQDSTDKVRDYARKIEAIDRDLAKLKDSAATSQQLTDLRHEFKKLYDGLNIEHLELKTHVWGLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PL15</accession>
    <name>A0A8H7PL15_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Vesicular-fusion protein SEC18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_001297</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PL15"/>
    <dbReference type="OrthoDB" id="9982946at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000115">
        <property type="entry name" value="N-ethylmaleimide-sensitive fusion protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000166">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000012">
        <property type="entry name" value="Vesicle-fusing ATPase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000187">
        <property type="entry name" value="Vesicular-fusion ATPase SEC18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="287"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="573"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2175650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="793" mass="88313" checksum="7ED65A53A6B5545D" modified="2022-01-19" version="1">MSDPYRSRSPYGSTPPSRGPPSYKSAPPQAMQHGVMKVGQCPNPEAALSNYLFVAPGQFDPHEHYLIVNDSYVFTLVADDTVPPGFIGTNLMHRRWGQFSLKQDVQVRPYDPFEGGHDIYLSSVQLEVGYLRKGTQVDGELSAQEMAEVFTNSFKNQIFSHGQLIAFEFQGTTLVCRVTALEVVELSALKKNFTGEIDAKHDEYQRFAQRGVLMQQTSIDFVKDPESPIRIKDSNRLAKAKPLIRPDFKFEDLGIGGLDSEFSAIFRRAFASRIFPPAIIEKLGIQHVKGIVLYGPPGTGKTLMARQIGKMLNAKEPKIVSGPEILSKMVGESEQNVRKLFADAEKEYKEKGEESGLHIIIFDEIDAICKQRGSRNDGTGVGDSVVNQLLAKMDGVEQLNNILIIGMTNRLDMLDDALLRPGRLEVHMEVGLPDAFGRQQIWKIHTSKMRESKILDPEVSIELLTELSANYTGAEIAGVVKAASSYALNRHIKVGTAAGVAPNVNEMTIQLEDFKAALDEVPPAFGISEDELQQCVQNHLLRFDERVQYCPYQKILEDGKLYVEQVEHSTRTQVVSLLIHGAANTGKTALAATIAMDSNFPFVKLISPEAMIGFNESGKINQINKIFNDAYKSPLSVIVLDNIERLVDWVGLGPRFSNTVLQALLVLVKRKPPKNRRLLIIATTSQRQMLEAMGLDSAFDDEIEAPLITRVDTIGFVLQQLDLFNDSEREMALYQLHQSNVDRNFEIGIKKLLMVAEVASQSKESKVAKFVESIKSCMIARPNYHAQTKALEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PL49</accession>
    <name>A0A8H7PL49_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_001106</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PL49"/>
    <dbReference type="OrthoDB" id="49520at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029525">
        <property type="entry name" value="INO80C/Ies6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="6">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2175459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="136" mass="14985" checksum="58212430984C1A54" modified="2022-01-19" version="1" fragment="single">TASTASSVQNSVSRSVTPQSVDSTGTSLLNLLQQPRPFKNKKYAAPKKARSLKQLLTQEKQPDFNVDIPTYQNIESPPSVRPLKKYCDITGLDARYTDPKTGLRYHNAEIFQFIKGLGVSSVQAYLGSRNAAVVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLB8</accession>
    <name>A0A8H7PLB8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_005380</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLB8"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="634"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="686"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="713"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="9">
        <location>
            <begin position="8"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="10">
        <location>
            <begin position="141"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="8">
        <location>
            <begin position="432"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2176147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1033" mass="119289" checksum="8FF2F17BE14C1FB2" modified="2022-01-19" version="1">MHYHRNPAPALSPRLFSFLDALFLPNSYYLKNTGLDSALYLQFLMMCIHFLTLACLLVLPILLPLHWLSDITPFDMHSTTTLSHLNVSNVPDGSLWLWAHCILTYFVSVTWIWLLYTNYWRYLDLFRVQMALRTVKGDVTARTVMVQNVPHELRNDSSLKGYFASLGVGEVETVNIVRTAGKLERKLKRRQLIIDRVERACVRLGRNVIHRLEKRRGRTGVGKVDVSRALVFQDSLPRDESLLSYLDKVVITTKQAEDAVMDSSQQASTVSNAQSSVTLPSTPVSIIPVSNEYNLWTILLLNAPPQSLLQYQPTHSQSFTISLPGIDKHNMIPSKLKPERVVSIPKYLESLTALTGRIEELRDSDASGRYYRPTSTAFVTFVSWKSAQLCAQGLTCWKPNVLETKMAPEPRDILWTNLMRRGRRGKIIGKLRDWLVFGAVWSLTIFWLFPISFILGLTSLEALSQHFEFLDTFKETSSVIRSFIQNVLPTMLVTLFMSMLPWILCLLSKQQGFKSYSDLEDCVLRRYYHFAIFNVLIVFLLGTTFLTTILNVLYTPTSIIQLLAESLPQGANFFLNFILFNSCTHAMELAQLGTQLFGRLLALIPFVSPTPRIFVRKSIPWSFPYYYYYPNHILIFVIVLTYSVIQPLILLFGLMYFTVALVVFKHQFAYAYIRRYEANGLYYRRMVRYTTDGLLIFQLTMVGLLYLKKAFPCATLVTPLVLFTAWVKLYFHRRFQSRCKYLAIDVDEYDEVKAMEETGDEKGWRYLFKRMDDMWKISWFAVWWNGARGKWEKTKERSTRKVQQLLSPKLDNNSIIDQEMPYPTEPIAAAFAPKVSGSAPPAARHSTSLPIQNQQIDQYHVGRQDYFSTSSLYANDEISQHQSYTHPIFHSKIVDSFMLPRDPSKRLWRPVDCIDINIDKIVKQYYDDILGDLEGGNYSVEQKMESQYTYGDSREDLHNSYDTVVVHRVDTTRTNDSEKSPVVKRRSRKSIPRGFNFRNSHCSDDLAVEIELQEGMNQLYELETEEVSSGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLS5</accession>
    <name>A0A8H7PLS5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Heat shock protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_001208</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLS5"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140453">
        <property type="term" value="C:protein aggregate center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000134">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000021">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="609"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2175561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="647" mass="70629" checksum="E8F5E0491396BDC7" modified="2022-01-19" version="1">MTKAIGIDLGTTYSCVGVWQNDRVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPHNTVFDAKRLIGRRFNDAEVQSDMKHWPFKVIDVDGKPKVQVEHKGEKKTFTPEEISSMILVKMREVSEAYLGGKVDSAVITVPAYFNDSQRQATKDSGLIAGLNVLRIINEPTAAAIAYGLDKQPKGERNVLIFDLGGGTFDVSLLTIEDGIFEVKATAGDTHLGGEDFDNRLVSHFVQEFKRKHKKDISDNPRALRRLRTACERAKRTLSASTQTSLEIDSLYEGVDFYTSLTRARFEELCQDLFRSTMEPVEKVLRDAKIDKAAVHDIVLVGGSTRIPKIQKLVSDFFNGKEPNKSINPDEAVAYGAAVQAAILTGDTSEKTQDLLLLDVAPLSLGIETAGGVMTPLIKRNTTVPTKKSEIFSTYADNQPGVLIQVFEGERARTKDNNILGKFELSGIPPAPRGIPQIEVTFDMDANGILNVSANDKTTGKSSKITITNDKGRLSKEDIERMVSEAEKYKAEDEEVAARISAKNGLESYAYNLRNTLQDENVGGKLEEADKNKLKEATDEAIKWLDDSQEASKDEYESRQKELEEVANPIMMKLYGQGGAAGGAPGGMPGGGFPGGGGAPPDDNAGPTVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PM11</accession>
    <name>A0A8H7PM11_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_001328</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 9 (cellulase E) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PM11"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001701">
        <property type="entry name" value="Glyco_hydro_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22298">
        <property type="entry name" value="ENDO-1,4-BETA-GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00759">
        <property type="entry name" value="Glyco_hydro_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034898441" description="cellulase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 9" evidence="11">
        <location>
            <begin position="85"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2175681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="651" mass="71796" checksum="924A4B501342D92D" modified="2022-01-19" version="1">MVNFFALKLAVAGLVATNFVDALPERRVASTGKLMKRKSGSSLTGSEAPPLDKPVAGDPIISQTGAPAPRTSPYYQAPHPPFANYYEGIHKAYLWYEAQRSGPIPTQRLAWRSDSCKVCKADNGADLSGAWYEAANTMKWGLPLAWTVTQLAYNVIWYKDILSQGNELNQALTTVKWGTDYLINAHINDTTFVGQLGISGIGDNDDIDFAYYLAPETFEQRMPEQYWHPVLYCTPATPCGDIVAESAAALAAGSIIFREYNSTYADLCLSHAESMYSYAKQYPASYNIANNSGNANSSWYAAAGWYPSSSVADDISLAAALLYMNTNQSTYLNDSITYYNSNDGQNAWSEESWDSQGGHLHVLLYNLTKDATYLTNFKAFAGQYLPGPTQSFNQTPLGLAFPEYWGTIALDMNACMDMVTMAKIIGYQDPYSIEMFNFCTQQVNYVFGEKGYSFMVGMNNTYPLRLNHISSYNPYDDSPLYNQTLETIENDFLSGLTDNRRIAYGAIVSGPDTQDHYQDDHQLYQYSEATQDSSAGIIGLLAGLIDWYGQDNFKAFSDCSLDLGWSHPNASAKPNWPSDDCYHTCNTANCNYAVTLFQSNNKQMVNQTSSNSSASSSGAKSSQSSTSEASHHILPVLYITVATCIVSLFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMC7</accession>
    <name>A0A8H7PMC7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_005614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMC7"/>
    <dbReference type="OrthoDB" id="406186at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2176380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="175" mass="20135" checksum="A5B3DE2F7812EFFB" modified="2022-01-19" version="1">MTIFSEDLNTLSRLFAANKEPATQVDFNTFLEELKQYGVHNPAIPNELESLWKIASEWHLIADHYNVFGFNIYGPKTVLQTTKNVFGEEEIRQDWASDHGEDSCGGADWLCLAGYTEFDYIFMNFNSQSKLFGATRHMVNNCNDDREFTNAPFVEFVKHIKANIEKYKEDAEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PND1</accession>
    <name>A0A8H7PND1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_007652</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PND1"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000039">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF44">
        <property type="entry name" value="THREONINE--TRNA LIGASE, CHLOROPLASTIC_MITOCHONDRIAL 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="87"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2176998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="477" mass="54838" checksum="0EFBE2C8B90750DD" modified="2022-01-19" version="1">MLQTIRYQHMLSALARVSSVSRQHFPKRALVIGTTRQWNSAFQARRFQSTIAEVKETKHIDRDLDPSDHRYIGKAQSLFMTHPYSPGSVFMLPHGTRIVHKLQEYLRSEYNRYGYQEVMTPLIYKKGLWETSGHWQNYMDDMYMVHGGQASNEEEGLFGLKPMNCPGHCLIFDSTPKSYRDLPIRLADFSPLHRNEASGALSGLTRVRRFHQDDAHIFCTEEQILPEISSCLSFVERVYTAFQFPQYDFTLSTRPKEGYIGSLQEWDNAESALRKALDATGKTWTIKEGDGAFYGPKIDIMIRDSGGRSHQTATIQLDFQLPRRFNLRYSDENDQIQTPVIVHRAILGSIERMMAILIEHTGGKWPFWLSPRQGVVIPVATQFMDYAQEVANILACGDAEKPNMANYYVDADTSPRDRLNKMIRRAQLNQYNYIFVVGQKELDERTVNVRTRKGQVLGTMSLEAVRDLFAQATVNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNE9</accession>
    <name>A0A8H7PNE9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein sorting 55</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_005605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNE9"/>
    <dbReference type="OrthoDB" id="14246at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034424">
        <property type="term" value="C:Vps55/Vps68 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2176371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="15429" checksum="E67E552C60C21B76" modified="2022-01-19" version="1" fragment="single">LDCTEIKHLLLLVHNDITSIIALAFVLAVGFLLVILSCALYHNWWPLFVVATYVLAPVPNALCARCAGGDDLMSDYHSGVVDAGEFITGIFIVTGFCLPLVLAHSEVVSITIPAMIMSIIGGILVYGTIIAYTHFFANEGEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNH1</accession>
    <name>A0A8H7PNH1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM4</name>
        <name evidence="12" type="ORF">INT43_007885</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNH1"/>
    <dbReference type="OrthoDB" id="747253at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120115">
        <property type="term" value="C:Lsm2-8 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01723">
        <property type="entry name" value="LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000005">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034101">
        <property type="entry name" value="Lsm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="80"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2177228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="128" mass="14293" checksum="6FDBB6B751A7CDC4" modified="2022-01-19" version="1">MLPLSLLHTASGHPMLVELKNGETFNGHLVNCDNWMNLTLREVIQTSPDGDRFWRLPECYIRGNTIKYLNVPEEIIDMVKEDENKQRQNNRGNRGGRGNQGDRRDRGGRGGRGGGQGYSRGGGRGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPQ7</accession>
    <name>A0A8H7PPQ7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPQ7"/>
    <dbReference type="OrthoDB" id="10291997at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="81" mass="8653" checksum="A30151D95E96053B" modified="2022-01-19" version="1">MPATKASVAVASTLTKSPRKSDNRSHSSKRGLLAGAVNGPIDRNSGSIPNMSSGSVVTRNYCLMHNLFFLTSWCPKCRTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQ39</accession>
    <name>A0A8H7PQ39_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RhoGAP-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQ39"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="312"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="445"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="771"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="55"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="619"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="696"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1028"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="709"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="740"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2178212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1050" mass="117172" checksum="AA9BB9CEC43F358C" modified="2022-01-19" version="1">MSAPSAQEVGELEYLKSQNAQLWKVITKQKSVIHRLQKENSKLAAERDELTQKLVSRANQEKSEISVEADESKTDQILPEASSPSQGRQAKDTQSPTTTTGPTVPPRSPYRQNSTKEEARTAAQAFNSAPSSPSSPIKVVPPVERKVAPDPLILCNSPPSPVPGVMSPSKAIMDKDAQLFAEFNATLFKRERQDSPVNLINATFPRDYQQESELQRQQALKGVSTIGIESSQPLATNESKQDEVTVKTPIESVISPSIPTEQPSEPPNPDVPLETPVAAVARATKTETEETTLQTKHMENETGDMSHDAFASLSVRVIGSKIKSNERDKEVLCFIISVGRIPQAQRGTAHADEHYEELWRVEKRYSDFIALDNKMRAGALNEMVKHTVKFPEKSLFSTVTPYKVDQRTVALEKYLQQLIATTLDRVSDISEFLSTDVIQEENNTMGYKEGYLTKRGKNFGGWKKRYFVIEDHVLNYYDMKNGNLLGLIQLRNSKIGRQAQQTPTDTKDNRVFRHAFLILESKKPASNILSRHILCAQSDVERDEWIDALVHHVNIPEEEVSTGSNNPSVLSKLRKLKKADKRHKPSSDFTSNYDSIPTSRKTFEISGTEDARFADLPFGIKQHRSNSDPAVTPFIRSGSREHLPFRPPPSKLYANQDSGFEADDQQQNATAPGKRGSLNMSRPTREDMIEHQIWNIEEPQDPTIDEKMSSSPSPNSSPSPGSSNAKSISSRVANWRRKTLSPEDIREGVRPTTPNAEEPLEPPPNPLQFGISLANAVEATRATIPCELPAVVYRCIEYLDANNAVLEEGIYRQSGSTSVINELRQRFDKDGDYNIVNSNVYYDVHAVAGVLKLWLRELPTLVLTAELHEAFLCVMDLLDPEDRLKELGRLVSILPVVNYTLLRALSAHILQVVQNSAVNKMTLLNVGIVFALTLGIPGSMLNMLLTEYEYIFLTEDEVSTSSEQANDSAVDSDQEDVTEREVLEEPIPRFLTILKRGDDKRSNRNSMMFLSGAPNAIKHIEKSLDTKQSTLLSDDEELSDSVSMSGSEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQA0</accession>
    <name>A0A8H7PQA0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">PIN domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_003359</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the XPG/RAD2 endonuclease family. GEN subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQA0"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048256">
        <property type="term" value="F:flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000030">
        <property type="entry name" value="Flap endonuclease GEN-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="15">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="14">
        <location>
            <begin position="867"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="285"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="637"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1096"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="639"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1105"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1123"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1136"/>
            <end position="1154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2178106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1154" mass="130863" checksum="14AA20A3FB89243B" modified="2022-01-19" version="1">MGVKNLWEILTPVARPVQLDSLRQRKLAIDASIWLYHFLKAVRDKEGNALKNAHIVGFFRRICKLLFYNIRPVFVFDGGAPALKRLTIEKTQLKFKAIGEAEKRVQNSIASGDVNDVLAGNYTYLDELQAAAAKSKKFRKDPYELPEDEGAIAKAKKEMDPRFATDEELRDFIMEFKPSDLDVNSDMFKMLPTELQYEIIQDLKLKSRQTSWARLDEMIRKSRTSLDFSKQQIQHLVHRNVMTQRLFDVNSTVGNEAKSQPVRIASERGRQYVLVKNEDLKAGLGWKLPGSKDAGTEDQPILEEDLENHEIESDESDDEEPKDKVFAALQNNAALQRLLKSVGSGDADNEPEDNDREELTDASELFVQNRADQEASLQDTGLRSDVLDNMDAYVDDEMTVEEVMAQFQGKQELDEKLKQQHENPYKKPTPTPRSPPKPVIDDLSGPELTEYWIGHAPDAFIYEHSLNDEYKSMIHDAVYNVSVEDLEANLTSTKKKLDKVPSHDEIRKESLMFYKMLLEQTLAWKQLQVKRLETFHNDEKASAQNDSANPIMTWDDSDDDFEALDYSLLEEPAEDPSTIKLSVETQNISNASERASTSDDALSDTFFSTEHSFLKANSNDKVSAVGEVPSFQELKAVETSPSQDADTQSRSPSSDDVLEDLEEKKLVPELVESSDEEAWQTVTVDQAEKYTPIVMSNTPDTSLSFTADMEEDEPIESLVPMSDQIKASPMTSIPDGHSKPPNSAEIDIPPSVTFDEEPSFLEIKEEPVPVPINDVDPSIAGTDEVKLADITQDQEGYDSDAELGTNLDAEDKEYARFISEFGSKDFAAARQEANEDLIALAKDQRKQKRDMDELTTQMIEDAQELLRLFGIPYIVSPMEAEAQCAELIGLSLVDGVVTDDSDVFLFGASKVYKNVFNQEKYVECYVSNDILQELSLGRERLIQLAYLLGSDYTTGFAGVGQVAAMEILKEFQDDVDEDDPLGPLKRFKEWWETPVAPKDEKSDFRKRFRKRHSGMEIPEDFPNPHVREAYLSPHVDPSTQEFQWGMPDLDGLRKFLYSMLGWNEKKVDDLVIPVIKEMNSRKATAQASIGRFFDISTDKPISQPTRKRTYKSKRMQNVVQSLRQRDSEAKEKQTNKRSTSGDVESNNQRSTKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQS7</accession>
    <name>A0A8H7PQS7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003318</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQS7"/>
    <dbReference type="OrthoDB" id="416496at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050508">
        <property type="entry name" value="Methyltransf_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912:SF83">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 12" evidence="3">
        <location>
            <begin position="127"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2178065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="306" mass="34864" checksum="F948478AEF8715B3" modified="2022-01-19" version="1">MAKPKRPIRPTYQAKPSNVNPPAHVAKTASRSTPKVIPLVIGGALLYFGATYTTMLVYKSKQDTQKDIERIESNEEVTTINPENFDTTTIWNKIAGDYDKEISTDEFWMGIGLLRRWLIGKARGDVLEVSAGTCRNGKYYKPDQVTSLMFTDKSEAMLDQAQSKFSEYKDKFKNAFISFQQASIQEVGQLKGQKFDTVIDTFGLCSCDDPVEALVSLANACKDNEDSRILLLEHGKSHYDWLNNLLDKNADKHVTKWGCWWNRDFMTIFNDERVTKELDIEQVSRWHLGTTYYVVAKRKSASKTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PR52</accession>
    <name>A0A8H7PR52_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PR52"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF4">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="110"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="274" mass="32028" checksum="9C4BED3314508D52" modified="2022-01-19" version="1">MDTARQKITDRNALFKEHSETINSLRNALLRELTSIVQEFSLNEQRAAAVAAYMNDRVTLFRFLLRNDFSLPTALSLLLKNIRWRLKNEVDTLTYRTLPSELFDSPFVFFHKQDKLQRPVLVINVQYLPKYDSSVFVEKLRPFMILIMEMARKLTRDITMVREERGEELPLVQDLVIVVNLANAGRVPMDKQFGQMLIDYVSNKYPAMVGSVIVLNFGWMYQGIWQMIKLILTENAKQKISFPKPAELANLIDREDILQGKAHMFFLFRCLFVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSB3</accession>
    <name>A0A8H7PSB3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Metaxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_001706</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSB3"/>
    <dbReference type="OrthoDB" id="198787at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="7">
        <location>
            <begin position="63"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="8">
        <location>
            <begin position="206"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2178860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="33368" checksum="BA654125B177F1B1" modified="2022-01-19" version="1">MSRPQLPALPTIELPAFLEPLKLKGFPLKTYPATLEPERPTKPQLYVFGPGWESKNTSFDVDCLAMQIYLKFCSIDFDIVQSNEPYASPKGKLPFLVVPPDHCLYGEQIHHWLQKHEKQKKLENTEQESEAQAFITMIEKKLGAALLFTLWLEPLNASKLTSDKYFGDVARPIDKLLAYRKKEEVVQSLLIDRDVLIREEIYQAAAETLSALSVKLGTNEHFFGSNLDRHPTLVDAFAFAYFHIILALPQITDSEISKEERQQATALRNLLLNHSNLTQYTKKMYSTWLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSH0</accession>
    <name>A0A8H7PSH0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_001902</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSH0"/>
    <dbReference type="OrthoDB" id="2260257at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034789788" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="35"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2179053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="219" mass="21599" checksum="333247E894DD0BB6" modified="2022-01-19" version="1">MHALGLLTLLSSALLIAAQTATGPSEKDPIFITNPVESSDIKSGKSLNIKWSSIEQAPETVNIELLENLILHSRIAEGVDTSAHGYQWDVPDDLASSNNYAIRIGNGAYLSYSHMFAIKGKGPLIAAPSAGSPTTGAPMTTASASLGSASGSASGSASGSAPAQLSMAPLSNSVLPSAAPSASMEGSVSSAGSSSGSAKLSAVGAFGALAGVAAVAANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSH7</accession>
    <name>A0A8H7PSH7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_001812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSH7"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2178965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="114" mass="13120" checksum="AF56754AABE8F514" modified="2022-01-19" version="1">MPGSTNFVDANSVSKNSAHAINDRINLCSPAAYLVRMWRDYENTRLVRWHLVDTTCSNLSKKNSGNDFERVLDKLIRQSALKVLTSVASTGQFRRRHFVTEQRIENRKSCCEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PT79</accession>
    <name>A0A8H7PT79_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Meiotic recombination protein DMC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_001662</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecA family. DMC1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PT79"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19514">
        <property type="entry name" value="DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000239">
        <property type="entry name" value="Meiotic recombination protein DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000032">
        <property type="entry name" value="meiotic recombination protein DMC1/LIM15 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011940">
        <property type="entry name" value="Dmc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02238">
        <property type="entry name" value="recomb_DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF30">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN DMC1_LIM15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="11">
        <location>
            <begin position="114"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="12">
        <location>
            <begin position="294"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2178816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="38913" checksum="1B9B6E7F65839E5D" modified="2022-01-19" version="1">MPSRRASPPINASPPAEKEEILEKEADQDENTEEEIFYEEVDQLQAHGINVSDINKLKCAGVCTVRGVQMVTKRNLCKIKGLSEAKVDKIKEAAGKIVNCSFVTAMDISFARQKVITISTGSKQLDSLLGGGIQSMSITEAFGEYRTGKTQLAHTLCVRVQLPLNMGGANGKAAYIDTEGTFRPDRIRSIAQGCKVDDDIALENIIVARAYNSDHQMELITELAARFAEEKGAYKLLVVDSIIALFRCDFSGRGELAERQQKLGVMLNRLVKVSEEFNVAVFVTNQMCADPGAGLTFVADPKKPVGGHILAHASATRLYLRKGRGEERVAKVYDSPDVPESEASYAISNIGITDISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTV9</accession>
    <name>A0A8H7PTV9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3 6">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_003911</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3 6"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTV9"/>
    <dbReference type="OrthoDB" id="425211at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000003">
        <property type="entry name" value="3-methyl-2-oxobutanoate hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001452">
        <property type="entry name" value="PRK00311.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="332"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2180123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="365" mass="39917" checksum="0769F33CCCE05974" modified="2022-01-19" version="1">MAQRLLISTSTVFKSALAINYHAPIRTTWHARLATPTQRLYSSRPQEKPSDTFKRPKVTIRTMRRMAKQKEPITMMTAQDYPSGLMVDRAGIDSCLVGDSLAMVALGLDSTNPITVDEMLHHCRAVARGCKAPFLIGDLPFGSYESSPDDAVKVALRFVKEGNVEAVKLEGGKEMAETIRRITTVGVPVVAHVGLTPQRQAALGGFKVQAKTAKQARALLEDAIAVQDAGAFAVVLEAVPEEIATYITEQLEIPTIGIGAGKGCSGQVLVQNDALGVFDRFIPKFTKQYAKLGQMMVEGLREYHEEVKAGLFPTQQNTYPINEAELTRFFESEEQRQSQNQSNQSSENHNENLKAAPTAAVKASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUJ6</accession>
    <name>A0A8H7PUJ6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_003802</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUJ6"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF111">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034810442" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="23"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="522"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="591"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2180015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="630" mass="70849" checksum="EFDA08D420312D85" modified="2022-01-19" version="1">MAHHGWLSCLLALFLLVNASVAFYLPGVAPHNYKKGDQVPLYVNSLTPIVSSNSQLKSVISYDYYYDPFHFCQPEGGPEKQSESLGSILFGDRIFNSPFQINMMEDVECKLLCTTSINKEDAEFMAERVKENYAINWLIDGLPAARQRTDERGEENKQTFYGIGFELGYMQGTNAHINNHYHIEIMYHTREEDNYRVVGVLVFPQSINNQLASGQLSCSGNGNGGQEFKYDGKDTITYTYRVAWKESTTPWATRWDNYLHIFDPSIHWFSLVNSIVIVLFLTGMVAMILLRALHKDISRYNAVDAQEDVQEDYGWKLVHGDVFRPPTRSMFLAVLVGNGAQLVAMAGVTLVFAVLGFLSPSNRGSLATVMVILFMVFGSIAGFVSARVYKMNGGEAWKVNVALTAVLFPGVILGELFGLNFFLIASHSSGAVPFGSMIAVLALWCLISLPLSVIGSYFGFRKPRIEHPVRTNQIPRQIPDQPFYLRTVPSVMMGGLLPFGAIFIELYFIMNSIWFHRIYYGLGFLFLVYSVLILTCAEITILMCYFHLCNEDYHWSWRAFFTSGASGLYVFLYSALYYFTKLDIGSFTGTVLYFGYSAIISVLVTVMTGAVGYVSTLIFLQRIFASIKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUS8</accession>
    <name>A0A8H7PUS8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1,4-alpha-glucan-branching enzyme</fullName>
            <ecNumber evidence="4">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glycogen-branching enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_003923</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Glycogen-branching enzyme participates in the glycogen biosynthetic process along with glycogenin and glycogen synthase. Generates alpha-1,6-glucosidic branches from alpha-1,4-linked glucose chains, to increase solubility of the glycogen polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUS8"/>
    <dbReference type="OrthoDB" id="196493at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000001">
        <property type="entry name" value="1,4-alpha-glucan branching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000250">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000003">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="12">
        <location>
            <begin position="192"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2180135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="715" mass="82466" checksum="2B5BC5BABDBB0864" modified="2022-01-19" version="1">MSQSVPVFQEEVEPGRFLTMPEDGSGVVVLDPWLEPYKDALVKRYSNYKSWVKKINESAQGYEHFTRGYDYFGFNVQPDNSIIYREWAPNATSASLIGEFNNWNHDANPMQKDDFGVFHVTLPPNADGTPAIPHNSKVKISMSIPQSNERIDRLPAWITRVTQDLNVSPIYDAVFWNPPQKYVFKNPRPPKPASLRVYEAHVGISSQEPRVGTYKEFTANVLPRIAHLGYNTIQLMAIMEHAYYASFGYQVTSFFAASSRYGTPEDLMELIDTAHGMGITVLLDIVHSHACKNVLDGLNEFDGTDHCYFHEGGRGRHELWDSRLFNYGAFEPLRFLMSNLRFWMDKYQFDGFRFDGVTSMLYKHHGLSYGFSGGYHEYFNEGVDDEAVAYLMLANDFLKKTYPNVITIAEDVSGMPSLCRPVREGGIGFDYRLAMAIPDKWIKMLKEQEDHDWKMGDMVYVLTNRRHLEKNIAYAESHDQALVGDKTIAFWMMDKEMYTNMSDLTPLTPVVDRGIALHKMIRFITHSLGGEGYLNFEGNEFGHPEWLDFPRDGNNASFHYARRQWNVVDDKLLRYKYLNEWDRAMQIAESHYHWLSAPQAYVSRKHEGDKIIAFERAGVLFIFNFHPTQSFSDYGIGTHNPGEYRVILDSDDKKFLGHGRIDHSTSFFTTPGEYDGCGQHMKVYVPSRTVIALRRKDEITWTQDDMEVPYQYNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PV61</accession>
    <name>A0A8H7PV61_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_008477</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PV61"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="59"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="61"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="367"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2180897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="406" mass="45668" checksum="EB71D8564ECDD833" modified="2022-01-19" version="1">MAANENRKSISSLLNPPSYDQNGSDSSLKAPTSAASRRYSAPPRSSFATEQDANPDDQPAKKAKRKRITPEQLVDLLALFEKTDTPSFEVREKLANQLNMTNREVQVWFQNRRAKVNRARLNAMSAETAQSQHRFQHSPLTPGINGSNPKYQFVPTFSRLDDHQQQQQPPQIHTPMDYHSAGSVATRRTSAYPDMESARNRTGHTMDEGHSTGSKHLSIPPPIKVSQQDHTMKDSDHRHSTPLYSPTSDMFNLSLNPSSQQHKSNYFDQRRHSGSMSAPQTPTHQGQYPPTLATPPGINPHPVSSTSSPYHRRSHSNSYSLPPTPAYSDHSAIDLLASAAEYVQKSEEKRKRRASEQMVLPSLTRAELRSVRSKSGSDIWGSVTEEVEEEEKQDERPKPKSFRPWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVK8</accession>
    <name>A0A8H7PVK8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVK8"/>
    <dbReference type="OrthoDB" id="2287961at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034215048" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2181409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="18935" checksum="DC6D3364EA4829C8" modified="2022-01-19" version="1">MKITAATSIAFFAFVAAAQAQNTCDCDPSDYSCLKDCGTYLTMTLPNICIQDCSDDSCYQNCIQDNWPGQTGSSSASSTDMASSTDASTATDSSMMATGTSSSDMSMMTGASSAIATASSAYLSASASLNSMLTSGLASASSSFLSAASSAASSASQPSASASSTSAATTVQAKGAMLAMAMVAAAAVYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PW66</accession>
    <name>A0A8H7PW66_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_008567</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PW66"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="10">
        <location>
            <begin position="174"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="322"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2180985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="769" mass="88274" checksum="978B28B444AF7822" modified="2022-01-19" version="1">MPAVYSEEPGTGTVDYKSLTNINDIKECLRNLDAEENAIDARLDRILDDKTRLEETIYQLSSMKPKLTKLKSDGSRMVTIISGTSSLAERVSEKVRKLDLEQSRVKEAIRQVEEVQELKQCITSMQDAMLRRDYDEAATLLHQSFNVDHSILEGSFAEYTVPTSENPDNPTKTISDIKAALFDIFSQRFDSAVSNRDQKEITRYFKLFPLIGCYTEGLERYSNFVCGLVRNQGSESLRMNKVPNTSFYADAITALFENVALIINQHQPMVKAHYGPGSMLRVIQRLQEETDTQSLRILERYAQDRKIDRRVSEIRTVGLSQLRSPTLTRANTSNNPASSSSSPSLQPHEPSVANPLLDPRELDSSSSELAIMSRHSVLFHRFLASRAKEELQAISDPDEFWKDSNRKSYDSNGLLTVSRLSKRVSDLLESYLIMEEYLLRRSVNMAMTIDEYDESAGETSSCVDDVFFILKKVTNRCISTASVDTITSTINLIIKIMESDYIGHFQRKMSTAFSGHETNKSKSIEIARTAYMIVLNNLDVSSVYIQRLSEEAMENVDKNLLEDESYQRLQKALQQLVDMSEKMKKKLNSGLEQFFGQTVKPRIRPLFQEAYRDVKYVLDEEEYDEAESNDAFVRRFTQGFTKLIESYRRILTESNFTYMLGLTVDSVAKQWEKIVLQTRFNQLGSLRFDKDLRSLTYYLSNLTDWSTRDKMTRLNHIATILNFEEPSEIFEFWGSKAGPNTWRLTVTEIKKLMALRIDLDHDEIANLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXG0</accession>
    <name>A0A8H7PXG0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXG0"/>
    <dbReference type="OrthoDB" id="10405221at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2182058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="72" mass="7866" checksum="5DE4BF68B69D2D76" modified="2022-01-19" version="1">MDVATPHPPAVPSTDLQAHLDSIETHILNVKKSLETPDMAIGSSAIQLRRLLHLLDSSATEIRELTHPAARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXU5</accession>
    <name>A0A8H7PXU5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Imidazoleglycerol-phosphate dehydratase</fullName>
            <ecNumber evidence="4 9">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_007038</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="4 9"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXU5"/>
    <dbReference type="OrthoDB" id="447729at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000004">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000001">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="entry name" value="Imidazole glycerol phosphate dehydratase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002111">
        <property type="entry name" value="PRK00951.2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002114">
        <property type="entry name" value="PRK00951.2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133:SF2">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2182111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="203" mass="21835" checksum="B56A80B8147EC36D" modified="2022-01-19" version="1">MSSNSEQAARSASIDRKTNETDISVKVNLDSKMNQEIDVGTGIGFLDHMYHALAKHSGWSLTLKCTGDLHIDDHHTAEDTAIALGMAFKQALGTPKGIKRFGHAYCPLDEALSRAVVDISGRPFASIDLGLKREKIGDLSCEMIPHVLFSFATAAGITLHVDVLKGNNDHHRSESAFKALAVAIRQATELTGTNDVPSTKGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PY70</accession>
    <name>A0A8H7PY70_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_007363</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PY70"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00238">
        <property type="entry name" value="ERp29c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02998">
        <property type="entry name" value="PDI_a_ERp38"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1150.12:FF:000001">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000032">
        <property type="entry name" value="Protein disulfide-isomerase A6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF11">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034851954" description="protein disulfide-isomerase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="76"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="213"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2182433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="450" mass="49685" checksum="618D4B009B486C63" modified="2022-01-19" version="1">MGVFRSLFLFLTLLNVAFLGYDFYQGGHLANDLVTNVQTLTPEKIQGHVLTAVDNIKTLTPQQVASQVNVLFDHLKNVNSPADLFKFKSGGAAGLVEMEGNVFVLTDDNFKSVIDGSKPALVEFYAPWCGHCKTLAPIYAQLGDAFAHAQDQVIVAKFDADSNRNTGSEYGIQGFPTLKWFPKGVSSPEGVEDYKSGRDLESLSKFIKEKTGIRPRVKAVKSDVVVLDTKNFHEIVDHSDKNVLVEFYAQWCGHCKNLAPIYDKVGNAFANENNCVVAKIDADTERDIGTEYDISGFPTIKFFPKGSNKEPIAYEGARTEAGFIEFLNKHCGTHRVVGGGLDDSAARVPELDELAIKFVSTSDKIAQEGILKKAEVEAKKSEEKLASYYTKIMEKVLEKGHAFLNTEKQRIEKIASKGSMTESKADNFKSRMNILAAFDKNAKPVSKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYV2</accession>
    <name>A0A8H7PYV2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_007340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probably involved in the biogenesis of the COX complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYV2"/>
    <dbReference type="OrthoDB" id="10040024at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF2">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2182410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="289" mass="33390" checksum="2638F2255061B9DC" modified="2022-01-19" version="1">MQSFFRPSVRYRPLLKQTWNLQPLKAPSGVRYLSTDAEEIYKPRRRLGLGTLALCTIPFITFGLGTWQVQRLRWKTHLIEDMEERMAKSPIPLPKRVNAQAVKDFEYRRVRVSGVYDHTKEMLLGPRTRGDGNSGYFLITPLRRENGSIVLVKRGWVPTEKKEQSTRPESLDEGVQEIEGLLRGTEMKNSFTPDNEIENNQWFWVDVDTMSELTGAEPVVIERVSDKPASQENELIRRGIPVGRSPVVEVRNSHLQYIITWYSLSAATTAMLWILLKRPAARPNKMRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZ48</accession>
    <name>A0A8H7PZ48_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_007373</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZ48"/>
    <dbReference type="OrthoDB" id="269804at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000003">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018298">
        <property type="entry name" value="Adrenodoxin_Fe-S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00814">
        <property type="entry name" value="ADX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="10" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="17">
        <location>
            <begin position="503"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2182443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="639" mass="71951" checksum="AF5C353D2B2B4BB8" modified="2022-01-19" version="1">MPCWHRGCKGCNSRNLNFDTQISSLTHKPLNGYSEPLSFVSQLSTMLGRCSNALRLISTKPVLSQVRPNTIYAARRIPTTVPATSFSTFGALRHGKEGVSRGDGPYTVHFITPEGEKIDVKATEGDSMLDLAQRYDIDLECACEGSLACSTCHVICDEDYYNRMEEPTDEENDMLDLAFGLTDTSVYFAHFAFTSMTEKAPDYQDHVMDDNIDIDENEAIKDKQPKGNANDGRKLIVVLENASLEASQVHPYKLDKIQLLNCDDHQALLKRLNRDIAEARPDIVHQCLLTLMDSPLNKSGHLQVYIHTAKDVLIRINPECRIPRTFKSDLTFSFSASSVQLLQKQSIVSMTGADKLLEVVPGPINRYLPENSKKLAMSWDAPKVRLYPYFKQIPQEQPICVAIGAMAKGQDDFADTYVDEKIGVSDYALSASVACGKVCCALEDLWEIIVKIHDLTSENIPFDLRLPLNLFLDTLYYRLFGIGRNYADSAREGRDNQVYDENDVRQVAGCIPIDTASNRVLLITSSKHEGVWVLPKGGWENDETQAQAAARETWEEAGVRGNITRHIGTFVETTKKGNVKANHWIYEMYITEILKKWPEKKKRERRWFTLDEALLVTESKPYMQEALRQSSLATGVRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZ68</accession>
    <name>A0A8H7PZ68_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_006425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZ68"/>
    <dbReference type="OrthoDB" id="2249524at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="113"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="977"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="237"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="394"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="870"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="989"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1052"/>
            <end position="1068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2183419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1091" mass="124019" checksum="CCFDDFD35B229BB2" modified="2022-01-19" version="1">MYNGYLATPNSQRSSIAPEYTRRAPSPGGSSVSSKDASDRPNSRMLTRRPVSGQSIASIQQQHHLLAAQPHNSPPALHRTPSNSALSIQSGSTSRLEDDDTMSEMTTSSLESKVAKEGWILKKNSLMQWKSYYGVAKHGNAIKPGSLSLYKDEKLISHHQTFDMSEVVEVEPRAQQYYQNIKYEFRMLVKREDTVFATEDPQERKDWVAALTAIMGKVSLASQSELKNRVSNAENMTRGLQSVASELEIECSELQRQLQDQEEEFMIREQKLREQWLIKEKGLKRDLEDSQRAFKTRTELLERELSIWKGKCTDLEKRGEMTMMKKTSESQFKLQQAEDEAKKWKTKATDLEATNELLLRQYHRAESLVAQSKVEGLRMDGKLSFEQAAIKDAVNEMRLDLSKLTNQMRNSESESQPLDRKLGEVQAEVTKIGGAIMDSKKEYEELNSRLDKLISDESESTKLNNSESTKLLKNVHKQIEELKTELIGEQSDEEKIDSAVDVSTTNSSISRKFDTLMQLVETLHGKKVKTDSDRSKEMANVLESIQKAAEREMLMVEDVQKATEKVYEDISNKYDSLSLLVTQNQEKTAQTLSYIELALKDAKDNHNTIKADDLDKIYRKVRDSQAQISDVLAGGLQKMEDSESKRAHEQEKSLSVLSQLFQHVANQIDNSAIPDLPDYVRQMDEMLDRLSETELRLTEIAQAGSMQSMSVAPRDKTGVIAPIPSSQSNEIVQMLHNTRSFMERTLRVLDKFGGSSHGFEQMIKTIIKQSLPATETYNIAKKSNDMSPILDEKLKRYEDNARSYLDKSMDGMRNHLEDYTGVMYKMIEDLVLRAMEHLGNNREKESFSNYSAKDTKSINTDQLDTLIEMQTKLAANKQVLEADIKRLTEEKKTLSLDVRQLQKEMKDLQEQLMEGKAEFYSLQKSTDHINQTLARFDNIGPLLKQLSKLQLMSESSSRYDHDSEGDSHSSEEYVNVERDQIALPKPNKTRSVSPTPSQHSGPEASSWMQRKAAYHTPPPIVPNGMPQRTPNYESALPSREPSMASKSMNRNSRYEATELPESPKERSRLNMPFNNLAGRRRGSSPSRPSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZA0</accession>
    <name>A0A8H7PZA0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">microtubule-severing ATPase</fullName>
            <ecNumber evidence="8">5.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_007106</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.</text>
            <dbReference type="EC" id="5.6.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZA0"/>
    <dbReference type="OrthoDB" id="10251136at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008568">
        <property type="term" value="F:microtubule severing ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd19509">
        <property type="entry name" value="RecA-like_VPS4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000022">
        <property type="entry name" value="Fidgetin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000093">
        <property type="entry name" value="Fidgetin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF86">
        <property type="entry name" value="SPASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="201"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2182179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="442" mass="48496" checksum="73C7A28D01A30A0A" modified="2022-01-19" version="1">MSTSRANVSPALKKQRLYHDRAYAHVKNALDLDDSGRLEAALASYQQGEKALKEAIDLVFTPDEWVSAKATEQKMGKNLLQVEQRIAELKEIVNKTAQSPKSNDKSRTGITKAILSSDIAVKSPPQQPMEKKRKIETNAKAKYLKNVDPKLANAILDEILVNGAPVTWDDVVGLTFAKQALREIVILPTLRPELFTGLRAPTKGVLLFGPPGTGKTLLAKAVAHESKATFFAISASSLTSKFVGESEKLVRALFATARELQPSVIFIDEIDSILTERKDTEHEASRRLKTEFLMQFDGVAGNADSKVLVLGATNKPQELDQAALRRFAKRIYIPLPSPEARLGLLNHLLKGQAASISDKEANEIISWTEGYSASDMKELAKDAALGPLRELGDDVLHVGAEAVRPINYRDFVAAQATVRASVSRQSLAAYERWNEQYGKTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZH8</accession>
    <name>A0A8H7PZH8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_006132</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZH8"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="53"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2183137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="492" mass="54254" checksum="6E1D40EAA5B4E078" modified="2022-01-19" version="1">MSDVSQESNLDVEKQDVAHLEGVKAQPTAADPNYKAKISKAEKKLLRKIDMRILPYLCAVGFFQFLDKMTLSYSSVLGIIQDTHLQGAEYGALGSIFYVGYLAMQVPNSFMMQRIPLAKLVGGIVFLWGGVIALTALGSNFQQLAGLRFLLGFLEACVNPNFILLTNTFYRKQEVASRIGAWWLVNGLCTAFGGLIGYGIGHMEGVAGLHAWQWIMIILGIVTSILGVVVFFFLLDDPRSPRFNFTEEEKMIMEERLRDNGIKRSNEVKWDQVKECFRDPKTYVWFFLAVLINMTNGALTTFSSLITVGLGFSGLNSILLQIPSGFMDAILILLGNWIHGRTGDTLYTCAGLMFVSELGLIFLAVLPGSVKLLGLYLVYGYAAAYVLFMSSIASNTNGYTKKIWTNAIVLVGYTVGNIIGPLIMTSNQAPEYIGGLVGCIGASFVAILLMIGVRFYMGRINKRKAVGTPKGQMGHSEEDITDVLDPNYVYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZN4</accession>
    <name>A0A8H7PZN4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_006393</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZN4"/>
    <dbReference type="OrthoDB" id="360521at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027079">
        <property type="entry name" value="Tfb1/GTF2H1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013876">
        <property type="entry name" value="TFIIH_BTF_p62_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12856">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08567">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BSD" evidence="8">
        <location>
            <begin position="151"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="BSD" evidence="8">
        <location>
            <begin position="235"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="106"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="206"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2183387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="578" mass="65524" checksum="5A1387E1DFC2BCF0" modified="2022-01-19" version="1">MWEPDEQLVLRSNTKYKKKEGTLFATSRRVAWQQSGSRQLHPAVRYGDIQVQMQSPATDKNIRLKIVTNAPESKSYVFHFESARAIAEREAIKTYISESMARARQQAGDKTAAPVPVATTTDSPTSSVASTPAPSTPIIQPSSNAPTPGPASQNVNLSRQEEIASRLQLLSKSKELHTLHSELVINSKNVTEEEFWDSPYVQKIRQQMKKDAASKEGQQKGKSSKMVELRPGQQEGSDVKYTLTSQIIHDIFAQYPSVKRAYDANVPDKMSEQNFWKRFLASEFFHRSRTGNRSTNAASDDVFDKCLREEDAENLNAPSLAEFDHFKKTIDLSATAEDHNESGNAPDFTMRPGSQNLPLIRRFNRHAMRVLEVPSKRRKQESESEQNDITSEIIISDLMEEEPPARTVLDIQDTRRYFESQSRSQDSHLLTNGNAPSIFQAFKENFDHFEPNLTTHLMTPTAAANVTSSLTAIIKHKNRNSSMELDLKLPPQMQQRLMDYHSTTNEILRHFWSSFSPYKAEKNKRMVDSLKRQREKINEVLISANSFKVNLESIKQASPVMKAVDTALKAAAKRPQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZR8</accession>
    <name>A0A8H7PZR8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MICOS complex subunit MIC10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_006745</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Mitochondrion inner membrane</location>
            <topology evidence="2 9">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the MICOS complex subunit Mic10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZR8"/>
    <dbReference type="OrthoDB" id="1916310at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007512">
        <property type="entry name" value="Mic10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304:SF0">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04418">
        <property type="entry name" value="DUF543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2183734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="87" mass="9423" checksum="0C83D62E4BB716E2" modified="2022-01-19" version="1">MSSKPRIASEDILAQKWDQTVSNFVVKTGLGFSVGIVASALLFKKRTWPIAIATGWGFGVAYADAQKLFHPAYVPGVTIEKQKPSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q120</accession>
    <name>A0A8H7Q120_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BUB1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q120"/>
    <dbReference type="OrthoDB" id="248495at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="2">
        <location>
            <begin position="118"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2184439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="591" mass="66885" checksum="AE7FDF819F1F8DBC" modified="2022-01-19" version="1">MAKAEGNILLPKCGGPTMLLLQPHPETRDSSRAKCRAPASEPTMPGDPNAPNYPMTDAERQQLIASIPEFSAFESHKENILQKKQGRSAAELTSLFAMTDHERTAYLDEQRARFRQVLELELDELDDPLEPYVSYVACLEKCQTQGPTRELVDILEEATRRFDDDLMYRSDIRYLVFWTKFARLAQDWQSIFKYLVDKQIGQTHARFYEDYAQIQEENGRYDDALATYRKGIAQGARPLLRLQRHFEEAKVRIQQKRGQDQTSALPRAILGEKATLATARRDSPARDEIRMASPRREKFAVFSDTASPVKIIASSPSSSSKPIQQTLPLDVYRRKENTMEKSVFKGSTIKQTGNKPAPAKFAVFRDDADSNKDEAPNHTLVQHTVTPRNTIATAGKYSFAYYMGANNVSEALPNSSARFIEWFESVKTSIIRSEDSRGKPEWVAATRSNDNENASEMSFEEMRALYPQYKLNMAPTTSFSTEDFEEKPITPDSPTIETKAAMRIVGEIWTTAGPDFNHIEDMDIDSRPKQSASRNMTDENGDARPMLPHTPTRRPLSIVSTDVLSTSLSSYRGDARELGSPSKRRHLDTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2Q0</accession>
    <name>A0A8H7Q2Q0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_000649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2Q0"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14016">
        <property type="entry name" value="STKc_CK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="51"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="382"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="510"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="609"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="388"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="611"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="623"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="641"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="677"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="725"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2184736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="739" mass="83754" checksum="0B99D37BD05DE259" modified="2022-01-19" version="1">MTTVDSNFKQSLESPTYAKSSYHAPHYTSSVESARTALSAGSNEVLVGEQWLVLGRIGEGSFGEVFEARDIDTNRAYAVKREPKGMRHPQLKHESIMYDALVGGPGIPACHWYGEHEDFNCIVIDLLGPSLKMLRQAVSDISLDIALNVACQLINTMEHIHKRGIIYRDVKPDNFLFPANFHLPDPDCYETQTDNGFMVYETAHPSCKALFEEQDQSALKLHAIDFGLASWWRNPSTNKPYPEGKRRIRNKTGTARYASLNVHRGREHARRDDMESVGYLLIDLALGSLPWTGIQARNSRLGWDKMREAKSIIMLQDLCAGLPMAFLRYIEYTRALKFEDEPDYAYLRSLFEGATDAGPYSEIVLSFDKSYQRDPEVQVLSTVSDQSTFRKEEQQDNKYYQDRASTEKDHDKAVPHASRENDGIFTMDDIPNEAEKPHHMNREKSEKQGNGQKNGRQRSRELSNTSLSGHKRYFKQSREKRPNVGWNTHRRLQQPWEPKIDWETIPSAEKTSASWGEDRPNGMWSKASTENRPDWAAKDPINESWALKNNGWGDSNLWDGGQQINVNDNKISNGQNLQNATSVQSWFPGANFSEPEVLEMTSDMAFVTLNQKKDGSTSDKAKAGKRGRHPTSKPGQHRRRSNDDKRSGYPEKGGNDNQKHGKSQTSPRRNGVWVSGGSATTMKNNGDNIIPDINQQHEWQRIGSTKSDRKPFKPKSYKQTGGYGRNTQQKGSNTIHPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2R6</accession>
    <name>A0A8H7Q2R6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">IMP-specific 5'-nucleotidase 1</fullName>
            <ecNumber evidence="12">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_000374</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = inosine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27718"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="3.1.3.99"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ISN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="12"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2R6"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006190">
        <property type="term" value="P:inosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071590">
        <property type="term" value="P:nicotinamide riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071592">
        <property type="term" value="P:nicotinic acid riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009453">
        <property type="entry name" value="ISN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213:SF1">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06437">
        <property type="entry name" value="ISN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028836">
        <property type="entry name" value="ISN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2184465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="419" mass="47031" checksum="2717B6AB4985F100" modified="2022-01-19" version="1">MTSSYRINYQLRSHKRDALIEFIKGTMQTSFVLYDEAEIELPETSQDRGALVRSKERYAEIMSGVEKLINVRDHIEMQKQGSPEHSRLHRLVPTVSQFFTPLPLRKAFLLADAQHTISARHFVPPSFNDIRRILNTAQVCAIAPTLNLVTFDGDMTLYDDGKDFQRDSALVALIIKLLSFNLNVAVVTAAGYTENAEARYEGRLSGLLEGFAMSSLTNAQLARFHVLGGECNFLFQLGEDYHLHFVPEEAYQPESVRTWSQNSEQINAILDIAQANIQKCIDDMGLSAMVIRKAKAVGLVPQPGVTILREILDEVVLSTQHHLLRYQRSPSVLQAALPFCCFNGGSDVWVDIGNKLIGVQMLQAYLNAKPEETLHVGDQFLSTGNDYATRSSCCTLWIINPQETQEALVQLTDILEKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2Z4</accession>
    <name>A0A8H7Q2Z4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2Z4"/>
    <dbReference type="OrthoDB" id="1060854at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF94">
        <property type="entry name" value="PHO85 CYCLIN-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="366" mass="41117" checksum="6784B85FE6B2EBCE" modified="2022-01-19" version="1">MSDAHFDLASFPASETIKMLTKILVKITRTNDRLCSASDEDMSRRPHEQSAMYTCFHARSIPTIDIHSYLSRILKYTPCSNEVFLSLLVYFDRMSRNDSNLRIDSFNIHRLIIAGVTVASKFFSDVFFTNCRYAKVGGLPSAELNTLELEFLHLNNFNLSVSIEELQQYGDQLLNHCLREEKLKRQAKPGSPSISHTSKTISSQPRKIEEVPPDINSQQSSNETENGSGDKKRLSKSNTISPNESEGSSRPPNISNNTDTSPKWANGRYNNSMRVPLMVDTKSSRLNSNENDSRTPYHRLSGSKFQQSTPNFSSPSRKLDALLDASFSSNERKLPSDTDHYLPTPPNSVSPQFQAHQSAIADSISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3D0</accession>
    <name>A0A8H7Q3D0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_000469</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3D0"/>
    <dbReference type="OrthoDB" id="10261918at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="9">
        <location>
            <begin position="102"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="19"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2184560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="378" mass="44228" checksum="590B2F0E7EA28997" modified="2022-01-19" version="1">MDFLQSTLKDEIEKKRKALQAAKSNDTAAANKKYISRAELERLREKEYLEEQERERKKKEEQQAAKDKSRHKELANREKKDSPAPKNDTADDESNDTDTYNISQDEVVRRLRARGQPIRLFAETDKSRKARLRTLELMEERSEGQRNDFMVTLEQMDAGMNLEALKRKAAGEDETSKPVKKAREDALIEPVQMEWLQKQPEKLYPTIYGYFKVRYCRNFMVSPNVHIINHIFQKTLREWEVAMEERPEEVKRSGQGKRAAAMQMQTATYLKPLFKQLKSKSMEPDILARVTEITYHMQNRRYRDAQDSYLQLSIGNSPWPIGVTMVGIHERSAREKIHAAQVAHVLNDETSRKWIQSLKRLMTFAQSKYPPDSMSQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3V1</accession>
    <name>A0A8H7Q3V1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_000726</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036121">
        <property type="term" value="F:double-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061749">
        <property type="term" value="F:forked DNA-dependent helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032042">
        <property type="term" value="P:mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18799">
        <property type="entry name" value="SF2_C_EcoAI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="429"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="696"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="7">
        <location>
            <begin position="884"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="1291"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="1533"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1893"/>
            <end position="1917"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="134"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1893"/>
            <end position="1907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2184813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1917" mass="217290" checksum="F98AEC06846DB862" modified="2022-01-19" version="1">MYTIHHPQPVQLPSNAYTSRESFYSKPARANDKNTSSFFENHIQVAPLHNGHSAQRAMSPVHYSAHSELNIVGVEDIYRDSPVFREYLSDHETSLAKFGVFTDAISEVYEAGKLFEKSVQILALAVSDLLGDKYNEDEEKCETLLSKLARMVENFDQHHHLASEKLSDQLHEMKNRKKKADDLIEKLAPAMTACREECEKCLEHSSLMSDGNDMNSIKGYQEEALALFSSKEKLCKNAKEDSNKRRRFPGSLLKSNEKPINEDVSQISTIINLVHNFQDGTATFLNEVSQNIAEMRPMPVKQNLSDSLGPQNYTGVEQSDVPIALLAQLQNNLLEEFEVQDHRLHKHLSSYYEELRALCFEKMYGRSHTNHQYPGNDKHGRQMHPYIDVLNDTTMSTSPPPSTPRSPLPNQIFNQPEPPLLDPSVINGGTNMRGYMYKKSIKNDISIWRRRYFYLIASEARLMQYEDDQDDTAVANIRFCTISVVPLVEDKENVVSIISADQKEILLKPETENELYEWMQALTAYQDIRPQDSKSTSPMVSRQKPMEFNQFSLSAISLDPSETLTSTSACRTSYCPGPGIDGEILKHGKVHLRVENKKDKNFSIKNSYWRKLHCSFKSNGKFELFDGHEHRQVDTVTIPNLNRNQIYPVENSVFSTFGCFAIRTSPIRAIYLSVATRQELESWLTLLKIFAQPNVSGYRSGNTPDIDSFLYRLERTLCIRVFEAKNISLGSRESSCELCCEIAVEDEVLAKTGMQKKTPLPLWNEDFTLSNLPEIAQGLTVTLVSKSKHKKESRIGKVSLSVSELHNDRLAGEWYRLQKEHRQGAFATLAGLGAQALDPTGSLRLGTMLQERIILPVYSYEPLIDILTNFDNHVTIELAQKAPNLESFVSNALNIYEGLGLAIPWIYSLIDYEVSGITAGNSLLTKAIDLYMRMISRNFLEQTIGETIRALIDSKLHIEVDPTKTPKGTNISENWKQLFLYVRSLWRGIELGKSKCPMELRSIFAYLQASIVKKFVLDDEEENNRQTIRYNCVSGFIFLRLICPAILSPRTFGLVRDQPDVKTTRSLTLLAKCLMSLANLVDPSLKEPWMSFLHQFIMENTKSLMEFINFVSITPFTEDELYNDKGGYIKTAFAKITKPFRGDKLPQTTLEDIPIPPHYIDLPKELSRMTSAITNWSSAGMEGANNSATIHQICCMLDERFPSLISYNFMFFLQTIAKRYTIPICPSNKSVSSVLFRKGTLQLHRVCLATSNATIKATIVKNDNVSSKVLREYQQECVNASLEQLQNGKRRQIVSLPVGMELHIVNRSGKTVVMANLLAKIPDRSDIATKTLVLAHREELLDQAQRQISSINPKLRVVVDQGRRKPDIGTADVVVASVPTLGRTGSERLERYDPNLFKAILIDEAHHAAARTYQNILDHFGATDHDSKMFVWGCSATVRRHDGIGLQGVFDHIVYHRDFLTMVEEGWLCNMRVTTVQTKVDLSSVGTRFNDFKEKELSKAINTDDRNEIIVKSWQKYAGRLESIRSGNEAIAYETMQFSEIDGRKSTLVFAVDMAHTLSLCNAFRAIGVKAQFITSKSSNIERHEALESFRDGSCPVLVNCGILTEGTDIPRIDCILMARPTKSSTLFQQMFGRGMRLHESKKDCLIIDFVDNFHRAGRSGIVTIPTLLGLDISTELKGKPRKDIDLLEVERQAEGQVSKVDKSSFLVDQHASSEADIHRPTAHLTITEYDSIFEVVDDCSGTKDLHRISHNAWVSVGDNVYILSIKGGSIKLEKDNDDLWHAKLRRIIPTSKSKPIYTKPKDLPLTADSRDQAIKAMDTYLNNYYKADSTNSLWIKRNARYRQEPATEAQIRVLKKRFGMTVSDGTITKGQAMNLFARMQEGQGRIWRRQAESRKKKISEHEERVKAGVLRRNNTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4K9</accession>
    <name>A0A8H7Q4K9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_000852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4K9"/>
    <dbReference type="OrthoDB" id="2277683at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2184939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="46967" checksum="9768ACD7E76F9971" modified="2022-01-19" version="1">MSPVTNLVLQPSTSVVDLFSEQGALNATSHELAGTISFNLSCRMAIRAIYVKWKGTSTSVHQRNPERLRMTDTRSTFVLCKEKISVLTTPTTLDAGDHTYNWTLSFSCDNLPPSIDLPQHNISYTVSAQVIADGYLRRPSVRAVVPITINRHSLGAIHLASYIPNIRYRGQRADKLRYEFELPKMACMQLRRFDFAGKLVPFMEGCQANKVTVRLDQIETYSINHPNMLDKRASKQYSSDGIISHVSQIGRKCTHLSTYTPLDKNNVAEVTSPALNSLNSIWLFYLLLDTEFNIEDTMSLTQHLSLYLPLTSPLISPTLKSQALNISHRIRLRLYFEDEKEMALSFPLVISTAPVQDALASPPSSPISLTEEGWLRGLITDSEVGMPPAPLDQLPSYDDVLSEGLPPLVFTETLNAPIYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4W1</accession>
    <name>A0A8H7Q4W1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_002299</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4W1"/>
    <dbReference type="OrthoDB" id="18574at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090422">
        <property type="term" value="F:thiamine pyrophosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000011">
        <property type="entry name" value="Mitochondrial thiamine pyrophosphate carrier 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="10"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="120"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="220"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2185861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="343" mass="37962" checksum="D5385EB860B573B2" modified="2022-01-19" version="1">MPSHVTSSELTPSQTALCGSVAGLVARFVIAPFDVVKIRLQLQSQRQHLPYLQKGVQGSVKYTGFVNALKVISAEEGIRGLYKGNLSAEYLYLTYGAVQFYAYHQAENMIAAMDKNRTIPAPAQAFFCGMTAGTIATAATYPFDLLRTRFAMQGEQKVYTGVVQAIREITHNEGVRGLYWGLGPSITQIMPYMGLVFMSYDMLSSGFSWMRANHTLSESHRGLHDLTCGALAGILSKWGVFPLDVVRRRLQVQGRHRTDYVIASIPEYSRKSVLACMRAIVQKEGVLALYKGLVPGLIKVGPASAINFLVFEKSKRVLLYLKHRDDQPSKNNSNSTTSSFMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5I4</accession>
    <name>A0A8H7Q5I4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_002629</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
            <location evidence="2 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CGR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5I4"/>
    <dbReference type="OrthoDB" id="277961at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005579">
        <property type="entry name" value="Cgr1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03879">
        <property type="entry name" value="Cgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="23"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="47"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2186191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="123" mass="14946" checksum="48989A9929A7E841" modified="2022-01-19" version="1">MSEEKKMDMKEAVAGQVETVTKRVSGKNWKLQKTPTHRAQMSKKLRQTWEQRSEERKKKETIKKLERQMKDDKQADKDRKREITLERKKIKEEKERLEQLAAKMSAKRLQRRRKRDAKRRAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6Q4</accession>
    <name>A0A8H7Q6Q4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_002768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6Q4"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2186330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="71" mass="7948" checksum="93577ADCEAA26CCE" modified="2022-01-19" version="1">MQVDLSVQFPLLWALRRKPYPPPLSVMQPLRHSGKIYEEGPGGDLRAEEVPNIHYTGPIIALVKELALTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6R3</accession>
    <name>A0A8H7Q6R3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_002721</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6R3"/>
    <dbReference type="OrthoDB" id="376357at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="12"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2186283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="349" mass="39104" checksum="6D1A526C5867CAAB" modified="2022-01-19" version="1">MPAGKDFDPDVDYYKLLEVDYNSTHDQIRRQYRKKALKVHPDKNPSPDAAALFHALSQAYELLTDTQAKLAYDNVIKARVERKKKTEAMDAKRRAARDELEARENAAKKRKTDEMDAEAKYMAELARMRENSGRKRREEEEELKKMMEEEERAAVPQASEMDCTLKLKWKKKKQTFETSELEDIFQKFGPVDTVVLKKQGNALVAFKSIVGAHAAVTSKNTHPSLSVFETVDWATGEEPAIVAKLGETLKNNSVKVSSESIQASKLDFASLSTNSNNLSSKSKPLFGGASPAKPLFGAFAGVPTPVTFGNAPVTSDADFEAITLMKLREAERRRREEQVRQSEKEDGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7E2</accession>
    <name>A0A8H7U7E2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">High-affinity iron permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_002957</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7E2"/>
    <dbReference type="OrthoDB" id="4364at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632:SF2">
        <property type="entry name" value="PLASMA MEMBRANE IRON PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2171335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="40253" checksum="3E258099C48788E5" modified="2022-01-19" version="1">MAAQDLFSVPIFFILFRETTEAAIIVSVLLSFLKQVFSDDRVIYRRLCKQVWFGSLIGLAICLAIGAAFIAVWYTVASDLWANSEDIWEGSFSLVASILITVMGLAMLRTEKMQDKWKIKLAKSMEAQAGKQDLKTRTQRYAFFILPFITVLREGLEAIVFLGGVSLGEQAKAIPIAAIMGIVCGILVGYLLYRGGSLVKLHWFFVVSTCILYLVAAGLLSKAVGYFEQNAWNQVIGGESAEDGGDVINYKMTTAVWHVSWGDPELNTDTNGGWQIFNAILGWNNTATIGSITSYCLYWVAVSLALVYLHIKEKRDEARAPKYSKEEADEAVRKAADALNAKKKTESEGVADDETIDVGHEQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7W2</accession>
    <name>A0A8H7U7W2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7W2"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46331">
        <property type="entry name" value="VALACYCLOVIR HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46331:SF2">
        <property type="entry name" value="VALACYCLOVIR HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="27"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="280" mass="31246" checksum="49A7FC789924D079" modified="2022-01-19" version="1">MSFEQGESSFLDVPGAHLYYEKLGTGPVLVLVSGANGEHSIWAPLRQLIKDHFTVITYDRRGFSQSNLDGEQDYEHRLDTDADDLRRLIEHVTDTPAFVLGSSSGAIVTLALLQKHADSVKMAVVHEPPLSKLLPDADKWIPFFHDVYDTYKQSGIPAAVEKFTSILKNGPEVTTMKKMLSEPASEQAKQNIIYWFEHEFLPYTLYTPNIDAVKRSSDKIILCIGEKSKGEFPSWPPQELANLLSKSIFYIPGGHLGYVFEADGFASGLIKALNTQQTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7X3</accession>
    <name>A0A8H7U7X3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_006043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7X3"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802:SF1">
        <property type="entry name" value="IP11341P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2174981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="21997" checksum="4C4E0ED9E7E4E1BC" modified="2022-01-19" version="1">MVTFVLEQVKNLKAILSNADDTQSSDATSNALDPDMNTDGPMGPTRMYLSKPVIAAVSGHAVAGGLELAIWADLRVIDDTSVFGVFCRTKGVPLIDGGTVRLPKLIGYSAAMDLILTGRPVYPEEAMAMHLANRLAPKGMAALDEAIKLAKLLASHPQVCMRGDRDAMLNKDAEVRALQKEFENGINTLQSGEFQANVARFLGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7X7</accession>
    <name>A0A8H7U7X7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_006073</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2175011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7X7"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14500">
        <property type="entry name" value="PTP-IVa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000086">
        <property type="entry name" value="Protein tyrosine phosphatase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="99"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2175011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="408" mass="44333" checksum="C948EF787D8A44B3" modified="2022-01-19" version="1">MATRNQLSSVQRSLINPPTYIEYKGARFLIVDAPSNNNLPLYIKEFERWNVTDVVRCCEPTYAKEPLEEKGIKVHDWVYGDGEAPPNHIVDAWLALIEKRFGGEIGNHDGNEKTDGQSKKPPCIATHCVAGLGRAPVLVAIALIEEGMSPLDSVVYIRERRRGAINNKQLKYIESYKRRSKVFLLHLYHLFPFRLYFYFTMKFVAAAATAVWLSMTYAAAQVTSAAGNFNVTSPVENQTYVAGQTLPITWRLLGNTDLSSLQLEIVLTNSLSGNYTETVITAQADVSASNQQSANNETFYEHSINYPIPAMATLGNYNVSIQCLRTEESADVIFIPKDTNANTTIPIQIIAAAKTSSSVAPSASAGSSSSASSAAPSNPFASSADNVTPLHMAGFTLAALGAVAAIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U858</accession>
    <name>A0A8H7U858_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_001048</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
            <orientation evidence="1 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I NDUFA13 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U858"/>
    <dbReference type="OrthoDB" id="3308at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009346">
        <property type="entry name" value="GRIM-19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06212">
        <property type="entry name" value="GRIM-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2175401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="130" mass="14895" checksum="E33C53103AA04C00" modified="2022-01-19" version="1">MSTQATQDLPPPGGYSEVKYRRYLPKRGPSGLVIFAGLTAVCGFGFYRVAQGNLERRELKRENIWSRIHLIPLLTAESDRDNHRRQQAALAREAEIMKDVKDWKVGESVYNNTKYYTRPSVVVVPEDARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8Q1</accession>
    <name>A0A8H7U8Q1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Proliferation-associated SNF2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">INT43_005003</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8Q1"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006346">
        <property type="term" value="P:DNA methylation-dependent constitutive heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000015">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000577">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47161">
        <property type="entry name" value="LYMPHOID-SPECIFIC HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47161:SF1">
        <property type="entry name" value="LYMPHOID-SPECIFIC HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="252"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="636"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="111"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="522"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00053349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG2173585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="878" mass="99787" checksum="96924490814EC488" modified="2022-01-19" version="1">MLTTSDSNATSNHPSRAVESLSTSETHSETSPTSTSQTTPLPSDGDIEPVDDLITASMKKEEEELAKATEEEETNALAKAKQEFDTNVRENRLKSLHFLLEQSSAYATILGQRMEKQKEEAREKTAKASAKPEKQEQEPPKQPEAPVSRSTRSGEKAVSTPATKTRKANASDAKKRKAKENEYNLEDYIDGDDLKRRKVGENNIDDAIRADKEAAKAADEQRTKPSATAQQPALVTGGILRDYQLAGVEWLITLWENGLNGILADEMGLGKTLQTISFIAHLKAMNVSGPYLICTPLSTLANWVQEFHRFTPGINVLLYHGTKEERQHMINRKMQPKKQQQQDFPVIVTSYEIVMNDRKFLQRYSWKYIVVDEGHRIKNLNCRLIHELKSFKSANRLLLTGTPLQNSLAELWSLLNFLLPEIFNDLDTFQSWFDFSDMSKQSGRDRIMKEEEEDNVVSKLHMILRPFLLRRLKVDVEKSLPRKKEYLLYAPLTKPQKELYDAIIKRDLRKYLVAQMTSTDNNKEDDFEISDETNGPRRSKRGTQPNTYKDVGDREFFSGKENQKEEAAAVDNEALGKKHELSSVLKQVNGLHLQNIVMQLRKVCNHPFLFDWPIDRATNQPILNNELAAQSGKVLLLDRLLTALFERDHKVLVFSQMTKMLDILEDWATELKGWPICRLDGSVSQEERRQQIAHFNDPDSNVRLFLLSTRAGGLGINLTAADTVVIFDSDWNPQMDLQAQDRVHRIGQTKPVLIYRFIAANTVEAKILERATAKRRLEKLVIHSSKFRAPVASLSAGEKKERETSLRELADILASEDGEQVQIVAQGDKVVSDEDLEKLLDRSPKVFDAENSTSTGQFREIDTNELRDSKNEILATRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8V7</accession>
    <name>A0A8H7U8V7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heparan-alpha-glucosaminide N-acetyltransferase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8V7"/>
    <dbReference type="OrthoDB" id="2505607at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40407:SF1">
        <property type="entry name" value="HEPARAN-ALPHA-GLUCOSAMINIDE N-ACETYLTRANSFERASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40407">
        <property type="entry name" value="MEMBRANE PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="49806" checksum="C051738C776577C2" modified="2022-01-19" version="1" fragment="single">MDTARLLSNKPTSYDSVALSIGTVERAKPQRVVALDLLRGLLMILQSIDHAKAAFTTWYGLHESWYELPTYDSVWFFIMRLLTHPCAPGFAMLMGIGVTYFVRSRKALDWSDGRLLKHFFIRGSVLVLINLVQTWGMAGNFPGKVSFATTVLHALGVNFFTAAAILIASNHLYSAIKKSLTYHDHTNIDATSKAEKRANDLRIMVIFELAAAFMIVNVLVVPEPVPNGIVEGYGWWRYLLYLPGLSSFFISMYPAANWLGLTLYGVGLGLVMIRDKRSNRSNSVFNILLALGWFTLFLVIRSIGGFGNINPSLYGEPDASGILTHNPFFSSWIAFFNTIKYPPDLAYSALFLTANHIFLSLFFLLPTGPDANKYVSAIITNGPLLDFGRSALFFYVIHFYLYFASAGLIGRLIPSLKNPDTGMLAMNGWQFFIAWMTGLVILWFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8W1</accession>
    <name>A0A8H7U8W1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_005736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8W1"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2176496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="28993" checksum="600D78DCD66A8D8B" modified="2022-01-19" version="1">MTSSDSPTLAVITGGSRGIGLGIAKSLVQKHDILILSRTEPVADSVEELKRVRPEAKIEYVVGVDCVETQKALDATFERIDAVFADHKLTVFVHNAGLYLPGQQEFHKLGIDSSEGSEAALYYQNLYGMFFAQAIERCSKRMDKTGRIIGISSPGCNVNSPPRPGYLLPGSGKVLMEYYMRQYARTLAPKGITVNVVVPGHVLTSAWGPAFKNGKEGLLEWIKQRSPMGRPIEVEEVANTVAFLSSLESSAITGQAILCDGGLSNFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U907</accession>
    <name>A0A8H7U907_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">INT43_000187</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02735">
        <property type="entry name" value="RNAP_I_Rpa1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047107">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="16">
        <location>
            <begin position="378"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="289"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1383"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1412"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2172837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1702" mass="190439" checksum="77BE58C82A083557" modified="2022-01-19" version="1" fragment="single">RSTASVTMNISQPIGSEIDSVSFSFYDAAEIRKISVKQIVNPIIMDTMGHPTKGGLYDPALGPYSKRHICGTCSQDHFNCPGHFGHIELPVPAYNPIFFDNLYANLRAKCFYCHHYRMNRIQLHKTIAKLKLLQRGLIREAQRIDDFNIRVKKSKHVDEDDIADVLEEEQEGSESAEQFIERIDEYVEASINNKEATEFASQTYKITIINEERKQVMADFFRRCIAKKRCENCGGISPPVRKDGVAKIFQMPLTKKTQMIMDAKGMKLQDVLVKSPSKSDDMAIDSVVNDDSINGIADQSSSDESSSEEEEDKVDKMPKAKISKEEGEAPAGQQKYLTPHQIRDHMVCLFDSEKTMTTLMYGARNPRSPKLVKPVKASMFFIDVLAVAPTRFRPASVMGDKAFESPQNVLLGKILTSSQQVRESNTRVQTLAKNKEENKEEINRTFNYLVNNIIKLQHDVNSFIDSTKNPAPLRQGQLPPAGIRQTLEKKEGLFRKHMMGKRVNYAARSVISPDPNIETSEIGVPPVFAKTLTYPEPVTPYNVKEMMQAVINGPDKWPGATHVQYEDQSLHSLANLSVESRIALANTLLSPQDSTATASGSPYATRTQAINKKVFRHLRNGDMLLLNRQPTLHKPSIMAHKARVLPGEKTIRMHFANCNTYNADFDGDEMNIHFPQNEIARAEATLIANTDNQYLVPTSGSPLRGLIQDHVVAGVWMTSRDTFFTRDQYQQMLYGALRPERDGTGNGRIITVPPTVWKPVPLWTGKQVITTILKNLSIGKPSLNLKSNAKVGGKYWGPDGHEEATVLFMDGELLTGVLDKSQFGATAYGMVHSVYEIYGPESAGVLLSILGRLFTKFTQFHGFTCRMDDLRLTPEGDKWRRNLLDGGKNQGMDAHVEFLGLTDMAKEASEEELKKEFDLRMEEVARDDNKLAGLDNAMKSKVNKLTSSVIDKCIPNGLVKKFPKNNMQMMTVSGAKGSPVNVSQISCLLGQQELEGRRVPLMVSGKSLPSFLPYDSSARAGGYVAGRFLTGIRPQEYYFHCMAGREGLIDTAVKTSRSGYLQRCLIKHLEGLRVHYDHSVRDADGSILQFHYGEDSLDVIKQKHLFQFSFCANNSESLLQKYNPKAVVDILDMKEGSDYNKKAFKKQEKYDPALSKYSPSRHLGVVSELFTKELNNYMDKNPDNLPFSKSTPITKNNERFAGVTKSKFKALMHLKYLHSLVEPGEAVGLLAAQSVGEPSTQMTLNTFHFAGFGAANVTLGIPRLREIIMTASASIKTPTMMLPLLPNVTDAKAEQFCKNASRLTLAQIVDDVIVTERMTSKASSSMHRRSKVYQIRLNLFSEKEYKEEYNVSARRIKDVLESRFISRLETVIRKDIKDSKKAKADDVGKAIKRSKANQDNEDDSAPVKATVNDEDEGDGDATDARNAKRSAQHASYDAPDEDDEEVIKAMDQQMDEELELDALAEKDDDDKEDAMDVDDSEDRVLNNTTYVSKWKFDNANGAWCEFELTFPANTKKILMVALVEKICHEVIVHEIKGISRCFPYINPTENDKSRKLQTEGVNLKGLWQYANIIDVSCIDTNDIAAVLRTYGVEAARNAIMKEVAGVFGVYGISVDKRHLSLIAEYMTFEGGYKPFNRSGIESNVSPFLKMSFERTCHFLTEATIHGDYDTLDNPSSKIVMGKVVGGGTGSFEVMQPLVDTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9C9</accession>
    <name>A0A8H7U9C9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIH1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9C9"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050734">
        <property type="entry name" value="PIH1/Kintoun_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012981">
        <property type="entry name" value="PIH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997:SF0">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08190">
        <property type="entry name" value="PIH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIH1 N-terminal" evidence="2">
        <location>
            <begin position="54"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="310" mass="34343" checksum="60A21F1367E68F9C" modified="2022-01-19" version="1">MPKLEFEDNHPSSLLFNPQPAVNDLSADDQEALVSHFAQELEQDPSKLEQLAAQVIREQKAQQAQFKTMEIQPEAGFVCKTKTTTACKEWPIGSKVFINICYAAQVPEPNPAATEADIQKALQGDATATYQVPMSLGAPRRDHDRAGHACMVVDACVHTKPFVRAEGDLDYRLYIIELAIELIEDREKVELSREFTMPNLRSKGTIPKRMLQVPKGSLITDAPTTSKEPLFSRPDIHMVKKQLIVAYTMQAEVAKQVVVDIQPKAVLLSLDGQTHNTPLPVQIDVDSANNSATYHKTSKHLVLQLQGSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9Q5</accession>
    <name>A0A8H7U9Q5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_005967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9Q5"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13214">
        <property type="entry name" value="PH-GRAM_WBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2174905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="131" mass="14499" checksum="231342D6474A4283" modified="2022-01-19" version="1">MSINWTMVAQDGLSPVPLPAEKIFFKQSSIKFELDCNANGYPGNSGGAWQDANGTVFLSNQRIIYLPQRPTDTLKSFHVPLQSMKNCRYEQPWFAANYISGQVLPVPGGGLSQPGQVKLTFKEGGQCLIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9Z0</accession>
    <name>A0A8H7U9Z0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_005277</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9Z0"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07843">
        <property type="entry name" value="STKc_CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000211">
        <property type="entry name" value="Cyclin-dependent kinase G-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045267">
        <property type="entry name" value="CDK11/PITSLRE_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="95"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="389"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2173857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="444" mass="49908" checksum="F631102F85B7B89A" modified="2022-01-19" version="1">MSSTSRKSKWESDESDPESQHAVTKKHKSAKKTKARPQSARDSSPQPTVEPQEQARPKPIDETISAPISPVRRVVPPAPKPIAVSLHSCRHVDNYEKLNRIEEGAYGIVFRARDRKSGDIVALKKFKLDKEKNGFPVTSLREIRTLMLAKHPNIVNIREIVVGDKFDQIFMVMDFIDHDLKSLMEDMKNPFLQSEVKTIMIQLLSAVALMHDNWMIHRDLKTSNLLLNNRGQIKVADFGLARTYGSPLGNMTQLVVTLWYRAPELLLGAKEYSTAVDMWSIGCIFAELVRKEPLLPGRSEIEQLDKIFKLLGMPNDKIWPGFSDLPHAKNIAFVNQPYNNLRSKFLYLTEAGIDLMSKLLTYDPKKRISAEEALKHPYFAESPAPKDPAMFPTWPSKGSGEKRKTYLSPSAPQASHAGMEEDDALSGTLFGGTSESAGFQLRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAE0</accession>
    <name>A0A8H7UAE0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAE0"/>
    <dbReference type="OrthoDB" id="2283499at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="237"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="284" mass="31865" checksum="41B561BF8F40AA48" modified="2022-01-19" version="1">MDLGKLSNYKKSKSTLSLVSVANVEAMPSVMRVTSPTATSPTKGKRWSGLFKGSPFTKKEGKEASSKAQPKAKRISFPTNNNDTASTSLEDTGEYYSREGSYNRQIPGSAPSAHFEDIDRRPEQRRLTTNEEFEIASRFDRWKLQERGAPFEEEDEEEDEDEIAYFTPDGRLSSSPTKHLHHSGIISPDGDSHRPTSHSQISLLSIPSVGNQPYGRSHNGSESSHSRQTLEEHDYMDMEEALDNLSQNFRNIDAETLREILEEANGDYEQAVSICKQAIFEGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAM4</accession>
    <name>A0A8H7UAM4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutamate carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_000021</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAM4"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000008">
        <property type="entry name" value="Glutamate carboxypeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="206"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="6">
        <location>
            <begin position="395"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="5">
        <location>
            <begin position="646"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2172674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="768" mass="85120" checksum="961244F8B4A85AF5" modified="2022-01-19" version="1">MSPVEYGSSSSNNNNPITKTTQWLKSKITNDENSNDSGETQPLLLPPREGTERDEQKKRIFAFVMGMLLLICAVFGLLVLIAKAGSGRMTLKDAEQFMLAAPSNDSLRKYLDHYTSEAHLAGTESDLAQAEWTRDKFVEFGIPDVKIETYWPLLNYPKNHRVAIVSGPEHLHYEAKLREDVARGDKTSKGQQDVPTFHGYSKAGNITAPIVYVNYGRIEDFRLLESLGVNMTGTIALVRYGENFRGLKVTAAEKFGCVGALIYSDPVDDGPVGKPGVDNPAKSYPEGPWRSRSSVQRGSVQPFSLMAGDPLTPGYAATENATRIPIDESIGIAKIPSMPISWEDAIPLFKALDGHGLMIKNWVGGLTEVSYNVGPSEAEVNLLNDIENKVTPIWNVIGKIEGQDKDEKAIILGNHRDAWVFGAVDPSSGSAIMTGKIELAKILGKLLKKGWKPQRSIILASWDAEEYGMVGSTEWVEDHKDWLDREALCYLNVDMAVYGPYFVATGTPSLNNLLYHVTMEVQDPKTGQSVYDVWRNKSIRYSNSPIIDILGSGSDYVGFIDHVGIPSLDIRFVGESGIYHSNYDSLYWMDHFGDPTYEYHAALTKIWGLLTLRLASQSVLEFTATTYANELSAYFEQLLHVGYPHQFSKLKAAIDKFAEAAKLLDEEAAAADSTIDNTRPDVISSVNNRLALFERQFIDPQGIKGREWFKHVVIAPGLWTGYAAQTFPAIVEALDSDDETAIAYTEQRAALHIQKAADWMAKDNQHNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBV0</accession>
    <name>A0A8H7UBV0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_003609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBV0"/>
    <dbReference type="OrthoDB" id="10274448at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2179826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="265" mass="29681" checksum="A8286C7BB77D2851" modified="2022-01-19" version="1">MSVQTITTVAEPLLEGKFRWMELSHTGAYLEALYVLFDIAREELWMGDKYLNSVFYGKNVNRSSMVRLHNQNRPAVRSTYKIYGGLIKQGNSSVTIETQLYGTVGNSQLQLLASSIATIVVIARDPHVRTVKIPQDVHLPVLQDPSLYSSTKQTIPSNLDDKAVICTQQCVRPSDCGKTGHISNTKYAALFVDAFKANFKQDQAVESIIGLDILFEQEVFAPEEIAIWGWQENTKQYIFVLTRQDGSVGAKARISVQVEPVKPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UC86</accession>
    <name>A0A8H7UC86_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_004065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UC86"/>
    <dbReference type="OrthoDB" id="2281723at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2180276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="502" mass="57435" checksum="B16285A2E6D25BB9" modified="2022-01-19" version="1">MYLTDEQQYSIWKIATTFRVVSVLTGLAVLISYMLMVKFEPCIADRISLRLVFAANICVVFLTAWQFVIMALPITKPKACIATEFFLLFSDTTASILLMFVGINLMLVIVFSIPTSRRIEWGYYIITFVIGLAIALGITALSSTRIHDSFDRSCWYMVYYTNNNELRFTWIIRYMVSFAIVAISMVAFAITLNTLFTRKTWLNGGFDSNRNNQAVHPQKLYKSYRGHANSHAITYRKVALRCMMYSGAKLSYANSVLIFTKIWGLIYVLVALTTGEQNYPLLVIDQCASGTTGLLIGIVFFSDPAVISSASECREYLRCRYVDEYSEIMVTHLENGFQTKRRLSSRIVVVKTRRSTQLSQDTVLLDKTVAYKHPKWAKLVNSILTRVFKFKARPRRCRDPDNLEIITEYSMFKNQSDMYKEVEVPVYHYSPQSFPKEDEEIIAVPQPALAGKGGPSHNVQRRNTIDNHSVSFIDNDDIMPHFPKHILEGIHSDPDTHSDQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UD68</accession>
    <name>A0A8H7UD68_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UD68"/>
    <dbReference type="OrthoDB" id="2128042at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031606">
        <property type="entry name" value="Kch1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424:SF1">
        <property type="entry name" value="LOW AFFINITY K(+) TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16944">
        <property type="entry name" value="KCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2175598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="491" mass="56358" checksum="6FBBD7E8D485B221" modified="2022-01-19" version="1">MAKSGDKKPKTNSFMLLEKGPKWKREQVSDHKFDYIDVDEFYDPSCWTKMKYMTIFFSVIKSTLTYLADLWTAGILLISVDPQVIYKISPTASKWIYVGCIVLSFLLLALDIRKARLVIASRDISYALTSITAYRYYSIKSYPHYCLFDKIQSSKKSTDGFAFFVFFTLKGWKRLLFAEGPRQVVAIITVENILYSAWTKNGYFQFNTNWEEYGSSTTTRMQLILMTFTSLLWAFSMIMMFIAAIIYVPLLCHIKGNLKEYVCHKIDKRQKQIRKRMEQRDKKKVGGGQGTAMPAPRPTLPIVDESVISEKPNYANDYMASPYSNTKSPPPVYHTPYSEYNSSPYQYEDQYYAPEGGYHNDAYNNQYAHDVRLNERYARNDELYYDDRSYYGHNQGGQHATGEAYAMTTYHETPKFAPSPAPTPAPAPVIYNEVPAPQAYTTDNHLYYEPNDVRARSLADSSNYPPSPHSVSTATPAVPNARLPRNAGNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UF21</accession>
    <name>A0A8H7UF21_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_007648</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UF21"/>
    <dbReference type="OrthoDB" id="27832at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000037">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007193">
        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04050">
        <property type="entry name" value="Upf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="519"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="723"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="433"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="474"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="977"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1072"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1149"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="474"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="980"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1085"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1127"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1149"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1165"/>
            <end position="1174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2176994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1192" mass="134401" checksum="F129F72F4F41072D" modified="2022-01-19" version="1">MDSARRNDLAKANQEAWTKGKADPAKFRSLDSNIKKNTAFIKKCKTSLQADYQTQLLNDINKLSLEKYISEIVGAVIEGMAKCKTSVDVASCVEVISALHQRFPDTFTPLLTYQLAKLLAPPPKQTAAPISQEQKEKEDTSRVLRQRTYLRLATELWLVGVLRNVSDGVASLASANLEGMETHRDNVAGLVGSVSTINEKTKETKEDQSGNGFIYTILRDLFVNDKAQHTNLLLASSFLKNYGSDILGITPRKQRAAADQAAGDGAADDAASMPTSGQTADAIVSSTIREAFKSLMMDYHTSVEKHLVKEHKYVKKVDHRNHEILFTRGQLSDETKQNYEKLTKAYEKLLNNTQAIADALDVEMPELPDDDGTTKMSIISANGSNQFVDDRDVADNGIWEDEDAKSFYEKLADLKVLVPGVLLASMGKKAASEGAAVEGEEDAIKESDVNAVSEDAGEAKEEDLIAKMDQLEINDNDDVNGAETETEPSAIVDEKLDSADKDEGEDAVTGIKSTQTLQLDGLLARLPTLNNRDMIDSVAVEFCYLNSKSARKRLIKTLVSVPRTRVDLLPYYARLVATLNPYFPEVGETVLAALEHEFKGLFRKKSMDLLESRVKNIRYLAELTKFRITPAHTIFHIFKVALDDFTNQNIDVVCNLLETCGRFLLKSPETGIRMSNMLEIVMRKKNIQHLDNRYTLMIENAYYQANPPDRSAIVMKERSPMERYIRKMVYGDLNKKSLEKILKQLRKLDWADAKIVHILNKCFQKIWKIKYSNIHLISILASSLNRYHSDFGVQLVDSVLEEIRVGLEQNIFKHNQRRIATAKYLGELYNYRMIESALVFDTLYTIVTLGHDLGRPSRERFCPIDAPDDFFRIRLCCTLLDTCGMCFDRGSAKKKLDSFLTFFQVSYGVEMRGVVVVVMYILSKAKPPMDVEFMVMDTLELLRPNLHMIATYEDANEAVDHMLLEQLKTVQGGDAKVQEDGFEDSGPDSSSSDEGEDDELLDDKEEAVDEEEDEPMNQDMDDDDEDVVMLKKKDELAQEEDEEFEKEFSKMMSESVESRKFEKKSAMLDVPIPMHLRGGQDRRTTAANPDPTNGKMSFTLLTKKGNRQQVKQMEVPSDSLLAISTRNKQEAEREEQQQLKQIVLNYEEREEAHARSAAAEDRNKRFPQRPRKILHIGGGGGDAYTADRYVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFC0</accession>
    <name>A0A8H7UFC0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit DUO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein DUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">INT43_008500</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DUO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFC0"/>
    <dbReference type="OrthoDB" id="5599235at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013960">
        <property type="entry name" value="DASH_Duo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08651">
        <property type="entry name" value="DASH_Duo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="142"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG2180920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="209" mass="23910" checksum="67194A1468619D7E" modified="2022-01-19" version="1">MSQTTNTAELSISESNRKELGYSTASTTTSSNFIPATNKYTHNTPDSQEPMEDPNVSPEINARRRKELEAVRNLNMAVQTINSNFEKNKSNLQQFKQTVNQTNQLLDMWIKILSQTEHTKRLMEDPEWEGGALDATLAERDLQESRREKNDATQNQAQEQRRSLGEEKVKGLSRQMSRNRKVEVQKLSEAKQMPVSKARQSRNTKPATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFW0</accession>
    <name>A0A8H7UFW0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7719 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003021</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFW0"/>
    <dbReference type="OrthoDB" id="5597489at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056136">
        <property type="entry name" value="DUF7719"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846:SF1">
        <property type="entry name" value="DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846">
        <property type="entry name" value="YALI0B21296P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24841">
        <property type="entry name" value="DUF7719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7719" evidence="3">
        <location>
            <begin position="126"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2177774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="193" mass="21766" checksum="F5CABEC08B1A9A16" modified="2022-01-19" version="1">MTSIRSRKTVAKQEPLIKKIPNNPQSDISDADKWKIIEQSGVLKKAPMPEADGDDYEPSTVDYVVQAICFAIPFSLLFATFQVTVQVQYNEPWTVTQMGYRMLHVMPALLPIIYVTNRYKDSRFIQALMSIASVVVGAFLLYTVHKSPSLGQMLRAPGLATLWIYLIVQLDLTPAVITLAIVGVYYYYGLRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UG05</accession>
    <name>A0A8H7UG05_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UG05"/>
    <dbReference type="OrthoDB" id="43547at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033228">
        <property type="entry name" value="SZT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14918">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN SZT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14918:SF3">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN SZT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1078" mass="121787" checksum="EFD5C2674D2A3052" modified="2022-01-19" version="1">MEAGQGLAGICLMLLDSTGKPVSSIPLYDDDKLSQSDLADLKVVLDDDLKDASVLTSDYHIMIEVWSYGQCDAEILQKHIWRCCGQSVCHYLIRELAESADKMRRSEKLSNIERLHTMNYNQMLDKIFLALRYGADWGSTIISSLTKHLFLPPWSIDDILAQTSREIEQVTAQSASLLVHRSSDPIVKANLHHKLPWCLHNVKHHLQQVIREADEFVILNGLIDNSTTSSTSTAEPNERRGSHESESSGKSWGDRHSRRGSVESGVLERTSKPHKDEVAIRQILGGTANTKSEESSVHPRRVSISSVSSRVLVDLLQAHKKRCSDGLLKHCFIVMKLDTTRLSIFTFNWPNAVSDYIVGALHRIVISQESRAQMLSNIVHQKMGLFHHSMSFRDVLEPLYTTQTTLLPHSPKTGSSANSNRATPPTVSGRFATEKIKSQTAKPNEPREKVVTVEALNDLVYASGATSLFLESNDQGNSKDGDKNKEKVHTAARVLQPNDVLRDVVAEPSGTTAIAKSADPLLRHAQPFLETYLRQSRIRSAHEKAFKIYTKWINRCVDLSNIKSTQIITPSDLRIIMGSSRLLHFCRTPLILGTANENPATGKAGTHPQTDYAADGAAKWQTDLARTLLKEYATYLEGVGMHVISFDTEGSIDGELLEPNRSFKCPTVYLLKVFDGGSVLCEVRVNQGFVSVTLYTLHRRYGRLSLWAYNYEGRDTKRQRFKAFTEECDNFKTLIHVNSFVFDFHLRYIQRALVKLEPITSSINLLGVIRIFERIYTTPANYSRNRIVSGYINVDVHISSKDLLATAYRHANKVGSKVLHYQNKPVACFVHSNDPSFAENANFPTTNTPYQFSLILCSLDNGDSRHSDDKLRLRYFVIITYEDADIAVNDSKPLPSRILKAHPGIGHHDPLDELLAPESGLTLGKVVKGARAKIDLIVSKLVHYHRNDLTWSEMYERTQYSNPQELITTLQKFDTLNLSDSEPNFAKYLQRKLPWDKILPMIGKYYGGGLRELDYKGEKHLLLFNARYMDYLMHIRWSSDISFQMVSREPRLNALEPAERQQVADIGTFIGYALWKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UG47</accession>
    <name>A0A8H7UG47_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UG47"/>
    <dbReference type="OrthoDB" id="18320at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06869">
        <property type="entry name" value="PX_UP2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047168">
        <property type="entry name" value="LEC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024554">
        <property type="entry name" value="LEC1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024555">
        <property type="entry name" value="PX-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12825">
        <property type="entry name" value="DUF3818"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12828">
        <property type="entry name" value="PXB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="3">
        <location>
            <begin position="175"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="789"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="810"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2177984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="852" mass="98595" checksum="F6E9C2DBB68AFDF4" modified="2022-01-19" version="1" fragment="single">YDLDPKETHYLKRELVTQEIHSELEKLVQSASFQILLDQNTPLAESELPFLRYIFNTLVLDFPFLKKEQDDKFWVKCETFLTEFQKRRIASSDKNEQSQRKRMEYKMEKMIVILLGAAIKTVQGKEEGIKVDQQMLSQSKTEEQKRQDNRLTRDLIDLENEDNYMQWVGTNGLDINIVTVREVGEKRTLREKPHAEFIVQTYFEHDEDPNVAIYVAKRHGQFRQLQDDLKKKFPTIDIPHVPAKSRDSEKSHALREKDRLSLRAFLHRVAIHPRLADSDVFLEFLRADSIELNEDERNDMENRKRIDKIRLEEEKKFKVEVDKQVEQLNEQLETLKKKVLAPGGLTEMFNDVKTSERIQDLPSSLQTAFEWGKINFAFVLHTHFVTSDAATENLMNLKRTHALIPYRTLRTILKISNPMAMVKGVLDLFMAQPFGGRSLFQRIIMANLIEETKEAQKNIDTVEKTIDDSGLCKKIYNSVYEASDAIIEIEENEDLSPIMKTLSLLQNDDIEPPLTAQQITKVAFAAQKNQKESRRLVKRLHQLYVLYMRKRDQEMLTELVFQGNTGDLLKDIFAIFYQPLAQVYKAANIGDSIVELSAFIDDLILFVEQIDVDGKHLSLAYFTCTCTCTCKLTLTTSLPDVGNTVQPFIQLITKHEHSFYRFVHNVHAQDKTGLFDDLLAYIDKLFSMMANGLPGKVDMEKLVKENLEDPQYPELKKEINTLCNYHLERKIKHMQRTRRKVLEGTGISAELEVDSEQTMLELMGDKNATMGVMDDMEELDFLSDSDLSDDEEDALYSSDDSINEDQDEAAVMRKEQQRRQKLDDESAIPPPKLAVLPKLKPAFTRAVASLMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGR5</accession>
    <name>A0A8H7UGR5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_007380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGR5"/>
    <dbReference type="OrthoDB" id="1695362at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18870">
        <property type="entry name" value="NUDIX_AcylCoAdiphos_Nudt19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE NUDT19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="TESTOSTERONE-REGULATED PROTEIN RP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="40"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2182450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="358" mass="40473" checksum="4BF7363067C0E142" modified="2022-01-19" version="1" fragment="single">SPAPLKSVHSTVHTQHVKRDPPFCYVSQNGFTNNTYVPYSDQKHTSLIVAAPIPASQVKSSSACNYRVLMMKRNAKSSFINAHVFPGGNIDEHDYDSRWSEIIAPGGHAYYDEESKRMLAHKICAIRETYEEAGLLLTNPPNLHIPTSWREKVHADASEFRKMCAEHKMAPSACNLYHFSNWITPVMEKRRYNTQFFITVISEAKGEEHTLIQADGGETIQLDWYTPEEALDAWKRGEITLYPPQWYSLHILKQTPRYQDIVANAGVGAFRTRTGKVVTVMPQPQGAPEGSAEEKEGFHIFLAYPGDSTYEGPGLKTTEHGQHRLYIKKEGAKFTDMKLVRTVDVDDIVQDDTMKANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UH88</accession>
    <name>A0A8H7UH88_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_003566</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UH88"/>
    <dbReference type="OrthoDB" id="159449at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000027">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="268"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="550"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="687"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="835"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="930"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="761"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="700"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="711"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="835"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="877"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="936"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2179783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="990" mass="111539" checksum="A5B6A116B03326BB" modified="2022-01-19" version="1">MLKNSVQDPGVPLPGVRSDSGALNKSDSTRKSQLLGALGSQDTTTSPSLGEETLKLLKTFQNNPSDANMQEILLREDIHSPSQSPMPSKSLPPQRLAVAPRPRKNISMTIAQRRRIPNALPNFRIYGQMRLDQTKVDTTDSPVLKRLEEENAKLPPQESTDFILAQIERQNALLDEDPKSVCIQSNGLKAHFSTLQNLITDSTNTPSQEDEDVQANIPTSPLKTAFQYTPAADDGSNIDWEFWGALIDDFSTVALKLPHLVSAKLRAGVPQKLRGLVWQAMSQAASLNLEAVYPQLIQENSPYDRVIQRDLARTFPHVEMFKKEGGDGQKAMEHVLKAYSLYDSYVGYCQGLAFLVGPLLMNMPEQKAFCVFVRLMETYDMRTMFTLNMEGLQLRLYQFTELLAKILPKLSDHLSELSVHPPMYASQWFLTLFAYSFPISLVMRIYDIIFAEGAAETIMRISIAMLKKSESAILAMQEFEEVLDFLTSKLHEPYQNNSTKVISDAMALSDVITRTELDLLSEQYITEVEEEKKRSQEVMAVRLNFWKRGSSPSNDETKKKNRESGKWLWDSSGPAKDKRNTSDEEKETKKSARKRESIGSLIRGGGGSSSSLTSPQLPPAASCDSFISQSAKADALLHRQIEDLVSALSQLQKDNMQLSQEKLELKLLNSDITNERDNMRRKLMHLEKKEMVEEPSAIESFDRPASRQDDSTSVNSDSSHEGASTATSFSESTRQTLASSAPDIEDTHVPRDLDAETRLLVFKLQQKYERVSEELVELKSQHEMSKDAQLALVDKLLAMKEEHERIDRARMQAEKEKSTMAQEYENLRRLMSEREKGYMEKERERKAPTKQHLENERDNSRRRAEVGESSPPTSPLNRRHTMHTYKPHGDDDAERCSELESMLVEAKLRIVELETAASHKPATVLTKKVASRPLNGRQSLDTHNGPSHPTVDVPKLTRASTDAFPTRAPLPKRASLYGKMWSVLGSQNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHZ9</accession>
    <name>A0A8H7UHZ9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007352</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHZ9"/>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000001">
        <property type="entry name" value="60S ribosomal protein L22 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF31">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL22A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2182422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="14085" checksum="625A19507F021AE5" modified="2022-01-19" version="1">MAPAKSAAAKKAQKFVIDCSGPANDKIFDAAAFEKYLHDRIKVEGRTNNLGDAVKITRGGDSKITVTANIPFSKRYLKYLTKRFLKKHQLRDWLRVIATDKQTFELKYFNINQGEDEEEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIG9</accession>
    <name>A0A8H7UIG9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIG9"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="69"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2181028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="302" mass="34335" checksum="CF4658E04097B7CF" modified="2022-01-19" version="1">MHFVVYIWLKCRVLLLRGASYILSILIIRPGNVGPTHRQAIPGSAPEKAAFFFPPSYSKDSGHRHPVYIHIHGGGFVCGPTCDDRQFCHYVAKEADCVVISVAYRFAPEYPYPTALQDCQAAVQWILKEYQPTHLVIGGYSAGGTLALGTVQLFQNTFDMVMATYPALDFSRGSLHEFKEQNPLIRNMYHRAYLRNTPDTDESLRNPLLSPRYIPESTLPKSIAIINTENDPNHKDITMLATRLKEKQPSTIYKYYAGAFHGFMNVPDFFLPEKMKQQKWDAIDTIVVEMKRVFSEPSVLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UII2</accession>
    <name>A0A8H7UII2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UII2"/>
    <dbReference type="OrthoDB" id="2372493at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="121" mass="13211" checksum="235198A17EC9F924" modified="2022-01-19" version="1">MKSTQSSGHEPREAPWSQPQPTVGQDPWNRSPEARRHPELYSTAHGTSGSQMEDDSVPIMPTTTAGNGNTAKEARGSKEHVPGSKDALHCERDSTGLTFGHTVHKQASRRRSSVLRDLSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIV0</accession>
    <name>A0A8H7UIV0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_008986</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIV0"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="10"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2181403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="385" mass="42484" checksum="78A9920099A9DA4F" modified="2022-01-19" version="1">MDNATNHPKIAVIGGGPGGLILARVLKVNGLQCTVFELDAQAASRAQGGTLDMHPESGQMALKAAQVWEEFQKFARYEADTMKLLDKTGKVYLENVSFSDNNDHPEIDRLQLRNLLLDSLDESTIQWNQKVQKIIKKDGYFVVVTAEGESGPFDIVVGADGAWSKVRAFLSTTTPEYTDLTFGDAFIPNIETRYPDIATLVGGGTMAARESGISIFSQLLGDGSVRSYFILSTKDRDLSSLKSANSEEIRQYLLQEYADWDPSLKKIIEVSEGVILRPLYVLPTGYRWKSQPNITLIGDAAHLISFFGGQGANLAMQDGAELALAIATAVHNDHDVHKSIQGYEEQMWKRAEMASKFSNLGIQNSFASNPAQLMMERFKGKLHQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJ86</accession>
    <name>A0A8H7UJ86_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJ86"/>
    <dbReference type="OrthoDB" id="2285859at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2183757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="27731" checksum="0C6FCA7843E63265" modified="2022-01-19" version="1">MLLLPAEVIVHILAFVPLTSFRSLYQVFPQELLDEALKSKVRQQPQVIELVSTNLHELVANETLSSSKLRNESSVPLQYIGFDTLNQVLWFTPDTPNQFFKVKHGFVSHGKLIVRANKKSLHKVIMSLWDVRKKLPPKRSGSLSGASQVDCSEYTEEVVVRNRDFILDGYISTCKAQGQVRRTPLYNKLAGLIPPPLPSSYSRKLPSVAQITARSRWEPQLPNPTCGLFIVEHVALSVPAFLELFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UK53</accession>
    <name>A0A8H7UK53_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="9">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_000630</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="9"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UK53"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF28">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="42"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2184717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="502" mass="55632" checksum="44292FC61F742EE2" modified="2022-01-19" version="1">MLRSVLNTPIRNGAMRSLSALSVQMRGYAFPAGQKELLNNRLKDTDPEMFDIIENEKKRQRNGICLIPSENFTSRSVMDALGSIMQNKYSEGYPGARYYGGNEWIDKSELLCQKRALEAFNLESEKWGVNVQSLSGAPANLYVYGALMKPHDRLMGLDLPHGGHLSHGYQTPTKKISMVSSYFETLPYQLDEKTGYIDYDGLEKNAKLYRPKIIVAGASAYPRNIDFARMRKIADSVNAYLHVDMAHISGLVAAGVLPSPFEYADLVMTTTHKSLRGPRGAMIFFRKGVRGHDKKGNEIKYDLEGPINTSVFPGHQGGPHNHTIAALAVALKQCKEPIYKEYQQQVLDNNQAFAKAFTSKGYELVSGGTDTHLLLVNLRSKGIDGARVERVLELVNIAANKNTVPGDKSALIPGGLRIGTPAMTSRGLKEEDFAKVADFIDRAVQIALDEKKKVSSTKLVDFKKHIGNGENISALQDLKKDVISFSESFPTVGFNEDEMTYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKN0</accession>
    <name>A0A8H7UKN0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_006298</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKN0"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000016">
        <property type="entry name" value="Derlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2183293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="268" mass="30921" checksum="538509D3E614AF2D" modified="2022-01-19" version="1">MPTPLETWFYEIPPITRAYVTTACLTSLIVQLELVHPLKLLLNYERVIYGHEWWRLFTNFFYFGPLSLDFMFHIFFLARYSRMMEESHFRSRAADYAWLLIFSAVSLLTCSFFVPMADMQFLGSSLAFTLVYIWSRRNPYIRLNFMGVLVFSAPYLPWVLLAFSLVINGHIPMGDSLGIAVGHVYYFLEDVWPREPHSGGKRYLQTPRILKWLIDSNTPNDDLDIHDDAELPPTADNTLNNDMTENNNGSGRTHAAGEEQAEPEATST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UN63</accession>
    <name>A0A8H7UN63_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_000872</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UN63"/>
    <dbReference type="OrthoDB" id="30195at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="124"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="206"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="6">
        <location>
            <begin position="485"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="597"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="611"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2184959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="659" mass="73050" checksum="57140452355D8B04" modified="2022-01-19" version="1">MGRNQFKAKQDTSVAPKAVEALLSAFDSPSNDSFALVTQGIDRHRLRIFDPRSSTIKDDFSSNKEDKFTCLAWGTSKSDVDLSKTSKKKRKTSSNSQKVLALGLQNGSIAIYSPAHGRVIKTLSGSHTLPVNDFVFNKAGTVGYSVSEDHHIVEWDIEDGRELSKWKADSKSVNKLNLNHSETKLATAGHTINIWDLATKKISKKFTGHASTITRVVFGPHDDICVSIAENDRYVNVWDCSNQSEDSSNITALTMDTDIVHVDISPANNTVLALSDDGLVGIWQNASSPTSASAASSGPKSKRKIRSSTRQPDTTIKVVSSEDESTTIPILLTAFMSGSDKDFVIIARGSTLKPSFETVRFIDSSEALIQDILLTRQSVNGYLVDKSSLAANNLKTTQKKYDESSVTVLGNTDFSISNPSMAQDEDSEDGDENEQSIEQKLSVLAVDESAEGADDKDVQNRKQKKHQPPPASSLQQMLVQALHSNDTQLLEACLTHSNPEIIRNTVRRLPTAWVIPFLQQIVDKFQERPNRGKVLLEWIKAILLIHTAYLMTVPDLVGKLSNFYMALDARLGVFQKLLGLHGRLDLVMSQIDMRSHYAQEDTTNEPINVYVEEDDEDEDEDDMAGEEDEDMMEYDEDDSDEDEDEDDDEDVDSLDSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UN90</accession>
    <name>A0A8H7UN90_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_002431</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UN90"/>
    <dbReference type="OrthoDB" id="200404at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2185993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="174" mass="19947" checksum="85E077C3A7B3A20D" modified="2022-01-19" version="1">MFRATFRVAIDVMPSTKFKPPTPAGHTTIPYTRHHAADPNEEDIIDEALNLFRANCLFRNFEIKGHADRVLIYLILFISECLGKLSKSPTPGEAVKQLSTLAVSNFAIPGDATFPLNAMYSPPRDRSQQDQLRQYIQQLRNEMAIRLVDRVYVDGKPSKWWMCFQKRKFMGLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UNF0</accession>
    <name>A0A8H7UNF0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UNF0"/>
    <dbReference type="OrthoDB" id="2246061at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034257800" evidence="1">
        <location>
            <begin position="19"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2186173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="233" mass="26488" checksum="3B60835473B07B9E" modified="2022-01-19" version="1">MLLLRTVVLSVLPILAAAAPIFVESRKSDVEPASYLIFESLCEYYENVSDEVLEAATLEMLYEDGLFDALKEDIGPVDARPLLQSTLRVHFSINHANILSQIRPLVSEILPTLLPLDQHEQDEDWLPGDRTAEALVPALYNLNQVMGFRLGNLMKTDALLHDLNERSALACRISDPFMVPIQKNLHVPSRNLVRSRAYLFSGFESAKQQLWTQYDEQIDDVIRVVMEDFMDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UP54</accession>
    <name>A0A8H7UP54_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylmalonate-semialdehyde dehydrogenase (CoA acylating)</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_002372</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UP54"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000003">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase [acylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="53"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2185934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="538" mass="58386" checksum="3C9E91A225FA95BB" modified="2022-01-19" version="1">MLSSLFKSQAQRAPLRPYVRAFSTNYPVLQQAASAAATEAKVATTKNYINGEFVESSTDRWIELRNPATQELVTMVPETTREELDAATSSAQHAFKEWSQTSVLSRQRIMLDLQYLIRKNQDRIAENIVLEQGKTLIDAKGDVFRGLQVVEQACSLTSMLMGEKLTVAKDMETYTFREPLGVTAGICPFNFPAMIPLWMFPLALATGNTMVLKPSERDPGASMMLAQLAAEAGVPKGVLNIVHGSIDTVNYICDEPRIKAISFVGSDHAGKHIYDRGGANGKRVQANLGAKNHGVILPDASKQSTLNALAGAAFGAAGQRCMALSTAIFVGEAQDWIPELVDRAKALKVSYGMEPDTDVGPLITVQAKERVERLIQSGVDQGAKLLLDGRGIKPKGYENGNFVGPTIISDVMTNMDCYKEEIFGPVLVCLKAETLDDAIEIINANPYGNGTAVFTNSGPNARKFQQEIDVGQVGINVPIPVPVPPFSFTGSRGSILGDLNFYGKSGVQFYTKLKTVTSLWKESDADHTRSSVSMPTMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCD5</accession>
    <name>A0A8H7PCD5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:quinone oxidoreductase/Mrp antiporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_005308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000024">
        <property type="protein sequence ID" value="KAG2171242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCD5"/>
    <dbReference type="OrthoDB" id="2394882at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="2">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="258" mass="28515" checksum="3D583838BA1E6CF5" modified="2022-01-19" version="1">MFLIIGIWGARERKIHAAYQFFLYTLLGSLFMLLAILVIYFEVGSTDYQVLAVADISETRQRILWLGFFLSFAVKVPMIPFHIWLPEAHVEASLAGSIILAGILLKLAGYGFLRYSIGVLPDASVFFTPLVYSLSVISIVYSSFTTLRQIDLKKIIAYSSVGHMNIVNLGIFSNTIQGIEGNIAVPLTSNFVGEFMTFAGAFQQNPVLTIFGALGMILSAGYAIWLYNRVAFGSYSVYLKSAGDLNRREFIANALSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCH7</accession>
    <name>A0A8H7PCH7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCH7"/>
    <dbReference type="OrthoDB" id="5590091at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="275" mass="31043" checksum="E7210661751D078F" modified="2022-01-19" version="1">MMHTVARSTHSLKEKPAPLAINPSLDSQTLSKPKTGLTIDTGLMTPSEPVSIPYNNRNPAIVDPLTPPLTATSPECTDDDYELLDHLQNDEDFIESIATIQSTFLWDGICRGRFLSFPHLALHGSAHTSQMMRVLESWLCDKLMQPQLGDLLPILEESIPESCRSIMDMMHKEKQLLRPFHTCLIQIRSGHLYNLPLISNGDAFIDVEEFIRDYPLFVDVCIKIVPRHLSRGLALRDDVEHCRLLLSFETIVGKSDQLEQSQPYLLSELVDVSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCJ1</accession>
    <name>A0A8H7PCJ1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCJ1"/>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000030">
        <property type="entry name" value="Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050135">
        <property type="entry name" value="dGTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045509">
        <property type="entry name" value="HD_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF4">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19276">
        <property type="entry name" value="HD_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="98"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="HD-associated" evidence="2">
        <location>
            <begin position="240"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="57402" checksum="260D0627F9A25CB9" modified="2022-01-19" version="1">MSGLGLNHNIHSIFPYDGGSYGKIFNDPIHGHIRTRLDDVQTQYVDTIQFQRLRELKQLGACYFVFPGASHNRFEHSLGKDQWLTYINDKHSHIRKGVSYLAAGVVEHFQHSQPELEITKEEAESVKIAGLCHDLGHGPYSHLFDNEFMPLARPSRKWSHEQASEMMLQYLIDDNYIDIDKDQINFIKDLIAGVPKSSSQKSERGFLFDIVANKRNSLDVDKFDYIERDCYNMGTKSSYDAKRLIWFSRVIDNQICYHEKEVYNLYEIFHTRYSLFKQMYTHRKAKAVECMITDALLEADPVLKISEKVDDEYEYLKLTDDILKTIQFSDCEELKTAREIVQRLRTRKLYRFVDEFLIPAGMEQYLTKEKITAQELVSYQSDNAKLTEKDVIIEWLVINYAMKDRNPMDSVRFFSKRLQDQGSFTIPKQQVSSLVPSQFQEINIRVFARNPEKSKDIRKAFCRMMKTYNMNEDMKQHLDNWLIARQTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCS9</accession>
    <name>A0A8H7PCS9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCS9"/>
    <dbReference type="OrthoDB" id="2284644at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="119" mass="13593" checksum="7D45D44863712E60" modified="2022-01-19" version="1">MASIKLAKNSLDTLLKARPSSKDTKSNNTADAPSSLKRKQRMALPPTKTGLKKIKHEMRYGHQKNVRSKAKLAESRQNPVGRVHKDEQKAQEKLERNVRYMTSVLKASDTERKLRQQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD44</accession>
    <name>A0A8H7PD44_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Saccharopine dehydrogenase (NAD(+), L-glutamate-forming)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_008072</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 1/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD44"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004753">
        <property type="term" value="F:saccharopine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12189">
        <property type="entry name" value="LKR_SDH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000087">
        <property type="entry name" value="alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="9">
        <location>
            <begin position="19"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="8">
        <location>
            <begin position="190"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2171692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="936" mass="102408" checksum="50FF1B120EE61139" modified="2022-01-19" version="1">MYRCKPGVSRQYRSITTVALRREDKSRWERRVALTPTAVSSLIKETGAKVLVQPSTNRVYNEQQYVKAGAQISEDISSADIILGIKEVPVDSLIPNKTYLFFSHTHKGTPQNMPMLQSILDKKIKLIDYEHLTDASGKRVVAFGKFAGNAGMINSLHGLGHRFLGLGYNTPFLNVASAHTYRSLQDAKAAINAVGQNIASDGTPEALGPMTFTFTGGGNVAQGAFEVFQGLPHEIVPVEDLAKIVADKNPKLNKLYAARANIGDYIVRKDGGKFDQAEYFAKPELYESIYHTKVAPFTTCTVTGAYWDAKYPRLLTNEQLKELQLQKQLGKLDKGRLVALTDIVADVKGAFECFSHATPVDEPFYYYDAIKDVVHKDVEGPGYQVMGVDILPAELPMESSEHFSNVLGPYVKELIMNNNAEAASTLKNATLAEGGKLDKKHEKLYDLLGNKGPSVSATGAKPRKNVLLLGSGLVAKPLVERLLKRSDVQMTIASNSKHEANALAQSFANANTADLDIADTDKLDKLVSGSDVVISLVPAFLHTKVAEACIRERKHMVTASYVSKEMQALNERAQEAGVSIMNEIGLDPGIDHLSAMKIIDSVHDAGARVNSFVSWCGGLPAPEASAVPLGYKFSWSPRGVLTAGNNDATFLMNKKTHYIPGKDLLKEHFSTVPVPTKGFAFEGVANRDSLSYIDTYRLGTLKDMDTMFRGTLRYQGYSDLMHAFKKLGLLEANNMVPRSDNWSTFFDSVIDLKHKDDNSRRDAILDRLELSANNPLVPKIMEALDWLSLTNSGNTTAPVFPSGSQIAPLDAFSALLSSKLAYQPGERDMIAMHHEFGIVGKDGQPQNMTSTLITYGDSQHTAMAKTVGLPCAMAVELVLDGLVPEHGVLVPTAKHVYEPILHELEKEGVKFLEQTKTGTQQEQALFPGGSGLWDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PE55</accession>
    <name>A0A8H7PE55_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_004801</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PE55"/>
    <dbReference type="OrthoDB" id="3056235at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="6">
        <location>
            <begin position="40"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="127"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2172260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="367" mass="40811" checksum="D7519363C578D7B0" modified="2022-01-19" version="1">MNSGPTPPMGLARPSRDNNHYRLGKVDVVSICDIMIPSTDCPLFFFLEVMQHPLRARCCGFGEKDRRPIDPPPVLQLFVEGEDGEPKTVSSLDISFFLIQCDLYSADGSEERNIVLHPSVIPNTHFTMGSSSSSNSPSQVSTTTQSESSRQGGSLSTVISLRNPTPTRNLMGSLIANAVQLENPQKTTGIYFVFPDLSVRSEGRYTLKFMFFDLTLGLVEPLTMSTKVQAEIYSQPFTVYSAKKFPGMTESTELSKCFARQGIKIPIRKESRFKRPSDRFYGANALNSLNDSPSKKGHADQAKIDEKINSPDDDDEEMSTVQHQLVKVDHQEHPEEGSSGTNKKTSPVPYKRLSISSYLTQPQEDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PE98</accession>
    <name>A0A8H7PE98_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_004845</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PE98"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2172303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="268" mass="29921" checksum="BD29471F88940621" modified="2022-01-19" version="1">MPPYNAPNQRPPAPRNELLEFYHSIPPITRALLTAGIVVPLAPMLGLANIYSLLLSWKAVTTKFQLWRLATCFFVNRIDINWAFNLFFIYRSSSQLEQEQFLGRTADYFYFIIVTSGVQVAAAYLLDQHVLSSGLMMAVSYLWSQKYRGMPVSFMFGLRFQAQYLPLVQIGYEFLMGGGGIPIASMLGCASAYLYDYFTTEYPRAAGVRLLETPNWLRSLFPATTGNRGGFANNVAGAANVNVQAGQAVEPANSIFGRHQWGRGQRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEH0</accession>
    <name>A0A8H7PEH0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEH0"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2172421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="131" mass="15181" checksum="101480F1028267BA" modified="2022-01-19" version="1">MKVVTKCGESQSFHDWFSDIQKILNTIASTLSVSKEIRTYARHLRNYNNLQQCALERHWLKAQQSSPDSCGSHDSTISTPSGTDSLYINNKRKYHEIYEIPQNIKRHISDIKSTLKLKEIEQGMKLLKNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFA8</accession>
    <name>A0A8H7PFA8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_000236</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFA8"/>
    <dbReference type="OrthoDB" id="16510at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2172886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="115" mass="12706" checksum="DC6481E5BDC54098" modified="2022-01-19" version="1">MSADAQGSGSEDVHKYVLPYIMHNAKTMQFARACLAAISGSAAGILGLKNFQGFAFYAVSWIFMSFLLLAVKTQFKPHLFFKGGVKDIFTEGLIGGLLSYILFHTFLYGLVHLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFI4</accession>
    <name>A0A8H7PFI4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclin-dependent kinase 1</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_000082</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFI4"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000574">
        <property type="entry name" value="Cell division related protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000027">
        <property type="entry name" value="Putative Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="39"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2172735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="339" mass="38685" checksum="13DDBFD9272FF18A" modified="2022-01-19" version="1">MGDENQRPDNTSTTSATTLTKTLKKEQVGKEAKSVMEGYVKMDKIGEGTYGIVYKAKHKASNRIVALKKIRLNAHDEGVPATAIREVSLLKELKHENVIRLLDIIHNDTMLYLVFDFLDIDLRKYMDTAGKEGMTKVHVQSFMHQLISGLNYCHSHRILHRDLKPQNLLIDRTGKLTIADLGLSRAFGIPMRTYTHEVITLWYRAPEILLGSKHYSTSVDMWSVGCIFAEMVTLRPLFPGDSQIDELFRIFRILGTPTEEHWKGVTSLPDYSPTFPRKSLTKYEWKGEELENVVNYLGPHGTQLWKSLLAYDPAHRVSAKAVSVKNVERQAKNYYSSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFU3</accession>
    <name>A0A8H7PFU3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_004548</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFU3"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="5">
        <location>
            <begin position="61"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2173174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="239" mass="26684" checksum="37DD1E73EF532524" modified="2022-01-19" version="1">MEDEIDLDLFGEFTEEEQQGREARVQKLKEQLQDSIANLPQDPSQRTTAQNRLLFRQAFSPPPFIISSLLSPAECRGILDTLSHDTHWLTARHSAFATTDIAVSSVPKLASSLPGLLKSRLLETHIAPKFGFHPQLDLAFRDLFIVRYCHDAQRGLQMHTDGCLISFNVLLNARTEFDGGGTIFETLDAPIEIDQGDCVVHDAHVKHGGMDITRGTRFILVGFVDTVDTLKKDTIARSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGH6</accession>
    <name>A0A8H7PGH6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protein PBN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_004598</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGH6"/>
    <dbReference type="OrthoDB" id="5546453at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042322">
        <property type="entry name" value="Pbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533:SF1">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00780">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2173224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="224" mass="25268" checksum="DBE390322C56DB66" modified="2022-01-19" version="1">MATHTIAPAAGFHPHIYTNITFKHPPSRLDCIFDIIYIIPREAFVDANQLTDLKLSKHLVVLNESDLEAPAERVRGGNLVAVRYEAEDYLMSLGKEVTIDLPLHMRYQQPDSLWTHQTVAIPVPKVGWTCSIEPYQKPNSIPPLPSIDFHLERDSRTTFDEIESSVVGNMTVSIPVGRTTDTNTVKIGTHVIVLFGALWIAWAIYSAVVKRKRTELKGKRRKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGU8</accession>
    <name>A0A8H7PGU8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGU8"/>
    <dbReference type="OrthoDB" id="10527108at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="148" mass="16672" checksum="06ACEA289F2B1207" modified="2022-01-19" version="1">MLAYTAYKAIKDKKKKRDQNKNRQPQYQQQQGNGDYGHTPSKNSQTSASAHSSYSAGYSQSSSNDSQHYMQSPPAFNGRSALAQSPHGPNNGHSHYTTAEQQRMQQELSYAQHNQHTRQPQYNGPQSANALTNSQVQQYHQGGDPRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHD9</accession>
    <name>A0A8H7PHD9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_005062</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHD9"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF1">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="22"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2173644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="132" mass="14687" checksum="30946A8F50825EBC" modified="2022-01-19" version="1">MNGDEVIWTTTNLEKTPSPWNNYGKVILIGDSAHSMSMARGEASNHAIRDAAELCEYLMAVNSGKLTAVQALSDYEKAMIKRGASAAKASRDAIFSRHAPGKFYSNFVMRVASTLFQTYLNVNTWINSFWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJ30</accession>
    <name>A0A8H7PJ30_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Cu(2+)-ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">INT43_005950</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJ30"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000144">
        <property type="entry name" value="copper-transporting ATPase 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000043">
        <property type="entry name" value="Copper-transporting ATPase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00943">
        <property type="entry name" value="CUATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0187">Copper transport</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="689"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="736"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1105"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1134"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="20">
        <location>
            <begin position="6"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="20">
        <location>
            <begin position="78"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="20">
        <location>
            <begin position="151"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="20">
        <location>
            <begin position="259"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="20">
        <location>
            <begin position="333"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1199"/>
            <end position="1224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG2174888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1237" mass="132927" checksum="84F15C41B00E9C3F" modified="2022-01-19" version="1">MSHQNTQVDLPVEGMTCHSCVNSIQNALSQNPHIINVNVQLENATAHVQFDADHITVNELVEAIEDCGFDVPAKPPIMTFRATVLGMTCQSCVRSIQTALGGKAGIIDVQVSLAEERATIQFDSSVINQAEIVEAIEDCGFDIPKDTPDFASVTLDVEGMTCQSCVKSIKAALSNRAGIKNVEVSLEQNNATITFDESTITRKDIIEAIEDCGFDVPLEPVKHNPFEIQPISDKEDNGIVMETILSSSKGRRGSQATGSVASFEVRGMTCASCVSSIEKAVSIQPGIFSIKVSLLAERATVEYDPLVIEEEKIADLIRDAGFEANVIMQKQDDVIDLKVFGMTCASCVNSIERGLRNLPGVITASVNLMTESAKIQYNHQQIGVRAIVEAIEDLGFNALVSDQTANAQIESLGKIREIKEWRRALARSLVFAIPVFVIAMILPEFSFGRSLLDIRLLPGLYVFDLVQLVLTIPVQFGVGKRFFVSAYKSVRHGTPTMDVLVSLSTASAFFFSTISLLRSFLAGSDNHPSVFYDTSTMLITFIVLGRYLENLAKGKSSAALSKLMSLTPSTALMLVTDPKTGQVTAEKRIPTELIQLGDLVKIVPGDKIPADGVLHSGSSSVDESMVTGEVDAVMKKAGDTVIGGTVNGLGTFVLKATRVGSDTALSQIVKLVEDAQITKAPIQGFADVVAGYFVPTVIALGATTLVGWTLLVFILGVDHVPSMLRDEIQSEGNGNWFFVCLKLCISVIVVACPCALGLATPTAVMVGTGVGAEHGVLIKGGAVLENGQKVQKIVFDKTGTLTVGKLDVSSYVVGAESPVNAISMLVYTAAAENQSEHPLARAIVNKAKAVLGIEVLDTIATVENFNSTTGKGITCSISLDAAAVGRLNHHDEAIATAPATVVVGNKSWIQENAINIPEDYIMEMQALESKGDTCIFVAIDYQLTGYISLSDCVKPESARVVATLNAMGIDTAMVTGDNELTARSIAKQIGIREVHAGVSPNGKTLIVQRMQGERMMKKQHFLQRLTSSLFGRSNNTEKRTIVAMVGDGINDSPALVAADFGIALCSGTDIAMEAADVVLMRNDLTDVVGALHLSRTIFRRIRINLLWACIYNVVGIPLAMGIFLPWGFHLHPMMAGFAMAASSVSVVMSSLMLKWWKKPAMMEVDPNNFVIDMPATKKNDAKAEPFVTRIKSLFTRSQGYEELPTNADGSESPEAMFDLGSDEDDDHIQLIAPSSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJA6</accession>
    <name>A0A8H7PJA6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2175032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJA6"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="113"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2175032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="383" mass="42449" checksum="6E94BF197667E93D" modified="2022-01-19" version="1">MFRPVANRLSLNARASIYQIWRRSLVPSFVALRPITARQEYLLHTSSTPPLQHQPVTVPTFSSEDTVHIVNDKPEPSEPQSNPNGSYNYVVAASWHPKNRNTRKSKDNAEKIPYWKRNKVGKVDAGEDAFFHTNTRKGLAVGVADGVGGWAEVGVDPALFSWTLMNNCANIAKDLESINAHDILDNAFTELVDGRTVSAGSSTACILEMCKKTGYMTSCNLGDSAFILIRDEKIVFESPSQQHFFNCPYQLTVVPDNYPNRASYVTDLPKDGDRKSFFLRNGDLIVLATDGYFDNVYSQETVQLVNAHMAQLPAGANNADVLTHVRVLAKMLTDAARRLSLDPKRLSPWAKGARAHGGHYRGGKVDDITCIVTLVQQENNAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJE0</accession>
    <name>A0A8H7PJE0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_005897</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJE0"/>
    <dbReference type="OrthoDB" id="19981at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021013">
        <property type="entry name" value="ATPase_Vma12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11712">
        <property type="entry name" value="Vma12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2174835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="137" mass="15483" checksum="0462944BD657F3FB" modified="2022-01-19" version="1">MTVISKHAKMLQKQLFTQNKTNQSCTDNQRYWLHELLKGSTLYRPPTSRPPRNPELQARLDKIAVDNSNKEYAKMVKSAVVSEQDKVAFRIPQDEMQEIRGHLSAIINVLFSIIACFGAFYKMSGVISGDPGTVRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKB8</accession>
    <name>A0A8H7PKB8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED18</name>
        <name evidence="9" type="ORF">INT43_001225</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKB8"/>
    <dbReference type="OrthoDB" id="5348092at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019095">
        <property type="entry name" value="Mediator_Med18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09637">
        <property type="entry name" value="Med18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2175578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="219" mass="25012" checksum="3232EB207C596EAB" modified="2022-01-19" version="1">MSSGSYECLLHGILTTEEAKDSLLRRLVGMCGKDSQLDLFEHQIGFSPTVQTAAGPARNDDLLLRLHATISNEKQKSLKHREWYLVLQGYPEPQRGRTVTVRPVTQAKVGGDALRFVRSLCYTFAFEFARQGFVFAYQDNVRISVTRLYKLSKRWDVNSLQPFHDNEHQWLVEVTSIPVGQEQVNQMAEQLNKIRALLSGIVELESVDNRALQNKIHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKG7</accession>
    <name>A0A8H7PKG7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_001022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKG7"/>
    <dbReference type="OrthoDB" id="1939598at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="89"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2175375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="196" mass="21664" checksum="147B7554661CA750" modified="2022-01-19" version="1">MSISMLSMSESLSSNRNLGAYPTSHRAMAISSITSPPFSSASLSDKKHSEYRHIGSLLEHSPPPSLGASSPDSASNSSTGSPSPISLHERRQRNKAASAKYRQKKNQQHGEMRSIISHLTEENALLSRQVEELKRENQMVRATCDQLRGKIVASKMLKRMMKAENDEPIRTKKRRNNSQLLDDGASVGYPSDNDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PL82</accession>
    <name>A0A8H7PL82_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial distribution and morphology protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mitochondrial inheritance component MDM12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MDM12</name>
        <name evidence="12" type="ORF">INT43_005438</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion outer membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="9">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MDM12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PL82"/>
    <dbReference type="OrthoDB" id="3356905at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21672">
        <property type="entry name" value="SMP_Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03104">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027532">
        <property type="entry name" value="Mdm12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26544">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="1"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2176204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="456" mass="50444" checksum="C34679AF70F1B32C" modified="2022-01-19" version="1">MSLDVDWSKLDDSLAAKVRDFLNEHFKNITKPSFIGEVEVVGFDWGIEPPQIEITHIGEPFDEFYADDLEDEQPAPSETTEEIQENAASYLNASKTESVTGHSQWPTDLSENNSNPYFAAGSQIYGSGNNISNPNISISQHEIRNGFPMPSTPTFNAYLLNSFHRSPLVAPHHPFSSTPNLFSPTQSAPLSPTLSSTAPRHSGAIPPVNIESRHSAASVGNGLDSSLYRSDGLTNVGSALDLQDWIDDVEFPRQIGGTGSQGALDDALAAAVDESKAKLEQSKTESDFQVHFSITYKGDMAMTILTELRMNYPSVMFMSLPMQLRVTALEFEAVAVVAYLKGMNRICISMLEPEDLEADGVPTVTRDFGRFVLFSATSLYKLSTIWVAINLLRTMTHTSLIMSSLLRNVQIESVVGDEQKQVLKNVNKIERFIIDQLRKMLDDELVFPSYQCVQMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLC2</accession>
    <name>A0A8H7PLC2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nitrogen permease regulator 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_005498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLC2"/>
    <dbReference type="OrthoDB" id="338854at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2176264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="54546" checksum="468910136AAA288F" modified="2022-01-19" version="1">MESQGFPRIHSIFFVVFDNEKGPVVLHQVPEGTIVPHSPEANPSSSHPENDALFCTKPIIDFDAISEYIITKEQLNGRLVTICNNNYKVMGVPVRIKDHIRYIRNEYRFNLCFVFERDAETSSYEPIVQKIATVLEVLERECDFLTSEKTLPGAVTIQNVIEQMLEDLNSYCECQIPINASNTINLKLFPTYPNPTTVQNYHVPVCTVDLASMMSINWDITICKVIKHINGISSVRRIADKADVKIEWARQSIEHLLYYGCIILIDIYQFSNVYSIKPEVMQLLDEKSGLQEECIDYVTLPNHPAPSVQQLFKLYCGLQHGVTLRKLIDGNKDRVANIDLRRMVTFGVIKGLIYRVYKYPILFNLSTATAISPGNAPIKIIIQNTGNAIHPQLIPFLDGHHHYDEICTELRCSPKELDEQLGYNPDTLIKSNDETNPDATADVKPAGPAVDDNVNSTSLDSRELKRDSSNPDSWVVEFIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLS9</accession>
    <name>A0A8H7PLS9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Neurofibromin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_005591</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28245at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054071">
        <property type="entry name" value="PH_NF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF142">
        <property type="entry name" value="NEUROFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21877">
        <property type="entry name" value="PH_NF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="560"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="5">
        <location>
            <begin position="893"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2176357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1915" mass="215826" checksum="261269581D87350A" modified="2022-01-19" version="1" fragment="single">DILADGADIIEAVQSSVFMEATLLVSCASLNTDVCAQAIECIPFICAIGRTMDELEAYTHRELLIIENLSVYEAIAKSKESFLGRKAHQKRILECLRGMAQHTPGILGAWEEIWERWKILSQIDLDGYEGLMSNSDQNSSRLSRAADRRMNSPPFPHSGYGKPYQKMNLEERALQWQNYTGFLAALGGCLLTTTSKNKALDIWLFTGRKPIRSPRKADDYHGMIKRFIIELFNHLISDNIFMRETAKEALGRDLSPVLHAMLLEHMEVTLAQCFEDDGDVMCSPSYNLLIDQSITVLKLILDKINESSASLFAVNFSGLIHQFARYLNKLGTSQTALKMKIRMCNLCETLMQKKEYVTIRQEYLVRNRLLEIIVEWTSDFALKPDNKSVLTAAENSMNDKLFHDLDQACLKTIVSLLHQLPLQPLESVQEGQLGQAKSRMFYKYFTFFLKLLNRCKNIEAIENPKDLEPLKNFTILAMSNLLSANVDAGLKYSLTMGYHEDTRTRAAFMQVLTNILKQGTEFDTLAEDFEEERNERLVKMLADSDMSITLSLCEVCPAQQVDEVAEVLMACFESRNKNMELLKQLIAREVDSTEQEATLFRSTNITTRMISLFTQNACTDYLHMTLQPALEAFNEIPPEKATWELDPEKVGKEEDIERNKENVIRATEMLLTPICESVKKAPSIFREVLSMIVQAVQQRFPEAKYTAAGGIVFLRFFCPAILTPEGLGMPKRCSPKSKEIRKLLVQATKVIQNLANNVLFGAKETHMIVLNDYLTTNIYRVTNFLRDISKAPSNSEKVPPAPSKLDKTTHIKLHRLLFNNLEKMSRYLSTHKSNKDSNTAEALELKKMFDSLSNLLFQFDKPAELPRDDTPVFRQHSPRPNEHIYSDLIRRNENRNLDALLAKNIFYEGGVSKAGRPVFYFVTRRIDGENIDFELLLYYMMKQMTRLPSRPFEIVFDNTQLNSKHEFPGQWLNQVFVMMLQDIVDRIATLYIYNPSTYSRSYYKKFSRGLVGKLAKKTIAMTSLAELHEYIAPGKVRLPQTTVELDTQSSVVFYPVNRLSSNNLTTTVTIKVGLTHIQIMTARKQELVMGFQGVINDVFHISDVDVTSTVNPRFDESNEFTLKIDSLKASVAFVTPRKAALVALIGHNKKRFNLAKPTTVTERIIRPEDVPGRLLNMALLNIGSDDPDLRLAAYNLLYSLSLSFRFDISNRLLNSKDHCIPANSTSFIVGISENLAVTEAHLTLEFLNECFVGFNKSSEPLRQLCLEYMAPWLRNLGNFARNSPDGKSDNVIKTKEVIRLLIDLTVTRVDIYRLVQDKIWKTVGQVDDVINLVLDTFVQFSVEHGIGSPQAETMADTLVTLSNVGVKGKIIAHLRKVIQRTSFQYSKTLIEHPAWIEIATLVRFTLMLTFHSSSPIKPYLADLMYIVTLLVATGPTVIRTSIHGMVVNILQLISTETPLNEGHIKKLHLLANDISDSRNRVLYGIVEENVNPFTISRDTLTDVSEPINLGSLEVIVKTLIEAMSLGASSIDTSNTWRARWMGLATSTAFQFNPAIQPRAFIVIGCLAQDEVDDDLVYQILVALRGALQFHTDADSNLLISILMCCKNIAQNMPPTSRYLLPLFWIAVALIEINDPDIFSASTELLTAIVQILDHHRLLYEDESLIDALLQAREPFAKAADELDMKSEVNFNTHFSFAVVGTLLKGVKHADTRPAVLRALSVFLEVERKSSFDQRTVNPDMLAYAVSLMPLAARDGNLPAILRLAGIDDREIDRAGIFERLDIPDNTTALLMVSLLVNMLGLPDKDVDRSFIYGFLAEAAGAIPEVFGLIYDTLLPKMNQLVLSSQDTDLLESVHMIMLTACSEPAIQQARSQPSQKSLLNELQFAALADPTLGATKYDLVNSAKLASALVESIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLX8</accession>
    <name>A0A8H7PLX8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_005570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLX8"/>
    <dbReference type="OrthoDB" id="411017at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF19">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2176336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="298" mass="33920" checksum="A46DD41DEB1A086F" modified="2022-01-19" version="1">MTITTELQNAHTLTPPLTPPLLALKDANATIKSPPSKPPVDILRKVLTITDGRDKALKLIQYFIKIILHHGLISKKRSIYASLAALASNFSTTRKIIRLGHIIEPAAELYNIAYTSPKKLPKTSKERISSYLRILGLVFGLGNDLADDIFCLSKINVLPASWAKKAEPWSYRCWFSAILIDSHFMIRDILVQKARMSEWQRVHALSKSKELEGNHDRNTLYDELCWINNSDRANLVQEWKDMEDKLFWLRLSLVKTMMDGGFCGYDLFHCQFSAGFQAWTGFVSGVLSAYKLWCKNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLZ1</accession>
    <name>A0A8H7PLZ1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_005378</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLZ1"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000001">
        <property type="entry name" value="Nucleolar GTP-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="10">
        <location>
            <begin position="205"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="591"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="601"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="635"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2176145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="697" mass="78583" checksum="EF377FF0295B26FA" modified="2022-01-19" version="1">MGKLKKERNRVANSGGNAEKAGNLRVKGENFYRDAKKVKFVNMLKGGTAIRNSKGEIVREAEFQSKETPTARVAPNRKWFGNTRVIGQKALENFRESLGAKVNDPYQMLLRQNKLPMSLLQDPTKQGRMHILDTESFTRTFGNKAQRKKPKVNISSLEEMVERVDDVNESYAPGKDAKLLVNQVVDFTDEARGWYLQAGQSKRIWNELYKVIDSSDVVIHVLDARDPVGTRCKNVEKFIQKEAPHKHLIFVLNKCDLVPTWVTARWVKHLSKDHPTLAFHASINNSFGKGSLIQLLRQFSGLHSDKKQISVGFIGYPNTGKSSIINTLKAKKVCTVAPIPGETKVWQYITLMKRIYLIDCPGIVPPNSEDTETDIILKGVVRVENIPTPEDCIPVILDRVRSEYLQRTYETKDWKDPTDFMEQIARRTGKLLKGGEPDLHNVSVMILNDWLRGKIPFFTPPPSSDGTQETAADAARWGNKDAATKAANAAAAKAAHNERQTAERKAGRVGVDQLFRKIHVVTDFLPDDLENDKDLKEEEREKEQQMIANKKEMLALAEQRKKSRKAAKEAASVAEEITDWDEVFGSVVGEEGPLVEAPVIDGEDSELEVSEDEDAKDSGNVEDETEGPKTRSKRPAFEVKDIEGDADEDDRKTTKEKRMTTNKRKVGVHYYETANVKNRNRNKVKPDGGANKKKRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMN0</accession>
    <name>A0A8H7PMN0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">INT43_005473</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMN0"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000705">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="18">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="488"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="306"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="391"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG2176239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="765" mass="85640" checksum="376C3A8545F0C6F0" modified="2022-01-19" version="1">MSETASFEDPSISLSRQKEIASAPVFGTKKSVLRRPSFHSLHHSYARKSVASLNQVRRAHESWTPKVLRSPKSNPALAHMASSESSPHLPKMYNTDWTMAGVDDEISPSMYRVANNNTSDTETLRESFYTTGCESVPSDETIASRNSIASELQTVDVNEIGTGNFVASEGLRSRDRNSFRGVIERMVIGFNELMSKDQQANRAIDIGTPYNAKHITHVGFDAKSGQFTGLPPDWQILLKHSGITEQEQQQHPQAVLDAIGFYKDSQRHQEAIWNKLTTAESSHATYRYADSLYSSSNYSIGSNVSYPERRFESPRPPPSPPSNSVHSIRLQKMNAITKQEKSSIESSKRPSEQTHSLPPTPKQSQISEANITPIVEDIEPSSPPRPKHKEKAPLRSPKKELKPGKNVYEVDRIQQHIADRSSESKPLKKPDIEPIRSPKSKGEEKVVVNASASRGSKRRTARKPSMPDEEVLARLKQICKDEDPTTIYTNMVKIGQGASGGVYTAYPSNSTTPVAIKQMNLQKQPKKELIINEILIMKDSRHSNIVNFIDSYLWHGDLWVIMEYMEGGSLTDVVTCNMMMEGQIAAVCKEVLQGLIHLHTKGVIHRDIKSDNILLSLQGNIKLTDFGFCAQLNEQRSKRTTMVGTPYWMAPEVVTRKEYGPKVDVWSLGIMTIEMVDGEPPYLNENPLRALYLIATTGTPQLQHPEALSDTLRDFLNKCLEVDSEKRPLASEIIDHPFIKRAEPVRSLTPLINAARKANRSNSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PN23</accession>
    <name>A0A8H7PN23_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_007896</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PN23"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20346">
        <property type="entry name" value="BRcat_RBR_ANKIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
        <property type="entry name" value="Rcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000007">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="116"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="120"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2177239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="502" mass="58775" checksum="9EA1D1DE94AB25B7" modified="2022-01-19" version="1">MPPAGDELEYFEDGEDLNFDGVLAEKHRKKLYQVDYTVQSAKHLMGSQDKEVGQVAVILGMPKEHAATLLRHYRWNKEKLIERYMDNPDSVLRIAGVVTEHVRRIIPAREISSPEHPFSCDICCDDDEDSETVAVSCNHRFCRTCYEHYLRQKIKEEGESRKIECPQDGCKIVVDEKTVEQVVDKNTHLRYRELLNRTYVDDNDHLRWCPAPNCEFAVECHIPSTSLTTIVPTVECECGHQFCFGCGLPDHQPAICPLVKKWQKKCEDDSETANWISAHTKECPKCHSTIEKNGGCNHMTCRKCKYEFCWVCMGPWSEHGTSWYNCNRYDEKSSHEARDSQTQSRASLERYLHYYNRFANHQQSAKLDQDLYRKTEKKMEEMQQTSDLSWIEVQFLKKAVDTLTQCRMTLKWTYAFAFYLSRTNETVIFEVCDVTDNQKDLEMATEYLSELLEKPLEREKIAELRQNVLDKTVYVKQRREILLEDTAKGLLENRWSFFVDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PN60</accession>
    <name>A0A8H7PN60_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_007763</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PN60"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000011">
        <property type="entry name" value="COP9 signalosome complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="257"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2177107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="446" mass="52267" checksum="9484424B9C48EC1E" modified="2022-01-19" version="1">MSDDDDFMMEDDEEYDFDYEDDEQEEPDVDLENKYYSAKARKEDDSEAAIQEFQDVVDTEEEKGDWGFKALKQMVKLSFQLGRYEDVSIPTIRYYEELLTYTKSAVTRNYSEKSINNILDYVSSSDDMAFMEKFYHTTLNSLMDSKNDRLWVKTNLKLAKLWLDRQEYSRLNKILRQLHTSCQKDDGTDDQRKGTHLLEIFALEIQMYTETKNNKKLKEVYQQCLRVKSAIPHPRIMGVIRECGGKMHMGEKSWDQAQTDFFESFKNYDEAGSSQRIQVLKYLVLANMLTESQINPFDSQETKPYKNDPQIVAMTNLVSAYQKKEIREFEKILKENHSAIMGDSFIRTYIDDVLKNIRTQVLIRLIKPYTRIEIPFISKQLNIPVEDVEELLVTLILDKKIAGRIDQIQQRLEIEKQSSDTNRYAAMNEWSSNVASVCKSVLSKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PN61</accession>
    <name>A0A8H7PN61_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_007547</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PN61"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000374">
        <property type="entry name" value="3-oxoacyl-(Acyl-carrier-protein) reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="11"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2176893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="256" mass="27151" checksum="AD32C5637CD1B433" modified="2022-01-19" version="1">MTPQQQPLKGKVAIVTGGSRGIGEAIVKHLASKGADLVINYTSSSSESLAKDLIEQVKTHGVKAVSVQADIGSLDGPKKIVNAAVEAFGKIDIIVNNGAIADFQPLTDTTVELYEKTHNVNVRGPLFLVKESLPHLQEYGRIINISSIAARLGYPGSSVYASSKAALESLSRVWATELAEKNVTSNSVNPGPVLTDMAKSQGQDFIDGLQKSTERAAFHRFGTVEEIANIVGFLAGPESQWVTGDVLSGNGGYLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPC5</accession>
    <name>A0A8H7PPC5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPC5"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="253" mass="28684" checksum="3C4D560F527FF7FE" modified="2022-01-19" version="1" fragment="single">FSDIAAPFSSIQFNSLHQPQSPTISYSKPSPPTKPIRRKLSIPQQQQPDYAALTGPQSPSDQDRPPSSAFLNRLAESMRDKRSLLEVRKDEFMSETLPEWKVRSAEFSSMAKETSMEWGKRGRDTIDRWKKDRMSDSIPATSPSYLSTFPSLSASEPSSPRGSVDELHIFGCSLESAVDMTRLSENDHVPGIIRRCIDYLDEYGWLHHHCAPRKFTTPEKLIFPAIPAQALMKLVYIGKWLQMTLAIRCHTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPV1</accession>
    <name>A0A8H7PPV1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Polysaccharide lyase family 8 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_007747</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide lyase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPV1"/>
    <dbReference type="OrthoDB" id="5980780at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016837">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on polysaccharides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.10">
        <property type="entry name" value="Polysaccharide lyase family 8-like, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038970">
        <property type="entry name" value="Lyase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011071">
        <property type="entry name" value="Lyase_8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012970">
        <property type="entry name" value="Lyase_8_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004103">
        <property type="entry name" value="Lyase_8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003159">
        <property type="entry name" value="Lyase_8_central_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38481">
        <property type="entry name" value="HYALURONATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38481:SF1">
        <property type="entry name" value="HYALURONATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02278">
        <property type="entry name" value="Lyase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02884">
        <property type="entry name" value="Lyase_8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08124">
        <property type="entry name" value="Lyase_8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49863">
        <property type="entry name" value="Hyaluronate lyase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034199901" description="Polysaccharide lyase family 8 protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide lyase 8 N-terminal alpha-helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide lyase family 8 central" evidence="5">
        <location>
            <begin position="375"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide lyase family 8 C-terminal" evidence="6">
        <location>
            <begin position="647"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2177091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="783" mass="85252" checksum="A41DB5730D8EA597" modified="2022-01-19" version="1">MVAFKPILLALVGALGMSVVYGAPAVNGSLATVQHTFMQAQVNMTSTSSSKKWASALSASGSWSDIDYTSGCPARRASWPAVSHWSRLASMAISYYNNPSNNSALLSKIQLGMDYWFDNDYTSLDCVDLGGLTNATCPCGTPGLWNTNWYDQVIGVAKPASVACLFVQKDLSSNATDGCTRIMTRSWSRIDTWIYGLGQVTGANTLDVSSVGLSLALFTANETLMQEVFSHANGQVITLPDPNDGLKTDGSFFQHDGVLYNGNYGMVFANDFLLFAAAAVGTPYEATSSQKEVFTQLLEGTEWMSFYDSVANVLRWEYSSLGRMVSMSSYSPFDVNINQYPNGTSTWTEYPSISASAKRLMTTGKSANPGNLNGNKMFWDADYMIMRRSNYVVSLKMFSSRIRNTECVNLQNIKGYHLSDGLVYTYLTGNEYVDIFPTWDWYLLPGTTAAYGANPLTCDTASVFGNNSFVGGVSDGNIGVAAMQYTDPTSVSANTTEWNKGWFFFDNQYVVVGNNIRTNTNDDFYSVLDQRKLNGSVYTSADSKVPVPTNSTTNYTNPQWLWHDNIGYVFLNNTAPTLSVSPSQQSGNWSSIAIDTNVVTMDVFKSYITHSNSTASQPSSLAYIVDIGVSYSQFQRQAPLLKATIQLLANNQQVSSVLYLSDLTLGSIFWQATSLSLPTSSPFSLQLSKGKQHSLFSLSVDQPSIVLMQPNIHNGTVSVSVSDPTQSQTTLNLRVSNAFLKCSKASSTGFSCKNKGGVLQIRVTLPSEQMAGSTISGSLKFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPX7</accession>
    <name>A0A8H7PPX7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_003022</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPX7"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF91">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="549"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="605"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="667"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2177775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="678" mass="76593" checksum="5027300FCDB6F48B" modified="2022-01-19" version="1" fragment="single">MQHVNGVPVYNSDPNVLYDGLKNCKPTWYSAQGGVYRCRQQMHPNTLIAIKKYYVEECYEDPDAFIMPRDLVENEIYAMTLCAPHVNVLKLHSVHLFQECIYLIMPLCTGGSLQEYVFQNRVSVGQMVYILQGLVNGLHEIHRHGYIHRDIKCDNIFLTKETNEIVIGDFGVVSIKATADSVAEEAGVVLFWAPESIEGRIVDNKIDIWALGIVIMEILNGGKAPYEDEECSEETIKEIILATGRPKYPDGLPPLLVDFMDRCLEVDSQHRASTDELLQHPFLTECESEYLFPSYPLHNHDVDDYSSTMSEDMVVPVADSDIILEQPNMDDIMSGTTADQAFITENEEAGMLRIKDRLRTLELLTEKESSKVDRPVDPHTTNYPSEQPLEVDHDTIAIPSIIDKSNQHSIPEEDDQPPPQQLQTHIPRKRSYLARSSILLSGVDNVQGGAMHRLKELKDIHPVQQAYDVFHRRTFMCKNYRDQGSRLPLFIAAVTPKEQLPTAPVSPPKAKEIKRVKSMMVSPKEERKSSANVRRAYSVANFSDKENKPIVRSGTTLQAHPPTVVKPQTKRISQIDPRKSLASTTRNNQKAAESDTKVPEKTLRRVSTSVDVRSHKSAANTKSSDTKLYKSTSGIDNRDTRARKLTSNVDNKDTARARRTSTNTRAELAKSLKQETRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQ36</accession>
    <name>A0A8H7PQ36_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">External alternative NADH-ubiquinone oxidoreductase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQ36"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF17">
        <property type="entry name" value="NADH DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="6">
        <location>
            <begin position="50"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2177853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="117" mass="13387" checksum="4C5BEABEB95E0427" modified="2022-01-19" version="1">MGDCATIKDHDLPATAQVAKQKAMYLGEVFNKCAKNGQDTQIPEFNFKNRGSMAYIGSWEAVVDMTPVHQKATEGGHFAWFFWRSAYLSMSVSLRNKIQIPMFWFLTWVAGRDITRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQF7</accession>
    <name>A0A8H7PQF7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein JTB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQF7"/>
    <dbReference type="OrthoDB" id="2245086at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008657">
        <property type="entry name" value="JTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13041">
        <property type="entry name" value="JTB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13041:SF3">
        <property type="entry name" value="PROTEIN JTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05439">
        <property type="entry name" value="JTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034171415" description="Protein JTB" evidence="2">
        <location>
            <begin position="29"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="16946" checksum="95DB8E2621A9DF1B" modified="2022-01-19" version="1">MRRTLLQHTAIFILLVFFLSAAAALGNAQSNGPSLQSRQLSSDMYTCSVVGECKVCTDLEKKTQPYCKEYGNKQAISCKYNEDITGMPDALPLFQACPRVRWVERRHYHVFVVSNVVVSMLAVGVFLWRHRKLTGEQYRRMAQRIGISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRF8</accession>
    <name>A0A8H7PRF8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_003133</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRF8"/>
    <dbReference type="OrthoDB" id="429955at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052221">
        <property type="entry name" value="SLC35F_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233">
        <property type="entry name" value="DUF914-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2177886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="183" mass="20589" checksum="776754D6AC18B45D" modified="2022-01-19" version="1">MLWLYFNVNVPPLQNLLNYVLLFVVYTAVHIRKHGIEAWKLMLRERAWKYTLFAMADLQGQLHLFGVFTHARYSKTQYTGVVLCMSGLALLIYGDYVNNRLETGLSLKASLHIAPDKEEIKQSITCIDNHSWIGDLSCVSTLAGATLYAIANLIEEHLVAENAIEEVLGQLGMWGTIMCSLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRH6</accession>
    <name>A0A8H7PRH6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRH6"/>
    <dbReference type="OrthoDB" id="10050400at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040201">
        <property type="entry name" value="Mrg3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142:SF1">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="263"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="422" mass="46964" checksum="27433AA58D2601F3" modified="2022-01-19" version="1">MNSIRRASLQCLRSSRVPAGGAAIRPMTRRSVLQSVKPHYQSFATYTNQPSRSIRIPPLPVALTVFGFGCLGMGLYQYFWSDIQKYPVPVRQALRKALYYENYGNDPSLAIDYYKQALEIALESEQLENNSPHVTGIMIQYGTLLETEGKTKQARDVLTTCLGYLLNLSGADVAEKVTSIDLSSISLSGTDRTKVLGIAQKLGDLSVELKDDEAAEKWFSWSVEQMFKSTLPIASDSGMALEPKEKLFNAENMPKWLTKNDVGAAMEALAAFYAEKGKYQFALPLYLRALSLYPDLKQSCHACVLMCNVAEVFAGMGQFQEAIKWAEDGIEIAKNPNTGTKKGDDRTICDEALGVLFYNIGMAYEQSGNPQAAMIYYNRCRKHATELKLVACKREADVALKRLKLDHKTQGSEQGSMFDQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRH9</accession>
    <name>A0A8H7PRH9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRH9"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="224" mass="24085" checksum="38E5576EDDF4891E" modified="2022-01-19" version="1">MSHLEVQKALFSIFVVRRETLACPTCAEVGSLMGVEPSPTSAAAVLCSSCSAPTTMEELQVRLPEGKTETRENTSLPTTDNTSEVIAVLRAELKTLQEALAQMTAMYELLMAQVIGDRGKKGNISFPLPAPTKLPSQTLPRKQQTPRKPASATPLHKFTFQAPTLVPTSVSVTNPPSATWAERTKVHLPARKKPSTARSIAADVRVFKEDNGPMSTSTSRATVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRQ7</accession>
    <name>A0A8H7PRQ7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_001832</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRQ7"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22701">
        <property type="entry name" value="FHA_FKH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000030">
        <property type="entry name" value="Forkhead box protein K2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="58"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="9">
        <location>
            <begin position="202"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="202"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="165"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="287"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="479"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="479"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2178983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="537" mass="57091" checksum="127E7C0D7C5E9A04" modified="2022-01-19" version="1">MTAADSNIAVATTSTEVPDAAEPASSQPSTSNLDSGPVQAYAKLEGDEFCYYIRTLQVTLGRKGSKNENVDIPLGTTKSVSRQHARLFYNFTTQRFEMMVFGKNGAFVNEHFVEKGVTVPLENRTKIQIGEVSFLFLLPRMDIEEPPQAESLGYIATPQQLENKSFGQKSSVNGNDNSKDDSAASDDMNDVDGNQYNNKDTKPPYSYASLIAQAINSTVSKKMTLNGIYNYITTHYPYYQMAQNGWQNSIRHNLSLNKAFVKVPRGDSEPGKGAFWTIDSAAESQFTNGVYKRNRRTGSKTPTPSNYEANPSKKKIKREETESEEQATTTKKSQSETLASVTTTNTSSPTTKSAITAATSTAPASKAATSNSTAAPAINITSAYPTPQSIQAQLQVQLQNTIRQHLLDPVRYPLPASIAQLLPQAIAQLPPQLASQLSATLQSALRQGSAAANANKSSTPAATTTATTTATMAATTAPATTATTTATTTNSTGSAGVAVKASSPSTTTADSTSSAVADSASANTSDPAKEDSESKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRW5</accession>
    <name>A0A8H7PRW5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PROP1-like PPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_001997</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRW5"/>
    <dbReference type="OrthoDB" id="411857at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051114">
        <property type="entry name" value="Mito_RNA_Proc_CCM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033443">
        <property type="entry name" value="PROP1-like_PPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934:SF6">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN PET309, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17177">
        <property type="entry name" value="PPR_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PROP1-like PPR" evidence="4">
        <location>
            <begin position="307"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="369"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="406"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="831"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="866"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="902"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2179147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1053" mass="118512" checksum="17507A554C4BF035" modified="2022-01-19" version="1">MYASKGTANIINTVTRQGLLSKQLTASRPNTLLPAPTRSSAKLYATGRATFSANRQQQQQQDNSSQQANSLNPIQAWTGNNSAAIFQKYAGVRYNHSAAAATDSQQESASSSGQEATKKGNARILEAKRNRDLRKVEVEFKRMKDSGVELTSQTYTLVLDSLASLRRPGQPPQRLLAVYQEMIENGHRPSAYTYMILIHTLCKRDVEVQKTLMMINAKSSRTGDIPSNFESLQGENNAQKALAIFEAAVTDNRYQDFDTEVFNRLLRSLSQYGNTQDGLYVFEHLEKARSAEPNARTFAALITLYGKAGDIQGALECFNEYKTVRGQMGQHNPGFVYSALVDAYIKCGDSDAARKIIEVDSVNDQVETSVLTWNALMRDYCDKKNLDSAFDVLSKLKNDTSLPDPTAATFGPLLTALCDLNMTEQAQNIYDEMIKTDVSKSYNNLASYAHLLLESKQYERLQTVISDMSKQGLVPSDDLAEKFVLGLADNGNVSEAIDNLRKLYGDLSAKAFVKVTDGINQTAMHLATKVDNNLAQILEILEIVHKYGVRATVPVSEKICTAFNQVRKDPAAWDSLKQHIGVTQHFLMIEALFNSHHLSHEEFRNLAIDMTKAMIEVNIQPNTGLYARVGSRLVKHGDTEGEKMWQDFFEPYLKDPTPQSDPFRTASKTSDEKLMFRTTKSDLLTGKAMKAAVQGNLPECLDVLQNQIIAQKMVPTIEAVRDIIQIVGRDINPEASRKVYDVVSVAFDTMKDKAMRKRAHASTLSSLMNVHLQAKQYEAGRDYYKKLRNLDQNPDGNGYGLLMNSLPDNESTSQQVLNYYNELLVSNVQPTVYLYNVLISKLGKAHNLKQVIQAHKDMKKYMISPTAVTYNALISAFTRCGAEKTALETFHEMAKHAKFKPTVATYNNMIQFYVRHESNREKALEFFERARSSNVKPSSYTYRLLMEAYSNIVPYDMPTAYKMLNDMKKDDIKPEPRHYATLIYSYGLLQRDVQSAERVYEQVKKEGLELDDSVYRAMYETYVANNDMEQADKLKQFLADEPPILTPPKGSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PS49</accession>
    <name>A0A8H7PS49_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Formin GTPase-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PS49"/>
    <dbReference type="OrthoDB" id="2360425at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formin GTPase-binding" evidence="1">
        <location>
            <begin position="74"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="643" mass="73222" checksum="166BD01043E5AB97" modified="2022-01-19" version="1">MSTSVIHGYVPANIRTSTTETKRPIIGKVSSFFHRKSVASNESAMNHSTFHPGWDDNDIKTRTFDDLLSNCQNEQSMENIDEAFDKLIKEYGLPSTLKPNLETLTLAQKKTLLDSYRLSHADRVKPANSGFSTDRMKMLRPLSILTKDAGIKQHTRNRRQRANSKMSLSPDQAAHMLHISNINTIDIQQLTEIHILLKSTVTSWSIDFLKIGGYGGLASQLQQLKSLSKRTPQNAKVLQMITRCIKALMTHEFGIQKLLTEPTCLRLIRDLLFSPTASNRKSLYAFDIQTRSLMLDVLCNLTAIQTSGDASEYVHGWDLLLSLLQDTNHDKERLAEEERRKSRIPFPTANETHVAKNKAPCRFTSWMRELMFILDKYIEPISFLAGALDFRFESAYRQLRVSHEKGAPPNLETDGGSVMVDEGVVEYLITHLRLICTVITNPPTCYKKEYAATDQELVRLEFMSSGFERVSRGLRSCPHPTLLHSYINYLAPLVTPWATLNPVELPHDPEQHVYEESLVDEMIEPSPPVSIKGLTDPPATEQSKAFAKAEISRVNRQDKNNEIKSIKLNSIRVSDKEEFVQWQEEIRTMDTSSSEELSIDSPPRSHVWLAKAELDAEMDYYEQDDYDDIIEQPVTTYWMKGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSJ4</accession>
    <name>A0A8H7PSJ4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_001948</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSJ4"/>
    <dbReference type="OrthoDB" id="24683at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000299">
        <property type="entry name" value="Zinc finger protein 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="76"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2179098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="130" mass="14930" checksum="3E33283EF4914681" modified="2022-01-19" version="1">MGRLRRSRTHHGIRDNSRKFRTRAYTKDLDQIHDDLKGENFAKLKSQPIDADKTGLGQHYCVHCARYFPNDDQLQQHEKTKLHKRRVKKTLEEPYTQKEADAAAGMGAADNGKRGGSSHQSRNAEDVKMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTH6</accession>
    <name>A0A8H7PTH6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_003804</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTH6"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005409">
        <property type="entry name" value="Synaptobrevin_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="28"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2180017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="158" mass="17604" checksum="02D6E06D85A6C265" modified="2022-01-19" version="1" fragment="single">SEPYDPYIPNSQRPGGANESAGGAGNAKTARVQQQVDEVVNIMQDNIDKVMQRGERLDDLRGKTGMYITHSGRRLVWGWSQKATALCAHNIVFWTNFATLPVYIGQDLQATAGHFRRGANQVRKRMWWKDLKWKIIIGVTVLVILAIIIGSIVGTQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTT7</accession>
    <name>A0A8H7PTT7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="4">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="4">MTA phosphorylase</shortName>
            <shortName evidence="4">MTAP</shortName>
            <shortName evidence="4">MTAPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_003768</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTT7"/>
    <dbReference type="OrthoDB" id="431409at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000008">
        <property type="entry name" value="S-methyl-5'-thioadenosine phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679:SF2">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 4" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="58"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="91"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="216"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2179981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="299" mass="32947" checksum="66DB2B70A49E4254" modified="2022-01-19" version="1">MVEQKDVPIAVIGGSGLYNLDNLEVIEEINPETPWGFPSDKIIIARSPSGCKIAFLARHGRGHYLTPSEVPSRANIAALKHIGVKAILAFSAVGSLREEIPPCDFVLPDQVIDRTKGVRPSTFFGEGLVAHAMFADPFHAGLADLVYAQRHVLEHGGKVHKNKTAVCMEGPAFSTRAESHMYRSWGADIINMSALPEAKLAREAEIDYQMICMSTDYDCWRVEEEAVTVETVMQNMVNNSFNAKKLLLAVLPSLEEAVANNTLLPNYQGSMKFSGMTASEKRNSETVKKLEYLLPGYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTU7</accession>
    <name>A0A8H7PTU7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTU7"/>
    <dbReference type="OrthoDB" id="2420495at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="153"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="405"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2179996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="470" mass="54108" checksum="6B99A818782F6CC0" modified="2022-01-19" version="1">MIGHTPRHFANKRKPSSEPTPEKSVIKLAIFLDLTRPEPNRLAQYAKILEKQYRCLSNTTSNLEEELQQLKQVLEQDNDKLENERWEVLAELEMIKHNMPHLSSENHLTTLETQGLDERGSEESEKQGCTQLDELQERIIQSCRAQLASEIELEAQNGAIKALEKDLQKVNGLPQILPILRSSIKDCEQAVKKHRDTVSNLEDTRLLSVIKDYTKQQLRTSASEREMKKIVHKENKHDAYDEVIDVLLEQAAIEQLFLYIMELEEEKLKLVTDHQEALLLDNKVAVETADALQYQQVRECTKKTEQMLLDNLEKILNFKHSNDIDILENLEGGGSNTPITIVNRLEKLQLDDRAARNRTEASITSMNKLMVDSYTAVEKAEGYASLYYKNQDSNGLTPAAIIQTQAQLETLVEVLQSEIQHYQKVSIDRLLSNIITVNSELAEKKRRFALFWTDQQQFEQEFGRMRSSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUQ8</accession>
    <name>A0A8H7PUQ8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_008494</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FRG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUQ8"/>
    <dbReference type="OrthoDB" id="5539371at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23339">
        <property type="entry name" value="beta-trefoil_FSCN_fungal_FRG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010414">
        <property type="entry name" value="FRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928">
        <property type="entry name" value="FRG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928:SF0">
        <property type="entry name" value="FSHD REGION GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06229">
        <property type="entry name" value="FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="245"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2180914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="285" mass="31874" checksum="E0094BF7AB8D3EF2" modified="2022-01-19" version="1">MVSDPPKKGKLTFKGDKENKKKKKRKADSEDRSHDKESSSEGWVLCDQLDDLVGPLFITHPSDPAICLTVNDLELLVPYPIPNLYDESPAPTITNQVFIGARVVGSSSAFTLKSSLGKYLSSDKFGVVSIDREAVSMIEEWKPTFTDGGVGFQNAYDKFLMVDEIAGGGNTLPVHAEKQQYDSDSGLFFSGFKIRADAESLGFCETFRVYCQARFKRKAKMSKKEVVDASGVELDNIKKFQSWGSSRHMGTEQDMRELKRAKKQGNLSETLLDRRSKMKSDRNCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PV27</accession>
    <name>A0A8H7PV27_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PV27"/>
    <dbReference type="OrthoDB" id="2281372at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034979764" description="LysM domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="27"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2180285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="218" mass="21357" checksum="4AB0DD4E49037918" modified="2022-01-19" version="1">MKLLSLIALSSFAATAFANGPAPGCLQTYTVKPTDGCESIAASFSLTPDEFYNMNPGLHHAGDHVSVVDILHSDGSTQVINCVLPIIQKTNTALRQSCYCVCMKKPCAQAKDATTPSASVTSAAPSVKSVVTTPAASSMKSASVAASVVPSAMSSAVSGSASMPATGSAAASSGNATSAGASASTSPSAASSASSTEKLASSVAVIALLAGAASVFAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVP6</accession>
    <name>A0A8H7PVP6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-glucosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVP6"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF53">
        <property type="entry name" value="BETA-1,4-GLUCOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2181182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="62502" checksum="421360E810B0F72E" modified="2022-01-19" version="1">MFTPNKTTLEELWDQIEYINPVQVAAKSNLTNSTEFVLPSDPTHDMPTHPYEETKYLKFPKDFKYGVSSSAPQSEGAVKEDGRGPTIWDYIPHLFPPSVEPTIDIVADFYHRYKNDISRVKAMGINSYSLTIAWSRIYPLGTGQANEVGLEFYDRVIDELLRNNIEPMVSLLHFDTPFALLAQYGDFMSPKIVADFNNYAETVFRRYGDRVKRWITINEPRTYCKAATYFPYDRAYPTGINAQNAEWHCIHNILVAHGTAVQTYRRLIKEKVIVSGQIGVKNEFAKPAPYTDSKEDKEAADRVADFLLGIVAKPIFVDGDYPILCKETLGDFLPPMTTEEQKLLKGSADFYIQNLYDVPRAKAAPNGIEACVSNRSDPLWPVCRDERIQYVSTVPDGWSNGQPSAPITPTFSNTWFAIRDQLKYLAKTYPSTGGIYIGEFGWPELLERKRDELYQIVSDYDREAYYLDYLHAFLLSVNEDDVNLKGVFAWAAFDDYEWIIGTEIKLGLQYVNFTDPALPRSYKRSFYSYSNFMRQHLRHGDFNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PW25</accession>
    <name>A0A8H7PW25_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_008478</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PW25"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034305217" description="Sodium/calcium exchanger membrane region domain-containing protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="632"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="655"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="687"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="712"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="755"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="795"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="823"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="8"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="691"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="361"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="443"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="587"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="452"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2180898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="847" mass="93679" checksum="CC51C9F5527C0A3E" modified="2022-01-19" version="1">MMCAKFAFLAYLFAAIGVVASDFFSPNLQTIASLLHLSESLAGVTFLAFGNASPDLFTTFSALNSGSGSLAVGELVGAAFFIVTVVAGGMAIIHPFRAKKVVFLRDVTFFTGAVAIVGWISYDQKIHLYEAIGLILYYLLYVISVVGTTWWKNRRRVKVVIEREPIEEAISSSTPPTERTPLIRKLSSIAEACSKAPRVVIIEPRDEEFDDDEEMRDHPGHLGHIMRPVSPQMMRRISLRIDTENLPISDGLHAPTVTTATRAYRPPLTPRVGIRPSIFGAIEFRNALQAAQHANEQQLKLNFDDSRHRREQSMPANMFAQQRSATSPSDLESQTFSQKRVIKRKRPSDVADMVIASKKSFKPTLSPTSSDSNGAATDYFQRRQSESEELPPWMQGDSQYTMVNTENNSPLMGIPPDMDIPPKVDMPPNYTLPLPVILGQDKLLRTSPPHSPSLSPKSPDTTSRASSPRPSTFVSSRSPTPTSPSIRSVISEIENHPVKSSTSNIKTTWIVKQFQSKWLSFAKTHRQLYVIMQEVSTTLFPTLQNWDVKSISNIGSSILAVPIVFLLRITLPVIEDDSVRVDDMMVPINPDDNESSETSVISESSNLERRDSHDGFEPTAIEEKLDAIWSRWLLIVQAICAPTFIAVLLRVNDMILWDKVFGSLIFGICLAITLLMSTTSNKCPKWYKILSFAGFIVSLSWISFIANEVVGLLQVIGLILDISGAILGLTIFAMGNSLGDLVANMSMAKMGLPNMAITACYAGPLLNLVLGLGISATYNVWVTGESYSLEVGPTIIVSSVGLMMVLLSAIIITYFNRYKIEGWIGWTWISFYVLITVINIILEIKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PW64</accession>
    <name>A0A8H7PW64_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_009010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PW64"/>
    <dbReference type="OrthoDB" id="2140426at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2181427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="299" mass="33317" checksum="BBAA79C02AE3033A" modified="2022-01-19" version="1">MRAHGPPASLKSESTSYRPETSSSSSPSTPKYFYPTSPTSTLISSTANISRPRHTNTRYERHHSVSSNTSNSVITATTATSEPSAWQIQLTESILSRISTPSISTPSIERKSKTLGSSWERRYSDPLDKRYSTPLSMEPIPQLPPPAVARASISRARSTVPKVARAPAISISFDHLESERSFAKWLQKNNYSNLSRSIKYKPSNTSLSTAGHFDTYVDQHFSKISDSVKCIDKMRYSYQESVNQDSMCTVRFTIRYQNRHGEKMAKAKQINDLWVLAGCVNSHRYGGHRMAVRADGGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWK9</accession>
    <name>A0A8H7PWK9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CST complex subunit CTC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_006889</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWK9"/>
    <dbReference type="OrthoDB" id="2314520at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990879">
        <property type="term" value="C:CST complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045740">
        <property type="term" value="P:positive regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029156">
        <property type="entry name" value="CTC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042617">
        <property type="entry name" value="CTC1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14865">
        <property type="entry name" value="CST COMPLEX SUBUNIT CTC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14865:SF2">
        <property type="entry name" value="CST COMPLEX SUBUNIT CTC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15489">
        <property type="entry name" value="CTC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0779">Telomere</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2181964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1156" mass="130410" checksum="B78C30BDA2FF97EF" modified="2022-01-19" version="1">MNVVSIAELAASDIEENTNYATYGAYLTGEIEFIENSRDPTSDYECFMLLDPESFTGMKCRLTVFDRSILGKKIIAKTWHLRYLTEPLIDICMLETVTEAGSHPICTLLKQSRIARAQTMIEAELQFKALPFIDSVQDRFDIFSIIITKSPVFLDQNKKPYFILQIASDDMTAFVVFRGKNLRMHYQEIAVEMWYALTNLKMTTISDSDQHVFMFDGETSDFCQLIDEQVAYSYEKLAASITMPTRSEMPIDIVQPWERSKNESDHSIRCYGRITNVIDPILGFYIMDDILPICLAQSPTYFPLSAYWEGAVVNIQHAHIVTLHSNELGSALLDQYFHCASQSEVEQERSWRVIVCCIHTQITVEQLPDHNTTVPQPNPSMLKAFLSKNAFIEKYGFMTMVTWLEAFLSLKRKARDADTYVDSLVHQTDTLLQSIRVSSDQYSPRNLVEDFLSYHECTVFPQHTLSEEQSPFMNLPNYPTLSQLTNISNIPNLQQIPLSSSVNTDNPLANIPLQAWTYKLSDTKPDYCVLVGYISGGSDGRLYFADNTGRIPLIMIDEEQREFSHEVLYIFNNCTIVEEDLGYIDDSGNRVDSQCRYLVVKSSSVVSLQPIKSQITFCTSIPSTLEQDRIFAYEQDPNLPFKAEDHLNVMYVQHIPASNLQNNEHGKQYLSCTTEIVLFDLVNSDRITTSSLGPKAQKCTLVFTSDLQSLALLPQIKPKRWYVLVNISGGEPSSPSTLRLNEKSGIYPIISNGGHFKLRQFTHMYQSAVKPASSVASKDLDVKDLISITLVNSDLDEPSILSNSFHRHLVSFEAYVITKNFTESAQAGGEPDKYAQILYDNLTIGTGKPNRWLFLKLRSINSQNTIDVYFNVGRKPYPIGLVSGCKIKIHKAALKVSERTKLVYVVMLPSSGIEIINIPTDHKIRDDIEEVNDVEKRILADYLRDPSNRVYETVCYVKSVQQVSLSWVCLECGQVVINDNCYGMCAKGRRLFVAQAVATVTDGTADITVSIEGEDMVITLLRLSNFGASKLKEATYMHGEMVYSNWFAKEEATIRDASGTSSGANLTSRGRTLHSICTNPDIFSCVSLQAKRVVRRGDYDKNFANGHLFGTLQVLPVKLVSNDPEAALQSLVYARVRLHVLRINPIDVIEQANALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWZ8</accession>
    <name>A0A8H7PWZ8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_006842</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWZ8"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF92">
        <property type="entry name" value="AGL026WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="40"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2181917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="487" mass="54415" checksum="2A6E4130FE159C5D" modified="2022-01-19" version="1">MSSINKDIDISTIENTHVVPNDPELEAREKALVRKLDMRLVPMLTFLYICQRLDNSNIGNAKVAGLQTDLGLSNFQYSWAISIYTLGVMAMQIPSNMILERSRPSIYLPTLIAAWSVVSAMTALVHDYKSLLLVRFFLGITESGYWCGAVFVLSTFYKPREIAMRNSIFYCGNWLSGALGGAFAGAIIDGMEGKAGLPGWRWLFIIEGCITFVVAFFAIWALPDYPATTSWLTDDEKDLAVRRLGQGKPKEKFSFTGLKSALIDYKIWVFIIIFMAIQTGGQLNYFMPQIIQDIGYTGSMTQYMTIPVYVFAAILSLIVALLSDRQQVRSYYIAFCMSLAVIGYIFQIATTNKALLFFSLFLCGGGVWASLGVSLAWLGDCVPGPRDKKAIGFALLNMISQLSNFYGPQLYTNPPRYLVANIVILVYMSIGVVLCFGLRFLLVRANRRLDDKYGVPVVEKKQVIPDDRDEGDVAPETGVNKNFRYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PY10</accession>
    <name>A0A8H7PY10_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PY10"/>
    <dbReference type="OrthoDB" id="2376782at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2182357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="328" mass="36429" checksum="AD365D77259CE9A9" modified="2022-01-19" version="1">MSYTQPQDSNHHDAYAGQYPTPPQQYPPVSHTPESSAQYYPMYPSERSQQNMAQPYPQYQDAQNHYTAPSYPTYQDQGHTQPYPSYANAAPAPPHSTTPSQPYSYHTMPGVPTPNYQSNDIPSSSYNDPHAVPLTDYWENDHDHYPGRQDVDTAALLSHKNGAQSGQRQQAPLAEEEEFEEVVDMSELQEPKHVVAPASYNRPDRDGFLPGERRRGAKPGQQGPMDPESYLPKPYKEPRMGCCRNMSCCSVFCLLISVAFVVAGAVLMIYAKVAKGNCDNAASGHSTVQSMCDTVLYDGLFYGGIVVMAISGLVTLWRLIMCMCGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYQ2</accession>
    <name>A0A8H7PYQ2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_007492</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYQ2"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="86"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2182561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="327" mass="37247" checksum="C24A262C60E5D857" modified="2022-01-19" version="1">MSLNLQSKRKLNDGNEIPVLGFGVYQSNPGDETEQAVLWALEFTMIRLATATLIRLHVSTQYAIVASSEHRGSWLNVWQSANSVGYYNEESVGSALKKWLASNAQIACFTTLVKTNSDTYYKKIWVTTKLWDTDHGFDKAKEACEESLRKLGLDYIDLYLIHSPIPGKKLRTESWKALEELKKEGKVRSIGVSNYGVHHMKELLEIATIKPTINQIEVTPYQVREELCKFCTDNDVVVEAFSPLTMGLKLKEPRLNKIAEKYGKQPAQILIRWSLQRGIVPLPKSVTKQRIIDNSNVFDFEISAEDMEALTKMDEYLVTEWDPTKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYR6</accession>
    <name>A0A8H7PYR6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_007295</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYR6"/>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF11">
        <property type="entry name" value="CERAMIDE SYNTHASE LAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="12">
        <location>
            <begin position="115"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="336"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2182365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="372" mass="43337" checksum="457E52C6421AFAF9" modified="2022-01-19" version="1">MVSRSSSRFNRKRSARRASDKPYTLKEFTDYLAAHQIDAPLKVIVAILIGYLIGVPYFDRFIFITYQNPQTGLYGKGVGDIFFLFFYINVFTMLRAASMEYVLTPIAVAHVKSKRKRTRFAEQMWTVIYYSATFCVGTYLAYHSPYWFNTAEFWKGYPHVELTKLFKYYYLVQFSYWLQQIFVLQIEAPRKDYRELVLHHINTLLLISLSYSFNYTRIGNAVFVCMDLPDVLLALAKSFNYLDFRFICDSTFVAMLISWCYTRVYLYGCIIWSTATEPDLYVNFKLDPRNGSWFPYFAKYIILALEIGLFFLILFWTVMMFKVLAKVLLGSAAADERSEDEAEDEGLESEQGVVGTTSAIAHNSNMTPTKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZL7</accession>
    <name>A0A8H7PZL7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphate-induced protein 1 conserved region-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_006967</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EXORDIUM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZL7"/>
    <dbReference type="OrthoDB" id="2016249at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006766">
        <property type="entry name" value="EXORDIUM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31279:SF58">
        <property type="entry name" value="PROTEIN EXORDIUM-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31279">
        <property type="entry name" value="PROTEIN EXORDIUM-LIKE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04674">
        <property type="entry name" value="Phi_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034152216" description="Phosphate-induced protein 1 conserved region-domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2182041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="31387" checksum="0B1FC4CE44603F47" modified="2022-01-19" version="1">MLFKTASALAALYLTNLISAAPAAVSSMSGIHGKKAVAGLRPSSNSTSKVHNYATVDITYQGGPIMTGAITVYPIYYGTWSATQKDIVSTFVDGISSTGWWNIEETYTNSAGAAVTGPVSVGKEYDDNYSLGKSLADNDIETIVSNAIANGLPTDTNGIYAVLTAGDVAETSGFCSQYCGWHTYATINGATLKYLFAGRADACLSSCVASTNSASSPNGDVPVDGMISVLAHEIVESGSDPELNAWYDSTGQENADKCAWTFGTTQAATNGGQYNVVSGGKQYLIQQNWSAKDQKCEQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZM4</accession>
    <name>A0A8H7PZM4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cytochrome-b5 reductase</fullName>
            <ecNumber evidence="4">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_006216</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZM4"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF171">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0274">FAD</keyword>
    <keyword evidence="5 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="13">
        <location>
            <begin position="87"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2183212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="342" mass="37320" checksum="8AA835980D55441C" modified="2022-01-19" version="1" fragment="single">TAVSSAIRAAAAPSRFTAQRHTALGARAYSTEKPKSGGNGLLFAALAGVGIAGGVYYNSSSQSAVKQAAAAAPAVVAEQPKHAFDPKEFKAFKLKEVQPINHNTSVFRFELPEDSVSGLHVASCVITRYPITKKDGSPGYIIRPYTPTSDERAKGYVDFVIKNYPGGKMSKHIHDLKVGDELEIKGPIPKLNWEENKYNHVGLIAGGTGITPMLQIIRRVFQQSEGRDKTKITLVFANQTEEDILLRDELDSYAKKHPDQIKIVYLLDRPPQKWDGGQGFVTDKIVKDHMPSPNEPKTLVGVCGPDKMLELIAGAKNKDKSQGEVGGILKELGYTSENVYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZQ1</accession>
    <name>A0A8H7PZQ1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Squalene cyclase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZQ1"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000250">
        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF20">
        <property type="entry name" value="LANOSTEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="2">
        <location>
            <begin position="52"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2183417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="118" mass="13383" checksum="6372B26D5B43D00D" modified="2022-01-19" version="1">MIQFEKYPSAVIDSVEPPAFSDLVRWRLKVKHGAQTWHYLQSEEELRQWPPTRWEKYFLDLPFNDGGWGIHTQGISTVFGTALNYVVLRTLGLSADHRALIKARAKLHQLGGAAAIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0A2</accession>
    <name>A0A8H7Q0A2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Transketolase</fullName>
            <ecNumber evidence="4 15">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">INT43_006593</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4 15"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0A2"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF2">
        <property type="entry name" value="TRANSKETOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 15" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="16">
        <location>
            <begin position="355"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="116"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="526"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2183587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="679" mass="73775" checksum="9C6BD70C201525F2" modified="2022-01-19" version="1">MVNTIDTSAINTIRTLAADVVRGANSGHPGAPMGCAPMAHTLFAKYIKVNPKNPHWANRDRFVLSNGHACALQYIMLHLMGFNVSMDDLKHFRAIDSKTPGHPERGHTEGIEVTTGPLGQGISNAVGLALAQAQLAATFNKPGFEIFNNDTYVILGDGCLQEGVAAEAASLAGHWKLGKLIALYDDNKITIDGDTAVSFTEDVIQRFESYGWHTLIVADGDNDTDAIAKAIADAKAVTDKPTLIKIRTTIGYGSQNEGEEKVHGAPLAADDIKNIKSKFGFNPEEQYAVPKDVYNFWNTRAEENAKVEAEWNDLFAKYEKEFPTEAAELKRRLAGKLPSGWEKALPRYTPADAAVATRKLSETVLTALSDVVPELIGGSADLTGSNLTRWKKAVDFQHPSTGLGSYDGRYVRYGVREHAMFAIMNGIAAYQGLIPFGGTFLNFLTYGWGATRLSAVSNLRVIYVMTHDSIGLGEDGPTHQPVETLALVRATPNIYTMRPADGNETSGCYLVALENDHRPAVIALSRQNLPQLEGSSVEIVRKGAYVLQAQEKPDVVLAATGSEVAIAVEAAKALTQDGLKVQVVSMPITDLFDEQPLDYKLSVFPKNVPVISVEALTIFGWQQYSHTQVGMTTFGASGPIKDVYAKFKITAENTANVAKDTIKHFKEIGHVPELLCQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0L7</accession>
    <name>A0A8H7Q0L7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-type serine protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_006130</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0L7"/>
    <dbReference type="OrthoDB" id="2146116at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="12">
        <location>
            <begin position="284"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2183135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="489" mass="54028" checksum="0F8EBEF54E245ED5" modified="2022-01-19" version="1">MSQPYGNYEYNYPPPIATHSQNTPYRDSFETEIPLGTPVHNQATQDFSIPLSANSPHAHFAERSPSIIPAQAQTDPSVISSRSPPPVPYHSGAGFYSPPPKNGDINPYNNMPYSHQYEDYGSKIGEDDDRRMDSMNAVGTTGLLKPLDRGPPQQGFMRLESSDPQYIQPRTGPLAWILGPTRIPFFSYSTALVMVAVLVYELVKNNQLTGSIIQTATATEPFNPMIGPSSTVLITLGARFVACIRNMPEFPPTEQIGPCYTGSAQCSLEEICGFGGFKDPSVPDQSFRFFTPIFIHAGIIHLLMNMLTQLRLGAQLEKELGPLRFAILYFAAGVWGFVFGALFGSPSRPSMGCSGALFGLIGYMFVDILLNWRDTVQPWRELTKLAVTTIISLVLGLLPGLDNFAHLGGFIIGIVAGVMLIPTRRRATRQFKIFTWIARFCALVLLIVIFVVTVKEFYEVPDPSKYLLSSQICPNCKYLSCLPVSNWCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q176</accession>
    <name>A0A8H7Q176_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_006499</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q176"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000039">
        <property type="entry name" value="Esterase ybfF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="49"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2183493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="305" mass="33829" checksum="835991D4AADFC496" modified="2022-01-19" version="1">MLRNAGKVVATKAGPWLTLSQRTFATQHHEVVDLDYTKFSPDNAKSSKPPLVICHGLFGSKQNWKSLARAFTKRLNTDVYTLDMRNHGDSPHNKVHTYNAMGDDLAAFLKKQGIDDSILMGHSMGGKAVMNMCLRDLNPVSKLIVVDMAPAVLPLSSDFGSYVKAMDEIQKANLTKRSDADKILAQTEPDIGIRQFLLTNLKKDEQTGLYKFRVPYDILGKSLGKMSDFMEEETQPFEKPTLFIAGGNSGYIKPEKNGPAIKRQFPHSSIKVIKGAGHWVPTPTPVHAEKPEEFVNVVTEFVGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1K5</accession>
    <name>A0A8H7Q1K5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_006681</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1K5"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2183673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="183" mass="20620" checksum="ABC9D0F726AE8218" modified="2022-01-19" version="1">MNQYVNKKFSGQYKATIGADFLTKEVMVGDKLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVYDVNNTKSFESLSNWHDEFLVQASPRDPDNFPFVVLGNKIDLEENKRTISQKRAMQFCQSKGNCPYFETSAKEAINVEQAFQTIAENALAQETDVELYSDLNDPIRIDSDSSKEFGGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1V5</accession>
    <name>A0A8H7Q1V5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_000292</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1V5"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032787">
        <property type="term" value="P:monocarboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="6">
        <location>
            <begin position="27"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2184383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="317" mass="33211" checksum="09B839296369D10B" modified="2022-01-19" version="1">MSIATDRLNAIKGHLSGNHPKGLLAGEVAIITGSGQGIGKSCAELFAREGASVVVTDIDAGKYKLLFQQMVSENLVDRLLNSFITLGKSDQVAADINAAGGKAISIPGDVLNPDFPAALIQGTVKAFGKINHIINNAGFTYDGMLHKITDKQWDLMLAVHNTAPFRIVKAASEYLRKQDGENKCIINISSTSGLHGNVGQANYATAKAGTVGFTKTVAKEWGRFGVRCNTVAFGWVDTRLTRAKETGASIEVDGQKVALGIPQGAGNKKSTVNPFADIPLGRAGTTEDAAGGVLMLCTPFGAYITGHTLEITGGRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q201</accession>
    <name>A0A8H7Q201_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_006595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q201"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF22">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G11480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2183589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="115" mass="12671" checksum="7BB162638337602C" modified="2022-01-19" version="1" fragment="single">MSVLLCGNNAIDHPQKLLSPADHSLALTETVGNDLSRSALTVHTRTHTGERPHVCEHPDCNKSFSDSSSLARHRKNLITINLPEYYLTGAYIPENGRISANIKHVAKGLFDQLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q210</accession>
    <name>A0A8H7Q210_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_000270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q210"/>
    <dbReference type="OrthoDB" id="165382at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF82">
        <property type="entry name" value="NIPA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="534"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2184361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="568" mass="61994" checksum="033410343576ADD3" modified="2022-01-19" version="1">MAGSSPTDFVIGFLVSLGASTLNALGLNLLKLDHVRNSKKLETDQRHDCGRPMWHFGLYLYIASQLIGSTIALNFLKTQWVAPLGSAALIFNFIFAKMLVGTKIAKKDILGTCVVVASVIWIVVFGGMNNGEDPEENLSLDSLKALYLRPLFAIYFGGLNLITFTGLCFAIYASWASADEQRRSKVYVIKDLNLNTTKKTVAICMSVVGGLLASETLLLAKSGVKLFVISVSTGNNQFTDSISIFILIALLITAILQVYCLNTSLKLYSSVVVVPTFYGTYTAMGLINSIIYMDEIGTYPAWAIALVLVGIAVLIYGVMLLSGEKAEKPEEQPSTTSQIDPTVPSSTAPEELGDMRIMPLPSVPDIAKTYVPSDYARGKHTRMFSSDDHEFNCDLSGISLRDSGETVTGTLLRKDNNGRMIVDSTSTNLYGANGPTKLKGAKAVAFGFKSIMKSGRFRYFSSSNTNKDSSRSLTLPMENTVPDYNSLEAGDSSIDYHHLSSSSSKYVQDTEEYDAYLEAHDTALRRRAGPADALYSHSNNNRSSNDLHLDMLKSTSFARPNPDDDHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q287</accession>
    <name>A0A8H7Q287_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UV-stimulated scaffold protein A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q287"/>
    <dbReference type="OrthoDB" id="5594015at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018610">
        <property type="entry name" value="UVSSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049431">
        <property type="entry name" value="UVSSA_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28670">
        <property type="entry name" value="UV-STIMULATED SCAFFOLD PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28670:SF1">
        <property type="entry name" value="UV-STIMULATED SCAFFOLD PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09740">
        <property type="entry name" value="DUF2043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UV-stimulated scaffold protein A C-terminal" evidence="2">
        <location>
            <begin position="260"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2183361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="480" mass="54738" checksum="31B1AB79B75D3DEE" modified="2022-01-19" version="1" fragment="single">ESCFEILVPKLDDGLSLEEHDGDIQKNKSSKPGDTYKDNILSHGLGSSRYTIEIDLSERNMMDDVKESEENEIIFEKLRESYKIMQHKHLSKINGWLSNLVKIDADPGAKDDLLKRIINLKNDIKEAARKSNLLGIDLQVEQEAAKNDSDDDDDFGDADFEEVEVPDFEDVSHEAEASNARPFLEAKKLPPIQRVFPLAHEPQMSEDATYALPSQKRLELSSRQRESSPQAGKGKEKADVKRDELLKIAPVVESCFFGFQWGDDLYYWDKQDVQFNQSGLEYHHRFLGDGEGANTLSEETLNALKMRAVYYKPEWPKKLKACRAPLKNGSLCPRRDLVTCPFHGLIIPRDELGRPVDPKTKTPVVEGDTYENESVDEGKDEAVFSAVGASQPALWEELSNDVMMQQGIAPIESNKRGQKRKKKSTTPSALIDVRKKPETRMDRLQRRIEDPRMKKIVEESLDYDRDMKLRDKKANSWRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2Z7</accession>
    <name>A0A8H7Q2Z7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidoreductase AflY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2Z7"/>
    <dbReference type="OrthoDB" id="10004862at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="47907" checksum="6EB43F30B0E09D97" modified="2022-01-19" version="1">MTATTENLITTKNPNGFALPGITLESRQVLHELLVDNHEKHHIFFNEKQFHNHIPHQLMAAAALGSSPDTLRKIYKLHSAYQRPQMPVKYDINESNLADYVLKEDAYSSYLAFFDKQFKSMTVREIFDKYATIEPIYDGLFGGLYHPLIHFCYGVEFDNKLVMAEGLAMAAIQQQDPGFRVVEIFEMENLQLESKSIPEILDAIRNDQEIQRAVPYSEPMKFKTLGNNDTATKKLLKRTSHWHVAADAQDIDAKFKELFQTVVDLYAASQRHGKPYQLDFFLMHLLTSILFVYVLLPHLSLENQAKVVKVHFVKAAQWFVTRGSPKIDRSVVYAHKSTAPHTENPWFAVWNMSVENMDLHVVKVIRSLSKADELFAQDGDDYYVKAAQMTVETTIVDDPVKHDVWGRNPIGFDEAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q562</accession>
    <name>A0A8H7Q562_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q562"/>
    <dbReference type="OrthoDB" id="2247939at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2186312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="274" mass="31501" checksum="9C3DEA1A81A8DA82" modified="2022-01-19" version="1">MSSFTTMTVITQRWRPPRVLHDRHENLTVLFEFLPRETFDARIKELSQLIRKKYPSSYLDYYIFALAIIFVIASAAFSLVARAAGVSMWYPLILLLFPASLSLWTSRRRATMVNRTKEFEKTFRSYLGDLNKRDASQHQIKWSVRRASRHDRTAVGNACLVIELAQCDPESEVDALPLYQEVEGNENPQVMVQIDPPPAHEDADEPPNYTERDVVVLPMESMATDHELQPLSTSPSITFRQSIDQANAKEDDDDVPDDAVPTRRSLHQVMHRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6Q8</accession>
    <name>A0A8H7Q6Q8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6Q8"/>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="240"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="286"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2186124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="52991" checksum="0FD675114D450241" modified="2022-01-19" version="1">MSSEYESDQSNGSDMNTANQELATSVGVWNPEFFERWFGPPEGVYGQRNIFGYRENGRRREISSIVGGIRERELSSTYRSSHKQLGRHFVPKQHAKQMKQYEAEVYSGQYSEDGTLFYTCTKDFRVHIYDARDTEKLKKVKTIHALSGQWTLTDANLSRDNQWIAYSSLTPLVSLSSTDGYHDRNIALNFNESRLGISRIWSVRFSGSGNELVAGSSAQSEEDRSILLYDIERQKVIDSAGGHLDDVNAVCFADEGSNILISGSDDMSIRVWDRRTLHGEMATGVLVGHTEGVTYVSPKGDGRYLVSNGKDQCAKVWDIRTMVSPKVAEDTRLEPEYDYRNNFYPGVPRLHPKDCSVMTYRGHKVLRTLIRCHFSPPSSTNNRYVYTGSSDGRAHIYNLDGTVKQILDSNKIIGGNVHQQQRPLGWGFGYDRTPCTRDVSWHPYLPNIIASSWINDYGYLLKHDILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7Q2</accession>
    <name>A0A8H7U7Q2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_001411</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7Q2"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF33">
        <property type="entry name" value="ALPHA-GALACTOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034588487" description="alpha-galactosidase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="8">
        <location>
            <begin position="385"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2171935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="474" mass="51912" checksum="408D00A7F11677E8" modified="2022-01-19" version="1">MRFYYRNCLIANALALVVNASPVKRDNGLTVLKTTTTPDGFHSAATGWNSFGLQANNAVNPNWKYDQDHVIQQCDVLADTLHMDGGYCSLDSGWSTNNGDDYARLLYDTTIFDLPTLASHLHSKSLNLGVYVLPGAFCTDGNKTIYGTNIKLNSTFSGNNDGFLRCDFDFQKPGVQEWHNSVVNLFAQWGVDLIKLDFVTPGSPDNGGNLPANNSGSVIAYHNAIKQASRPMRLDISWKLERNNTFYDIWKANADTMRTDQDINNSGNTTFVAWEKVQRAIDNYRQYIVLQIPKNLPLSIYPDMDNMYVGNKQNLTGVTDAQRQTIATHWIGAAANRITGSDLTQLDSYGTELLTSPQALSAANFTAQYPMQPRNPGSGSTSAQQLQAWVAGPDSTGVALAVLANYGPDQGQGGFNTSLSGKQTVSISMQDLGLKVGTYQVQDIWQNISMGSKNSSLSTVLDEGESVFYRLSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U870</accession>
    <name>A0A8H7U870_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Splicing factor 3B subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_001108</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U870"/>
    <dbReference type="OrthoDB" id="10259687at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12334">
        <property type="entry name" value="RRM1_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12335">
        <property type="entry name" value="RRM2_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000059">
        <property type="entry name" value="splicing factor 3B subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000121">
        <property type="entry name" value="Splicing factor 3b subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000212">
        <property type="entry name" value="Stress response regulator/HFS transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034158">
        <property type="entry name" value="SF3B4_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034159">
        <property type="entry name" value="SF3B4_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="27"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="114"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="17">
        <location>
            <begin position="931"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="264"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="602"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="717"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="784"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="882"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1073"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1140"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="264"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="883"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="901"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1073"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1140"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1156"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1166"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="13">
        <location>
            <position position="980"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2175461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1180" mass="130171" checksum="B4A3E09869763BCA" modified="2022-01-19" version="1" fragment="single">DKKHPLAVSDLKEHIPMAQQIERNQDATIYVGNLDERCTETLVWELMLQAGPVVNVHLPKDRVTQSHQGYGFCEFMTEEDADYAIRIMNQIKLYGKPIRVNKATSDKKNLDVGATLFVGNLDPDVDEKMLYDVFSAFGVIVQTPKIARDTETGNFKGYGFVTYDNFDSSDAAIDAMNGQYLMNKEVNVSYAFKKDGKGERHGSQAERLLAAQAKKNAPMAVPGFGAPASNMGRPMPMAGVRPPMNGLPTAVPYNSVPTNAVGYRPPPPPPMGGPGPRPPYMGYGGPPPGPPGGYRPPPPQQYGGYRPPHAYRSGEMPLKSVEFCALVWIRKLATMENEHDQWLTGFLLVPEHVMLSGRDHSVPNAEELVDYRIKYQTLSRHTCQYKATNCRDETSEKSVDLPSRWMAGYISWNADMIREEARPKAVVRGVEAVNGKSQSAMHQPTKCTSHVTYDSAHQNWNNFSTPSQPIFDNNTSNTMDSIQQNAQPTSNGIPDFVKKLFRWVLQSICMNMLEDKSYNHIVSWGVNGETFVVKDPTEFSKVILPKHFKHSNFASFVRQLNKYDFHKLRNADDGKPYGDQAWEFVHPKFQSNKKELLEKIKRKTPNKGNRASGNAGQAGGSSGDNSANNSSGSQNNNGSFNNNQAAPAEFNALAANLHTQVSYLHKVHNDMAGHLQSLGNSYGVVLNEIMGYRTKMMAQDNLMQNLVQYLVQQEQDRQHERGQIEGRSSSFNHDTPFVPSSEAQKLIQSYSEVAKASVSQMNQISQKLQNLQQLTQVPWATNDRDQPEAILPPDSDPNDATTSTSMSHAVANTETFMKSTAATSSSLVANDLADLPSQFTANAANMNLTLPADKNFAGLNVLANSKNAEGLTVVTLGHLQPKHMSTSYTPSNEPAQSGQPSTATTASDTSSDNTMRVHRKTFIPGWSVPPRVLLVDDDSVCRNLSSKLLQVFGCTFDVATDGVEALKKLGLEKYDLVLMDVVMPNLDGVTATRNIRQYDTLTPIISMTSNTTDSDIMEYFGSGMNDVLPKPFSRNSLFRMLDKYCAHLKAIQRVQGVDAGIIHRGLATPNMLSSLQVGSNPQSDRGSQNSNGKRPLEVGSEPATTGGLVMESNSDISPAFLNLQDLPQFVSFMGLMQQAANGEESSSSHAGHWLQPDQQQNQNDHSYGREQKRAKLEVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U877</accession>
    <name>A0A8H7U877_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U877"/>
    <dbReference type="OrthoDB" id="9996464at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041646">
        <property type="entry name" value="VC0807_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="357" mass="40014" checksum="06F90FD8FD5E9359" modified="2022-01-19" version="1">MTGFESLFLGETDRLCMQYYTPAIESTLILQHSQSPYFLNMYLAYKAYKKHQQKKKEREASKANGTYEPRLSDTSKVTEVSMDFHPSTAGGAPPAFSWNETKPGSAKKQRLMLFGTLLVDVVLPIMLYEILKQHISQLVALLISSAPPCAMVIFRAIFHRRLDPLGSIIIISFAITAAVSVIDSNPRILLFKDSITTGSLGTIFLSSLIPIKIWRWQIKPMTYSIASQMLATQPNVQYLKNGEMIDQAFPEFIWENSPIFRKCQRILTAGWGVALLMELVAKLIMYFSTLTVDQIFIYGNVIAGVLLGSMGLVTTVFSHFIRKWTKQELDQVKERIETEAAMHATSSESCSNAGASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8L2</accession>
    <name>A0A8H7U8L2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cell division protein kinase 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_005354</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8L2"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07829">
        <property type="entry name" value="STKc_CDK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000144">
        <property type="entry name" value="Cyclin-dependent kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000184">
        <property type="entry name" value="cyclin-dependent kinase 5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2176121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="292" mass="33696" checksum="349AD6F80228DE79" modified="2022-01-19" version="1">MAPNLHLLGTYGIVYKAQNRDTNEVVALKRIRLDNEEEGVPCTAIREISLLKELKHPNILRLYDVLHTEKKLTLIFEYLDSDLKKFLDSYGGDIDILTIKQFMYQLLKGIAFCHEHRVLHRDLKPQNLLINKKGELKLGDFGLARAFGIPVRNYSHEVVTLWYRAPDVLMGSRQYSTSIDLWSAGCIFAEMSSGRPLFPGSSISDQLQRIFKVLGTPTEETWPGVSRLPEYKRDFEIFGRIPLESLLPKLDPLGIDLLKRLIEYVPEKRLSANEALRHPYFDDLRKREQSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9L0</accession>
    <name>A0A8H7U9L0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_005832</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9L0"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="64"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2174770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="259" mass="30245" checksum="7706F07F0BFD7376" modified="2022-01-19" version="1" fragment="single">AVGKTIAKSNQEQTQHETETQTVELESHETTLKRKRSSEKTAEELLKDEVTEIMDEFTTLGDYYKLVDKIGEGTFSSVYKAIDVRHDYYDNSSWDLSSICKDYERINLEESDSVITLENANENDQATNRKNYSDEPPTQFVALKRIYVTSSPQRITSEIEILHQLNGSECVVPLITAFRQMDQVMVVLPYFPHDDFRTFHRQMTMNDIRCYFRCLLTALKHVHQNRILHRDIKPGNFLYNYRHRTGMLVDFGLAQVCRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9P6</accession>
    <name>A0A8H7U9P6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_005937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9P6"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07197">
        <property type="entry name" value="nitrilase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF16">
        <property type="entry name" value="CARBON-NITROGEN FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2174875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="296" mass="33601" checksum="D03965FB7FB51257" modified="2022-01-19" version="1">MVKIAVVQFHVRQTINDEEADVDANIKKAEKYISEAKDNMVDIIIFPEYFLTGPLADKDHLVDWDHKYVQVFCELAKKYSMDIVPGTIVEGDKTEDAVINSAYYIDNSGKILMDYQKIHLWHPERKWLTRGSRGYQVVKNRFGITLGICVCWDIAFPEVFRELALTLGAQLIIAPTYWCYEDAGEVGLNHDGNSEVKLLNALCVSRAYENGICMVLCNAANDENSDHCPEQEIEHLVGRSKICVPFKGAVAECDHSREEMIMADVDILGITKDAESVYKIRKDWAEGNIHNGPQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAZ1</accession>
    <name>A0A8H7UAZ1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAZ1"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936:SF1">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN GUN1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936">
        <property type="entry name" value="PPR_LONG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2174892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="403" mass="45587" checksum="CAAED67737B13B1D" modified="2022-01-19" version="1">MSRSLIPRTACRSIQSINTIRMRNARFFSSSSRRLLPRFLTPKEEQELYQSITSSFRKQLATTSAKTQDFYSSIIEQSLFAVPKASPVSTSKLQDICGRIDAAVSSNRLVDLKKAQNELDISNAPIKYYNYLIRAFLRLKDINGAEMVLQNLPLGVLPSARTFTLLIQEYLSTDLDRAYEYMTQMQDMSCKLHRSFDYIVILRLHIKRDDPLAADFAWKDMIQHKDTVKPTMQLYTTYLGYLASKKNFEKASQVVQSLISSRRTNDSAQKTLTVVQYKTLLSLTNQLALNEHPQTARKLAELLLSSTLASAPSTAGGLPEGLLPTIVSTVLPSNMYSNIVTGYMDVGKYAQAIEFYKELKARSDVQLEPQLDEIIERARQSLQKASKKQSYHARIDLVNLAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBK3</accession>
    <name>A0A8H7UBK3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBK3"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="127" mass="13813" checksum="398652EF4B078DF9" modified="2022-01-19" version="1" fragment="single">DHPLWTETSKAPSAIGPYSQAIKVNNLVYTSGQIPVIPETGEIVEGGVKEQTHQCMTNLGEVLKASGSSLDRVVKTTVFLKNMNDFATMNEVYGTYFPNTKPARSAVEVARLPKDVQVEVECVALTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBR4</accession>
    <name>A0A8H7UBR4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBR4"/>
    <dbReference type="OrthoDB" id="5554402at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019419">
        <property type="entry name" value="AIM19"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10315">
        <property type="entry name" value="Aim19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="80" mass="8095" checksum="10AE6A4832A57BDD" modified="2022-01-19" version="1">MSTNSTLDNAAESPYPAWAISALSLAAIPAALAKKPGVPSFFQCAAFSAIFGGAGYVTNTGDAENGAGIATGMTMEHEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UC78</accession>
    <name>A0A8H7UC78_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar membrane-associated protein IML1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Vacuolar membrane-associated protein iml1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_005446</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IML1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04449">
        <property type="entry name" value="DEP_DEPDC5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045838">
        <property type="entry name" value="DEPDC5_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057068">
        <property type="entry name" value="IML1_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19418">
        <property type="entry name" value="DEPDC5_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24438">
        <property type="entry name" value="IML1_N_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="DEP" evidence="8">
        <location>
            <begin position="1318"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="441"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="557"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="671"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="808"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1722"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="557"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="574"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="812"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="853"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="873"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1732"/>
            <end position="1743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2176212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1758" mass="198319" checksum="35999B6C2B927D74" modified="2022-01-19" version="1">MAPVRAALPEDGVLPVFKPPAIPEQGSKVLTLWVHESSSQLAQHECVVNPEFLPNVTLGQVLRVYSSKGSQQQQMSTGSPAQTQQNKQQQQTQTQSERQPSLTEPVIVKVAAVDRSTKQLQISLHKDLADKLIWRSRMEVVVEPINSSMVALDHIELAFNDQYIGRSDMWRLQQSLRGTCVYSEKKILYAGIIKATVKRLFSRDSLVTSGYVDSSTRAIFRSGSAKFFLFIQMSKEMWDFDEDGELHFEKVVNNFLPDLFNRWSDNATNHVVSIVLFSRVFYSSTDYMDNDPGVNVMEDGRIYKDFYKVVADWETTENWRSYIGPLKREQLAFQREILLRKIGDKTVVCGEVSLAYEGNVLEAINLALNPFDRHYIDRDLLRSGLSIIMITPGAGKFFTAKKLLRLTNERMTDNGIAMDLVCLSKMPLHVTPLFVYKSSPPAAQKPNDAGKDGSPQSVSKQSKVPIVSPGMNAAGSAPGAKQKLFDLRDPLYYEDVGEERQLQYAVPHWVDCSFFQHSTGKYVKVDKFRAQCKMHEIQMMGIMEHDMAHISIPLLSEEDENSQSETEDEVTFERYNSANDPISNLSSSLQRNMITTRPSDLTNRVVGPPKAQENYLSRSGPLTDQQSLVNLNENMITQAGNNSAESSKEVDYDEYDSYAFKRSQRPRFARQLTSGTNRSVGMNLSGTRSDSLAPQSSSYEMDTSTHQGDNRMTTIGAVTGREMARANTVGALLDDSNVEYNKTWNHADNRKLASILSTSHQGSNRISFENGVRKEEGIIRAMDMFRGSPKEDNLGRFGLPRSEFRRSAAALQMTTAGSSSFDKQPDEDEPFTTSSSTVEPLPIRSGLHATGRPSERRKSYTRDSGHSPRASGLSASLSSMNRHSGNSDLAKTNMINATTTSNNRPSPTRAWTNRKEHNKQSIAVNPCNPHGMGTIFTSHLRRWQHAVPKFDVSAGSAVHWRSLVTPACLPLTTDYFPPAEELENMYDHYMYTVSASEDVNLYQAGDRSMPEYKKTENLLNEMISQRLAQGFQMIVEGAANMPVQKHMPIKGFIANPTDVPGGSGTMLGKDTKDQVNNNGSNATLNTIKSNTTGADDQIKNSVVKSNVSYLSMGHQVHKLTFDSSGQNVEVRRYVRTVQYDTKKTEYKCAVWPKHISFYRPKTVIFNYPNLMYAWNYLDHLVAGYQEELTDNLRFWRSRFIVIPMETLPANHNIIGGTNDVLDDEEKRLALFDTWWQSLRKAKSLTPAERDEMQKRAKKEIGHEFGLRLTTMDPSAYIMSEAEKALKLNDARGGMSPTTSPNLTKESKSKAIADAMRDPVYGLKIYDRRWHFTMFRNAFVGSEFVDWLITTFPDIDTREDAEKFGNSLMNRKPPLFVSSSNRHGFLDGHYFYRLQGEFALTQTKAWYSKSSPLKINNGSDIQDSSSAEFDINRSSKSKLTFDMSRFIIIDADPMQRTDRRETAILHYDTLHNPQNCYHFQLNWLGCTAQLIQDLLHSWSRQAERCGLKLVEGSVEQAFEDSENENPFQTPVPIRLAVQPPPIHLLQSQVEVPDQFFEIALVRHLGFVLDVEADSKFEQAQQGGVEVKYSYIKTPYPYDQYIHRSGVAFVQIRPQGEGFYWVNNRLFTNHTTTLLTRVKREREFSATTGHQWNNSSAAATPAMTHPDTLLRSFQEFCDDAQRLNEFWETTTRNLIVKNGLGWVYENAGEVDTIADGADIDAADSLNTPDVLGKTTTNDSTNSSSSYFLEVNGTNKAPDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UD83</accession>
    <name>A0A8H7UD83_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ESCRT-I complex subunit VPS28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_001290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the VPS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UD83"/>
    <dbReference type="OrthoDB" id="2671at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1130:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017535">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="7">
        <location>
            <begin position="92"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2175643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="198" mass="22033" checksum="F80B6F12E2150637" modified="2022-01-19" version="1">MADLFSIIVLMEHLEKAFIRDSITADEYTPQCSNLIAKYKTALNFLSDSVTDLESFMATYKLSCPAAVIRFKIGVPATYEHAIGDPSKDTGKSAKYVAEVVQHFITLMDTLKLNIYAADSLHPILADLIQSLNNVTTLPADFDGKAKVRNWLITLNGMKASDEITDEQARQMLFDMERAHTEFYRILSGESSPKESGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDV5</accession>
    <name>A0A8H7UDV5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Autophagy-related E2-like conjugation enzyme ATG3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_006972</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDV5"/>
    <dbReference type="OrthoDB" id="1584384at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.50:FF:000007">
        <property type="entry name" value="Autophagy-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="139"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2182046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="337" mass="38607" checksum="5FD2602AD418A70A" modified="2022-01-19" version="1" fragment="single">TMSAQDVYNNIYSRFSSVREYLAPVLKNSKFQETGCITPEEFVAAGDFLVYKCPTWSWEAGDESKRRDYLPNDKQFLITRNVPCLRRAKQMEYTEDDKETEVKGGGDGDNEDDEDGWMYTHSDRVYKTIDEIARDIVDSDDMPELPPLGALSIEDNRTATEKAEDADINPDDIPDIDDIPDMEDDIEEEEDPAAIATTNVTSQTGSSAHDSESKILQVRTYDVFITYDKYYQTPRLWLFGYDEQRRPLMSKEVFEDISTDYVKKTVTIEPHPHLSMSLASIHPCKHADVMKKVIERMSASSSKDLESNLRVDQYLIIFLKFMSSVMPTIDYDHTISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDZ4</accession>
    <name>A0A8H7UDZ4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pyroglutamyl-peptidase I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_005642</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDZ4"/>
    <dbReference type="OrthoDB" id="407146at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016920">
        <property type="term" value="F:pyroglutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000816">
        <property type="entry name" value="Peptidase_C15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402:SF1">
        <property type="entry name" value="PYROGLUTAMYL-PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00706">
        <property type="entry name" value="PYROGLUPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2176408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23545" checksum="1EDE0296EAB0BA18" modified="2022-01-19" version="1">MVVNITEDSVNVLVTGFEVCGKHAINPSWEVAKTFSGTTIKSGKKEVLLSSIRLPVEYQPIIDIVPPLHREPHNFNYVFHIGVGLNGPIRMETLARNGPYNKIDNRNETPVGEVIEGPPQLFTKVNVEHVIEWGKSKKGWKDNVRLSTDAGLYLCEWTLFTSLRESVKEDSSNATVLFIHVPQIGEGEGMMTLESMTQTVSEIIEGVIANSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEL5</accession>
    <name>A0A8H7UEL5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Plasma membrane proteolipid 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003913</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEL5"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF42">
        <property type="entry name" value="UPF0057 MEMBRANE PROTEIN ZK632.10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2180125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="7725" checksum="3A75885BB09BC560" modified="2022-01-19" version="1">MALACAVVIETLTAFLLPPVAVLLVRGCGCSLVINILLTLLGWIPGVSTILGCVIHALLVTCGPRPGSPRRARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEY0</accession>
    <name>A0A8H7UEY0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_006220</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEY0"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000160">
        <property type="entry name" value="Casein kinase I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2183216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="415" mass="47557" checksum="FD549A175D54A18A" modified="2022-01-19" version="1">MSHSHSSARSMTNSTNIVGVHYRVGKRIGEGSFGIIYEGTNLLNGQQVAVKFEPRKSDAPQLRDEYRTYKILHGQDGIPTAYYFGQEGLHNILVIDLLGPSLEDVFDLCERTFSVKTVALLAIEMVTRVQTIHDKNLIYRDIKPDNFLLGIPGTENANKVYMVDFGMAKQYRDPKSKQHIPYRERKSLSGTARYMSINTHLGREQSRRDDLEALCHVFMYFLRGQLPWQGLKAATNKQKYEKIGSKKQSTPIDELCKGYPEEFAIYLKYVRKLGFEETPDYDFLRELFAKVVRQNGDTEEKVYDWMLLNDGKGLEQRSGSRQQTRHKQLKDSTQIASNIRQAQGKRTAGDSPYKARDPPAIKANIRHGYLENSTEESHGFCRKICLQSEIKSFAVDLQDSDLILTMPTSQFFIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UF31</accession>
    <name>A0A8H7UF31_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Eukaryotic translation initiation factor 2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_006387</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UF31"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000599">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="9">
        <location>
            <begin position="218"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="419"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="517"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2183381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="585" mass="65275" checksum="EFF7D1F90EDAD0ED" modified="2022-01-19" version="1" fragment="single">SVYFGRYEHSLTFFFPDRSLKELAVWNGYPDYKPLDGFDKPSGSTRIFAYSKNGHVFAYATNESVKVFDAITNTHISEVVKANIVDVWFSPKGTYFVTWERPTKLEDGSGSNNLIIWESKTGTELASFSQKAYNNWNFQWTEDEQYCARMVTGELQFWESKNIGKAVWAKLKLEGIAQFSLSPGKSPAVAVFIPERKGAPAIVRMYGLPNFKSALSNKTFYKADKVQMYWNNLGTNLLVLTQTEVDKTGKSYYGETNLYYLAVAGNFDCRVVLDKEGPIHDVTWGPDSKEFVVVYGSMPSKATLFDHRANSVFDFGTNPRNFVKYNPQGRIICFGGFGNLNGTVDFWDRKTLKKICTFSAANSSYCDWSPDGRFLMTATLTPRLRVDNGFKMWHYTGTLIYSESIDELYQIDWRPAPATSYPMRALSPGPKPIKTDTNGTESKPAAQPLGAYRPPHLRGSATPPLSKGDSPRGSTPPQRSSVPGAPVGASPKIGAKSNNKKKKDTKKPEETNGTVHESSNAAAEQAANATGLSEKDKKVRNLEKKLRQIRELKERQLKGESLEPTQVAKIATEASLAYELAHLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFA3</accession>
    <name>A0A8H7UFA3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_007876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFA3"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2177219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="177" mass="21048" checksum="D41715DCE0E669B4" modified="2022-01-19" version="1">MEEFRHMMFFEHVRYIDDVSFKDAFIMSVVYSRDAVKIKQVRLHWMKNQIKRQKEDEMDDVLNAAFLYAQYKGNEEVVEVCSPYDNGDTSFTYVFQALLNFEEYAIFMELEHNLDTSIIVSNASKLTMQFMVDYFRVLVAESIKGLELLQDAVLIMLLYIKAISFKIRDCRLDEQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGB2</accession>
    <name>A0A8H7UGB2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGB2"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="13"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2178179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="349" mass="36784" checksum="866469AAB04250B0" modified="2022-01-19" version="1">MSPTNQAAWQIDKAVKPSQVKSAPYTSPQANEIVVKNYAVAINPVDVGIQELGNKIFPWLSYPTILGVDLAGEVVEVGSDASSRFKVGDRVIGAALGALPEINSPAQGAFQNYTVVIANVAAKIPSHLDYAQACVLPLAVATAASALFLKEYLGLQLPTFPAQQPTGKTVVIWGGSSSVGSNAIQLAVAAGYEVLTTASPKNYDYVKSLGASQAFDYKDEDVVQEIITALKDKQVAGAIAIGLGSLESCAHIVNKTNGSKFVADVMSPTLTKPLPEDLGVTSKFVMGSDLRKNEVGEAVYGDFLEKALEYGKYVAAPDPEIAGHGLEQIQYAHEAFKKGVSAKKIVVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGC6</accession>
    <name>A0A8H7UGC6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_001729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGC6"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2178883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="93" mass="10251" checksum="4372227A7E7F0B56" modified="2022-01-19" version="1">MAAQSGSTEHQSRVPDIEIGAFRALTKESSMSEIIDMVIHSRDDDAVKPNLAGLKGYLELDRDLKLLEAVIGSYGQTLPDDQAYSLFIHLMQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGZ8</accession>
    <name>A0A8H7UGZ8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_001700</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGZ8"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18044">
        <property type="entry name" value="DEXXQc_SMUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048761">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21138">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase SMUBP-2/HCS1 1B" evidence="14">
        <location>
            <begin position="7"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="12">
        <location>
            <begin position="189"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="13">
        <location>
            <begin position="433"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="615"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="616"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2178854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="664" mass="73814" checksum="DA1F4E68D9DCD76F" modified="2022-01-19" version="1">MESFIDSQIDLVAKERKLEVEDTARLLSACSPAQLQKRGVALVALRVASMRTGMGGKSLLELELAQPLTDPPRLPSHKIRTGDIVGLQEYKKDKPLSQTLLSGVVSKATDTSVTVALSQDRDNDEIPQELQDRCQIVKLANNVTYERMNYALNDLKKDAASSPLQQVLFGLQSPDIEQTEPVNFFDETLNHSQREAVQFALDSKHIALVHGPPVLTETITVIGTGKTYTLIEIIRQLTVVQEKRVLVCGPSNISVDNLVERLSRHKISIVRLGHPARILPSVVDHSLDIITRTCDSGQIVADIRREMDETLTAISKSKRYAERRGLYGQLKDLRKDYRVRERKVVGEIIQGSQVVLSTLNGCGARNMFNQEFDVVVIDEATQALEAECWIALRKGKKAILAGDHLQLPPTVKSQSGVSSTPKVPKQLTKATSLSVTLFDRLLAMHGTSIKKMLKVQYRMHQSIMQFPSYELYEGELIADPSVAERLLCDIESIDDTDDTGVPVVFIDTAGAGIIEAQDDEEEESKLNEGEVDKVVEHVDKLIAANVQQEDIGVITPYTAQVSRLNRAMKEKWPDIEIGTVDGFQGREKEAIIVSLVRSNDEHQVGFLAEKRRLNGDSETLSGTSTNPNGKQGKKNQPIVADGGFLQRWMTWLSEEADVRYCEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHT4</accession>
    <name>A0A8H7UHT4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHT4"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20208">
        <property type="entry name" value="Bbox1_DUF2009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.40">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein, ZZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038446">
        <property type="entry name" value="CEBP_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018553">
        <property type="entry name" value="E2_Ub-conjug_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057668">
        <property type="entry name" value="E2_Ub-conjug_enz_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31560">
        <property type="entry name" value="UPF0652 PROTEIN C16A11.03C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31560:SF0">
        <property type="entry name" value="UPF0652 PROTEIN C22H10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09418">
        <property type="entry name" value="DUF2009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="2">
        <location>
            <begin position="40"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2186381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="627" mass="70606" checksum="5A61AD094F887E16" modified="2022-01-19" version="1">MSNFLDHGEATLPIKESLSERVSLMETDEDLTASQELPTPKLDYCVECKDQEASIFCEQCDEEFCEVCHDMLHRTGNRRRHTTKNLKRVSTMSLDNAIGSGPIGEKLTADDQEKVSSVLINDKPGFRLIEVCFLLPKAISALSESVSDSSQLDGTVISSSGATFGEWMIKRSKYVPLRLNSEERIKLRLLEAALNVSEYTDKVDIISYTSKTKRIVAQIKDFCAILSGLVVSGDYKLGQELFANRGFSENEEFFQSVFEVGRRHKIQNPEKMRSSYGKLMYLLMDSVTPEVEDLLGFSCVIPIKTVYNFLKETECIELLHDDSISLATREISPDGKSRSQIDAEVKRKENAIEHLCQTYQNEMISPEGIKRCLSSLSDNHAFLRANRDPCEKMLKYLAKYFSPAKAEPGYSLAISAGRGGHRLTHNHATQFAYVHQTLNLWREILHEMFMLWSLSDEDLLSANPYRLTNTGQGLHRIQACPSVGREMHRTLHRAQKKSGSWIGSSVIHLGDRNVANAFMFIDKAMSRILNPIVLTLEKLDDLQENAGLRDYVNGTFGGIEHCRKDILLDFFRSAFDGSGADNFFDAGSCIDGRLTSAWNWCSQIEKKSYFPVFLLTGFVGFDGGGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UI75</accession>
    <name>A0A8H7UI75_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_003796</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UI75"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="45"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2180009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="451" mass="49890" checksum="9698E0C07A5BA4BA" modified="2022-01-19" version="1">MNSSESPDKLYINELSEVGSQESQTARENDRIVERRLLWKIDLRILPILTLLYVFSAMDRSDIGNAQVAGMQKDIGASSQQWTLVAALFYIGYIVSQPVATLFMRRLNPPNLFAFACCLWGTLTILMLTSKNYQQATALRVLIGLAEGLLQAAPFYLSLWYKITELGTRGAIFFSVASLAGACNGLIAYGLETNFSNAPPFKPWQWLFLIEGIMSVGFSLIVWLLLPPVPENVYFGFTADEKRIAIARSVQAFNTIDAKVNKAHIKDIFKQPFIYFMVIAYSGTIVALSSLTNFLPSIIQGMGYSSVDAQLMTGYILLLAVRASVVGRYVALCIIAAGMYPSVPIVLTWTNVNIIGYTRRATAAAAVNMIAQVFGVVANLLFTKPPYYTSGIAFVVAAMGVAVITELIAIFWLRAQNKKKRVAHATPEAEQQREKSYEDLGNAHPDFFFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UII4</accession>
    <name>A0A8H7UII4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_008655</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UII4"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="68"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2181073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="560" mass="61526" checksum="1CE42491C2FD42B8" modified="2022-01-19" version="1">MEKTEIESYGHEDPNSYRGETPGSHYPPYAKYGSEYDDEAKQEVVDQTSDIGQVEEQAGTKRGLSARHIQMISLGGAIGTGLFLNSGGNIASAGPAGALIAYIVIGFMVFCIMTCLGEMATYMPISGSFNLYAAKFVDPALGFALGWNYWFSWAVTIATELAAAATIIDYWFQDYQPVPNAAWSAIFLVLIFGVNTFGVRVYGELEYWFAMIKIILVIVFLIVALLVTTGAVGGHTIGFSYWKDPGAFNNGVLGTVGVLLSAGFSFQGTEIVGVTAGEAKNPHKSVPRAIRNVFWRIVIFFVLTMLFIGMCVPYTLPDLSTSSDSTTASFTIIFNLAGIGVGAHIVNAVILSSVLSAANSSLYTCSRTLMALARDGKAPSIFARVTRFGSPLWATLGSSIIGFACVFVDLYRPEDAFVWFLSITAVTGFISWTGIAAAHLRFRKAYVAQGRDVNELPYRALWYPFSPIFAIVLTVLIVLAQGYGAFYPQWDVLTFFIDYIGIAPFILTYGGYKIFKRSKVIPLLEVDLDTSRYIPTYEDEIENQEYEHRPWYKRVFGAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIQ0</accession>
    <name>A0A8H7UIQ0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Neurochondrin-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_000489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIQ0"/>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008709">
        <property type="entry name" value="Neurochondrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109:SF7">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05536">
        <property type="entry name" value="Neurochondrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2184580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="56562" checksum="4B07CAB04C042F70" modified="2022-01-19" version="1">MSVPVSKENRAAEIDQCLKLLSASASDESKFTALLILPRLLDANDENTIQHVFGRMNFKFLERLMKSSKCINSSVTLVFRLSYKLQWMFVSLTSKIEPTAEVPETVMQEIAVNILSFFSNVDSLKSSEDLIARIPTLSTLIKPSDSNDITKEVLMMVMRLQDSELAISATLSSTVLSRILSLLGINATSEEQELAKHLCVLTYGNAFTKIEQQNSQILRTAVLESLKFTLLPTLSSTIRVKQDVSKFIAVDLLHRVLNECPTDITKELYSTEQQRVNIWCENIRSGLRQILTSKTVSDRRDQAFSLIATLLRHIGPNWLFCTLGKTAAVAHEAPQQLEKQPAGGAKGKPVVTEESEIDARFPALLIQLASLEARLILDELGGDPDAGGRKTLQEAPSSDRSIAMLPMFYQIIESGIQYLTSEDLDLQGTDIDLIFKIRNILRELFKAIIDFLNDIQSKHAEQDVFENIVALASVRLLAIWTEEDDSLNEEMSSATLTMVETFRDTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJT7</accession>
    <name>A0A8H7UJT7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJT7"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2185780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="37901" checksum="6270C49B523671AE" modified="2022-01-19" version="1">MDGGREWADNREWIKEVQRFKKVFSQRSSNTKHYYMAGNHDLGFGDGIKPSVVERFENEFGETSYELSLDSHSIVVVDSVSMSSTSAQINHKSRDFVRQLRPSDKPRILFSHVPLYRQPSPISGTLTAPAAEDMCGPLRQKSKQIRQGVGYQYQNLMTKELTDIILTHAQPDMIFSGDDHDYCEVFHAFEARKIPEISVNTFSMAQGVKYPGVVLLNLYAGDVPKSESYTTKLCLLPDQISIFIRYAILLGITLAGLLANNILDLFGYSLLSTSSPIMPSTRQEADKADAREHRYLSQRRILISRSLEAIKRTAKDIRQIALPSLLFYLICVLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UK21</accession>
    <name>A0A8H7UK21_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_002473</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UK21"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF20">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="18"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2186035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="263" mass="29709" checksum="72738EC8DCEA13F6" modified="2022-01-19" version="1">MDMAQSRQRDAWIMQKSYSRTLDHMSSRQDIGSPPYSRGTSSSGSSIDESLPSPVLEELEMPPHPASSQYAFMNKHQPPFFEVPMSAEAPAWRPASYAPADLAYDMYTMPSDYTAPHYPATPQHHTNHFRQWTDYTGRYPRYQPYCSPTLYHHHPMQLPMPSPTQSITSSSSCSSDTYKKPSKSSMPGADFMTSFSAKIEKPATGTPKRYKCELCSKRFTRPSSLATHKRSHTGEKPFTCAFKGCGRSFSVVSNLKRHSKTHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKJ6</accession>
    <name>A0A8H7UKJ6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_007201</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKJ6"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="26"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="383"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="487"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="545"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="569"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2182274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="599" mass="67042" checksum="FA5CF8A01AC12174" modified="2022-01-19" version="1">MTQESKKRVCYFYDANVGNYHYGPGHPMKPHRIRMCHGLVMNYGLYKKMEIYASICLTSRAKPANKWEMTQFHTDEYIDFLSRVTPDNMEALNKEQAKFNVGDDCPVFEGLFEYCGLSAGGSMEGAARLNRGLCDIAINWAGGLHHAKKSEASGFCYVNDIVLGILELLRYYPRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKYGEFFPGTGELKDVGVGKGKYYSVNFPLRDGIDDESYKSVFEPVIEKVMEWYRPSAVVLQCGGDSLSGDKLGCFNLSMKGHANCVQFVKKFNLPTLVLGGGGYTMRNVARAWAYETGVVVGQELTPAMPYNDYYEYFGPDYRLDVKASNMENMNTPEYLEKIKLQVFENLSRTAFAPSVQIQEVPADHDMSDDEDEDNPEERNPERLWDRRIVPDNEFYDSDDGEMDNQPDGKQSMHQQSYANEATGENMNGSASHNTKQSPPRVTITEDEEMELAATLAEGEDEITSRAEHSKDDATPIPSQSFADKSVDETAEAIEPQGLYSQHLRCFEPTIPNIMNTVANSDNHDPTEKETSQSIPVAVSANPSTGIASEQEESQSTAANQDSGSDPMDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7ULK2</accession>
    <name>A0A8H7ULK2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_002685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7ULK2"/>
    <dbReference type="OrthoDB" id="27823at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032185">
        <property type="term" value="P:septin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018808">
        <property type="entry name" value="Muniscin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF54">
        <property type="entry name" value="SUPPRESSOR OF YEAST PROFILIN DELETION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10291">
        <property type="entry name" value="muHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD" evidence="3">
        <location>
            <begin position="527"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2186247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="774" mass="85494" checksum="FE1808039EF36375" modified="2022-01-19" version="1">MQSVNDNGSIKNQTYVRAFLTETPEVGLDILQSRFSNAQKLDTELAEYFKERAQIEDQYAKSLVKATKKLFMSDPTILGHLAPVWTKLQGELTEVSNIHGAMSHSILNEIEAELRTAPQRYQKSNQGKKAIDRGGSILFKRGASSKSLNQDVDPSWFMKGPDILAEVETDDRQRLQRLSNLIQKFEEIQAEHLRQRISMADTTLSTCLSYVPDDEIKDFARTHSKNLKVGQPAAPSPAGENAPSSSPRQGSQVFDDVTPTSSTPVAPRPVSTLSSSRRASSRDSKLFSAFSIRRKPKGERLDDNPNFYPQMEYASADAQAYSQPSRQYDSGLKNTQGITKSERSTEIGNNTVPKVDEQGYSIPPANRSLIPGSIGEEVANDGFFDDENQRITNHKYHVDIKQNAVQEEKEEDKVTMQRMASILKEKNSPSPRRPRGRRDPARNSTLNERLPTDSSLNVNPSHGLTRDASVSTLDSNSYNPFTSSANEAHHTPRTLTPSSSVSVSPTMGSMELPSIATPLPTVEESSTPSLSAYIIETVNARLKGGEADQKHISGEIALQYSGPVSSADMLVFKLDKNDRIESLYPNNHLLQAISEEDGTFGIGKDELARLKGRSVVCFKYKLKGQDITNREILPLSVIPAWRVEETCTKLIVKYKANAAMTTKNMAIWVRPTSKGVTSVQSTPQGAWNPERHVLSWDSETLKMDGSLGQLLAMFNTSVGSAPQPMVALTFNAEGATASNISFDTSQRMLNSNQQYIQIQVIHKTLRSGRVIAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UMR2</accession>
    <name>A0A8H7UMR2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_000418</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UMR2"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000916">
        <property type="entry name" value="ABC transporter B family member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF641">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER MDR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="297"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2184509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="542" mass="59423" checksum="9336C2278D2657C6" modified="2022-01-19" version="1">MTDTPDAMRSQVAYFSMWFFIVAIVLFFAYCINGTAFGYVSEHLQKRVRNLAFVSVLRQDIAWHDEEEHSPSALIASLNTDAALLGGLSSTVIGTIFSVLINMSAGIILAHIVAWKIAVVILAAVPVMIVAGWLRIKVVADLHARHATAYVRSASLASEAVSSIQTVASLGREKDVCRLYEEAIQAPYEDSIKSLLKGNAWLSLGYSITYLLYALAYWWGSQLLSNGEYTSTQFFIVLPALLFSAQASGQMFSLAPDLTKAKMAAGRIFDLIELQPTIDIASERNAIPKSTNTVGQVTFENVHFRYESRREAPVLQGLNLQINAGQFVALVGESGCGKTTALSLLERFYDVNQGSLLVDGQDVRSYEVNHLRSQIALVSQEPILYSGSVSFNVLLGSEGIQSIDDVHKVCKLANIHEEILSMPQGYDTAVGFRGSKLSGGQRQRVAIARALIRNPKILLLDEATSALDSQNERLVQDALNKAAEGRTTIAIAHRLSTIRRADCIFVIDGGRVVEQGTHDQLLAKRSKYYTLFQHQTLSSGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UN30</accession>
    <name>A0A8H7UN30_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_002250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UN30"/>
    <dbReference type="OrthoDB" id="2240906at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2185813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="94" mass="10466" checksum="E05661D709C24086" modified="2022-01-19" version="1">MQPLVLDHVAFGEALSLHINFHTRSGNVKQQKVATISENCPVTAKESKYVTYTRRWKIPASAKPGSYAVDFSEKFRTRGGTFTAAETVKVHVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UN69</accession>
    <name>A0A8H7UN69_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UN69"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="2">
        <location>
            <begin position="57"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2185933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="344" mass="39447" checksum="E745679B6BEB0AC8" modified="2022-01-19" version="1">MNASSKSSRQSSPATTALSLHRRSPAYFSKRHQSLLSNLKKGNVPGKEHSVRHGSCTFIQTVGKKLGFPQTTISTAQALYHRFYLFYSIRTYSPNDISITAIYVASKIEETIKKLRDIFVVIHSVKHPESKELDPEQVSEERRRRIIGYEKLMLETLCFDFQIRHPYEVMVKFVKYINVHQDIDGREVARKAYMLLVDSYKTPLCLEYPAHSIAAGAIWLADLLLKDEAANFQGLDKTKPWDLVFRTRLDDMEDVCHQILDLYIQTSSDQDMQRYTRIKIQLNQEGQRRGPDVYLQAISDPEGLGSSVTADKQVVYSNSTLDMANTNQHTVCYQFVSMSPHDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UP84</accession>
    <name>A0A8H7UP84_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="14">ETF-QO</shortName>
            <ecNumber evidence="14">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_002462</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 14">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="14"/>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UP84"/>
    <dbReference type="OrthoDB" id="437331at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000012">
        <property type="entry name" value="Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049398">
        <property type="entry name" value="ETF-QO/FixC_UQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21162">
        <property type="entry name" value="ETFQO_UQ-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 14" id="KW-0274">FAD</keyword>
    <keyword evidence="5 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <keyword evidence="12 14" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="15">
        <location>
            <begin position="584"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2186024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="624" mass="68965" checksum="5D0D07CF5F601666" modified="2022-01-19" version="1">MPSSILLLRQASRRLATAVRPVLASRVVPRIALRPTTAIALTSRALSTSASRAIWSPVDPKTLPEDDPRRAERFIDETDVVIIGGGPSGLSAAIRLKQIANEKGEECRVMVIEKAGEIGAHILSGAVIEPRALDELIPDWKEKGAPLDQPAVSDHMRFLTPTGSIPLPHPPQMNNKGNYIVSLNNFTKWLGEQADELGVEIYPGFAASEIMYGEDGSVEGVYLNDVGLDKNFEPKDSYERGMGVKAKMTLFGEGCHGSLSKTLFKKFDLRKDSQPQKYGIGIKEVWEVAPEKHEPGKIVHTIGYPMDIHSYGGSFMYHFEPERRLVAVGFVVGLDYENPYMNPYKEFQRYKQHPFVRDVLEGGKCISYGARALNEGGFQSIPKLTFPGGALIGCTAGFLNLPKIKGTHTAMKSGMLAAESCYDAIFGANAQESGPIVLDSYEENLKNSWVWKELWAVRNVKPSFHGPLGLFGGVMWTGLDTMILKGKAPWTWKHKKADWESLKPAKECKPIEYPKADGVVSFDLLESVSRSGTNHAENQPVHLRLRNKDIPVERNLKVFDGPEGRFCPAGVYEFVDDDANPGQKRLQINSQNCVHCKTCDIKDPSQNIDWTVPEGGGGPQYAWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UPM7</accession>
    <name>A0A8H7UPM7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cation-transporting P-type ATPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_002837</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UPM7"/>
    <dbReference type="OrthoDB" id="158672at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000083">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="877"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="907"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="948"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1016"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1054"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1087"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="11">
        <location>
            <begin position="124"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2186399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1123" mass="123266" checksum="225217FEFFBE009D" modified="2022-01-19" version="1" fragment="single">MADNGDLEKVSTQPMPRSQTITFAGPNNIPTNNGGSKITSAKRGSMATDRISFTSRRASLAVSTAGDPQSIVMYRTLSIKIEETQRSGFTKKYAPSINKSFWKFFSREKKQAGPTADEELATLDFHKVESNELFQRFNTSEKLGLESISAKSRLERNGKNVMSRPPSNLPKKLFNYMFGGFSGILWIAGILACLSWKPIGEPDPQAINLYIGCVIFIVILINIAFTVWQDYTTSQVMKSIHSMLPATCVVLRDGEKKQIPASDLVIGDLVVLSLGIKVPADLRLVQVSSDLRFDRSILTGESEAIPGTIAMTDNNYLETKNIAFMSTHCTQGSGLGIVVATGDKTVLGKISKLTSSKSEETTLLQQEINSFIIKVAFFSITLGIILIAVWAAWLQKYHVGFMNASGIIIVVLALIVAFVPEGLPVAVAITLNIIARRMQNSNVLCKVLTTVETLGSVSVICSDKTGTLTENRMTVRNVAFGEHQMQIGDYTEIKALAAKGPESAMRKLQLAAALNCAAGFAAGQEQKDVNERETVGDATDSAILKFAESIGSVKVEQESFEEVFKIPFNSKNKWMLTLRKPVSEAAIKEVGKETALLYVKGAPDVLLPRCSYYMTKDGQEKSLTEEAKIAINKSQEQLSSQGQRVLALCSRTFSLPSKSLTLEGEKIAESAEAANCDLTIVGLVGIVDPPRKEIPSVVATLRKAGCRVVMVTGDFSITAAAIAKQCGIITVGAVDNASVIRDSSKVPTRRDIEDEETSFENNITALVISGSDLLEGFSDHEWDIICSYSEIVFARTTPEQKLRIVNEMRARDAIVGVTGDGVNDAPALKAAHIGIAMGAGSDVAIAAADMVLLDNNFSSILVAMENGRLVFDNLRKVIIYLLPAGSWSELWPILWNIFLGIPAPLSSFLMIIICIFTDLAPSCLGMVFEGPESDLMLRPPRNPKKDKLVSWSLLGQAYLFMGMMEMICAHSMFFFYMYKYAGIPLHRLAYCYENWADGFMGYSIGELNNFVNVGQSIYFVTLVMLQLFGNLFASRTRRLSVLQKNPFWGPSRNLRIPIAMCISIAIVVIVLYVPFFNNVFQTARIPIEFWFIPIPLAIGMLVMDEIRKLICRTYPRSIIAKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCG7</accession>
    <name>A0A8H7PCG7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCG7"/>
    <dbReference type="OrthoDB" id="2349146at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="310" mass="34804" checksum="05F178E8A0387EF3" modified="2022-01-19" version="1">MSAANTTTTASSGIAIDSTSAESKAFFNTLSEVLDGISIAVGCIVIVAVILIRIYRPQLGQTITVRLSGWIALADILVCSIQNSQIGGFVKEPAWAAPYYMWGSQYVWQLLGEVYCAIVIVLVLVKLFRLRNYQKEQSSVRNQNQTDSADQHARSGRRITFVMLRIVWYPVIPIITQTWLIVMNSVPPPHNLPYININNSMYMKVVTDVRKCDKTNYANGASFSLVMSALQGILNGIVFCLNPATYALWQEWRNKQTEMPFSPRSSRHNRGSFDDSAPWLKLQEPTSNSHIETGNYEMYKPNKPGIPADW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCM2</accession>
    <name>A0A8H7PCM2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carbonic anhydrase</fullName>
            <ecNumber evidence="2">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_009092</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCM2"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03124">
        <property type="entry name" value="alpha_CA_prokaryotic_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041891">
        <property type="entry name" value="Alpha_CA_prokaryot-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF265">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034333547" description="carbonic anhydrase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="8">
        <location>
            <begin position="46"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2171431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="306" mass="33822" checksum="93765FD98D02A168" modified="2022-01-19" version="1">MKSNILLLLSAVAIVSASCLRDPSVVTHHHKSLTRRNREEGSVPVSTFGYTALKGPLDWYGLNKATNGACAMGTMQSPINIDTDIGLAMEKVVLKIPDVSSAKFENLGTNVEVVVNGTLLVGRKEYKLQQFHFHTPSEHRFFEEFYPMEVHFVLQASGKKIYKKILFEMSTNWTFINDYLDSTIAVVGFVVQLCTSSESDSFLDDVFANIGDIETPGTFTETGPLTFGALEEHLHHNKIFQYSGSLTTPPCSEGVNWLISTEPLQLDVNTYNKVKSILKFNSRYTQNNLGGTNLLEVAAAELATSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD33</accession>
    <name>A0A8H7PD33_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-N-acetylglucosaminidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_008069</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD33"/>
    <dbReference type="OrthoDB" id="64736at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.670">
        <property type="entry name" value="N-acetyl-b-d-glucoasminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007781">
        <property type="entry name" value="NAGLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024732">
        <property type="entry name" value="NAGLU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024240">
        <property type="entry name" value="NAGLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024733">
        <property type="entry name" value="NAGLU_tim-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872:SF1">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05089">
        <property type="entry name" value="NAGLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12972">
        <property type="entry name" value="NAGLU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12971">
        <property type="entry name" value="NAGLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034241300" description="Alpha-N-acetylglucosaminidase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase N-terminal" evidence="4">
        <location>
            <begin position="26"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase tim-barrel" evidence="3">
        <location>
            <begin position="124"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase C-terminal" evidence="5">
        <location>
            <begin position="469"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2171689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="745" mass="84103" checksum="0B8E1FE16201A9ED" modified="2022-01-19" version="1">MVKYSLLSGLALLSAVGHTFGVSTAGIESLVARRLPEYTDKFEFELTDNVSQNSSSSYDEYQVQSTKGRIKVMASTLSGLNRGLYAYLTEVAQTDTYWTGSYLDVNGAPLPNESLSGSSFVKWRYYFNTVTFSYTSAFWSWEEWELQLDWLALRGVNLPLQWLGYEKILVDTFRHVGMTDDQISTFLSGPGFQAWNRFGNIQGSWNGTLPLAWVNDQFELGKKVASRMVELGMTPVMPAFTGFVPRAFVDIHNSSNLVNSSQWNGFPERNTYDTLLEPQAPMFAEMQKYFITQQKKDFGNISSVYTLDQFNELTPASGDASYLKATANSTIESLKAVDPNAVWMMQGWLFFNLESFWTNDRIEAFLSGVTNNQDMLILDLYSEVVPQWQRTKSYFQKSWIWCYLHDFGGNMGLYGNMHNETVVPVETQGKSDSMVGMGVTMEGQEGNEITYDLVLDQAWSKTPVETASWVQAWAKRRYQGKSTTPVLQAWEILRTSVYSNNDTNVPAVPRSLVVVEPATSGLLTSGPRQTQPTVISYDPKVLIKAWRLLVEAATKNPKLLSIAPFHHDLTDVTRQVLANAVIPAYNDLISAWNATSSTGTSVQTAGKKLIQIVATLDKVLYTDPDFMLAKYIKDAVANAHSKSSQAYFEYNLKNQVTLWGPLGEINDYAAKEWAGLVGQYYQVRWQMFIDYLLKTTPDTYNSSSFESDIYNFEQNWNSQRWSGPWTTRGNLLEIIKSSTVLKELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD52</accession>
    <name>A0A8H7PD52_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_008099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD52"/>
    <dbReference type="OrthoDB" id="2328924at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2171719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="33680" checksum="E5F10EA9BC199DCA" modified="2022-01-19" version="1">MVRITDEQIEQWRRDGYVLIPNFLSKEETEAARNGVFEWFSPSWDDYVAAGRKIDKPGVLAFPWDNSGLNKAVLHDDLIDVAERILGTKDIHLRLVRLDEAHLGIKYAGNPSNNSLPDVFHQDWGNNTIGPHHPEDFCSPAFFYCLDDVKPGMAPVQMVKNGLEPNPKNAEKFICPGGSLCIYSTWTWHASSEFEAKEGHRPTMWLGFNRNDRMWEGGRFFTIKATGTRDGWLRAIGEATPRQRELLFLPAVDDEKWTDEMIDGMFKRYGKHGFDPEPYRQAKAKREAQTNGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDA8</accession>
    <name>A0A8H7PDA8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDA8"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055555">
        <property type="entry name" value="PA-PLA1_DUF7131"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057826">
        <property type="entry name" value="WWE_C20G8.02"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF10">
        <property type="entry name" value="LD21067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23465">
        <property type="entry name" value="DUF7131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23463">
        <property type="entry name" value="WWE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="2">
        <location>
            <begin position="515"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="765" mass="86656" checksum="2EFC4C7359BDCD40" modified="2022-01-19" version="1">MSDIPALKHYWFNSVDKPLVDPVQQRIDQHNAHRSPEASRASSVVEPTKPYLQTQKWIRFSSSDNDRLEQAFQAGTPKKVLVNEDQLFEVDIEKRTISAAYWESAVYKVCRASWFTRGKDGSQWMPCDEEFANKIEEGYREYKPWKTDVPDTDSLDSDDKPSYMPGFDGLDTPLSLEDAVTTLPEMKWQLDPPNHDDYIVYTSADTAWLLSDTTTSRITKSIFMTLTNNQNLGGTRLIRGYPEVKPGESVGVTSMGNERSPTSPSTPIGPMTEKETQSEIEERQKQRKQEIEDYENENADKAREIDHLIICIHGIGQKMTERLGQSFVHDVNVIRRTLKEMFPTAIAMTSNPKKKNGIQVLPILWRHQIKFGLGNDDEDEQDEMHRPGMREGQPTIDDLTIEGVKPIRSIVSDVLLDIPLYMTKYREQMLSIISQEINRVFHLFLRNNPDFLAKGGKVSILGHSLGSCLAFDLLTLQPFDAHEKARVNAEHERRHSYVSSQYKPTDILEGIIPPLNFDVQNLFCIGSPVGIFLLIRGSKIASRRMLAEDQTHLESPSANPVCYPACNNIYNIFYRSDPVAFRLEPLIARHFTAHLKPEPIPYHKGGLKGIFDASYTVTSDIANRAEAVLESLKSSATSWFRREEIATSPEGINLTDEPEEITLSTLNINPEKANSEPTSPMISKSDDLLRKAQGSSLKGTGKSKSHMRAYVTGAERLKMLNSTGRVDYFIQEGILENSYLSALQSHLVYWKDTDVAAFLIRSIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDI8</accession>
    <name>A0A8H7PDI8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Probable valine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="4">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Valine--tRNA ligase, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">INT43_001404</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDI8"/>
    <dbReference type="OrthoDB" id="629407at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.380:FF:000001">
        <property type="entry name" value="Valine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000009">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000020">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000078">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000005">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="entry name" value="Valyl-tRNA synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="17">
        <location>
            <begin position="104"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="18">
        <location>
            <begin position="773"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="Valyl-tRNA synthetase tRNA-binding arm" evidence="19">
        <location>
            <begin position="990"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF10458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG2171928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1059" mass="119828" checksum="9359774E940346EB" modified="2022-01-19" version="1">MADNAQQPPQDTEAGQAKTKNQIKNEEKKKEKLAKLAAKQAKLAAAAAQSGDSSEKKKAKKPKAEKEAAPAVEAYVNKTPKGEKKDMSEEMAANYNPRAVESAWYEWWLKEGYFKPEMTAEGKPKPEGLFVVPAPPPNVTGSLHIGHALTVAIQDALIRWNRMLGKTVLFNPGTDHAGISCQSVVEKKLWKDEKLTRHDLGREAFVNKVWEWKQKYGDRIYEQFYRLGSSYDWDRAAFTMDPKLSKAVVETFVRLHQEGTIYRANRLVNWCVRLNTALSNLEVDSKELTGRTLLNVPGYDENEKFEFGVLNEFAYEVEDSKDRIIVATTRIETMLGDTAIAVHPQDPRYKAYHGKHVIHPFNGRLIPIVLDDIIVDMEFGTGAVKITPAHDFNDYEVGKRHNLEFINILNDDGTFNENAGMFKGMKRFHARVAVVEELKKKGLFVGVKENPMVVPVCSKSGDVIEPIMKPQWWVNCKDMANDALKAVHDNKLKITPKTSEGDWFRWLENIQDWCVSRQLWWGHRIPAYFIRLEEQRSDLEESELWVTGRNLEEAQAQAEAKFPGQKFTLEQDPDVLDTWFSSGLWPFSIFGWPDNTEDLQNFYPTSLLETGWDILFFWVARMVMFGIKLTGQVPFSEVFCHAMIRDAHGRKMSKTLGNVIDPVDVIEGISLQGLHDKLYEGNLATQEIETAKAGQQADYPAGIPECGTDALRFALCAYTSGGRDINLDILRVDGYRKFCNKLWNANRFAMMKLGDNFTPRADAKLTGNESLAEKWILNKFNKAAIETNKALEERNFMAATNIIYNFWIYELCDVYIELIKPICDANTEGNEQASIAKRSAQDTLYTCLDGGLKLLHPFMPFVTEELWQRLNRRQGDTCTSITKAKFPVEDKTYSNDEADKEFDIVFAIIKATRSLMVEYSISKNAKVFVQIANCELANTLKDETQSITTLAKGVTEVNIIEGADQTPVGCALATLTEEINVLLLVKGQVDIESEVQKLQKKVANVDKSKQGLLKKMSIPDYENKVPADVREINDSKAKALEAELDALNTSIAHFLKLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDW2</accession>
    <name>A0A8H7PDW2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDW2"/>
    <dbReference type="OrthoDB" id="5594949at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39074">
        <property type="entry name" value="AGAP007547-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39074:SF1">
        <property type="entry name" value="AGAP007547-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="261" mass="30381" checksum="A82D0A573C46B2A1" modified="2022-01-19" version="1">MAYTSAPQALFSKIFSSVLVFGSVYIATAVVMLSIVGFNTIFLDYTPYDPDKSECSCDCWDRKFKGEYYGATRDYKAIYFNMTSQSVHVFMWTLLYILLVEQFVRKCIHHILDRSIRYHILLLAIPGYYGNYYNWWSTWNYLNDEFYSMFSTQMFFNVSEFIPSLSLYFLLDANAKPSKLLTQASIAISMAHLFLSLSDQGWYHIATISGKIQRDIAFIVSDVVLLVVNIRELLKMRALKRDLYQVFAICVSLIVFYHFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEZ6</accession>
    <name>A0A8H7PEZ6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEZ6"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2172663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="30302" checksum="ADEF2D8BF1F72641" modified="2022-01-19" version="1">MPAMQQQQQSQQNDMLGQDRAFPSPMTNSSLDSPPGHGEAKNIMQPFPHMGASQPPHGSGSTSRMYENSYTSQSSQTQPRQIVFKQHRPRQESQDNTWQVGSVDSNGSSYGALGGDNIVSPGSGSAFEDEAQQKKYVGYAKNQGWGRRKMTRLYYAKGVWANLIFNFGFAISQELGSLLPDYDASKSNKGSILKNSVEHIQMLQNDVAVYQNRIHELESLVDSYRTRFGDVNYGGAGTANNQHLMQAQSMSIPSGHPLDMSQTAIPTSQPYRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFT1</accession>
    <name>A0A8H7PFT1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucocorticoid receptor-like (DNA-binding domain)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_000214</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFT1"/>
    <dbReference type="OrthoDB" id="413436at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1480:FF:000001">
        <property type="entry name" value="30S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_uS14_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006477">
        <property type="entry name" value="PRK08881.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836:SF19">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2172864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11461" checksum="AEC3AD0F7F43A0B2" modified="2022-01-19" version="1">MRSRILRDMKARTTVANNELIRQAYRYITRNETLPARTRHQAQLALNSMPTNSSPVALRNRCLETGHGSGVFREFRLCRFQFRLKALNGELPGVKKSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PG41</accession>
    <name>A0A8H7PG41_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_004711</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PG41"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034263110" description="Galactose oxidase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2173337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="63173" checksum="2E912142DC09276C" modified="2022-01-19" version="1">MLLSRSLLIALGGLAEICYAYTAVGRASSMAVLIGNKIFCQGGYTSVQNNNPGPATNEMIILPIDVSFQLNNPPYESDSGTMDGAPALLGQANFLGGYNNSGYYMFGGQIANGTTRTEVKSLYLFNTTHYNWQQNPQTTGQWPEPRDSASGIANIKSGAGYIFGGEPLVSGSNWLFNTTWRLQAGSGWSEIGGVAPGGGRQAHAVVMLTNGQMVILGGADNNGNAIPFNEILIFDTTTGTYTTKNATLSGSNPVPRLAHVAVSSEYQQFFLLSVLDMVAYMFYLLAYDNKIIIHGGTGQNNAFLGDLAVLDMNQTTLAWTVPTTSGTAPSPRNAHTAVMVGTQMFIMYGQTGPSSLDNGVYALDSTSWAWQTTYTPTLAAFAFLRRRRRQSESSVYPVNGGPDSQNVYYANNMFDTAPPYYQHSQFAGSSEFKNTPSQAADMSQINTANHSDMITQKPNTPAHASAEVTHLQKPNGDITYSVMVLMHSCHQNICLAFVVASFLATTWAQSSNGPTVSCGEPATDTTKTPTLKCCSQTNGLVVRDAQGQTSGCVIADYSQPAVASAFQSCCSQQMVIYSAVGKQAPDDSTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGP0</accession>
    <name>A0A8H7PGP0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_005057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGP0"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034626658" evidence="2">
        <location>
            <begin position="21"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2173639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="347" mass="36304" checksum="D390176DB95C51D2" modified="2022-01-19" version="1">MKFTTSLFICSAVAFSAINAVPMEGKKAVAVEVVAKAVGAEQQLWSSKKSKGKGEDEDEGRRKECENQLVTIQLADNATVQIPCRANAFDLSDKCLATAANPSAFSSRLAKAKGGRQQLWSEDNDDDKHDHDDDKHDHDHKHDDEDKHDHDHDHDGEGLDCEDQTVAIKFGNSTYEVPCFSNSIVDVSQPCLEFILLSLPNPDPSVSSAVETATTGTTDPTGTTAVPPTPSADPSSVTSGAPSSAASSVASSAASSAATTTVTSAILTTTEETTVTDATTITSAILTTTEETTITEASTTITSAILTTTEETTITDATTITSADLTTTEETTITETTTPTTAPTAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGU0</accession>
    <name>A0A8H7PGU0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_005149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGU0"/>
    <dbReference type="OrthoDB" id="2420715at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="242"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2173729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="550" mass="63955" checksum="B781A8C811A012FA" modified="2022-01-19" version="1">METRLDSATHDNLQSSIETVTSRLYETTNLNQRLQVVKEKLTTRSFLRKEVKHDSKHNPQVLSLIDQDIKSLREEERRLVEQLVQANKSFLKQYKKVVVALSDSERGGRLQQDLERAFNQKIQDGFNTLSKSTSKETQQTLDAYTQHSLRELDNIKTTSTNLETRLKQHIEDCTKTFDTISSDMRKSSRSTSSSSEDYPIDRRLMKDVKEFHKYLKRIDTEGKGIANNNSLDIVHTRSKKWQEETAKQIDLLHKRNEDLQRKSLQLENITRDYNRRSSEIDIVYDKIKAQMETLKKESENKQARASNTNDTQHDITDIRTQLAELKAEMSRKVTDNDTRSDIESGLSYSNGTMDFKALQILESRIIILEQTYKFKLKELEDTIKDLSQERKDGDKNDNGKRPRTHDLETASSEIKLQMDKQAVQIKELMAFLEPLRSTVLGNTFAENLQTSMNQLIGVARRHESDIDHIYTALKEVAHAMPKEKPSNTNPVLELTLKAQVNTHERRVKEKHTLIMETLEDFKSSFTKSEEKQQKQQIQIDNLQQQLSLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PH21</accession>
    <name>A0A8H7PH21_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_005257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PH21"/>
    <dbReference type="OrthoDB" id="2323195at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2173837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="134" mass="14219" checksum="B7CC9127DCB18A46" modified="2022-01-19" version="1">MYLTVTISVHQIIPIGREGSTDAPITDLPCNKLAAGDSVATFVAGAKTQLAYSITEVHDATSTCFIDIASGSGDGSFTKIATLEQCASYLGTYVANVNFPTDITGNATLRWWWHVQSLNVTFATCSDITVVHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PI04</accession>
    <name>A0A8H7PI04_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PI04"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF3">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="16"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2174281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="345" mass="36946" checksum="9E3D0C7CF933B6F8" modified="2022-01-19" version="1">MLAATLVDEAPANAAETNYNFSVKVTNVDTPKPAGDQVQVKLQACSYNHRDNWIRQGLYPGVKSGSVLGSDGVGVVSEGDDALTGKQVMIVPGQGWDSDPRGPEGRYGMLGLLPLPGTWGEYIVVDKKDVVQCPPHLSTAEASALPLAGLTAYRATFTKGQVRKGDNVLVTGIGGGVALFALQFAVAAGANVYVTSSKEDKIERAIQLGAKGDNWHKDLQTLLGKGQINTVIDGAGGKAYNVYPRVMAIGGIVVNYGQTSAKDPVTFPMTYVLKNIDLRGSTMGSRQEFYDMVEFVDKHKIKPIVSQVWQGLTESNIEAAFTVMRNGEQFGKLVIELADTTHNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PI22</accession>
    <name>A0A8H7PI22_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_004334</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PI22"/>
    <dbReference type="OrthoDB" id="26740at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21675">
        <property type="entry name" value="SMP_TEX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF19">
        <property type="entry name" value="NUCLEUS-VACUOLE JUNCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="286"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="541"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="596"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="758"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="596"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="641"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="664"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="787"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="817"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="896"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="922"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="942"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2174311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="994" mass="110910" checksum="67CEC2388C3FB21B" modified="2022-01-19" version="1">MFCALTPKKGCFQLVAISVPFASQISSHKMVSFKIFLLIYFFGGITLVPIGVGIALFLIWLYHQYLPEVFHSKDSNKEVLLSEKEGYVENSQSSNRHYRSGWLRIRTEYEPGDSVSSIMSGIQSYVSGKSVSKRREKYFAVLKFGTLFLFDNESKEDCRMVVPVHNYKASIYPENLLDHEVYAKPNAIKLSLIDKKVDDDHMTLQSAPAAGRRSSSNEEEDISLENTLYVFCDRPVDKEDWFFAFMDANDAMEMDTTNPFVEYVDKTRLDQIALNQLIKTVQEDSSHRHAQWLNAILGRIFLAVYKTDRINELIYHKVSKKARKVKRPGFLGEISVQNVQPGHSLPYITRPKLLSLGQNGELQAQANIHYAGSFRLEIATDIAWSYSSKMKPIKVHVELAVMLKKLTGKVLVKIKPPPSNRLWIGFYEPPQMDWIIEPIVSDKPIKLSMVTNAIESKIREFMVENMVLPNMDDFPFFETDGLGGIFGEKVEKVRRSKSQEAAEATEVSNNVEKIAQDLQAESSSATASSLFDEDDRSVLLGDEPSLRNRHRSNAAEDASIASNRKLKTRSATDKDFLHSKDPLLGTNLLNDRSISKSTPNLLGGQTSLVGHTSLSQESHPGSSDTASIKSFESLESEDDMKEPAQENDASKRWSNTIAKLKKSIGKDSDAGSTKEDKPTRNLSDSDSIEASNKPRSRSSTLSSSDGKNRNSFISRMNGYIEQKLNDENETSTIGSNDGASKRAALRAKATTFFSKGIENMQDYRERNQDNKSVQLLEKFGGKGRLRSISSASDRPSSVSSSELPPISPSKPPRQHIDSSGTAHVPQSPTKPIASSKDHQRPQNPTAVPVEHKPALSPAQQYKQFVYDTLEKRDDVPADQSAIQGKPESVKEVQPTEDFSNHISQSSFVPSELKHAHTVPVQKPRPVPPPPVPPRNLDAPASKITNNEAQVQEANPEPTNQALPKKPEKPPVPPRSSEVQKRLTKPVLPPRDLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIJ8</accession>
    <name>A0A8H7PIJ8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_005777</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIJ8"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051704">
        <property type="entry name" value="FAD_aromatic-hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865:SF2">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="5"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2174719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="409" mass="46017" checksum="E8CD85421E690A73" modified="2022-01-19" version="1">MAPLKVLICGGGCGGPTLAFWLSQTGHHVTVVERFPALRASGAQIDLRAQGIQVVKRMGLLDTIRSKVVDEEGMSLVDSNSRAKGTVLANKSGKGAQTVTSEYEIMRGDLVRVLYDATKDKVEYIFGVTVEHFEQYEDRVEVHFSDGRSDTFDLLVGADGQGSRIRKAILPADTPEPYKRLGVYMAYWFVPRTEGDSNFAKAYHATGSRMIMSRSHNASDTQAYFTLRDDSEETRSIPKAPIEQQKEFWAQRFKNAGWQADRFIEGMKTTKDFYCQEIIQVKTDTWYKNRVVLLGDAGYCPSPFTGMGTTASFVGAYVLAGEINRNSENLPEAFANYKKILKPFIEEIHSVSPTFIRLFLPETQLGISILHFIFGILCYLRIPEFAARFSSEERGGWKLPDYSEFEIHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIW9</accession>
    <name>A0A8H7PIW9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="3">5.1.99.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_005860</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIW9"/>
    <dbReference type="OrthoDB" id="10064708at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000005">
        <property type="entry name" value="NAD(P)H-hydrate epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032976">
        <property type="entry name" value="YJEFN_prot_NAXE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232:SF10">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="10">
        <location>
            <begin position="7"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2174798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="221" mass="24292" checksum="CB8BDBAF6AEFDC54" modified="2022-01-19" version="1" fragment="single">YITQKVAQAIDEDLMSAAGGFSVDQLMELAGLSVAQAVQKTYPRQKYPRVLVCCGPGNNGGDGLVAARHLFHFGYKPSIFYPKQSGKDLYKRLVTQCNNLDIPFVDQANTEQTDVILDSLFGFSFSGDVREPFKVVVSNLKSTKVPIVAVDIPSGWDVEKGNVDNQFFTPDTLVSLTAPKLCAQTFKGRHFIGGRFVPPSLAKKFELQIPEYPEGDQVVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJ86</accession>
    <name>A0A8H7PJ86_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SGF29 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_005945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJ86"/>
    <dbReference type="OrthoDB" id="10265994at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20393">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20394">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047288">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047287">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="6">
        <location>
            <begin position="137"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="104"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2174883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="277" mass="30471" checksum="765E357B9AC69A30" modified="2022-01-19" version="1">MDRKSRASRAASLDETNEEVNLWKQICSSLLKLENVQKESESIVTSVNKLHMSVDGGEGMSSSTSYKLKELYSEGISASSTESKTITDVIEKLSVLIALRNASENTSDPRRKKRKTEADDLKITSGPHAAKKSKLQNGGIIPIGTSVAAKQPKQKDKTEEWILAAVISYNSDKNKYHVEDVDQDETGTRQKYLVPPKNVIPIPSVAEVRQMPEISAHTDVLALYPGTTCFYNAIVITPPSKNKDAASAGCYKVQFEDDNDETKVVTAIHVLEKSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PK29</accession>
    <name>A0A8H7PK29_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_001119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PK29"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="234"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2175472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="455" mass="49863" checksum="F50E01A7599D2CE4" modified="2022-01-19" version="1">MGSSASDKPQSTGCLAALFKSRRKNNKTPHYQEKVTSERLPPPYEECVATKALQHLDIKIDSEVERLVYKTIDDASDELRSVSLELHRNPELAMHEYHSHNLLTDFLERKGFKVTRHAYGMETAFTAEFTNGPGRRVGLCSEYDALKGLGQGCGHNLIAISGVGAAMAIKAAMESGKVQGKVILYGTPAEEITVGKVVMCNKEVFKKNVDVCMMIHPSALDTVYHHMLAVDHVSVEFFGKPSHAAAAPWDGINALDAVAQVWNSISMLRQQILPTDRIHGIINDGGKAANIIPEYASATFFVRSLKISQLEELKPRVEKCFQAAAVATGCKVKWAWKDVGVTKDVLPNSVMGDSYIKYMEKLGIEFMPRAKQDELSGGSTDAGNISYQVPLVHPGFGIHTTASNHTHEFTAAAKTEAAHNDTLRATKAMAMTLVEILQNQCMLDAAKKEFDETTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PK80</accession>
    <name>A0A8H7PK80_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TH1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_001098</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NELF-D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PK80"/>
    <dbReference type="OrthoDB" id="511287at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006942">
        <property type="entry name" value="TH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144:SF0">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04858">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2175451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="570" mass="64935" checksum="410D01E601DC6312" modified="2022-01-19" version="1">MTDLQDKEKLLEQKHRALASQDSILEPKINEVLSDFLTLGGRPMDVVSCLSESYVGLPTLCNTASEWGQELGINSKDLMRDVIKGMLIDRFDSTAVDTKFMGAETRPPWLDAMIQDPYWRKVLYELSEKHQRCDLLNLAIQMIADAGYQGEIVKVASASTYIGVFNDVLKDSLERLLQEDDVGLDENLPDLIRVCCQHEQTYLYSQLLLKRLADQPGGEPYRRISKELETNALTKGDEHLISILRTYLWEFPQSLASPITAILQNSHATPGDIFAIYRQYTSANPPPVRFLCDSQLLDILLKAVFVPRLGQTPKPEIQEKIIYLIAYAVTVNDSEGKDTNEINSISEKLKLLSTTLTKRTTGANMPGAITTILDLMDVPIVSMALLYWISYLLTETSWYETYYRSAVVPVPHQILEEIAHRHPLQRPFVFEVLKKNLTVEVKNLSPEIMMALRKTLLDRMIYLAQLGFVLPVLKYIKRISSSIDESLIVHTLKMILDMAEPPYSDEFIDLIVEIVEPIAESLNKAMEVKTVVWEFLILRLCKLSSDYALNRKEPINADTRETIMSLQRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKL7</accession>
    <name>A0A8H7PKL7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKL7"/>
    <dbReference type="OrthoDB" id="3863715at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2174946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="221" mass="24160" checksum="990B284C0F5FADDF" modified="2022-01-19" version="1">MYPRRTCFKCGNGKWTIQHNTETLSFIINLAGHFAESCPEPEKLCYNCKKPGHQSTDCTEPKSVQSKQCYTCGGVGHIQADCPSVGRIPAPNAGTGRCFTCGRFGHIARNCNQTGENGTNSYPRNTRYQNGVTGGSNFRVICYKCGGRCYNHFAKDCQANGVKCYNCGKFGHIVSEASDARSCNNVSGGEQNSRTCYKCGTKGHIARDCPENNATIIETYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKP0</accession>
    <name>A0A8H7PKP0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_001117</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKP0"/>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2175470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="283" mass="32358" checksum="44C92F42E7A4DA0D" modified="2022-01-19" version="1">MDVSSALEAHQNKFKSIEVEKLVPVEFDLNLLAAFDTNAIDEKKLSSKKENYLKELNRDNAQLLFNQIFKLPVESTDAGLLAKLPESSHILPREKALPKAKPMTRWEKFAQIKGIQKKKKERMVIDEATGEYSPRWGYGGGKKDKTKDWLLEVPSNVDPMEDQYAKLREEKKERVDKNKKRQKRNEEEASATSKGQDPRQVKKKQLQDAIAVTKRSTASLGRFDKHIEGEPKMKGMKRQFAPNITDSKVEKQASMDILNKVVGKNGEVLNVQKAVRQSKRARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PL19</accession>
    <name>A0A8H7PL19_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Late embryogenesis abundant protein LEA-2 subgroup domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PL19"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117070">
        <property type="entry name" value="LEA14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2175690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="33810" checksum="48A7FA0894C2F506" modified="2022-01-19" version="1">MSVFEHDDYYAPPRSRPPPPDPPSHNINYDAYPLRDTTSEKPPGSPYQFQDHSRVSMADDNSYSGWRGPRDSMSDLKLTQHAGYDSDEEDFGQIPRERKKRTCLDLICCGCCTCCPLWARWTSCGCLIILVGLGIAIGVLAGTFKMPQITFNGIADQNFATNGSAFNMSANILITINNPNIEAPTFESIKATAYYPNIAQSVGGGQLNNVHINAKGLTNVTFPFSIVYDPSQGSDQSMLYDIATKCGLLGQAKQDITVNYDLALTLKVGVIPITITLPEKASFPCPVDNGQLPFSSSDLPSGIAGAIPSGVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLK1</accession>
    <name>A0A8H7PLK1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase S59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_005374</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLK1"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2360:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein Nup98-Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1610.10:FF:000003">
        <property type="entry name" value="Nucleoporin SONB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21240">
        <property type="entry name" value="Nup98_GLEBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="11">
        <location>
            <begin position="796"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="258"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="381"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="8"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="423"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2176141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="938" mass="93385" checksum="0A1A10A1278E9535" modified="2022-01-19" version="1">MFGGGSAFGSSAFGQQPQQQQQQQQTPLFGQQPQQQQSAFGGFGQTSAAPSAFGAANTGMSGFGAGASNPTSAFGGQSAAPAFGSANNATSGFNARPSAFGSSAFGSTAATQQPASSGFGFGSSSTAAPTFGAAANNATSGGLFGSRPATTSAFGSTAPSTGGVFGSTPAASTGYGASASTPFGSTGTGQVQGTVNPEFTATVERDTSTGVNNQYQTITAMPAYRNYSVEELRVQDYQAGRKNAGNAAAPGGTFGSTGGFGAQASTPFGQSSAPSAFGAQPSTSTAGSAFGQSTGGFGQSTGAFGQSAPTGGFGATNTGSTGGLFGQQPASTASAFGSTPAATSGFGGSAFGQPQQQQTTGFGSTPAASGFGASAAAKPFSFGQTPATSQPATGFGATGSTGFGQQPQQQQQQPSVGGLFGQAAQSTPSFGQPQSTGTSFGFGAKPATSQPATGFGGFGASTANKPATGFSFGASTTTTPSATATSGFGGFGGATGTAGATGFGSTGGATGGLFGAAKPAASTGLFGNTQQGASTGFGGFGAANTAGTAGTGGLFGAKPATTGLSAPLSFGAGGQTGGLFGGQQNTNATGSFNLPATGGLTTFGTTGLQQQPNANQPPLYASLDKYPYGYNPLFENLQASGGTAERSSSVAVSEEPSKKLSTTPHFLLTPRAATRIKLRGYSFTPAGEAVTRKTSGLDGISDEAVLRPEAFAPRPSIKRLIVNKKVSPTDVSNAVNGDNGVLSSGKKSKALFDPHLEMIATQHGVPGAAVDGDRPQAAEPAKNVNRNTAFSDEAMSQGYYIKPSLQTLGNMSIQELKKVQNLVVGLKGVGEITFDGPVDLSEIDLDQIMVGIVNFQLKTCTVYPDENAKPPRGKGLNVPATIKLEKCYPCDKTTKQPITDPQHPRVIAIIKKLREVPETEFIDFEASTGTWTFKVQHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMZ2</accession>
    <name>A0A8H7PMZ2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fructose-2,6-bisphosphate 2-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_005623</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.46" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMZ2"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000005">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="9">
        <location>
            <begin position="2"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="454"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="455"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="208"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2176389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="492" mass="55934" checksum="3EE89898456DB702" modified="2022-01-19" version="1" fragment="single">TVGLPARGKTYIAQKGWVGIHTKVFNVGDYRRKLAGSHVPHTFFDPHNSIGEAQRQQAADQALQDMINFFVKEGGIVAIYDATNSTYKRRKWILETLAKHNVDVLFIESICQEDEIIMSNIREVKLLSPDYVHVDPELAAEDFKARIVHYQEQYETISEERENDISYIKLINVGHQFIINMIRGYLESKVVQFLMNLHIVPRKIYLSRHGESMYNVEGKLGGDADLSPRGQLYAQQLPSLVRRHLGDQPLTVWTSTLKRTIATAANLPYPKKTWKALEELDAGVCDGMTYEEIEEKYPEDFANRDEDKFNYRYRGGESYRDVVLRLEPVIMELERQENILIVGHQAILRCLHAYFFHDRHEDLPYIKIPLHTLIELTPRAYACEEKRYPLNIGAVDTHRPKPSSSPGLGSLNTNIRTTNAGASGEIVKAPMSPILPISPKLFPNIHRQTPMTARTEVKTNIEQLSRDPNDARSPSTDMTALDLGPAASISSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNP7</accession>
    <name>A0A8H7PNP7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_007771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNP7"/>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07516">
        <property type="entry name" value="HAD_Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10000:SF8">
        <property type="entry name" value="HAD SUPERFAMILY HYDROLASE-LIKE, TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10000">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2177115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="285" mass="31516" checksum="5597B48A67AB77BC" modified="2022-01-19" version="1">MERPAATKPVLFVTDLDGTLLHTDHSISQRTVKALTRAQELGVEVMIASGRSPRSVHKVIDKLGGLIPDLTLCCNGAIVYDAKHRRVLQKDEIPADVAKTFIKDILKIIPNAGIACEVTTETGTDFRCNEEFRRVREKFIYYDIQVYEDSLAMLNDVEGSNKILILCEGWAPAEMYAVCPQSYLDREHSPVTISYSNSFQLEVSAQGVTKGSALSRYCEDRGITTDQVVVFGDEMNDYEMVAWAGTSIVMANGSERTKSVATKVTVSNDEDGVAVEAEAILDKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PP24</accession>
    <name>A0A8H7PP24_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_007967</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PP24"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000007">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="11">
        <location>
            <begin position="121"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2177310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="326" mass="37371" checksum="F83E8FD290280E87" modified="2022-01-19" version="1">MADPVDVDVDNIIERLLEVRGSRPGKQVQLAEHEIRFLCQKAREIFMSQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLSYKIKYPENFFILRGNHEYASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLQSMEQIRRVMRPTDVPDTGLLCDLLWSDPEKDITGWSENDRGVSFTFGPDVVSRFLQKHDMDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDQTLMCSFQILKPAEKKSKYANMGGQAQGAQRGKKKKSIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PP91</accession>
    <name>A0A8H7PP91_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DSBA-like thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PP91"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="17"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="223" mass="25270" checksum="AE95583461C4994E" modified="2022-01-19" version="1">MQYSRPFIRKMSSTIKIDIVSDTICPWCFVGKRRLEKAIKNYQTVNPGAKFDINWYPFELDPTLTREPVSKVERYASKFGAARSKQIIEHMKSIGKEEGINFDYGGVTASTIDSHRLVEWAKEQGKQDEVIEELFKLYFEETGNIGDLEQLAGVAERIGLSKENALEYLKSDKGVKSVKEKIYKSQVEGINGVPNFTIQDKYTFSGAQPPEAFFNVFQKAASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPA1</accession>
    <name>A0A8H7PPA1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_003146</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the carbohydrate esterase 1 (CE1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPA1"/>
    <dbReference type="OrthoDB" id="2425929at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF1">
        <property type="entry name" value="BLL1128 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="1 4" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="20"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2177899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="360" mass="37388" checksum="D40DDC3F2EF62831" modified="2022-01-19" version="1">MSAQQELSKKRDRFYLVSHTRTGLTTKTTTTTTTTKTTTTPSPTTTTTTNTGTPTSATSTTTATGTIPSATVHPTATPGTWQTFTASGSSVQYKVYTPSKYSSSQKVPLIMMLHGCTQNMNIFSDSTQYAGLAEAQNFIVVFPSQSTSVANSCWKWYDPTSQKRGGGDAAVLAGIITSVKGNGKWNIDNSRVYVGGLSAGAAMAAVMGATYPDYFTAIAVGSGLEYGAGTSASTLSLTQGGPAPATQGQAAFNAMGSYARSVPVLVFHGTGDYTVYPLNGDQVVEQYLVTDNLAAPNSGLNTAFGGGASSTDHGGQDITGSTSKSSGSVSGGYTYTVYTWNDNAGARVQYYKIDTMVGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPP7</accession>
    <name>A0A8H7PPP7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cyclosome subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_003135</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPP7"/>
    <dbReference type="OrthoDB" id="2504561at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037679">
        <property type="entry name" value="Apc5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830:SF9">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="9">
        <location>
            <begin position="270"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2177888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="485" mass="55619" checksum="89C065BFC4DC06AF" modified="2022-01-19" version="1">MYEQLILHSNYLTPHKLVLLVILTKFCNYEYTGIAVHKIICYLIDSIQHFDDYKEPTLGQVMVKLAAIENEADNMSIVDPVRERISQIQNPESIDQLIGSLMDLLLDNEDEEVDLLSHRHGSIDYILQSVTNNICLSMYQSIPDKMVLDNHSVFGMFVRRCRVEYLKLSFEKTSELFAMFNSYRYGYASFMSSQPDEQSMMGKKSALDSPLDINADYIGGWVSNHDMARFLDREAQVLDKNGTSRVKPFELHDRLAFLQRHAPELVKACHVRFLSCIRIGEYEGAIENLHRFFDFCLLNRETPLYQYALLNLAILEHKFGHRQKALAAITEALDVARENHDEDCLSQALSWLTFIESKNNSEVTQKFFFGENQSKNKNVAFLKSMDMLWDIKRNLQHGDAPRKVHENLIATSAIGTIHSLDRIFEFRNLLAASNWNQHGISALVDYYIQASVDIANEDTPVDQIEVAACMMAMQVAADGVRTYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPT0</accession>
    <name>A0A8H7PPT0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GIT Spa2 homology (SHD) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPT0"/>
    <dbReference type="OrthoDB" id="5588096at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022018">
        <property type="entry name" value="GIT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013724">
        <property type="entry name" value="GIT_SHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039892">
        <property type="entry name" value="Spa2/Sph1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056439">
        <property type="entry name" value="VBS_C3G9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601:SF0">
        <property type="entry name" value="PROTEIN SPA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601">
        <property type="entry name" value="SPA2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12205">
        <property type="entry name" value="GIT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08518">
        <property type="entry name" value="GIT_SHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23742">
        <property type="entry name" value="VBS_C3G9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00555">
        <property type="entry name" value="GIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="3">
        <location>
            <begin position="90"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="3">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="639"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="273"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="677"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2178032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="812" mass="90866" checksum="7B31CB8513B9FB68" modified="2022-01-19" version="1">MSRVRSPPISPATDDLDHQSQFSRTYSTSSSRNTHHSRSHSLASSNGRHNSISGNMEASARVFHTELKAYLASLLAREAAEGVSPQRAGARSKLTKLSNQQFHELSTDVYDELMRRNADDKMGMVPFLPVRDDFHPKRNQARQKLATLPKTRFKDLASDVFYELDHRFPHFQDEEADARPPLPPIPPTANGHMSKNISNTMAQPSQATNIVPVMGTMNIEAVDVGYKYQGNSPINSPFSSPKPPYARTDLDMNPSPSSLSSRADSYSSKDGRMNGNSNNPNSRSPAPGKWDSPVPKKAPAPSSNNSNPNGDSTNFQSLDSLMADLGNMVTKDQAKPREDMNGDSEIRRDIEAQMEQLKSDYEYKLNAMRQRIKDLETDATEREESHAQELQRRDATKEQESQFSQLQEQYDELEDKYKQMEEDYQQQQEVVNDVRREVNNLLEELKELSRKNDEITIEKEQALDKLSVVEKESKEWQRKFEKAKTELRNLKATSSFVRQPPKVEVLGDDLLRPTEDGAISQDHVINYQVAVDDLLRSGRSEKPSTVLIAMKAVVVSCKAITEDVEAYENDESKEINAEKKDKLYTMKSQFSKGLSNLMAAAKTHANGMGISPVSLLDAAVTHLTSTVVELIKLFGMKPGKGSDRDSKDGISQHTSPQNSILRKTDPYGSIYSKPPMHRQDSDAPRGLHPDDLAAYLKKQTDQIVQTIQQLLSSLRTPNRSDEIAPIITSIITVVNNVTTVSKSSFTTSAGQQFKKDGEMILQDLQVTRSKLTALRDGHFIQNPLDAPANAKKDLAKESYEVAKFTRELLGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQB3</accession>
    <name>A0A8H7PQB3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clathrin-coated vesicle protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="192608at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25468">
        <property type="entry name" value="HEAT_HEATR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1829" mass="199860" checksum="85CA43D1B042E97A" modified="2022-01-19" version="1">MPPANSTDSTAGIPDAFLFDESKLAATGNVEKQELYVFQWLSHVEQESKVIEADLLKKIQPKLEKTLLSFVTMASPKPRRPIRCLIGRCFILLYTRAETRTLFDTIVALHGTAGAGKNVDKEAKIAAIVTIGNIMGVLGANILSLFTESANIMLKIIKNSNNSLLMRLESLNALTLLLKGAGKAAGDPTLKELHKYLKTGLVDKAQVIRVASAQCLQACLQNAPQNLTLHDIEQMLQALFKALEGSTFPVRRAVSSALSTVLAFTQSKATVDPSKPTVKRISTAIPTDLSAVPEDVASKESSLLSIEQMLSQLSLTYNRISTPREVKAGVIEAYAALFIQLGTRFVETNYAIIVKHLFNDLLGNIRNTINQSDATFLREDLFFLLNDVVGCRLLSEQGQANAVQVLVNDWIKTWPALMPNQATPNKQCLIMAINLVSSLTNELGGAILPVENILLTPLTTLLAYPSFAVQAATARCLRCVCMAVPGNIGGLLSNLFGHLEKDLKNLTNPSATDDLFKRTIGYVYGVSAVMSVYPYKTIYIKFDHSQRAFSLSSQLLDNLSKNAKVASVQVQVAWTLISSLMGLGPNIVKLYLTQLLLIWKNALPKPTGKESNAIRVEAEWSYILHTKHCVVTSILSFLKHNSRSLVLPETAKRISVLLNNTLAFLTTAPLEFAPTTMSPYLPYETKLTDQNYQLRQRIFECFVAIKPSTTYESLFSSLLRNSVSVFASPERIIPSSGAQVHVTAAVPGQYVSIWNNADGHGFGVTSKLNGFSVNVAASATDHEQDESRNKSWMTRDRYKKVESQLEQPIMGSLELDPLCIYSTTASAHSKHKPQPVSPSTAYIDASIELFATLFPLQSPPVQESILEQVLKLIKEQKGEKNSPKKMAVLVNVVVALLGAFKNTAPGSKKAAGPSSNIAAGRPAQIAQEILQEAIIHPDPYLRNVASDALGRLVNVVGSSLMSSQIQYLVDLVVNNRDPDARAGCSLALGYIYSHVGGMAAGNHLKTIVGILCSLSSDPHPVVHCWALESLTMTISAASLMFSGYVSSTLGLVAKLYLVETHEPGGGSTAVSNAGLAVGFTAYQEFGRIIYELIGTLGPELQAMSKVRELCINIVEELKLESDERVNMEAIRCTQQFIMFAQSHVKLKLLVPYLQSQLSSFHLPLKKAAVTCLYQLVQRNAQAVFKTANPGLETELFSLLDAEPSLTDVKDVIRSWLKETAVKEPSVWVNITKQVLTGAVTSASITKTSETRKSVDEINISDDFDDFDDDDEDGFNDEDGNVDITTSVADSSLGPQTTIIANVDIPPRWRTQLFSLVCLQECIEIISTYGGREHFDLILARRKRQQAGVGDYLVFRVGDLIKLSFTAATAPVNELRLVGINLLRTVIEKFASTADPDLEGTLLLEQYAAQIGAALTPAFAADSSSEIVSAAVRVCAVYVGSGIVKDLYQLGRVLKLLTSALEKCKDDTDITRVGEIKDISPHASIMVKLSVLNAWAELQVATVHQDYLRQVVQPNLPILSPLWLSSLKDYARIRLESDVLALAAGSEGVKATSSGGIDSMYSAATKEITLPFYRKSWLKIMGAVATLMESRDPSMIRALEDTSKEEEEGKNVQGNQGSPLFYVLFGLCIESLARVSSSSGSRSDAVMTLHICLNSLKTFVHPSLAGQNFVPKAVFLELMNVFDRLVQTEGTQVQLEIVQVTDRIVNAYGSKYICDDLDADGLEVSDFEALDRELDPESFPTNAKLYYLYRLLITIIVQKIPALSGRQSQKKKPTQAMDQQTVAVLSVCLDTLGSLVSIAPPSYKCDLFAISLYIYSGMLYHEKSRLAVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PR90</accession>
    <name>A0A8H7PR90_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PR90"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21075">
        <property type="entry name" value="DBD_XPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="81"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="828" mass="94117" checksum="516CDB2ACB4CE1EA" modified="2022-01-19" version="1">MPETRLQKRLRQSDEALSNKINLHDSISGNTENTIGKKRKTTIRQDNKKTSRRTKEPCKKTRKSKIASSTNQDSASGLQCASQLLRLPAEILWSIASYLKPSELCSISRISKAFKNLVDMLPIWQQICTSLALGKPARKYKTYYALATTQMWRICDVCLTRTKGWGSDSPLKIKDIYGNDIGRLCCKCRCSYYKQNPEPVALVWNGDKQIDPCSQVTKSTATFHYKLPTHHLSSVPVDLVDNPHYSNAAPMQLYLESDVVDAARKLHGGDIGIMKAREATRARGIRMRETKRKKIQERRETLNKIIIESGLEHHRNSQVCSNFVSGHMTVDQLVKNLQARERQSQAQDSHRSLVRKELKSRGMPALIDQWEIEHYIREGNGCMEEIIQQLVNREHELQRLATARDARRSFVQKELESHNMPTLIYRWEIERYICEGKGFIEDIIRQVVDQEHELQRIGTVTEALKVRLNQIDNTLAGQLYLYENIIKDSSNDIESLLATIVNAEKDRKAKQAYKEEGRKVKQERRCLLIKKLSKQNSQFSINDARCAHYIAIGAADIKMLVQAIIDESNKKHRTSELEGCLMQHGINHSTNALAKLYIDLGEPELDVIVNAIIEETNESELRRNLLKAKLIESNLRIPPGDALCQEYIDGIFKDDIDTVVKHVANIPYEMEVKKTLQAKWLSNLSAHVFSMLLKHATYNSIEKWQSLLDTDDLEAEWIATQHLNQIGKDQNLPTQWYLELSSDTIYANAISMSSTVFAETSASCYSSDSSGLDTSLDLKTGASSNCGINTYLSETSSRSSVISKGSERLSDTLCQALGTDWLRQILKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PS53</accession>
    <name>A0A8H7PS53_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003499</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PS53"/>
    <dbReference type="OrthoDB" id="1922977at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019607">
        <property type="entry name" value="Putative_zinc-finger_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039278">
        <property type="entry name" value="Red1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21563">
        <property type="entry name" value="ZINC FINGER C3H1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21563:SF3">
        <property type="entry name" value="ZINC FINGER C3H1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10650">
        <property type="entry name" value="zf-C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative zinc-finger" evidence="3">
        <location>
            <begin position="792"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="528"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="483"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2178246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1237" mass="137616" checksum="30BF1CE4F5610B5C" modified="2022-01-19" version="1">MRDLEALRAAALQSLRGDSQDAFTQDLADGAMTARSHSGNLAEHVTSQDNAIGLEMHDISQEAMTTPLGIFQNIRQSNYDHKTKAAVLVTDPSVHEKLLSLSSMGVGSDELINFGFDKLTVIRFCMEENLTLPSTIPKASPDITTSTESNIDHSKQNAFTSEIMVDANNQQSPTSMEEELQQAADNDSESDMEISDASDHEVADDADVEDMDVEDTIGTSKIIMASPDSVLTPASSAGTSPMFLESATPKSDISSFNSTLYPSLPSASATVLDRTLPHKALLEERPLPLTINVTSESDFATEMAYKLFAPVIPALRQFEEKKSKKVSAKASSTNGSDGTQTLQATIKQIADMKKMIEQLEQSKRKDKANISDSSDSPSSVGIEFVVPENDSHIDSVDETRKENQLHQDMEDTRAELNAQAKVVVNNASDEQLSALKSSNDKDVTQLVESVEQQMQDQHSQLNAAVSSTKISSLAGRSEITEPSAISNVTGSASSANTTGVISPPSNTPETKENQASALESPATRDSPLTLYEEQLKSLQQLEEEQDQALQQLELKIAEMRKQQEEMALRKEQAKTKALGVRAKLSMLQRASASPKIRTPPLADKEVQPMQIQQENKPSFVRKELSSYEDSSSSKRTKYNRLPEFGSQFTIEYARDVIQSVIHESGRNVPLLNSVQSVVTDIANRRNARPSKLQDSPRYTDSRHDHIRILNKPDDMIKHFRNIPPAHDESSETVMSKHVEISEHLKDTGRSEGSSNFSQYQSPLQCFRSFQYFGGKSGQSMAYSNPMDTSRNFCAFELAGGTCNDDTCASRHFYDFNMTEADVIQDLLTYAENESEDIRNTYQRSLKRIFASMSAAPNATPNMLVRTAADCRNRLAKDNSRKVSFVPSTARRMEKVKRKTAQHHAKPMQQRQPITSALQPILSSGSPSGEVRYFDIDERNYPRDPKNIQGWIRACLEALPSTNFSDYDITNSKSLELGKAINVLRQALARNPTSELLWCLYVELWLYRGDTKMFEREMEQAVRNVPHCLDLLWYKVLIAPTVEDRITVSDQLLEYFTTDQASASMDALEISSTLLEILCRQAAILIGNDRVRMAKQLLGGVLSSSSAVRAALSIRDQVLLGAGYFHVCAYGRLPTIIFRHHFAKRYQSDEKYIIPLFIVMWNEALASSLEDILCMIIFERQLGTTLSDASDADRFLFLVVLGNFLEFLTGYPQAKGSDIAFIKQRLEESNFLPMCTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PS65</accession>
    <name>A0A8H7PS65_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_002073</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PS65"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21383">
        <property type="entry name" value="GAT_GGA_Tom1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16980">
        <property type="entry name" value="VHS_Lsb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF1">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="4">
        <location>
            <begin position="24"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="5">
        <location>
            <begin position="171"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="265"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2179223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="41969" checksum="DE3EA3D483AD6164" modified="2022-01-19" version="1" fragment="single">MPIFSKKITPTSITSDIGAFQQRATSPEQQELDWGLVVQISEAVNNTELGAKEARKLLQKKTVSGNAQTQALSLQLLKALSEASPQKFHDQLIAKSFIDDLNKLAFYKNLEPQAHGALIDALRSWASQYRQDSSMDELIRIHDKLTADPAGHRMRPSRRERTGTQESSAAPREEDIPGDIELARNNCQVLAQTLSFTDPGKEDISKNELIQEFYGKCKDLHMTIMRHLQTASDPDVISTLLDTNSELVNTFKAYDDMLEQSALQNAKSASTNNDVTADGEGSTQQQTAPTTHEAGSGETRGDIHGEAHGETHDLPPPENETLIDFNTPTREYPPSHTGQGQQTTISGDPFDPFSDDRQVNESQSSVQTGANLPPPLQPRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSV1</accession>
    <name>A0A8H7PSV1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_001756</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSV1"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="103"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="105"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="258"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="166"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2178909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="365" mass="39692" checksum="B9B475A84DFFE351" modified="2022-01-19" version="1">MYSPYIPIFTSQQARSVPSGYRHEQHLYGENVNLMSRAGSRPQQLMKQSYHAAHNSSLPPIPPNVHCGANNNLIYDFGAAAAAAAAAASANMNDMQYGNLNIDRGVKRRRRLTQEETSLLNDIFERTSKPNALVRKMLAERLNMSPRTVQIWFQNRRAKVKKDGKSTSSPNVSESSASTNGDSPSVKSLSETGLSRSVSATSNTTESAYKLISQEQDAFTPSLASDNSSSNISDWSADCDWAFQPMSYNAAGNSMYLPNSKESPANPNMTSDDAESDSTATTASSTQPWQLQIPLGSCDNENYLGIHHLKSTQEGDASTTTTTVTTSNTLSLTNGAPADWFADCTDSNYILGTSYFPIADYQNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSV6</accession>
    <name>A0A8H7PSV6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSV6"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="98" mass="10764" checksum="A7C364E1620A4EEF" modified="2022-01-19" version="1">MRNFGNNSLQVSTDNSNRSNSSASNDSFSVEGNTLNNTQSNTLNNHNNGRKRAHSGQTKAHPMTPDSNENAGKRKDVSGITRPDLQRSVPTFLSKLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSY5</accession>
    <name>A0A8H7PSY5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GB1/RHD3-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SEY1</name>
        <name evidence="12" type="ORF">INT43_003756</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">Enriched in the cortical ER. Concentrated in punctae along the ER tubules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSY5"/>
    <dbReference type="OrthoDB" id="1597724at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016320">
        <property type="term" value="P:endoplasmic reticulum membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000727">
        <property type="entry name" value="Protein SEY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03109">
        <property type="entry name" value="Sey1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008803">
        <property type="entry name" value="RHD3/Sey1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046758">
        <property type="entry name" value="Sey1/RHD3-like_3HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923:SF2">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05879">
        <property type="entry name" value="RHD3_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20428">
        <property type="entry name" value="Sey1_3HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="1"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="732"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="753"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="756"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="777"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="11">
        <location>
            <begin position="113"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="17"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="123"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2179969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="835" mass="94845" checksum="260960952729D94B" modified="2022-01-19" version="1">MQVDVQHFTMTEFKPLSDPTLSQEVHGSQLPNGLNNVLGNNDSGVLQSSSMTQEPAKSGDVQDFGSTSDAHHQDRWATDTGNTARLQVANANWIMHRDDLPEYMEKWGLLHAGFDYNCVAVFGSQSTGKSTLLNRLFGTTFDVMDETQRRQTTKGIWMSRGRGMDVLVMDVEGTDGRERGEDQDFERKSALFSMATSEVIILNLWEHQVGLYQGANMGLLKTVFEVNLQLFQSQRGKEKTLLFFVIRDHVGSTPLANLSNTLQADLEKIWAGLSKPEGLEDCKIQDYFDFMYTGLPHKVLMPEKFDTEVDQLRSRFMDPKDANYVFLPHYHKRIPADGFHVYASGIWEQIMSNKDLDLPTQQELLAQYRCDEIANAASEIFIDTVSVLKVPILDKGQLVQDLGPQMTEARSQALKSFDKEASRYHAGVYEKKRFDLLKKLNAQLSVYFVGQLRNLHKSAVIMFQDSIKSELKKPSYNFADVVDNATRNSEKHFKEGAQSIILPDTDWSYDSEFDQLQDDFAELSAQARSDEIKKMTKMLEKQVEGDLTEPTSIALNNPSSEMWHKILTVYKMAIANGQETLIKKAKSFNTSDEELDESVKNLVKQSWLLLRRKIDEELADSMVLLKLRSKFEDKFRYDDEGLPRVWKPEDDIDAHFKKAREETLALIPLFAKIDTTRDSDLEVESDEDFDFARSLTVLGESKQQDITTRFKRESDAFYLEAKRSIVATTAKIPTWLIVLLIVLGWNEFMAILTSPIYLITFVFLVTAGYVVYALNLWGPLERVLTAVAGEATKMLREKVAEGVDKARDQGIELNAMKSFAGPSKTTTTSTREKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTL3</accession>
    <name>A0A8H7PTL3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_001860</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TM2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTL3"/>
    <dbReference type="OrthoDB" id="408511at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050932">
        <property type="entry name" value="TM2D1-3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016">
        <property type="entry name" value="BETA-AMYLOID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016:SF1">
        <property type="entry name" value="TM2 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="10">
        <location>
            <begin position="84"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2179011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="160" mass="17348" checksum="9A16607B5A78CFE5" modified="2022-01-19" version="1">MPEYGAVPTQDPEQGQQQSTSQQASSCFVKLKDRILHPRHRKAAIAAWLVVLGIAVTLVISIHYSLLPINANPHDDVLATCRSDRSAFIALMLSIFLGPLGIDRLYLGYVFVGLIKFVTGGLFGILWVASLQLLISHLLPWATFLTLADAGSINGLLLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTR3</accession>
    <name>A0A8H7PTR3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_003835</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTR3"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF134">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2180048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="312" mass="35668" checksum="123A4D7551F0DFDC" modified="2022-01-19" version="1">MAAQQVLDKFSLETPFGVALWPYFDKVYTAATGKSANSFAFIEGVTPLSTQREVLIACVTYLIVIFGGQYVLRSASAFKFKLLFQIHNLLLTIVSLSLLVLLIEQLLPIIVKHGVLHAICSTEGWTQRLELLYYLNYLVKYWELADTVFLVVKKKKLEFLHYFHHSMTMVLCYTQLVGRTTVSWVPIVLNLTVHVAMYWYYFQTSRGLRIWWKKYLTTMQICQFLIDLVIIYACSYSYFTFTYAPYLPGGFGDCAGTEGAAAFGCALLTSYLFLFINFYRQTYKVKAKQPRNAALKASEIKSTQAKSKSVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTZ0</accession>
    <name>A0A8H7PTZ0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 9">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_003631</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 9"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTZ0"/>
    <dbReference type="OrthoDB" id="5831190at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1390.10:FF:000001">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000004">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2179845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="559" mass="62770" checksum="3415F647C22F6730" modified="2022-01-19" version="1">MVLANKLSTWQKLQQQYDSEGKSLVMKELFEKDPSRFQKFSRTFKGSKTDTSILLDFSKNRINEDIFKSLIALADEAKVAEMRDKMFSGEHINFTEDRAVLHIALRNLSNNPIKDEGNDVMPEVNAVLEQMKKTSEEIRNGTWKGYTGKAITDIVNIGIGGSDLGPVMVTEALKPYAKKGLNAHFVSNIDGTHLAEVLKVVNPETTLFIIASKTFTTQETITNAVSAKDWFLSSAKDQSHVAKHFVALSTNEKEVSAFGIDTKNMFRFWDWVGGRYSLWSAIGLSIAIYVGFDNFRELLLGAHEMDNHFKTAPLDQNLPVIMAVLGVWYNNFFGAQTQAILPYDQYMHRFSAYFQQGDMESNGKYVSRSGEQVSTSTGPIIWGEPGTNGQHAFYQLIHQGTKLIPCDFLAPVETQNPISGGKHHEILLSNFFAQTEALMVGKDEQTVRAELQKDKSIKSQEQFERIVPHKIFQGNRPTNSLFFQKLTPATLGSLIALYEHKIFTQGVIWDINSFDQWGVELGKQLAKAILPELTSSGEVNSHDASTNGLINFYKSHKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PU23</accession>
    <name>A0A8H7PU23_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">chitin deacetylase</fullName>
            <ecNumber evidence="20">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">INT43_002086</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="20"/>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PU23"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10952">
        <property type="entry name" value="CE4_MrCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000004">
        <property type="entry name" value="Related to Chitin deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF98">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="18" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 23" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034020596" description="chitin deacetylase" evidence="23">
        <location>
            <begin position="17"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="24">
        <location>
            <begin position="144"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAG2179236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="402" mass="43634" checksum="72123C513641CF71" modified="2022-01-19" version="1">MYGLIASAALIATASAVTTNYTSTVDPTKISIPSTPQTTSYDVTTECTYYQPPVPINLGDWPTNWKVATTNNMNQTAEFQALYNSIDWTKAPNVQPHTMGADGALSTTGYDVTNDPDCWWTASGCVTPKFPGVLKDISACAEPETWGLTYDDGPNCSHNAFYDFLQQQNLKASMFYIGSNVMNWPYGAQRGVKDGHHIAVHTWSHPMMTTLTNQDVLAELYYATKMIKYVTGLTPLYWRPPLGDVDDRVRWIASQLNLTAIIWNLDTDDWAAGVTVTVQQVQQNYQDFITMGTNGTFTNSGNIVLSHEINNMTMGFAETYIPQIKKAYKNILDVATCMNITHPYVESSVSFPAFSSSNGVSPGASGSSSSGGSSSSSGSAPSSTRSNAALVVAAVFACIAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVU8</accession>
    <name>A0A8H7PVU8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_008855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVU8"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF85">
        <property type="entry name" value="DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G15880)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2181272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="29723" checksum="4DCFC0FABC245AFB" modified="2022-01-19" version="1">MPAQKYFSTFISAILAAIFLKEKLGPIGIIGCVLSLIGAVIIVLHAPEDPDVQSVQELLSYMLQPGFIVYGVLVVVIAILMIWRAVPRWGRTKPFVYVSICSLVGSLSVMAIKAFGIAVRLTISGTNQFTHPSTYFFMVMCIICILVQLNYFNKALDTFSTNVVNPIYFVFFTTATLVASAIMYQGWNSAGVVNTVSLVCGFLIIFMGVYLLDSIARAGIAHKTEDLEKHDSAQTTTSSQDEYELSSQDDVHEKDQRFVIRHRSRAASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVW5</accession>
    <name>A0A8H7PVW5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA polymerase epsilon subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">DNA polymerase II subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008429</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates in DNA repair and in chromosomal DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVW5"/>
    <dbReference type="OrthoDB" id="10254730at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000799">
        <property type="entry name" value="DNA_pol_eps_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="7">
        <location>
            <begin position="312"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2180850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="553" mass="63378" checksum="09B1C145C9AE4F64" modified="2022-01-19" version="1">MAIPNQRKVSRAIYSIFTKKYGLHIQPDASRYLEELLRDDENINDAVERIVKMYQKRNEGISKVIVDKTTVQDVVEAMQAAAVAATNITPFSTQDELLKEDLSQMTLDDEPDNIDVSQYLHVVDAFSMPAMQYDYHRKGFVKSREKRSLLASADAKGDVYRDRFNLIRQRVLRNENFLPPSLQIIDNDSYLKITPIKSLIGHDNEQFLLLGMLTQIEEGKLFLEDNDAYVELDLSRCKSTIGLFTDNCFILVEGVYGDDHIFHVDELGLPPPESRAKTTSVFGHIDFLGLPPLNIEETVLLKEEQSNINISFVIISDLWLDQPKVFRAFRKLLEGYSESIVPLAFILMGNFVSQPLLFSGAESAKYKESFNLLADMIAEFPKLASHSYFIFVPGANDPWAGNTLPRPPIPDFFTSRLRQKVKRAIFTSNPSRIQYCTQEIVIFREDLLNRLRRNVLIQGDSTQDDRDLTKPLIRTIVDQAHLCPLPLAIRPIYCAYDHALRLYPMPDMLILADRCDNYSTTYEGCHCINPGSFPNSDFNWTTYYPAIRDSERW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PW04</accession>
    <name>A0A8H7PW04_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PSP proline-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008447</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PW04"/>
    <dbReference type="OrthoDB" id="8026949at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018554">
        <property type="entry name" value="FRQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052115">
        <property type="entry name" value="NEXT_complex_subunit_ZCCHC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13316:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13316">
        <property type="entry name" value="ZINC FINGER, CCHC DOMAIN CONTAINING 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09421">
        <property type="entry name" value="FRQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="7">
        <location>
            <begin position="557"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="641"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="705"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="648"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2180868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="759" mass="85752" checksum="4C56AA9AC4E65D7E" modified="2022-01-19" version="1">MRRHEKPLMADDDLDFSSFEDSNNSQYEGMDSATGPLIESSETTSESNGSSSPDNEIRNRKLPTRTSRKRTRNETMPECNDVIDDLLTRNKKLKKRLRRLEDLYLGHRPPASNELFEVRYFSMPQDKKRELESCLREFATHIRINNQSIKSKSGTSGSSSEGANDQSPNSANIYNNYNVPTMTVPLTDKKPTETQNMPAAWTLSRAQVCEVSNVVEETLTKPNIQQRDVIRSNSINGWLPLNCLYDASSELNDMNIPLSYLRHCLRRGSRHVELSKDQTRVRLKQVVMTGDSSHKDTGSDSTGSSFSGNNVFGSTFWALRPDMHSSHVDDHPQHRLSSVSNPVASAYDTSVDSSSFRPYTPCFSNRNVVSSVSSREEFEHAKRRTDSSNWSSDEAAANGMYNDTYNERHGKEKEQAQLQQPMQNSPKQQQTFHNPAEAAKVAPIIYIEGGTFCLDLSRFQRPHEAGPEEDDIPEYVRNSEAVLGQNWDDNFKWQDLFCWNCESKHHTLRDCSQKFNDTLLCKNALEFARRYPDHQCNFRRYFDETELRQRVEDMVVGKPSDELKEALGVGKDDLIMPYYDRMLKQGYPPGWKGVVRTDAHKQGKNIHKNPSDATGKLKVWDSGRLVQISAYDDQAVKSTPSADVAKAGGDDGPVKFRDGTTKPVVDGKIGSHYHAAIGAEQRAKHKHEPKIQLVDYPGLRWRDEEFKPTNESQTSRADSGIGSSNGGSEVSYKHAKKNKDVAKEDGLPMESDVQPMNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWE1</accession>
    <name>A0A8H7PWE1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWE1"/>
    <dbReference type="OrthoDB" id="9986409at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2181316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="410" mass="46922" checksum="FD69B5B8959AFA8F" modified="2022-01-19" version="1" fragment="single">KQQPRNTVFDSKTASPFIIYLGTSFAAVVLIYVAAIWNTQWKDIFNSYPVRGEMGLGRFIIKGVRINELGLKTPFAYPWRLASPTAAARISTWLGYIVHQLGQFFILANVQWLSRTGQIQAKWSSEYQWWNWQMLYLNASMVGYKFIQGHVWYQGLAGDVPEGTAMGAVVAILIGAMIIEIPYRGLFFGHCKSVAIPHFQDVIAFTKRYHGYVMSFGIVYNFHYHPVEATIGHLLGFFYQFLLLWQSTSFLHNSHRNKNWTMLLEVWVLIHGSVTAFTQPGYGWQIFLFGFSVLFLVNQIHGIPAIRNMPQSQRLSLLGGCYGAFLAVTYYGFRENQAYYRMTFIPVTEYLFCMFVLLVSSATASVVRKIRNLWIAALLTAVVYVLINTILVYCLALILGRGQVRVYNDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXZ3</accession>
    <name>A0A8H7PXZ3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PUA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_006901</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXZ3"/>
    <dbReference type="OrthoDB" id="409889at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21157">
        <property type="entry name" value="PUA_G5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000018">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF3">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="305"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2181975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="410" mass="44464" checksum="E516684E5178CA75" modified="2022-01-19" version="1">MLDQPSMVHKNYLNQARPSTDSLTIVIKIGTSSICDEKTHFPLLSNLSMIVETILQLKARGHRVVLVSSAAVGTGLRRLNIDVKPKKLAAIQAIAAVGQGRLMSLYDDLFGQFNQPIAQILLTKNDLADRSQYLNAVNCFEELLDMGVVPIVNENDTISSAVRVENEIRFGDNDSLSAIAAGMVKADYLFLMTDVDCLYTDNPRTNPLAEPVWKCDDIQALREKIVVTAPGTSLGTGGMVTKLIAAELATAAGVTTIIARGSTPQNILKIITDESDLPLHTRFTAQDNPLIDRKWWILHGLKSAGAIFVDKGAYHAIVAKQRSSLLAAGIVKVEGEFAAQQSALVVHETTDESGQTKIVEIGKGLVNYSSIEIALVKGRKSSEIADILGYVDSDCIMNRDNLVIIAPRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PY16</accession>
    <name>A0A8H7PY16_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PY16"/>
    <dbReference type="OrthoDB" id="2353340at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034004289" evidence="1">
        <location>
            <begin position="20"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2181903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="205" mass="21786" checksum="CF68DC3B669029B7" modified="2022-01-19" version="1">MKLSILSVLLAISATSVSAAPATSFSGTIYVYVNSVPHPKTTFLKKGSNNHLVTDGIACKGKKTLPGKGDALKGTFTTVNNQWDFNGKHDNEIRMGYVKIDGNKCLSLTKGNALSFEDCPSFSQEIKKGNKFAWFHDIRSSAIWAYGGDANAVETNGLTLQAGNLQTNGKTLTGIALHDNSLQNVFIGLGYVGLGDVSIPPTGCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYH4</accession>
    <name>A0A8H7PYH4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYH4"/>
    <dbReference type="OrthoDB" id="2398262at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2182568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="304" mass="33689" checksum="3D21EC987F4A024E" modified="2022-01-19" version="1">MVIWNIFATSILIAALVNPNSMYTAGCEIQKTLYELADQVRIKQRSIISAFLHAVLITGRFLVLVTLILGNFIVIEFLGHEDKTARTTGEAINSAQKLSEPLPTSDLNAVVDSVKEKIDSPLIGNTSGDADVMRTQPETTSHNDFADTKVETIISEESKDYDFVNKSEDAGDSTTTVSESVPDHHEEKGNSDAHFVDAHDTTVPTATPGELTLELLQKKHNDQDSHGQQTDPDQNVLPEIDSRQRHNNNQIKRQSLLLPELVPQAPAASQSTELPRRQFSIMHKKTKSTEAKPKKLLSIFKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q000</accession>
    <name>A0A8H7Q000_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q000"/>
    <dbReference type="OrthoDB" id="2153288at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2183422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="601" mass="69640" checksum="D385738866E69E9F" modified="2022-01-19" version="1">MFTVGLAMVYLASLLQDPPFERPKALHIADRAFFERKPDDIVLSVAGPYLYMSAVWREGEYPEKYGHKRGTGREAIGVRGRIKQFRAPLELFRSNSRVVEEEAHWEELFVHDVNGKIAHISKHPDQLSPPNVPGKSYFSVLYQEIDGEHMKHVARVYYLGKSSNKSSIIPGIGYTETIEYRAFDYKDLVLPGTTWISAFSLEDGMLLYTRDPDRYYFRTVPLPADMYRIKVSDEDKRLVVDASTEGYVMRGRTQPKAFTGYDDMVARLYSPVNDTLRLATLRVFKFTDYSELTLTVMDNLTELDTSQQLEPGNNWRTRGFYDPWTDKREEDDYSPINENHYYQPERIFEMPKLATARSASLKTFLFPYRNAIFSMDYVDDEEQLRELGSYETIIEEWFPSTKGDRIGGAYMFFDRETIIVPYVDGNYEQEFHGVILNEDGNICVAWTNKNYIFIYKRGEAYPDRLSLQTVEGEDTDMNDLTEEEAKRHTSKLQRLNLIRKASDLMWSPPWAITSFPGHSRNVGIVAAEVWNSTRSFDRSPSNILLLAMKDGRVHSYALEHSEEQTPTGIWSFVTKRWDMLTVMLGAIVIFVINEIRNHPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q075</accession>
    <name>A0A8H7Q075_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_006504</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q075"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF86">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="62"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2183498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="520" mass="59082" checksum="F8A60D1519C0CAA2" modified="2022-01-19" version="1">MSQDLKEKIEIHHTSDKVLEIEDTTLTSLDGHSLSNDSAYVQDLQWTDEEEKKIVAKLDRRLMSYVLLMTFVLNMDRTNISNAISDNLPADLGFTIDGINTATLIYAIVFTLFTIPTNVIVKRVGAHFWIPFIMSAWGIVTWSHIFIKDFTGYLIVRLFIAATEAGFIPACLTYLTGFYKTNELATRLAWYWGIQSFASAFSGLLSFAIFRLAGVAGLEGWKWLFLIDGILTNIVGAISFFYLPASLTKTDRLMFGKKSWFNERETQIAVTRIIRDDLTKNDQYKHVTWEDFRISVLDTKLWVHLIIAFLTLMPITPIGTYLPTIIKQTGFSVYIANLLAAPTYIVGLFFSILIARGADKYGNTSLWAQAAIVWGLIGALLLEFLPDNTNKWVMYFAAFVIASTPSSHGMHIAWMSSNLAPIGKRTLALGWVIGAANICAVPGSQIYTASDSPRFHRGNWILIGITLANGFFFLLQRYRYMLTNKYRQKKWDSMTEDEQRVYNETTKHKGSNRLDYRFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0M6</accession>
    <name>A0A8H7Q0M6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_006145</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0M6"/>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="371"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="14">
        <location>
            <begin position="8"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2183150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="456" mass="50709" checksum="D06BF519C799F453" modified="2022-01-19" version="1">MSNLLSVLSLNCWGLFAVSKEREFRLHAIADYIASTRHDVVALQELWVWEDFEYLKTVAIHNYPHMRYFYSGALGSGLAILSRHPIIEHSYFRYALAGRPLKVFHGDFYVGKGSGSICINHPEAGLIDIYTTHLHAGYGRRKEYEGHRITEAWELCKLMRASAAAGRHVIAMGDFNALPTSFPYRLLIEHGAMTDSWKQVSGFDMNQTPIDDNLTAEAAINVLGVTCDSPTNSWSKHFLKQSANKKKYGDRLDYIFYRPNPQMECVKSNVVLTENIPGTEMSYSDHFGVCSVFNVARKDAKSLQDDACYSNLSQDVIDGIVATLQSDQVASKKTANFLLRSLAAMLFAIIALIVIIVALPTAFRLHDRGDIVTVIVTLFGGLLLAACALVAPVALIVGFVFGHTEQRALLQFLEEIDTLKSVIKSAALDGDLIQMHDEELSTPGRRRSTNGNTLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0M9</accession>
    <name>A0A8H7Q0M9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_006634</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0M9"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041672">
        <property type="entry name" value="Bap31/Bap29_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18035">
        <property type="entry name" value="Bap31_Bap29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="13">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31/Bap29 cytoplasmic coiled-coil" evidence="14">
        <location>
            <begin position="150"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="168"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="169"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2183626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="203" mass="23268" checksum="2BE14583BC9AF824" modified="2022-01-19" version="1">MVTEIAIFGVLILPLPSHWRRQLVKFVSNSPMVGRAIHILKIVFVPRTWHRRLANITWPLVDAVNRLQRPGGIDDQSASSNYMMHDVRTESTFAARKFYAQRNLYLTGFTLFLSLILNRTHQLLVELSAAEEALSQATGQPLNDEESNSLRSQIAELKKKHLDYSTLKKQADQQSKEYNRLADEHNALEESSRDGVKETRKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0V9</accession>
    <name>A0A8H7Q0V9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">COPI associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_006333</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0V9"/>
    <dbReference type="OrthoDB" id="423534at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013714">
        <property type="entry name" value="Golgi_TVP15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08507">
        <property type="entry name" value="COPI_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2183328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="26999" checksum="D3CA3D8A6A5BC5EE" modified="2022-01-19" version="1">MLSRTKIENVTCLSLNFINIAFYLLVIAAASYKCVDSNFSQIVLCIYGDIIAAALVINEIRSPILTQEYFRFLCIYRGRGLVFFFFGCLVLAKDVLNIIVGTLTLCLGLFYVILSFISSIPPPNSLVINWQNWKDFSAEGLDILRPRNSTLESAAAIHLKGPPRPTSSIIPPTLSRTPVGYTLQEADIGDWRVDSDYGSVKESARYISQPSSEYDGSFATPVQSPRSSELSSPNVNYPGPHRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q160</accession>
    <name>A0A8H7Q160_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q160"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052408">
        <property type="entry name" value="Exonuclease_MUT-7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765">
        <property type="entry name" value="3'-5' EXONUCLEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765:SF2">
        <property type="entry name" value="EXONUCLEASE MUT-7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="2">
        <location>
            <begin position="667"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2183420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="888" mass="99093" checksum="EA192D251D38B5F4" modified="2022-01-19" version="1">MNTEAEPVEEEWVINNVNSSFKKPPKLSNAATRLVRAALPGRQQPASFGPAFNTAGPINVMANAPNESIATGSQEDNMQFPATLTPTDNRNSIKPVDSTPNRRRPRQRRYNDAKYNQAQGESEYTDGSCSPFSSKQALSSGPEQLGSYSVEDAVATPSPIGRNSVRSDSFGSASERTQGATQKPAVARPSPEKVSEKIKNGFVDGLPRQVVLCLLTALSEDKAKLSKAEKSAAYENCWQALRTGLSDCSDPVGFIIESILFLTGSDDKPNDPGHLKLERTIRTVVRILCESLESYIASLSKTKGVKLAARNDPTLLELVLKSSASKEEDLIDLNEITNDNIQAEDPEIITMADLQPFPFGNWKEKIIGLDDQRHLLDNLAISQHPVIVYLCMKPFRLSELLAAGQAEETLGIQLVESLMESNCMLEAIMCATTLKTVDKLDFEDVVTRIVLSGDTACIIRFAAVDEEMPRKLLNFFNSQLRFAYDGKFKIIPVERLEISSNLDNSPMRKLNERKVQKDLANFALRIMDSYGIDPKEYYFVFLTNSYVSLRWLISQRACQQVEENDYSIEATSNYNGLIYVLCHDVALKRLAVKEFIDMQDPYAAPYFAESFDQMAFYNEYISTPMSQRLISAIAGEQNSRSRVYLPRRKKKPATGKEHYKLPENVQLVIIDNSSGLTAMRSLLKRSQLCGLDTEWIPHLAKHAFMRTSLMQIASELGVVFLLDLVKLCGYNDGRVGFDGVTGAEPEDNIQQETFSFLKDLFTDQRITKLAYDFRGDIDMLSKTFPGISDVTLESFVDLANVNSCIPDQSETTFPLAGGGLTGVVETFLNRSLNKKQQISNWEQRPLSFEQAVYAAGDAYSLIEVFYTLYNMNHPILWDDKLGNGPSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q197</accession>
    <name>A0A8H7Q197_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q197"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="101" mass="10137" checksum="E39FFF0B979A18CD" modified="2022-01-19" version="1">MPPELPPPPGQPVLPPQYNFYFYSGGPAGMPGLGPPPPPPGEGSGGEGGGSKPGSEGGGEGEGEEEGPPPPPIYVQGNRSFSSPRQVAADGEPVKENCTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1W9</accession>
    <name>A0A8H7Q1W9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_000321</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1W9"/>
    <dbReference type="OrthoDB" id="10266426at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015215">
        <property type="term" value="F:nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000075">
        <property type="entry name" value="Nicotinamide adenine dinucleotide transporter 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="15"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="115"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="211"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2184412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="306" mass="34094" checksum="30E8FDFF4BEE1B8B" modified="2022-01-19" version="1">MGVSANWWKSIAENHENIKHSIAGAGAGIVSSIVTCPLDVVKTRLQNQGKGHPGIALYRGTYGTLSRIWTEEGIRGLYRGLGPTIFGYLPTWAIYFTVYDYCKVRMGGRIGKPDDHWLVHILSAMTAGATSTSMTNPLWVIKTRFMTQNERTAYRYNNTLHAFKTIAKEEGLGGFYKGLGPSLLGVSHVAVQFPLYEKLKIWFNPDRGTPSGTITILMASSLSKMAASMATYPHEVIRTRLQNQTVKPHKYHGIMHAIKIMMKEEGPLAFYRGMPTNLLRTVPASAMTILTYELLVSKFDEIKHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2B8</accession>
    <name>A0A8H7Q2B8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_006412</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2B8"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034730623" description="Thioredoxin domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="19"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2183406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="442" mass="49220" checksum="3BCE123C258AF879" modified="2022-01-19" version="1">MLTNILIATFLLAFQQQNVVAAATQSDISNYQPNTAGEVVVLGGANFTQEVQDHPERSWFIKFYAPWCGHCKTLAPIWVELANTLKGKTNIAEVDCTLAEDICRDYGVTGFPTLKYISKNSAVEFRGARDHSTLLEFTEKASKSPVTYVDNSELTAKLPEQEVSLIYIYNKDQPETANHDTIESVGHALLNDAVTYVTSDLEAVNNLGLQGKSLPMLVLHKNGRTLVYPGQGFLNTKEDRKDILNWIEDRKYPLYFEMGPGNSNEVLRGKKFVVLSFFNPSRELEKQTDLLKATAEAYIESQKEDNGQVLFVWLDGIKHSRYIYSVYGFGGNDLPAVVITDAKNHNYFAENTDGKPLNLANPQAMVQAIADAQAGLLSTKSTIPRAQKTAIFINKAINKARKYWYVSIPAFVAITYVALKPLFAFIASMDGTDSTNKVDKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2C6</accession>
    <name>A0A8H7Q2C6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chalcone isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2C6"/>
    <dbReference type="OrthoDB" id="18193at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016087">
        <property type="entry name" value="Chalcone_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016088">
        <property type="entry name" value="Chalcone_isomerase_3-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036298">
        <property type="entry name" value="Chalcone_isomerase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284:SF3">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16035">
        <property type="entry name" value="Chalcone_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54626">
        <property type="entry name" value="Chalcone isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chalcone isomerase" evidence="1">
        <location>
            <begin position="100"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="275" mass="30525" checksum="53B2460FE192CC14" modified="2022-01-19" version="1">MFRVRSVSQAARRIGQSYPVAQPLIPGHRLVARRLASTASAKTTTSSTAWMAPAAVAAVGFSFLLSSAVQTEAARSETIEEPMTNMQFPLTIHNGTDQKVILGLGSRQVSFLKMNVYVMGMYISVKDARVLRKAGIWTDAQAAMDSMDHAQQMLKQPIDIAIRIVPTRATGGQHLRDGFTRSLLQLMRDHSKELTEDDERQILEGIQDFKAKFPSTKVNKGDEFIFTRTANGGLKIEFRGKELGTVKNRWVADNFVVGYVKLGIVKNVLENDNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2K0</accession>
    <name>A0A8H7Q2K0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2K0"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="210" mass="23517" checksum="EDEF5F57385FB9FB" modified="2022-01-19" version="1">MGVRPDLLALIPNYALHNKNEPAQYFHANYSVNANRTQSRRSVQSPDWIVQHQQQLDADQLSSANSSPLLDAGTATVIAKKASKMLTVDNLRKVIQLPSGESEQDWITINRKNLPRSHDEMKIIHYNSALTVLEFFQQIMALYATISDSCTPSSCPSMTAGANYEFFWAQEGKKPIKVSAPHYVDLLRTWVTSSLQDGQLVPQQLDRSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2L0</accession>
    <name>A0A8H7Q2L0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2L0"/>
    <dbReference type="OrthoDB" id="2279327at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="285" mass="32213" checksum="B8179F8BFEDBDDF6" modified="2022-01-19" version="1">MATSDASIWTSGIASLAPEDILRLLKISDTYVKSSVVTRTDEEADTAIYALGVSNLYELHKAISANVLVIHINPDCSSLIQEQRRRLRDIRMRRNIEWITILGVFSSVFITHWVKHQRLLGDQRHGQSSLIQDLKALFSSSPSPATQNGPYGNIDTRLPASMIMSMEGFRKDPLVTEGRAHNNRRYGFCWVSVLSPLWKDRSNLLLTSTLIASIAFQKRSRHDYELIKIFPTDQGSAHPEYFLIRQDALHVKQTVVQQTLERIPLLVAAVTSTILIRRCFKALSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3H0</accession>
    <name>A0A8H7Q3H0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_000533</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3H0"/>
    <dbReference type="OrthoDB" id="10254187at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000022">
        <property type="entry name" value="NADH dehydrogenase flavoprotein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1590:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="ADTRP_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371:SF3">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01257">
        <property type="entry name" value="2Fe-2S_thioredx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2184620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="558" mass="62955" checksum="75CC9F95A59EE9A2" modified="2022-01-19" version="1" fragment="single">FYFFLVMSKVARIALHLLGCASNLWGLSKVEAVPNPYADGFGGHYQYLTILGLTVATLSFSLCLIRDFVPGFLNRKLYVNSMYITYIRWVVNCSLLLLLTNIPCTTQLEGLISVLYWGMTLIDPHLLVPKDVPPIPMLIDFSLHLFPAVFLWVDFLLFNVEFERAKSHVVNIYLFAIAYYVWTWYCFSKNQYYAYPFLAELSDTGRALFYAGCGTMCWIMYEAGNNRIALQERIYTDQFTVVGKLAVKRKLPKFSATSSLEKTDGSSRLGRFLFTTDKEKVFEKTGRARTSLTSFATPSPHSEFISMFSVRAVVRQAATVSTTARNLAAKRSIHSSPAALSDHLFVHRNTAENNPSIPFAFNDANKKRIEEIMKRYPPQYKKAAIMPLLDLGQRQNGFTSISVMNEVARLVDVPPMRVYEVATFYTMFNREPVGKYFLQLCTTTPCQLGGCGSTKILETIKDHLKLEVGETSKDGKFTLVEVECAGACVNAPVLAINDDYYEDLTPETTKKLLDNLQNDKPITPGPQGGRHTCEYAPGKYTTLNSEPYGPGFRMRDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q410</accession>
    <name>A0A8H7Q410_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q410"/>
    <dbReference type="OrthoDB" id="2305845at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052043">
        <property type="entry name" value="PolySaccharide_Degr_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886:SF8">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="369" mass="42296" checksum="A891E86F32C1F707" modified="2022-01-19" version="1">MSTSQKPATEIHRLIKSLIHNLVDIQDTTGKFLLHLDNGIIVDTKAWNDWEWTQGVGLYGLWKYYSMTDDKQVLDIITKWFRDRFAEPPRHKNINTMAVFLTLACVYEETGDKTYLPYLDTWAEWAMNELPRTEYGGMQHITFAAENYQQLWDDTLMMTVLPLAKIGKLLNRPHYVEEAKRQFLLHIKYLFDTKTGLFFHGWTFEDGGHNFANAFWGRGNSWVTIVIPEFIELLDLPPNDPIRIHLIDTLVAQAQGLSKHQNESGLWHTVIDDHQDDSYLEASATAGFAYGIMKAARKGYISNSYADVAKKAVDAVISNIDETGELQQVSFGTPMGDSKQFYKDIPLTSMPYGQAMGMMCLVELLWSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q437</accession>
    <name>A0A8H7Q437_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WWE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q437"/>
    <dbReference type="OrthoDB" id="2418439at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2186134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23769" checksum="DBEE3AFC6DB3F607" modified="2022-01-19" version="1">MTQSSSSGPSQSSMALYSSPYRTSRPRLESPQRAPFPYNRSSHYHRYTSPSPPQLPSNNRGNALPFSSSTNTTPNSAPSIKSTNGSSNTMMQQQHQPAAVIASIAEAKDKQQAAMAVQPAQQPTSTTAATNSDSQQDSAQSQEITWLFFRDNKWMPFQSENHYKIEQAFTLGGIYVDIKDHNFPQLKSIRVFPTRFYLSYLGMKYRLSCVIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q483</accession>
    <name>A0A8H7Q483_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase M3A/M3B catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_000672</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q483"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000006">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="9">
        <location>
            <begin position="222"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2184759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="687" mass="78581" checksum="D0C761C1A1A386DF" modified="2022-01-19" version="1">MTTTSAPQPTLNFGISASELTKTLKDIIAQEQEVNDKVAGLSPEQQTFESVILPMARINNEVAGLGHLTTSLSYFSPEKDVRDASVEAEKEYDAFGIEQGMRLDLYNAVKNVFDKTDLQTLDPEDARLLTKTELDFRRNGLALEEKERNELKEIRKRLSELSIEFSKNQNEESSTAATITLVVLQDELENMDDDFLSGLKTEEVDGVQKYVLTMRYPDVLPVLKMCKNENTRRVHYIAYESRNKENIALLEEAVKLRRQAAKLLGYPSHAAFILENKMAKSVEAVRTFLDDLVTRLTSIGETELDRLKDIKRKEKENRGEEFDGKINGWDTAYYLRVLLEDEYQVDQQVIKQYFPLDNTVNKMLEIYSKVLGIRFVKVPADKAVVWHPDVQLYECWDDTDTLEFSGYMYLDLHPRENKYSHAACFPLQPSYLKENGERVAPSAGMVANFTKPTADKPSLLKHDEVVTLFHELGHVMHHICSRTKHTRFNGTSVERDFVEAPSQMLENWCFDKESLKYLSSHYETGKPIPDDIIDRIVKAKNVNAAMFNLRQLFFGVYDMDIHTSDDENLDTTAVWHSLRKKVSLIDSPEGTYGQAAFGHIMGGYDAGYYGYYIDKTCVNFAVWSKVFSSDMFFTKFENNTLSRENGLAYRHKILSRGGSRDGMDLLRDFLGREPSSDAFMKEVIGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4H1</accession>
    <name>A0A8H7Q4H1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RNA polymerase II-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_000425</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RPAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="348201at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057989">
        <property type="entry name" value="TPR_RPAP1/MINIYO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25766">
        <property type="entry name" value="TPR_RPAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="7">
        <location>
            <begin position="204"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 C-terminal" evidence="6">
        <location>
            <begin position="323"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1/MINIYO-like TPR repeats" evidence="8">
        <location>
            <begin position="1199"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2184516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1341" mass="150549" checksum="CC79091D639BAC58" modified="2022-01-19" version="1">MNNSIRPKLEDAENEEDLLQMQEEFLSMSSTPAAKVVRKPPPSFGTSSAQKTNVEVAPVLDQYDNDMPELEDVPVSETIPAKTEPKPKKKSLFAARRAQASNATVEQSPEDDTPVTKRMIDINSMLGNVIGTVKETVPKTDKDVVKLDFDLGLTNRPRQASGFPQPVHRSEFRKRLDRKQKQEEVASKADTPAIKEEYVNEKYKDIHDENLNTLNSMSEEDIAAARAQLLASMDPELVKKLMTRKPMSERKGDEDVDAQPSKKVQFADINAEGDSLEEDHPLVMKKKYFENVESEPEKLAWMGIGDQRDTNSDIPSFTSEAAQLRFDFAGNIITDENVSVYKGLHHHGQNPNQAGYTLPELFHLMRSQVSSQRVIVLNTASRIIAKSKQLEYGSTVSESIWRFIIHDMKGIIYLRAALDDKYTVAVAAAISAIDALLCDNGFSSSIYGHLHTSLDRGYETIWQSPTSNEQSSLSNQTLDKKFTNTIDAINSMKEDEEPEEPKPDSVDAHAKLSQSDIVSALVQMKILPRLRYLLEHMCQPGGFDDGTVLRLIATAHRLAQNSDSVCEAIAVEEPKIVDLIVQHGIEQTQWPIVSISESASKTKKSSTRWPSLQAIQFLRTMAASKKQIAISVCVETGHVDNTLRFLTISPSVMSDAAATEHAFELQLATLELYRLLAGYGLYCHVMADLAPKIPLWIRSQDDLNASTWNTESQHVCLRAIATTSLLEVYLHNAQDTHKTLPEHDICWAQPTAFHDLVLSTFVKCASHFGELGSKQTLEVPDYMRLCLLSASMGYLATWCRYLDSNPPAEKIIVEDTWNAITNVLTQSSWFSTHSQIFARINASRGHYQPLQYPNLSGVYTPDMTEYLTWLCKRDIVADIAARLCQLMESYGRIPLSDIANKAYEYLVQDSLFDISINDIAKNYLNSDTRDSTTLSEKRRSRKQPALAVWSHLHAIGILTNLTQATRVPSKCTIERLTILCTYFMNNLCSGDEWPAHWIFSQILPNIVSNNNLTETTLEPFYKQAVGSDDKIAESKGLYLHDGRGIETLTLDYSNSPNSSAIPRNLLAWLLLPIDELYHADKSEILRELPHGYNATEPNIIVATLDKALQFYGISPHLDLTPVAITLMKIYLIGERSGRNVELETGWARADSDSEELFRDHNVTLKIKAWLDCISSVQLHVTLQQAWSDSSHYVQQAQVPFYQFYQDFAAQYAAVSFGDQSFARLLLLPALASSPIDYKHLLWSDMIDILPTIRITIDDLLGGHNVYLEPAETSDTILRDMLIAVCTRKVHKEDVNGGEKCALYWLALHHLRAAYLSEATDVSLKRDLSVLSTAFDQPTPWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4W0</accession>
    <name>A0A8H7Q4W0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_001002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4W0"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2185089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="73" mass="8406" checksum="776A203D71788F0C" modified="2022-01-19" version="1">MKRLQDPVQEEILIRTATPEVQDLIKKVEIVGDDVKLRFQMKALKPDEALDISKISQKTENLRRAINPTSKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q550</accession>
    <name>A0A8H7Q550_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002434</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q550"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2185996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="285" mass="31095" checksum="BD944C0AD90CC47E" modified="2022-01-19" version="1">MDTNVRTQTWSTDAEESLTDMSSYSMDPSNGKAEVPSLNIFEPLNSLDFGYLEPCYVTNSTTNLTESSLGLLSANYASTAQKPNPSYSGIPSPISSNSSTPMMEPLTGCNGYFSSLDNMSMPISLPSPRVSHDGFADISDASSDTSEFIQQPCNMLTSSKNAEKVNSKVINTPRKELGASDVRVHSCSLCTEKFTQASKLRLHVQKSHRPHQCSACPRAFARKHDLHRHFRTHTGVKPYECAGCKATFARTDARQRHWRMDLQCAAKGRLALALLGQSGSASPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q599</accession>
    <name>A0A8H7Q599_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome biogenesis protein SLX9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_002576</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLX9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q599"/>
    <dbReference type="OrthoDB" id="18703at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028160">
        <property type="entry name" value="Slx9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31109">
        <property type="entry name" value="PROTEIN FAM207A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31109:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN SLX9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15341">
        <property type="entry name" value="SLX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2186138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="182" mass="20939" checksum="308548BC987A70A0" modified="2022-01-19" version="1">MPKVTRTRTRLHKEAKPSVNDRKFAVKQKEVLERIETTHDEPKLLKTEAGEEEEEGLVSKRLKRKLRHDAWMQKLDQTYNKLDKQKKKKNKNSLAVDLKDFGSILSQIHSTNQPGEPFVRGTASAPAPINPLLNAKPKPTSKKARKAAEMQEILRFQNVLQHSAFKSNPIETIKQHVKNTYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5N8</accession>
    <name>A0A8H7Q5N8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_002212</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5N8"/>
    <dbReference type="OrthoDB" id="1681166at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16456">
        <property type="entry name" value="RING-H2_APC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024991">
        <property type="entry name" value="RING-H2_APC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12861">
        <property type="entry name" value="zf-ANAPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="35"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2185775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="87" mass="9799" checksum="AD6898E62040FE7D" modified="2022-01-19" version="1">MKVKVNAWTVPAFWSWDVENEDVCGICQVAYDACCPTCTVPGDGCPLIWGECSHVFHMHCLIKWLNAPNSQEQCPMDRTPWRTAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q613</accession>
    <name>A0A8H7Q613_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q613"/>
    <dbReference type="OrthoDB" id="2390177at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2185923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="129" mass="14746" checksum="D3728D456CCEC233" modified="2022-01-19" version="1">MVFGKASSTSSWYQLDNILDSLLPRFYEAESRRVDNGSSGRMVHEHDHEIDDIREDMYESALADSEFAQWLNEPVPAAHSVPQDTALERLRMLVKHFGSSFVSRPLTTQYPSRDKGKGPSDAEHWRNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6B1</accession>
    <name>A0A8H7Q6B1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6B1"/>
    <dbReference type="OrthoDB" id="2343100at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034381725" evidence="1">
        <location>
            <begin position="20"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2185869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="111" mass="11747" checksum="14BB92A14B0560F2" modified="2022-01-19" version="1">MKFSTVSLLLLGLTTSISATSYEIYIQNKAGDSLYLDGTGRKCQCLSNTQTDHIANSYGGIVRVFASTDCTGAYDTIKSQASIYNAEWVNSVSFGSSGSSSGPYGCPNLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q7U1</accession>
    <name>A0A8H7Q7U1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_002784</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the creA/MIG C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q7U1"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000089">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000152">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF1">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="66"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2186346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="196" mass="22283" checksum="12EA94EE6BC27197" modified="2022-01-19" version="1">MPSSTDNNAPRPYQCPLCQKAFYRLEHQTRHLRTHTGEKPHHCTFPGCGKRFSRSDELTRHTRIHTNIRSSGKRQRCTKPSNSNRSLRTMQHTVARQTISLPPSPSLSDKAQSDNESDLQTPKASPTLAALKLAPLENVVDMSYYYRYHDTHRVLPPLNAVLPLSAFGSRDTTMLPQPHYSQTTEVTLPSIQSLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7A9</accession>
    <name>A0A8H7U7A9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_005111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7A9"/>
    <dbReference type="OrthoDB" id="2324583at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2173691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="127" mass="14885" checksum="B7E3175C6C6E35C1" modified="2022-01-19" version="1">MLFIRLSSHLTSIPFFFMEYTFISNYSPHPATDDMLGPLDGPRKPKDIDESHQWLFFRNSHWTPFDAHNQAKLFETLLMNGTFVDIKDSHFPGVERLRVFPASNYVSYLGTRYKLSHILLPRLTYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7Z9</accession>
    <name>A0A8H7U7Z9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_002929</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7Z9"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF35">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="10"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2171307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="516" mass="56251" checksum="0CEEEF1940F7AA19" modified="2022-01-19" version="1">MFKVTNVYVIGMFATVGGLLFGCDISSMSGLVSNPVYIGYFNVDSSALSGAVVAVMSAGSFVGAIIAGFLSDHLGRKETILISACCWVVGSILMCAAQNVGMLIVGRIINGLAVGGASMVVPVYQAEIAPRNIRGRIVSFQQWAITWGILIQYLVQYGCSYIPGGNTWPGGNTAVFRIPWGVQMVWGIGLAIFILGFPQSPRWLADKDRWDETLEVLADLHGKGDVNNEEVQYEYREIQAAVKFDREQGANSYIECFKQGYAGRTFLGMCIQMWSQLTGMNVMMYYITFVFQGAGLSGNTANLTASLVQYILNVLATIPAILYLDRWGRRPTLIYGAFAMCIFLFIVGAIMGARGHAVSDPTNPAVNWALAEGDTSGSIALIVMIYLFVCSFATSWGPCSWTYPSEIFPLRIRSKAVALATATNWAFNTGLAEWAPPMMQSINYKAYFFYAIMNLAAGIHVFLACPETKGRTLEEVDALFNSGVPAWKSKHVDSHELAAKLEGDDANIEKKEVESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U945</accession>
    <name>A0A8H7U945_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_007525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U945"/>
    <dbReference type="OrthoDB" id="2307419at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="466"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2176871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="556" mass="60462" checksum="0902B71E90A58663" modified="2022-01-19" version="1" fragment="single">PTFEIWALDLSQSFSAETAPWQLKVNGSAYSSLLLPYTDGVAYASSAGNIIAEAGQGGTNQLAAGLVSYNPVNENVGVVPALGDHGSVRMSMTANVDSNNNAWYYGGRTTNSAGQPQYHRFKFNDLKAYEIDEQYWAPQFLVGPQNFQPGYRAGHTANLIDQKLFVLGGVGALMNATTNQFVEYLPDFTTALVFNLTLSDTRVANYTTSSPSGSFPEPRLKNSMVEAPDGHSIVMFGGFSTSNASVIFDDVWVLDSCYLRWEKKTIAGVAPAGRAGHSAVRVGNYMIIVGGTYVFCLDCSYSTLRIDISLGSALIGFTQINADYKFDLYANDLAILDMSQWQWVNSFTTSTAQNTQPTPLCTFPFTLPDGQTGDSPITPQAPVIVGGSNSDEAKKLGFGISFSTVAFLAILGGAAYFVFKRRRRSKTTTPYWLPGMGNDPSNTGHDLGIYPPADHSRTTDYPMFVYDPEGDKKKNGKIALPAEDSNTRTYSASDVEDWRAKEEERRPSDGKALPQHSSLWNKVRGLGGNSSGHDDEAGLIKGADKSGWQRLEDFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9T0</accession>
    <name>A0A8H7U9T0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 1A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 4C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_006027</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 9">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eIF-1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9T0"/>
    <dbReference type="OrthoDB" id="274995at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000071">
        <property type="entry name" value="Eukaryotic translation initiation factor 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="11">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2174965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="137" mass="15855" checksum="C16D5F7BDD3D154F" modified="2022-01-19" version="1">MPKNKGKGGKNRRRGKNENENDKRELVFKEEGQEYAQVVKMLGNGRLEAQCFDGTKRLAHIRGKMRKKVWINQGDIILLSLREYQDEKADVIQKYSADEARNLKTYGELPDTAKINETDTFGPEEDDIDFDFDIDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UB00</accession>
    <name>A0A8H7UB00_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UB00"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051604">
        <property type="entry name" value="Ergot_Alk_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162:SF1">
        <property type="entry name" value="PRESTALK A DIFFERENTIATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2174922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="289" mass="32235" checksum="8F560848744012F3" modified="2022-01-19" version="1">MSERVFVTGATGNIGKKVVEELAKNNVQTTVYARDVEKASKLFPNGSNLTFVQGDYDTIDAFSKAIVGHTRLFLLVTDLPRMTDIKVKFATIAYEAGVKQIVDISTNMVALAWRYNFASAAQGPAEEALINIPKRGAYVALRPTAFMSNHVVYDKSTIQQGFLQGVVAPDYKQEWISTNDIALASANILQDSVEKHGDAVYEMIGDSVSPSERAAIFSKALGREITYNQVRPLERYKILTEYVKVPHYIAYAICSRDPQKDVTIEIEILLGREPETLEQWLNGNTDRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBS4</accession>
    <name>A0A8H7UBS4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_007766</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPPC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBS4"/>
    <dbReference type="OrthoDB" id="10250284at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010378">
        <property type="entry name" value="TRAPPC13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055428">
        <property type="entry name" value="TRAPPC13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055429">
        <property type="entry name" value="TRAPPC13_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055427">
        <property type="entry name" value="TRAPPC13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23643">
        <property type="entry name" value="TRAPPC13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23647">
        <property type="entry name" value="TRAPPC13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06159">
        <property type="entry name" value="TRAPPC13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 N-terminal" evidence="3">
        <location>
            <begin position="35"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 middle" evidence="5">
        <location>
            <begin position="206"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 C-terminal" evidence="4">
        <location>
            <begin position="355"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2177110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="50414" checksum="8996BF74B0E33A04" modified="2022-01-19" version="1">MASINTVRPNQAAKPAPSSPHPSTPSQQDENQSPHSLALKVMRLSRPSLANNKQPTYQDADAASLSNSLTPPDEKKKRDDTKEGSASDMQSFGLDEVLVLPSAFGNIYLGETFSTYLCINNESKDIVHEIKLKAELQTSSQRFNLADTNDTPLASMDPGASNEFVISHEIKELGVHILVCLIHYTTPDGQPRSFRKFYKFQVANPLAVKTKVNNMIDGKVFLEAQVQNVSANTMLLERMRFEAAEHFNFEDLNYIQTEEDEGLQLTFGSQYLNQHDVRQYLYLLTPKNAEDDRIARTTNTLGKLDIVWRTTMGEMGRLQTSQLTRKVPILEELQVQAFNVPSTKTDETGKIIKGVKAEEPFTIGFRIRNHSSQAMRVVLSAVKTKMGSVLLSGINTRQLGELLPEQTIETTVEFFPLSPGLQKVGGLKIADAISGYAKEIDHLCDVFVEYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBV6</accession>
    <name>A0A8H7UBV6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBV6"/>
    <dbReference type="OrthoDB" id="2416617at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="53546" checksum="E163F73809AB32AC" modified="2022-01-19" version="1">MNDNLLEELMGEKADKNGGKPIDLKQDVAWDQWHDLISAEDLTDEMEQIMMNEPLPTWVDSWQNNLESPSLESSIFPHTLQDLFGGEELAAGLYDEMTFYPTQDSPVMENPELTSSDNSVTDDSQIVEIDAYQQHNSSDSESSDSDDDEDEHVEKVNASFAHDVVSDSEDEDRDFYQKAYASRGSETIPVASFMQRRQMEESILEKITHQLEAEKLPAILTIIGSDPDHQAHGGEVEIDLTRLDQNRLGRIMAYVDACVLEQQGGPVVQLCDFLIPVAPAPVVAEEFTPSAPKRKRRSKARSRDTDDDSDEDVAYTAPRKRRPAKKRSRKQSAKDTIPNTVITDDFAFGLGGSILDGPVSISTLSSVGVQKAGKSIKSKPVASIDPESIAVSRPKRRAAVHKRRMMEQLLAPSDDEEDDNQELASTQNVSLVVHSEERMDMRVTEDKVIVHESITAPVAGPLASTYVQAVVTDDEEDIDIMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCE1</accession>
    <name>A0A8H7UCE1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="17">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">INT43_005626</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
        <text evidence="17">A monovalent cation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="17"/>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCE1"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023600">
        <property type="entry name" value="Folylpolyglutamate_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038895">
        <property type="entry name" value="FPGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG2176392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="571" mass="63879" checksum="7406E1C11C2E6BA1" modified="2022-01-19" version="1">MTLARFLSSFRFQPRRPLSTSTMPFTYEEAVNKIIGLQTNAATLDALRKAGPRMNDKSLPEMRDYLRRIGYKAYPTDLDKLNLIHVTGTKGKGSTCALVQSVLRNWDSPDGKKLKTGLFTSPHLVAMRERIRINGDPISEDLFAKYTEDVWNRLEATKDQAVLDLNDPKKAIKSQLANPDKPAYFRFLTLVAFHALIQEQVDVAIFEVGVGGEYDSTNILENPIVCGITALGLDHVSVLGNTLESISWHKAGIIKNKVPVIAFDQVPEANEVIKSRAAEKDVSDYAVFSEHLDSSLMMIDCILIGTSSHCVRFQRFCFGSIMAISIYRAAFPFLLGLMGIHQRYNALLAIEICKTWLQRCKGVEFDEAQGQVPASFLKGLKEVKWPGRGQILDVQQTKYAQDVKPNTDLTWYLDGAHTAESLEVCANWFRDTVKEPTDKTTRVLVFNCTHGRDGLRLLDNIARIHKVVHFDHAVFSTNVTFKKGYTTDNANVTVAIDEKLSLQHELAESWLQLVPEFPSDHIHIVGSVEEAVLWSVDQSQKSPEGQKLQVLSTGSLIMVGNTLTVMDIPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UD67</accession>
    <name>A0A8H7UD67_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_008864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UD67"/>
    <dbReference type="OrthoDB" id="2337273at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2181281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="310" mass="35700" checksum="3DDA42457B9319A8" modified="2022-01-19" version="1">MKFSTIKMFSNLGKTKVAPVPADTKQQRSKSVDLGHGSLISMPEIAPAQFVPVAMPHDDEEHLVVRDLEPVWSYQDPDEKGKTMRFEEYNQAILEDSFHKGNESMTIQDANFQYSYVTIHLTCNPKMRRRKSDSFMSEQRRRKQARISQCNSKNELELGVNVHRTIVPVWRFSYGKRWIRFDNTNQVRLELSINRSKTLDLIDMAFPHDTLSLTFKGAPDSDVIGTMEIKRALDEKEAVEDEEDEEAEEKADGPTPIFANMQATHKLDWNYTHEMAKPVKKEGGLFEMLLDMSSESTIHTFLWPQAVEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDR9</accession>
    <name>A0A8H7UDR9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">OPT family small oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_002090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDR9"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="583"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="615"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="665"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="694"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2179240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="751" mass="84155" checksum="240B994136934581" modified="2022-01-19" version="1">MEKKDFGEKPSSPPSSLQEDGFDQSSETEKNSQFSVEDSPIEEVRGAVPPTDDTSLPTATFRAWFWGIVFSAAISFSNQFFWFRKNPLTIKVLVVQLLAYPAGRLSASIVPNWKMTLFGQTYSLNSGPFNVKEHVLITVMANAAATSFDAIDIIVVQKLYYNQSWGFGGGFLLVVTTSILGFAFAGICHRFLVRPASMVWPINLVNATLFHTLHREVPKAVAQAEKSVRGLSMSRNRMFLTVFAISFCWYFFPGYIMPVLTSISWICWIKKDSVLVSQIGSGINGLGILSFTLDWSTMTSWLPSPLAIPWVVQANMLAGFVAFIYIIIPAVYYSNAFDSKLFPMYNTNQYDQWGNAYNRSRILTPEQFLDESAYEEYSPVRITGFFAICYGQGLLALGAIVTHTVLYNGKEVLDRIRSAKQANDDIHARLMDHYPDVPHWWYAALFVVSMALSFVTIVVWPSDMPWWALIIAVIMAFVWLLPIGIVTAITSQQPTISMITEWVYGAIAPGHPIGNMIFKTYGYLVCKQALLFAQDLKLGHYMKIPPREMFTFQIIGTIIASFVSLGTTQYLMNTIPNICTNAAYPFTCPNAGLFGASSVIWGLIGPGKFFEAGTLYNPIAYFLLIGFLLPIPFYFLARKYPTSWVAKINIPVVCLGLTPYPPAPTSLMSTWVALGFIFNFYIKKYFKAWWQKYNYVISAAMDSGVAICGIVLFFALQNNEIHFSQWWGNNSDSIDECPLATANWAGVDAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UED3</accession>
    <name>A0A8H7UED3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003656</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UED3"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054498">
        <property type="entry name" value="2H-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF4">
        <property type="entry name" value="SPORULATION PROTEIN RMD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22547">
        <property type="entry name" value="2H-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034080856" description="DUF155 domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="723"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="Swiss Army Knife 2H phosphoesterase" evidence="6">
        <location>
            <begin position="63"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="5">
        <location>
            <begin position="515"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2179870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="756" mass="85312" checksum="07D8EF3962FC310A" modified="2022-01-19" version="1">MLINLGLAIIACVSANAQMQHSLQYESHSPLGIPLAGPPLSLDIRIKHSYKIPFIPHTDDLIWLGQELNYSYIEPIYEEVSRSHDSLQSRGEAHITVISPPEFAILAAANVTIDDVNKIAIEYKIQGSGFDVACLGRVQVEDNTVYQIIVHSDDLVRIRTRIFQLYWSRGGNPALFDPKKHIMQSFAESKLLSKSAPKQSIVPKLAKTVVKNAAKSSTSGSGNAVAGKAKPLRSTKTSQKLVLFPSETAESTSSYVQQDDTDQEGDVTPVVHLPLELHILGSRTVAERMTKDQRDRLSLPRVSAYCLADRFNFEEARKFLKEQHHVTPRVYDECLYAPYHFPIMTLRPGGKNSTNVRLRSAPWPETGGRMTQQEDYYHQYENDQMTYEEENLYADALENTPAEQVETASEPSTAQQTNEFYEGGHTTLEPVAENSESRYVPSGDITEPDASSTPDTIHHEPHPQEAVADFETALANEQLDPQMLKSDAEVRAEERRDSEHSTKAAHTKPFTGGELFIFDYGVLVFWNFSRAQELLMLEDLSDFAIRPLKDNPDDLEDMQIEEMHFQYDTTQKHSRIFNDMLTLKSGNHMIKLTLSHGISQSAVLARYEDIMDNTIEASYATKHIPKKLALTGKLDMKRKEMTQINGHLFKLRMNVNLSSNVLDTPEIFWSEPSLQPLYNAIRDYLEIPQRAAILNDRCTVVSDLLSMLREHMNNFGVEYQTLIIIYLIIVAVLVACVEIAVKILNQTAESPRTFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEG8</accession>
    <name>A0A8H7UEG8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_007587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEG8"/>
    <dbReference type="OrthoDB" id="21214at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031511">
        <property type="term" value="C:Mis6-Sim4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2176933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="194" mass="22573" checksum="2DA149795D069B5F" modified="2022-01-19" version="1">MSTETELTDYQQNKELLNRLVSIHETPFKLPQRFWNIREQETDSVPLDVVERAITDLNLGIKSRTQKAFSPLMIRKFVESMEHERLQKAHPKPTNHASIPSFDPRDPLSWVASTPAELDVGTTKDMTSARRIDVTSLQHIDQDSELFQEIQRTSQLTHKLITNLERLPITNMPRNDQTKQIKSIDNITKDMLWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEL1</accession>
    <name>A0A8H7UEL1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small G-protein Ras2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEL1"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="19397" checksum="0B75692191B77059" modified="2022-01-19" version="1">MMLYRLVVLGDGGVGKTYDPTIEDSYRKQVVIDDQPCVLEVLDTAGQEEYTALRDQWIRDGEGFLVVYSITSRATFDRVQGFRDQIVRVKDAQDKDIPLMLVGNKSDKVTEREISRDEGASMARKMHCEFIETSAKTCVNVERSFYSVVKLIRSQRDGQTKQKKGKCNLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UF57</accession>
    <name>A0A8H7UF57_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_006477</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UF57"/>
    <dbReference type="OrthoDB" id="206335at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005996">
        <property type="term" value="P:monosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000019">
        <property type="entry name" value="RNA exonuclease NEF-sp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1650.10">
        <property type="entry name" value="RbsD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023750">
        <property type="entry name" value="RbsD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007721">
        <property type="entry name" value="RbsD_FucU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05025">
        <property type="entry name" value="RbsD_FucU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102546">
        <property type="entry name" value="RbsD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="9">
        <location>
            <begin position="332"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="141"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2183471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="677" mass="76169" checksum="6D0F907FB5661A89" modified="2022-01-19" version="1">MQFYSEVIDGAMFFVFKAAGHGSQILITDANFPVSTATPTTATRVYLNLRPGQVSADDVLATILTAAPIEAVHVMEPSSEFTTLDHKGEVPIFDTFRELVQKQNKKLDLEKIERFAFYDFARGKNVTLAIQTARNPFTALSEGSGTTMQTEATQPSINSAKRPKKAKKPSVTIKPPNYEPPLEELRSFVMSCVCPDVPVPSWAQMSNKSLIKGAVVAYVDGLDPNFFTSDGPYLGGIFQEKIQTVMLAKSKTLLRDPFGDLTVYPLTKSAQRDREEAHRLTQLYPKDLMLTESQMKIMGLPIHSYYKPDNNIQAGWVESTIDAIRGSAKPTKLLAVDCEMCITEDGPALTRVAMLDSEGKVLIDQLVKPALPIVDYVTQWSGITVEMLRPVTTTLEDVQKLITQQLNEDTILVGHSIINDINALKVIHPFIIDTVITFPHPSGPPYKARLKWLAKRWLSKEIQVATSGHDPAEDALTCLELVDRKLEAGLNFGQFKQGQESIISYLGSRKPSKTCTILRMSSAQHFDEEIDKSEAEKYQFATNVDEMVDKAANLLNSRDLVICRFRDMEEVYYEENDGDDDKKKKLYEEFERKIKRLYEQLPGNTCLIVTSGAGNRRKYNKLMEKYMAIKSTEKQKESNEATPIHTEWTDGEEDQRRQLFQNATKGILLVAWKPLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFE2</accession>
    <name>A0A8H7UFE2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFE2"/>
    <dbReference type="OrthoDB" id="422005at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050181">
        <property type="entry name" value="Cold_shock_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11544">
        <property type="entry name" value="COLD SHOCK DOMAIN CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="227" mass="24130" checksum="15FE9270B1E860DC" modified="2022-01-19" version="1" fragment="single">MTSVSRHTGKVKFFNSVKGFGFIIPDDQAGQDDIEEVFVHHTAIQNDGGFKSLGEVEYDLVQGPKGMQASNVSGPGGVSVKGDPNAGRRPFESRYDRYGGGPPSGRFGPYGNVYGDIGPYGMPQNQAAFPYNMTPYGMYGQQFPTGASGAAPPQQQQQQQQPQQRPGGPFSPLGSPIGYQSYPPQFAQFGQQPGPPMSGSTGAYHQGYQDRSQQQPHSSASSNSGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGE7</accession>
    <name>A0A8H7UGE7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MCM7</name>
        <name evidence="14" type="ORF">INT43_000734</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGE7"/>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="348"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2184821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="745" mass="84811" checksum="2F4B37262766E5EA" modified="2022-01-19" version="1">MAALNPYKLDIDYVRESDACKEFLQNYVDKQHISSDMELDTRKPNCSLYPVQQQVVDRDETRITIDLEDFAKYEDSDLRTVRNITRNTKRYTEIFSKVIDQLSAELVPRSSELNYKDSVLDVIINQRKIRDENRPAEAGEPFPASLTRRYEVYFKPMHQQLPQAVRQINGSQLGNLVTVRGIITRVSDVRPCLQVNAYSCDTCGHELFQEVTQRQFTPLTECDSEVCKKHKSRGKLFMQTRASKFLSFQEVKLQELTDQVPVGHIPRTMSIHLYGELCRSLNPGDVCNIAGIFLPLPYTGFRAMRAGLLTDTYLEAQHIHRLKKQYDQMELTPEIEAKLAELERDPDIYNKLARSIAPEIYGHEDVKKALLLLLVGGVTKTVGDGMKIRGDINICLMGDPGVAKSQLLKFIAKVAPRGVYTTGRGSSGVGLTAAVMRDPITDEMVLEGGALVLADNGICCIDEFDKMDDSDRTAIHEVMEQQTISISKAGITTTLNARTSILSAANPLYGRYNARISPVQNINLPAALLSRFDILFLILDRPSDDMDRRLAEHVTYVHTHNMHPRQEHEYLEPNMIRHYVAHARSKRPILTPQVSEYITSIYVQMRKQQKADEDKDQQFTYSSARTLLGIVRTAQALARIRLSDIVETGDVDEAIRIIDVSKASLYDDDDIEERAHDRTFLTGILNVVRTMREQIGTNELNMSTVQQRVRSRGYTEQQFENAIREYSQLDIWQVNANRTKLTIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGP0</accession>
    <name>A0A8H7UGP0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sucrase/ferredoxin-like-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_007305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGP0"/>
    <dbReference type="OrthoDB" id="10253744at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF14">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2182375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="35230" checksum="354FD578A71E1592" modified="2022-01-19" version="1">MSRAFRPQALRNIFIRRYSRIPFDERPFPFSRFEPCCPEAAEKTASNGFQPCKVHPFPEVIGRKVDFETDMTRLKGTNSHMVVCVGEDGPEWHKAKVEKVKLGMVEAIEDAKKEGHSIFSRGSHMPAGSNTLLTICDRERIQDNESNIPWPASDVLLFPSFQVAKAVDPSNPHFKNFLQSAWSSEKQNLEAVQPYIKVEDLKKTTQAVVLVCTHRMRDARCGVLGPLLVEELKRSLKEKGLHGEEAKKSGTHVDVFGTSHFGGHKFAGNLIIHSPELGGHMYGNIRACHVDTLIDRHIIEGKVIRELWRGVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGS5</accession>
    <name>A0A8H7UGS5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_008684</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGS5"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10291">
        <property type="entry name" value="GST_C_YfcG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="4"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="94"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2181102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25895" checksum="EBAF8841DA4D98D6" modified="2022-01-19" version="1">MAQKHPITLYTMGTPNGIKASITLEELQVPYNVEAIDISKNTQKEDWFIKINPNGRIPAIVDHSKNDFNVFETGAIMTYLCDFYDPQHRLMPEDPLARSKVMQFLMFQMGGIGPMQGQANHFVRYAPEKIPYAQKRYIDETKRLYGVLEIALEGTDYLANNQYSIADIANYSWVICHGLLGIDINEFPRVKAWLKRIDERPAVQKGLRVPNERLATMLAELENKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHN4</accession>
    <name>A0A8H7UHN4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_004007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHN4"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2180218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="73" mass="8446" checksum="FB13B317DE4CFC65" modified="2022-01-19" version="1">MSAPVASKSTENTTKPEDTKSAPQLGALEEDDEFEEFAAEDWEETEEDTEDAHFWEDNWDDDDVEDDFSKQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHU2</accession>
    <name>A0A8H7UHU2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="4 11">2.7.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_006628</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the APS kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="4 11"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHU2"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000212">
        <property type="entry name" value="Adenylyl-sulfate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF1">
        <property type="entry name" value="PAPS SYNTHETASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APS kinase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2183620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="205" mass="22680" checksum="ADEE28412B05924A" modified="2022-01-19" version="1">MATNITWHQGHVSKEERETLLGQKGLTIWFTGLSASGKSTLATALEQTLLHAKISSYRLDGDNIRFGLNKNLGFGPDDRTENIRRIAEVAKLFADSTSIALTAFISPYRADRDAARKLHQDAGIPFIEVYADAPLDVVESRDPKGLYKKAKAGEIKEFTGISAPYEEPLAAEVHIRTDQMSIEEGVQKIIEYLVANGYVDNSKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIB7</accession>
    <name>A0A8H7UIB7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Ribosomal RNA-processing protein 8</fullName>
            <ecNumber evidence="13">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_008473</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
            <location evidence="1 13">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the methyltransferase superfamily. RRP8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="13"/>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIB7"/>
    <dbReference type="OrthoDB" id="10258825at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2150:FF:000001">
        <property type="entry name" value="Ribosomal RNA-processing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000068">
        <property type="entry name" value="Ribosomal RNA-processing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2150">
        <property type="entry name" value="Ribosomal RNA-processing protein 8, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007823">
        <property type="entry name" value="RRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042036">
        <property type="entry name" value="RRP8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05148">
        <property type="entry name" value="Methyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 13" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="21"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="293"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="261"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2180893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="596" mass="66331" checksum="ADA28527E2E51927" modified="2022-01-19" version="1">MQGLFDAPGWNLGTIAAEKPAKLSKTQQKKAFKKKKMVEEALGQAPPRRPRVKNEAAAEDNASGDSNKRKPDSNQKGDTEKLNKKQRVDGTQKENDTSNKPFKSNGQNIHEAKGFQNTKNAEPELSIGQGKNRSNYVSVMTADEPIVANTSSMSEPMISVSNEEQPKSNGKLAKKKKARAEKAAEQPKAKDQPTTTEQHKEDERTHASEPVQAAEQPKAAERPKTAEQSKAVDASASPKPEGEIVLSKTQQKKLARQKMIQAKEAKKPKADTESPEIKQVAPTLIKKVNENQKKKLQAALAKSASSQNAQIEKAKSQVTEEKNAPKPQISPVETPAKQQPKLTPLQQKMKEKLSGSRFRWLNEQLYTTPGDEAFTLFQEKPELFDHYHEGFRHQVESWPTNPVDVMIDYLRTMPTSTVVADFGCGDAKIAHTLTKHKVLSFDLVAKNDKVVACDIAKLPLPDGLVDVAIFCLSLMGTNYVDFVREAHRVLKEGGELKVAEVISRFSDVDAFIQLMEELGFEFMDKDDSNKMFILLDFVKKPEYGALDAEDSEVMKGLNKKQKKAFQKGLGGSKSKNPEKMNRLAQDLLKPCLYKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJ13</accession>
    <name>A0A8H7UJ13_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat shock 70 kDa protein 12A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJ13"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2180819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="70382" checksum="F996842BCDA703E8" modified="2022-01-19" version="1" fragment="single">SPSLEFRRAASFMADQRVFNERDYPVVVGIDFGRVECNWIIAYIPILMVALTHFRHNILRSRVFAGQSRRYRRHCEMVSIAQAFYEETEIVQLRWVSVKFANLRVCTSDVSTNCCFQTPTMNKLVQWGNAARLELLRPINRDAVLLKQYKLYLDEALSKDLVPLPNDLTIVDVISDFLREFHDHLIFEMSRGIAREFKQDSFRYCLTVPAMWSDRAKALMREAAINAGLIKETDHRDRLMLISEPEAAAIYCEKKCEQFNLSNEDRFMICDAGGGTVDLIVFKVETTFQGTRKFKEDTKGHGESCGSIFIDKRMRKLLKRKLKVATKSVPPYAFEHMMDSFINTVKPEFDGTDDHFIQLPASLELSSLTNEEIGLDEGVLCLTMQELRDEVFEPVVQDVLKLIRQQRSTVDRLEAIFLVGGFGSSNYLFKRVQQEFGSEVPLVGVPPRAELAVTRGAVYFGKNPNLVTTRVPRYWYGIDSTNKFIEGLDPPEFKIIRNDGSIRADNRFSIFVRRGVPLDINDCVVKKYYAFYPNQTVCSLFAADTEEEPRYTCAPTMGVRRIANFTIPMPKLPDVQYGERIDLLIKMYFGEVELRVEAVIQGKTYSTTCMFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJY2</accession>
    <name>A0A8H7UJY2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_000416</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJY2"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="35"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2184507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="148" mass="16479" checksum="C044D278D690ED24" modified="2022-01-19" version="1">MSETAEPPLPTLKHASLLSVLDNSIVVQNEGSMARDQFANERTWLSWTKLACTLIVLGFTIIMNLRLPSADPSNPSIDERYTKPIGITFVAIGLVAYMCGLIKYFKNLRLLIQHRTLVQAGWISFLLMGIVSIFTCTLMLIIISNHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UK66</accession>
    <name>A0A8H7UK66_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="8">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_000675</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="8"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UK66"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000004">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF4">
        <property type="entry name" value="INOSITOL-1-MONOPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2184762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="334" mass="36419" checksum="1D3479C678D9B51F" modified="2022-01-19" version="1">MSASELSEYLTFATDLAKQAGTLIKEGVDKRFAGSGSIMAKYSNPSDMVTETDQAVEAFIKEKIFKAYPNHKSAANMYFYNARFIGEETFAAGEKPSFTDVPTWIVDPIDGTTNFIHGYPFVCVSIGLTVNKLPVVGVIYNPLLNELYTAAHGQGAYLNQTTRLPLFDPKNIAPLNDLSECLVMTEMGADRSAAVISRKIDTIHNLVASPQDPGKRAIIQNSVGTQAHSIRSTGSAALNLCCVAKGVADVFWEIGCWEWDVCAAIVVLREAGGITLDGLKPSDEEVNIFCRRYLAIRPTGDKDSQLKIARQFWSLVPKEGIRAPRDAVPGGYEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKE8</accession>
    <name>A0A8H7UKE8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_002848</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKE8"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="53"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2186410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="480" mass="51756" checksum="379FD6E0EDB03982" modified="2022-01-19" version="1">MPAPLQHKESSNDTLHDDASSSNRFDGAIPSSMSIDSATEETPKQQLRRKIFPILQCFFAVALMGLQDGNFGVILPRIRASYGVSDGLVSILFLLQAGGYFVMAFCNGLVVAKIGQKGALYLGASLMLVSYILLLFGFPFPAMGCIMIILGCGLALTNAGTNVYIITAPYRTIVLNLLHASYGTGALIGPLMSSALLAKDLRWEVSYMILAGVASLNLIGMIACFWHTKIDTHDDPAIESLALNPESTSRPESMIKQALRQRITQVGAFYLLFYVGTEVTFGSWSFTFLTEVRGGDPVHLAQVTSGYWAGLTFGRLFLGAVTAHFGENRMVALYLIITCMMIVVVWQVTAIAGDIFGLVVIGMALGPMFPTTISVASQVLPKHLHTTVIGFLAALGQGGAALFPFITGEIASTAGVIGMMPFTLALTVSMLISWIFMPNVGPPLWPFSKKRRGSDRGNSIVDTIVVDEEKTNSRKQSLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKU4</accession>
    <name>A0A8H7UKU4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="5">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_006494</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="5"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKU4"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07130">
        <property type="entry name" value="ALDH_F7_AASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000018">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044638">
        <property type="entry name" value="ALDH7A1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43521">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43521:SF1">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="64"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2183488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="543" mass="58046" checksum="52299465963026FF" modified="2022-01-19" version="1">MASRILNRSSLLAATNAALKTSKVLKPTTIRSLSTYDKHKDVLEALGISKQNKGVFDGEWKGSGSVMQSINPVNNEVIAEVTTGSVQDMDTALDKVVEAQKIWREYTIPQRGQVLLAMRNALAANLQPLGKLVALEMGKILPEGVGEVQEYVDVLDYALGLSRSMSGSFIPSERPGHAMIETWNPLGVTGVISAFNFPVAVYGWNQAIAFVTGNGVIWKPSPTTPLCSLAITTLLEKVLREQNLPPSLCSLVTGGTEVGHKLVTDKRANLISFTGSTAVGKKVGITVQERFGKHILELGGNNAIIVTEDADIEMASRAILFAAVGTAGQRCTTARRLIVQESVYDKLVGKLKEAYKQVKVGDPLDQGILCGPLHTKSAVEAYEKALKDIKAQGGDILYGGAVIKDGELAKGNFVMPTLTSVTADMDVVKNEVFVPILHTMKYKTFDEAIHMNNNVAQGLSSSVFTSDPAKIFKWIGPAGSDCGIINVNIPTNGAEIGGAFGGEKETGGGRESGSDSWKQYCRRGTCTINYSGQLPLAQGINFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UMP9</accession>
    <name>A0A8H7UMP9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_000373</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UMP9"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19528">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000004">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000001">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="7">
        <location>
            <begin position="33"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="6">
        <location>
            <begin position="133"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="245"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="518"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="719"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="784"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="728"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2184464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="823" mass="90789" checksum="F9F7B3BA5B52336B" modified="2022-01-19" version="1">MAAEPNAGIEASDVDPAHDPATAILRRKSARNKLIVDDDSNDDNSVMTLSTATMEALQLFKGDVALIKGKKRRDTVLIVLADDDLEDNKVRINKVVRNNLRIRLGDVVSIHPCPDIKFGKRIHVLPIDDTVEGLTGNLFETYLKPYFLEAYRPIRKGDLFLVRGSMRAVEFKVVETDPDDYCIVAQDTVIHCEGEPIKREDEESNLADVGYDDIGGCRKQMAQIRELVELPLRHPQLFKSIGIKPPRGILMYGPPGTGKTLMARAVANETGAFFFLINGPEIMSKMAGESESNLRKAFEEAEKNAPSIIFIDEIDAIAPKREKTNGEVERRVVSQLLTLMDGMKARSNIVVMAATNRPNSIDPALRRFGRFDREVDIGIPDPTGRLEILRIHTKNMKLDDDVDLEQIASETHGYVGSDVASLCSEAAMQQIREKMDLIDLEEESIDAEVLDSLAVTMENFRYALGVSNPSALRETVVEVPTVTWNDIGGLEKVKQELQETVQYPVEHPEKFLKFGMSPSKGVLFYGPPGTGKTMLAKAIANECQANFISIKGPELLTMWFGESEANVRDVFDKARAAAPCVMFFDELDSIAKARGGSSGDAGGAGDRVLNQILTEMDGMNAKKNVFVIGATNRPDQIDPALLRPGRLDQLIYIPLPDEVSRLSILTANLRKSPVASDVDLNFLAKNTHGFSGADLAEICQRAAKLAIREDIDKDIQRERERKARQEAGEDVGMDEDEEDDGVAEISRLHFEEAMAFARRSVSDNDIRKYEMFSQNLQQQRGFGNNFKFPESGGAGPNSGAQGMDGVSANTGFGEEGGDDDLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCN0</accession>
    <name>A0A8H7PCN0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_009096</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCN0"/>
    <dbReference type="OrthoDB" id="4217619at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06719">
        <property type="entry name" value="PDZ2-4_Nma111p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025926">
        <property type="entry name" value="PDZ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46366:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN C1685.05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46366">
        <property type="entry name" value="PRO-APOPTOTIC SERINE PROTEASE NMA111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12812">
        <property type="entry name" value="PDZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="311"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="792"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="879"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2171435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1034" mass="114113" checksum="816F4A7EE06234BE" modified="2022-01-19" version="1">MTPSLLTYITKPHFERESKQPPRPPLVRQRSKSIPWESTPRPFDKSNDDLFRGVDHVLLRNPLPATQAGPLTPPQPVLDTQSWERTLERSIKSIVSIKASHVRSFDTETAGSYTATGFVVDAKRGLVLSNRHVVSPAPIVAQAVLVNYEEVDLKPIYRDPVHDFGVLQFDPSKVKFMDLEEIPLSPERAKVGLDIRVVGNDAGEKLSILAGTLARLDRRAPFYGTGEYNDWNTFYIQAASGTSGGSSGSPVLDIHGHAVALNAGGASKASSSFYLPLDRVKRALKYIQDGLPVPRGTLQTEFEHIPYDEAHRLGLRSSVEQKIRKRFPQETGLLVVRQLLRSGPADGILMSGDILISCNGTFVSNFIDLFAVIDDSVNKDITLTISRASHLMQVTLKVQDLHSITPDCFVEVGGGVVNELSYQLAKSYGIPVGGVYVASSGHMLATASAWRKSVIVSVNNIPTPHLDDFINVMKTLPDGARVPIKYWTLSKAYKHKIMLMHVDKHWSPFRVAKRNDQTGLWEYQAVESTLTKFYQQPATASFPALDSSLKLAEILQPSIVHVDFNLPFLIDGISNTHYYGTGIVLSTNPPLVICDRDTVPMAIGDIHINFANSISLNGKLEFLHPFYNYALLSYDSSLIGDTPIKPIKMSKKSLRQGSSTTFIGLSGDQTLLMKHTTVSSTGNVGTRECSPPRWRSMNVETIKVDDSIASQGGVLVDETDGGVQALWFSFSSQNDSGKDVQFMSGLPVDVVQPMIEKYMAGDSSIRAVDAEFWTMGVSSARDLGVPANWIKKIESIEGSKHKFFYVLNLTDVLSPCASILKVGDVILQVNEEVVNSMADLNRLMDTEMVEMVVFRDMKELTLKVPTTRFAGMETERIIGWQGALIQEPYRAVREQVSRVPGGIYVSCTLYGSPASSALRPGVWITEVQGKPVTDLNSFIEAVKNMPTSPAYTPVSERSSISEPATPFAGNDDDDLFRSLEEDHDVVAEGYVRLKTVTRQEDTTIGIMKLDNHYWGLWQITADRSAPSGWVCENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCN1</accession>
    <name>A0A8H7PCN1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Membrane protein PTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_009123</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LU7TM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCN1"/>
    <dbReference type="OrthoDB" id="19932at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053938">
        <property type="entry name" value="PTM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21902">
        <property type="entry name" value="PTM1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034866526" description="Membrane protein PTM1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="PTM1-like N-terminal" evidence="11">
        <location>
            <begin position="31"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="10">
        <location>
            <begin position="182"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="471"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2171462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="60655" checksum="F83B627E339F22D2" modified="2022-01-19" version="1">MLSKLLVALGSLAVVAMAAEVPLSSNDESATTCSGMWSKSAFPGGTDPYIKVGFDSTSEGDVAVLIYEWSDYSKIGAFDNNTMELRYICDAEAIADHLCTQAELGTFIINVPENQRNTTSIFDHLFTLTPNDTDGTIYEISKTGYYCVAIVPVENSSGALGKFDAWVEWRFPYGELPAVDYPKLMFYGLFALIYLVIGIYWGIQTFRYWRDILPVQNYISGFIFFLAVEMAFNWGYWESYNQTGRTCNISFFMLLIVCMGYGVVRPSLGSTMRKCVILASTHFFFGVLYVIGTMLMKPEDDGFFLVFLVIFPLSTTMTAFYIWTLNSINGTLAILDIRKQHVKALMYKRLYRLLVFSVCMVIALFVLNILNFGSRLSPDWPAKNWKRRWFMLDGWLNILYFTVFFVIVILWRPTENNARYGLEQLSQDEDEAMDLENRLRRAEGLGYDGMKGRGNGDGRMMDEDAAIFELGDEDSDEEDGNRVKLMSVGGSSQAREPPRRDLSGAGEHGGLLDSEDHDDDIDDSDTARLTQNQKMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDL8</accession>
    <name>A0A8H7PDL8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_009097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDL8"/>
    <dbReference type="OrthoDB" id="2155291at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF17">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN RGD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="418"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="715"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="753" mass="85660" checksum="38D43D5F27FF1724" modified="2022-01-19" version="1">MTTVHFHHAFWYRPTKMDDYKNPPDFRAGLNVLHERLAHSELENQDIIRHVRARIESERVYAEHLTSLETMEFLSRDQETGLSQCFSMIRRESTELASSHHRLAQEIATMVLQPLIRLENKYRRVTQSGYDSIDAQIRQFETLFKPLQKLRQARDKRFVEAEAFLSSTSEKDAIDWAGQSFSRAQFGKTIANIKASVLPIKPAGHPVSISYDSLIEYLIKTKITGSERDAKQAIDRLLDLHVLKTVSDQQEGIQTFYQFTDGEVDLHPISPNTPTSKITGILGMWQQPSQDENTRIRLVSIYEGADEAFRTAVEKADGMRLIVEEAMFAHLDEMENIELERIRGLKQAFTTLAATMSNIIPNCKDIYDRLMLYQETLRPDADVQYIVEQYRTARFCPRPILYLDYHNRPTTADRNFGLPLETVTENSILRIPKIMQEGIQQLDTKISVIWTTDVPLDRVHEARAELNVDDSSIDQDKLKKYDPLLLASVLRLYLQELPECLLTFDLYDPVKVLYADSSLDTDTRIKSISNLLSTLPASNYQTTEILFRHLHRLTAGCQAPINEKLSTKLSIVLGPILLRPRVDSTLTVHDKCPHRLVKDLIDHCDNIFSETAHESHQNNIQRTALVAPHDYTNTPIPTRRNTILSYFKGSSKSAMDEPITIIPTTPAPAMSSHKPRPPIAPPRSSTLFEMDGRGSPSKEVFRRSSDTSLISKRPSMSTSVSTSQSSGSVDMDPAPTMMSPISIDNIDAFFDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDS1</accession>
    <name>A0A8H7PDS1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDS1"/>
    <dbReference type="OrthoDB" id="2411349at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="133" mass="14921" checksum="F4F639E6CA0EBC85" modified="2022-01-19" version="1">MQHIRWLHFEKLLLGNFSRLTSLINFSFTHINHKSTMRFFALSAIAALFAAVSVSATDERLDYKLKKGQTVDQFCSKWNDACESYIHSKYPSSSPGVYCEAGPFSGQVQVYCQGMVITQFTTKVAKQIGATPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PE92</accession>
    <name>A0A8H7PE92_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_001537</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PE92"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="99"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="205"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="165"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="264"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="498"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="526"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2172060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="537" mass="59179" checksum="B8838E9085AEDB4D" modified="2022-01-19" version="1">MTPRWEHYNKPSTATSVDSCHKMPLEEPQQRLFESKSGLSPTAGAEASFSDRTQPSTTSADRFDKPNVTSSSSVNHPHAEPCNSSVARSDIGIGSVVACTNCGVTATPLWRRAPTGEIICNACGLYLKARNATRPTWLKRNTFARKNVNASKLQHRFVLQEQTKTLKEKPETIHHHQQQQELDVQRDEELSHDSHESSSDASSMDRPQMVCSNCSTTTTPLWRRDEEGNTICNACGLYYKLHNVQRPVTMKRSVIKRRKRVHANIISPPPPHHHHHHHHATAQPIQQRRLCPKHSEPPMLTHDSSSSGSDEEETNERKRRFYEDGFRTVKRMQLDDRKAPEALEPTSLHHSPSPIASLLNPVNGQHDSYRKSNTATAAAAIATVSTLLNPHSDVQQTQKVLEAHRQELRREVEHLGNLLSKTHAVLDNLDQVMVNAGIESSPQHRPAPSASGFSPNAAASILGNLLGGGDPNATNALATILTLGAAAAAAQKESIHLAPLKSPSSPPCHRELPPTPPPCPILPYPMDRRTSASSDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEU2</accession>
    <name>A0A8H7PEU2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_004917</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEU2"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="5">
        <location>
            <begin position="6"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2172375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="418" mass="47343" checksum="785256CA7D6F1F4C" modified="2022-01-19" version="1">MTSLLEPFEVPSLSNEQLKILRERLESVIWPHELDESEKVGWTYGAPTWAVKRVVDHWLHKFDWEKERMQINQFKHYKMNVDGLKVHLIHEPSPNPKAKPLVLIHGWPGSFCEFRKIIAPLRDGDGGKQIEAFHVVVVSLPGFGFSDAPTRKGFGIAQTAKTINQVMINLGYHQYIAQGGDWGSLIGRWLGVNHSKNCKAYHTNMPIPIPPLPLPTNILTRPLSVVRMLASGLTGFNYFYPEKPKILMGTGFANATWDSDAGYRAIQATKPYTLGYGLTDSPVGLMAWILEKFHVWTHHEGDSESVVLPPTISYDEFLTNVTVYWMTNTIASSTRIYYEYHNLWEGKNNLNKVPVPTAAAAFQSEIIKVPEDWIAPSCDLQQYTSYKVGGHFAAMEQSQLLVDDIQRFGALLTRKHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PF43</accession>
    <name>A0A8H7PF43_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SURF6-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_000134</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PF43"/>
    <dbReference type="OrthoDB" id="444809at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029190">
        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029188">
        <property type="entry name" value="Rrp14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007019">
        <property type="entry name" value="SURF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369:SF0">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15459">
        <property type="entry name" value="RRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04935">
        <property type="entry name" value="SURF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 14 N-terminal" evidence="7">
        <location>
            <begin position="13"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal" evidence="6">
        <location>
            <begin position="196"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="270"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2172787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="46977" checksum="9063041BFDDD0053" modified="2022-01-19" version="1">MPQDYSLGALEQRLESHVQTFDTLLKLIPAKYYITDHSEDHKPSKFMHNKRKQAPKQAIKEATKKAKKAKLDPESHKSVAEIQEEAAQRKKDESESESEAEEEDADIEEDDEEDGDMDMAEANFASLGNGIESDEDENMDEPQEKTSAADASAPITPMLKTDISELKDRLHKRIADLRKNRNAPGSDASNPKSRESILQSRMKRKQDRKKSLQAKKEQRGNGDVNEEIIKESQPAANKSNQKFSASSIKDDGDVYFGRIETGLAKKKKGATDVKTQLKQVEAKHQKLEKLRQEDKDRAAALEEKETWNKALSMAQGEKVKDDIKLLKKTIKRDEHVKLKSSKTWNERKDKIKKEEADKQKKRNANIQTRIDAKKEKRLSKGKKTKARPGFEGKGGKGKKTTQKKGSKPSFNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFB5</accession>
    <name>A0A8H7PFB5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Periplasmic binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFB5"/>
    <dbReference type="OrthoDB" id="409848at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38360:SF1">
        <property type="entry name" value="F12P19.7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38360">
        <property type="entry name" value="OS03G0120000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2172902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="50999" checksum="8ABA6CB5BCEBDFAC" modified="2022-01-19" version="1">MRLAYLKARVIPFNAEGVICEEFGSIVIDIVGPGRLYGATNSCNGFTVTDVQKDQYILIDNLLAQKSYVLLPQGVSKPAGLNDSVIPVTVPISAAYADTLDVLGFAELLNISSSFVAASPDVVTAHTSPCFNFTGGATSEYIFTSSAASTANKTIVFSASDLSLTPTQKMMWINYLAYFFGKQNQALSISSVINKNYQCVKDRVTAGVKEKYAIAWTQAEPTANQFTLKDDTYIKTLIQDAAAVPVAVNSAQESNFSNAASFHIALQGADMLIDTTPLSDGQSYTDWLNIMQFTQGLDIFLDKEAFIQNKNVFRTGGLVSASGYPDYPERYAARPDIALMDVVAMQYPTFQPSYNMTWIYNFAQSGPVRQMSQLTNYTCGNANAMLQGITACDNLNGDPFVPPSTQVAPTNDTETENSQSSAPQGLSAGSKAGIAVGVIAGVAAVAGGAYMFWRKRKTFSEPSHNFYKMDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFG6</accession>
    <name>A0A8H7PFG6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_004893</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFG6"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="80"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2172351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="275" mass="31784" checksum="ECCFA7B6CDBF455A" modified="2022-01-19" version="1">MTMSNLQQLSSIRDALKAELNNSQPNMSKCAQMLTQLKIGLTEIGAYIPQGEQVDQNALLLARDVLETGAYYSVRVKDIAAFERYISQLNTFYFDYALIIVSNTRSILPQSEQMYPLTGLNLLRLLSQNRLSEFHTALEVIDPEQLHNNPYIKQAVDLEQFLMEGSYNKVWRNRSKVKGEEFLVFYNILIDTIRHEIANCSEKAYDALPIQDAATLLFMKNMEEVLNFAQERNWRVNPAEQKIYFANTDDEVTEIPQEQIIKQTLAYARELERIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFQ9</accession>
    <name>A0A8H7PFQ9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_000184</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFQ9"/>
    <dbReference type="OrthoDB" id="268479at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03757">
        <property type="entry name" value="proteasome_beta_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000027">
        <property type="entry name" value="Proteasome subunit beta type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2172834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="237" mass="26436" checksum="A382CD2571F9009F" modified="2022-01-19" version="1" fragment="single">ILNMNFMDSPLSKPAPYLAAPIEHRFEPYEDNGGTSVAIAGKDFCVVASDTRQSNGYIINSRNSPKAYKMSSTAVLSCNGFHADGLTLKKVLEQRMKMYKFNHDKEMSVTALAQMLSNTLYQRRFFPYYAFCLLGGVDSEGKGAVYCYDAIGSFERESYRTSGSASALIQPFLDNQVGRKNQQNVSKEPLDLETVLRITKDAFAGATERDIHTGDSLQIYIITKDGVEEQSYPLKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGT2</accession>
    <name>A0A8H7PGT2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_005134</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGT2"/>
    <dbReference type="OrthoDB" id="282152at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="4"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2173714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="107" mass="12185" checksum="885DA15F57DF843A" modified="2022-01-19" version="1">MLFCPSCANILLVDSNGGQAFQCQTCPYTFRIRQTHTSKKELVRKELDDVLGGAAAWENVDSVEIECDKCGHGRAYFMQIQIRSADEPSSIFYKCCNEKCQHQWREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PH10</accession>
    <name>A0A8H7PH10_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_004504</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020972at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056026">
        <property type="entry name" value="DUF7607"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF1">
        <property type="entry name" value="HELICASE ARIP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24580">
        <property type="entry name" value="DUF7607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="11">
        <location>
            <begin position="9"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="687"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="1223"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="241"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="303"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="533"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1057"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1492"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1579"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1683"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="623"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1069"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1116"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1151"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1521"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1586"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1683"/>
            <end position="1713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2173131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1728" mass="196021" checksum="4FA1BEFC708F7D35" modified="2022-01-19" version="1">MTQLSPWAWKKEHVKEWASTEFGDPIAEVFEENDVDGGLLLVEVSEEVLRESFFIESWGMRKRILLAINGLLQKFPTPGAINEDIGAYKESSAIDSISERPQVHRVQMTRPQLLSAEEIYQYLNTYMKAELIPKWENEKKPILEQSAARFWMKHHATRKKFIEQAEASYTYILRYRLPRICEALVLAGMTRTSDLRRMSLSLEAAMFDARKLMWQIEILKGDRPETKDVVIHKPETVKHVVKDAESSDESLKSEGEISLEENSDDTSDGEAIAMGTSDDDDFDDFIEYDDEPRKSVFDYRVIGTSSPKSEDDNTEVSEGQNVSESDSATEIDDGEKHQDTESNASSLKNRIQNKSSKRRTRHHDNSHNRNRKRRKRSQSMTGEREEDSTQSSTVPFESDSDDDDFSDMNGSNYHSILDLNRHVRRTSTPTSSSLPVEELASLELRDFSKLIKAVVQTSDTQFINAYNELKVEDPHNIHSGDKAIMREVDIGLSLFNTMNATNEEYLSLDEQGRLLAFIQHIVALEAASLPQTRSRRRLRRRRRNYSHSSDSDSELDSADDELLSVATLTDEAITGEDEDEDEDEVEVEVAESVENSPKVQHAEPKKAFFRKVRDDTAQVSAVQSSWKRKLQEAEDRAEAQLQALDETTENVIVNIGDADTAKHVILLPHLAQVMKPHQIEGIRFMWRQTMMLKTGGVLGHAMGLGKTLQVIAFVYTIFQEIALKNKDLPDLVKPGRILILAPVTTLKNWHNEFYKWIPKSKRRMIRDVINLAEMRFMPSKQRYGLIEEWYNKGGVLLMGYDNFRSCVKLSQNEDVFKWLQKPGPSLTIIDEGHKIKNAKSQLSTVVKNIETPFRLCMTGYPLQNNLEEYYVMIDFIYPGFLGTIGEFRNAYKNPIEHFYEDTTPAEMMISKRQLYKLRRLLADLIHRYVFLVRDAEILHRELRRKTEFDVCCKLTEEQRQIYELCVDDLRAAYKLQPIQALQVFRNICNHPAAFLQQTRIAQQAASQKRVENMKSNTIISMFKHMTDVNTQEAGSNGFMSQSQVVDTVEAETTSIHIQSSPHLSPAIDNRNSPTVNNTGNHQAGLNEHTGPSTTISTHTNAEQQLSSHEAEVVEADTTSPQTMEQSNASSPSYTPHSPIMPYQPSLDRYNFSASGSPSQQGSIPVNSRPAADNSNTQVMSNMTTVIDDEETALPEEYKSVFSNASALVQSMSGNIELSCKCKVALQLIKQCIEAGDKTLLFSHTIPTLDYLEKILKDANIHTLRIDGSTPTPTRQIYVDKFNRQHKWQVFLVSSKAASLGINLVAANRVILFDLDWNPCHDEQAVARAYRFGQQKEVFVYRMQTFGTIEEHIFRLNVHKHGISSRVVDDKTLMPQKQDLKKKYYQKPVPSPGMPLPEGTYSHLADSVLRATAEICKDDLVNIELHSTYTSEYEQEGLNEQDKQEIEQQLSFEQRIRNGEIIPSTVPPPPQATISAFEPIRQPYDMYPLTSAPGATTFNDRDTITLGSSKSAPIDLDDASPVVSSGTQTQHNYSPIPSKLSSALATASDVHQANYADSYGAERESDSIYLPALGASDLLDYPDDLRSSQGQSQIQSQSQSQSQSQSQSQSQSQSHSRPLEQLSRHYKQFYDAINESQNTSMRSSPQHKFNIEHQRQPWPQHEWSSHDSLRRPLPVHYHTNVALSNSRPISGVQPTQQALPNQSENQMSQKNLSLANPPKSFLNPSPDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHT3</accession>
    <name>A0A8H7PHT3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">cystathionine gamma-synthase</fullName>
            <ecNumber evidence="9">2.5.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">O-succinylhomoserine (thiol)-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_004322</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-succinyl-L-homoserine + L-cysteine = L,L-cystathionine + succinate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20397"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57661"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="EC" id="2.5.1.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.48" evidence="9"/>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHT3"/>
    <dbReference type="OrthoDB" id="10047078at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000111">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000063">
        <property type="entry name" value="Probable cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="236"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2174299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="661" mass="74720" checksum="3A09C234AF21D898" modified="2022-01-19" version="1">MVNNYEQRRDWHFHLDLGNSKGQSDNQKSLTYLHFGPTMSTVSYEPPTQVGATIPINEPHAVSVSLPKWKDNIDYEEGAPRVISAMQLGYPRFFIHPTIQKQLLTSNHSYCNALKLAKRLLEKFGTKDQLNLLLPSRSIARRCRAFIQKYYTPDDKRLLNEIRIVEFEIAPISPSSEMKSVPLHIVLFPSEAFKFAKTFWQHTGDIISSRMAEYALRVLDENAELEIKGVSNGSADAVNFAPRPKSRSHRHYSRKTSVTESLSTPKTENPDHEHLTYVEERYGRNLNLMFAEKAKVALRRRIAGVMTESEQSMKVEDLVESALVIDEQKKRQGDRNVTGLSESDVYLFPCGMSAIFNAHRFAMGALDATRKSVCYGFPYTDTLKILEKFGPGCIFYGLGEEKDIDDLQSKLEAGERFLALFCECPSNPLLKTPNLKRLRALADKYDFLIIIDETIGNFANVRVLQHADIVVSSLTKVFSGDSNVMGGSLVLNPNGNSYDALKTYVDAEYEDLMWCEDAIFMERNSRSFKERSTTINANTEALCEILRKHPKVKDVYYPKYICNDNYEALKTPDGGYGGLFSIVLDTEEDASAFYDNLACAKGPSLGTNFTLASPYAILAHYTELDWALEFGVPRHLIRVSVGLEDREKLLNIFESALNATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHX8</accession>
    <name>A0A8H7PHX8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHX8"/>
    <dbReference type="OrthoDB" id="2310775at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2174332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="100" mass="11088" checksum="858B2E0D71148435" modified="2022-01-19" version="1">MPLPVPKAANTEPGVLPTGDAYHKLHEFLQDHRAAQQISIDDDHYQKGLVCAVNEDGKRNAVVLNIDRQGISSYLRQAGYEQTGKVPDSTAEIFKRQTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJ37</accession>
    <name>A0A8H7PJ37_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">mitochondrial processing peptidase</fullName>
            <ecNumber evidence="5">3.4.24.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Beta-MPP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_004232</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. Preferentially, cleaves after an arginine at position P2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.</text>
            <dbReference type="EC" id="3.4.24.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="5"/>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJ37"/>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000002">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000001">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="16">
        <location>
            <begin position="46"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="17">
        <location>
            <begin position="198"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2174211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="470" mass="52007" checksum="FF07AE929738C04E" modified="2022-01-19" version="1">MSSRLLLSNAIKAHNGIANKFIRPLATATSLQPATRTTTLSNGLTVATEENPTAQTATVGVWIDAGSRAETAANNGAAHFLEHMAFKGTNSRTQRDLELQIENMGAHLNAYTSREQTVYYAKAFKNDVPQAVEILSDILQNSKLERSAIERERDVILREQEEVEKQLEEVVFDHLHATAFQDEPLGRTILGPKENIQSLSRDDLANYIKTNYSGDRMVLVGAGSVDHDFLVNLAEQNFGNLPCKSNQPVGSKDLTDKPRFTGSEIRLRDDTMPQAHIAMAVEGVSWTSPDYFPMLVLQSIIGSWDRTLGATGHMSSRLSAVVNKHQLANSFMSFNTSYKDTGLWGIYLISENKMQLDDLIHYTQKEWARLATTVTEGEVERSKMQLKASLLLGLDGSTAIAEDIGRQILTSSKRMSPQEVEAAVSNISVADVRRVASQYLWDKEVAVVGLGPIESLPDYNRVRGYMSSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PL73</accession>
    <name>A0A8H7PL73_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_001136</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PL73"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF112">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G02370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="88"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2175489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="305" mass="33591" checksum="FE3C359842D65266" modified="2022-01-19" version="1">MALCKQGNQNSKVYLLFAFCIYYNRFQDEQGKIHYGQPILSGEELKQSDVQKGLKAHIIEGDIWANCTVTAKTCTVKKLLSPVTPSVIRCIGLNYRRHAQETGSRLPVKPILFMKPATSACGPFDPIRVPTVAQDDKIDYEAELAVVIGKECRNVTKENALKYVAGYTICNDVSARNWQLGPNSGGQWNFSKGFDTFAPLGPMVVSSNVIKDPQTLRLGTKLDGRLLQDFTTSDMIFDVSTIVSFLSQGTTLLPGDVIITGTPHGVGYTRNPPVLLKHGNKCEIFIEGIGNIVNSVEYERGQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLJ1</accession>
    <name>A0A8H7PLJ1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_005359</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLJ1"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031010">
        <property type="term" value="C:ISWI-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17997">
        <property type="entry name" value="DEXHc_SMARCA1_SMARCA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000022">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase CHR11 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000002">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase CHR11 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000049">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044754">
        <property type="entry name" value="Isw1/2_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09110">
        <property type="entry name" value="HAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="189"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="487"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="17">
        <location>
            <begin position="840"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="121"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1013"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="806"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="894"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2176126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1044" mass="121944" checksum="BCB69BD52172BF29" modified="2022-01-19" version="1">MANPPVSNFAIKRRHRDLLQQFSSYTSSKLYRAYLTYTLSPQAESMDIDRPQSDSEDDVYMDKKERIKHQKQQFADKAKSLNESKDADRLKRYRYLLGQTELFAHFFNLKVEQDEELRKVMEENEDSSKRQDEDGSRRRRKTEKEEDEEILKDEDEEGSDLPTVFTESPKYVAGGTLRDYQVQGLNWMISLFENGINGILADEMGLGKTLQTISFLGYLKHFRDIPGPHLVVVPKSTLHNWEKEFAKWVPDFKAFVLHGSKEARNEIIKNRLLPMDFEVCITSYEMCLMEKSHFKKISWQYIIIDEAHRIKNENSMLSQIVRVFNSKNRLLITGTPLQNNLHELWALLNFLLPDVFSSSEDFDEWFEKQGGDQKKVVEQLHKVLRPFLLRRIKADVEKSLLPKKEINLYVGMSAMQRKWYQKLLEKDIDAVNGAGGLNKREGKTRLLNIVMQLRKCCNHPYLFDGAEPGPPYTTDQHIVDNSGKMIVLDKLLQRMKAQGSRVLLFSQMSRVLDILEDYCWWRGYEYCRIDGQTSQEDRIDAIDEYNKPDSSKFIFLLTTRAGGLGINLTTADVVVLFDSDWNPQVDLQAQDRAHRIGQTKQVYVFRFVTENAIEEKVLERAAQKLRLDQLVIQQGRMTQQQKGASKEELLTMIQHGAQDIFKDTDASSVKDDDIDAILRLGEEKTAELNKKYENVSIDDLKNFSSDSAYQWNGEDWSSKRKAGSGFAWLGPAKRERKANYAVDDYYKEALRTSSKTPSTKAPRPKRYNVEDFQFFPPRLQDLNEKDTLYLRKSLGYKVPPVAVEGDEEQEKAREEEQKKIDEAEQLTEEEEEVRRELYTKGYSNWSKKDFSNFINACARYGRNNIAAIAAEIEGKTTDEVKKYSKTFWSRYKEISDYERHIAKIEKGESELEKQAEIQEQLAEKINRHRLPLQQMKIHYTQPTKGKNYTEEEDRFLIVMLEKYGYGTENVYDKIRQEIKGSPLFRFDWFLKSRTSQEISRRCNTLISLIQKENAEEEEDVREEKKQKRGNSKASTPVPTKSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PM34</accession>
    <name>A0A8H7PM34_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_005666</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C65 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PM34"/>
    <dbReference type="OrthoDB" id="18915at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22749">
        <property type="entry name" value="Otubain_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.20:FF:000001">
        <property type="entry name" value="Ubiquitin thioesterase OTUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.60">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042468">
        <property type="entry name" value="Peptidase_C65_otubain_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931:SF15">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTUBAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931">
        <property type="entry name" value="UBIQUITIN THIOLESTERASE PROTEIN OTUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="8">
        <location>
            <begin position="78"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2176426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="268" mass="30625" checksum="0BF25CAAEE461730" modified="2022-01-19" version="1">MSSSTANEEPQLTDEQILAFEQKIKDEEAEKIPLVCQKEPISALEEEFKENKPFLDKVKVYVIHIAKAIRGRLANSNNQFRKCRGDGNCFFRAFSFAWFESLMQNPQLFSQAVEKMKSSSELLLNGGFQQLAFEDFYDVTLEQLQQIHTSDPDLLLVNFQTEEISNSIVMHMRFVASAYLKIHSAEYEPFLMVESISIDQFCAQEVEAFGRESDHLQIIALTKALDIPVNIIYLDGSSDEQAAVHEFWPDEAAKGNRTPLQLLYRPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PM51</accession>
    <name>A0A8H7PM51_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">GPI ethanolamine phosphate transferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_005469</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PM51"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051267">
        <property type="term" value="F:CP2 mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16024">
        <property type="entry name" value="GPI_EPT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037674">
        <property type="entry name" value="PIG-G_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039527">
        <property type="entry name" value="PIGG/GPI7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2176235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="419" mass="46516" checksum="4E9C1F384B4C9F1A" modified="2022-01-19" version="1" fragment="single">MVLKSLQSLLMLSALQLTALFLFCKGFFPYKTYLSGHATEADSPSRLDLTGIADDAPPQFDRLVFVLVDALRNDFVFEKSSGFSFVQSLISQGSAKPFTAKATAPTVTLPRIKALTTGTIPSFVDAILNIAESDTSSSLKYQDNWVYQLSNNGTNTINFFGDDTWMKLFPGLFSTTDGTTSFYVSDTVEVDKNVTRHVSPELERSDWKALIFHYLGLDHIGHLGGPESPLMLDKQKEMDNVIRTIYEAVAEEDHKRRKASHDVHGTLIVLCGDHGMNEAGNHGGSSESETSTAMVFMSPKYESRPTIKRKGTRQRQTFSKRDRYGYPLIEQIDIVPTLSTLLGFPIPKNNIGKVILELFNTNNAVPTLRALQLNAHQIAEVLTAHIGISYERKSSINDLDSPTLIKLELSEEVKSIQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMF0</accession>
    <name>A0A8H7PMF0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_007533</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMF0"/>
    <dbReference type="OrthoDB" id="689350at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000008">
        <property type="entry name" value="Copper transport protein ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2176879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="58" mass="6072" checksum="E2EFC4773E8B1EC9" modified="2022-01-19" version="1">MSCSGCSNAVNRALSKLEGVDKIDIDLEKQLVIVDTGLPQETVTQTIAKTGKAVTPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMJ9</accession>
    <name>A0A8H7PMJ9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHF complex subunit HOOK-interacting protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_005428</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FHIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMJ9"/>
    <dbReference type="OrthoDB" id="5350595at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019384">
        <property type="entry name" value="FHIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045669">
        <property type="entry name" value="FHIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045668">
        <property type="entry name" value="FHIP_KELAA_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705:SF11">
        <property type="entry name" value="FHIP FAMILY PROTEIN CG3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705">
        <property type="entry name" value="RAI16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19314">
        <property type="entry name" value="DUF5917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19311">
        <property type="entry name" value="KELAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10257">
        <property type="entry name" value="RAI16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHF complex subunit HOOK-interacting protein C-terminal" evidence="3">
        <location>
            <begin position="809"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="582"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="658"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="762"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="919"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="961"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="582"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="606"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="663"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="935"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2176194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1130" mass="127613" checksum="02056F0D8D432C46" modified="2022-01-19" version="1">MFLQKLLSGRNNLNKSKHELLMDAWTSVQRYYETASDPLKDAIELTPIPTCLQNIVKLIQSEEFDYQRANDNLATGPCLEYVLQSRVLEELVEFAKVDVNILDLIIFLNYYYARTPYGMRVHCLRFFTSLITNVHAQILPERAVHVPLQKIIQSCHRLISHHHEQLAQGLECSEERHNAIAELSLELVRLIHAVFAHFKGSNAALMDLFFERGWCRGLGEKVWRNNRNNSKSRHRRRESVDDKIAWNVFLMPRFDMFTYLLDYMNIPGETSEIAREAILFALRLLDGDPEYVCYVIEYSGLCEVMAERLALLFVSLPKTVGSFTISPTSRPVPVRPPQRRVHFAVPAVVASNSLAVAASAHHSFIKKRRKRSPFDADFVRSLDMMADGERIVDEFYSFWELLNDMARVGDKRLTTALIAQLTTTFWHPIICTALGSSFPDLAIATTKYTTEMIKSLTDQMLLQSFLVVLIGERGGVGKDLEPETPPRIVDDHEVSDQSADESTDKVTSTPSTAEEEITLRTLLIIRIHEEPELLSLCTLRLFDTILETYNQFAVYNLVLRNYLDITADGKYKDEEAMNTSKTIKENGEDKSVASHEQAKDQKFEDGSEEEEEGDGDDDDDTPLAKTSNAKQQNEKDGKVRWLVERILSLLPLEDELERMKSPPMSSVLSAEQNNSYMRPSQESTNEKSSSLNGDANSFVDSVHSSTSGTASLMVPGNSYDDYFVEAQERLQYGLLARNFWVAPYPPVKTWLDRDRELEDLRGRPKRKSMNLTQETLIEEEEPSDEQQRANGNIYSNKDEEQPPTAGHYEGLFLSTLFDEFAKILEASLERNLVITSILSKIVGIVDRRIEGVLCDWRAIRQGEDGAYYGGVWTLASGRGNRRSLYAMLEQITFEALRRAQVVPNFETRISIAKRRGLTTAQIPSAPPKMKESKSLLRSGSGILSGRKSDLTRRPSLSQLVFKGSSHSTDPVPPVPQPVPSMSTSVLQDKSKSSSSNTAMPPPLPTNASSSFFQQSQRANFTPVTMTNPFAKLSHFVNAYIVLQEFCKEVAAAALVLHSTTFAERELTPIQQVEWLEESEYVSSFEKARNRMSVLSVQDWRGVDDPDQEERSLEAMGLGGPVGGLVASNQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMZ0</accession>
    <name>A0A8H7PMZ0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="5 17">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">INT43_007545</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 17">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 17">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the ALAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="5 17"/>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMZ0"/>
    <dbReference type="OrthoDB" id="1530at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04824">
        <property type="entry name" value="eu_ALAD_PBGS_cysteine_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000048">
        <property type="entry name" value="Delta-aminolevulinic acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006762">
        <property type="entry name" value="PRK09283.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG2176891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="335" mass="36626" checksum="EA77E61ACC7A8FAE" modified="2022-01-19" version="1">MSDISSILHGGYHHPLTRTWQAEKTLTKSALMYPLFITDSPSQFEELETMPGQYRIGLEKLEGFIEPLYKKGLRSVILFGVPLADGAKDETGSNADDPNGPVILSVKLLREKFPKLFIACDVCLCEYTSHGHCGILREDGSLENQESVKRLATVALNYAKAGAHCVAPSDMMDGRIKAIKEALIENGLAHKVMLMSYAAKFSGAFYGPFRDAVNSAPSFGDRRCYQLPAGGRGLARRAIIRDMAEGADVIMVKPGMAYLDIVREAADLAGDHPIAVYQVSGEYAMLWHAAKAGTFDLKGIVLESMNSFLRAGAGIILTYYAPNLLDWIDEEAAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNV8</accession>
    <name>A0A8H7PNV8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNV8"/>
    <dbReference type="OrthoDB" id="2390325at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="136" mass="15591" checksum="4C515641D8F9FAD7" modified="2022-01-19" version="1">MTLTHLLLHDMIMLPRATMNDPRPSNEYIKQQARKENEYAQQYEDNKRRGSGSFDDLELDQAQTPDRVDQSNWSWREGGSQQYQEALADDSMLPDLPEETPRPKYDESNQLGLVDADLVNDSTTYSQPNESIAPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNZ7</accession>
    <name>A0A8H7PNZ7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_007568</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNZ7"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047173">
        <property type="entry name" value="STRAD_A/B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014:SF21">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="83"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="453"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2176914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="506" mass="56038" checksum="148FD5B71A90525D" modified="2022-01-19" version="1">MDSRHGRSASVSLAKSSKGFLVDTNKKAAITTKVTELVLHSKTNEDDTIMTIPTSPIAALPPLQRSISGRLFKSSLKRHGSVNDASAFLGESSFNTFGVSSVQRPGPRRRNASVSDMFNHFASSIGAKSASEPDLALPTRRYSAEMLDYEVDILIGYGATATVHLARYLPTNEQVAIKMVDMDMFAPRQIDELRSCHDILQAHSNGLEESVIRSILKQVLDGLYYLHCNNLIHRDVKAANLLVDRTTGNVKLADFGVSAVLTLPEAQPPSILLNGRSPGTRRRATRHSFVGTPCWMSPEILESKGYDCKVDMWSLGITALELAHGRPPNSYSDPANIFKSIVLSAPPSLDEDKCEHTYSDDFKDFIKSCLVKDPNERISSASALNHPFFRKAFAPPIIVQYLRDTCYERRRRRYNNTTTSAPPSGDETFGAWDFPPVIDTSIPKICINEPESDVPELFDSPSESPITPADDPPPYALYGQSHSVNTKVRSERFASPYHSFVYDRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PP87</accession>
    <name>A0A8H7PP87_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">INT43_007972</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4251012at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00828">
        <property type="entry name" value="elong_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03447">
        <property type="entry name" value="FAS_MaoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08950">
        <property type="entry name" value="KR_fFAS_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.20:FF:000005">
        <property type="entry name" value="Fatty acid synthase alpha subunit FasA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000078">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000006">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2490:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.25.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3330:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000003">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="FAS1-like_DH_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041099">
        <property type="entry name" value="FAS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047224">
        <property type="entry name" value="FAS_alpha_su_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="FAS1_DH_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18325">
        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17828">
        <property type="entry name" value="FAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="19">
        <location>
            <begin position="2233"/>
            <end position="2309"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="20">
        <location>
            <begin position="3192"/>
            <end position="3729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG2177315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="3961" mass="437449" checksum="4F295ADFFA635E90" modified="2022-01-19" version="1">MESQLLRPLSIKQSKTEVSFLIPTNIWVAAEQLKEEFHLEETEEDEPAEIEVAAQFLRFAVQRSSKEQPFIPVAAHLFTSFCNRYLKKNDVHAVTRSLATESRKVVLNAYYSGLFQLKDSLDMKEISSPESALFAAAARGETKIFAMFGGQGNIEEYFDEMADIYETYDGLVKPYIESMAAVLSEHARSSEASVLHSKGLDVLKWLESPESRPDLQYLISAPVSFPLIGLTQLLHYYVMLRVLQRTPDEVRKYIVGSTGHSQGVIASVVISSSATEEEFIANSAKALGLLFWMGTRAQQVFPSTTLNPTVLEDSLSNNEGTPTPMLAINNLREDQVLKHLEATNSHLAPDRQIKLTLNNGPRSFVCTGPPQSLYGLNLSLRKLKAPTGLEQSRIPFSQRKIKFSSRFLPITAPFHSSYLEQVAPILTKDIERCNLQFSANNLVIPVRATDTGKLGLGLWGLTTKKKLNAGRQIVFGAHYCDDLRKSSDLTKDLIDLICSRPVIWEQALNVPDLTHIIDFGPGGTSGIGGLTHRNKEGTGVQIILAGAAEGNNKELSYKADLFDADIKAVKYSQNWAKLFQPKLVRTSSNGRIHVDTAMSRLLGKAPLMVAGMTPSTVSEKFVSAVMNAGYHVELAGGGHYNEKALRSKVDKIMNLTHPGEGITLNILFLNVRQWGFQYPLVQVMRQEGLPMEGVCVAAGVPSLDVANEILQNLQAAGIRHVSFKPGSVETIRHVISIAAANPTMPVIMQWTGGRAGGHHSFEDMHQPILETYAAIRRQANIVLVGGSGFGGAEDTLPYITGDWALKFNYPPMPFDGILFGSRMMVSKEGLASPDVKQAIVDAAGVGDGDWEKTYSGPAGGVITVRSELGEPIHKIATRGVRLWKEFDETIFNLPKDKRLPIIQNKKDYIIKRLNADFQKVWFGKKADGSVADLQDMTYSEVVNRLVDLVYVKHETRWIDFTLRNLVGDFLRRIEERFSKSEKASSLQNYSQLEVPQDFVPDFLAQYPEAETQLLTSEDVLHFVALCQRRGQKPVPFIPVLDKDFDVWFKKDSLWQAEDLAAVVDQDVQRTCILQGPLAAKYATRADQPVGEILGEIYESHIASLKERYYNNDDKLIPEIEYLGGNKIVNKGLIQGQESGDAQVFTTGDSESKLPSAEAWFETIAGPNYNWLRALLTSPFIVQEKKFIDNPMMGLLRPRVGQQVSVKKSNGKIVSLTVQDKRPWSATGQTDDLVPSVEISAESNNIKVVIFEKRGDDLIPFPMLFNYKPETGYAPIHEVMEGRNDRIKEFYYKLWFGVDANEDFLNIPVHEKLIGTGETVQASIIKDFCQAVGNEAEIYVDRGQVLSAPMDFAIVVGWKAIIKAIFPKVIDGDLLKLVHLSNGFRVVDGAELLKQGDVVDTYAQINAILNTESGKMIEVKGVIVRDNKPVLEVTSQFLYRGQFKDYEHTFKRTVETPMQLTLNAVKDIAVLRSKEWIEWNEELDNYELSPGATLIFRLNSENYFKDRTVYSKVRTTGTVSMQISTKEIVEVGSVQYEAGESHGNPVIEYLKRNAQPIEQASEFENGGYSVMPAESVYSSVVHAPASNEPYATVSGDYNPIHVNPYFADLAKLPGTITHGMWTSASTRKFVEIFAADNVPQRVVAYDVKFVGMVLPSDRLETKLSHTGMKNGRKIIKVETINQNGEKVVEGTAEVDQPTTAYVFTGQGSQEQGMGMALYDSSPVAKDIWDRADRHFMTNYGFSILEIVRHNPKEKIVHFGGPKGNAIRQNYMSMTYDVVEQDGSTKTLPLFPNINERTTSYTFRSPNGLLSATQFTQPALTLMEKAGFEDMRAKELIQTNCTFAGHSLGEYSALASMGDVLPIESLVDVVFYRGMTMQSAVKRDESGRSNYGMAAVNPARVAKSFNDTALRYVVDAIAVQSKDVLEIVNFNVENWQYVAAGSIPNLDVLTNVLNYLKVSKIDLQKLMETMPLEDVKKQLSEIIDGALEKARAKIAASGRIQLERGHATVPLPGIDVPFHSSFLLSGVAPFRTYLAKKINPTYVDVNQLTGKYIPNLTAEPFSIAKSYIENVYNLTSSPRLGKVLKTWSDDKFATAGQQQRLAYTLLVELLAYQFASPVRWIETQDQLFKNFKVERLIELGPSPTLCGMAARTLSLKYQAYDDALINRRANLCFSKDAKEIYYMFENATEEEAAPTDGASAPAATSAAPAAAAAAAPVAAPAPGAGPAAPVSDAPVTATEVIHVVIAQKLKKSVDEVPLSKAIKDLVGGKSTLQNEILGDLQKEFNNTVPEKAEETPLDELGAALNGSFSGSLGKHSSSLVAKMISSKMPGGFTLNSAKTYLGTTYGLGSGRTEGALLMGLTMEPAARLGAEPDAKAWLDTVAQAYAKKAGISLSTGGAGGAAGGAGGAAVAVINSEEFDALKAKQASLVYQQLNIYARYLNRDLREGDKKYDEEKKVTAKLQAELDLWLVEHGDFYAEGIKPSFSPEKARRYDSYWNWVRQDALEMWYDIIFGELAIVDREVTAKCLHIMNRAHPALLDYMRYNVEKCAANKGETYRLAKEFGQALIENCAEVLSLSPVYKDVTFPTGPKTTLSDKGDVKYEEIARPGCRKLADYVKDMATGSKISEYSNRQKVQQNLGRIYKIIRSQHKMKKSSKVAVKDLYADVLRSMNMSNTIIKETKGRQRRLSSSGRPAEHKKLAAKAAKSETIPFLHLKKKNPNDPSGWEFSSRLTTTYLDVLGEIAEEGVTFVEKCVLLTGAGKDSIGAEILKGLLSGGAKVVVTTSRFSREVTEYFQGIYQLHGSKDSQLIVVPFNQGSKQDVDAVVDYIYDPKGLGWDLDFVIPFAALSENGRQIDNLDSRSEFAHRMMLTNLIRLLGNVKSHKQAIGSDTRPAQVILPLSPNHGTFGSDGLYSESKISLETLFNRWYSEDWSGYLVIAGAVIGWTRGTGLMSPNNQIAEGIEQLGVRTFSSVEMSFNILGLMHPDIVDLCQNEPVWADLNGGLHFIPNLQEISNNLRQEIRETAEVRKAIDADNSLDFKVTFGDEAERKHKPHKITPRANMKFEFPKLQAYENLKHLGHLKGMLDLDKVVVVTGFGEVSPWGNSRTRWEMEAYGQFSLEGCIEMAWIMGYIKHFNGNLKNGTPYAGWVDAKTNEPVEDKDVKSKYEKQILDHSGIRLIEPVMMNNYNPEHKTMLQEIVVDHDLEPFECSKEEASHFKQEHGDKADTYETETGSWIVMLRKGANLYIPKALQFDRLVAGLLPTGWDAARYGVPKDIIDQVDPVTLFNLVSTVEALVASGITDPYEFYQYVHVSEVGNVTGSGVGGGIAQRGLFRDRFLDQPVQKDILQESFINTMPAWVNLLLLSSSGPMKTPVNACATAAVSVEMAVDSIVSGKAKIMIAGATEDVTEESSYEFANMKATSNAVDEFAKGRTPREMSRPATSTRNGFMESHGAANHILMSATQAIEIGAPIYGIVALTNTASDKEGRSIPAPGAGILTTAREKTGSVKNPLLDFKYRARQVKSRRAQIKLWVESEFDALREELEELKASGELQVSEDEWLNERADFLHKEAKRQEKEALGTWNMNFWQSNSDIASLRGALAVYGLTVDDINVASFHGTSTKANDKNESRVINNQLTHLGRSKGNALLSVFQKYLTGHPKGPAAAWMTNGMLQIINSGLVPGNRNADNIDEVMREFEHIVYPSKSIQTDGIKAGLLKSFGFGQAGGEMLLIHPSYVLASLEEHEYTAYVAKNAQRQAKSYRYLHDSITGVCDFVQVKNEPPYSAELEYQVYLNPNARATYNKEKKSWAFDKKSTATALVNSNDIAATKNILESLAQKQAGNKGVGVDVELTSSVNTHNSTFVERNFTSSEIEYCNSRPDPQASFAGRWSAKEAVFKALSSYGDVQSKGAAAPLIDIEIGASQDGAPIVNLSGVAKEAATAAGVNDVKVSISHSGAYSVAVAFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPG5</accession>
    <name>A0A8H7PPG5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Arsenical-resistance protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_003000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPG5"/>
    <dbReference type="OrthoDB" id="187348at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015104">
        <property type="term" value="F:antimonite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000009">
        <property type="entry name" value="Arsenite transporter, ACR3 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057:SF1">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="ARSENITE EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0059">Arsenical resistance</keyword>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2177753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="44331" checksum="728CDD40981723A9" modified="2022-01-19" version="1">MSDPSIRERCIKSAECNFDYCIERSTADSISVVQDEIKPSDLLHKLSFLDRFLVIWIALAMVIGVLIGYYVPGVQPAFATVQFSSVSVPIALGLLIMMYPVLCKLQYEELPRIFSQREIWIQIALSLFLNWVIGPILMTGLAWATLYDLEGYRTGVIMVGMARCIAMVLIWNHIAEGNANYCAILMVVNSVLQIALYSPLCVLFVNIVPTWFGGHVDAAVALEMWPVVQSVLIYLGIPLAAGFLTRVILVRLTSNQWYETKFLPHIGPFALIGLLYTIIVMFANQGHHIIDNIGSVFRVMVPMLCYFIVMFFGTFMICRLLGFPYAQAVTQAFTAGSNNFELAIAVAVGVYGINSDQALAATIGPLIEVPVLLVLSYFSLWMKKKLQWRKIETTEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPQ6</accession>
    <name>A0A8H7PPQ6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_003240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPQ6"/>
    <dbReference type="OrthoDB" id="276721at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF16">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2177987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="30864" checksum="0929CE6F115B6D79" modified="2022-01-19" version="1" fragment="single">YLAYDDYTGLNVCKHAAWRGWEVVSLSRRGLPTGSTSGTDAEWKSQVQWVAGDSTDSESYKEIMDGVTDVVHTVGMLMENDYKKVVQAKSLGEAVSGAGAVLGQMLGMKDNGNPFKQDPRSKVTYETMNRDTAISLAKVAAQVPTIQSYVYVSATDLFPCINPRYITTKREAERYLFSRDEFRSVVLRPGFMYSENRPATLPLAGILQTLNTVSKPCSRDIASLPLGTMVTTPALNIDTVAEAVIESIARTSLKGILDPNDIEKLLASPPIGDFKAASPEPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPT3</accession>
    <name>A0A8H7PPT3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="2">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_003452</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPT3"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000021">
        <property type="entry name" value="Acetyl-CoA carboxylase carboxyltransferase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000030">
        <property type="entry name" value="Acetyl-CoA carboxylase carboxyltransferase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF46">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="6">
        <location>
            <begin position="32"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="7">
        <location>
            <begin position="291"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2178199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="546" mass="59594" checksum="825EB18D42DDB055" modified="2022-01-19" version="1">MSADTLQHHLVQPYKSVVSKTSEEYKRNYEEWQPIVEELHERLEEATAEGKEKHIKLHKKRGQLLARERVDLLLDEDSPFLELCQLAGYGQEDMTLGGSVVGGIGLVCGVECMVIASVPTLAGGSMNEASVLKGGRLGQIIYENRLPVINLQQSGGANLEQQFKVFHRGGGGFRHQAILSKSAIPSCCVVFGSSTAGGAYTPGMSDCVIMVKKQAQVFLGGPPLVQMATGEVTDAESLGGADMHSRISGVSDQLAVDELDAIRKAREWVSHLNWEKKGKLPLRHLQASFEEPLYPADEILGVASANIRIPFDAMEVIARIVDGSRFSAFKPLYGVNLITGWAFIHGVPVGIIANNNVLFTAESNKATQFIQLCNMKNTPLLFLQNITGFMVGKRYEEDGIIKAGARFINAVSNSTVPAITIMMGASYGAGNYAMCGRSYNPRFLFSWPNSKCSVMGAEQLTGVLDLIMRQAAKRAGIDIDEETASGRKQMFQSLVESESDVYYTSARMLDDGIIDPRDTRTVLGFCLSVIYNEEVKGGNLYGVSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQ35</accession>
    <name>A0A8H7PQ35_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQ35"/>
    <dbReference type="OrthoDB" id="2387694at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="88" mass="9475" checksum="73D82AE7436BBF28" modified="2022-01-19" version="1">MDIQNGPPSNYHQPPFESKSAQPAKENTEQQQNLASHGTATAVVDHGVQQSDSAKASQSKPENVEEGLNKADDMVEGYMDKKMGGANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PR39</accession>
    <name>A0A8H7PR39_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PR39"/>
    <dbReference type="OrthoDB" id="2448307at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF1">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="409" mass="46515" checksum="148FE46EF40ABD71" modified="2022-01-19" version="1">MARSAAYTPLSSGMSKFLNTTPIFKTRESTLTFGLIVLECVLICFLEGFVVQNHLALVSNCTLTTTASGISISDLIYHGLFIVSQVFQIVLCVDALYQRNTAQLIALVLYGLLVVGKRRVTFMHAYGGIQLQQHIILEQVGCGDINLWNPIDPRWSRDAAGQQEAISFYEHKMRPLEYTIIALIPCFFVIIAFFAWKLRKNFAWDNYRNFSADVRVRKALIHLSILLTLLKLDFYFIFSYAAQLIPSTRLNYDATNVEMGLVFTFGALGLALGFLAIYRENKWLMGTFLVCGTLSFIYFIYRLAKVAQPRPYNADPYEFTRHFLIFTILITALLNLATVAMTAVTFNNLWKGVKVFTKDRKGGLVNKNTPIDIDDDPDLEMHHHSHGGDKTEIEDSHRNVKNDDMWTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PR99</accession>
    <name>A0A8H7PR99_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_001858</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PR99"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057305">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24541">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034688371" description="protein disulfide-isomerase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="7"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="259"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2179009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="445" mass="49275" checksum="C7C321B0D808EED1" modified="2022-01-19" version="1">MRISLLTIFGATLLATSAQALYDKNGPVLELTAQNFKEEVMNDGHLVAVEFYAPWCGHCQRSLYYDRLAPAWKKAAGNLKGLVKVGAVDCDQDSNKPLCSQYGIQGFPTIKLFAPSSDPSKKATKRPTDYQGPREAKPIVDHLLALQPSNVRFVKGDASQVKSKKSISLNDFLDTDNSTLPKALLFTDKPTTTPLYKALSVDFADRMLFGEVKKSVKEAVESFGISKYPTLVVLTPDSGAIEYSGKLKKDALEDFLKQHALPAPEQSKKKNKSKAKKDESKSQKDDPTSESNSASFDPKVANLMTDKDLEDQCLSKSGICVIAILPAVDAEDERSSKEQADALHILEEVKRLDNEKNGNLSPFLFQWADANVGKSIITKFEMSQDYPTLVVVKPTKQVYRPFVGAWNENSIKTWLDIVAAGRFAVWDYKGDIRLSPVEKSPRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRL1</accession>
    <name>A0A8H7PRL1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">60S ribosomal protein L7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_001831</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRL1"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="5">
        <location>
            <begin position="29"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="4">
        <location>
            <begin position="105"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2178982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="30077" checksum="0861271EB1D20C97" modified="2022-01-19" version="1">MCTTVYIDYVSYVLLSSNSTVPTAEQVLVPETLLKKRKSNEKAAAEAATKKAELKKAQRAKRQVIFKRADQYVREYRAKEADEIRLRRQAKSNGNFYVPAQPKLVFVVRIKGINHIAPKPRKVLQLLRLLQINNGVFLRLTHATAQMLQLVEPYVAYGTPNLKTVRELVYKRGYGKVNKQRIPLHDNAVIEKSLGHLGLICIEDLIHEIFTVGPNFKAANNFLWPIKLSNPTGGFKSRKFLHFIEGGDTGNREHFINKLVARMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRL4</accession>
    <name>A0A8H7PRL4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">triacylglycerol lipase</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">INT43_003487</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRL4"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="20">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="436"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG2178234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="476" mass="53429" checksum="07BBFA5629B422B1" modified="2022-01-19" version="1">MYKKFWKSSKLLRMKLPRPVYHLFNAMPVNITLLNLTISVFCILSCLAGGLAQQQMAFTAPEFGKSLTFKHIYHLASYSGKYPGMFRRMDFTEEQAMVKADFMEKQLRFDVKQTIGRQYRPGSPLPHLMKAAQTPRQMHYAMGIHNMKLDYGLLPDVKDRQTVLALAQMTNNAYSDPDTREDWYDLGTKWNVTKSFGWKSDGLRGHVFGDADNTTFVISFKGTSAGLWTGGPTGDKDKLNVSMPYIQESPIICFFLVAALVLVVRGEQCATVTLKMYIEVADQYPDATIWLTGHSLGGAIASLVGQTFGVPTITYEIPAERLASRRLHLPAPPAVNWKETPLWHFGHTADPLFVGVCTGPSSSCWYGGFAMETRCHSGNVCVWDTVNDNGWRIDIRSHRIIDVIENILKKPEEFPLPDCHPELECTDCGLWDYPDDRDPPNTSSGTCSSTKGPEIPDPTDDPWKTTTDNPVFASHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRW6</accession>
    <name>A0A8H7PRW6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRW6"/>
    <dbReference type="OrthoDB" id="2142503at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="145" mass="16200" checksum="AAAF797FDA9E38C1" modified="2022-01-19" version="1" fragment="single">LSVQAANPVFFCKCYCGANSTVFPLPIEDPKPCALCTKQMCIDSVTDGTCDGIIDSTCPSVDFKSLCFARDSYKDEAIVWSFLILTFSLIIVASVQPRVEKWWKVRVILISLFEVAIQSKPCHPNYVIYRTGINILRSQTIHTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PS66</accession>
    <name>A0A8H7PS66_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_001961</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PS66"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2179111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="49618" checksum="E8D003055FD3573C" modified="2022-01-19" version="1">MKLHQQYGHVVRISPKKLLISDKDMITQILAKDDMPKADLYLSFQMDNNPTMHDTIDKAFHKTRRRVVSPAFAIRYLATMEPLMHEKMQIMVDKVTKTIELANANGTKYAEMDLWKLLQHLTLDIIGSTAFGTDFNMIKTGSHPLPDRINSRLKYSSFLIMFPMISRHIPKHMDPYLVSFMTKVIEERITSGKRRQDILQILIDTQKAESVEDRLAIAEMINEVIIYLVAGSETSSNTIGFTIVELLKHPEAMAKLRQEIDDLEFEDEKTLFQHSQLKALPYLNAVISETMRLYPVATAGLQRKTYTDITLAGKLAVPENTTFVCNMFASQTHPDYWHVADKFLPERWLDSAYPEPTLDAYYPFSAGSRGCIGKNFAYQEMRLCIATIFKYFDIKPISLSMEKVKDTRQYVTLTIRGNSFNVHISKRETKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTA6</accession>
    <name>A0A8H7PTA6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RPA43 OB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_001984</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTA6"/>
    <dbReference type="OrthoDB" id="10250504at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPA43 OB" evidence="6">
        <location>
            <begin position="121"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2179134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="275" mass="30884" checksum="AEC1F07B8F9552AD" modified="2022-01-19" version="1">MAPHTHTHKEAKKRKHADHEDHSASKKSRLTVEKSIAVPDMTAFSEVSVRLYLHLAPTWAGKTTEGINEQLNAFLMKYIPEVDGIVVAHSGLRFETANGRIMYDSPFSHFFIRVKLLVWKPNKGEKLVGKINLQSPDHIGLLIYGTFNASIPREHISQAHYEWRASTQEDQAEEESDEADEADQEQPYEYKKNEFGEWIDKESGQGVADNNGVIEFNVVNLVSANDILTVTGALLAPSAKDNTTSLALDDTSAPKLQEKSKKDKKEKKKSKKEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTJ6</accession>
    <name>A0A8H7PTJ6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003632</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTJ6"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00302">
        <property type="entry name" value="cytochrome_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2179846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="56231" checksum="05C03D00D630877C" modified="2022-01-19" version="1">MLDTKTAVSATALAVAAPVAALLAYLLSFDLTTRQKLKGLNLPTPDIKSAFFIGQFREESFFYQMKTIFESIRSTYKVHTPIGPMVVTDDPEDFKKVFLQTNLEKGGANHEVRRYWGTNNLVTLPHGGEKGQIWKTQRTLLDQGFRIRALKVLQSTFVRHTEKFVANLETLVDQEVDMTSLFADFTFDIITDVIGAGGEAPREFKDNMNFLIRRLENPALLLPYGGYLMRYIMFRRANIIVDKFLYKIIRERKAARSHESFNEDKEHKTILDFLLEAEDDNGRKLTDHEIRDQLYVFFLAGFETSSNTLGWMAYELASHKECEQKLIDEVKSVDGPLDYDSARKLEYVQHCINECLRLYPPASNLTRETEQDFILPSRPDVIIPKGVQVTIFLFGMHRDPKYWDQAEEFVPERWSEPQQTPGAFGPFSSGSRVCIGRNFALAEIATLIHGIYNKYRFELKENVEKNGEIDGRTGLLRPYKVVGYLRKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTX3</accession>
    <name>A0A8H7PTX3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTX3"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01518">
        <property type="entry name" value="RHOD_YceA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022111">
        <property type="entry name" value="Rhodanese_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020936">
        <property type="entry name" value="TrhO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040503">
        <property type="entry name" value="TRHO_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43268">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE/RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43268:SF6">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12368">
        <property type="entry name" value="Rhodanese_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17773">
        <property type="entry name" value="UPF0176_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="231"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="420" mass="47737" checksum="9A8B97FC3CD7215B" modified="2022-01-19" version="1">MPVDRILDRARRRAATLYLERCSKVDGHWSCCDSTFLTKGDAFKHAYSVHEAKLLQEQDKLYQEFLQAGKQEDSNTPSIFEKRRAKKGDSDSIATDCTCNVQESTVILFYVYQVIADPKEIAEQHYRLCSDLYMTGKVRVGEEGINVTLAGSNDAISQYIKYVTNALDLSDKDYYDFFKPSPGCVHVFDDLSVKLVKEICPLNVDVTLDKLMTATHKAGKIPPAQFHDMLQRNDVLILDTRNYYESRIGKFDGAITPPTRKFATFPAWVDRNKGALDGKTVLTYCTGGIRCEKASAYLRQKLSSSTQVWMLDGGIHNYLEWTKQSDVAPLWKGKNYVFDARQSLGDDVNIISTCQLCQQPCTRYIKCTRQCHKLVICCRECEHKHEEIVCCNSCNGLSGWCQCEVERRELEKTPISPICP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUH4</accession>
    <name>A0A8H7PUH4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Xenotropic and polytropic retrovirus receptor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_003757</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYG1 (TC 2.A.94) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUH4"/>
    <dbReference type="OrthoDB" id="9970435at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14475">
        <property type="entry name" value="SPX_SYG1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="556"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="655"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="681"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="9">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="8">
        <location>
            <begin position="550"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="739"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="753"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="765"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="785"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="822"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2179970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="839" mass="98259" checksum="D33075AC819D4108" modified="2022-01-19" version="1">MKFAKYLESESIPEWRKAYIDYKGLKKKLKVIEKYKKGRTKRFSIAPNLSDEENTTNDNANQSNRMASDQAANKTMMHRSRTEPFLPSEFKNRSFTSGFWERLSWTSRKDIGLNQFESRPASIQSRQGSVLDDVLEHATPPEREFFEALDAELEKITNFHYEKKHEADSKLAALKKQVMLIEEYGKHLVQIGPTDPYEHPKLSQFVIWMRRRVPDLSEDANAMETGDPNLPRMSPSKDEDHHNHHISYKVARSRLKKALFEFYRSLEFLRSYRALNATGFAKILKKFDKTAGWNATNLYTRKLQEYNWYRSDDLQALIDETEELYVNEFAGGHRRRGMRKLRIPEATRDYHSPVLRTGLYLGLIIPAFVRSCEIALDKSSLLRLPNLYTNLQIYACFVLPLIFSLGFAVNMMVWSKSRINYKFIFEFDPRDNLNYHQFAELPALLLLIMTYVMYVDFTEAFAPAIPSEICPLIFVVILIAIMFCPFNILYLSARKWLGIALGRILLSFCFRVEFRDFFIADELNSLSYSFWTLSYFFCAYGWHWSNLEQHCQVTKFWITPIIACLPAWWRLLQCIRRYKDSREYVHLVNAGKYLTSIWATALTGTRRIHNFPQMQAAWLAASIINSTYTALWDLKMDWGLLQVHSRYFLLRNDLVFYHWTYYVAMPVNVALRFAWIVNTVGLPLGGEVLGFIFGFLECYRRFQWNFFRLENEHLNNCGQFRAIKEIPLPFSVMEEVPSRRGSQIQLPAAEDETYPRTEDTRPVGRSNTLKNLVSRPDSTSGTFYGRRDFEAKQDSDNDDQNKPSGDSMFRRITRITSRAEESDSEEDDDDEDGARQHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVC2</accession>
    <name>A0A8H7PVC2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008559</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVC2"/>
    <dbReference type="OrthoDB" id="5512at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00581">
        <property type="entry name" value="CLATHRIN_LIGHT_CHN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="30"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="165"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2180977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="236" mass="26407" checksum="E644837607D82AF5" modified="2022-01-19" version="1">MSDFGDFNSSMEDPTADFLARERVALGDDADLFANDSPSLSSPAPQQVPLPSVTPTEQLENRAFSPSSQNAFSPQAAHGFGAISPAPAGDYSAFESEFPAAEELETSQAFINASTMPDVEPEVVKQWREKQKELIAERDAESEEKKHEIIQKAREAIDQFYEDYNDKKQKAIEQNREKEENEQSERDQAASGTVWDRITREIDPKTNTNTRDVSRMKQLMMDLKKDSRAPGTIVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVT6</accession>
    <name>A0A8H7PVT6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_008740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVT6"/>
    <dbReference type="OrthoDB" id="5571754at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3370:FF:000001">
        <property type="entry name" value="40S ribosomal protein S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_eS24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2181158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="130" mass="14866" checksum="F5EAF35B22E27584" modified="2022-01-19" version="1" fragment="single">ADSVTIRTRKFLTNRLLQRKQMVVDVIHPGRANVPKDELREKIAKMYKAEKDVVFCFGYKTQFGGGKTTGFALIYDSLESAKKFEPKYRLVRHGLADGSRTARKQRKERKNRAKKYRGTKKAKASGSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PW06</accession>
    <name>A0A8H7PW06_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_008490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PW06"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF56">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2180910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="389" mass="42981" checksum="E760ECC7201CD674" modified="2022-01-19" version="1">MVQPLIIDCDPGIDDVLALILAFKSPEVDVRAVTLTHGNTTLKHVKRNAVTLMDVMAAQHIEDEKNGMKSQKQSTVLAVGRATPLNSDQVFATEFHGHDGLGNIYEQGLHTAPTDWENQLLHDAEKVGEQNKPFQSTSRDAADEILHQLRVADPLSVSILAIGPLTNLALAMQRDVQTFSRAKDIIILGGSLTAGNITPYGEFNFVADPVAADLVMTASKGFVNTEQGAKSRFDLLSQGKSAPMHIVVLPIDSAECGAIPASVYRKQILPLRGSAPLYTFINSFLLHAFKAMEELFKFDYMATYDAFAMILLLDMLNGTLEKNWCWKWHDMRVETAGKYTMGMSCIDTRDWESPDGSWNDQSNVVQVITKASGDNFIQSFMKRIFNVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWR0</accession>
    <name>A0A8H7PWR0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_008883</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Putative oxidoreductase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWR0"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2181300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="32928" checksum="AE2A90E8F08A4C03" modified="2022-01-19" version="1">MLGYLAIGALTAATAYYWQERHAQRPQQLKPSDERVVIVGCTSGIGRETALLYARRHAKLMLFARRQELLESLKKETEALGAQAHFVCGDATSAEDVKKLSQSTIDNLQGVDTLIICAGAISVQPFLDLCGGVDGQAKRDPMDAVRRITEINYYAPIQLTQAFLPKLIQSSEYPNIMVVSSLAGKTGAPTRSLYAGSKHAVHGFFDSLRVEVTKYNVHIGIICPGTVDTDLRQSAVDLDSSSAVTGSTKGKLSPKTVAQVIIEASDRRQREVLLPYLMGLGAIWGKLLAPGIVDRFASKKYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWS7</accession>
    <name>A0A8H7PWS7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWS7"/>
    <dbReference type="OrthoDB" id="2258182at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="2">
        <location>
            <begin position="281"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2181258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="341" mass="39011" checksum="16B8014A445016B7" modified="2022-01-19" version="1">MKISSLLAGPTLSPSPCSCISVHDLATVYKERLHKSGFNVVADLNPMKNASITFDISTSKLPKTTMYIKTASYNKLGKAYRCQFSSGKSRLPIKSSQLGSQMKMVNIFFNSSDQDQTILPQFLLFPSWLLHAFQFSKHGKNPGRTELRFFLDASDAKLDAVFRFNNILNILFRFDIDNIDRNQIENVIRLSNHLAKMCSNRPLSPPPSRAPAGVHQLYADMIELLNQQRPNKMKPACANCLNKPSSRRSLCVACYRYQLKYNVPRPRNLISNRRTCKKISLPPKKQCVNCSVNTTHQWYRNTLGKGHWCETCRSYFVRNKALRPKKLFVKAAQRNLNLHTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXW0</accession>
    <name>A0A8H7PXW0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_007312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXW0"/>
    <dbReference type="OrthoDB" id="4953at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF16">
        <property type="entry name" value="METALLOPROTEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2182382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="133" mass="14642" checksum="A001D6733A6FD976" modified="2022-01-19" version="1">MQHDCINGSPPHVPGRLWMSTYIRAVSNHTPSNINHHDVTLITGWLDYSLVFLGSEKYPFKGVLDSLANRALAQGTNAWTDVDHTCYTITTAGSEGFLNILPVYIDHILYPTLTSSGCYTEVHHINGKGEDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PY92</accession>
    <name>A0A8H7PY92_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PY92"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF115">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2182336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="274" mass="29725" checksum="9F621CA3E9DF6BAE" modified="2022-01-19" version="1">MTATHPDRTFNVSDALKLTGKVCVEKFSVTGASSGMGYEIVRGFAQSSAKAIAMIDINDDLGAKVHQELQAEFPDLKFKYYHLNISEYEEVQKVYAGIVEDFGEINVQVSCAGIAGYTPAVEHTPETWHKVLNVNLHGTFWTAQAAGRQMIKQNKGGSIIIIGSISAHVVNRPDFQPGLSNYCISKGACVQMAKVLGIEWAEHNVRVNSLSPGNMKTPLAPTDEKSINFFNHYTPLGRMGAAWEVAGAAVYLASDASSFQTSSDILVDGGLVHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYE3</accession>
    <name>A0A8H7PYE3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYE3"/>
    <dbReference type="OrthoDB" id="5586934at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2182200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="257" mass="29164" checksum="814C4E3F763D5DEA" modified="2022-01-19" version="1">MTNLDIKLKAANTIATIVLVGSHGFSFQDWFLRHPTEFGGRDFILILSVILEFLLIGMTVYQWLPSAPKDTFEAIGYWYLIIALVNSGQALLWYFHLNILAFIGLLWLVAAIFFVYHRLRDFPPRNAVDAIFVNAPFSIYAAFTLFAVLFQAFWFSKITRTHPVVHTVIIIVIGFVALHLVDYSHRKDWVYAATTSWIMLAAAVFLAGVPHVTALVVCGILISAIARATIPDMLERINRRFSRMTDRFSGERAPLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYF5</accession>
    <name>A0A8H7PYF5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial fission 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_007356</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in mitochondrial fission.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the FIS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYF5"/>
    <dbReference type="OrthoDB" id="421154at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12212">
        <property type="entry name" value="Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033745">
        <property type="entry name" value="Fis1_cytosol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028058">
        <property type="entry name" value="Fis1_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14852">
        <property type="entry name" value="Fis1_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008835">
        <property type="entry name" value="TPR_repeat_11_Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2182426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="175" mass="19795" checksum="12C4B0434FECD1BC" modified="2022-01-19" version="1">MATDSIPFASEAETPLPAESLEVLRKQYVREGEYATIQTKFNYAWGLIKSKRSMDIENGVRLLTGMWVSRNITEQDTIELNELLPIEIYQSAPERRRECLYYLALGHYKMSNFIEAKKFNQQLLMHEPKNSQAIELNKLIDEKVSREGVIGLAIVGSIAAVGAMVVASLVRKTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYN3</accession>
    <name>A0A8H7PYN3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tctex-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_007145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYN3"/>
    <dbReference type="OrthoDB" id="10059120at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21455">
        <property type="entry name" value="DLC-like_DYNLT1_DYNLT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF4">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2182218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18415" checksum="1F0DB532C5EAFADD" modified="2022-01-19" version="1">MENTAVSPSLSDGPLTPAAEVRELHGWGRNETMDNHKKFNAEEVTSIIKETIEATITDTVYSHTKVPEWNSAIVDTCLKRLKDMNRNFKYVANHTMFKIQNLPASLKYLTHKHSPVTCVIMQKNGAGFYAGSSVYWDNSHDGSANYRFENKSLYAIVNVFGLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZR3</accession>
    <name>A0A8H7PZR3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZR3"/>
    <dbReference type="OrthoDB" id="2011998at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008486">
        <property type="term" value="F:diphosphoinositol-polyphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901911">
        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901909">
        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901907">
        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071543">
        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2182404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="143" mass="16121" checksum="B6FF89CC7FAEEA1F" modified="2022-01-19" version="1" fragment="single">FSCLSNSIFGYFQSAGILAVNPKTRMVLLLASRKREGAWVLPKGPCMTEPQPEAPESAACRIAWETCGIRGTINKKVGTFTEAGKRGKINAYNWMYEMQVDKLEDNWPDHDRQRIWVSYEDALRATADRPISLLALKHCSLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q095</accession>
    <name>A0A8H7Q095_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial genome maintenance protein MGM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_007286</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGM101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q095"/>
    <dbReference type="OrthoDB" id="17164at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009446">
        <property type="entry name" value="Mgm101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404:SF0">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06420">
        <property type="entry name" value="Mgm101p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2182356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="310" mass="34748" checksum="384BC25F1786DDBE" modified="2022-01-19" version="1">MLPVPLRGLIRNSGARSLITRKQAIRAVSTTKTFAAKRSVNLQRDQSTLKSSAKESEASKSIEPEIKAVTTSTEGQAWFPASQQFDTPAAEGIVLDEPSDTHDWSKSFHGLSTQPFSSDVAEILMQPISPDDIEIKPDGLLYLPEIKYRRILNKAFGPGGWGLAPRGEHSISPKNVSREYALICHGRFVSQARGEQDFFDNSGLPTASEGCKSNALMRCCKDLGIASELWQVDPGFIRKFKKKNCVEVWAEHLTTKKKRKLWRRKDGDIGNVSFIHLHMLVFVNTNRLLFSLHKSTHIKKHELEALNKCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0I1</accession>
    <name>A0A8H7Q0I1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_006671</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14136">
        <property type="entry name" value="STKc_SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000770">
        <property type="entry name" value="SRSF protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000275">
        <property type="entry name" value="SRSF protein kinase 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="447"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="393"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="604"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="609"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="658"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2183663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1718" mass="197106" checksum="F5AF9FF4BF2F19DA" modified="2022-01-19" version="1">MTTSHIDYPLERITVPSVLSHLERPASIELTKPGQNAVSLEDWTHSSKQLTIFLAYVIKVQQELVDIMRSRTTAVFLLGESEPLFNGGYLAEIEDQAGGYILFDLVIYLVKFSHLFIPQGHESSQDAMFSLTCTRYFTGPGIWELINRRTTFVAYEEMALRVMEQCKEYNLPVADIHDAVNEETLEYLRGLKTLTFATAPEDGELRCHLQVLLDVGKQETSGVAKTLKTKCLNVNMAKLRDGAGRVFASIVLYETDYQLTWLAESFTDYLIQHAGIIVKYQGLSCFYGNYDEFIEFATYSARNENLPTTVLLPQSLALKEYDSNLAKSRISIMAILCDNSPARIKEFPSTACEWILQHTNNDITYQAINDLETIDALIASDMKAMQVMNHIERDRGHHRNRSYDDGSISSEDVPEEEFENEEEDREDYRKGGYHPIHIGDVFKDGQYTVVRKLGWGHFSTVWLIKDNTTDRHFALKVVKSAKHYTETALDEVKLLKTVAEQNPNAIGRQHVTGVFDHFMHKGTNGTHVCMTFEVLGENLLALIKRYKHRGIPVHLVKQIAKQMLYGLDYLHRECHIIHTDLKPENVLMCIDNAEELVRKSAARAAATIEPDRTDEHDKERPRYDDGHIRSRDGLSRGRSRRRHDHVQMIPSQPLSSDTESRENVDHRGRQRESNSHHSSRSDEAPPALDQITIKIADLGNACWIDHHFTEDIQTRQYRSPEVIIGAKWGAEADMWSFACMVFELVTGDYLFDPQKGTRHNRDDDHLAQMIELIGDMPRAFALSGKQSPEYFNHRGELRHITRLRHWGLADVLHEKYSFRYEQAQELASFLMPMLRAANLAENGLTSPRNKKASAIDVNLDSSAKQRAARSPFTSSMYSNHSKKYDNYTKPLYHNQYGSTQRRLYQRWGRLLVIVFAFLLILSYLPFFSTTPPATTYPPAYERPAQQDGMAGPPGVAPVRDQIVLYRIIGNDLPPRHKEGQTLSNLAFILKHEKPFPDTRKIFVLNRIVDPVNEAAIIRLLDQYNMEYIRAPFVESEYTKVDFRLEDFPEKDFLHSDDYMHFSKVAKLRTLDYTYHEKNLYAMNNNGGRNTAIAHAKSLPDIRWIMPLDGNCFLSERGFGEIRSQLNTYGHNTKYFVVPMTRLLNNSVLLDGSDDRPRTPEEPQLIMRYDSEEEYNPNMRYGRRSKLELLWRLGALENRRSLNRPVVPWEAEERPYSKDKGNFKTVGWVFRLFSGNPQQEENKKEATSIRAFNRLLAIQSYLDALDEKLARRTFRQEHLFLFNENEIAQMRYSLWSGDQDIRKMVDKLETRANQILEHIEGRFAPHGTGHDAMEDDDLAGQQFLKPDFLTDQEPVAEPVNITGQDPNFLGPLADNVTVLALARYFVGNEKYGRWAANLVRVHFLNEYAIDTQEEYNMARVIQDKGHLLDFLSDQGYSFPSLSRVPRIVPKYGSSPIPIPKDLTKVNLAPFLDAIRLLHKSQALTHKEYVELQSIGSEFLEYLVNSPTGIHLAQLPDHRSVLYDLQVSALATFTDDLRLYLRVANRCRMRIGKQFTSSGMQPYQSAFAEAQMTSPGDSQEFDRLNYHYQTLNLQYWTLLARAIQNVGISKDIWHYTPKGGPRLSRVVAQHADTVLAQRDALDRLGPLLNMAHAAYAYSSKDHETRNMMNSADYETLKRRLAQIGGKWDLDPLADMSQSFSDQDGSKTNYGIPVFWMAGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0L0</accession>
    <name>A0A8H7Q0L0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0L0"/>
    <dbReference type="OrthoDB" id="2157859at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="19672" checksum="8386DC9422946011" modified="2022-01-19" version="1">MTVVLPWKIDRHNASHATSNSSNSLYSSSRSSSSTANTSSMEHDAPVQALKPLPALELADPSSRQPTSPVTPLPTPVRSNSLRVQKPSSDNRHHGLSSTSNHDDAAQRKPRKMLGNYTLTKTLGAGSMGKVKLAVHGVTGHKVHIKLHNPFDLRMMYRNTSYTLCALLSTLQRTFYDGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1M6</accession>
    <name>A0A8H7Q1M6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_006415</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="14"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1M6"/>
    <dbReference type="OrthoDB" id="412182at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2183409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="475" mass="54884" checksum="2C3445E173CF2C8D" modified="2022-01-19" version="1">MAVAKSWTPTTWAAIHNAPLPAEGAGNQTFDNRILIGAVVGIPLVLTVLLRWSLWFYPIVALVLALPILAATLYLNSRYSPRYRNRVALPEKPLEEYITIKDPELKAAYNGYNKIPMETFFEAYFEGKIDLKGDALDIMEARHDWAAFRFTMGQFKFFLLQWIPETLWHSRKQDEDQVREHYDRGDDFYEAFLGPRMVYTSGIISDATKRETLEELQDNKLNLICEKIHLKAGDKHLDIGSGWGTLVAHASKYFGSDSTGVTLARNQTEYGNNRIKEWGVDPNQARIKCMDYRDIPSNVKYDKITCVEMAEHVGLRNFQQFLLEIREMLDDDGLFYMQVAGLRATWQYEDFIWGLFMAKYIFPGADASTPLYWYINQLECAGFEIHNIDTVGVHYSATLERWYLNWMDNKEKITSKYGNKWFRVWEIFLSWSTIISRQGSATCFQIVANKNMNSFDRAALICNRTNPKAWTAKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1X4</accession>
    <name>A0A8H7Q1X4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1X4"/>
    <dbReference type="OrthoDB" id="3012298at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00598">
        <property type="entry name" value="GH18_chitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034900484" description="GH18 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="65"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2184919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="347" mass="36434" checksum="2680BEA9762B7752" modified="2022-01-19" version="1" fragment="single">MRIAGLSLIAAVFASAVLAKPTTPSYASVHGHKLQPKAPKISATPLSKAAVKKLDSNVPFSTSGPKFVTYIDNTSGSTTAASFAVPGSAPANDYNVIILGFWLDSGLYDSGYSWAQLDSATRQSYIDAIHASGKKILISAFGAAEWPTSGGVNPTTSAQNLAAIVKQYGFDGADIDWEDNNAMDAGTGEAWLITFQNALRAELPQGQYLISHAPQAPYFIVDTAQYPNGAYQKVNSEVGSSIDWYNTQFYNQGSSSYDTCTTLLTASGGAFPGTSLFEIINSGVSSDKLLVGKPATPAGATNTGYMAPSDLATCLSQAKSKGWDAGVMLWQYTLDTSGSIIGQLAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1X5</accession>
    <name>A0A8H7Q1X5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_000322</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1X5"/>
    <dbReference type="OrthoDB" id="10261385at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000003">
        <property type="entry name" value="Tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000033">
        <property type="entry name" value="tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2184413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="422" mass="47666" checksum="136B6D5D07A27B6C" modified="2022-01-19" version="1">MSEKVTEKLDNLTLATETAAPTAAEVAAASAEQNVTPWDVEGAVVDGVAQAIDYNKLIQQFGTKPIDEEVLQRLEKLTGRKPHIFLRRGIFFSHRELNRILDRYEQKKPFFLYTGRGPSSSSMHLGHLVPFVFCQWLQEVFDVPLVIQLTDDEKYLFKPTLTVDDCRKFARDNAKDIIACGFNPEKTFIFNDFDFVGGEFYHNVVKISRCITANQSRSTFGFVDTDCIGKYHFVSVQAAPSFSNSFPQIFGTKSDIPCLIPCAIDQDPYFRLTRDVAQKLKYPKPSLIHAKFFPALQGSQTKMSASVDSSAVFMVDTPNKIKNKINRYAFSGGGATVEEHKANGGDPDVDVAYQYLSFFLDDDEELKRVYDAYKSGEMMTGELKKRCIDVLQKVVGDFQERRAKVTDAVIDHFMDKNKKINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q235</accession>
    <name>A0A8H7Q235_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q235"/>
    <dbReference type="OrthoDB" id="10267139at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="entry name" value="CofD-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240:SF0">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="CofD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="547" mass="59912" checksum="6C2874988E400A61" modified="2022-01-19" version="1">MSDISYCVFSGGSACNHIVGAFQRTTPDTVYILGIGDNGGSTSELLRVIGGPSIGDLRSRLTRLINLLPSKMESDPGREERAAIKTIMSYRLPAEGNEHDVKDEWSEIVEGRHRLWEPIPVEKKETIRGFLAMFDYEILKRSHKRFNFRNGSIGNFFLTGARLFFGSLEAAIFLFSAITGISEPTSVIPVINTNHTASIAALLENGETLKGQCEISHPSPSSQKEQKPLNPIDAFSRLAFPGSPVAENAPQTNENLVFSKTLEEKLDARIARIYYMNEFGQEIYPIPSPKVLKHLNTKNVLVYSIGSLYTSIIPCLILRGVGNAISQSTSLQHKILILNGHNDRETTGYTALDFIYAITSALNESKLVDARRKFYQHCNNNNTTNGDSHHSQSHSHSQSSLAMQALKIDVGTPLSSSPLSSNGVDILHPKPTRPQLATKQRPYLLTPSPACSTSTHEGYPATTAQPAVTGTPPGYPSFPQDLLSPAPPNAFITTLLFLSNSEIIVDVEAIKELGIKCLEVRGGVSETGKPIYDDNALRYALEFAVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2C2</accession>
    <name>A0A8H7Q2C2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_000450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2C2"/>
    <dbReference type="OrthoDB" id="295656at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041406">
        <property type="entry name" value="CSN4_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18420">
        <property type="entry name" value="CSN4_RPN5_eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="204"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2184541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="439" mass="49216" checksum="867766E92878FF9A" modified="2022-01-19" version="1">MDLQSQLQEITALPQQKNKLSSYKSVLDTILFASSDPTELCSKLHIYVDSILQEQVGLVVSRQALSEFIIAIDEKVNDAETKKDIFPFTIEKIQSRVVSFEEQMSSLREKLASVYEQEEEYVEAAKILQGIPLDSGHRVVSDDYKLKIYIKIIRLFLEEDEAIAAETYLNRAALLIPNSEDLVTNLTYKLSQARILDSKRRFLEACSKYHELSYVSELDEEERLRCLGAAVQCAVLAGAGPQRSRALATLYKDERTQQLSSYPVLEKMFLDRVLRPSEVSEFSSSLKPHHLARLADNTTVLDRAVIEHNLLSASKIYNNIMFDQLAALLNTSSEQAEQVASRMIAEGRMIGSIDQIEQLIFFESGGASVEENGEPVASNVSAATSTGHGVIASKRIGQSMIEAVKWDNAIQSLCHQVEDIIEHIQTKYPDYIQQTGINC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2I7</accession>
    <name>A0A8H7Q2I7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_006502</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2I7"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071507">
        <property type="term" value="P:pheromone response MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000921">
        <property type="entry name" value="Serine/threonine-protein kinase STE7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="69"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2183496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="344" mass="38308" checksum="6CB80C830860CC2D" modified="2022-01-19" version="1">MLAKAPLRKKRNFKGLTLENSPVIVQAADGSPAPTKSGKSLEEYSNLCERLSDLEIGLELRLDLRSEDFSELDELGRGNGGTVCKVLHVRTKTVMAKKIIHVDANLNVRKQIMREMQFMHDCNSKHIVSFYGAYMNGGDIAICMEYMDVGSLDNIYKKNGPIPMDVLRKIAYAVVDGLIYLYDNHRIIHRDLKPSNVLVNSQGQIKICDFGVSGQLNKNSVADTFVGTSSYMSPERIMGSPYSVKSDVWSLGITLMELALGRFPFPPDGGSLSIFELLQHIVNEPVPTLPEGRFPAPLQDFVAKCLVKDVKQRATPSELMNHSYLASAATEKVDLEKWAQSQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2Q6</accession>
    <name>A0A8H7Q2Q6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="12">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_000746</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="12"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2Q6"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000266">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 9 12" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="13">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="10">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2184833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="337" mass="35853" checksum="83360A2AC6953DFD" modified="2022-01-19" version="1">MAVGVGINGFGRIGRIVLRASIENKDVKVVSINDPFIPLDYMVYMFQYDSTHGRFKGTVEAKDGKLVVNGHAISVHSEKDPSQIPWGKDGAHYVVESTGVFTTVDKAKAHIAGGAKKVIISAPSADAPMFVVGVNLDAYKSEYEVISNASCTTNCLAPLAKVIDDEFKIVEGLMTTVHATTATQKTVDGPSGKDWRAGRGAGANIIPASTGAAKAVGKVIPHLNGKLTGMSFRVPNPDVSVVDLTVRIEKAASYDDIKAAIKKASEGAMKGILGYTEDEVVSTDFLGDSRSSIFDAKAGISLNPNFVKLISWYDNEYGYSCRVVELLAYAAKKDGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3E3</accession>
    <name>A0A8H7Q3E3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3E3"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="188"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2185729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="293" mass="33322" checksum="18267F57BF12DD14" modified="2022-01-19" version="1">MSPYSQNDSNYNRPSSPSDVDSLLKPEACGKKRYSLNLNRRTSPDPDTTSSRDSSRKSSYSKRRSSFLLSLKSVLSWRDHGLLSPPASPKAKHKSESRPPPKQNVTGQIKPLPPLPIVDSEATVPERTDYIGSSFRTVYGRKYHICTDHVYPLPVDDDEIDRMQTQHYVLKELFEDNLFHAPVEDKLKDGVHVLDLGCGCGSWCMEMATQYPNSTFIGLDVAPIYPTSIIPSNCSFQSCDVTDGLPFVNESFDFVISRDMALSMRFDDWKQYIEEMTRVTRKNGYIELVEMDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3K3</accession>
    <name>A0A8H7Q3K3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_002271</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3K3"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="265"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2185834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="588" mass="64926" checksum="A0B424D1A32E7D0F" modified="2022-01-19" version="1">MQQLSAGPATDSLCVQQPQADSVIIGSIIPVSYFETQARASATITSYVVDGGDIDMTSLAHAGMTVIDGNLYLAGGYASNTIYTLRGLSLQAIRTSGTLPTGAMSAATLNDTTTNKQSMAMISAADPSMWIYDPSNNLLQNSAAGPQNSSDLILASTGQQLLAYDPNWGKTQQYLPNAGLWTVLNETTPVVSITSPLPTPSCTPTGQMTQSNPVTGDTHQAAKIGGGIAGALIALVLLALMFWLCHRRRRRAIQPDHKYNAQIDDRTNESLEEGAIEAKPKLKRYNFNAKMPSLRMLNTSAITALYPTVAKPASNNIYANPTAPEGTILFKRYELIQSIRLNSLADGTAFRVGRDIKRHGNLVILKFMIDQNEFHKDLSTTQFLRSNYVTVSIDSFELPSSITQHQYISVWEYRPTLASLMNDGRLERDDQLMLRKSARSMCEAVNWIHSKGIVHLQLQPNSYVHERTDPTRWMITDFQHACALTQKDEDIREPIDWTFSLNVYSAPDMFMNEGKLEIPATAELDIWSLWCILVEIATGVPPFNSVMAARKQRLAVRPTDPAVQRLLKTVVDLIPTLASIHRRLINVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3W2</accession>
    <name>A0A8H7Q3W2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_002452</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3W2"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2186014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="181" mass="20362" checksum="C657848DFC3179E2" modified="2022-01-19" version="1">MDGNSLFDIFSVGKTSLMNQYVNKKFSSQYKATIGADFLTKEIVVDDKLVTMQIWDTAGQERFQSLGVAFYRGADCCVLCYDVNTPKSFESLSSWIDEFLIQASPRNPESFPFVVLGNKIDVDESKRMVTLKRAQNFCESKGRIPLFETSAKEAINVEQAFQTIAKNALAMESDVELYRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q415</accession>
    <name>A0A8H7Q415_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_000833</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q415"/>
    <dbReference type="OrthoDB" id="3012298at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00598">
        <property type="entry name" value="GH18_chitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034302860" description="GH18 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="67"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2184920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="452" mass="46621" checksum="B31C44F4CB21EA61" modified="2022-01-19" version="1">MKFLALSFIAALTAAVVAKPVTPPYSAVHGHKLQPAAVNGTNISVSKAKSLAANQLDSNTAFSTNGPKFVTYIDNTSGSTAAASFAVPGYAPANDYNVIILGFWLDSGLYDSGYSWAQLDSATRQTYINAIHASGKKILISAFGAAEWPTSGGVNPTTSAQNLAAIVKQYGFDGADIDWEDNNAMDGGTGEAWLITFQNALRAELPQGQYLISHAPQAPYFIINKTQYPNGAYQKVNSAVGSSIDWYNTQFYNQGSSSYDTCTTLLTASGGAFPGTSLFEIINTGVSANKLLVGKPATPAGADNTGYMAPSALAACLQQASAKGWDAGVMLWQYTLDTSGSIIGQLAPAVSGSGSVPTTTTTTTTAKATTTTTKATTTTTKATTTTTTTKATATPTGSGTCTTSNNGAMVCVAANTSGQYQTCNNGGWITQTCGSGTVCQQSGTSIYCGYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q549</accession>
    <name>A0A8H7Q549_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q549"/>
    <dbReference type="OrthoDB" id="17977at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2186137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="643" mass="71882" checksum="2FA57283CC1897DA" modified="2022-01-19" version="1" fragment="single">MSSYPSNLKTKTPNPNPVQYTDMVRASSMHHQPPGRGQPSRRYPQQYRPRSFSHARGQFRGQPRFYPQQFQHRRFSASSDMPKASLAKWRSEQEIFRDNSGEQAFSVSLPKKGLHTFPWSDSGDRNAALYAKRSKPQSYPKDTLLETRSKIPLKFPSPAITRRKSSSHKDQSAPDRPPRSPTASAAQGDQHLQWIEQWTPPPRSPTDDRSKNGYDVDTSEETSDLDMEGKGLSEAIQPSQQFALNGTATVPNDERGELNGEAKAHADTKPNSESHLGPLDPEKLPETPVSETASDNSVTEEQRVGAPDLGDKTGSIADLTLTPQSMPSQASADVDNQNPPDHPKSIESDHETEITKEMPSPTPDISSQPAQDLAEEPAQSQSTATDEGEVNTAKEAEGAREAAEASEALQDPPVPTSPQEQDFPHTPLNSIKEEEVLAEVPVWADSEKVKQHPEDYEKVMRFLKEHEIANDSSLPLSHNIVFYFSDTSTAKSKNANSYSATIRPMFVCETVWQFSARWRKFKERFSAPSFMLPNQNLYFFKQGIEPMWEDPVNARGGRITLSPTKMTLDELWEVVLCSFVGATCHNSIVGVVMSRRGRGDRIEIWMDEQGKEASEEVRAELSSMLPPIIQEVVQAAKYKKHFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U6S3</accession>
    <name>A0A8H7U6S3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc finger ZPR1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_008136</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a protein folding chaperone for elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZPR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U6S3"/>
    <dbReference type="OrthoDB" id="308464at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000002">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000003">
        <property type="entry name" value="Zinc finger protein zpr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="29"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="241"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="403"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2171756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="453" mass="50619" checksum="CD129342F00D9CA6" modified="2022-01-19" version="1">MADQGNVNTAPEPIFVDIGDSSKPSEIESLCMQCHDNGTTRLLLTKIPHFKEVIVMAFECEHCGFRNNELQSAGAISEKGHTVTCKIDNKEDLNRQLVKSDYASVKFMELDLEIPSTSKRGVLTTVEGILGNAIEDLAESQPVRKHVDENLYNQIQAIIEKLESYKDNNAPFTIRIDDPSGNSYIENLCLPAQDPKLEVRWYQRTPEQEVQLGLRSADEPETATENAEDNEVAPEIMTFPSNCSHCNAPSETNMHVLDIPHFKEVIIMATNCQHCGYKSNEVKAGGAIAPLGKRITLRMTESDDLSRDILKSETCGLSIPEINFELTPGTLGGRFTTVEGLLRQVHEELDQRAPFLQGDSATEESRVRWQAFLDKLQQVADGELFPCTLVLNDPLANSYLQNLYAPDDDPEMTTESYERDYETNEGLGLNDMKLENYEQDGATQDHPMGEAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U760</accession>
    <name>A0A8H7U760_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U760"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="75" mass="8316" checksum="6F5787520A9865C0" modified="2022-01-19" version="1">MLNKVILFSLAAKYTDATGTPFGMFKNIRADGPTVKAITGIAILTMKTMIIRSQKQGRDQPRREGYGFIHDADVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7D2</accession>
    <name>A0A8H7U7D2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">INT43_002897</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="15"/>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7D2"/>
    <dbReference type="OrthoDB" id="687049at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16656">
        <property type="entry name" value="RING-Ubox_PRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000027">
        <property type="entry name" value="Pre-mRNA-processing factor 19, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055340">
        <property type="entry name" value="RING-Ubox_PRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24814">
        <property type="entry name" value="WD40_Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 15" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 15" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 14" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="U-box" evidence="18">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="249"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="299"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="355"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="385"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="139"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG2171275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="504" mass="54875" checksum="84D50F906CACF7FC" modified="2022-01-19" version="1">MFCAISGEAPEQPVLSTKSGLVYEKRLILKQIGDTGKDPNTGEELAAEDLIDIKSDPTTVKPRPPTLTSIPSLLTVFQNEWDSMMLETFTLKQQYQQVRQELSHALYQNDAASRVIARLLKERDAAREALANVQAHLGTQAAPAATESESMDVDSQESGLPAEAVEKINATSEKLSATRKKRKPPTEHASAEAVGAFTQTESVPSMHNARPAGVTALDIDDKRGNVLTGGNDKHVQVYSREKEKVLANLTGHTKKITSVKFRGDTDGSEEIDIAVSASADKSVRVWGTGEKGYGLLHNIHAHKSDVNAITVHPSKDYFVSASSDSTWAFHEYETGSTLLTVSDPETDAGYTAAHFHPDGMILGCGTADSTVRIWDIKSQRPAASFTGHTGKITALNFSENGYILAVASEDNLVKLWDLRNLTNTKTFELDEGYKVHDLKFDYYAKYLAVAGTDLRVLKAKDGASIATFKENTGELTGVHWDPLAQYVAAAGLDRTLRFFSTASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U884</accession>
    <name>A0A8H7U884_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_008363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U884"/>
    <dbReference type="OrthoDB" id="2352099at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2171637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="295" mass="33402" checksum="D50436EABA1F18CC" modified="2022-01-19" version="1">MGETLFSLLDLTHFTEASDHKQPASTRVSGPIDLTYEQRGGIILEEWGKKWQTIIMEAETALSEPRNPMSDDVYSRFLAMGFYNEIIRKLLAKTITSLIFSKESKFKLCYWAHIYKGMTGNTSAPISKVLGRESKLLKLDDINMSMTDEDRLNRGVSAGEGWRTSLMYLLAVSRKYPQYISKVAARDTAGYLERHRGHGNYAAPMITSDQLGDCGVYLSNTGDAGYGISFHIESSVTKALSLDESEVTFEDAVRLRKFVSIQNWDKTWHFEDFEPITMNNLPQAFSHVTTNHIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9Q6</accession>
    <name>A0A8H7U9Q6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9Q6"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034857152" evidence="2">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="80" mass="8460" checksum="9EC522049836A527" modified="2022-01-19" version="1">MQYQVALFFCLALLTLVVSAKDHDRDNYGYNNNGYGNNGYGGGNGWVDQNGHWHNAAAGQTVMTGLFAIPAAVAAGLLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UA03</accession>
    <name>A0A8H7UA03_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_003093</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UA03"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M48" evidence="7">
        <location>
            <begin position="109"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2177846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="311" mass="35517" checksum="8207BABF20E4DA96" modified="2022-01-19" version="1" fragment="single">RGFHVTGNPQLPYQLQTRVTPPRYQRFNNNKIPFYQSKRFWVTTGTGTVLFGGYYVTHLETVPISGRTRFMDITPRQEEAMAKQAYAEVMNQYGHRLLPPNHRLSIFVTKVAKRIVQVSGMDDLKWEFHVIDSPEKNAFVLPGGKVFVFTGILPVVQNEDGMAAVLGHEIAHQLARHSGEKLSFAKVLFVMQVTLSLLGIDPSFIFNQLMLNFGIMMPFSRKCETEADIIGLQLMAQACFDPREATKVWQRMEAAGDKEIPQFASTHPSHKNRIQRLEKELPDALAKLSASDCSTEMREFSHSFNQTWPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAC0</accession>
    <name>A0A8H7UAC0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Type 1 phosphatases regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_004901</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the YPI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAC0"/>
    <dbReference type="OrthoDB" id="307488at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="14"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2172359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="174" mass="19397" checksum="902A0C1F0EEDE03E" modified="2022-01-19" version="1">MASLLYAAKIINMSAHPPTFTRQREQTTPANDGSRTVTLDPTESQPESDSGDDSIGILRLRGDPHARGPRQIQWADDVVDNEHLGRKKSKICCIYHRPRMPGDDSSSDSSSDSDTDSDDSQRGRGRKHDPSCKHHDHSHGPSGNNKRNPREVSPNAYERQPRYKNLPQPPPNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAL9</accession>
    <name>A0A8H7UAL9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAL9"/>
    <dbReference type="OrthoDB" id="4349954at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042859">
        <property type="entry name" value="NOL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15633">
        <property type="entry name" value="NUCLEOLAR PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15633:SF2">
        <property type="entry name" value="NUCLEOLAR PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="844" mass="93486" checksum="38C547180FA9F886" modified="2022-01-19" version="1">MPGFSLEEPYPLATFKSTSSALVGQSFCVDALPVDTCAPAADSSEPDNAVESNLVAVTVQGEAIKLYNILDQNCIKSWSTPPSVVFNGPARILTKENDGNTDRYIYIAVTSGPDITSKEEGRVVWFWKDCDDTVPVDSTQEAGLKKTTRMFEDKIQAVHVSPAMQSYVVLVNENGSVSLVTTDLGRVVAKGEPAKSGGKIVWSTAITMPSVSGQASFIPTSMVPMASTLVATLTKYKDTYTFTILYINEERRSIDVLTNFDIQPENQPVSYSLQSQKGIFCLIDQDGTWTVYQIKLRHGPSNKVLSDVQKSISLPLNDLEIEKKSKTNLVEPCNTIAMTTLKDNYVAIVTGHKQTSEHQVSIWDVRYGTLQASTTIKNDSKSKDTKDTHIMYKITSLPNGSIAVTVSSLKRSGTTSKQSKGTVISSSAVYLINYYCSPMSLLAAMNTMQTTSQHLNIKHSKLGDGIGIIRSGHEAMNNSLSFEKQDPNQLYDDWVKNVDANQQTENSILAKLTKPDIKAAEFSKTFLAYAKEQQHQFANGEGSEEVDVVMTENGNVGGNTLANPVGSPKSVVESVTNLSYHFLVQVVSNCFKTKDNGKPDMGFWPVDVLEYLAVRGVLYSNFVQGGIVQAVMERESWELLEVVLKHVQDIPEGDLIKVVRTLANKDEGDWSDKFPTYFKLVLEAPRNDIFMQQAMKQLTTSELPIVLKTLRDWMDWWEQHGGGSSSVNSATEAVPGFVHIIDFTNVLLDVHFPTLILEESMHDLVKTLQDKVQEELEVCSDLEQLRGVLDLFHRKEQAREAAPANKARPSDAPHDELSKYRKELKGKFGGEQGVPQYRVEVFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBK1</accession>
    <name>A0A8H7UBK1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_001199</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBK1"/>
    <dbReference type="OrthoDB" id="10251371at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15845">
        <property type="entry name" value="SNARE_syntaxin16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF83">
        <property type="entry name" value="SYNTAXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="212"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2175552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="309" mass="34972" checksum="22EB4F54975A5200" modified="2022-01-19" version="1">MATRSRTLLFLQYRNTLARSSHRSGEGAASYQSDAETAGLIDSSDTVIEMSTLPPKWVDIVDEVEEDIRSIKDNISRLEIMHKKHVLPGFDDRSSDEAAIEELTDDITRQFHAAKNKIKRIGVEGKRGSSQHEQQMSTNVQSSLATKVQELSSSFRKTQSLYLQKMQGQENRKNDILGLETGLSAEAADLLLTEDTSMGFTESQLAMIESSEAAVDQREREINQIAKSIYQLADIFRDLQTLVIDQGTLLDRIDFNIEQTNVHVQHAVVELDQGARYQKKTRNRKLILLLILVIMLLIVILVFKPKRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBL7</accession>
    <name>A0A8H7UBL7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBL7"/>
    <dbReference type="OrthoDB" id="2375764at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2176930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="343" mass="38083" checksum="AC07E2C740D43170" modified="2022-01-19" version="1">MLETAPAPLDGFDMSQHIESKKTHYRSGSLPVQSSQGLGYPPAVANDQRSGSITYTSTKPFMSSSASSLTGTSIRTELDGSVIFHPDEDHAGKRYWEGLFQPERTTIRRIPSSLTPLDKTVSNYSLGTPQSVLPLPAIDRSYPREIPNVSRYEILSSIKELHSQDQLPLDKKQFEKMIDQEKHGLNDRGDTLKEEDLKAIYSMTKRKDAPSVLEDGGGDLYEEEPLYGKWYFWFGFLCPILWIVGGTYPCKGRKTSAFLLWRRRNRAALTVFMTLLITFLIIGLVLKPNFLGVRNSFNDSASPSQNPPNGAGEPQEAVGSDELSSNAPVNAADIPDTQPDPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UC55</accession>
    <name>A0A8H7UC55_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UC55"/>
    <dbReference type="OrthoDB" id="333905at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAG" evidence="2">
        <location>
            <begin position="298"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2174159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="589" mass="67562" checksum="FA3AFE9A4191FE64" modified="2022-01-19" version="1">MFAYQYASHYPYRTSLGPFQANCRQYSLEEDCLQDLYYQHLVEEEKKHRAASLQHALYAAYEREQIKRAQELAYRKQLAYRKELAYRKELAHRKEMVYRKEMAERRRREYFESYEDRILNHLIGNLLADNEEEEENNTATIYCRNEFDNGNCRKKARRSYQEPEPSPQEEQEQVWLLLHHLKALNTSESEEESSSVEGRAQIAKRNESKKQQVTTETSESSKPKESANNDSDEETYSEDDINKTFSTLNAISTKLDQIQEQHEAQILASPLTFENESEEILAKTISNKHFLTYEDDIMKVLLELDAISSHGLPEIRNKRKELVNKSEKLLKVIDDYKQKEWERASSSSSHDSDEETEAPEAQKNNLYVSEDSTAEAEEETVATDSTAIAVEDEEEVTASEAHAINQEASENSADEFAEPSSSNVNQKSLDSELSSIQEDSESATAENYELPLINTDNEQDQEMQVDNETSNETEASTSVSTNSPQNDEGRTENDPADEVSIKLVNEDGMEEDDGFEHVHSESQDNGNGQIISQETNDLEENDFDMVDHVDVAKSDDMEEMKEESLAASSEVFSDKKSGPHRIEIEWAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCQ5</accession>
    <name>A0A8H7UCQ5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrrolo-quinoline quinone repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_005802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCQ5"/>
    <dbReference type="OrthoDB" id="408177at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34512">
        <property type="entry name" value="CELL SURFACE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34512:SF30">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN ASSEMBLY FACTOR BAMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrrolo-quinoline quinone repeat" evidence="2">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrrolo-quinoline quinone repeat" evidence="2">
        <location>
            <begin position="159"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2174744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="272" mass="29622" checksum="A668E971F342CDBB" modified="2022-01-19" version="1">MSTAHNRHDLLVVSSHGHIYCLHKKTGFRLWRNDFPGGRTGGLVSLFINDTDQLLASAFGKTCCLDLFTGAHRWTNNMDVSLICINFDLDVDRIINCGLAQGMGYHEISLMATPTNNHSITYQPPANEKSGFGGDQSNYSNPPEYASNDVSVVLACSYGKVMGINSHTGQSIWRFDCPGGGFNLPSVLAEKDVIFIGCGRMVYALNPKNGGVYWETKATNGLVGSGWLTMATVWGSRQAEIYTSVNNCPLPQHKVEEDRRRKRSNGGGGGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCZ9</accession>
    <name>A0A8H7UCZ9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Golgi apparatus membrane protein TVP18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_006046</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TVP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCZ9"/>
    <dbReference type="OrthoDB" id="5591789at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019365">
        <property type="entry name" value="TVP18/Ca-channel_flower"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314:SF2">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10233">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01077">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2174984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="13596" checksum="98CA362A9F712664" modified="2022-01-19" version="1">MGLISIVLLIVLGIVSFLSHIVFSIVGWVIAFILIFVEVPLCMKFCPTSPRFDSFVAFFENSWFRAIMYLVFAVVMFLSNLISTGPLIAAAVALLLAAICYGFAAFRGQAFASTSMLGGTGVDNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDV8</accession>
    <name>A0A8H7UDV8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDV8"/>
    <dbReference type="OrthoDB" id="10258930at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000025">
        <property type="entry name" value="40S ribosomal protein S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00292">
        <property type="entry name" value="Ribosomal_eS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_eS28_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2177952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10474" checksum="3E3A56BE4185F7E4" modified="2022-01-19" version="1">MLLRFSNPSPQHIHNAILCRPTPILLDASKTPVKLAKVTKVLGRTGSRGGVTQVRVEFMDDTSRSIIRNVKGPVRENDILCLLESEREARRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDW9</accession>
    <name>A0A8H7UDW9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDW9"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2182091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28861" checksum="214701DF2CA48F5C" modified="2022-01-19" version="1">MPTYNQPTKNSSNVELADFASSVLLMIWYNASYNEASVQKQPFRQFCRNILSTMQVSSSVVILALKYISLVRQRHSQTGETGSEYQLFVVSLMLASKFLDDSTYASRTWAQVSQIPIAELNRCEMEFLDAISYSLHVPELKYLEWLKYLEELIRQPQLVMHAKRSRTTMEGHMKRRRVSSLPPSYQPYHTPTKINHHYQAMASIPSVAPPAAPPSSSTATFAQFDPMMLMPFISNFSLAAKMRHIPHAGHVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UE11</accession>
    <name>A0A8H7UE11_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_003370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UE11"/>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="43"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2178117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="203" mass="22573" checksum="932B8B6CBC3A3C11" modified="2022-01-19" version="1">MAALNLPADVAASADGSRKLFNKWSYEDVEVKDISLQDYIQVRQHIFVPHTAGRFASKRFRKAQCPIVERLTNSLMMHGRNNGKKLMAARIVQHAFEIINLLTDQNPVQVLVDAIINTGPREDSTRIGSAGTVRRQAVDVSPLRRVNQSISLLTTGTRESAFRNVKTIAECLADELINAAKGSSNSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEB9</accession>
    <name>A0A8H7UEB9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome assembly chaperone 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003608</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PSMG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEB9"/>
    <dbReference type="OrthoDB" id="17536at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080129">
        <property type="term" value="P:proteasome core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016565">
        <property type="entry name" value="Proteasome_assmbl_chp_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15069">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15069:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16094">
        <property type="entry name" value="PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2179825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="266" mass="29231" checksum="E4DADF4103D4757E" modified="2022-01-19" version="1">MDFSDEFATIPTRYAFDDDSDQEDIDQAVDKLDLETFKVDFNNFDTASINTVIFGVYGPGDVFLRAVYEGQSVVGTIYAKTKLLASMHTSPSAGNVISVVSEDVLPEDAINGFAHAMLSKLPNANLRVIVLDSYYESGYIASDLSEQYTEPTLKCLRTSVEKKASQSPTSIDSLPAPNLSKGIAAAILTYCEIHQLPGLALFSPQPASLGKNLITEATIDYYEEALGKIGVDHLRSDQEKVRRAIQSRKYGKDSGKIDADHHRMYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UER8</accession>
    <name>A0A8H7UER8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UER8"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2180290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="85" mass="9098" checksum="D7BB9E6BBA278C44" modified="2022-01-19" version="1">MRPTSSWSIPEVVGATLLVKTNASLVLIDSMKMADNIIRGEADRRGSIWPSVYHLLGEADAEYGGLKVSSEIMSNGFCSSPLAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFD6</accession>
    <name>A0A8H7UFD6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFD6"/>
    <dbReference type="OrthoDB" id="277832at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009210">
        <property type="entry name" value="ASCC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360:SF1">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="53"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2177863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="356" mass="39824" checksum="8AE8ACA450E06B37" modified="2022-01-19" version="1">MSKLMAKSLQGFSIVTAKNKQYRVATASLDAKSTTRSSAPRQEIRHPESQAEEDTELHHWVEHPVSRSMHGYIIGKAGSTLKRIKHETGTRIDVQKGEDFVKIKGTDENIERAKVAIDTLIIAKANPTHFLSIPISSLSVTRKLEEFHKVLESPSFVADGISMDSIAPIPSLHITLGVMKLMGQSEIEAAVRFLKESSANLIHETMTERGITVRLKKLSTMQGHPAKARVLYINVQDESEGKVLDKLCDRLRTQMVEAGLLIDEKRPFKMHITLLKKNSFRSNHNTVKDVNTAEEENNNLEQAHNDDKAWFNASSIMKEFGDLDLSTVTLDSVHIMKMGMNKQGVYKSEGAVVLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFW8</accession>
    <name>A0A8H7UFW8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUF590-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_003961</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFW8"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="601"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="638"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="8">
        <location>
            <begin position="35"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="7">
        <location>
            <begin position="211"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2180172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="739" mass="84812" checksum="1B1F150CED98DD65" modified="2022-01-19" version="1">MTESATQGLVDTGRFSHLFPTTSKQYAAGIPNSVVDYVIVFRYAKNPPKNTSREAYASQVSQDFESLGSKLASSGLLYQVKQGAEDNTLLILVHCPWSVLKKHLFRSRIHDFLIGVRVEDVDESGRRDSGHAESKTDENELPRHDLTEAERLRLVYDMITLPVNDGGANVSPDTDKFVDSIFALHNDELNKSWIQSWNKKWLIHETDLQLIRDHLGEKVAMYFAFLQNYTLALAVPAVMGVIAHFTLKNTFNIFYGIAMMIWSVVYLELWQRKERNLAVKWGVRNFSRHDKQHPGFTGDTVVRDAVTGEMVPYCAPWRLFMRRVLTLPGVAIAAAGLSVVVGFVFMVEVFLHEYYTGPFHQFLHYAPTIGYVLLIPTMSGFYTKWVKVLNDWENHKTEAGWEYSYTQKIFVANFLVGYLSLFITAYVYIPFGEHLLPYLDVFNIQHNHQKVGTERLKAQLMYFIITGQTVGFFTEMIVPRIKAFILPKVMTYFNKGKSDKKISDSNSTELDAKTLEAKDVMTEAENKFMQKVYDEVAMEEYNIYTDYVEMVIQFGYVSVFSTIWPLTALCCLINNMIEIRGDAIKVCKYTRRPTPRRAESIGPWLGNMQTLAWLSSITSASFAYLYRSTTDIHSPWTPIFTIMAIMANEHVFIVIQAIVRYAIQLVPTWADIVARQQEFKLKKTWLDRTANEEQFVAKDIGSKEEASNNELDMFWMEHQKPESELEAAKATIRSSFKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UG57</accession>
    <name>A0A8H7UG57_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_003267</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="7"/>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UG57"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF26">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034487532" description="Beta-hexosaminidase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="11">
        <location>
            <begin position="43"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="10">
        <location>
            <begin position="186"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2178014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="571" mass="64663" checksum="632612CC7B83B4A6" modified="2022-01-19" version="1">MIGNLSFLYLAAIAFGSVNAADHGGKQTIMGLPANNPVKQPWIWPLPQKWERGNATLQLSNHLNFNYHGHSDILRSAVKRYENLIYLKDDYPMIPYNWSTTNEHVQSSLSSIDIDIQDSSENLDMDTDESYNLTISTSGQATIKAPTVYGALHAIETFSQIVRWNPDKKAHLVPNAPWKISDYPKYKHRGILFDTARHYYTPKDIYKVIDTMSWNKMNILHWHFIDSTSFPYVSKAYPQLAEKGAYSPAHTYDDKTIKAIVQYAKERGVRVMPEVEAPGHSTAWAYGIPEIGTCTDIVPYTGFTVQPPTGQLNIASNKTKEVVNTIIDELSELFPDSWFHASGDEVVMDCWSNDTEIAAYLKQHNLTTLELFEQFVTGMQDHIRTHNKTVMVWQEMILEYNFTLPKDTVVQVWVGSSGVKATTEMGYRTIVSSSDYWYLDVGYGKPRSNPYPDVAGAGYNHWNRVYSYDMRANLTSDEVELLMGGECTLWGELADHTNFEGKIWPRASAVAERLWSGYETPSGENITSADAILRLLPWRDAMLLRGTNASPLNQGFCTRNPLDCFQPPETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGD2</accession>
    <name>A0A8H7UGD2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_000689</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGD2"/>
    <dbReference type="OrthoDB" id="6604018at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF3">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="7">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2184776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="101" mass="11136" checksum="1CF68E25AF5140D5" modified="2022-01-19" version="1">MSNPEEFMKEAYEETRLQKLTRKCKEEPFVPAGVALTCFALGAATYGVKKGRRSYANNMLRVRVAAQGFTIAAMIVGSFVYSQNTQASARNNDSSQTSSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UH03</accession>
    <name>A0A8H7UH03_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carbamoyl phosphate synthase arginine-specific small chain</fullName>
            <ecNumber evidence="3">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Arginine-specific carbamoyl phosphate synthetase, glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_001715</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UH03"/>
    <dbReference type="OrthoDB" id="434at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000016">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000003">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF7">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbamoyl-phosphate synthase small subunit N-terminal" evidence="14">
        <location>
            <begin position="53"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2178869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="453" mass="49296" checksum="25E6B47A18A51A6C" modified="2022-01-19" version="1">MPVLTKFAQAALRPTMFPKNGYSLLAVRGFAAVSDTPVSQPVSPFQYFNKDATPASLRLSSGQVFNGTSFGADKSVFGEAVFTTSVAGYPESMTDPSYTGQILVFTQPLIVPKFPSHPLVGNYGVPGETKDEFGLLKYFESDRIQVQGIIVNDYATQYSHWTAVESLGQWCQRFGVPAVSGVDTRAIVHLLREQGSTLSKIAVGNDALVDNSSESIAFPDPNKENLVARVSTKVPLHYNTSGDVKIAVVDCGVKQNILRCLAARGAAVTVLPWDYDFNKVKDQFDGLFISNGPGSPTMCTETVNHLKVAIDTWNKPIFGICMGNLLLGMAAGLKTYKLPFGNRGHNQPAICVDNGRCHITSQNHGYALDDRNMPKGWKRFFVNANDGSNEGIRHETRPIFSVQFHPEAKGGPQDTEYLFHDFLQAVRAEKSKNSTIPASAISEETATPVAAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHN1</accession>
    <name>A0A8H7UHN1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003992</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHN1"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="246"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="276"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2180203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="351" mass="39867" checksum="D86B14AB23A3C702" modified="2022-01-19" version="1">MFKSFVNIRDLEAGTAQHLEPGFSTELITAEDPLWPESTGHHQLQCTCQCNTHSRPLSQRTMWNLPESINQTHYMESQWAKDTTASFALTDYPSPVASPTCETYLHASSNMTKGEYDYYSKPDLTHYVILKMEEFQGLTDYGHNTTDGTAYGNMLATPDSFKDMTGAEIYGDEDPATPGLIPAMASPALTEKDMLQESSNREFLIYQGDNTLFKSSPPPPKDRQLIPETPNRQTYIKSTKSQPSTYKCDYPHCTATFTRPYNLKSHKRTHTNERPYACSHEGCNKAFARHHDRNRHTKLHMGLKPYSCPHCKKCFARQDALIRHSKIENAPCSQVVPAKKVPLKFKFLNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIT8</accession>
    <name>A0A8H7UIT8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008956</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIT8"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF1">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="348"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2181373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="644" mass="74052" checksum="76473D9400FDF41B" modified="2022-01-19" version="1">MKNQLMQHQEEHEMVPDTSNARNIGLDQRQNEGDEGFDWEGDDSGEDHKYKAENRVGTRTLHNFIKRSLFKQLVLVLVDGILIAITAVIHVQFADKETDVSRNLELWFVFLSFIYTMSLLMIGLVELIPSIVKRFVRSMTPTTLEMLKMRLEAYSERIAHNENAIRVLDILKKSLRKKPEFAPNQHDKARHSWANGKSDGQIKSRKSETSNSDLSMDEKGIKHQEDTDDRGRSESCSAQLQKDTVEIPIPSPQRSRCIPFHKTLSESCRKRPSLSARSNAFDAKSFIDFGASNLKSVFGSKAKSMAAFLPTSRTSRQEAKWLARQLFNNMVAPERDVLVKEDFEEYFATSEEAKRAFDVFDKNQQGDISKREIRNTTLQTFKERKNLAASLRDLSTASGKLDNILLAAFAVLWTIIVCAAFGVDVGTQLLPLWTMFVAVSFIFGNSAKDMFDSIIFVFVTHPYDVGDRVYVGIENFVVEEIDLLTTTFKKWDGTKLYARNAVVAPQYIYNLRRSGPMAEVIEMNFSFSTPEAKFNQLRERMLQFYNEKHRSFTHNTMCMNIMTMENLNRVTCIFYIEHAGSWQDMGFRWSNRNAFIMHLKRTMEELGIDYFFPVQPVARINDVPEELSDFGGTSRDYGLRNIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJ31</accession>
    <name>A0A8H7UJ31_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_006598</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJ31"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12121">
        <property type="entry name" value="MARK_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="KA1" evidence="10">
        <location>
            <begin position="483"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="238"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2183592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="533" mass="59241" checksum="71502FA51D1DED5A" modified="2022-01-19" version="1">MEVVRGMTGFEFGTEEDIKAQLEEIISTPEYQSAAKIKSRSSIEFINNGAFNKSHGLHTSKKTFIIPNDDPQSIPAAYHPLISIYYLVKERMDRNRLMEQQDSLDVLMSQEDFSRRRPSRDILTGIPIPTISKPERAHPADLTYEQSILGTDEGDGLSGLAYGRRGRANIRLHPDGHILEIDGHSVGDKIEEGLNRLFSRRHNSQSHASNGDQSEAEIGNENEHPGVFRRLSLALGKGESASKRYERRSSFQKRAAEPTSPIPIPGTSPDLAAQHISRSSPEGSRKSHEQHSRGFNGFHLRPADDKENNQSGTIQPHNTSGAKKYISGKVPAQQLPGVEPNRNGKDYEAGPIPVSSRSASVAASQRKQPDRRGSAYSYDRNDANPGENGTVDQSIRPVFLKGLFSVSTTSTKHPSVIRADLIHVLERIGVKWRESKGRFECVHVPSIDLYGTKTPELQPVQEDEVANHTNGQTNDLTRTGASVGVPDLVVRFEIYIVKVPWLLGMHGLQFRRVGGDPWQYKNMCSKILNELKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJB8</accession>
    <name>A0A8H7UJB8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_008671</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJB8"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF1">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="171"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2181089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="480" mass="54257" checksum="51C4A75934F4AE48" modified="2022-01-19" version="1">MIPFSNYVFVCHNNKKAIKFHKVAYNDRLKENRYALKILDRLSKAERRSRTNTPGGNGGGMRQRRPAYSRHSSFDPANLTDDANGHSISDYDSPNKRPSSGVATPVVFSQLQKKLHHIVLTDTPDARSRIQNSKVDINSEEFAKKVARKLFTSLGPNKKRLTLSDFEPYFATQEEAESAFAVFDRDGNNDLSRREMRDTVLAIYKERKALAQSVRDTSQALGKVDIMLLIITAFCTLFTTLTVFNVDIWRSLVPLGSFMLALTFVFGNTAKNTFESILFLFVTHPYDAGDYVIIDTQTLLVANMGIMSTTFIRSDGQEINAPTVVLMTKFINNIRRSGNMGESIYVDVNFSTPSDKLFELRTRMQDFLAANSRDFQPGFDIKLNEIVELNKMTLLLYLEYKGNWQDGGRRWERRNRFMYALKDALTELEITYDLPSQKVVTSQAGDLPSIQAETPQSFSAGLGSARRRNNTGSTFPDPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJD2</accession>
    <name>A0A8H7UJD2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJD2"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034949182" evidence="2">
        <location>
            <begin position="19"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2181958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="289" mass="32313" checksum="56D2BE738D3FACE9" modified="2022-01-19" version="1">MRSLSLVCLFALSASVTAYDKIIAFADSFTDNGNDYKYSKFPPSPPYWKGRFSNGPTWLEEVAKLMPNTTVINRGFGGATTDNKYVHAEFNGFEVPGLLQEIADYPVPGDENSLFVIYIGYNDLNSIINPDQYVVTTALTKEIVSDNVIKGIMNIEQKYHGKQFLVMTCPPFDKWPVVKDADKAKANELITSYNALLKSKLDKLTNVEIKMADTHAWFEQAIANPEQFGLRTDNGPCVPGIGNTDECSDPDTHFFWDSYHPEAKVHKAEGQWATKLIEQLYPSSNSTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJF4</accession>
    <name>A0A8H7UJF4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_008776</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJF4"/>
    <dbReference type="OrthoDB" id="10251073at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="117"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2181194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="23197" checksum="0B6239D502A26D6D" modified="2022-01-19" version="1">MKTVSAKSVRKKLENINNCSYSDQKKQIDALIMEVYQSLQSDDESSEDEPLARPKSSSKDSKSQKASKSAEYDAYVVKPSESKRKASSKDKEKKAKPAKKRKTKTPSETSRGAPNNGFMKPLKINHAIKVLTRSTEEELPRPEIVKRIWAYIKEKDLQDPSDKREILCDDVMKSVFKIDRVHMFTMNKLLNEELKAIADDDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJP4</accession>
    <name>A0A8H7UJP4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">INT43_007215</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJP4"/>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="16">
        <location>
            <begin position="5"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="15">
        <location>
            <begin position="202"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="14">
        <location>
            <begin position="343"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="83"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="96"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="229"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2182288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="494" mass="56445" checksum="4C7BEC23778D29BD" modified="2022-01-19" version="1" fragment="single">MKTYGVTPPLSEAEPTEREWRLNRSLNDVLVQERMVESEERTKLRESVLFELGLIVNDFVYQVTAEQQPPEIARQCVAKLFTFGSYRLGAHSEDSDIDTLCVCPRHIWREHFFTTLADILRRRPEVTELTPVSNAFVPVIKMVFSGIHIDLIYASLKLPTIPADLDLNDDLRIGELHAKSLRTINGPRTASEILALVPNVETFRTALKCIKLWARRRRIYSNAMGFLGGVAWAILVARVCQLYPNGCAATIISRFFRIFSSWSWPSPVVLKQIQNVNNAWEQKKSANHIMPIITPTNPAMCSTHNVTRSTMWIILAELRRASSIVDEIMLGTTSWQNLFKDHDFFDLYTFYIRLNVCSMDPSTQVAWCGRIESRLRHLVTWLENKGPILVAHPLTDVASKDHPELSHKEIQNVAFNDIVPNELSNSSSTYSANGKSTRKLYVAKYYIGLLLRPVNGIPKSLDLSKEIWKFIGNEMYTYEHFDDKSMGITAKIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKS3</accession>
    <name>A0A8H7UKS3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKS3"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000250">
        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF20">
        <property type="entry name" value="LANOSTEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="125" mass="14715" checksum="F6121A7A618DA5C3" modified="2022-01-19" version="1">MEDENTFFLDIAPVKVLNWLVVYYNYGKVSKEFQQHVKRNADYMWMGPNGMMMNGTNGTQLWDLTFIAQACSEARLVEYPLFQSSILKVLEFLDDCQIKRNVPDHEKCYRHVSKGAWPFSTREYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UL34</accession>
    <name>A0A8H7UL34_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002157</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UL34"/>
    <dbReference type="OrthoDB" id="2284405at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000002">
        <property type="entry name" value="Serum response factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="45"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2185722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="223" mass="24718" checksum="FE89475EF4F0EFEF" modified="2022-01-19" version="1">MSLQTQLESEKNLQLPADSYLIAGRSISLEDDYSDDLVETPDRRSGRRKIKIEYISDKSRRHITFSKRKAGIMKKAYELSTLTGTQILLLVVSETGLVYTFTTSKLQPLVTKSEGKSLIQACLNSTETQDQSPQTNQTSSTSTSQYRANQFCREKLPVGQDKKFHSMNEGGVVSGGGLVASEASFNAPPRQFQQKPGADSYHVAGRQEAHYSMPHSLYATNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UL71</accession>
    <name>A0A8H7UL71_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Kinetochore protein Nuf2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_002279</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NUF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UL71"/>
    <dbReference type="OrthoDB" id="8194677at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051383">
        <property type="term" value="P:kinetochore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041112">
        <property type="entry name" value="Nuf2_DHR10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18595">
        <property type="entry name" value="Nuf2_DHR10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="13">
        <location>
            <begin position="16"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Nuf2 DHR10-like" evidence="14">
        <location>
            <begin position="278"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="350"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2185842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="50243" checksum="B957C8F7156CF60F" modified="2022-01-19" version="1">MYATRRNHAIESKVFYEVPTLSPPKLLECLNEIQLPFTEEDLLKPQALRTQYLFERILDLLMGVRSSQIEEVRDKALQNVENPVTLFCQEMHHDLLGLMLLYDRMSKLMLEIGFADFSFKDMTRPTHHRIIKILSSLVNYAKFREQRLTTFEQVSAVGDEVAMNRANLEQIHEEASAKLNQLREKMEAEEPETKAKKAENEEYGRKLRDQNKVANSIHTRYQELKAVQHQLRDELLTPSLLQQTKVYQIITIDREMERLRLRADQNPERVRTAIAKLSSSIEEENQAATENEATVRRLQAKIDTISSILEEVNSCVRLLSDCEEGLKNFEAFKRQNAINEENITKKSLEMQELINKEQYLSRMLNNLTQRISKMEQQQEKKRESVQHEIEQAQQEYNQTNSEVSKMQQQMSEIQVNAEQLEQQVGISSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UM79</accession>
    <name>A0A8H7UM79_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_000841</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UM79"/>
    <dbReference type="OrthoDB" id="10006270at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF9">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="417"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="451"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="519"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="663"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="709"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2184928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="776" mass="88767" checksum="060186F4E2CD2567" modified="2022-01-19" version="1" fragment="single">MQPRSQVSRRTRSTPLRNETLLDSSPPPLQSPLQTPSRISDISISPIPLNQSQYLPSNLSEASRSSISLTPLAVRQAARLSQHNDSLLIPSSPPIHDQFLPHPSPIRQPLEKASVVDPFSQATTEERLRVLRHDALQQHLYETAAYFGEKVMAMTNDTNDVYWLAQVYHHAGQYGRAADLLKKRKTWSQSVACRFLAAQCAIELENWKDALDLLGHDNPFANKEFHHVPTTDGGIKLEASMCYVRGQAHMKLGDIEKAKACFKEALLVDVKCYNALDALLSYNMFEEHLGRRYLEWDFIYGLPYQDQCGDDADLFRSLYIIKLKKYSHQHVVAEAQDKVERFYGLEFSIDVMQSRVETLLTQSKFEDCLEMCKRIRREDEFNTAYVPAYLTCLFELKKKTELFEFANELVKQIPLAEVTWYGVGMYYFYIKNYTEARRYFSQATTINQYFAPAWLAFGHTFAVEKEHDQAISAYATSARLIPGSHLPLMYLGMQYMDENIMEVAFDYLQQSLSLCDNDPFLLNELAVYYYSMNDYEQALEYLERAEELAKGHQSEKGAIWEKLWCNFGHVHRKLKYESGIDYLLAYYYLCRVLSVNPKNSDAQATIGMIYHLKGRIGDAIAKYHEALKNTNNEVIVTELLEKALQRNAESTLELVLSENPDATIDGGGFDIEIEDWDTPKPMSEGPSRRMLQTPKARHEKPSDSSPDPEMARRDSDRGEYDPEGDGTEIIRMEEGDDPFLVDHGDLDPNISGTHFLHKLRASDNPSTSTGSKRKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UN61</accession>
    <name>A0A8H7UN61_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_002341</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UN61"/>
    <dbReference type="OrthoDB" id="29646at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000002">
        <property type="entry name" value="Prefoldin subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2185903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13429" checksum="94376841DCAEE6F8" modified="2022-01-19" version="1">MSSSSNKKPNEAEITQQYNQYKSELQSIASKIGELESEIEEHKLVIESISPLEGDRKCFRMVGGVLVERTVKDVLPALQTNFDGIQQVISSLLQTYKKKEEDFIAFQKKHNIQVVSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCQ6</accession>
    <name>A0A8H7PCQ6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">R3H-associated N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_009155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCQ6"/>
    <dbReference type="OrthoDB" id="10256743at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039629">
        <property type="entry name" value="R3HDM4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32019">
        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32019:SF2">
        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="32954" checksum="23BB69666105A303" modified="2022-01-19" version="1">MLSSSVIFTTTTSSPVQDHTHASALAQERKKRFWLERDSLAKRNQLLVGKEGSRRRQRWDNNNFTDHPFAKLNPADLRPPGYAERPKFHWTDDEAIANVTSEDIDRACRSMELPTFSHTEDPHPLQRSVRHDLKKSHIPQGLVAFYDEQIRQFMERSIIKDVDSLEQDWVLVDESAKSQPTETAPSSEVIPQSNEHSVYLVWEIGDRFSRWIVHTMSQFYNLSSFSECTTTQDQRRLTYVCYPEHAEHLTKFTLDGKAELESSSLPSPTINTTPDKSFYSYLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD13</accession>
    <name>A0A8H7PD13_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008036</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD13"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2171656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="37173" checksum="6136716FE9650740" modified="2022-01-19" version="1">MSRDQRFLLPSYSSQTLYKKRKRQASPTRNSKPSSTLWADPVDAFIHPFKQQDLAVTPAKVKCVRSWIHDSLATGTQNGNKLLIISGPSGCGKSTTIRTLAHTMDFDIQEWTTFGSTAKWDDLVDKQDYESLMTNFVDYLTRSLRHDRTIHTSTSNSTKARRKVILIDDIPDLMYGTSRRRFHDLMRGICRPSDSHVPVILTLTTLEERRGSEPRRGIQKNIYDFADNGIIPTDLDSIRYTSTTNKRLEKIISAIYKSEALDVPIDFDVITAASHGDIRSAINNLQFYAIPKKQDGGTGSDNHLPAGAIGRESPLDLFHAIGKALYAKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD46</accession>
    <name>A0A8H7PD46_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_008100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD46"/>
    <dbReference type="OrthoDB" id="2276217at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034229586" evidence="3">
        <location>
            <begin position="18"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2171720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="269" mass="29328" checksum="019B945A615345BB" modified="2022-01-19" version="1">MILPPILLYFFISYAEASSALDMITVNCTWPCPNTADVCQVTGTTIQCAPSSNSQWVMKTSTTSPVFTGDTATMNQPCISAPNPIKATQPYTNITSSKPTTSNIAWPLQDSERPFDAFLSNCDSTTYCSPAISQCIPRISQDGYCNSTNECNNEQQCISGRCNGGETTWAPQGPQTSHLLAGIISAIVAIIAVIIAGVFYIRRRRRQPQLGSIAKKETVQDALASFEQCFESDHTTPAMQQRHLQMRLQQEHSIGDKGDMSSSPPPYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD78</accession>
    <name>A0A8H7PD78_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_008157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD78"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23164">
        <property type="entry name" value="Prefoldin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2171777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="14028" checksum="0467DCEE1B3AD914" modified="2022-01-19" version="1">MSALNDETIRRVFVDLQSKYISSMQQANSMKQQIQIKERERKVAELTRRELEALDADTKTYKPVGKMFIQTPLTEMKQSFTKRVGTADDEIKALEKTQKYWERAAADAQGNLKDILGGPRTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDB1</accession>
    <name>A0A8H7PDB1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_008202</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDB1"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005089">
        <property type="entry name" value="CBM19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03427">
        <property type="entry name" value="CBM_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034104487" description="chitinase" evidence="11">
        <location>
            <begin position="26"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="12">
        <location>
            <begin position="32"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="330"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2171822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="554" mass="57768" checksum="8D2EF2A31D1B2068" modified="2022-01-19" version="1">MVSSGYLTTAITAAALFASSAVVSAFDATCNGNYALYWGQDSSNGQQSLASYCQDSTVDIIILSFLYTFYGPGNEPEIDFANEDGGCSYFSGTNLYHCPSIGNDIKTCQSKGKKILLSLGGADGSYGFSSNSAAQAYADQIWGLFGNGNGSLRPFDTAVLDGFDLDIEGGTNTGYAAFITQMRTHYASDTSKQYYISGAPQCPFPDQWLGASLDSAWYDFVWVQFYNNYCSVQGGSFNFNTWDNWAKTSSVNPNVKVFLGLPGSTGAAGSGYVNANTLKSTIPSLRSQYSSFGGVMMWDASEAYDNTEVSPNFATVIGGYVHSGDNCGSSTTTTQKTTSATKTTTTTKKATTTTTKTTSSATPTGTGSCPVNGGSCTQAYACSGTQYAQCVNGKWLFQACPSGLICQLSGNGASAYCDYASGHTAICGSANSVNALAAKPVAVPATKSQNAQVAFVVDEANADATTFSGLFNVRSTSTKAIGNSWTLTFTVASGETVGSSTVGTVSQSGNTVTIKANRKKVAAQSESVLVDIKGSKAGNKVFVGVDPSTINFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDB4</accession>
    <name>A0A8H7PDB4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">[RNA-polymerase]-subunit kinase</fullName>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">INT43_008321</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDB4"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07841">
        <property type="entry name" value="STKc_CDK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000554">
        <property type="entry name" value="CMGC/CDK/CDK7 protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000097">
        <property type="entry name" value="Putative cyclin-dependent kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037770">
        <property type="entry name" value="CDK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="17"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="303"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="23"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG2171595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="345" mass="39415" checksum="A73AF1F6217F32DC" modified="2022-01-19" version="1" fragment="single">MANEIADESNLHTEKKYHKDAKIGEGTYAVVYQGTQIATGRKVAIKKIKIGQFKDGLDLTAVREVKYLQEFKHTNIVELIDVFSHKTNLNLVLEYLDSDLEQIIKDKSILFMPADIKSWMMMMLRGLDHCHRNWVLHRDMKPNNLLLARNGQLKIADFGLARDWGDPGKQMTSQVVTRWYRAPELLFGAKEYSYAVDVWAVGCIFAELMLRTPYVAGDSDMDQLTKIFHALGTPTETDWPNMTTLPDYVPFRTYPKVPLSQYFTAAGSDALDLLDKMLGFDPAKRWTCRECLNHSYFRNAPLPTVPEKLPQRAPEPEKVADTLKRKADSTLTNSDDKAKQRIKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDI1</accession>
    <name>A0A8H7PDI1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_008080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDI1"/>
    <dbReference type="OrthoDB" id="2386090at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2171700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="222" mass="24495" checksum="4C98CED9AB78EFC7" modified="2022-01-19" version="1">MLRLVHIHRLSVQATATPRLFQAILVRHKSTVPKEAAGPFTTNDKISTTSRPEDKTLVYLGPFAETIRKYKITASLFTLCGLCAVPALLATGQAPVAASVMAGISAVTPTGFIHWLSGNYVSKLIVYDQPRNIRRTKDIKITKDMLLELETYNLMGGVKTGKVMLSRLAEEQLNKKAYIGWAEKGSKQRAWKLERAVVEADPYLNALADRIASQSRQGARAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PE90</accession>
    <name>A0A8H7PE90_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004864</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0357 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PE90"/>
    <dbReference type="OrthoDB" id="447314at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018559">
        <property type="entry name" value="DUF2015"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023:SF1">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09435">
        <property type="entry name" value="DUF2015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2172322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="116" mass="13220" checksum="BC6B6641B65BF40F" modified="2022-01-19" version="1" fragment="single">IILFRKRLQEGFSRLADNTNRLIGYHLLPTSAGSFEEDLEDGLTSSNFDIEAHNLEEGDSRAGLKNKEEILKIMKRQGCSFDEARLIRQQRLLKKNNIDPVTGLPKDPKFVSFSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PF64</accession>
    <name>A0A8H7PF64_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_000158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PF64"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2172811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="86" mass="10067" checksum="DAABB65BF2DD2B02" modified="2022-01-19" version="1">MANRLEFSGMVLSSSFYMASKWVHINLIWRLSSSDEFIQVTTDIMQRLIDIVHSIIQQISYIIHNVFKAVTDIETIVRGNAFILYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PF73</accession>
    <name>A0A8H7PF73_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_004742</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PF73"/>
    <dbReference type="OrthoDB" id="192733at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17483">
        <property type="entry name" value="MFS_Atg22_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044738">
        <property type="entry name" value="Atg22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <keyword evidence="4 9" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="335"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2172201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="567" mass="63099" checksum="09A6244038B720B6" modified="2022-01-19" version="1">MSTWKETLFGDPFAVEGDEIDETAQSEAELLAKGNVFEQPAATRGELWGYYLYYNGDNGFTMNSYMPNILQSLAYMGGFYYDGNTTAQNCNNMPEGAVCYVPWAGGSIPVASMLLYIQAIAFSIQFVLFTTFGSLGDYGRWNKWILLSATIIGCASQIIPMVWVNNDGSQWNGMMGMMCIALISYGASLVFYAAAFPLLADNLPVVRKARFDPNVSREDYVLVAEKWRNNVSAISTTFSNVGFLIVTAVLSGASFAPWEKYDFPDGVAHILGNAPIFNYIATVFCGGFWIINAIPYFLWVPAGRGGPQLPPGENHLTIGWKNIISSLREARKLRYLFMYIIAYFIFSDAVNTLNSMIGIIQGQITSFNGTQITILNLVSAVCSIIGCLAFLWIQRWFKIRTKTNLLIIIVLTAIVPIWGSIGIGSTKFGIHNTWELWVFYVWSGIFIAPIWAWQQTMLAELVPKGKENLFFGLFGVVNKASSWIGPVVIGAITQSTSNLWEGWPFVLGLFLIAIVIIFFIDVDKAKEDIRLYLLENSDEASVNGQEKSIHSVHDTDRPVSAKDEKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFW5</accession>
    <name>A0A8H7PFW5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Succinate/fumarate mitochondrial transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_004581</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFW5"/>
    <dbReference type="OrthoDB" id="204711at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005469">
        <property type="term" value="F:succinate:fumarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000021">
        <property type="entry name" value="SFC1p Mitochondrial succinate-fumarate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF2">
        <property type="entry name" value="SUCCINATE_FUMARATE MITOCHONDRIAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="10"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="113"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="214"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2173207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="35709" checksum="8071296B8C8C9C29" modified="2022-01-19" version="1">MSKASDTKPKTLITHLVAGGSAGLVEACTCHPLDTIKVRMQLSKSGSRGTGGKRLGFFGVGAKIVKNESVWALYKGLGAVVSGIVPKMAIRFSSFEYYKSAMADAETHRVSTKATFLAGLGAGITEAVMVVTPMDVIKIRLQAQRHSMADPMDIPKYRNAGHAAYTIVKEEGVSALYKGVSLTALRQATNQAVNFTAYQEFKKACQAYQKLDELPSYQHLVLGGVSGAMGPMSNAPIDTIKTRIQKSNEPGSGWHRFKTVTTEIYAKEGWRAFYKGLTPRLLRVAPGQAVTFMVYEKVRSWLDQFNEKMDKGHGPIQAVIKVVEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGJ2</accession>
    <name>A0A8H7PGJ2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_000256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGJ2"/>
    <dbReference type="OrthoDB" id="2405944at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053226">
        <property type="entry name" value="Pyrrolopyrazine_biosynth_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419:SF1">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19798">
        <property type="entry name" value="Sulfotransfer_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2172906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="271" mass="31685" checksum="3F974B7E8341C008" modified="2022-01-19" version="1">MSPATTQAAAATKEATIMLWTHPRSRSTAFERVFIHREDIQCFHEPYGDSYYYGQTRVSKRFDDEHCKAHQHSNATYESVTQELLTGTQGKRVFAKDMAYYLYDSETRKLQIPKDTLTKMYHTFLIRTPEKSIPSYYRLCKGDTTTFDHFDPSESGYTELRWFFDLIREQTGVTPIVLDAEELVKHPKELMQKYCEAIDLDFSPDMLEWQPATVKQFDKWTGWHEEVQQSTGFGQYANANKQDDEMPAIVLDTIKANMPDFEYLQQFALKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGR5</accession>
    <name>A0A8H7PGR5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transaldolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGR5"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="37360" checksum="A5E148C0A31E169C" modified="2022-01-19" version="1">MSPTALDLIRERCELYQDTLDWRSVAHFKPIDATSNPFIVSANLEVAHNQQFVDDAAKYAKAQGGSLEEQVNLAVLKTMVNLGTAAKPYLSGRVHTQLDARIAYNTEAMVKQALKLVDLYQEAGLDKSQIAFKIPTTFQGIQACRVLEKEHGVCCNMTVLFCLQQAAASAEAGASYVSPYLNLLGRADGDPATGLANAHQIRVYYDAHGIKTKVLGASFRTVEHAEQMSVVADAVTINAVMLEELNKKAPTKLEPLPKIDSKLETTHLYTVIPFDSCANHEFIAEFLAPTSGPWLNNEGGYQWAMTMDERSCAGLVEGLRFFAAYNEQLDAKLLAKLKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHV5</accession>
    <name>A0A8H7PHV5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHV5"/>
    <dbReference type="OrthoDB" id="77989at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF44">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="32"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2174258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="373" mass="41923" checksum="86E1519BD25A76DD" modified="2022-01-19" version="1">MSPANLPQDSLYRLCSNLSSSNRTVHKIAGETRRACVAIIIRWRRGQYDRTPIDPNYRPRNWMDFMHDKMVQRDGGYPEILFIRRAKRAGDPWSGDMAFPGGRNEEGENDLDTVVREVQEEVGLDLNSNDFVKLGCLDDREITSLLGGKPFMILSTFGNYLNLDGASCRSISRHFYLQVSSESPQITRQNSEVAGTHWIPLHHFLYSRIKTAKPVKLPVLPLSSKLPSFFGTVALPSMLVPVKEETIVLWGLALTMTSELVSYTQTTKEIARHGQVAPLVRMIKAYPKLSQWDLNGFVRLFCFANSTWRVLKGEKQDYQTNISTSWAGGPSIPDYFASVRRALYVATAVRATAGLATGGYLAHKIIKSAYGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PID2</accession>
    <name>A0A8H7PID2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1446-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_005226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PID2"/>
    <dbReference type="OrthoDB" id="10265871at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056362">
        <property type="entry name" value="AtuA-like_ferredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47708">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47708:SF2">
        <property type="entry name" value="SI:CH73-132F6.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23544">
        <property type="entry name" value="AtuA_ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="1">
        <location>
            <begin position="9"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="AtuA-like ferredoxin-fold" evidence="2">
        <location>
            <begin position="523"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2173806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="636" mass="67968" checksum="BF411959DA17D5DC" modified="2022-01-19" version="1">MVDSSAKPVRIGCYSAFWGDSAAAALQLVEQEGSNLDYLVADYLAEVTMGILARRRKRSTKLGGSGAGGYVAEFITLVLNRIMPQLLENDTKIITNAGGLDPVACKLAIEAALTKAGIPLDKCKVAAVCGDDLVSESTATLGSHPDIRAFSATSNDDTDVLPKPDTPLSSLNAYLGANAIAKALASGAHIIVTGRVVDSALVVGPLIHEYGWTPKQQNYYDLLASASLAGHIIECGCQTTGGNFTDWKLAAFSEHGGYANMGYPIVEFHKNGQFVVTKPEKTGGLVTVATVGEQMVYEILDPGAYLLPDVILDMRGVELKQLEKNRVLVTGAKGRKPTKYLKCSGVWVDGHKIAGELLIGGEDAREKALAVGNAIVTRARTLLQAFGLEEFRGVNIETLGAEGTYGPHSTMTKSREVVLRLTVHHDNPMALRLFGMEVAPSATCMAPGITGAGAGRPAPMSNLVHFSCLIPKAKVPTYLCVGENGELEKLEWDSWDDSDNYVTPNSSMPYNDTQVETQGLTTVKLIKLANGRSGDKGDVCNIGILARDPQYLPYIKKALTEQVVSKYMEHLCKGNVTRYELPGTHALNFVLTKSLGGGGLSSLHIDRQGKTYAQMVLTGVDIEIPAKLLKSADSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJH8</accession>
    <name>A0A8H7PJH8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_005962</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJH8"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000028">
        <property type="entry name" value="DnaJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44924">
        <property type="entry name" value="DNAJ SUBFAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44924:SF1">
        <property type="entry name" value="DNAJ SUBFAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="89"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2174900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="451" mass="50634" checksum="EB6C1D5075C2C626" modified="2022-01-19" version="1">MAEIVIESRKPEPYVKSTCKDCITPIEFLSTSTNANKKVKVKCWACNKTSSYELDNTGLNIKNASKPSSSTQKKSYSRKGTDENPVSTTYYDLLDVSVTATQEEIKKSYRKMAIKFHPDKNRDDPSAEERFKEISEAYQILSDPKLRKRYNENGAENGVKPEGGFVDPEEFFKQSFGGDRFVDIIGEISIGRDMRDAIETAENDGDGNEADLSPEEKAERTAQKEVAEKERAETRQKRVDTLVEKLVYKLSLYTELPDTSPTSVAAFTNIVQIEAEDLKYESYGIELLHAIGFTYTMKANQYLSRGNIFGLGGVFHSVREKGYIFSETMGTLRSALDLQNSFSELQKADAKGLTEEEKNKLEEEAAQKGLKAIWRGSKLEVESVLRDVCDFVLSDTKASKELIQQRATALKIIGTVYQNVRPDVTPEDIHIEAREKETTNKSKENASASTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJU7</accession>
    <name>A0A8H7PJU7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2175045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJU7"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053144">
        <property type="entry name" value="Acetyltransferase_Butenolide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43233">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43233:SF1">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="169" mass="19763" checksum="961677257074BA80" modified="2022-01-19" version="1">MNIEYKCIEGKKDSLGMPCYESQHDTVVVSTDASRTDMDFVERSLKLSYWAGTRPKELVRRTWSHSLQFGIYEQSSGTQIAMMRVLTDYGHYAHCFDVWVDPEHRGKGYSKLLMSFYMNYPELKDVNRFQLTTSDAHTLYGQYGFAQLKEPEKFMEMKRHVVFKPSVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PL29</accession>
    <name>A0A8H7PL29_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_001352</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PL29"/>
    <dbReference type="OrthoDB" id="241990at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031567">
        <property type="entry name" value="CRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008828">
        <property type="entry name" value="Sin1/Avo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031313">
        <property type="entry name" value="Sin1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056385">
        <property type="entry name" value="UBL_AVO1/Sin1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335:SF1">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16978">
        <property type="entry name" value="CRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16979">
        <property type="entry name" value="SIN1_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23164">
        <property type="entry name" value="UBL_AVO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIM" evidence="3">
        <location>
            <begin position="311"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="AVO1/Sin1 ubiquitin-like" evidence="5">
        <location>
            <begin position="558"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="SIN1-type PH" evidence="4">
        <location>
            <begin position="688"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2175705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="793" mass="87535" checksum="D3716EB1B8D0B51B" modified="2022-01-19" version="1">MSLITDPNYLVHQMRIKFLRTDERGERLISFSPNVMSNDYIRTAAPIYPEMHLCYSPVYDNPLLMGAGNLINSPRTIRTGLRTRKKDMPPPSNPTNAQPATITAAVDDTKASVDSTEDYETEENDIISRKELLSGDSQQKRISVKRFFAPAVLVTGASQTGSVRKQRQSIDSITPAVSSADIAANNQVLSPDIGNVTSEDGSNMVFSTSLMEPSIYSPIDTSLNSSGDLAQKSSDINGRRNVPTDITMKKSRRRSTLVAQQPPVNIAQQLVASPAPDDKDLGSLLPGAEDPSPLIYDRQSLPVRPAFTTRTSTLTAMIEEKGKAAENPFAEDYSFVSGKGETNPTTLCVYLPFSATPDEPVNVVVRSDALVEEVIGFLLYQYIEQKKTPKLEQEMCDVVRWVLRIAEEDGEIEEDLPAVDRARRINRISFDQFALCEATPSQVKQNEQTHAKLAKNKPKKEPTTSLFVPSTPAPDTVHYIEQQTAPVDQPVMTNNQSSAPAVADGVDNTNLKPVAASAPANEHTSSADVAVPVPSQKNMLTKSTMTMAPTQHFRIRLMTNEEVSATTTLPVHAQMFMGDVLELVCRKRKLDTNEYILTFADYNMIVPNDTTVESLSGIIDLCLVKKSAATGMHVASSSHMWRSPSKKKKEDLYPAGLFSSNTSNPSTNESSMSSYKVGNILLMYTGTRYTVNRKMPMFVGKRESVLAIDGDYVHIMPPEKTGMFDSVKTTSFHVSQVLSCKQSKKAPSNFKVVVLKERDHDHKTYELEAESAKDAREICSRIHFLMQVSRATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLE6</accession>
    <name>A0A8H7PLE6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_005381</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLE6"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13994">
        <property type="entry name" value="STKc_HAL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF137">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="297"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="118"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="604"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2176148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="641" mass="71350" checksum="D9F7DAA78C739856" modified="2022-01-19" version="1">MADIQMAQDVNKHLADAADMLNPCFATLNFDSPPKVLQQLPLHHQHFEPITPDGSVPNSPTFAKSHLDFGVLSPGPLSPNDISLGYEAAEPVFPRPHQSHHHQQRPRSQLIHAHSYLDEKESSDDQQPTKRPSSYSPPSMSPRETGYQQSIASSFSTSKRESSSPRQSCQPPLRESDTPPFFSRPSSPSSSLGSADSTSAKPLTIRPPTPSQFIFKKPEYNLHYQSTHYHHSESAPKSPGLFNELRRFFGGLDTVTSRDGAESVCSDDAASIKTTNSRSSELSFANKFNDNLEGKYGKWGRFIGKGAGGSVRLIRRSADQKTFAVKQFRKRHPTESEKEYVKKVTAEFCIGSTLHHSNVIETLDIIQEGMSFYEIMEYAPNDLFSVVMSGMMSREEIACCWRQVLSGVEYIHSMGIAHRDLKLDNLVIDGMGIVKLIDFGCSCVFRYPFETKVTMSKGICGSDPYIAPEQYTQPCYDARLNDLWSCAIIFVCMSIRRFPWRIPRPTHDAAFKSFVSPSGQGAYRLLKLLPREARNIIGKILQVDPTKRCTLEEVLQDPWVADIDSCTLEVPGERHIHHVIVPPGQDGIKRGNIVTIAAEAPGAVADKEKRKQQVASGASSPVRPPMGPRRQSGYVAKPVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLM5</accession>
    <name>A0A8H7PLM5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_005502</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLM5"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016278">
        <property type="entry name" value="DUSP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000941">
        <property type="entry name" value="DUSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="65"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="5">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000941-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2176268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="330" mass="37348" checksum="1A66D519C8AE7172" modified="2022-01-19" version="1">MSDEPGQEIIPHVWVGSYGSITSKHFLETNKIQNVISVCPCDDTLTGYNQMVVSILDVAEENIMKHFPDCNQFIQSSIDKSQNVLVHCEAGMSRSVTIVAAYLMWKRQISPKEAITIIKQAWPSASPNSGFFSQLELYHEIDYTVDQTRTEYRRYLMANMAEEREMHGYVAEMTLAADPEFHNSSSYSLRCKKCRRVLVDKDNIIEHEPGKGQQAFSYHKRDSSLNITETASGDQGEINTSANVNASLNPLLASLASSKNNCSSYFIEPMEWISNLDQWSIEGRLDCPRCNTKLGSYCWSGAQCSCGRWVTPAFTLHRKQVDEMKAVRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLZ4</accession>
    <name>A0A8H7PLZ4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_005600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFG1/PHD1/stuA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLZ4"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029790">
        <property type="entry name" value="EFG1/Phd1/StuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792:SF1">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="6">
        <location>
            <begin position="84"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="255"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2176366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="506" mass="56521" checksum="DB3B3B04C91B2CA4" modified="2022-01-19" version="1">MYRHHPVERPSSPPPLGDPTGSYPWHQPPQPSSSQHQGSPSEPSSVNGSPTPTQQQMFMPPTNDSYQPFPVHHSYHPQVAPRPKLTTTLWEDEGTLCYQVDAKGICVARRQDNDMVNGTKLLNVAGMSRGKRDGILKNEKGRVVVKVGAMHLKGVWITFARAKTLAVQYKIADALYPLFVDDPSIFLYSTNGGPSRVTAMSGAFRPFGAFNATAQSPSALPAPSQGNWDRQADYLNRVSTSQGFRPPVYTHHDLPSNENNLYLENNASPDYRNNDNTIGGMVGHSQQQYGQLYHQYQQQQQSPDSPFVDQSRYTHQRENSQDMMGEQRRRNFSNNIFRPPPPQQRHVDDIPFTSPIHMPQGKATQYDSTTGGGVYEEHVLDNAASSRTSSPGSRHQNAPYQQAVRLISPSAVTMSPPTPQADIPSHYFKDPSTSPYLPRRESAVFDTPQRVASPRHHPYAPKPSGKVVFQQSPSNRLDQKNLSEELIEQTPTSLSTHTLMENHPTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMJ1</accession>
    <name>A0A8H7PMJ1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_005710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMJ1"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2176470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="377" mass="41303" checksum="88E3BE523E6B6639" modified="2022-01-19" version="1">MYGIHGILSSLSPFNINYFILFYLFSFILSAGQSSDACAFVPIDDTYNVGLHVAGVFIILVTSSIGIFTAIFLGTHDKFGKNPLVIGAIQLLKFFGVGVVVSTAWIHLLADAYSNFLNPCLVGDAWVNYGANFPGWIAIAASLTVQILEYFAMSREYRLIDRRQNELPQTNGYKVDETDNGLQTSNKSAHGGAENDVTLKEVVGHNLLDEDESPQMQASRNIGTVMLECGVIFHSVVIGLALGTIVDGWGTLLAAIVFHQLFEGMALGTRIAATSYSKMMKFFGMGIFYPLTTPFGIALGIGIRYTYNENSQTAILIQGFLDSAAGGILMYNGYVELVAVEMNHNPRFHRYSGLWKFWLYVAFILGLAAMSIIGLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PN45</accession>
    <name>A0A8H7PN45_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_007635</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PN45"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="186"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="216"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2176981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="275" mass="29393" checksum="75670F247659279F" modified="2022-01-19" version="1">MSGTPTLKIKLRLNGPSNKSPSASPKIDASDTKPSPASSAVSSGTKREASEPAQQATPKRSRGGPGSRSKKPVDSAASTPQPKATADLAADTDDAKSEVRTSRAGTPSRQQDSLAAQFAAIKDQKPRKWDRQKVVFKNLAGGNVEIYSWASDTAMQMNTTKTEPTTAAEIDALFSATVNERDFRPFLCTQPGCNKSFTSFDQLQTHETNMHGTKNMVCGIDGCTKGFATSGQLTKHRKMVHYRTSAKKKAATIAAKQAQKEKEDSIDIENAGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PN91</accession>
    <name>A0A8H7PN91_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PN91"/>
    <dbReference type="OrthoDB" id="2398617at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="242" mass="26326" checksum="6047D7B12BF1012F" modified="2022-01-19" version="1" fragment="single">SLTSFSFSSTVMRFYPPRSRLSVLAALLCMAAAVLVFLCLYSCSTSSMMRIYFLKFTSGSISVYYGWRYHCIIDSGATNCVYDNIVKYPLDLFSATLFNTTYPQIFANQVSLDSGTQPLFEATPLHNPQIVAAGFLCLICSLSAALIVILRLTTRKIVDRGQARGFLTLCGAALAMMMLALVSMLYDSGEQILNLEFPNIHAEVGNGKSLVGITFGLLFVAAAILLRGCLDDSSSDAGYSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PN98</accession>
    <name>A0A8H7PN98_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DC-UbP/UBTD2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PN98"/>
    <dbReference type="OrthoDB" id="1640476at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.225.20">
        <property type="entry name" value="Ub domain-containing protein, DC-UbP/UBTD2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032752">
        <property type="entry name" value="DC-UbP/UBTD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038169">
        <property type="entry name" value="DC-UbP/UBTD2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039869">
        <property type="entry name" value="UBTD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13609">
        <property type="entry name" value="UBIQUITIN DOMAIN CONTAINING 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16455">
        <property type="entry name" value="UBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DC-UbP/UBTD2 N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="271" mass="29890" checksum="CDCC46A74217689B" modified="2022-01-19" version="1">MGCCSSSEANSDEGGYASRNRGFRAGNKPFKRKGIKWTANPPITEDQLQQQRDTFWDTAPSYEGRPEIWQALKAATTEMDVSLAQSILDAAGITMPTGNPADGCYDELGNEYTVPIYCLVDPTNLLPAPTVSSGTHMASTSQAYCNQETYSPPLQKLSDKDADNSTPADEKQIINSGSYPITIRLSTSIDINTKIATDGSDNIGKLRSRLMELPELAFARESHYLKFIYLGRILDDHVRLYDEDSKIENDRNNAKIPKNGVLQALVAKKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNK0</accession>
    <name>A0A8H7PNK0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-galactose transporter homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_007878</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNK0"/>
    <dbReference type="OrthoDB" id="1601at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2177221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="365" mass="40437" checksum="5CF88DC25E7BB4E5" modified="2022-01-19" version="1">MLQFTLCVIGIYACFLTWGVVQERVSTTPYGTAEAPNKFKYFVVLNLIQSIFAALVAFVYLKLSGKNTNFSSSPNSLLFKYVQVGFLSCIGSPFGYAALKHIDYPTMILGKSCKLVPVMLMNVILYRRKFALHKYICVAMITAGVSMFMLYHSVEAKKGAAANSLWGLFLLTMNLVVDGVINATQDQVFHSYKGLASGQHMMFYMNAIASLLSAGYLIFNPYNDEIWRAIEFCSTHPAVIRDIALFGLCGAIGQCFIFYSLERYGSLRLVTVTVTRKLFTMLLSVVWFKHVLNPGQWYGVALVFLSIGLEAYIKMNGSKSKDAAAPKKAHSSQHAKAHNGLSALNSQTLRGGHYNYPLSSVDKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNM7</accession>
    <name>A0A8H7PNM7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNM7"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="128" mass="13826" checksum="EBE083AA487B703D" modified="2022-01-19" version="1">MITIVTPADAPGPKAIRNSNECIFLGCQFLIEDMDVYRIHLANEHGKITGRSVIFTETSKTHAHSVSKEKSTSEEESASEAANADDLEAVLQSSRLNSTPSRLSVTSSTSSESNINDLLTNSTLLSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPA8</accession>
    <name>A0A8H7PPA8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_007735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPA8"/>
    <dbReference type="OrthoDB" id="432299at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000001">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="81"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2177079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="159" mass="17944" checksum="6187E7CB4436ECBD" modified="2022-01-19" version="1">MSDSQHLTPNNVTPTMVLSDTDANVMEVPEFPARNGPQRLVAAATPQPKRRQKVKLEPGHSPLDWARLKSSGKNLRGVTELKRYTLDEVREHRTQDDAWTVLNGKVYNMSAYVNFHPGGVKDVMRIAGRDGTKLFMMTHSWVNYEFMLDACLVGFLTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPN2</accession>
    <name>A0A8H7PPN2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="8">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_007916</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="8"/>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPN2"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF12">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TYROSINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="9">
        <location>
            <begin position="67"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2177259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="382" mass="41830" checksum="FA3739BB96054AE9" modified="2022-01-19" version="1">MTVTQSLPVSHVNDSQVDQLKNKSSVHPEFMEDLRVSSYNALLTPAYVHEEFPMSQKAKETVWMGRQICADILRKKDDRLIVIVGPCSIHDIDAGLEYCRRLKLVADRLGGELLIMMRTYFEKPRTTVGWKGLINDPDINGSFNINKGLRIARGFLCQVTDYGMPVASELLDTISPQYLADLISWAAIGARTTESQLHRELASGVSFPLGFKNGTDGNINIAVDAIRAAAAPHHFLGVANNGTLALTNTKGNSHCHVILRGGNDGPNYEQKYIEQTRTQLNKAKLPLNIMVDCSHGNSSKKHTNQPIVSSNLAQQIAGGDGTICGLMIESNIHGGRQDVPAEGIMACKYGVSITDACVDWDCTVDMLEELAQAVKARRATKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPX2</accession>
    <name>A0A8H7PPX2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_003527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPX2"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2178274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="69" mass="8022" checksum="DD7FCD4449B118E0" modified="2022-01-19" version="1">MFPKDFPSLDQTQIFLAEKDRIIHAPRVYKYLKNNNVSAVMFEGYGHADALLVHTKEQDRMVQAIIKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRF2</accession>
    <name>A0A8H7PRF2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRF2"/>
    <dbReference type="OrthoDB" id="5587891at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2178818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="321" mass="35990" checksum="A9F66DA8B814A3EB" modified="2022-01-19" version="1">MSTANNYTSTLSPDMVSAINTNNWTLTYLSICLTCSIWQITNSLNLTWIARKPVHGVVLFQSFISFLSILFSLLNPLTRLNCDARYWVSIVTVNLGGICIQSVLLYKAYVCNERARWLLGIGALAQCGYMVLIFLDATAGRVTSTQDPLTGMCQLENKNWPALAKIGVDLLSNAILSFAFFRVIFRQYRVFGNSLYKSLLSNSIIFSIGVILSNLIVGILIATRVIGSLSSDLYAFDWVVTSYLLIKQFRRDHHQPKATRNSYDLPGFNYRINDDLQVTSLPVISYNAQLARTPTCSHCEKCQHRLRSDDSLPTSSFYPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRM7</accession>
    <name>A0A8H7PRM7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_001871</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2359410at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00243">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="154"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="GAR" evidence="7">
        <location>
            <begin position="2776"/>
            <end position="2850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2724"/>
            <end position="2777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2869"/>
            <end position="2909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2933"/>
            <end position="2955"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="595"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1434"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1910"/>
            <end position="1937"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="2095"/>
            <end position="2122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="2190"/>
            <end position="2217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2727"/>
            <end position="2738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2869"/>
            <end position="2890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2894"/>
            <end position="2909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2934"/>
            <end position="2945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2946"/>
            <end position="2955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2179022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2955" mass="336611" checksum="2738626F497A79C2" modified="2022-01-19" version="1">MLKKADTASVTPAPPLWFPHTNTVDVVPANDDHLLMTWVVQQIGSLESVDAVTLRNLVTQDSVLTRLLSSVTILKAGQNDCGSDQAFEMARQWLNKDMPDIQTTSISDVSSEKVAEFVLAMLLKHLCEALERALRQTKVWTFIDQSTLSDTSYHKIRQLLCSWYQTITLEYLPVCSWMEDGNDFLTSWKTGAILLLILHYSDPNCVELECAQEARLATSQSNMRSNVSNALNIALKRFGVKRRLTESNVIHAENCEISTIIYLCELCIATVSHADDFRDSRQKQIFDKCHQAVNEVDDLARVSDLTIVETPDSAPPDIVVTLDNLEDYAINIRQMVSILRVKMDDCVPRRSIAFRREDPTLGWMRDRAATPSTFSEASGASASVDDDDTASLQSTRTVHPLQAMDEDKGSYKMTLDNTIHAIQAYRKHDINKFYAAAHELQISAPSSKQRVLGLVNSIDELDQTLEQDIIIATDAFQLFDRGYGFSKQAKSIRFELDFIQAKMVKTTTTNTGITELENRAQHAYEDIGQLEQSFDDLLDADSTDQSYRNILESLVQKYELVQAWVEEVRIWFAEAERIRNWIESRIQMLEEKEVEDSLAEKINTTQTEVAKLNDDHEALEHEIESFNKEDMTRLRAHVKALTGSEKGDKDLSPADTTTIEITLTTLMTLDRLMHLLRQKTHTLQVLSIRVLWEAEYATATKWVEDGHAQTTLFVIEEARWRADTDMRTVSNDGSEQFLPRDDSIELRTQVINSLLALEHSIADFDQGQFTSTLEIFQDFEDIIGDDKPQHLESRQAGLEASFQTLTSRVQFARKVVEQRLTMMEFIQQYVLVRTEGQLILHDLENMIATITYTMQSTDNIQRVQTFRNNLTHLTGFVAGLVTYPPHNCEMDEASNDRSNDEIFDFLEARNSELEDLYGTMFSMLDKLGQLIQDHKEAHAIQLGLQLMNDQLSESQSELLRSPIDIAVKKLKLTENDVKKWNEKQNDRITHFEISKDTEFDSLKIRLEKLSSSCDRQTCTIDFAFLDNEVSRLTIKFDEFSDALNHQNLLLEALNHRLNWETSFSTASQQISEHFFKIMEYAKMSRWYPTEETRVNKEDISNIAKWKQTITDSEQQMKAFQNDTLMPAARLATILLASIHTIELKSNIQTDQSFVASVQQQQSELAEKFEDLYSALDYHRALVEQKNIILELLRETEKFEDTGMSCLDQMKRLIEHGLQHRYVDFSGQIKEFSRDVEELFTNRIAKLPPIQCSQLKHLTSLSNDNDRETNTAIGAFFDSRKEEVQKLISEMKDMQSKYIVTQELKSKVSQYEQDAANLCHWILLQSESLAECKQELKCIAQTLDHDRLDTLINLQNERYEQVDGYARKELDNLSANISELATSIAEVNACNVDMSPASSTYDLAVADMAILIHAMEGHGRNIDARKQHLVLQQLLSDSQNEANKFQIQITELSNQLDTLTQNDESGVFHQTTVLSISKQCEDIDVELIAFDNRVGAEIRSSLSDLERLCSQLLEPVAPPADLSNRIIEFDDGYIRLRENTSSLRARIQVVMDFKNCLEKADSIYAWYHEQEDVMERFLADTARWNPATGSAQVNINQISEGIDSIKISVDIYESQHIEPCLVALDEIKTSIAETSFVNLIDRLEIAKTSLQGGIQKLHDHIAFGETIIAQNRSATWYLARVNEMQMQAEAIRANLIEHKNDSTYQLDDLNVLEAQMPVTLQESNMRITYPVRSFDGFRNEGAEKDVKTNELLSETVRERNHQLQQIMANIKEIVHLNDVRMKQYYLVQQYSEQADSLKLWISDQTSNLQRVMNTSADATLDETKALLANIHTVSKDLEAHQSTYEELKARSLETTRLLLMQGASDEGSREADVAALADSIDQAQRGIDNSWDTMTDDCIKAIVRLEADFDAKQLGESLQELLKQLGVLNEDISAAEEDTSNEMANDWTDRLATLLSQPLASLKEQDELLKLKRKECDIPSYEKNELLFNQIDQQIVDVNADIEKLAEIRYQNELLENHLRNGSQLINDVNEINCMLTPTITSLWHLTGDDTVDSATQVSMNTIMKEVQSRFTILEQKCAKYCDSSLSTHESPIQQKSDLEKALSNFNNQILQAQKIAQDYENAFAQQKMFNNVMLERLPKLDNVLRDASVTDSDLTNVTQDLGAVREILQEYETIQSSLVGMAEPQNEINCQQLEACYAEIRANLERREAEVLELKTKSYKAAPLAEFQRACTRLRDLCKEQSRLLNNTMEATGKSQFYIKDITFLERLLRQNISIHSNVERELKLLRSQTDVQSAELEQLDAGPELHTYLEGAREELEQLQTILDTDQKQIDFVRKIFAFAKASSQIYAWMEGCKRAIRGIDTDSLNENEQQSDLTDLSIKMNGFEPTMTAFNNMVSAILKDKNDEPVDLSEIQMKSEDVSAAVNMRSGRVLGEWDALKKQYALLQWNSESSIQGTTIARKSKEIMALVDKIKSHLRSLSVTRVALETPVIVCNIPLLDLLSEREVIVVETQMNNLEREVEYQLNKKIDALDQIIALSTTLQDGTFVQQRAHIAQVVNELVNMMQEKHQEITVALKIAGFVGKADEVEVLLSAIQETVDPCVAQTKTERLQSKADLQALLIELDARFKYYGPRIREKLEETKDMAHTFEDNERVTQKFTDIEKRWNGLREQANQAKLYLTSKIAGLSATTPSPRYMDHQGPPRPHSVADVRTRKISEKTIARAMTPNPRSSTSSQMSTRGLGKLDSPVTRMRRATHTPMTSRSGKAASVPPRYIPDPKSDLDVQLGKVVNESPYKIRIKMVPGEVGKYWFGDIEPRLVYCRILRSNMVMVRVGGGWTELSQFLRDHALLEGRLIPNRFEEEKRVNVRDAYLRTKPKPKDVNTQEDLKKSGSDPIKSSRSAPNRATNNAVNQAGIKEGNRFLMTVDGQGNQLEISMKKATDHEPRLHTSTPRRSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRN8</accession>
    <name>A0A8H7PRN8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Aurora kinase</fullName>
            <ecNumber evidence="1 15">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">INT43_001717</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1 15"/>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRN8"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044779">
        <property type="term" value="P:meiotic spindle checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902115">
        <property type="term" value="P:regulation of organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072479">
        <property type="term" value="P:response to mitotic cell cycle spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="118"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11 13">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="196"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="245"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="12">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2178871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="382" mass="44173" checksum="061FC64C71BF436F" modified="2022-01-19" version="1">MNIVHSVETPVKRKDSSAFRVADNDNFHTPLRPTPSSHIPTVSQSAYVDYTPRRLIPTSTPARGPHAQTFMDSPMIRKQAGVSPHIKHISPEPVMQQEEREINMLKSQRTGSWCIDDFDVGQHIGTGQFGRAYMAQEKKSKHVVALKILQKEEIQMAQVVSYLKREIEIHGHLRHPNILRLYGYFHDDQHVYMVLEYASNGDLYQLLRQKNRLSERQAALYIAQIAAGLLYLHNLNVTHRDIKPENILIGREGVLKLADFGWAVHDPNPKRRTFCGTLDYLPPEMVESQPHDHKVDVWSLGVLCYELLVGTPPFEDLDEGYTVTYEKILNVQYTFPSYVSELAQKFVQKLLKKKPNDRLPLSEIHHDPWIRKYMVNEQNRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PS44</accession>
    <name>A0A8H7PS44_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">KpsF/GutQ family sugar-phosphate isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_002043</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIS family. GutQ/KpsF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PS44"/>
    <dbReference type="OrthoDB" id="1872003at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05014">
        <property type="entry name" value="SIS_Kpsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004800">
        <property type="entry name" value="KdsD/KpsF-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035474">
        <property type="entry name" value="SIS_Kpsf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00393">
        <property type="entry name" value="kpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38418">
        <property type="entry name" value="SUGAR ISOMERASE, KPSF/GUTQ (AFU_ORTHOLOGUE AFUA_6G08860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38418:SF2">
        <property type="entry name" value="SUGAR ISOMERASE, KPSF_GUTQ (AFU_ORTHOLOGUE AFUA_6G08860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SIS" evidence="6">
        <location>
            <begin position="44"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="312"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2179193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="39358" checksum="B32F7DFF7CCC2BF3" modified="2022-01-19" version="1">MDNMAIEAARILRAEAQALLDAANRLDEEASSARDGYNTAIYYLRQSLDCGGKIVITGVGKSGKIGEKMVATLQSTGSCAVFLHPIEALHGDLGLIQENDCILALSYSGNTDELLQIIPSLRHRRVPIIGLGGNAKSKLAKECNAWIDGHVNSEASSEIPAPTSSTTLALAIGDSLALTLAQQKKFQKADFALNHPGGALGKRLLLKVKDIMVRASQVATVEPSAPLDVVITEMTKNPKGRGVIVMEPMSPPATPPLTSEDITNRGSLERALLEAKPLTGQCKILGIITTGDVRRALAFRERIFDICARDIMTLHPVTCQSDRLASEVLELIEAGSEDRNLSVLPVVDKCHQWRGVITKKDLESVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PS45</accession>
    <name>A0A8H7PS45_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">4-coumarate--CoA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_001762</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PS45"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="30"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="434"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2178915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="58777" checksum="09C65CBBE2BFFBF3" modified="2022-01-19" version="1">MVYVAEPLNLMPQVDLWTFLFSNPLNVSLDKPLMIDGLTGKQLTYGQVKSDSLKFRAGLDKFGFKRGKYNAIDYPTIAFGTVAAGGSMSPANPAYTAKELQYQLEQTKSKILIASQETLPVALDAAQLAGLPKSSVFVFGDNEISGVKPYTQVLMAETEMGPVRLNHEEASNTIAYLCFSSGTTGRSKGVMTSHMNIASNILQVFQHTQDDLNLSTERYMGVLPFYHIYGLTCMFHFCTYLGLPLVVLPRFDLATFCKSIETHKVTIAHIVPPIFILLAKDPSVTKYDLSSIRYFWSGAAPLSRELSHAVSNRLNVGAIQGYGMTESSPVSHVPHLRSEVSGSIGELLPGMRARVVDEEGKDVKQGERGELWMAGPNIMLGYLGMPEETAQTVDKDGYLHTGDIAVVDENNQWYIVDRVKELIKYKGFQVAPAELEALLLTSDLIADCAVIGVYDASQATELPRAYVKLTPGTPADDATAKAIEVFVEKNVAHHKKLRGGVRFIDEVPKSAAGKILRKELRAAANEELKTSVKSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSR1</accession>
    <name>A0A8H7PSR1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSR1"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="372" mass="42365" checksum="CA5E63BCE2A97D85" modified="2022-01-19" version="1">MHKPKVPPELLSLILENLDQIDLFTCTTVNRTFNAAATIVLWREPVLNSASVFYRFAASLARTKESKGKLVRVLDLHRSVNSLVTDDWLSDIIIWTPLLDTLCIPMCDQISDKSMVKLAKYCPELTYLDVSRSRITYRTCHHLRFCQKLRYLSLGATRDLSEFALLPFSNSRIDCLRLNDCPWVSVAQTAQDICSLHHLEDLDMINCRDVDDEFLLKLSIPDTDMKSFNPLPELVTFALSSSRSITDEGVMAFVRAHPKLESLTIYQSSITDRTINEIRVSLPNISFLDLSYCDNITSRAVRRLIADNHKLEMIGLKGCLKVRSFDFVELGNSDYHPGIDRLTSAEMDIIRTSELNRLTKAQQLESSMHDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PST2</accession>
    <name>A0A8H7PST2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PST2"/>
    <dbReference type="OrthoDB" id="680339at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051884">
        <property type="entry name" value="Bis(5'-adenosyl)-TPase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243:SF1">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="45"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2179879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="108" mass="12025" checksum="626A181B0130C376" modified="2022-01-19" version="1">MSSDEATDMILSAQKIGKVIEKVFNGTSLTLAMQDGAQAGQTVPHVHMHIIPRTADDWANNDEIYDELDGKKAATMGGVDSKDRKARTIDEMRVEAEMLRPFFDQQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PT59</accession>
    <name>A0A8H7PT59_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LMBR1-like membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_001632</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PT59"/>
    <dbReference type="OrthoDB" id="203099at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051584">
        <property type="entry name" value="GPCR-associated_LMBR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355:SF0">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="564"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="645"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="691"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="723"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2178786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="735" mass="81586" checksum="E28B3B1BBAF6D762" modified="2022-01-19" version="1">MKDVHIFVITAICAYLVILLLRTLWFCSLVQNGSFIELPAADSDYGGVSSASSVLHIILWSAQIATLILLLPDLRAAKVAARAIIPMLQAYVNAGNFTVGAKLRYAVSINLKFYLVYAIVAVVGLVYLIIGNGYTTRDKLQGYVMAMANSWGLLLAIIFMGYGLVAVPRKLWFAANAKKELRHLYVRAPRVKEECMDSELEYAEVAKAIRKVDQKVKADDIHLRHAVDLILRRFPSVSEVTSRDTFRSVSVPRQLTEQYLVDLNQRMIKAARMRDRKLALWNNLIRDAFYLQDVVANQDSLDHHFYSTVRPLSEGTTMQDLTIRLEWWWAVRIKPVLTRALAVVCAGIGICIIWSELTFNVRQPILSIVEITLRACGLNYAAVEHVVVYRISLQDDVSDLANSKDLQNNTVFNLVICRAPLCYNYLNIAGDSNESNTVDQSVFSRFMGHADLVPFLGTTFIDWFPVVILIPALTMLFNVQGRFLKLCGIPDIYEDDEGEGRHAEDEEGGLRGGHIVLNSEVDEGKALINEERRIREREVDPSSDNRAGGLLDRARNALGTYTAKYNRDQPTRAGNSHGHNSSSVRRDRDRHIDALLSGHTASGHRSPFLGSDAGSASPEDTTGELSDDSSNAFLRIKSRVGKGISELWNKGTPPQDISPPSGSAARGRALEPETARSLPTSSRVGRALRSRSPSPNPWENVTTGGTSMVRGGSAAPTFNTRNTKRDNRKNIFDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTD6</accession>
    <name>A0A8H7PTD6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003744</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTD6"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2179957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="178" mass="20479" checksum="EB13B848BED4E2F6" modified="2022-01-19" version="1">MAINLETLQVKAKQQLKDLDVELSKYKFFNDMEAKTKVQKTHIALGGAAILFVMVFFNLAGGLITNTIGWLYPAYASFKAIETPSTADDTQWLTYWTVFGFVQTIEYFVDVVLYWFPFWYTFKVIFFLWLALPQFRGAEFLYTRFLRPVLLKAQPNVDARLRTAGTEASNVINGAKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTF5</accession>
    <name>A0A8H7PTF5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_004028</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTF5"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF3">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="242"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="360"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="394"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="679"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="482"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="591"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="403"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="688"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2180239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="704" mass="78636" checksum="3DD0A19B6E06B871" modified="2022-01-19" version="1">MSNNIYSAVYSGVPVYEMMCRGIAVMRRRADSYMNATQILKVAGIDKGKRTKILEREVLIGEHEKVQGGYGKYQGTWIPFDKSRELAERYQVADLLAPMFDYDGQQGVNGTNEPLLTKEQHVAEERKKAQLASPMAPSPLAVPARSQTAFRRQSKDSIPKITKQNIEPKAQMADRPRREPSSVPIARIQRGQTADPQDRSGERHRNVLMAIFLNEDPTHIPELLMSQETPHDFNTELVIDDQGHAALHWASALARIKIVELLLNRGANVMRTNFAGETALMRACMVVNNYEQRSFERMLGLLEKSVPIADKSDKTILHHIALTSAIDGRQEAASYYLKCMLKLIRDRKELQGLLDVQDENGDTALNIAARGGSKELMEQLIAAGASDEMVNHNGIKPEDYNELDNNVTRDGSPQDNHETLFSSNRDTPGRSSSPINMNSVREMRTPDIIAEPSLTNYRPSSVPSKRGREIVSAVQKIVDELDSEFSEELESKQQEIDQIQQSLESTATELKESRAQLQQYKLERQRLAEAERKSTNLTEAVEVEKAKLADKLTSDHMDINIDMVVNNAVNDKVINQDPKGKAKPHEDMSKIQKLESSIVRLRAKITIYKKNELGLMAELAELETQSSDKEDQCKKLIAACCGVPIEKVDSLLHPLIQAIESDPPDLDLSRVAGFMAKIQSHDDRGESSSKAAAASIDSAMDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTG3</accession>
    <name>A0A8H7PTG3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosome recycling factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_003669</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTG3"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.20:FF:000001">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000001">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="7">
        <location>
            <begin position="111"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2179883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="275" mass="30373" checksum="56DA8A3AEF48D852" modified="2022-01-19" version="1">MSIQSTLTASSWRVARAALRPKVQTVAATRLIRPAIAIPTVCVPSLSMCGSLNQQSVRSYASKKAKGGKVSPKKAAKEAVESDRDDKDADVELKFDVDQLVKKMNQVTDWLKKDLANIRIGRANPALLEGVNVNIESSHAPLHHIAQITIKDPQTLLVILHEQEYLQPVEKAIREAGLNLNPISDGKNLKVPIPKPTKEHRDNMVKIANKAAEQAKVRIRSVRHDGMKDLKKDLKVGVSSDEIKKLEKSVQNNTDSHVKEIDDILKSKTKEITSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTL0</accession>
    <name>A0A8H7PTL0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_003890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTL0"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000182">
        <property type="entry name" value="MAP kinase kinase kinase mkh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF48">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BCK1_SLK1_SSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="684"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="352"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="464"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="506"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="715"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2180102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="969" mass="107483" checksum="A52D697B625D8155" modified="2022-01-19" version="1">MMLENGNMKQLPPSPSHNTTLEEQMSEWTQARVTLWLDANGWSQVSPIFEGSSSFALLLKAVGTENLASQGQYGTRPSPTSSRQPYNEYDTLRSNSSPEFSTFNETYSYGGTQSYRPRPRPTNNKLTTTFPPTINTNHTSPRSYGPRQFNRSESANTDYNRIKDIIPERTSSTPEHIYHILENLNYKLPQRRVPDTMERTAARNLQHLLGANSSTGQENGSYRQPSRRPVTQFQDKTSQQRIQVTADADTWFSLTVSDLHDPSSVKDAILTRLNISSHNGPYEFIHENGPYPDSALSDTDLLRLCRMADRSASNRILVRAPAHHNTSDIMASPVGGQFAIGTSDLWAVSPSSPVAQGSMNDNRANTLKPTTTAAPSLWAIQPKKSASSSLWATPPSSEPSPNATRVGSEESLWPVEGQATPSKPVSYWATPPSSSYQSKRASEELLSTSGGGNGNDLNSSGLDHSNTLESTVESLSLKSPRKEKNLQIQIPSSSSSHTEDLDTARSDYSSRQSPQYGSSTPTQHPRHSSSSESSIYFDGSKQETSQVQTKPSGKNEHVFWGERPPAEVITQNPDKYFDEQNLDKEIIEDIPNAPANSRQGGANLVPRKSVRIKIQETAKSRWPTVQNVFRANNIIRRQSTKMWGQKVVQVKPGMGIEQAAPAPAYINDEKTEVCSRPGPTKIRWMMGKLIGKGSYGRVYHAINLDTNPPEFIAVKQVEIPSTKSDLLNEQQRAAIEVLYHEISLLEGLDHENIVQYLGYDSDEAEGHLNIFLEYVAGGSVSSCLTKFGPFKEPLVSHITRQILQGLTYLHAKHILHRDIKGGNILVESDGTCKISDFGLSKLNDQDEVYDQNSKMSLQGSIFWMAPEVVKNQPYSAKVDIWSLGCTVIEMLTGKRPWLDLTALAAVYSLGTCKSPPIPDNISDYAKDFLRQCFIIDPAIRPTATILLQHPFCRVDPAFDFQNFVSPKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTT4</accession>
    <name>A0A8H7PTT4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mycophenolic acid acyl-glucuronide esterase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTT4"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052382">
        <property type="entry name" value="ABHD10_acyl-thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16138">
        <property type="entry name" value="MYCOPHENOLIC ACID ACYL-GLUCURONIDE ESTERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16138:SF7">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE ABHD10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="30096" checksum="1533FFAF6218EA1F" modified="2022-01-19" version="1">MAAIRMSDYLKTFTTRNLSKLQYYHHHQVSTKNYIAPTICFIPGFRSFAFQSTKPQYLQQFCLQENYSFLTWDHASQGTSVAADQDKVSVDLWFQDTLDILAAKVDGPMILIGSSMGAWISLLVATRGMASITQRLSGIIGIGAGINFTERWLNDEVPVKHPHYIWKRPSQYHESGSYEIPVRFLLNSRPCLLSENELSVTCPTVFVHGRLDMDSKLENIQNLAKRIPGSSVDVIENGDHRLSKAAELERIKLVIQQVINGSFSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUP5</accession>
    <name>A0A8H7PUP5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUP5"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="95"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2180899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="182" mass="19537" checksum="29076E5C5D8F7A59" modified="2022-01-19" version="1" fragment="single">ESSGTHSERQSKLRDYLAIYDPELDRAKPKTGNQVVYRFNGEVKPGDIPITPRDPRLSVLGYGKQTSKGRQKWVAALIPVQFEHDENSKGPAPPTSVLISHLSPLTTEAQIVTYFSIYGQVDKVAIEKSPVTGGSLGLATVTFTGPTSDAACSAAKMAVEKGNGRKIGAGSYVKVEFDVDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PV79</accession>
    <name>A0A8H7PV79_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PV79"/>
    <dbReference type="OrthoDB" id="4131217at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF66">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2181184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="31074" checksum="A41F6F6168929F56" modified="2022-01-19" version="1">MSSKSNTSPAPDRLAQIKAHIALDKPSMAGKVCIITGASSLYGIGRASAFAMAKQSPAAIYVTDLSTDNLEELANSIQSKYPSVKAFARKVDAASEDDVKSVIDEAMKAFGRLDVFFANAGVASGTHIKDETPESFMRMMKINALSAFLAIKHASTAMQVTGKGGKEQSGGSIIATASVAGIRSGAGSSEYSASKAAVINLAQTSSYQLARTNIRVNAVCPGLIETGMTKQTFDWARSRGNESKIGQLNPLARYGIAGEIASVVAFLASDDASYVNGQAWAVDGGLSSSHPIVPGKFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVA2</accession>
    <name>A0A8H7PVA2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008812</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVA2"/>
    <dbReference type="OrthoDB" id="1924287at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000004">
        <property type="entry name" value="pre-mRNA-splicing factor CWC22 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="7">
        <location>
            <begin position="414"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="370"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="615"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="626"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2181229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="678" mass="77503" checksum="D915D29BC79D00BC" modified="2022-01-19" version="1">MAEVAAARSVDSISRSRSRSRSGSPPRRNGSDRYRDRSPQRPQINDFDPVRRRERERQMQMQQEMNAVNPPSKRKVDPAEEMRIAQTTTKAGGAYIPPHKLRRMQQDITDKNSNEYQRITWEALKKSINGLINKVNTNNIKMIIPEVFGENLVRGRGLFCRSIMKAQSASLPFTPVYAALAAVINTKLPSLGELLLTRLVVQFRRAFKRNDKTVCLAVSTFIAHLTNQLVAHEILSLQILALLLERPTDDSVEIAVGFIREVGAHLAVVSPKPNNAIFDRFRAILHEGQIDKRTQYMIEVLFQARKEKFKDNVPISEDLDLVEEDDQITHYIGLDDEELDTQEMLNVFKFDPEYQENEEKYTAIKAEILGEGSDADDESGDSDEASEDESEDEEEMEVQQKLQIQDRTNADIIGLRKQIYLTIMSSVDFEECCHKLMKLNIQEGQEIELCNMIIECCSQERTYLKFYGLMGERFCKLNRTWGEAFIQCFSDLYETVHRYETNRLRNVAKYFGHLFSTDSLPWTCFSVIRLNEDETTSASRIFIKILFLEISETIGLKTLKERLKDPYMQESFQGMFPKDNPKHTRFAINYWTSIGLGGITDDLREWLRTAPKMIMRRQREEESSSDDSSGSGSSSGSDSSSSSSSGSDSDSGSDSRSGSGSDSYDSRSRSRTPPRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVD7</accession>
    <name>A0A8H7PVD7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubinuclein middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_008872</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVD7"/>
    <dbReference type="OrthoDB" id="5576775at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026947">
        <property type="entry name" value="UBN_middle_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21669">
        <property type="entry name" value="CAPZ-INTERACTING PROTEIN AND RELATED PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21669:SF28">
        <property type="entry name" value="YEMANUCLEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14075">
        <property type="entry name" value="UBN_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="3">
        <location>
            <begin position="116"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Ubinuclein middle" evidence="4">
        <location>
            <begin position="338"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2181289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="64723" checksum="1FD6ACD2846CF9F0" modified="2022-01-19" version="1">MATPESQADSPASTVDSPIKLAPSRTIRIHVNLKEKAPGTVISYAELLRKAVQPSKDDSSMDADAPPDSDIHAEKPPEPSKEDSFFQSLLARSAKYTLEEDDEDSSGPANRKKLPDNEYDVDDPFIDDSDMLLDDSYAYSSKKHDGFFVYHGPLEDEEEKKKASKKAAESRVTSKKLTVKKKGLADPSDQSHSETEGDGKTKSVKKSVTKKPVVKGTATSTQAKKRKPDAGEGSAKDDSQKKKKSKLEDPTASPSKKPDLAKKKPSAASDGVKNEDTVMTNGDAADKSAQAQDSEKDGGPTSHVASAGANASTTDAPQASPTPEPKMKKANKPVKLFPLDPQVEKIMQQLKEDAGKEDFAVKSKFPPNLRPTVLAAGSIVFRQQNCAEENFVNHLMAILPYNRFTLRKFLLKQLAPVRIEELQTEIDNMIPLLKQQVDEAMPVQLKQHAEQVAKAKEAKDGETQKGGTAEGEETNNDEKKEDNKDGGANAEGDQAATKFRFNEETRKTLYNIMQAEGARTNLKNDLSKILNSSQDQISETTARKQMYQRLMPCFPDGWMTTYDMSRQYSQYKVRLQKKEDKTAAATPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PW32</accession>
    <name>A0A8H7PW32_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008718</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the epsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PW32"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16991">
        <property type="entry name" value="ENTH_Ent1_Ent2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF110">
        <property type="entry name" value="EPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="7">
        <location>
            <begin position="17"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="353"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="496"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="353"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="432"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="535"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="597"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2181136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="633" mass="69925" checksum="F7F80CB9F2370AF3" modified="2022-01-19" version="1">MTDTPLSGKGVLRSVKNYAKGYSDIQIKVREATSNDTWGPSGALMNEIAQATHNPQDFLEIMDMIDKRLNDKGKNWRHVFKALTVLDYCLHVGSENVVLYAKENAYVVKTLREFQHIDDTGRDVGGNVRQKAKEISSLLMDDARLAEERSSRNQMRDRMAGVDNIMAEYQLPRGDRRGSFDRPGYQKPERNDEDSDLKRALDESRRLAEEKSRGGRGDEDDLQKAIRLSEQEARDKERRDRERLERENEDALFGKGGTDSQQSSFNPFPQQSTVNLYQQQQQQVPWQATGATNMTFSNPISGNPVYSQFTGVPNNPYQQQTVANPYQQQSQQYTGMLQQPMVTGMQFQTPQMTGMQYQQAQPTGMQFPASSSMSNIQAGQNNPFGQTNGSNSQQSAFGSSPSMQTSSFGQSLQPQQTGIQASPSPQPSPASTSQVNYPTTNSSKSTPAASRPNDSKFSKLNALLASGGDGIDSFGNTGNLRIPVGTGFANSMQVKYNSDNNGGENARMGESTGDANIGSSSNVPKNFDASLLDSPAQSFGNQSSRNPFGQPTASFSSPTSNQGDNKKSLFEMMQEQKLQQQIPSQPTGMNFQTPQMTGFQQNQMTGFQQQPQMTGFQQSPYNNGQQQQSGPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWY8</accession>
    <name>A0A8H7PWY8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_008561</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18982at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13329">
        <property type="entry name" value="ATG2_CAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1040"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1397"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1571"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1619"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1656"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1989"/>
            <end position="2022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1399"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1674"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2180979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="2133" mass="239904" checksum="7D696AAF23B9D09B" modified="2022-01-19" version="1" fragment="single">KSIGRFLAQELDLENFDVEFINGNIEMRDLDLNLEVLNDLISESPFTITEGYIGGITASVPWSNFWSGDIVLEMRGLRITLKPELNKPKKEKQRMDEEPVLSTSIHLAGDFLKTEVPPDEDEDFRQSIHLSGPDSPPFDSLNQQNVNVEGLQVLTKVIDKMLARIKIKIIDSVLRIHHVSHISLSTDVPNQGGNMFERETHDYYLDIQLPSISYFDETPGLSDRDSNEPTPPDINMQSSSILLPPAINESIKIIVISSPTIWIRSGLERSINSLQRERYPEMESSVAESAILSNQSDTELNDSSMFHSAIGDSQLSGSITPQARPASPDLDIDTIYESLIFSTLDKDNWFRLKFSSGEPADWSTNVQISDMSSMKQVDVIMSSLCIALSPKQMVLVNELLECLSGSADTPNTEMSAEYGTAQNSPQDNDADVLQELLTNKNDGGKLHEDMFNSPAFIPQSPSYMTANNLDFNGGSPSRLENPLGIQQLTLESNRDQWSSSMNFQNPSGHRSGREGGRNLGFSTLQHQKQAIPSIKVKFSMAAADLYLLMDEARPVVPPAFFSMPNPALLGANHIRLSLQQIVLRYKDWSSLSNATPYHEREGRKNITGANLSDESAISRPKTALDVRISHMALQEWLKRPEHEPNLPEFSKYHYEVYTPILQFSELLPKTYRSQDDFPTISLADLSQQEGKREALRLKIELWSSKIDSPGRQDVLVDIKPFQISVDLRILDRMEKVITTFINRPKKEEVTGLTSRNVEGRYPRQTSERDIYADLKQTSEDTKLIKTYNVKLAFIRLLLLTPDMSRATKRFESTMYVRDDYLVVDIIKLSSRHVVDDINENSHSNSKPSLGEDPLEDIDYLNLNRRDGMKIGKSGEKIQLNFECENVNVFLKKARDHEPICWFMVKPGTDTSIATAKAIPKLSTYQISIFTGSSESKSNSNPFIPYDEPMDHDIPYAIFDRLKNDENIHNDEEKIHIPSDEQSESTSRFKKHSWDTSMFAIKCVLPLTRMNLTKESWDIVQTIQNDLLLWQPKLLSSVNNLPQDTDDSSNDVFSSPVAQEESGHDPQRSEFNVASGQYETNVAGSESISPHVAAPEKYSLLAITACLQRAEWMLHHSNEGLDDAANFNTYIAVMDNFQYGSVIKHKGQDENITTLDIDNVSLSEVESEDTSQLKLDRNIPALLKYNAPMVSILTLLKSQPLTNVQEKSSSIVISNLKFNYNSNIDFIDNLIKFQNAPVTMNVVDPPVTYIKVYVTVNDTTVSYAPADNTLQAAIILDDLKIATDVFQNQPRLFINCQLRALDLYMADDRSELNEEDAISHLKGHGVTASRWWRNVGMARCVAMRDFAVSVSLGMREEEQLNLDVALTNHVLGLEFCKDSLPAVLNFIAVVTASTRKAEVPEDDQLDDLDDTGKTEPAADSVQSEPINMLQSLDERAFSLQGEQPEESSRRLSSDMEYVEEYYSSAKANRDDAASNPTNADVEEMHIVPPRKPRRKNAASVSEDIIHVMDDGIRADQLKIEEDHFSKDRPNVTMKPKVDVSKSVKRIRLKDFNVVCKLYDGCDWRHTRRNSNEFSVPQSAPHRPSTSTSVPLSHNASQEGTYASPVQSPVSLYKEDVEPAVDYTRPMHPRTSSDYAGEDFSDTTSQYSRFQYSIKDGKQPSSYHRRITGSPDSHTSKLHARRLKNSRSHSARLEIRLEQINVEFDLLPVTEQLASHLQIHIRDFEIIDHIKTSMYRKFLSYMRTDRHPRERGSNMIRFELTSVRPVPYDLAEEHRLKLRISPMRLYIDQDAILFLINFFSFDPKLLHSSTPVGNQTAARGSQRGPSSNDNDTFFQHVEIYPVLLKVDYRPKHVNYGSLKEGQFAELVNFFHLDAAEMNLSHVKLAGIKGYDRLVQAVMNNWLPHIRDTQLGKVVTGVSSIQSVVNIGSGVADLVLLPIEQYRKDGRIIRGIQKGTQSFARTTTMEAIKIGSRLAAGTQVILEQADEYFSPAATNESFGRSSDDYGSEEEPSQRATELMQGDSDSDSQKVISKFADQPTDVSQGLQHAYQSLSKNIMSAANTVLAVPTEIQASDGPHGTAKAVIRAVPIAVIRPLIGFSEAFANVLVGIRNTIDPDQKAQSVEVCHKSNFHMVSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PY74</accession>
    <name>A0A8H7PY74_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PY74"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2182447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="67" mass="7423" checksum="9EFB29998856B508" modified="2022-01-19" version="1">MTFLEIYGLFTASLQSILQVMIIVLIGWVLARDGLITEMAGSSKHEFFHAVPVIHENGSGYHSKDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYE9</accession>
    <name>A0A8H7PYE9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYE9"/>
    <dbReference type="OrthoDB" id="2341448at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2182411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="214" mass="23742" checksum="B3F8B07E1DCCD77C" modified="2022-01-19" version="1">MSTINPRVVLFSVVITKLIFDRIYRLASVINPAAGESGAPILDILEYGHPASSDEIYRIIGFYGPKGREAYLQLAMYDTGFVLMRLLPLCVFAQWSLGRYPRVANALIYFHVVAAAWDVIENIILFIVLKAFPGRYDGLASLLCTWISVKWFFLYATGASVAGGLLVGLYHSFHSLLADSVLMEKDRTNPKPQSASNSKQNASKSTAKRSKKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYR7</accession>
    <name>A0A8H7PYR7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_007117</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mitochondrial transcription factor that confers selective promoter recognition on the core subunit of the yeast mitochondrial RNA polymerase. Interacts with DNA in a non-specific manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYR7"/>
    <dbReference type="OrthoDB" id="16079at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034246">
        <property type="term" value="F:mitochondrial transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006391">
        <property type="term" value="P:transcription initiation at mitochondrial promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="entry name" value="Ribosomal RNA adenine dimethylase-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF17">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 7 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2182190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="357" mass="39923" checksum="CDE90A086E5CC8B7" modified="2022-01-19" version="1">MSLPRVTPNIPQLKQWPRLFKSTLTSKSAIRLNLINSHTADRAMAELKLNSPEKMTAVELYPGKNACTKLMLSHSSIIDPFCLPTKIVLTGIGVWSSALLNGGIKKVIGLEPNAKFLPFMKELSNQTSGAIESVNLDGYDWSTYMQLKEDSMLGSKARADWSKVHPELLFTGTIPKSSKGEQLLAQLFGCIINKMALHSLGRIQMAMWIPTSIYTKIAAPPGDPARCKLSIVREACTDISVVTAPEPDNFYPVNDYQLLNIIPLAESRIHTDWDVFEYVLRHIFVTKRQKLSKAIKTLGPGAEILTPRLSFDPNTLVGELSVEQIDEVARKFDEWPLRPKVLFEDASVFDDRLKTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZD2</accession>
    <name>A0A8H7PZD2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_006241</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZD2"/>
    <dbReference type="OrthoDB" id="1053771at2759"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03312">
        <property type="entry name" value="CIMS_N_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000002">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003556">
        <property type="entry name" value="PRK05222.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE N-terminal" evidence="15">
        <location>
            <begin position="4"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="14">
        <location>
            <begin position="441"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="709"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="446"/>
            <end position="448"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="446"/>
            <end position="448"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="530"/>
            <end position="531"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="576"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="656"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="658"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="680"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="741"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2183237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="771" mass="86919" checksum="896BDDEA22270CAA" modified="2022-01-19" version="1">MVSATNLGFPYVGAKRELKKVVESFWSGKASEADLVSGAGKLQELHWKVQQEQGIEQIPSGDFTLYDRVLDTACNFGVIPQRYQHIQNPLEQYFAMGRGLQKAATETSEKVDVPAMEMKKWFDTNYHFIVPEFEPTQKFELKAPRVLEQFKHAKSLGIKTRPVVLGPVSFLHLGKPAKGADAFNTLELLPKVLPLYTELFKQLAAAGAEWIQVDEPILILDLDSEVKLAFEKAYKTLKGASQAKTLLTTYFGRLDNNIYVVKDNVDGIHLDLARNPEQLEAVLPILNDKQVLSLGLVDGRNIWKDDLNKSLDLAEKAVKALGSERVFVAPSCSLAHSPYSTAFEKKIKSENPELFSWLSYSVEKCAEVSTIAKALNGGRASVQAELDANAADLESRRTSKQTTNPEVRERVAQVPAKDYKRASPFPHRRDAQVKKLNLPLFPTTTIGSFPQTKDIRVARQKHNKGEISDAEYDQFIKEEMKRVVEFQEKVGLDVFVHGEPERNDMVEHFGHLLHGYGFTENGWVVSYGSRCVKPPVIYGDVSRRCPMTIDEIVYAQSLTKKPMKGMLTGPVTMMKWSFIRNDIPAKDLCTQIALALRDEVVDLETAGIPCIQVDEPAIREGLPLRRQDWDAYLEWSVGAFRLSTSGVRDDTQIHTHMCYSDFNDIFDAIQALDADVITIENSKSDEKLLKIFERKQYTNEIGPGLYDIHSPRVPSVEEMKTRFGDMLKYLPKHLLWANPDCGLKSRGWPEVEAALINMVEVAKHFRDQESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0P6</accession>
    <name>A0A8H7Q0P6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Histone-lysine N-methyltransferase, H3 lysine-79 specific</fullName>
            <ecNumber evidence="2 11">2.1.1.360</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Histone H3-K79 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_006664</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60328"/>
            <dbReference type="Rhea" id="RHEA-COMP:15549"/>
            <dbReference type="Rhea" id="RHEA-COMP:15552"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.360"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.360" evidence="2 11"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0P6"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140956">
        <property type="term" value="F:histone H3K79 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000033">
        <property type="entry name" value="Histone-lysine N-methyltransferase, H3 lysine-79 specific"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030445">
        <property type="entry name" value="H3-K79_meTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451">
        <property type="entry name" value="HISTONE H3 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451:SF0">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51569">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOT1" evidence="13">
        <location>
            <begin position="225"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU271113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2183656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="547" mass="61234" checksum="D44E0A964E6F4B5A" modified="2022-01-19" version="1">MEVSSDEETWGSLRFDSAPKKQIPEKRPNESVLKSTKKPNIKTTAEPSHLLGSEGSTKSNTTELDNAGQKFTITTKPERAEKVNGNHSAEADKSIASTLPSNGVQGLTSRIKTNLEPTSSSSTPVASPKSVKVKEIKHSEKMVQASINRYKPCKFNNVALRPKQSGTISSLQVSIPDFSFTSGNDDSDSSREHSSAKESLRVELEYPKPGVAERFLLLKPVLVNPKTKVPDSDQEDKDEYNPITDLLRTANAIYDYFLTPDLQKLLGDDTEGTMRNLMKHRNRRNGAGFIQAVNEFNAVMRQAKAENKLTGKRVRPTYELVCHILYQVYSRTVAPHAEALNNYQAFSNHVYGEINSILIKEFIERTNITSKSVFIDMGCGIGNVVLQVAAQTACEAHGIEIMETPCKLAKLQLKEYATRMRAWQLPSGNIRIRLGDFLESVEIHDALKRADVILVNNYAFDSSQNQALCQLFLDLKEGTQIISLKSFVPVGHKLNERTAHAPESILRVKKYPYYTEAVSWTHNGGAYYISTVDRRPVQRFYQRMMGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q198</accession>
    <name>A0A8H7Q198_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bacterial low temperature requirement A protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42101">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42101:SF1">
        <property type="entry name" value="LOW TEMPERATURE REQUIREMENT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="484"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="512"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="681"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="735"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1006"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1068"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1100"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1127"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1179"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1224"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1260"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1268"/>
            <end position="1281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2183214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1443" mass="160787" checksum="11E281EA15EEEDB1" modified="2022-01-19" version="1">MSQRRGGSQNRHNLRHHAGNTEHGAGDNQQNNYSGEERGMLHDTSSGLNMSPDISNLSNPSDVPVQYDIFGKPVIPHGNETFGDIMLHPTKQLAMHKKRVEKFKHDHDLVPEAAPEARMASLVHVRTRSVIHFKNLIGDQTIKMTDELCKDISTELSLSLEEQSEMRKIKNTDGLAKVLRKFGRDFSIKVHNSEDIHPEKKHSPAQSPELNEKAEQGHHYPLEQPATATATATTDQEKLDANNTLAPTLSHLSSHSDVAAGRTSTDSEKAHLAEGSAIIHLNSNVYLEVKKIFPEEEEEKFEELMPKRRAFFNIPDPDLSDEIGEESSASWLELFGDVFYVGWLTTFTHHNHITDGSTLANYVGWFVVMWWSWCSSALYSSRYDTGDVVHHIYKLIELCALVGMAGASNTYASEDHLGFVLGYIVSKAVLLIEYSVVFTVALITGSHGKLPLACYVFVNLLSIILWGASLAFGSDAQRASRFSLWYISIVIELLVNIALKKNKQVSVAGSHLAERFGLFTLIILGENMMGFITLVSEGASEDIKLICANMMGVIIIFGFFFMCFDDFSAQVLLEVNVSQLWLYLHFPLHLCQVALGIALQDVIQIYGQHWDYVAMGCPSASSETSELPATNTAETSHIVQNVSGRALSLFQSLQYSATPAEGTSITEGSGSEAEGCLNVDFVFKTFLVAAGLVLMLNAFIKFINTPVNSRWSKYICASRAINAIIFFGLTQVVHQINSIGLLGLLTGCLILQFRSKSVRRGPTVRGRRPTIGRAGRRKQSLASDEEILTRSDSDTATEEVELHRVNVPPTYIHGNETFGDVIVHPVQQFEAHKQRKAQFEEQRRSWQLEHGPEKDDTKNLRAEQSFAIEYETATEFGRKLKLTQKEKIMFNGVHDTESLTHFLHQTNRDYAIKVHHGHGESHHAHHHHQTLDLSSNIYVEFKPKLQEVVHEDSSASTRRPFFMFPEADLSADIGEEKAASWLELFYDLFYIASLSEFTHTHVIKDWASLGVYASWFVIMWWAWTASSLYTSRFDTDDVMHHIYKLIEMCAVIGMAGTSDHFLNSSGFVYGYITLKAILAIEYAIVFSVALMSNSKSRIPLLCYVVANLISIILWGISLLFLDSDTHFAFWYIGLFVELLVNLVVRDNKRLSWAASHLAERFGLLTLIVLGENLMGFVKLVAEAGTTIHVVIPNFMAVVIIFGFFFNYFEDFSKEVMLHNRYHQLWVYLHFPLHLCQVAFGIAMINMLRIYRLQYEKSHAETQPAGEPSTSSEASGVAASEAPTASGSVAEPTDGSSTNVAKRDIDDIYHHAAYELAARAIEDTSGDSIYYDPISLSEISSPSQTPIPTMTSSILATVAAVSTSVAFSTLTAIQQKVEAGTNSPTEAAGGESEADLTPDEQTFVYKTFLITGGLILIINSLIKLLNTKIHGNYSAFHINDSTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q208</accession>
    <name>A0A8H7Q208_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Lysophospholipase NTE1</fullName>
            <ecNumber evidence="3 16">3.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Intracellular phospholipase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">INT43_000381</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the NTE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="3 16"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q208"/>
    <dbReference type="OrthoDB" id="421051at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046470">
        <property type="term" value="P:phosphatidylcholine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000062">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000007">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001423">
        <property type="entry name" value="LysoPLipase_patatin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056556">
        <property type="entry name" value="NTE1_P-loop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF29">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE SWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24179">
        <property type="entry name" value="NTE_Ploop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01237">
        <property type="entry name" value="UPF0028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 15 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 16" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11 15 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="18">
        <location>
            <begin position="550"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="19">
        <location>
            <begin position="956"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="188"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="378"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1236"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="15">
        <location>
            <begin position="960"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="15">
        <location>
            <begin position="987"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="15">
        <location>
            <begin position="1107"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1236"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="15">
        <location>
            <position position="989"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="1107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG2184472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1259" mass="138788" checksum="08FD205E66ABD384" modified="2022-01-19" version="1" fragment="single">KSPPLIYKHLQQDDLSDLEEDGNIRVNSTNNSSDKPFSNMHKRPSLMKRNTSFKQQRSVHPGIIARATVDTTLAVIPAEAFHKLTQKFPKAAAHIVQVILTRFQRVTFLTGHKYLGLTKELLRAERLANESASLKRLPEEFFIPGGLDRLRRKFIADEKSFTIAGSESDEASKNEATNRPSIIQAMNISEHPSPSPSLESTNSNITGGRKSSGREKLRRGSVHRSNSDYSLEDDRHLRASVMACISQSLGLRSFAGAEDLTPPNLGMNRSPPSSHLDVSKARYFPMDLFSHTGVIDDSGSPSIGPISMASDDIEVMSNASSVSNNDHSFDAKFSSTVNANDIQILYYPKDAVLVKEGEHNRGLFFVIDGLLEVSMTPVDGEDEPQVAPRRPTNTNSSRGSRRRRSNQMKFPLASNNSYVDDPFATPAPDTSEIYNEKKKSAEPNEAQQRRTVMSDAPAGRSYDDKDGDSKRKRTRKSLFTIKAGSMAGYLAAMSGYPSFVEIRAATDTFVGYVTKQTLERIVDRNPIVMLTLAKRLISILSPLILHIDFALEWVQVPASQIIYRQGEPSNSIYIVLNGRLRTISERKEGGIDILGEFGHGDSVGELEVLTGTSTPSTLHAIRDSELARMPKTLFNALAVRHPEITLQISRLIALRSRQLVIKSQSPQGAIVPTFNLSSKDISPVASIQSTFTNNKFPELFGRNNVNLKTVGIIPVSSSVPVTAFAENLRSALVNSVGAETVLLNSATIMSVMGKHAFSRMGKLKLMSWLADQEEKARMVLYLADGGVTSQWTRTCIRQADCILLVGLGDGDPAVGEYERFLINMKTTARKELVLLHGEKYCASGTTQEWLKNRLWVQAHHHIFMPMRQHLGLSNHQGPGPAWLRNHGRKMTAGSINMLNNVKGQIEKYYGAVRVPTFGRLLVLKKDGGGPVSGVSSGTRNDFSRLARRLCGKSVALVLGGGGARGISHMGVIQAIEEAGIPIDIIGGTSIGAFVGGLYAMNADLVSTMARAKMFSGRVASVWRQLMDVTYPVTAWTTGHEFNRAIWKCFGDSQIEDFWLPYFTVTTNITYSRMEVHTAGYAWRYVRASMSLSGYMPPICDNGNMLVDGGYMDNLPVTVAKSMGADIIIAVDVASEDDTSPVMYGDSLSGWWALLQGWNPFRTYKIPSIADIQSRLAYVSSVAKLEEAKLTDGTLYIKLPVQKFGTLEFGKFHDIFSIGYDAGKELTNNWRKFATGRLEHTDKHQKGTEVKGNASRRNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2A3</accession>
    <name>A0A8H7Q2A3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2A3"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000052">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1020:FF:000002">
        <property type="entry name" value="Trehalose-6-phosphate synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011071">
        <property type="entry name" value="PRK14501.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF123">
        <property type="entry name" value="TREHALOSE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2183739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="831" mass="92878" checksum="2F500124584CBDD2" modified="2022-01-19" version="1">MPHIPTTPGIDTEAIKSFLPFAGEDKPAFHGKVINVTHHIQYSCIKKSEANQETSVLDKIRSIVPGTGTQSTKLAADDAPISRLNKRRQTQITIGESPEWRLTQRGGHSAMYSGLDALKKSWDTVYIGSPGPLENEDGDVIPTEDLQDSDKEDIKKLLKDAGDIIPIFLGTDVSAGHYEGYCKKVLWPLFHYVTWAEVTNGSAENKYWKDYVQVNAAFTDAIISVYKPGDIVWIHDYHLLLVPEMLRTKLPQAASGLFIHAPFPSSEIFRCLPRRDEILRGMLGASLVGFQTYSYSRHFISCCTRVLGYESTPSGVDAQGQLVSVGTFPIGVDTEKIEQYRKDPGVAPKIAAIREMYGDKKIIVGRDKLDPVKGVIQKLNAFEKFLTDYPDWRDKVVLIQVTSPGVTESRKLETKVSEMVSQINGKFGSLEFTPVHHFHQHIDRDEYYALLTVADVGLITSIRDGMNTTSMEYIICQQENHGPLILSEFTGTAGSLSAAKMVNPWDYAEVAAAINSSLLMSEEKKAARQTKLYKHVVGHTSKYWANSLVLELIATSEKPDQSNITDVLDIERLKTKYASAKSRVMFFDYDGTLTPIRTQPNAAVPSKEMIEYLTALCADPKNVVWVVSGRDQAALDEWLGGIPNLGLSAEHGCFMKAPETNKWINLTEEIDMSWKNDVIEIFTYYTERTQGSFIEHKRCALTWHYRMADPEYGTFQAKECQNHLENAVVSKLPVEILVGKKNLEVRPTSVNKGEIVKRLLAQHLDADFVFCAGDDKTDEDMFRALRKCDSVQEENVFAVTVGPSDKKTLANYHVDASEDVINVIGIMAQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q355</accession>
    <name>A0A8H7Q355_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q355"/>
    <dbReference type="OrthoDB" id="2454457at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034819970" evidence="1">
        <location>
            <begin position="19"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2185087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="108" mass="11754" checksum="03B8E92B1A8490D9" modified="2022-01-19" version="1">MIGYKTPLILMAIAYVSAVPLTVESHGQLERRQDGQPSLHLPDITKIITLCPLQCSPIQKLAQCVPECLNLLNLDRCVLCTGGTFNEVVNCVECVALNVLPTFGTETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3P0</accession>
    <name>A0A8H7Q3P0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_000636</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3P0"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="216"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2184723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="30600" checksum="DE79E8C2C949F438" modified="2022-01-19" version="1" fragment="single">LNIANPATGCQKLLEVTDERRLSAFMDKRMSTVVSGDGLGDEFKGYEFRISGGNDKQGFPMKQGVLTPNRVKLLLSSGHSCYRPRRDGERKRKSVRGCITSPDLSVLSLVIVKQGAHDIPGLTDSSIPNRLGPKRANHIRKFWNLDKEDDVRKYVIRRTVHPRNPDKKPYTKAPKIQRLITPRRLQRKRRLKAIKRRRAEVSKEEAAEYKKLLATRLKEAKQKHREDVKRRHSSSSSAATSKPKGPSEISVDEMLENPGKVNQKLHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q427</accession>
    <name>A0A8H7Q427_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">enoyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_000846</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.104"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q427"/>
    <dbReference type="OrthoDB" id="7482721at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000112">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="41"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2184933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="388" mass="42768" checksum="7ADDDD5EF473BDC3" modified="2022-01-19" version="1">MLSTRSINLVTRPLSAVNAIRLSSSSSKIQASAMVYSNYGKPSEVLSIHKHYLPELKPEDVHIRFLAAPINPADCNQVEGAYPIKPPFTNALGSHDPVAVGGNEGVAEIIAAGEQVKGFKVGDKVIMANAGKGTWRTHAALPATDVQLLPGFNQDVSLVHAATLTVNPSTAYRMLKDFTLLQQGDFIIQNGANSAVGQSVIQLANAWGLKTINVVRDRPNLDELRQYLTSLGATHIITEEELSKRETRSKLKEWLNGRKLRLALNCVGGKNATELGRYLDHEGKHVTYGAMAKQPMQVPAAPLIFKNISFHGFWVSRWTDTHSAQERESMLADLIDLIKQKKLKEPIWEKVSWKVNAPEEETLKTFREAVDKGITGYGKGKQILVFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q435</accession>
    <name>A0A8H7Q435_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q435"/>
    <dbReference type="OrthoDB" id="2402731at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="238" mass="26732" checksum="42DEFA633F62FC42" modified="2022-01-19" version="1">MSNSNTNSNHFTNSQQSPKHSPMERVIPRPQPLHNPSLSRHHRAIDRPSMSLGNDQAFIEFSRCLYQAKTIVKELQAFSASVSPSLRMSMLRQNNLTDGQDNQKETAEQFLNSIRHYLETTFEKFARLCKVLMFVLSKMEASGNVRIERITSFRRDVTEAWRVANDIKDRLNALIAQESMFLNYGDTATPASMASAAYNGPRSAPSPCESQNTDKMPAYSQASPSIASSPASSPYNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q475</accession>
    <name>A0A8H7Q475_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_002632</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q475"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="53"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="545"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="570"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2186194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="614" mass="66155" checksum="24BDD71A171E910A" modified="2022-01-19" version="1">MSRPNSVHNNHSEPTLSEPTLTDPPEQQAPVMPQNPTALSEEDRPKGVKLALIFLGLFFSILLAALDQTIVTTALPKIASEFNALNQISWVGTSYMLTSTAFQPIYGKLADIFGRKHILMLADIIFLIGSILSGAAQNMIMLIICRAIQGIGGGGIIAMVMIVIGDIVSLRERGKYQGVIGGCWGIASVIGPLIGGGFTDHASWRWCFYINLPIGGIALAVIFFFLQLPSPKSSILEKLKRVDFIGTALIVCAVVALLLPTEWGGITYAWNSGIVIGLYCAGGVLTILFLALEKWFATNPVIPLRLFSMRSPVCIFLSSFFFGMAFFTGIYYLPLYFQAVRGDSATAAGLELLPYMLGVVFCNILVGLIISKTGAYRIWLWSGTAILTVGSGLITLLDMNSNRGEQIGYLLVAGVGFGCCMQTMIVAAQASVTYKDMAVTTAFVNFSRTLGGVFGLAVAGTLFNNKLIAGLATLNLSPEVSQQAANNVQFVNSLPSSERTIIVQQYVTALRLCFTIMIPFGGLAFLSVLGVQHFALRKSLGDAKTPASKDVTAEKGSTQDSKEGMVNTQDSKERKEDTQELKEGKEITQEIENGQEKDLEKGQFVHGTNSASEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4C1</accession>
    <name>A0A8H7Q4C1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_000350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4C1"/>
    <dbReference type="OrthoDB" id="2340041at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2184441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="76" mass="8729" checksum="5114D8C4D320C461" modified="2022-01-19" version="1">MGIQYKDTTQSHLELNQDSLENAKREYTRQMRLWTAKQIKSSRVDKAPEEMLRSRFSDLGVSSPKRVPSNCAINAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4Y9</accession>
    <name>A0A8H7Q4Y9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4Y9"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03114">
        <property type="entry name" value="MMAA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006958">
        <property type="entry name" value="PRK09435.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23408:SF3">
        <property type="entry name" value="METHYLMALONIC ACIDURIA TYPE A PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23408">
        <property type="entry name" value="METHYLMALONYL-COA MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03308">
        <property type="entry name" value="MeaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2185973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="404" mass="44099" checksum="D379A1B7E7AAA45A" modified="2022-01-19" version="1">MLSRNLPTVSPCPSRAEVLAFSLYMLSRRLWLSNPTAKVRPLFRPPLYRTTALVTLRCTYGTATSSKSAQLAEQLEQGSRYALAKSITLVESSRSDHRALAQELLSTVLKRQKESKDAKPTFRIGLSGSPGVGKSTFIEAFGMYLLEQGHKVAVLAVDPSSSRTGGSILGDKTRMTELSRADDAYVRPSPSRGTLGGVSDVARNTNEAIILCEAAGYDVTLVETVGVGQSETMVAEMVDMFVLLVGPGGGDELQGLKKGIVELSDMVIVNKADGKLEDAARSAAMDYTSAIKFLQSPSPLWKAKVVRVSSRNNIGIDKSWEIMKSYFDTMTAAHKLAEKRGAQRKVWMWRQITSELVDRLNGDENVKKHVAKLESQVFDGKMTSGQAADSVVDVFLNKVKENKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q542</accession>
    <name>A0A8H7Q542_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_002145</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q542"/>
    <dbReference type="OrthoDB" id="1294322at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2185710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="277" mass="31967" checksum="5832CDD797936686" modified="2022-01-19" version="1" fragment="single">QLQPCAVCTEDYVAQEEALKLPCSHIFHQDCIVPWLRMNQTCPVCRFSVESRPSSSNSGPINPISRANSSLMSIIPDGIQRLFEVGFTGHPLKLPLHLHIQMASRLNEYQVVGRKLPSEQEPVPKLFRMRLFAPNDVNAKSRFWYFLKKLRKVKKAAGEIVSVNQIHEKRPEQIKNYGIWLRYDSRSGTHNMYKEYREMSRCAAVVACYQDMAARHRARFASVQIIRVAEISNADVRRPYIKQLLTPKLAFPLPHRVIRSQKGNRALFSAKRPSTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5I3</accession>
    <name>A0A8H7Q5I3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Cytochrome c oxidase subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Cytochrome c oxidase polypeptide VIIA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_002373</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the fungal cytochrome c oxidase subunit 7a family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5I3"/>
    <dbReference type="OrthoDB" id="2317211at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22888">
        <property type="entry name" value="CcO_VIIa_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014368">
        <property type="entry name" value="Cyt_c_oxidase_su7a_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000283">
        <property type="entry name" value="COX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2185935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="56" mass="6312" checksum="D9365DF037926119" modified="2022-01-19" version="1">MPIAPIAGKLRKRLILDISVSLGLGLTGGYAWWNLYHIPSVQRRDAFYAKLEANKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q604</accession>
    <name>A0A8H7Q604_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_002628</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q604"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="36"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2186190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="186" mass="20563" checksum="E20730A07D38D23A" modified="2022-01-19" version="1">MSLNRVFPEILRDASRAFALLEEPMFNVARRNAFPSLSSMMRYPATDIRETKDAYVLEAELPGIRKEDVDIEFQDNTLVLRGKLERTTQHGEPPQAAPATPAESETTQAVESASSGDTSVVQKDAQTSKDLTPHWWSNERITGSFSRSFTFPGSVQTDAIKAAYKDGVLSITVPKAQKASSRINID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q646</accession>
    <name>A0A8H7Q646_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q646"/>
    <dbReference type="OrthoDB" id="2288617at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2186250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="245" mass="27472" checksum="9739A1F3716DDA4B" modified="2022-01-19" version="1">MSLDVLSTGSDFLFPSASPVPKLVADPTPAQNSIDWASEEYFSTVLDKILKPENVRTMNNYTEKPHLAAQKKEASCWHDPFLLVLDQPRMNVDIRAALKGALSAIDNEMQDNAKSKADVDSQWKKEATETLEEVQIAAPTQAIFYDELLPSPCYSTISDNYALDSAFVFSPMASVIEESMMFPHPHPTTQTSTTQEVSEATNTNKQNKTKSKFANMFKKVKLSVSKPFTKTESINPFKRLLGRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6V2</accession>
    <name>A0A8H7Q6V2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_002843</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6V2"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF236">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="108"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2186405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="213" mass="23915" checksum="97381B74EF3DC5D9" modified="2022-01-19" version="1">MKQIKSKWPKLFPKSDLQVNELLQGQIYTIPDFFTVKECDNLIAHIEANIPLQKTSGIPKKGEALRSNDRVSVSDPAFADLLWCLGINTVSTSTQAIYKAALPDVPVGLNSNIRIYRYLPGQRFECHYDDTVRDERTNCWTEWTLLIYLTGEDEVSGGETVFYKTEKKKSSVVVAPSKGTALLHRHGASCLLHEGKEVTKGVKYVLRSDVVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U6L2</accession>
    <name>A0A8H7U6L2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000023">
        <property type="protein sequence ID" value="KAG2171261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U6L2"/>
    <dbReference type="OrthoDB" id="2429052at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2171261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="123" mass="13978" checksum="6FAA515129BC89DE" modified="2022-01-19" version="1">MLSLACTSYFTIPSRWEKRNRDNAFTAYENIALRVTEEMGQPNIACADIHDSVNEETLEYLRGLKILVFASVAEDGNISYYLQVLLDVSNPETSRVAKRLKTKSLDVNMAKLRDCTGRFLPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U6X4</accession>
    <name>A0A8H7U6X4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL11m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_004838</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U6X4"/>
    <dbReference type="OrthoDB" id="1091498at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000006">
        <property type="entry name" value="50S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000003">
        <property type="entry name" value="Mitochondrial ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_uL11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="10">
        <location>
            <begin position="44"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="9">
        <location>
            <begin position="107"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2172296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="179" mass="19232" checksum="E6C38B33AC7EBA44" modified="2022-01-19" version="1">MNRIKCSRDLQSHPFQATSKKFGLQVIASTVEMSKKPAAAEQFVRLLVAAGKASPSPPVGPALGARGVKSMDFCKQFNDKTKNIVAETPIPTVITIKPDRTFTFITKSPPTPFLLKRAAGIEKGASNPGTEIIGKVSLKHVYEIAKIKQQDSNLKHLSLQSICGSIIGVAKSIGIQVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U880</accession>
    <name>A0A8H7U880_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_008348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U880"/>
    <dbReference type="OrthoDB" id="2354979at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2171622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="31595" checksum="F90F98ED7E9E5DD9" modified="2022-01-19" version="1">MAPPRIFLRYTEVVVCDVLAVLVRYQPQYGFNLTPVQLMISQYGQTKASSPFVRKGCQTACVRSAHIGKTKRHAGLSLFSPLAFPPNTMIAHLPLHEKRKILVYLGAHDESLFKWTCENVLRPGKDHVVLLACVPRSARRRSSTSSTGSFDGVRRRMSLPMVAPVSTNHSSTNSNMSTLPESVVWEDVDEARDALERYSRTLLEDNITNEEHVVPGDPRDLLPRFARDHGGMNIVVIAGEPSKKLSLGSTTLGERVAKEVGSQCTIVTVRNPQQLDIGIPAVVAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8C4</accession>
    <name>A0A8H7U8C4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit tim23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_008182</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8C4"/>
    <dbReference type="OrthoDB" id="159299at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2171802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="22595" checksum="0950E9EF55044703" modified="2022-01-19" version="1">MSWFGGSSSSNNASNSTENLDDAYSTGGALDTGMSSYESIDNSYEKVPDFMSAAAVNATRLHPMATQGGIDFLQLEDSVGGSGGAAAGGAALTPSRSWSDDLCYGTGTTYLAGLTLGGAVGLAEGVKKGTGSPNMKIRLNTTLNSITRRGPGLGNSVGVIAMIYNGTNSMIGGIRGQHDIFNSVAAGGIAGALFKSTAGVKPMGMAAGACAAVAGVWSLGKDYILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8U4</accession>
    <name>A0A8H7U8U4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_005200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8U4"/>
    <dbReference type="OrthoDB" id="206335at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000031">
        <property type="entry name" value="RNA exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="7">
        <location>
            <begin position="271"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2173780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="638" mass="71928" checksum="2042CC968D7E029F" modified="2022-01-19" version="1">MTCTLGTSNLFAYSEQKPSDKTFHDSSIVNTPDAYYTRIFEPDQSEAQVNRKTQPHKRRRNRKKDKLVLAYGSILISVNKLNQPVTFNSNGFKERLAIKDLRQFLLSCLADGVKPSWIHLKSGHQIRKFVVVHVLGFDSSCFDLPYDSNDFIKIDDMIKPCSFIDYMPFATELFGEVIALKSTKELNVVDEFCQCPLSNAERQRRATARRAKTKSAMQFTLEDCTLTLDEMLEAGYPIHSKLLGHSNLPTSWVQTSQRQPRIGDLTAEGENVIAIDCEMCLTGRGLELARVSLIDYASNVILDEMVQPSHPVVDYMTQYSGIRQANLEGVTTTLSDIQNRLLDIIDEDTILIGHSLQCDLNTLKLAHPRVIDTSRLYHHRNGPPPLRPSLKHLAARYLDRNIQSYGSTIQSGAELGHDPREDALASLDLVKLKLSRGPEFGLYISNAESIFSRLERRRPPRYGAILSSNLSSRPSIYTQQAQLLRQCGDDEQLFNHLLNEVGSYDFIWASFENITPSKQDIPPYINHSESPPKSGHQYTLSSSKHHGLATLDQRLQVLYNYLPTGTVLVVVGTADAKEQHRQVISNSICSNATCLTNTYYLFTLKNNSTPPLTPTSDSPEVDLKQPFKRTNVCLMKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9H3</accession>
    <name>A0A8H7U9H3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9H3"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2173362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="107" mass="12205" checksum="EB001CA319707A45" modified="2022-01-19" version="1">MFDGKEQELSHNCPAATTIQQPWQSCKMNIMATKKRHGYTQTEGLGQRQDFSRQVQQQLTKRQCYSQVRCATTKNPSWHAENVKKATRSIISTKLLVLKPSASNLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAC1</accession>
    <name>A0A8H7UAC1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAC1"/>
    <dbReference type="OrthoDB" id="3339358at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2174232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="703" mass="79544" checksum="A0972B81B115C314" modified="2022-01-19" version="1">MLTYKSLLRMFGSLQLVQEVSSTNGRQSNGPSPTVDDKEKITVDNIDASNSMANRDFPYIHTSIHSQPSLIDNSSHPGQGTESHSATATFRSTVSRKPYLESPTTQSSLARVSSFPLFPQRSMSYSKLYANMEFNGADIQRPGSHLSSSRRYSKSVDQTELEDNLAIPELKQKSHKLLCLWPLPIITRYTITISAVISALNAIGLLHTSCSAPIYVLYRYEIWNMMISPFLFEFNMPTMLFHAWNMLLLGLFEESLTHVLGGTRAFVNVLLASAPLIFTIRNVFGYVFSKSTGFALPILFFNDALHECSSGFLPFLFSLLVVQSLSINDKYILLYGSDDTNNKYTVRKVSLQLAMCLMNFAAKNVFWWSFSGLISGIFVALIAHYVTNKANNIPSIRLNYDGQTRRHSSAFDKRLPTWRLLLDTLLRGLAVMVLTFLTLLLCNLYYKRPDYVSTAAFGSISDKPQLLTFVTMSAPRRGNPDYLSQTLQSYLNNWPSTPNEDSVYSRIKMLVYTNFAQHSQFELTRQHFSQDQRGQQYIQWVQGNGTDLNQRLHVSRALELATSNDDSAYIALTEDDFPICGRKEWKELMTVIYKANRHYPNHCGVFVGTGGSGLIMKPNIAKKASKLLLQYQDLPPDIILQKCLLGELEECQECSNNLISSKRLLMHHIGYNASTSHERSYNKNEFQCGWRHPFNGNPSVTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAZ4</accession>
    <name>A0A8H7UAZ4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GBD/FH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_001743</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAZ4"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="4">
        <location>
            <begin position="27"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="671"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="718"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="471"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="676"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="718"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2178896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="748" mass="83946" checksum="87D642D712BD6DCC" modified="2022-01-19" version="1" fragment="single">PTTQADSSSWRSSYSSNTYSNPSSADSELTSEREVDVMFEKMLTRRGIHDPSTRATMTAFSIDKKRLMLSQDVHAASSPAPTPVTAPNSLQPSKRSRSIPTDLKEVDRGSPDYYILKFKEPDMKNVNPRLIAHLAVSLRTMPLSWVRQFIDSRGLQAMTDALGIINRKAHKTDAELQMETEILKCFKSLLNNRWGARDVITNPQCIFNAIFSIVSSSMVTRKLVCEVMAFLCYCEVPTGQDLVLRAMDQVREARKEMGRFDAWLNIWEATLDGRGRLGSMVGASGEFKKNGIQSAPDGQLSDYALSNMMLVNAIIQVVDDLELRIHVRNQLNVCGLQRIIEKIKTFSNDHIHRHIQGYKSLAESDTDDMMEIYNDQVLNDLTDPRDVFECILASVEGTRGYEFFLSALQHLLFVKDEGEVRTRYYQVLDSFVSQIVLDNKGLSEDFTSSYGMSVRYLIDKFAEQDQLSTALEEVRETRQLYEQTLEAKNALERDINERGDGMVSKLKEKAASLEDLLRISRHTIATLQDKLQDLQRSYEQNLAAMEQKLKDVANAKMSTDFLVDIVNQSDACTAEKKETLLRAYERIEAQERLEGVSKRTKNSILTPLPLNIPDDAPLATGLSASFKAELAQQFGSSNRLSGFIVPGTAPKLRASRRAPIMFDKLDAIKEAESRRSSNGSTKRISTGESSTDDDYEEISSGLAAALKARMLKLSAKYAERGADSDASDRFSMEEQPVEDNSIHVETSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UB38</accession>
    <name>A0A8H7UB38_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UB38"/>
    <dbReference type="OrthoDB" id="5366606at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034188046" evidence="1">
        <location>
            <begin position="21"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="167" mass="18426" checksum="7321FCEF84542D57" modified="2022-01-19" version="1">MYKTTLVILFCLFFIHNTFAAMSFKVFLREGIVGGFAGPTIKQVVEINGDSNGAVVAHSTLKPGSKFDYNQASGDVSPQEIHTLMSDLHSQLSQLPLEKPMGSDDIYGRDISLGFFTDDFQWQNGGPEGCNRSPSETKATDQQKAVFNELVERVLSLGQKFAIKKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBA6</accession>
    <name>A0A8H7UBA6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">INT43_002091</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14"/>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBA6"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF5">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="18">
        <location>
            <begin position="57"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="19">
        <location>
            <begin position="391"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG2179241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="585" mass="62015" checksum="088F8E92E7F34BF0" modified="2022-01-19" version="1">MAEQGQVHIHKINPRDKDIKANGPINKYSRTITQTPTAGAAQAQLYATGLTDSDFAKAQVGITSFGYDGNPCNMHINDLAAKVKEGVNKAGLVGYQFNTIGVSDAIPMGSAGMSFSLPSRDIIADSIETVMSALWYDANISIPGCDKNMPGCLMAMGRLNRPSIVIYGGTMKKGKGTLGSCAGREIDIGNALECNGELISGKINEEERRDIIRNACPGAGACGGMFTANTMSSAIEALGMSLPYSSSIPAVDPLKVQECLKVGVAIRTLLERDIKPSDIMTRKAFENALTIIMVLGGSTNAVLHMLAVAKSVDVPLTIDDFQTIADKTPFLANLRPSGKYVMEDLHAVGGIPAVLKYLLQEGMLHGDCMTVTGKTMAENLAEVPDLTEGQDIIRPLSNPIKATGHLTILKGNLAPEGAVAKITGKEGLSFKGRARVFDDEDKIFEALEQGTVQKGDVVVVRYKGPKGGPGMPEMLKPTAAIMGAGLGKDVALITDGRFSGASHGFIIGHICPEAQVGGPIALLKDGDQITIDANTRELTVNIPDQELEARRQQWTAPPLKYTKGILARYSMTVKSASEGAVTDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBB3</accession>
    <name>A0A8H7UBB3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBB3"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2173349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="82" mass="9057" checksum="B32D85FB517D7494" modified="2022-01-19" version="1">MQFTLHNSRNDKATCAPECVASHTTVGILEAKVSESVNRQTSITVKLPAQYRLVEPSNSRLTQQSDGRFNGLLDTRAIIRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBI3</accession>
    <name>A0A8H7UBI3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="4">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_005263</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBI3"/>
    <dbReference type="OrthoDB" id="15235at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000002">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GFAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="2"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="375"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="547"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2173843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="697" mass="77543" checksum="780448E6D01C239A" modified="2022-01-19" version="1">MCGIFGYLNYLIERDRRFILDTLTQGLSRLEYRGYDSAGISADGDNEDSVLIVKQVGKVAALRKLIDEQQVDFGKTFISHCAMAHTRWATHGQPSPVNSHPHRSDPTGEFTVVHNGIITNYKELKTVLEKNGYTFESETDTECVAKLTKYIYDREKSNGNLTFTSLVKAVIKELEGSFAFIFKSKHYPNEVVATRRGSPLLIGVKTAKKLKVDFVDVEFGNAAESADKITDANEPKNLDTNFLSPDGGHPKLQRSQSRAFLSEDGLPQPIEYFLASDAAAIVEHTKRVLYLEDDDIAHIANGELHIHRLRRDDGISSSIRSIQTLEIELAEIMKGSFDHFMQKEIYEQPESVVNTMRGRVNFQNHKVTLGGLKAYLATIRRCRRIIFIACGTSYHSCLATRAIFEELTEIPSQVELASDFLDRKTPIFRDDVCVFVSQSGETADTILAMRYCLERGALSVGITNTVGSSISRESHCGVHINAGPEIGVASTKAYTSQYIALVMMAIQLSEDRISMTERRNEIIDGLYRLPGHIKEILSDDAKLQQLAADTLYKEKSLLIMGRGFQNATCLEGALKIKEISYMHSEGILAGELKHGPLALIDENMPVILVMTRDSLYPKVQSALEQVTARKGQPIIICNTGDTGISAQYKTIRVPSTIDCLQGLLNIVPLQLLSYHLAVMHGVDVDFPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBU3</accession>
    <name>A0A8H7UBU3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_007827</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CEF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBU3"/>
    <dbReference type="OrthoDB" id="1410009at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11659">
        <property type="entry name" value="SANT_CDC5_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000021">
        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021786">
        <property type="entry name" value="Cdc5p/Cef1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047240">
        <property type="entry name" value="SANT_CDC5L_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11831">
        <property type="entry name" value="Myb_Cef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="11">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="54"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="11">
        <location>
            <begin position="58"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="110"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="196"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="730"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2177170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="817" mass="92072" checksum="111DF08D967F1E3E" modified="2022-01-19" version="1">MRVIVKGGVWKNTEDEVLKAAVSKYGKNQWARISSLLVRKTPKQCKARWFEWLDPSIKKTEWSKEEDEKLLHLAKLMPTQWRTIAPIVGRTPTQCLERYQRLLDEAEAKDSGELGLTGSVGPESGPSADDVRRLRPGEIDPDPEAKPARPDPVDMDEDEKEMLSEARARLANTQGKKAKRKARERQLEEARRLTTLQKRRELKAAGIELKPKKKKKNQMDYNADIPFEKRPALGFYDTTEEHNRPVDHTKLTNTHLSKLNQRKADREEEKERDKKRKAKDKQSTGGSEEGNKGNFVLASNMKKIQEAEQVAKRRKLVLPSPQVGESELEQIVKVGFAGQNAASLDEDGNAATAGLVGDYSITPSGNMPARTPRTTAAKDNIMNEARNLRALSAAQTPLLGEDNTPLAESQGTGFVGATPVRSEAQTPNPMMTPLRGKAGAATSELEQTPLRTPMRDSLKINEENGMVGQTPREEKMRMKQMRNSLKSSLAGLPRPKNEYEIRLPEMDEDDKQITNKPEITPDMAEVDKQEIELQEQQEQDRLRRRSQAIQKSLPRPVTIKIADLPKNATIPQQLIHEELVRLLEHDSVAYPVPGGKIAPGVQKAQNGLANIEDEFDNESLDQARQLLDEEVAQFLGVPAEEDVKKAIWDRIRADSDKFEDVWSKEHKDVLFSAEKMSFLTLDEFTDDKSKIAGLQKMLEANRQSMTQDATRAAKIEKKLNIVLGGYQARSQTLQKQILETFEQLESAESEHQSFINLQISEAAAIPRRIEALQKEVHFLTSKERTLQDKYKALATQKNEIVESILQKEQQQNAQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDL4</accession>
    <name>A0A8H7UDL4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RING-type E3 ubiquitin transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_001231</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 18">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDL4"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01923">
        <property type="entry name" value="cyclophilin_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16663">
        <property type="entry name" value="RING-Ubox_PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000079">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000014">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase cyp65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026951">
        <property type="entry name" value="PPIL2_U-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="13">
        <location>
            <begin position="38"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="301"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="470"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2175584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="61357" checksum="D087F2CF4E253C69" modified="2022-01-19" version="1">MGKWTDKLYITHAEWSGEVGQHSASAGSAGKRSSEGFKRLPFYCCSLSLQPFEHPVCTPEGIVFDLVNIVPYIKKFGTNPVTGEKLEAKDLIKLNFFKNDDGDFYCPVTFKTFSEHTAIAAIKTSGNVFAYDTIEKLNIKAKYWRDLVTDEAFTRKDVIMIQDPHNLENRDLSKFHYKKNDLKVVDAAAEREKKNPLNNINMTGTAARVLAEVTGKPVEANADKPSSPDTKVAKVTPKAPVSTIRTKAATPYNAAHYSTNQAAASLTSTAVGPVTINESELIDEEEFMYKHIKTKAYCSLQTNFGNLNIELFSDQTPRTCHNFVQLAKKGYYKGISFHRSIKNFMIQGGDPTGTGRGGESIWGAKFPDEIRGKLSHNDRGILSMANSGKDTNGSQFFITYRPCTHLDRKHTIFGKVVGGLDVLNKMEAIPTTEEDKPEQPIKIKDIVVFVDPYEDYHNKLEKRLIRQASGEYEKEKQERAKAQRAQDDAMGWFGPNKKKDSAKTVSSSVGKYMAEPSKKRDVIDDGLPQYVEKKKLKSTSKYGNFDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDU6</accession>
    <name>A0A8H7UDU6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetratricopeptide SHNi-TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_005507</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDU6"/>
    <dbReference type="OrthoDB" id="5587616at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019544">
        <property type="entry name" value="Tetratricopeptide_SHNi-TPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10516">
        <property type="entry name" value="SHNi-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide SHNi-TPR" evidence="8">
        <location>
            <begin position="178"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="102"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="351"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2176273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="382" mass="42805" checksum="9187B0F1F5E28ECE" modified="2022-01-19" version="1" fragment="single">TESQQPSPEIVSLIHEGSRAFSLHDYETSTAKFGQACELLDKQFGELSPQCADTYFMYGKSLLKYAIKQSSVLGNKAAEESTAIEETESHDSMCQFEEDATASNPRFHFEGEPDLREIEPEGEETGDNEENAEENEEDEEEGNQEGEGDEFNDAWDVLDIARVIYEKDDSPEAKAKLADVYVCLGDVSLETEKFDQALPDFRAAIDIKQTILEPDNRELAELHYKLALALEYSTSEQHLAVEETEKAVKVLRKRLEVLQDNQLAESGDKKGKGKSTESEVNQDAYQNTDIQKEIKEIQELIPDMEVKIEELKNPKQLEAQVDMLKEMLGLKGSTGGFPAVPVPANVNDLSSLVKKRKTDTAPSGQTHFQDEDKSKKPKMDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFE0</accession>
    <name>A0A8H7UFE0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UDP-galactose transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_008547</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFE0"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2180965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="39326" checksum="C9EDB2E41A05823D" modified="2022-01-19" version="1" fragment="single">QHLGLLTNLTGMAGSETLCGVQVRHLSLIALVFQNSAVTLIMRYTVAGLDKEQMYLPSVVVLMSELLKATTCAYMLSLYLPERSLLVIRKVIYQELFAKRLEMMKLSIPALLYLIQNNLQFIASSNLDPAVFQVTYQLKILTTALFSVLLLQRSLSNVKWLSLILLTAGIACVQISSTNDSGDNKRTENSIQGLAAVISACVLSGLAGVYFEKLLKAQNSGSKQKTDDLEKGKVHGMIIVPDEAQLWIRSLQLSVWSAFLAFFLTIVWKDGQHVYEHGLFRNFTPVVWFLVTVHALGGIIVGIVVKYADNILKGFATSLSIILSTALSVCLLSFSISWMFVIGTALVLFATYLYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UG30</accession>
    <name>A0A8H7UG30_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_003201</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UG30"/>
    <dbReference type="OrthoDB" id="3268246at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000057">
        <property type="entry name" value="Exportin-2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="27"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2177954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="983" mass="111379" checksum="99275AF2A8AE93E4" modified="2022-01-19" version="1">MEINDQTYGALQQYLRQTFDPSTQKQAEQSLAQVEVQRNFPLLVIKLIGDQSADPTTRFAAALFFKNYVKRHWVPDDENANKIALEDRAAVKAQLVDLMIAVPEKIQLQVSEAVSIIAASDFPDDWEQLLPNLIGKLSTTDYQVNNGVLQTAHSIFKPWRSQFRSDRLFMDIQYVLKDFCEPYKQLFATTDKLITDYANDKAALQVLSQSLLLLVKIYYDLNCQDLPEFFEDNMPYFMELLHKYLTYNNSNLETDDEDEAGVLEKVKSGICEIVELYTQRYEEEFQQLPTFFSTVLQLLSSTSQDPKYDVLASKALSFLNSVVRLHKHSNIYGTEDTLKQLCEKIALPNMALRTIDEELFEDDPIEYIRRDLEGSDSDTRRRAAADFVRGLMEHFESQVTAIFLGYIQHFLQQYTTNPDAYWKDKNTAIFLLTAVATKSGTAQHGATTINPHIDVIDFFSKYILADLQSPVTAGNPILKVDAIKYLYTFRHQLTKEQLVTVFPLLVEHLKSDNYVVYTYSAVAIERILFIKKVNAMLFTQADIQPYAETLLELLFKQIEKGQTPEKLAENDYLMRAIMRVIITSRQGMTPYVNIIMGKLTNILAVVSKNPSNPRFNHYVFESIGALIRFICPSSPAAVEEFENLLFGPFQVILAQDIQEFTPYVFQLLAQLLDFHTGKDLSEAYIALLDPLLNPALWEYGNIPALVPLVQSYLSRGVNTILARNKLTPILGVFQKLMASRQHDHYGFGILSAIVVNVPLDVITPYLRAIITYVLTRLQSKTSKSTGQLVHDKFTRSMLLWICLFLALDKQPGGADTVIEAFDSLQPNLFFQMLNLVVLPELQKVAEAKDRKTCAVGLTRLLTQSEKMLTDPYVGAWPTVLTALLKLLELPQDLAGDDLDELYTFDLEDTGYGATFAKLATAAPVKEDYVPSITDPTVFLAQSILALNQRHPGKVLALLQQSEGAGDFLPKYFKNANLDMAQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UG42</accession>
    <name>A0A8H7UG42_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_000400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UG42"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF348">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="3">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2184491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="475" mass="54485" checksum="2D64CE2ACB91925C" modified="2022-01-19" version="1">MDQIKSPVAKEPYTPPVNNHHTTCPVLASIAHFNFISAWVSTMIVMQSKLSRRGKVLEKFMHMAVALRNRNNYNTLMAVLAGINSASVLRLRHTRDWVSVKKIYKQFQSLERLMSTDRSFGSYRLALKASEAPGIPYLGIHNQDLLSLAEANKDFKLDGTIHWEKFRLMGDTILAMIRFQEPKFSIQPDAKILGFIAETELMNEDVRSVALGSPFLEEQFRQSTAIEPRLKATSTNRLRDLWFRVQTEIKYNPSTELVHMITADTVAQKPQVDSSDSTLDAVENLSIANNDETNNQSPLLRHKRISFKASPTTLNRRNTVSLADLIPAAAAAFNHDDMEFEHISQMSSLSRALTRVKTQMKTQRLKTTYLGKEWIRLALGLPVDESNVNCWRKPLYLREQDEDFDFTMVQKSNHGYRKQVKVANRIGRTFEIAAWYEWKRNPSTFDLQQVESKVERLRSLKLKLLTVDETNQTHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGD6</accession>
    <name>A0A8H7UGD6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGD6"/>
    <dbReference type="OrthoDB" id="2556122at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045226">
        <property type="entry name" value="Dsc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025390">
        <property type="entry name" value="Dsc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049:SF1">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN YOR223W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13373">
        <property type="entry name" value="Dsc3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="231" mass="26606" checksum="3E371293AC90BBDE" modified="2022-01-19" version="1">MDDDYYETTDLHIRWSNEQDLVFTVSPKESVASVKEKIQELAPRTSDKHIRLIYSGRILESSNTLSHYGIGKIQRAENSKAKIPPPPPTYIHCSVSDYRPENDTTETKNSQPQITPLMGFDRLREAGFTEEDIRNIRTQFHHLHGTTFDGENTEQTRTLEEQWMENTGETLPDGTLAGTYKEMVWGLMLGFFMGLICLFWFRESVFTRRHQMGIIAGILINLSFGVLHTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGI4</accession>
    <name>A0A8H7UGI4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein Red</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008411</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RED family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGI4"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039896">
        <property type="entry name" value="Red-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012492">
        <property type="entry name" value="RED_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012916">
        <property type="entry name" value="RED_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12765">
        <property type="entry name" value="RED PROTEIN IK FACTOR CYTOKINE IK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07807">
        <property type="entry name" value="RED_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07808">
        <property type="entry name" value="RED_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RED-like N-terminal" evidence="7">
        <location>
            <begin position="64"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Protein RED C-terminal" evidence="6">
        <location>
            <begin position="456"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="330"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="508"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="519"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2180832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="63206" checksum="503831035155AAB3" modified="2022-01-19" version="1">MSDQGLTQDDFRKLLQTPRAPSGDGDAPRSSGFKAPPPKTPRNVGATFAKPQSLKRKKYGSESKRKEGDEEEEEEEHEKSVDVNYRDRAAERRKEEGSGEVTTDGILQQLSEDGQELDPKAIYDQSKYLGGDTEHTHLVKGLDYSLLERVRREMRGEKDGNEVEEEAEDELDHALISSKIDQNEGDLATNNVGSEEKEDEVTVEDEIKSPFARRIYEKAVVDASKEKPLKNELFTAGRMAFVFELADDRGHYSSAFGIPTSIIRSKADIMHRGSRSSTDDLDADAQFVIGKVVQVIQSFKNGTNKVEVEPAPPPAKKFKREPSPQKIVAMDDDDDIFADAGREYELDEDEDDHIMEENKEQNPKAGKYFEGIAKDDMEEDEPEESEEQRKQNIAKILAASAAIHDTESKDEEKEKKQKESKFSDMQVDTDADDYNMFGLSAEALPSSFEDLKKSMAYDEGFEDSDGQRIPSSLIDAGTHRNKKAQLTRWDFDDEEDWQRYKDNLEVLPKSAMQYGVKMSEGRKRNREQRNPPNEKQKLDREWQKLKSFMDKKRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGT4</accession>
    <name>A0A8H7UGT4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGT4"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF11">
        <property type="entry name" value="ZINC-CONTAINING ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="29"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2181132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="338" mass="35825" checksum="5A8C0777B85327F1" modified="2022-01-19" version="1">MSTLSKAINSNLFTSMSRIVKAAVVTEFGKSPAYSDFDLPAPLETHTQVKVHAAGLHQLVKGRASGAHYSASAKLPMVPGVDGVGELSNGDKVYVMAFDKDSTGTMAQYANILKLDCLPIPSGGDANTIAALMNPAMSSWLALRTRASIKPNATVLIMGVTGISGQLAVQIAKSLGASRVIGAGRNQQILDSLLSKDLDVAITLSDDTEKIKQEIAKEAANVDIVLDYLWGPSAELAINSIIAARADKAQRLDWVQIGQMAGPTINFPAGVLRLANFYVSGSGLGSVSPPEFRSELGELVNKLVSGDFVAEIDAHKLSDVEHVWTRKADKGRPVFVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UH93</accession>
    <name>A0A8H7UH93_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_002171</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UH93"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000001">
        <property type="entry name" value="Cytochrome c iso-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 9 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="12">
        <location>
            <begin position="34"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2185736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="136" mass="14934" checksum="EE37196DF584EDD6" modified="2022-01-19" version="1">MYFSYVTLFCQFLVSSLHRTTLPTQSLKMPMPEGKAAAGAKLFKTRCAQCHTTEAGGPNKVGPNLHGVFGRKSGQAAGFSYTEANKNKGVTWDDETLFEYLLNPKKYIPGTKMAFAGLKKEQDRADLIAHLKEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHC0</accession>
    <name>A0A8H7UHC0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">COQ3</name>
        <name evidence="9" type="ORF">INT43_002263</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="4"/>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EC" id="2.1.1.114" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHC0"/>
    <dbReference type="OrthoDB" id="3265906at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="8">
        <location>
            <begin position="85"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="7">
        <location>
            <begin position="390"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="323"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2185826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="472" mass="53126" checksum="040818CC7EE6CA80" modified="2022-01-19" version="1">MLRTVFRSLRPAVVPKGQHVRALSQFTTIDAEEVKKFSAKSAEWWDPHGEFGMLHLMNPTRVSYIRDRVAPNNLGSTPFKGLRMLDIGCGGGLLSESLVRLGGNVLGADASYSNVQMANLHSRKDPSLWTGPGKLEYQNTTAEDLLSNGENFDVVLAMEIIEHVNNPSEFLRVCADMVRPGGKLLLSTISRTPMAYFLTNFMAEDVLRMVHKGTHDWSKYIKSEELVGAIHELPGKWKVDDVRGIAWNPLKGRWVLSEKNGDIGVAGINDLEVNYVLSASKPDVENRIHGAYRQPKRSTIQTIHQSNLMMDGLMDEYRPPTRLHHNRKKRGHVSAGHGRVGKHRKHPGGRGLAGGQHHHRINMDKYHPGYFGKVGMRYFHKTQNKFHRPIVNVDKIWTLVGEDVRNKYKNAEKVAVVDTLQHGYHKVLAKGRLPEQPVIVRTKFVSRRAEEKIKAVGGGMFTSILLLFILIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHN5</accession>
    <name>A0A8H7UHN5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHN5"/>
    <dbReference type="OrthoDB" id="6244550at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF1">
        <property type="entry name" value="DISHEVELLED ASSOCIATED ACTIVATOR OF MORPHOGENESIS, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="45"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="574"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="677"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2186216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1149" mass="126178" checksum="90E70AC76BA9A5E8" modified="2022-01-19" version="1">MISASTIASGTSSSFSAVGSATTPQSSYTPSSAKPSSGNPSGNPLKDLIETEKEYLDTLKILTNQIAPIWSNDQRSTDFTELLRHSHDIFKINKRFCARLVKISASPQGIRELGDTLMHWVNEMEAPYANYSRSFINNVNDRQDIVGRPALKTVLQALSSQQSYEITMESLINAPIQRLLYYKILYSRLLETTEPGRSDHQLLAQANKRIDTIMLMAKKNNPHTHVMASPSLHHVHSPPARQKSLPNAPPPIQTSFSSPYSPVQANTSHAAIMELERKIDSSTAVDVFSREPKKCRLQLSTAPRSIVIEDDFVLFPATGNAPPISCHVILLTDVLIITKFLTDDEMARAARAGSQYVYSLVFPPLALKHVQFRQLMPERESIGEFFLLIAIRNQDCMHLRANTREKKSLWLEKTNKQPTTPSQPTYHMQAMAANKPPAPAPKDFNSSSPAPKASPYPEQRSPLSSPGQNRDTIFDMYANIESSGYSKDESSSAPSRDTIFGMYTNEADDTPPLPKKKSNEAVKKSEGAAVTHEFIKPAVSHTLESIEVSSPVQPSSKGNFFDLPKIDRLNMDDSFSNISSSPPSTAASSVHHTRGSNEPESPLPTSPGLSAAPMFSQSVTNAYIAPPTAHNMEIAVSEVSEKPLPLQTIETGPVAAPILMHTALQHGQLPPLPPPALTASKSAPTTHLGPQQMLPPVPSPDPMFMNSGPSSNGSSLINGGPSGATSPHMRPRPSMNYGGPNYRPPPHMGPYGNAPPPGNPMMHGARPPPPSMMGRPPYPPGQRPMGHAPFPMSPQPPTSKAMGHRPPPLAMQPRPGMPPPGPRPMMHDGRPQDPMLRRSPTHGPPPPPPQGYLGGPPPSDNYSFLNVPPQGSPMGSPRSPTTASAMAAVREVLHRSPRCEVFRWKDNDWVAVENLCIVEIRQTVTNKPCLAVIIQESNHMYLNAWINRNMTPRQEAPTDVSISIDMGQGRKENYLIHCDDARDANALAAALHRTLMDAINAARREEEEMHAKQVSRTLSRSTSLGASSVRKPEDGPQTTKPLMQCRCKMFLQHEHASWTNLGSAGLRLSIQIPSQRVHVYIESEKDSKRLVNSFIQSNFVERVSGNTKRITFRLMNEQTRATAVYMVQVKDDKAGVKIYDYLKGNRTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIF9</accession>
    <name>A0A8H7UIF9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitobiosyldiphosphodolichol beta-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.142</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Beta-1,4-mannosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">GDP-mannose-dolichol diphosphochitobiose mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">INT43_008580</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13865"/>
            <dbReference type="Rhea" id="RHEA-COMP:19510"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57269"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="EC" id="2.4.1.142"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:13866"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.142" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIF9"/>
    <dbReference type="OrthoDB" id="614844at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004578">
        <property type="term" value="F:chitobiosyldiphosphodolichol beta-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="18">
        <location>
            <begin position="67"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="17">
        <location>
            <begin position="301"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG2180998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="486" mass="55762" checksum="237F837864BC895E" modified="2022-01-19" version="1">MGNFTFSEGGNWSIEGLALIFLIVYVLIGRIAKFYAFESNAHIFRSRPVVQVVVMGDIGRSPRMQYHALSLVDAGCQVDLIGYAETTPNIRVTLSRNIRIRPLRQAWSIPEGKPKLFYLLWAPFKALFVAVQLLWIMGGVTQYPDFIFMQNPPAIPTLVIAQFISWARNAWLVIDWHNFGYSMLAMKFGKDHRIVEFAKWYEQKFGHKAYAHLTVTDKMKAELTSWGVRGKLITFKDRPMAHFDKLTIERQHDLLARLKLEELIKSQNLNADEFVGSLDAETTILTQKENGVVKYRNDRIRMIISSTSWTEDEDFQLLLDAVSKYEDRARGQPTSKYPKLLFVITGKGPLKSHYEELISKMSLNRTRIITVWLESVDYPLLLGTADLGVSLHKSTSGMDLPMKVVDMFGCGLPACAVNFECLNELVHHGENGMVFDTSDELESQFEELFAQDGEKLKQLAKNVQEEYKNQSWEIQWKEKLPQLFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIU9</accession>
    <name>A0A8H7UIU9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIU9"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="4"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="362" mass="41529" checksum="C2984B3C1064CD05" modified="2022-01-19" version="1">MAPSSLPPEILQAILDKLLDDDTDYFADIIACSLVSRTWNHVVTYILSRSLNIVTLRGGQVENLVRLSGLLETIAENQITLPYSPDDIKTINLDMSYLFREDGTYDEKAQEVLIHLIEMLCTQTTGLELSFNHPVALLNWQEDRLKDFYQSLQQTTNLMDSVERLALQGLPRKDSAFVICNYGLSHLFPTFSPKLRSLEFANFPLRYAVYLLLQSCQELENVTFRDFRNLWEDGLIEAITHWSKLRSFTMTGCVHITPLVLHSLATHCPDLEELVVPRNLRYSKSCPDVNISMINLIENCPKLSKLDLSNYESIDDNLLRVIVEYAHNLRYLNLQNFWLSSRQYSHIPTSAPQANPLYNNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJ23</accession>
    <name>A0A8H7UJ23_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_008428</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJ23"/>
    <dbReference type="OrthoDB" id="26094at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="12">
        <location>
            <begin position="38"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="11">
        <location>
            <begin position="199"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="265"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2180849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="305" mass="34518" checksum="9A7E97DA0FDAD10E" modified="2022-01-19" version="1">MEDETRPELDSLFEDDPGSLAEIGEEDVDDLDISNVGTKIWLVKVPNFLAEKWKNVDQDSMNLGTVRIYNRQVNTICQVKLILPDNDMTSDIPKEYSIKIPSGEVENKYVFAGNQHGAATRVVGKIHHECHVSPANWKTYRDIMRKRVHEADRPTRSVQILGQSSQPVFAPGASSGMPASDFSSFIPSKKPRIDKEKATRMPRNELMDMLFAAFERYPYWSLKGIVEHTRQPMQYLKEILSEICILNKRGPYTSMYQLKAEYKVRGADNRPRTEGTSEGGAGGDGSEGDFSSDDEEDEEDMEMVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJ49</accession>
    <name>A0A8H7UJ49_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="5">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_008489</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJ49"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000004">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="9">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="99"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="8">
        <location>
            <begin position="547"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2180909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="663" mass="73265" checksum="3F8C4FEF96EADAD7" modified="2022-01-19" version="1">MSANPDQVDTTSRVDPIHPVPSRLLDPAQCPTPYVSSFDQYKTMWKESVEQPEKFFGNLANELLTWSKPFETVRHGSFQEGDVAWFLEGELNACYNCVDRHALKNPNKVAIIHEGDEPDYVKKITYGELLQEVSKLANVLKARGVKKGDNVAIYMPMIPEAIVSLLACARIGAPHSVIFAGFSAESLRDRVVDASAKIVITADEGRRGGKNIATKRIVDDALKACDSVSNVLVYQRTGSEIPWTEGRDLWWHEEMAKARSYCAPERMNSEDPLFLLYTSGSTGTPKGVLHTTGGYLLGAAATVKYIFDYQENDIFACMADIGWVTGHSYIVYGPLTLGATTVLFESTPTYPTPARFWELIAKHKITQFYTAPTAIRALRRLGDQWVEGHDLSSLRVIGSVGEPINPEAWDWYNEKVGKGRCAVVDTYWQTETGSIIITPLPGAIATKPGSATFPFFGIDPVLLDPASGKELEGNGVTGVLAVRQPWPSMARTVYNNHSRFLDTYLKPYPGYYFTGDGASRDIDGYYWVRGRVDDVINVSGHRLSTSEIESALVLHHSVAEAAVIGGHDDLTGQCIHAFVTLKPNVEEAEGLEKELSLQVRKIIGPFATPKRIYLVSDHPKTRSGKIMRRILRKIVNAEHHELGDTSTLADPSIIPSLITKVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKK6</accession>
    <name>A0A8H7UKK6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_007231</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKK6"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037830">
        <property type="entry name" value="ZZZ3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705">
        <property type="entry name" value="ZINC FINGER, ZZ DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705:SF0">
        <property type="entry name" value="ZZ-TYPE ZINC FINGER-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="7">
        <location>
            <begin position="497"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="197"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="396"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="48"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2182304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="579" mass="63705" checksum="F29CF742580AA0AC" modified="2022-01-19" version="1">METNEDTQVQDADAIMHENITPVAASSGMSTSDKSANALAPQDGKQAISQMEQKALQENEDYQAIQKALTILRYQLEKARKDVKVLVQMKEEAIAEPIEFVNRLKRKIKLETPPLQKVVCVQEVDWSKFQVPPEGRVASQLAKLAAVTSSSSSFDHRAVFKNILEGPTPSIRDRENKDTSHAKITAELDRAANAMENVGSNNATATPSRATSVSEMSDKESDDESMANTKSGKGRGKRRASAVGLFNRHLQDPPSPTSSTTSNHLSADELTPRSLLQKSSWLSDTSQYESPSRHRTVSPELSHKLRDNVDDENKPVTHNLPWSDEEQKRLEELLVIYPDEPVQAQRFNKIAAALGTRTARQVGSRVQKYFIKLAKNGLPVPGRITIPAKVHLCQPSSLPKAQRPNQKAKSDFKKPNPKARADSDTTVRRTGTSYNVHLPGSTSSVRVSGARYITENPSPSVMMADNDLDTSLMMVGSGAYSSASQKPAVNEHGEAIHYGFACDSCGDEPIVGARYKCTQCDISEEVDLCEKCHEKGTFTNDHHPLSHQFEAISTADPLPYYADDDYAGDSHLGEFDYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKN5</accession>
    <name>A0A8H7UKN5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">D-arabinono-1,4-lactone oxidase</fullName>
            <shortName evidence="13">ALO</shortName>
            <ecNumber evidence="6 13">1.1.3.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">L-galactono-gamma-lactone oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_006313</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23756"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16292"/>
            <dbReference type="ChEBI" id="CHEBI:58277"/>
            <dbReference type="EC" id="1.1.3.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Cofactor biosynthesis; D-erythroascorbate biosynthesis; dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; L-ascorbate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.37" evidence="6 13"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKN5"/>
    <dbReference type="OrthoDB" id="610608at2759"/>
    <dbReference type="UniPathway" id="UPA00132"/>
    <dbReference type="UniPathway" id="UPA00771">
        <property type="reaction ID" value="UER00766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019853">
        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030654">
        <property type="entry name" value="Sugar_lactone_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01679">
        <property type="entry name" value="bact_FAD_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01678">
        <property type="entry name" value="FAD_lactone_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF1">
        <property type="entry name" value="D-ARABINONO-1,4-LACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000136">
        <property type="entry name" value="LGO_GLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0060">Ascorbate biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0274">FAD</keyword>
    <keyword evidence="7 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="14">
        <location>
            <begin position="25"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2183308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="456" mass="51987" checksum="D2281C8E0A441C3F" modified="2022-01-19" version="1">MQSLSVDLQKIAKEGHHFRNWANTFGCSPELYFEPSTEREIVEIIQLATKNKKGIKVVGSGHSPSDLALTNDYMISIHKLNRLLAVDNDKGIITVEAGMDLHTLHQVLKNNGLALSNLGSISDQSVAGVMATASHGTGTGYGSLSTMIVDLTLVNGKGERLFCSTTSNSDVFEAARCSLGALGVITRMSLKVEPEFRLEAKQVPAKFEDVLQNWDTVTNSAEHVRVWWFPHTQDCVVWRANRTDKPVSNNPPSWLKYTFVGFHVYQFALNIARYRQSMIPSLTKFFYNNVHSSPTEVVDESYKVFNFDCLFPQYVNEWAIPLEKAPEALRRLDNFINTSELKVHFPVEIRFVDEDDVWMSPSFGRKTCYIGVIMYRPYGKPVPYKKYWRVYEDIMRSLGGRPHWAKAHGQTVDDLEESYPKFRDYLQVRNQMDPNGLFVNKYIERHIVGKQPMAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UN71</accession>
    <name>A0A8H7UN71_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UN71"/>
    <dbReference type="OrthoDB" id="2262177at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2184974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="375" mass="41382" checksum="C35D4D1123EE738B" modified="2022-01-19" version="1">MGWQFVFLVVLRVLVFVVTCLALACHIANIVLLVNYTKVISIAPWSKNIPYILYLVALGVSFFSSLALLYLTAARKKTIIGDKVLGIINTVIVAAILIYNTIKSGPEPWLDNTLTFAAATHPGWIPYCSAFNGGVKMGSNLFMRCWLINGLWLGMIICCAFWVALGIFAWTQHTHDVYDDNDDYHYKSDVPLVPVPSSQQSYSHAYSNEDPYDRSMTTSPAAKAAATYGGYNDSTPYDGYNNSAKPAYADYNSSAKPTYSEYNTPSSGRAYGGYDTRPSERSEGYYDNYIPYRSQDNNTPGGQTTNSSKFENEDTSVYGTPRSNPASPGLYSNHNNMRYGGGSPGYGNAYGGTQSNAYDYQRNNSYAKSNAYEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD49</accession>
    <name>A0A8H7PD49_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD49"/>
    <dbReference type="OrthoDB" id="2402378at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="387"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="457" mass="50982" checksum="5A07276FD217E4EF" modified="2022-01-19" version="1">MNDFDITSFRSKPKKSGKKQRIRDPNEVTTSFTKYLEKRKALGLDDSDSDSNSDTDLKRKTKKQIPLESSEAVTSVLNVSNASTTDPPGPDIKHFPEVAVKTNSPSVTAETTLKKTIQDSKIMYVIVKISIRIITMLTISWFPCSISLDSDEDEEPSNSKAIDKPATSEGSTIPTPVESNSSKAANNDSGSLSQTSISKHEQSSLSLLEDFDDLDPDLAQSFLEASPEHSFYETSIEESTPQKIAVKFHMRLYPDAASENKSPTPDEAQIRKVLKILVMDREPLELAIHAFACHKHYKLEELIFVYNNTKVWPIATPAGLGMQADRDNNIDVYLKDTWAKKLEREEQIKQERLTAQMKADAEFSDGEAGDSQTGSGTVQDTENNSGMLLKVRGKDGHDTMMKVKPTTTIAAIIKHYRNLNNLGDVQVKLLWDDLTLDDNEQVQDTDLEDEDMISATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD59</accession>
    <name>A0A8H7PD59_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD59"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31964">
        <property type="entry name" value="ADENINE NUCLEOTIDE ALPHA HYDROLASES-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31964:SF113">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="83"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="178" mass="19735" checksum="595CBB82FE0EB452" modified="2022-01-19" version="1">MSVPLDQRRRIAIAYDGTEDATKLFKWAIDNIFRPQSDHIILLSAVSGGEQRRGSITSNGGSPRRRLSLPMTSARPSEVNEMLNDPSHKDLAASDVAKQRLQDMARELHTLNATSEEHILWGDPKVLIPKFTTNHSVDLLIIGSRGLSKVRKVFVGSVSENCIHECPCPVLVVRNTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDA7</accession>
    <name>A0A8H7PDA7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_008190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDA7"/>
    <dbReference type="OrthoDB" id="308861at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="134"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2171810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="216" mass="24796" checksum="555ABBCCD995B587" modified="2022-01-19" version="1">MDKRMSAEVAGDSIGDEFKGYVFRISGGNDKQGFPMKQGVLLPHRVRLLLSKGHSTYRPRRTGERKRKSVRGCIVSSDLSVISLVVVKQGEQDIPGLTDTAVPKRLGPKRANNIRKFFNLDKTDDVRKFVIRREVQPKNPEKKPYTKAPKIQRLVTPVTLQRKRRQQALKRRRAEASKEAEANYKELLAKRVKESKERKQEIKRRRTSSMQKSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDI5</accession>
    <name>A0A8H7PDI5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDI5"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000016">
        <property type="entry name" value="TBC1 domain family member 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="354"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="705" mass="80033" checksum="CE6A706F868E0B8B" modified="2022-01-19" version="1">MSLHVPMDDKPNQDAVSPPPTPSKPLHRMRLRSSSFTLRPADVIRRQKSDSSFHTHFTGSRIGQENARRPSYESKTMAGPPKSRLSTNTYQDDDSTRLPTAQDMIDMHGNSSHDSGSEDDEPPVPVSKNDNQPSDIKPNGFEGLFMRKATRTQSQSVHLSPMASNAPQRSKSTNLMKAKPTMQVALPLPPKPIPTASSPTSTSLSTKTSSSSLSSSLRSKLGSRKTATSSPSSLMPPTPTIPRRNSSMRLVNKKNAQEAKSRVSTEKEQTELYDDGSQAVYPPPPPKDTCDDERDQYGFKMSSQWLSVEDYHEHDKLYQPIVDRRAQKWHQILAENDGKWPEPSSKFKRYVRKGIPADLRGEAWFHYSGAEAKYHANAGVYQEHVRKAEEGKDENEFCDIIERDLHRTFPENSKFKSTTDNADGSTSMSTEDIPAIMALRRLLFAFSVYCPHIGYCQSLNYIAGMLLLFVEEEKAFWLLVTIIEDILPAGIYDITMEGANIDQTVLMMFIWERLPHIWNKISTSRGFWECEKDVDGASMPTITLVTSHWFLTLFINILPTESVLRVWDCMFYEGQKVLFRVALAIFKLNEQKIMDVDDPLEVFQVVQNMPKRMLDCHRLMETTFRRLGSATDITDADIERRRELFKSRRKERRKTNINTDDIGTRRTKVRGTIIHKAMEARRLVERTKSLKHGPKGAANDSKIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDI7</accession>
    <name>A0A8H7PDI7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008074</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDI7"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009396">
        <property type="entry name" value="PRK12756.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF20">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="7">
        <location>
            <begin position="47"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2171694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="365" mass="39733" checksum="48FD9FA9F8F95A48" modified="2022-01-19" version="1">MSGNIALNDLDDKRIKEIRPLIPPQILVEDIPLSLKAAQTIIEGRESAERVIKGLDDRLLVIVGPCSIHDVTAAKEYAEKLIAYNETCKEDLCIIMRVYFEKPRTTVGWKGLINDPELNNSFQINKGLRVARQLLLDLNEMGIPTGCEFLDTISPQYTGDLVSWGAIGARTTESQVHRELASGLSCPVGFKNGTDGSIGTAVDAIKAASNGHHFLSVTKQGLSAIVQTEGNDSCHVILRGGKTGPNYEASEIKKTCAALEKAKSSSFVMVDCSHGNSSKDHNRQPIVADSIAQQLAEPKETGDNIIGVMIESHLVEGRQDIPSEGPHRLVYGKSITDACINWDNTVTVLDRLREGVRARRAARQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PES7</accession>
    <name>A0A8H7PES7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PES7"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="22864" checksum="79409A35CD5FD5EB" modified="2022-01-19" version="1">MSTTSSNVPSSASATATDSGTASQYLDGFTGMSGWSEAARWAINAVVIIVVVIASAFFYYRYRKLRRLADSRQLSHVATEDTRRATEPSADDDLTLLDHEQLAILPVSKYDPDKVRNSTCPICLEDFEPTRRRRHSNESLPPSLSETDMTDSIISKPPSVASMSRTSQPPPFNDNYNEPAQASSRPVKRFIRRLPCGHGFCVTCIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PF01</accession>
    <name>A0A8H7PF01_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PF01"/>
    <dbReference type="OrthoDB" id="10265539at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="293" mass="32750" checksum="6343EFB9DFC739A0" modified="2022-01-19" version="1">MPLTDVQYLNVYITVTSACFAIAIKCTFEAIGFLMDRQARLQILCFICCVCGTINCGLTLFFTIFPSGFCWWFRIGGSFYEASLISTTFIMVFRANAVIPMVSSTVRLLFWIFSIVMITAQISIGLVITITTESTALMNDACSPLLSSQVMAGWYGSIILPAIVLTTIFSYSLMKANQHRKESFFRTVLISSGASAVLAGISQVTFMLLLAFSMLPPKYSLMLVKSDLTIHILITVTFVRRLMKESNSQGPITRRNRIDPGLAELEIQSNRVPFETVRPTFEIPKPSRIPTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PF78</accession>
    <name>A0A8H7PF78_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase catalytic subunit A</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_000130</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PF78"/>
    <dbReference type="OrthoDB" id="1676488at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055082">
        <property type="term" value="P:intracellular chemical homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000052">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005725">
        <property type="entry name" value="ATPase_V1-cplx_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="27"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="16">
        <location>
            <begin position="130"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="14">
        <location>
            <begin position="236"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="17">
        <location>
            <begin position="468"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2172783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="619" mass="68669" checksum="6A9A667A667315EC" modified="2022-01-19" version="1">MAGALENAQNNLRKIKDHERESDFGLVYAVSGPVVVAERMFGSAMYELVRVGHHELVGEVIRIEGDKATIQVYEETGGLTVGDPVLRTGKPLSVELGPGLMSNIYDGIQRPLKAIQEVSQSIYIPRGISTPALDKAISWDFKPINFQVGDHITGGDIYGKVYENSLVSVHHIMLPPKSRGTITYIAPAGSYTLNDTVLEIEFEGEKSNFTMLQLWPVRAPRPVTEKLSANEPLLTGQRVLDSLFPCVQGGTTAIPGAFGCGKTVISQAVSKFSNSDIIIYVGCGERGNEMAEVLMDFPELSIEINGRQESIMKRTTLVANTSNMPVAAREASIYTGITLSEYFRDQGKNATMMADSTSRWAEALREISGRLAEMPADSGYPAYLTARLASFYERAGKVTCLGNPQRQGSVTVVGAVSPPGGDFSDPVTASTLGIVQVFWGLDKKLAQRKHFPSVNWSLSYSKYMNVLEPYYEKADPEYSTLRNRCKEILQMEEDLSEIVQLVGKSGLNESDKITLEVAQIIKDDFLQQNGYSNYDRYCPFYKTTWMLRNMVGFYSHALHAVEVSNNQITWSKIRESMGDIIYKLSSMKFEDPAEGEQALSAKYSELNKEIESRFRDLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PF79</accession>
    <name>A0A8H7PF79_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_000168</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PF79"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF666">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="502"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="573"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="607"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="243"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2172818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="647" mass="71394" checksum="1E035D7CCAF8FC8A" modified="2022-01-19" version="1">MNPTMQLPVEQVAKVVRRHLVTQRDSDASEDADHAHADHSEITVHDTNQPHHGDSHSIDSTIRNAYKLPGGSIVDGIYKWTAHVESERKQRLLRSQSISFPIPEQSSTHDLSQRLKQPGGFRRHYVLSKAAKQGRKPPNLWTNSFAEFLCLYGHFGGEDLSDDDELESSSDEDEEAVIGYGSSILNEASSSKTPSLNRTASTSYKRKSNHDRAAIASTSGRRRTSEATPLLSKPKNNPPAGGTATPAKAVFLLLKSFVTTGIMFLPKAFYNGGLIFSILGMIFIAAISLYSFLSLVETRTAVPAGFGDMGGVLFGSKMRMAVLICITLSQIGFVCAYMSFVAENLQSLILTFSKCRVSIPLHVLILAQCFVFIPLAMIRKIQRLSVFALIADVFIVIGLMYLYYYDFYTMATSGVADISFFSAERFPLFIGTTIFTYEGIGLVIPITEAMKEPKRLPQVLWRTMAFITLLFSTMGAISYMAFGDNVQTIVLLNLPAKDPGVSTIIALYSLAICLSIPLQLFPAIRIMENGLFTTRSGKNNTIVKWEKNVFRVAVVFMCAWVSIVGSKDKLDKFVALVGTLFCAPLCFLFPPLFHLKAAAKSYLRKCADVAVMLFGLLCMLYGTAMVLVQWNSSVGIDPIKRCIARST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PF91</accession>
    <name>A0A8H7PF91_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_004772</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PF91"/>
    <dbReference type="OrthoDB" id="268928at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2172231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="177" mass="19841" checksum="45B65EC7041CEE67" modified="2022-01-19" version="1">MSNYWDQRRSIFCFKIPNPFRLLGEKQRAVGVYAAGAFFAIGWWAFIDAITLASKDPFKQVSIGFEDWISGILTTLGMLVINLIDKSSLHGETFSYSGDSLVWKARLFLFVGFALIAGGLAGSVCVLILKYIVTEVPDSDLYYGIGQVAQCGFIMLSTVILWIAQNTQEEYQYNFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFE3</accession>
    <name>A0A8H7PFE3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_000022</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFE3"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF41">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="541"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2172675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="580" mass="66469" checksum="FA2B38E804C4C440" modified="2022-01-19" version="1" fragment="single">ALLLGAVSADEHNHVYDSKEEVVVWMNTIGPLNNWQETYDYYQLPFCHGDSPVQHHHETLGEALQGMDLINSGIPMSYLTSADHELICKTTLHHREIDLFKYAIHNNYWYQMFIDDLPLWGYVGRIQSHNEDGTALTTVIEYINTHKIFTIGYNEDRIIEVNLTDANPVPLDSSQETIDLEFTYSVEWVPLDKQFKDRFNRFLDADFFEHKVHWFSILSSFMMVLFLTGLVAVILLRTIKRDYARYDKEDGLGDFDRDIGDDYGWKQLHGDVFRQPPKLMLLSSLIGIGNQLIILSAVVILYTMVGDLYVERATILTATIFLYALTSGVAGYTSASYYAKYGGQDWIRTVILTASLWPGAVTIIGGFVNAVAIYYSSSRAIAFSVMMAMVAIWVFLCFPLTLLGAIVGKNWAGQPDFPCRVNPIPRPIPEKLWYAEPFVVIACGGILPFGSIFIEMYFIFTSFWTYKIYYVYGFMFLVFAILIVVTACVTIVSTYFLLNSEDHRWHWMSFLTCASTSAYIYLYATYYFFTRTRMTGFFQTSFYFGYTGLVCLGMFCLLGAVGHYATSQFVRKIYQNVKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFN5</accession>
    <name>A0A8H7PFN5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_004460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFN5"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF112">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G02370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="75"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2173087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="284" mass="31443" checksum="F2F1E9036FA885B4" modified="2022-01-19" version="1">MLWTHLIRFVAKEDSNVYLGQLVDTVRDIGLDSFTGTAIKAYRIDGSIFDGKVTDKLLTVDRLLSPITREQCDYVRCVGLNYKDHAEEAHLELPKVPILFTKPRSSIIGPYPDNVNIPKCAQDNTSDYEAELCVVIGKTGRDIKEEDALDYVLGYTASNDISARKLQLTQSQWCFGKGLDDSLPIGPVLVSPRAIPDPQKLGIKAIYNDRIVQNGNTSDMIFSIRQQIAYFSQGTTLEAGTLIITGTPAGIGIARNPRVVLEDGSDIRVEIEKIGTLINKVHYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGJ1</accession>
    <name>A0A8H7PGJ1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_004664</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGJ1"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF160">
        <property type="entry name" value="ERAD-ASSOCIATED E3 UBIQUITIN-PROTEIN LIGASE COMPONENT HRD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="4">
        <location>
            <begin position="9"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="472"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2173290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="544" mass="59713" checksum="006DCB081C53A9C7" modified="2022-01-19" version="1">MSLIADEQLHTNTYIWSQEKDQVTISFLVPEHCKSKDLDIVIEQQQVKAGLKGQEPVLKGKLYAPIDHFTSLWQLEKNNATPSSNPSSLTASPSLSIASSFAFLSPAHSPNSSVILPAPALTESMTFDTSSQHAIDPSSLPPSLPSSAENSQPNSPISSTTPPPAFAQESSKKYRLLTLHLEKEDQNTEWVVPVSGGYQGNEMDMDPTSAYHLAGWFETRMRDAERAFKHYEMAAEKGHTRAMLKIAAMYEVGKESMEESPVMTPVYPSRDATKAFEWHKRAADGTVAADGTTIGPSDAEACYIIGTTYAAGSEEAGVEKDYDLALMYFQKCMLTTAGHIDFDFSHADDPNDPGLQRKPLRSYQPHTRDERYFCSAAFQAGLIFLGGAGDQDHASHHVNEPNPGLAIEYWKQSAMLGHAQSCFNIGVMYANGMGVTQDVWEAGRWFGRAKKLDGIGNLEVPPGVEVVEWHADRSSDHPNKQANDSAPVGASSSSSAAKRRKKKTKKRSRQQRQQDQDTLKLIVGVGSLVAVVSVITYFVLRKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGP6</accession>
    <name>A0A8H7PGP6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGP6"/>
    <dbReference type="OrthoDB" id="2381376at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35814:SF1">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="416" mass="46770" checksum="83049F233193AAB2" modified="2022-01-19" version="1">MSQDSPLARLRDFAAEYFPEIIAPREPTLKEKVEAKAEQVKDKAVDGLLDAERTGTHEIKNFKQAINEKLHGLVGDGAQATDEARAASHQNLKDLKKDVNAAKQHAKHAVADAKKRAEYAKQHAQEVESSADDSVSESKAKVAEQVQDVKEKINIWWSSAKNSLDTENLRQKLEERQEEEREELFLAKGAEQQDIEEFNARALRHEAGFVDVPLERRKSVPSGISLYERSQHYLDGHLERRTLGEHVQYAPLTGVYGGVFLLYFLILTVRLWYQRRKTDVYVGDGTIERYKADKESTNGTIGRKLRRTFEAPSPSQYERVSRLSDAYNTLTTAVPISLLLIGIMELNGYPRHLLHYVLGSLVFGAALATEFGVLSSDPSDLAAYGRREVGQLVMWGVMVFTGVSMVVIVWAKAFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGV0</accession>
    <name>A0A8H7PGV0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGV0"/>
    <dbReference type="OrthoDB" id="2470731at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034053940" evidence="1">
        <location>
            <begin position="22"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="176" mass="20081" checksum="04C780A3EF2E2C9A" modified="2022-01-19" version="1">MKGLVLPCMLATLLSAQGALAATFFKSGTYGISPAISRPEYLGAEYTNVTIAPYPFFWSVEFSNGKWTIQDKLSMGYLAADRNQEHGSRVDVAFDPYEWQIEEHDRREGTWRIVRPQSPNHPSYGDISVLTYDDIQDPNGDIFSSKNQDYISVQHLRFDSRPNIVQYWRFTQSTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGZ2</accession>
    <name>A0A8H7PGZ2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_005212</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGZ2"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="11"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="262"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2173792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="420" mass="47191" checksum="44DE311CBBD3F2E2" modified="2022-01-19" version="1">MAKEATNEERDQFFKDLRHNRHNKLCFDCSARNPTWASVSFAVYICQDCSSVHRNMGVHISFVRSTVLDTWQWEHLYLMSAGGNQAAQEYFSKHGVSSLNKDSLTKYTSKVAQQYKKQLLSRAKQLQESRSTSMDSDREVSLIDFSSESQSQRKTNNLSKEEEDFFSGWEAPQATTATHGSATQAKIAPKLKANLSTVSQSRYHKAKPMKLGAKKHADFNFEEAKQREKLAAILPEEDMIKPIDQPQARPTSSRLIYDDAFTSKQSITPDSSKPAQRRTSNDAPRRFGGFGYVPDTASQTQTAPVALRITGMVSTTSNIDEPTGARDRFSNAKSISSDQYFQRGNYDPTQNAENSARLVQFQGSNSISSDQYFGRPEFNAADVKSPADVDASELTRKFLRGAARGASKLQRMLSDMERRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHL1</accession>
    <name>A0A8H7PHL1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipid droplet-associated hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_004152</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. LDAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHL1"/>
    <dbReference type="OrthoDB" id="448051at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2174132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="36341" checksum="D7D5B40304464E15" modified="2022-01-19" version="1" fragment="single">MNQKLLPLLQTPLKAVWNVAGNLTDTCYWPSSNTGKKIVLMLIPGNPGMVDYYDNFCEVIHKNLADNSDLSLEIIAGEYLASLSLDHVLRIMTKLKLGLVSHLGHSNRTSNPTNRLYSLQEQIQHKIDCFDTVRKQCDSDTKFVLIGHSVGSFICTEVLKARPKQNIVRLIALFPTLQHIAKTPNGVALSPFFPAIPRNIISCSVSLISWMPPFVRKTLVGAITKQPDPSLSVTADQLLNRTVVNNALYMAGQEMATIQALDYDFYNAHVDKFIIYFSPGDNWAPKHHYDDMKNSFPHADISLCEENLPHAFVLEHKHAASMGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHN4</accession>
    <name>A0A8H7PHN4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sterol 24-C-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Delta(24)-sterol C-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_004158</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of methyl groups from S-adenosyl-methionine to the C-24 of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Steroid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHN4"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000019">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000003">
        <property type="entry name" value="Carnitine acetyl transferase FacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF29">
        <property type="entry name" value="MITOCHONDRIAL CARNITINE O-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="8" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="10">
        <location>
            <begin position="77"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2174138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1067" mass="120933" checksum="69C26677F700AF6F" modified="2022-01-19" version="1">MSNGVVSTSHSEDLAFSRALHGNQVKEGFLSNMASKNKKVHDSATGDYLSLWKKPENETEEDEKKRLDQYTQLTNTYYNLATDFYEYGWGSSFHFARYYPGEEFFKAISRHEHYLAFKMNIKPNYRVLDVGCGVGGPAREIAHFTGAHITGLNNNDYQISRAFHYAKREGLAEQTDFIKGNFMEMPFEENKYDAVYAIEATVHAPRFEGVYGEIYRVLKPGGAFGCYEWCMTDDYDESNSEHRRIAHGIEIGNGIPKMRKISECLQALRNVGFEIEVHQDLADVGDDIKWYYPLEGDWRKCQSARDYLTTAAMTKIGRFTTTQLVRTLEMVGLAPKGSYDTQKFLETAADALVEGARANLFTPMFFFVARKPESSPHLSPDPIGGLTFQSQDKLPKLPIPNLKETCDKYLAALVELQTPKEHEATKLAVKTFLESEGPALQEKLQTYATDKKSYIEEFWYDSYLQYTDSVVLNLNPFFLLEDDPTPQRSDQVVRAASLITSTLKFVSALREKAMEPDVFRGIPLCMSQFGRLFGTSRMPTENGCYIQTEDEARHIVVLAHSQFYHFEVFDEDGNIAVTEKEIVANLKAIRADAAKTPVHEIAKNAVGVLTTESRPNWARLRDELNKGEENREALHVVDSSLFIVCLDHVSPKTSDDLSTNMLCGSYEIDQGVQVGTCTNRWYDKLQIIVCKNGSAGINFEHTGVDGHTVLRFVSDIYTDTILRFAQTINSQTKSIFHSVAQNEERRRSSGTSTKSGALPLQDLNPRKIEWKLNKELNLGIRFAETRLSDLIQQNEVNVLEFDEYGKSFIVDMKLSPDAFVQMAFQAAYYDLYGKIECTYEPAMTKTFLHGRTEAIRTVTPEVADFVKKFSERDDDNRVVLDALRKAVSKHSKLTRECSKGLGHDRHLYALDCLWQRLNKDQGTPTPKIFTDSGWKTMNHTVISTSNCGNPALRLFGFGPAVGNGFGIGYIIKDDGIALCVSSKHRQTARYLDTMKKYLREIKHMLMNEKYPTGTSQRQRLLAMQENASLTNGYGYWDIDSPSERSPTPDIKSMKKVGRRLMLNDVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHX7</accession>
    <name>A0A8H7PHX7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_004311</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHX7"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF392">
        <property type="entry name" value="HAP41P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034865344" description="GH18 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="37"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2174288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="526" mass="55723" checksum="9DFAFCE71700B6DE" modified="2022-01-19" version="1">MKISTLLASVACSAVLLANSIMANPIGPYNKRATTNNVNVGYFPNWLYSRYLPSQIDFTKYTHINYAFAVQYQGNTPQWADSGVLDPSVQYGLPNLIKLAHAAGTKVLVSVGGWSGSVAFSGMASNAANRAQFIQWNINFIQQYGTDDWEYPTSTGAGCNAVSANDITNFASLVQEMRAALDSNFPNVHKELSLAVHLTPWGGATIVDDATSFVPYVDRFHVMSFDVNGAWNSTSGPNSPLHNTPGYGYPYGLVEGVNSWIAAGVPANKIAAGVAFYGRAQTTTVSSTTTQYNPAVVGAPLGDSLDAPWQDAYCSSDYQSASGVWRYSYMRSQGLLTSPTTAGSPWIRNYDSVTQTPWLFNPSNKQYISYDDPTSIAAKANYALSAGLAGLFCWSLDEDNGELLAPMAAVIANNPPRVPITTVLKGTATTTTAVKTTTTSAKTTTTNKGTTTTTAKTTSTKTTTTATSTSTSTSACTAANNGQMVCTGTNTVGFQECVNSAWVNFSCAPGTVCQQSGSSIACGYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJ00</accession>
    <name>A0A8H7PJ00_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_005905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJ00"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2174843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="79" mass="9356" checksum="E2E95C166D616009" modified="2022-01-19" version="1">MLISRAFEYPTLRSCTELAVFTVPAKWCKTYHDELRSELRSECKYRQFLRRAGNCVLSWMTGQETKFSACLWIIIDEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJ17</accession>
    <name>A0A8H7PJ17_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJ17"/>
    <dbReference type="OrthoDB" id="2286748at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2174181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="188" mass="21454" checksum="AEF46F58A5AA3B9F" modified="2022-01-19" version="1">MPAIIKRETPIAAKSRKSGRVIKKSARSPPAQWIKSRESSPEADKNTTNIKRLEKELAFSNDTLATIVVMIESLQRAYDSRRPDQPMEGRTRLNAAERELLAEYDDLDLQMSHLEKKISAMETALSQLKGGAPSCTDIKIEQIPAMQAVDQWQHLQYFPSEQDASLSPQQLELKVEELADWIDWTREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKH1</accession>
    <name>A0A8H7PKH1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_001354</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MPP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKH1"/>
    <dbReference type="OrthoDB" id="445326at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012173">
        <property type="entry name" value="Mpp10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04006">
        <property type="entry name" value="Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017300">
        <property type="entry name" value="snoRNP_Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="127"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="543"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="127"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="216"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="554"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="567"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2175707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="621" mass="70991" checksum="9B71DC0D93A5BD00" modified="2022-01-19" version="1" fragment="single">MVSTRRNKDTKTKSSILDTFVSDVIEKPQIFFAKDEQSAAKAIAVAKNLYDTAKKVEAVQLSPFDELLTEGFDNDQIWEELAMQNDPFLSYAKEQLEQFEDMEEEEDSQSGLSLEDIDDDQLEAMEETDEFDDETGLDDEEDLEEELLEEENGEQEMDQDELLENEDDEEEDDALDLEEFDERPTRKGKPSEVDDEFFDLNEFNEWTEKQEQQDMLSEDERELDEEIDFDDDLEDDLEDDEEQNANDIKFSDFFKPPPKPFYSRESKGRKDAAPPKKKKGAFDDMDLDEDEDEDDAGSDLEDNVAETEEDQPKVKDLFADDDKAEGDEAGKSGHERRLERVKQQIEEFEMQNVGKKDWTLGGEASAKARPVNSLLEEDLEFDHAAKPVPVITQETTETLEDMIKKRIVDNNFDDVVRKADPTDRPFLPSKLVELDDSKSKKSLAELYEDDYVKQTTGATTNEKDEKLANEHREIDDMFLNLCSKLDALSNFHYTPKAPKPEITVVSNAAAISMEEVIPVNVSDATLLAPEEVFDKKRTDVKGDTELDQGERAKMRAARKKSKRKEKAMKEREMKVVEKMNPGMGNKHAKSKAVKELVGQKNISFIDKDGKKTSGQALAKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLQ5</accession>
    <name>A0A8H7PLQ5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heparinase II/III-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLQ5"/>
    <dbReference type="OrthoDB" id="2334866at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38045">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38045:SF1">
        <property type="entry name" value="HEPARINASE II_III-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="624" mass="69117" checksum="58F4CF83F8F63779" modified="2022-01-19" version="1">MFKKLKAKLQHQGSSNDYPGSSGQTNDFQVKASTIQEALNQQGPSIPELSADGPSLANTEQCKQLLRITDKFRVQDIPVLNDHLYGEYKRTGDRKSYEDPYFARRAEMTAHALAAYVSSQPEQHINELQKHIDAICNEPCWVVPAHTRCKVDLFNAETGFALAQIVDVLRDKMDGNLVNRVYQEIDKRILTPYEQNGRNEEWFSAVNNWNGVVNSSVGSCFLLMPIDPKRAANGASQALEGLSHYINKGFGSDGATTEGVGYWQYGLSYLTAFLELLSTRTGGKVDLLTHPRLATIASSAAKLQLGPNKFAPFADADEEKMTFTPGFVSRISDRLGQPELKNLLALPQGGSFSQSTVAISKSALVFRDLAWWNGDMPPADTNIGDSVLPDTGITRMSIKSGSSPPLVVIAKAGHNGEEHNHCDVGSFVVHFADANYITDPGKGLYNKQYFDAKTRYQTMWPRSDGHSVPIPANKLQGVGEKFRGSISGVNQEGNGKSIDIDFAGAYEGCPDLSFLKRHISIQDENGRYVVYVQDTGSFTNQQPLRSQFMTFMDVNQENDKSVIINGPHQAMRMTVLEPESATLHIEDLSEESQKQKKPKPLRRIVADVREPSKDYCIKVKLEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLZ2</accession>
    <name>A0A8H7PLZ2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_005727</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLZ2"/>
    <dbReference type="OrthoDB" id="5559380at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051293">
        <property type="term" value="P:establishment of spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013889">
        <property type="entry name" value="Karyogamy_KAR9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271:SF1">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08580">
        <property type="entry name" value="KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAR" evidence="5">
        <location>
            <begin position="879"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="380"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="486"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="828"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="501"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="661"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="694"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="757"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2176487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="994" mass="110540" checksum="146F059F9BF28D1B" modified="2022-01-19" version="1">MDVNSTSQTAGALSDNVTRSGYIPDQALSGTNVHQTGIKELLAISLPESQLAEVISYFQQRDLASTLEVTNDACRSMSHWLNVANLVLYSQEQQTASAVETVDFQSLNAGIKCMQTCVSSLQDIFEKLEERNRSMLDDGSPLEQQEAAIKLTITKLQSEWSAFKHFFSSVTKQISGIQERKRLLEMMNDILMQIDELSTVIFEFQEKRHAAAAAADIGEPNSGLHTAGHTELTQSEKNRDDLTLMHIDSRVEPLFAKVDSVYTQLVSPNPPYDPEGILVKRHLVVQQKWESLRIEIDELKDELKEDRWLSVFRQVANQVDVMIDGLERVVSHCQQVVSMFKEWKSPERVSKQAAGGNNSSSTIGSFERITKNFLKAYPKSHHSSTSASSMNSNSSNSTAASTARNSTPPLDREKFRSLVKGFEAKYKYYTPAIDRMIGMLGTGISQRVTHDTIAKTRHNAIKEKWESLRSIMDDLRSNQLPEIERSIMERPSSPAWSGTSEDSHTTDRSEKAQSHWKGIRLLSSPSPASRKSDENGKGSNASSSSGNMWSMMRSSRASPSPVPNGRPALTHITRGSDGQSSQSSNRGLRKTHTPSTSHNKPTWNASTKTDSKQYSYEPLWKTENRQLGDLDDKEDEELMRRGRTKSPSRFGRRDEEHDDQSSVSWMKPTKSTIMRQRAQSVDRAMSRTTDVRSKTPTSRPKTPNLPSHRSKTPTKSREASVGQFLSPYSSHEPIPYPDRDRAVSPSGRRSETPSLIPRPKTPTSRPTSPLAGGPPRPSSRAKTPSSPSLIPRARSALGHHTPPVPPLPKSIHSEEWLPVQSFGSLLDMTSPPVPRLSKKSSTPALKHGSQYLGARDYLSVANTNEMQINIDEIPHYVPDSKDPLDVEIGKILNASPIAIKCQRSPQGGGRYYFGNDLSPSLGGGKKMYLCRLMNYAEKSNVDPSLLSSRTRSKVSSSRNKVLVRIGGGWQDLEIFLLEHASLMVSDVVVRSFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMG9</accession>
    <name>A0A8H7PMG9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_005634</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMG9"/>
    <dbReference type="OrthoDB" id="19419at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2176400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="162" mass="18731" checksum="F1F7C6167D2660BD" modified="2022-01-19" version="1" fragment="single">ISVLFEDIDQELLNNITDFHIEHDEENPDTYTVSATFSKNNTFENETLTKKITVTEDGDAADVQKSTIKWKSGKGPDSKKRKAGEEDFETTSFIEWFGDDDHILGSLFRDDFFPDAIRYYNGEEEDDDEDDEDLDDIELGSEDEDDEEDDEEEEPKPKKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMN6</accession>
    <name>A0A8H7PMN6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_005730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMN6"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618:SF1">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="596"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="534"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="100"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2176490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="832" mass="95079" checksum="DA4C2C8379E70346" modified="2022-01-19" version="1">MTKPTGREEESYKESDIPPVYNGRNQRPHNTPTKMRHLASSRKDNDLKPPHVSFAFNPQYSISAPSLHSVPQIVVSPSPAAQPNGSQEFAQMNTFASKADNLHCSSPTTPTMPSPVLSEDIDYTPRTSVDDCDRQQKKHTQYYQETDDEDDNNDRMSNVDTLYGSPSVYSDYEDEVPIGNFSCGCCPLWWMQRAAWFRRTVINLCIFTVIFVPGLTARLVLRDDFKIIAIPIDRWFEFFGLVIFGFHISRLVVYITLKCIRYFSTGKLQTKIEMLQFIQFTIALCLWALACFSGWHFIIKGPDCADPNHCDEAKLFPIIGNIIESLVYACFAFCLERIILIQISTVFKKGAYTDRIVQCQFESDMIEAMLKCRHIDKVEKKIAKAQSRRPSQGELFDSASFNGSLRHNFAPMFKSQPEYPSQLIHCSSESQYGASSIATRISVEVEEKLKPSKAGLEIPEGLLDASSSQYGERKHANISVTQMTKYIQKIRTKKLLNVIGSIEDANKYAKKIYLRLCPRNRGYIAIEEFQRVFNSKRTQDFVFQWLDKDMDGKITFGDMRDAVRRIYRERRNLAKSLSDLENAIHKLDVIFKSITTILLLLVTMLVFEVSVVSIVASFSSVFVSMAFILGNSAKNAFDCLVFLFVVHPFDVGDRIILDDRMYIVHKLHILTTVLERGDGLYVYIANHILAQQYVANIRRSGDMIDEIRMDCNRLTTAAQIYALRSSLQEFVTRNTEIADYRSADIIVDGIMDGYRLRINVQMTCRGNFQDSTRKNKRKVRLYLFLQDQIQKLGIDCRPMTIVDATPEPVLDDLDEPGPIYSEAQKIAQAMRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PN29</accession>
    <name>A0A8H7PN29_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alkaline phytoceramidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_007773</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PN29"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF3">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2177117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18558" checksum="9B2883F08B1462C8" modified="2022-01-19" version="1">MVWAAIALFYTMLETRFGPMPKIAVGFALYALGAAVLVAFPDSKYQFYIFHATFGSLEVISIAMIWSIYLLKKDAIPGLEALFKRGISIYALAVACWMIDLHCCSWLSSLPINPQLHAFWHIFASSGLFYLCTIVYVDRLHQEGKSPHVSFNHSWLPVVNYKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNR1</accession>
    <name>A0A8H7PNR1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNR1"/>
    <dbReference type="OrthoDB" id="2434730at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="163" mass="18553" checksum="8439925C70BE2B79" modified="2022-01-19" version="1">MEDNAPYLVVREIEETEFIELYPSGITEGGKRIEDDNYEVSDSASGWSDEDSDTDFDILESHWFPSLGRNSIIEYLDDDDSNDESQQMSDIRSPFADMISSVEAIIEESDDSEDEMEDILEEIGFFSRKRSSPSKRVSQRQSKVQKPNSPTSTVAIEVTYVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNT6</accession>
    <name>A0A8H7PNT6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007746</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNT6"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF17">
        <property type="entry name" value="RHAMNOLIPIDS BIOSYNTHESIS 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2177090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="262" mass="27787" checksum="4DA6F1148269FB60" modified="2022-01-19" version="1">MDIQNLFNVKDKVVLVTGGSRGIGEMIATGFVSAGAIVYISARSQDVCDKVAKELSAKGPGKCYSLPADLQSLDEVKRLVAELSKREKHLDVLVNNAGANWAAPVDEYPEDAFEKVMNLNLKRIFSLTQACLPLLLAKSTAENPSRVINIGSINGINIPGLETYAYSSSKAALHQLTRHLAGKLGDRHILVNAIAPGSFQSKMMKATLEKFGDVIKAGVPVGRIGSPEDIAGTCIYLSSRAGQYTTGAIVVVDGGSLVAAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPK9</accession>
    <name>A0A8H7PPK9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="4 12">2.4.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Asparagine-linked glycosylation protein 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ALG13</name>
        <name evidence="14" type="ORF">INT43_007886</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UDP-N-acetyl-alpha-D-glucosamine = an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23380"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19510"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57269"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.4.1.141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Heterodimer with ALG14 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="4 12"/>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPK9"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039042">
        <property type="entry name" value="Alg13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867:SF6">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLDIPHOSPHODOLICHOL N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="13">
        <location>
            <begin position="4"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2177229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="178" mass="19697" checksum="7BD703F3655009E1" modified="2022-01-19" version="1">MKALVTVGSTGFDDLVASAISSDFLSKLYDIGYQHLTIQYGSSESIYHDRIANLDLTSGRTPVIEGYRYKSDIKQDMVQADLIISHAGDKIDTSSGSILESLRLHKKLIAVVNKRLLDNHQDELANVLEKQGCLIKSTSSGLADALTALKAKEFTSFPEQDASKFNDFLDREMGYMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPV5</accession>
    <name>A0A8H7PPV5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multifunctional tryptophan biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Anthranilate synthase component 2</fullName>
                <shortName evidence="16">AS</shortName>
                <ecNumber evidence="16">4.1.3.27</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">Anthranilate synthase, glutamine amidotransferase component</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Indole-3-glycerol phosphate synthase</fullName>
                <shortName evidence="16">IGPS</shortName>
                <ecNumber evidence="16">4.1.1.48</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
                <shortName evidence="16">PRAI</shortName>
                <ecNumber evidence="16">5.3.1.24</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="20" type="ORF">INT43_003245</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="16"/>
    <dbReference type="EC" id="4.1.1.48" evidence="16"/>
    <dbReference type="EC" id="5.3.1.24" evidence="16"/>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPV5"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000031">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_B">
        <property type="entry name" value="IGPS_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016302">
        <property type="entry name" value="Anthranilate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001377">
        <property type="entry name" value="PRK00278.2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF4">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001382">
        <property type="entry name" value="TrpG-trpC-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="17">
        <location>
            <begin position="4"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="18">
        <location>
            <begin position="229"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="19">
        <location>
            <begin position="572"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR001382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG2177992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="753" mass="81926" checksum="B856532894EE2868" modified="2022-01-19" version="1">MTTVLIDNYDSFTWNVYQYFSSLGAKVVVFRNDKVTLEEIEALNPRNIVISPGPGHPATDAGISRDAITHFAGKIPIFGICLGQQCMFEVFGGKVSYAGEIFHGKTSTISHDGKGIFKNVPQNVNVTRYHSLAGVVETVPEPLEVTARTDHGIIMAVRHKEYAIEGVQFHPESILCEHGKTMIQNFLNLKSGKWNEDAQAGVVAPTAEKPAEKPAVNGVKSSVAKPSVLNKIYQQRALDVEAAKATPGQSPEDLRKLLALHVAPPLIDFVARIKQSPLALMAEVKRASPSKGNIDLTANAAEQALKYAQAGAHTISVLTEPKWFKGSLMDMRLVREALASVPNRPAILRKDFVLDTYQILEARLYGADTVLLIVAMLNDSLLQELYNFSKSLGMEPLVEVNNDEEMSRALALGAKVIGVNNRNLHNFDVDMTTTSRLAEMVPEDTVLAALSGITSRKDVETYIEQGVKAVLVGESLMRAEDPHKFVAEILGHEEPLPKQPTETEKSTLVKICGVKTVEAALAAAEAGADFIGMIFAKSKRQVSIEDAKKIITAVREKYSSVQEVQNDNEPLPRDWFTAHARLIEKTAKKPLFVGVFLNQPIGYMSQVASTLNLDLIQLHGTESPDISRYLPVPTIKAFHIDSESFSPMQIPTISQPGYNALALLDAKVPHLGAESQGGQGVTFDWSIARQVVEQGHASNNLPILLAGGLTPENVTEAVVAVRPWAVDVSSGVETDGTKDLEKIKAFVANAKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQE0</accession>
    <name>A0A8H7PQE0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003419</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061499">
        <property type="term" value="C:outer plaque of mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031028">
        <property type="term" value="P:septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052574">
        <property type="entry name" value="CDIRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566:SF1">
        <property type="entry name" value="PROTEIN NUD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="16"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="506"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="564"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="861"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="511"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="863"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="881"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2178166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1562" mass="176306" checksum="62321424C71A0C88" modified="2022-01-19" version="1" fragment="single">APLTTYLRPISRISGKMQNGDNILSSDKNQSESVTGEQEDLQQNQQTQQKPQRTPAFANQLPPSVSQQRVKPKRSTNALHLLFLEAGKLANLYIKYILRSLCQKNENEIISLAKDRKKLWAEFKSFANAQILEEAKEAIFPELTEKGREALSDVSPENEIIEMRFDEHEAIERSFEDAMAELRYDHYEDLGSRQSKSESDTADDEKSEAIVKGDNYPEALPTIFRIWDQHSYRRSGRDNSESRSDWSYEGNGVGGKYRMNRSTAGRPGYPPRHAPYYPPPGPRSRDGYRRGPSPNRDYRDRPERDDYYRERRYDDRRPPLSPPGSEFRRWSRDDRGPPPPAARYDSRDRDGYGRPSDDRYPSRVPARGPSPTREPRVTMGPVHPNLSGRPSKSTYEAAPVPITQQKTPEVPVESNYGYGNGYQNASAAYNSGYYGQYQNQNVGSMYGSQQAVYPAYQGQGASAQQQQWPQQFMPPLPMNSFASRDYEMSGTAIRSQAPFNGQRKSIHVLSGHNSPPDKNNVRRTTGQRLKKDTAVRSTLRSTTKVRPEKTRNAIPAVVDTLQVRMPAPQDTNTPTSSLSSSANEISSPEGSEDLSNFSLNGSLGKKMADILLEQGALSSDQDIAGSTDELVSPVWLPSKESSTIHIKDDADNSRAPLVDNGACDPTNKGYNNGVHQFLADRENDDWTPTSLQAGKSSGLDFDVKKAKNDGDAVSLEQQQVRELVEKLKKAISSHSICEKDSATNLDSNLSPDYFKLGSSHQLSSSIWSETNPIPSDISEEGSLANSYEIPSLPELDRPTLPSRQSSDADINAIWVKDQENAPIAWLSRHTKEMSNQVQSAGYACPVPTEFLPKAEIVEASAEVETTTQSEVSDASQWDENIPPSDIPSSASANYDDDRYSSQLVKHGQVDVNGHDVDKDVTATFSPVDGDDCKNSSVDHSIMSDSSALLQEENAAATYEKSSIIDSNTESSPENIVQTQTRPPRRIMHRHTYSFSRDVSLAANNVIDNAAHSEEVIQSQSVSVSFNKQYTPIEKDPIARAFHRIVTTQNAEDRDDESQNGKITTREELLEGALISQEASRDTSLTTIVDHLARLKPFQEWCQIRYLDLSHQNLSMVSGLRDCVPALEILNISHNAITHIERLPTKLQQLKAHHNRLTNCSGFSALQELSYINVSDNLLESLGELKTLRCLREMHAENNIISTWDGIRQLKMLTKLNLSCNRLRTMDFSKSSLSSLEFLNLAFNRIERLEGLKLLHMIKKDELVNFFSLDHNEIKWINIYQPTRRLELLRLSFNRLRVLDASSFPSVKTLYLDDNQLMSVKNLSAMASLESFSMRDQGGHKVNFEVKDLKRVRKLFLSGNPLPNLSEFHHFEHLEYLELCSVQLQTLPTDFSFQFPHLIVLYLGGNYLTDITPLSGCSSLQKLVLIDNRLDDVHSLTKTLKQLPSLYFLDLRLNTLTSKYYATLSNPTGPSKDLITHYLSYEHDMKWSENDLIFNRCMPDLWRGKRDEYRASILKACRKIKSLDGIKFDKDEYIQAKKLLKTQSKPELRRKTKRIPAVPYNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PR17</accession>
    <name>A0A8H7PR17_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF2428 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_003196</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the THADA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="73997at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056843">
        <property type="entry name" value="THADA-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056842">
        <property type="entry name" value="THADA-like_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019442">
        <property type="entry name" value="THADA/TRM732_DUF2428"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF0">
        <property type="entry name" value="DUF2428 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10350">
        <property type="entry name" value="DUF2428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25150">
        <property type="entry name" value="TPR_Trm732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25151">
        <property type="entry name" value="TPR_Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like TPR repeats region" evidence="4">
        <location>
            <begin position="570"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2428" evidence="3">
        <location>
            <begin position="1016"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like C-terminal TPR repeats region" evidence="5">
        <location>
            <begin position="1273"/>
            <end position="1430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2177949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2013" mass="227914" checksum="DC14BEFFCFF0A17E" modified="2022-01-19" version="1">MGTSRQKMPQKEPIPIPDRWQRLVVSCDLHPGLHVLQDLLNGRDLKWDQQMALLRKLEKEITKQEASDDRQLHHQIEKTLLPVVNEAYFVAPEALSRRYLISLIELAQHMGVERNLFSITYLQFMENKEPFTNLSVTHRATLIATMLEHKMGIQAIEKNFNATIFYLLSHLKTLQNFHPNFNAKISSVTDNSIEWPFGRSVDVLLADAQHILKSLLAVLSKGNYEQNQVLRENFQQDKELQKDLLQTILAMFSLQEQYNIDCLQVAGMVIVATVNAVVDVDSSLRLLIGWFFETPETTSDLAIRYANCLGLTFPENLVGDAGWTTSDSPMLMIVRGMVSNMSMSASLHHVDIKAPRQRLLRVDPEANFLQLCFQALCIFCSNSKLEPQCKVIAFDAMAIWLQRIKTLLKEGIGSEDIRVLDKVLTGEVRERLVTYAWSHWDDPVKAIFELLLEVLKLQSEILCKEEQYQIFVRNLLCQLLAMDWHRKVKYALLSLLLPSLSTSTFLELQPDFIWRCLSVMDNMSILPRVSALLCQFLEKRLLETVPQYRKNKTQKGGKVESEGGVEVQDWVDLWLTPVLRALSSSSDILRRNTSHTILMPMLQFYPSCVWRIMSILQDENVFMQYTGKESQQYQLNAFISVIKVARKLDIIEADSYSEDHKSSANTISLPLLRAAMDHIDVQVRIDVLGLICESKKSGSYITETELRLLEDFLPLNLNSTSPEFRQNMYSELTKFFTKLRGNLFSQYRKQLSTQKYAENEGVPAQKKQLALEEANVLRSQILLSKEFLNRLIDLMFTSLHPGTSFQRAFTVLRILSAFVGIFGVTEVPTPEGFVGNPIFPFDIDLATKRHTKILVNMLMDSYDQNRNLSFNLLMQFPSPLPGYEEPVTVQRLLWWGLEKVRSKRAGESDSGAMVFRLVFRSYIATANFDLEVEEHTTENSLSNSGNEDMPIILRFAWKLTDLIEKQLKVAKDNILLAAQEHPMHGSLLALRYLFQELDYSTLVDDTNRSLWQAINERIVDLACEISDVVLDVLSNPSPEGNMPASFQEIEEALDDIIEENQDEDNESGSPKHQVILSSCWRAIKEASTLLEAMITHIPLPKYSEEPLISENHLLRCGNLLRTLLMCIRHRGAFSAVYPAYISLCSRLLMSSNSELAKMPFNWLEENIQSITSSSISVTRRSAGLPLCIMAIISSETSGRKSMLQMTMKKLIEIASATVSADANQTVDAPQVHAYNIMRVILMDSKLGNDAIVFAEEVFHLAIAGFSSLSWAIRNCSVMLFSTILQRTLGVKKTRDEHSTLNLLTATEFFTRFPQLRPYLVEQLTEAVEQLIGTETSRVHPGLYPILTLLSRLQPSSVDSQAQKESLSAIVPLVTSCSPSTIYKTREMAARALVPLIPSETVIAVVSQILKSSNLSDQNKLHGKLLQCQYLLRGHLYKKDSYSLWCTAVKELSKVLLSSFQLLLVHNDCPITKSLLLDIILEFFIVCDIPSIEDNSVLEEFQALCSDNLTLFRTHIANYCKYDLLTLPIDIARESPVAGSYLLRQKQAEMLATSYLKCVPLEITLPKDLIVQLLGISIYEVRLSTIQLASKMLKESAQGLSDDRDLQRKLCAMIYEEESHLECFRNAVLLLTHINPSKPYLDDGTMAFTIDEFWTRVVKQMQSSRNQSSQEAILPLMGSLLAQVRNLSSYALGMLSEILKAHNGSITSSQFFRTWTATFCKYSDANVTLPLREAATSSFAFMASYIFSNVQEIRKGKLVDEIVSTHIAITQLLQDDDLDVRLEMAAIVSSATGSKMDVQPEKALEIVYHHLKQNYNDCEGLQAAIENMLTNIISIDVMGIDEEVSKVLFEQESPNIYREPLIDSQWCALLLANIDKRGVNHQAALKSLSDYKVIAEAFKRDQIISYGPFGLLQRKDIFLAIYNVIILANATLHQLIAMDRSDLFVHPLQELQSALSEMPTDSLPPALTYVIEGPGGTFSLIKALLQEGENLVELRNADTLPLANPYFLIKCHNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRL5</accession>
    <name>A0A8H7PRL5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_001856</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRL5"/>
    <dbReference type="OrthoDB" id="421009at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021538">
        <property type="entry name" value="Syntaxin-5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11416">
        <property type="entry name" value="Syntaxin-5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="250"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="170"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2179007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="348" mass="39941" checksum="0A7EACF17D00E910" modified="2022-01-19" version="1" fragment="single">KLQGMTIRNRTEEFQAVASRLSSRTNPNDRRAQINLVQHVPKRGNVSAFTVTARELARHMRITEQELGNAYIRSCTQTNADCSPNFAVTNRRTLFDEKPVEISELTYVIKQNISRLNHGIAALQSTTKQGARFPHQVVEHHNEVISGLQSRLANASVAFKEVLEQRTENLKASKERRDQFFQSNEERSASPAPPAPANHSYTPPEPTELHRRKNYTPQVPMEEEETTLSLGIPMLTPQQQQLQQQQYAESRYTETRSNALESVENTIQELGGLFQQLVTMVAEQRETVQRQAWNSYRIGQNTEDIESHINVAQSELLRYYRNISSNRSLMLKIFATIIFFFFVFTIMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PS52</accession>
    <name>A0A8H7PS52_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PS52"/>
    <dbReference type="OrthoDB" id="2398458at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF117">
        <property type="entry name" value="LP05237P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="297" mass="34282" checksum="58C6734B3BE64A61" modified="2022-01-19" version="1">MIPNTLYRLIRTGVVHPYAAYQTYKVYVSRDPMGAEHWNMYWMVIAAYMALELVTDIFLSWLPFYSMAKLLILIWLTALKTQGSTVIFHEIIHPHLAANETEIDEALATIQSHAKTRVLLVSKRAYRGLESLLAVGVAQSHILLDMYMKQRLFVGSKNQHMIDSSTGVTKYTRRPIQELQEPFAQSQMKKFEASEHRRFLTPDHNLSVPNQGLPVRTPSPSSYTREHTNLRGPRYREYSREQQERYNTNRREVSKQQWHITCTTTFAISSTGTILKTFVPTCLYLSSIITVADIVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PS85</accession>
    <name>A0A8H7PS85_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NELF-A N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PS85"/>
    <dbReference type="OrthoDB" id="2135488at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056557">
        <property type="entry name" value="NELF-A_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23553">
        <property type="entry name" value="NELF-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NELF-A N-terminal" evidence="2">
        <location>
            <begin position="95"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2179141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="604" mass="67069" checksum="370A35753DEB87E2" modified="2022-01-19" version="1">MAGRVAQELNDDILEVVQTQYSTYHANIRIGILFALLCIRKGQQQSLLENINRSRRQLRVVFSHVLANANFEFMQHIGQFGCNPYAESILISTQTLERASKDTEEWVVVTAHALKGFPTRGGLNFDLEATTDKFADALNHIGSAMSKHGISFHPKEFAYMDKKRLPACSSASKDFKKLVPSVKQHFKLSKNSPSTISREDRLSQLRAIAKEASFSPQQSATSIVTPPTAAGSAAGSENIAAKPGAGRGQPGSSLFIQRPGNRVPLRKPSTGSKPSFLRAGNASRPTPVSTQPRGEYMLTFLDVKVNQRLINRSKLPTASIQSILSGGANASSSAEDLSTPKGFIKPSKIQMIDINESAAIQENIDKANAEVQAQNELKKQQAKQAAEEKKRAAEERKQEMLKEREEKKERRKQEAEDKKRKKEQERQELAMQAAAAKEEAKSAAQEAQGDSPPRAKRVRRSSDAFGEDMTQEQRSSDAGNPSYENMPVPSSIHPPIPSMQTMQSILPPSQPPIMPLPSNSPSHQTHHAFYYSPPGPHSSQLPAPEHMLHNAQPNLPPLYGYSQPPMSFTDPNHEQYHQPYQQNRQYHESDPRGHDYYSNQRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PT12</accession>
    <name>A0A8H7PT12_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_001848</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PT12"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2178999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="468" mass="51444" checksum="5D58D665FD38B4DA" modified="2022-01-19" version="1">MTPPKEASEFIDFVNASPSPFHATHEATKLLRKAGFTEIKERDSWNDGKIERGGKYYFTRNGSSVVAFAVGEKYKSGNGISIIGAHTDSPCLKVKPVSKKEKAGYLEVGVQLYGGGIWHTWFDRDLSVAGRVLIAHEDGTFKHTLVKVDRPILRVPTLAIHLDRTANEAFKFNTEVQLTPILATVTKSTLNGTDKPSDENAESEKNHHPLLIKVLAGELKVKPAQIRDFELALYDTQLATIGGAFNEFVYSPRLDNLEMSFCSIKSLINTADQLADEPNIRLVALFDNEEIGSTTAHGANSNLLPTTLRRLAATQIGDDKVSPTAFEESLHKSYLISADMAHAVHPNYADKHEDNHKVEMHKGTVIKINANQRYATTAVTTVILKELAKAHNIPVQEFVVRNDSSCGSTIGPMLSAKLGLRTVDVGNPQLSMHSIREVGGTEDIPNAIKLFDAFFLEFAELDAKITVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PT24</accession>
    <name>A0A8H7PT24_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PT24"/>
    <dbReference type="OrthoDB" id="2228at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="579"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="680"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="595"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="710"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="737"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2179802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="749" mass="84168" checksum="9BA1584577D2F659" modified="2022-01-19" version="1">MAPPLDQPNGQEAPHYFATTNQSGLEVPGLKIYHTNMLVLRVITFNLYDLFYVLTPFTFLLWCKTEFSNDAFEIVGLMDSIRAVQPPEKWKLMVIDSQSIKILTAVCNKFDILEENVTLNDDLFSEFNRRLKARNASDYILGLKEMYVDFMAVEPSVFTFDRPISFFRLFSPEERTKFEPELDKLAKHIMSICATLGEDPIIRYHRPLDDETGAPVNKSLPYKLAMLAQREIDNYCRVNPNFPPRRTPPQPRATLLIVDRSIDNIAPLLHEFTYQAMITDLLPVEPAGAALKYKYDYSQSDGTTGSKEVILEETDNVYTTVRHLHIAETTDKLIENFNEFLHENKAALGASEHTGPPKDSARSLRDMKDMLANLPQFQDLKAKVSSGRSHVFASNYAGTNDALQYSAHLSIAQECMSVFEKQKLNSLGNLEQNMATGETPNGSVPKTVVLDMVPLLDDPYVTPLDKARLLMLYIISKEGGIFEEDRKKLLEHARLPRDLREAINNLSILGVKVTRVRRQTGEKSLRKKLTRRKSDKTEEQPYELSRYVNNVKRAMEANVTGTMDAAQFPFTRQSDAEMQEDTSKPGANVPATGVSLRSTKPTWSNKKNSVGVSDKRGTSRTPTGAKLIIFVAGGMTYSEMRSAYEIADIHNREVIIGSSHIITPAGYVQDLSLLRKPAPIPTRIIPPYTPPVTPQESSRSLRPHLPHLARSQSPSPLPSIATTKSSESAIDSEKSEKQKKKKGLGRLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTD7</accession>
    <name>A0A8H7PTD7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Utp21-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_003998</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTD7"/>
    <dbReference type="OrthoDB" id="10250769at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000200">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000109">
        <property type="entry name" value="WD repeat domain 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059157">
        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25171">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25168">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04192">
        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="5">
        <location>
            <begin position="52"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="280"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="480"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="563"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="4">
        <location>
            <begin position="690"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2180209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="898" mass="100669" checksum="6F45C8D873D935AD" modified="2022-01-19" version="1">MVSETIKKRRLEQESKRSAAQPRIFHPFRAVGYVTNDVPATFEARGQDFFMTTCVGKNFQIYNLKQMNLLFVGPQAAAPLTALATLNDITFAACGNQVIIYKRAKEIARIVGEAEFAIVQLVVFGSHILGLCDDNILRMWDYKTQELYTQVEFDETFTASAILHPSTYLNKVLVSSNQGTMQIWNMRTNQMIYSFKSFGSPITSLTQSPVVDVVAIGLLDGTTILHNIKMDEKIDNVRQDERVTAVSFRTDGQHIMATANMQGDIALWDLEKRSLVHVMKGAHDGNITSIQFLNSQPILVTCGSDNAVKQWIFDNLDGTPRLLKSRSGHHSPPSKIRYYGHDGHFILSSGRDRSLRAFSTVRDAQTVELSQGSLAKKAKNYNLKIDELKLPQITQFAASERKQKEWDNILTCHLNDNGARTWSYKNKVLGKHVMQTKDTSAVKAVAISSCGNFGFVGSGNGAIDMFNMQSGIYRKTFHGESGHKKAITGIVGDNLNRYLITSSVDKTVKLWDFNSAKLLHTITLESPIVSIEFQRDSDLLAVACDDLGIRVVDIETQKVVREFWGHRNRITDMTFSSDGRWIVSASLDATVRTWDLPTGNLVDIFKVDDVATSVTFSPTGDFLATTHVDNVGIFLWANKTQFGSVSLRSITDDEVAELISLPTSSGLEEGVEISNDAGEQDDDQVDGKTEQLTEDMITLSLLPRSKWQNLLNLETIKLRNKSKEAPKTPEKAPFFLPTLPGVVSKFAALEKTNEAEDEDKRFRGGFSSDYQSETEFTRLLRAGHEEGGNYTAFISYLKTLNPSGIDFEIRSMSLDSELTLLNYYLEAMEYQLKTRRDFELVQAWLSAFLNVHGDIIVANPGSITDRLQHILQSHQQEFTRLSEQIHYGLCLIDFLRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTH0</accession>
    <name>A0A8H7PTH0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTH0"/>
    <dbReference type="OrthoDB" id="2593073at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF9">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="42"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2180042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="469" mass="53108" checksum="521F9D1023653AB3" modified="2022-01-19" version="1">MSNWNFQHFDTQSEIGIVDENGVTHRVRKKPGRKANPAASAQRKAQNRAAQRAFRERKQREKKENDATMRRTNNEIAQLRRTVKELSYENKQLKGILLSYILTCFEMNTPHPRVNGVHMYGGQHKSQDEDTPTLLNVFMDESKRVVNMETAALNLIDADSPYPHCTAPSRNLNNERKLRRMFDEALILDELPNQQLLSDNQTATDAIPGCNHDLFSSAASTSSPDTNITYSSPNGDGMASQSVQSESEVSQPMQLEEELKFPPPYISTNDNTPVPGIQRFCQNLHMPTGASENLYLLASNRQVVQDVWNNVVGSDDKFINAPPPPSWGSEDPATFANWDTSEYSYPPMHPLQAVQLLRLQMKVGNILGNDKDILNPTDLQAAVVHDRRIDYIPGPGMRDRMILFRDHYDADDCFNMLATKSIFLGGDVTNPSNWALPEKFYEKYWFLCANQVGVCTVETTLKCLLNYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTY1</accession>
    <name>A0A8H7PTY1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTY1"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="598"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="925"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1044"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="617"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="942"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1044"/>
            <end position="1103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2180153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1191" mass="133381" checksum="42A4E3FB055872EA" modified="2022-01-19" version="1">MAFLLKRGLPIQTTKSTASMYIMPHQKDALRRSCVYDEKANQTRRQSSQPAVQQLPASVASVSSESERRLSTSSDKQSDFACQCDYYKLKIRDLEAHIQSLETKLEWESQLPKHEGLQTDRNKQTQSAGQEKSANPRKRAEATDIRQNGAEPSAKNQSSCNISFANDLYAYIRSHPPSVRANQARAYISDTRLPPLLFDFYNLSSQPHTIWIAFVNCMRTWSRQRHQAPAANKIEHTNKLPLTDNLSCEMLKLHTSHNYLYSSFIDTSKATSGKQPSTNWLSKLSDKPFFKTQTAASGCDETMLVYAIFANVLLSASQSLSISSPDIAEISRQGSEGYYHQAHRIFTSNVFPASHPAHPAEPTMEQLAILTKTSVLLTHYQCATISEEHAFLTFKIGLTFAERLGLHKLSSSSMHNIAIDQVKFADDDSKRLWISSDKVNDEECERLENLWKVMRGWDIWFAVYLDRPPMVESTDAQSSQPLASLKRMDPRDWAVRVVEAYTDNMRSMSQSLITSSCSQLKSMLDNLKAWSSSFITKQGKSGDKSATESAIHLSASILSLYHDILTIQLFRSRALPALKVFGDAAGWVPSKHKSPISLKRRLDTEPESPTPVANNDSGKHDPKKDKPTSKKADVMQQNGKLESSDHSEVKMATACCTMAARSIVETATRIITTHRHCAGAPLVLYPLCLAGTVLLWQYHQRSRMGSSAKLHRKEIVDQESSEILISDDFDFNQVLISFKALTKDISTSFPVAEPVLLVLDEMLGSNNVAGHSPDPSSIGDTPMNDLNYVVSQASQNNHQQQIRQMNMMLQPDWMPEFQPDGMIDMNHSLMQDPMFPSQRHPTGPFPPPNYTHMDMLNLSRGEMDREALGKLDRDYRDNATATNAYTNQSAHMLVLSSQLPMNFAMGQPMYEEQMANFGNKKTTATAREAAEFTSSKSNPGRSAATSKSSAALTRQMWLQQQRQQQENGQFPFEAYSNQMMAHKNASKKSRVDGSYEEISDTNGDNMMKHEFATFAEMAAAEPQVDFVYPSDLNSFLISDQTINHQNNHAAPSDPMSLQHQPQNNVAYSQRAQQQLSHQRSVSQDTPPTTHPYISNTAMASTPHTKLPLPAPKQTYTIQKSWPTTTSSREYVARFNVVETLHPAHPINTSDVPYIGANLVDPNTMSVVPPQSSPGQQQGLTDQHQEVVMQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTY9</accession>
    <name>A0A8H7PTY9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_004086</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTY9"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.40">
        <property type="entry name" value="Nuclear abundant poly(A) RNA-bind protein 2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043094">
        <property type="entry name" value="Nab2/ZC3H14_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="79"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2180297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="420" mass="48312" checksum="B078AB2191023964" modified="2022-01-19" version="1">MDQTKFIDFQNDIHSKCVDYGYCSEADNRLSEYIITMLLNGKSQADVDSELVQLIGADYLSSFSAWVFEELERRSTSEREEFDVEEVVMDEDDSNKQQNKPLQTRMFLQALRRAKADQDVKQNGSRRTSRRSTSPQRRSSTYDRSRSRSPIRENTSRRHKDREDRDREDRERGSVFSRLGRNGNGRQSDRSISIVRAGKFSKYIKPHEAYLTVALYVSAKQSVFDRLGSQPVLEEEKRNKKERVRCTFWPKCTKGEDCPFWHPRTLCREFPNCPRKANECLYIHPEAPKPVETKAKCKFWPNCTNPQCPYAHPLGAPAPIVKRNPTPCRDGDDCSRPGCYFTHPRDGPVGTAAPCRFGPMCQKYPNCPFQHPLPPGQHRNKQLVLNKPHVSDRGFSVAEDEILERIPVGESADTNMAQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PV49</accession>
    <name>A0A8H7PV49_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="14">3.5.4.12</ecNumber>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Deoxycytidylate deaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Minichromosome maintenance protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">INT43_003851</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="14"/>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="844at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17753">
        <property type="entry name" value="MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000035">
        <property type="entry name" value="dCMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000138">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059098">
        <property type="entry name" value="WHD_MCM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12619">
        <property type="entry name" value="MCM2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23669">
        <property type="entry name" value="WHD_MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="21">
        <location>
            <begin position="198"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="20">
        <location>
            <begin position="1091"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="541"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="604"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="642"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAG2180064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1526" mass="170125" checksum="E0A987AB337EF1F5" modified="2022-01-19" version="1">MFIGITGPLCSGKHTVAKYLVDKHNFTYLSLNDTDDLTEFGEGCMRFNTLKQMQIYVTERWLENFVTCDVDGNGLWLLKKRPFFLLVSVEAPISVRFQRHVQRCQNQRTDVLSLQDFVIQNDLALFNIPEDDSTQLLTDPTSPSRPRKQLSTAQLHTPLYTLMSLSDVTIANAYSSLSQFHACLDDLELTNDERLRPSWDTYFMHLSDLAARRSNCMKRRVGCILVRDSRVIATGYNGTPKGLTNCNAGGCQRCNEATPCGTGLDRCLCMHAEENALLEAGRERVGSGQGVILYCNTCPCLGCTIKIVQTGVKEVVFSKSYGMDDFIAKVFAEAGVKLRQHSPPSMRLEMQVDVTEVDSAIIGKMGWMSSDPMRRRGSQEPKSDYTILGRVISVAAAPNATAAGPLNTGSTAPTNASVATVQVLCNYIGNPPVANASTITIESFGTYTSDCMSYVGSAGWTGFFFLNHTVINTKLGLQPNDTSNSTADNSYQLGNHCQSPVVMSPSVIGTLWHTINDTSAVLGTGCLAANGFPLQSGGVGGPSGAGATMSAATGSTSPSGSSSAAASSSSVASAASKTGWSNAHFIVTFSGLVGAAWADRKRRRDSTNLHSDDAPASSPAPSSLPPSSPAPFFSDLGYRDEDEEVSNEIPDDVDEEEDDDGIDLFGSDMEKWVLTGLYLLYLVSVTKPAPSPSDYREDSMRDRYDLANIDDEDYDHMEAADRAAVEARLNRRDAEIMRREGRMADAFMDGIDDDAENPLPTRRRHRRLYEADMGMNMDDENMAVPEMSLDDLRNMKHASLSDWIVQEAPRRTIKREFKDFLLTYVDEHGTSVYGERIKDMGESNRESLEVSYEHLSQSKTILAYFLANTPLNMLKIFDQVALEVTLIQFPEYERIHRDIHIRITDLPTVNTLRELRQIQLNCLVRVSGVVTRRTGVFPQLKWVKYNCGRCDQLLGPYYQDIHNEIKLNVCPHCGGKGPFNLNAQQTVYRNYQKLTLQESPGTVPPGRLPRRRDIICLWDLIDQCKPGEEIEVTGIYRNNFDASLSTKNGFPVFATIIEANYISKKEDLFASFRLTEDDQRQIMALSKDKHVGKRIMKSIAPSIYGHEDIKRAIALSLFGGVPKNVQGKHSIRGDINVLMLGDPGTAKSQFLKYVEKTAHRSVFTTGQGASAVGLTASVHKDPITREWTLEGGALVLADRGVCMIDEFDKMNDSDRTSIHEAMEQQSISISKAGIVTTLQARCSIIAAANPIRGRYNAAIPFSQNVELTEPILSRFDILCVVKDTVDPDRDHMLATNVIASHMRSHPAFDAGKDNVASIEEDTDDCLSSDPFIPQIIPQDLLRKYIMYARDKVQPKLQQVDEDKLARLYSEMRRESLASGSIPITVRHLESMIRMSEAHAKMHLREYVRSDDVDVAIQATLDSFISAQKYSVMKTLRKRFARYINSSRDNDELLLHMLENVAMEKRKMYQYKYRMLPKEIQIDVEDLDSRARDLNIHDIQPFFKSHLLAKYHYKVDMSRGVIVKAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVY7</accession>
    <name>A0A8H7PVY7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_008643</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVY7"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF45">
        <property type="entry name" value="PROTEIN CLARET SEGREGATIONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="152"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="238"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2181061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="520" mass="57913" checksum="7961ED0AB8DCD7CE" modified="2022-01-19" version="1" fragment="single">TYVFLLILTKGIKMTERKHNEELENLRSRHKRELNDLDSSNQSLQRQKRSLEQELEDTMNRLSDQKTENSKLRATISENSAAVLTMESNTRNLKLKLENTEATLKERERSIEQLTAELDAARITVSEIEDKLLEEEKNRRFLHNTIQELKGNIRVFCQSEAASSVGVANISYPGKEKNQIELTDSSTTSSGTTATKAYPFTFDRVFQPQATQNECFEEISQLVQSALDGYNVCIFAYGQTGSGKTYTMEGSRGASEEESGMIPRTVRQIYRSAEKLGEKNWTYEMEGQFLQIYNETIHDLLGTPSDFGKMKHEIKHEKNGNTTVTDLTTVVLDSPSKVANLLKKASQNRAVGATNINERSSRSHSVFTLRLKGRNTVTGEVSTGVLNLIDLAGSERLSASGSTGDRLKETQAINKSLSSLGDVIYALATSKEGSHIPYRNSKLTYLLQNSLGKHTSMFDMPVLPANRSLIITNHAGGNSKTLMFVNISPLVAHFGETLCSLRFATKVNSCQIGTAKKNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVZ8</accession>
    <name>A0A8H7PVZ8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA polymerase eta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_008905</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVZ8"/>
    <dbReference type="OrthoDB" id="5723at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009314">
        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000008">
        <property type="entry name" value="DNA polymerase eta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000014">
        <property type="entry name" value="Polymerase (DNA directed), eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052230">
        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041298">
        <property type="entry name" value="UBZ3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21704">
        <property type="entry name" value="POLH-Rev1_HhH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18439">
        <property type="entry name" value="zf_UBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036603">
        <property type="entry name" value="DPol_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51907">
        <property type="entry name" value="ZF_UBZ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="11">
        <location>
            <begin position="19"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ3-type" evidence="12">
        <location>
            <begin position="505"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="534"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2181322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="592" mass="66929" checksum="3A5FB10DEB845947" modified="2022-01-19" version="1" fragment="single">QRLTLLPRIEQVRLGLSADQPVAVQQWQGLIAVNYPAKAAGITRHMPIEEAFKKCPNLRPVHVATFNMHDPVARYHEDADQTTHKVSLDIYRKASRNIFNIFLKHCSKVQKAGLDEAFLDVTDIVNARLTERYADEIASGEGISHEIDWEPLGFLALSDEESELVNPTSQPQNGEFNQHLIATDKSPPAPKLRGNWKDLQLSIGAEVAKEIRREIFEILHYTCSAGIAHNKTVAKLCSALNKPNKQTTMRESVVPVFMKSIPFTKIRNLGGKFGNEIESALNIQTAGDLWKYSVEELQVKFGQSQGIWLYDICRGVDTSEDADKMSKVTQVKIAKSMMASKVFSPPLRSLIDAERWIAVLGAEIYMRIMDDFEERSRWPRTLMVHFRAAGEFPGRSKSCPMVRRIDVISPDVLTQRAIELFKACERPFPLLHLSITASGFEIDESTSTHNIKKFFGNASDVKLSTVSMETKSSVESFRPDPKSKNQLKGIAAMFVSKPKASPPENKDGHTQCEECQEWIITEEMQEHADFHFAKRLQDEDRLTDTPTRPPPPPSSKAQSKPSPTSKTKKRKSPTQNDEHKDPRRLFFQPRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PW46</accession>
    <name>A0A8H7PW46_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhamnogalacturonase A/B/Epimerase-like pectate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PW46"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000049">
        <property type="entry name" value="Putative exo-beta-1,3-glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034963134" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="48"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="390"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2181397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="747" mass="78255" checksum="9B1659A11F12EF27" modified="2022-01-19" version="1">MRPLFFLFSSLALSGLTISAPTQNFWYETITHNGISPFISGGNSWTVFRNVKDYGAKGDGVTDDSAAIQAAINAGGKGSGGNGFGTTGAPAVVYFPSGTYAMKSSIQSYVDTVIMGNPINRPTLKALSSFSDSTIIYGKDPGFDATINFYQGIKNLIIDSTAVSNNTAITLLDWSVSQATQLTNVLFNMPDYSLHTGVSTPEGGSGTYMGDLAFVGGKYGINLNNQQYSFKNISFTGCNTGVYITHAFSLVMQGMNFVNCGTGVDGTNGGTGNVGSIVLLDSSASSVGTVINTKSESGADDSIVIENLSSSNSGPTVKAGGSSILSGSVTNRWVYGNTYSAINSPKHSAGVTYTYARPSALLSGKNYFTMPPPTYQDQTNVVNIKSVSGLTVHGDGVTDDTANINTILANNAGKAVVFFPAGTYLVSNTIHVPVGTRIIGEVWSAISATGNNFKSASAPRPMVQVGNPGDVGIAQISDMLFTVADVLPGCILVEVNMAGSSPGAVGFWNSHFRVGGAAGSKAETSCTDPTNPCKAAFMLIHLTATSSAYIEDMWGWTADHDLDANNGMHISTGRGILVQATKATWLVGTAFEHNTLYQYSFSKAQNVFVGMQQSETPYWQGIGSSQLAPAPWTANTTYDDPSFSNCAATDANCRMAWFLNIDGGSNMEVYGSSFWTFFNYDGNCVGSGGSCQSNAVHIVGTPTSTRFWNLNTKSQINMVIDGGAVGATQSANSGSWGGVIAGYLPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWR9</accession>
    <name>A0A8H7PWR9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit I</fullName>
            <shortName evidence="7">eIF3i</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 39 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF-3 39 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TIF34</name>
        <name evidence="9" type="ORF">INT43_008898</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWR9"/>
    <dbReference type="OrthoDB" id="24966at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000127">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03008">
        <property type="entry name" value="eIF3i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027525">
        <property type="entry name" value="eIF3i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24805">
        <property type="entry name" value="EIF3I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="283"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2181315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="327" mass="36752" checksum="564D39EEF266AAD6" modified="2022-01-19" version="1">MRPILLQGHTRSLTQIKYNREGDLLFSVSKDKVVNVWYSHNGERLGTYNGHVGAVWTVDVNSTSTMAVTGSADNTARLWNVQTGKCLKTWEFKTAVKRVEFSEDDDKILCVTEERMGYPGTVTVMSVNPDINGQQSDEPVVTMINDGPKFVVAGWTYLNKFIICGHVDGSITQWDWKKNEKLNTVKPHSESLTDIQFSTDRTYFITSSKDKSAKIFDTITLDELKKYETDTPLNSAAITPKFQEFVIVGGGQDAMNVTTTSARSGKFESRFWHKILEEEVGRVRGHFGPINTIAVHPDGKAFSSGGEDGYVRVHQFDPDYFKFKGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PX04</accession>
    <name>A0A8H7PX04_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">T-cell immunomodulatory protein TIP C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_007116</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PX04"/>
    <dbReference type="OrthoDB" id="10022113at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057089">
        <property type="entry name" value="C2_TIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024881">
        <property type="entry name" value="Tip"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412:SF0">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23122">
        <property type="entry name" value="C2_ITFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034386386" description="T-cell immunomodulatory protein TIP C2 domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="614"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="T-cell immunomodulatory protein TIP C2" evidence="10">
        <location>
            <begin position="502"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2182189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="660" mass="73743" checksum="6178DE2164C36DF7" modified="2022-01-19" version="1">MLGAIALYSQLFSLGGVANAFQYPEAFPKSKLYQLSPQIMGLEDMAGTIAAFGDFNGDKYTDLFVLSTDQSTITIYTWKQNNFTFVPLPNPPHIAGLDFVIENVVPGDFTYDGQLDVLVMGRSNPNNAGDEIKMRVYKGNGNDTIDPNYIGIPSAKLAQPMVADISGDMKSDLLGYAWDDTAAHPTLSIWNNIADPGNPNSTELFNVRFADLQLEVPELSHCIKKIHSTQIWYLYAPAPMVSKVFNFGSMSEIKVSKWSYKQTYRMGLALLALRILVSQGKSDKIVSQNANMDVTDGDGSVDILFPVCNHNDCQIHIAYNQQMPLCDKSDDSHQNSTACRQAQNLCVADPNFKFNFDTSNEESYSIFDLKNVLANGEYIVMDDSSFKGSSPVPIRLGDYNLDGYPDLLFVTNRRALLMESVLCNNKLCTQSDADNYRRSFRLVSQGSEALSKDISNPRQAAFFDIAEDGTLDILVLQSQGSISNGVCPGYCPTEPRFPSTKPYGVNYPGATFKFTVLDTSGVKRAHQVSQLSQTGYLSLQTPYSLFGLGRTNNYIEEMFAGTTMHQVSAWHRTIFSTKESYQIRNSYSFLTNQQMYTIPQRRWKVELYIQPADYIPWVFVVLAAAAAILATVVATLNWMEKREDRLERRKALHIVNFDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PY98</accession>
    <name>A0A8H7PY98_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PY98"/>
    <dbReference type="OrthoDB" id="2394876at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2182477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="338" mass="38258" checksum="7DB559F99BB88764" modified="2022-01-19" version="1">MTDSNIANAVKYLDETYEPSNIKKQRDRTDLLHLVRSYVNDLLEQELYGKYMLPDDRCGFWPQKEVASKLGGGHKGFADVWPIDRSAHLVGVEHQHVTHSNALTDIPAEKKVADFETGLDMMISEIFGSYESEQRQSGTRDSSIFELDSDVYQQLKHNGEKETNDILDYVAKLIDQMLACKQAATQNNINWKSIGMTPPNFTAKALKHVTRPHVGVDSIDWRVVMHCAKHIGVPESVLESSQKRLEDWYAARGDRPYDISKALGDKRRTFGDKPRTSEKKPPHLPPRRYAASKEVFLATTRTPNTRSRSALQPENTMDANEETSTSKRPRLAAESASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYL4</accession>
    <name>A0A8H7PYL4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thymidylate synthase</fullName>
            <ecNumber evidence="2">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_007432</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYL4"/>
    <dbReference type="OrthoDB" id="766at2759"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.572.10:FF:000002">
        <property type="entry name" value="Possible thymidylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002497">
        <property type="entry name" value="PRK01827.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="8">
        <location>
            <begin position="24"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2182501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="315" mass="36029" checksum="ED69821629138CFD" modified="2022-01-19" version="1" fragment="single">SVSINCAAMLKSVMDNKTEEHEEHQYLNLIRTIIEKGEKRADRTGTGTISVFAPPQLRFSLKDNIFPLLTTKRVFFRAVAEELLWFIKGDTNSKHLSEKGIKIWDGNGSREYLDSIGLSHREEGDLGPVYGFQWRHFGAEYVDCHTDYTGKGIDQLQQVIDKIKNKPYDRRIILSAWNPADMSIMALPPCHAFCQFYVSTPTVEEPTSRLSCVLYQRSCDMGLGVPFNIASYALLTRLIAHVTGLLPGDFIHTMGDTHVYFDHIDALKQQIEREPRPFPKLTINRKVDNIDDFKMEDLTLEDYKPHGKIDMKMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYU2</accession>
    <name>A0A8H7PYU2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_006213</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYU2"/>
    <dbReference type="OrthoDB" id="10001928at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF2">
        <property type="entry name" value="NEGATIVE REGULATOR OF SPORULATION MDS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="428"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="620"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="620"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="650"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="663"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2183209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="732" mass="81184" checksum="FB3E0D1BDE02D176" modified="2022-01-19" version="1">MAPAMQTIADLTTRTRATTGDIPPPLVGATTTVIGNEMLVFAGRLVTTRRMTNDMYVLNLDTLVWTRFIPPPGAERPPRPRYFHSANVHKNQLVVFGGMGYSRSSEDGLCALDDVCIFDVSKMEWRYGTIAPTLYNARARYAHLSSVSGNLLVIVGGQDMNNQYIPEINVFDIEKWEWIQVRPLSKQCGAYRSVCVSADLPAGFTDNEEVADYGFGNEDQNKGTTGKRQDSLPKPMDQANYRMSYNPAATPSTTSHSPIFLYSNYNFTDVKRELQVFLPPTQTAQFQVQDRSLEMSGSALPPGLRFPTGQMLGYHMILAGTYLTPQKQAFQLWSLNVSNLIWTKMETGATLSVGSWNRGVLYEAQNQFLVFGNRDRSLLDDYNHRQTNFEHVVVINTECFGIYQPPKPSFAPIAQEMGLSMLNDPSLSDFEISTRDGITIPVNSMIISRRWPYFKKLIEGSKEDVEIEDHSKEARSLSDQEVQPVMRKKVSLSPSKRTMLIPEPYSVVFALLQFLYADNLLTAQQHQPVVLAQLLILSDMYSIPRLKELASHALHQMLTLSTATLIYETAALSNAHALQVRALKVMINAKKAMTLSTANGQKPTGLNLSMPLNQLSRSATPMLNTGLTTPSTPSFGQKEGSNYFEFPAVTQPPTPATPPPQPGSLFSLSSSKPKSPPVSPAPKKPASTKEKDSDSVSVGKKSKAQVAAERRKAQEKLLAQYGPSSFSFNFNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZV4</accession>
    <name>A0A8H7PZV4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tricarboxylate transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_006352</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZV4"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000007">
        <property type="entry name" value="Mitochondrial tricarboxylate transport protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="7"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="110"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="208"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2183347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="32208" checksum="3CF10E8AF6F3E3A4" modified="2022-01-19" version="1">MSAKKEKNATFSLVSGTIAGAIEGAATYPTEYVKTRLQLQAGGKLSPGELRFNGPIDCLVKTIRTHGVLAIYTGMSALVIGNAAKAGVRFLAYDKIADALRDKDGKLTGSRNVLAGLCAGMTEAVLVVTPSETIKTKLIHDRNSPNPQYRGLIHGTTTIIKNEGFGGVYRGVFPVMMRQGANSAVRFTSYSTLKAQAQKWRGQGDAPLPSTHTFGIGALAGIITVYSTMPLDVVKTRMQGLDARNLYKNSLDCLLKVVKQDGIFSLWKGTTPRLARLIFSGGIVFTVYEKIYGILDSKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0J9</accession>
    <name>A0A8H7Q0J9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">E3 ubiquitin protein ligase</fullName>
            <ecNumber evidence="14">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_006315</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the BRE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="14"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0J9"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16499">
        <property type="entry name" value="RING-HC_Bre1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="164"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2183310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="216" mass="25628" checksum="303EE74457ECE2A1" modified="2022-01-19" version="1" fragment="single">EDEIVSLQTQKLKHNQTFTALNKSKDVFKLLSNQLQRQNDMQLEVIRQYNEHEKNINAQMNNYDREMISVSSSFDLHQQQIAEVLANQGDIEERLNGLTSRLSDLRELIKERSKVLEDVFYQRCRIEEESELLKRRLDAMARVENPTEMKLAKEREEYKTLLKCSSCHLRFKSHVLLRCMHTFCKECLDTRIETRQRKCPNCGDSFGSNDVKQFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0X7</accession>
    <name>A0A8H7Q0X7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0X7"/>
    <dbReference type="OrthoDB" id="5771378at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052729">
        <property type="entry name" value="Acyl/Acetyltrans_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041496">
        <property type="entry name" value="YitH/HolE_GNAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47237">
        <property type="entry name" value="SLL0310 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47237:SF1">
        <property type="entry name" value="SLL0310 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18014">
        <property type="entry name" value="Acetyltransf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="321" mass="35493" checksum="C886D5B01BD76774" modified="2022-01-19" version="1">MASEIRFHQCSEADILPYFYKWAAAEHWNPGTEGRELVDVFYKSLPRSFYLAIAPDMNDPEKENVVASVCAATYGDEMGWIGFYISSPEHRGKGYGLAIFNHALKVIGNKATVGLDGVLAQVKNYQKSGFTNSVFESQRRAAKIEHFTSRLSNFETFGDTSITSIAEIPFAELDALDAKYSGFRRPTFLRNWIDFHTNKEEYGRFSCAVTENGQLLGYGCVRPAAESFRVGPLFAESPQVAKTILYHLANSVAKALSSPNQIPSTSPVLDLDICAGNANSVSLFDELEIPMSEVTTIRMYKGKQPVVDISGVYAPATYELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1T9</accession>
    <name>A0A8H7Q1T9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Guanine nucleotide-binding protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_000276</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1T9"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002307">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="65"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="172"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="197"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="222"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="291"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2184367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="43664" checksum="897B2E92D23507F7" modified="2022-01-19" version="1">MGCCQSRFDREGKFRNDLIDDQIRKDKNNLKNEIKMLLLGKLHEHTYGSYWTVFLIVLVCVGAGESGKSTILKQMKLIHDGGYSEDERMAFREIIYSNAIQSMRVILEARESLGMPLRDQQNRYYADFIMQQPAQIERDFLSSDITNALRALWKDLTIKAVFDRSREYQLNDSAKYYFDSIDRIGERDFLPSNQDVLRSRIKTTGITETCFVIGDLTYRMFDVGGQRSERKKWIHCFESVTAIIFLVAISEYDQTLIEDEAVNRMQEALTLFDSICNSRWFIKTSIILFLNKIDRFQEKLPHSPLAKYFPDFEGDNTYDEASAYILNRFVSLNQSNTKQIYTHFTCATDTKQIKFVMAAVNDIIIQKSLREIGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1Z9</accession>
    <name>A0A8H7Q1Z9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anti-silencing function protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_006230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ASF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1Z9"/>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2183226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="215" mass="24438" checksum="F24D4EE940AFD0B9" modified="2022-01-19" version="1">MSLVNIINIQVLDNPTLFTNPFHFEITFECNAELKDDLEWKMIYVGSAESAEYDQVLDSIMVGPIPVGINKFVFSADAPKLDLLPQQDLLEVTVVLLCCSYMDKEFVRVGYYVNNEYLDPTLRQAVADAIENKRPPPPLQIDKLYKCILADKPKVTRYTINWDNPQATPASNDVQMDSNDQAQQIGQQQVSFVKVIHGIGKVHDTDCWYFQDVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q449</accession>
    <name>A0A8H7Q449_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_000876</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TALE/TGIF homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q449"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000059">
        <property type="entry name" value="TGFB-induced factor homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="146"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="148"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="82"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2184963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="271" mass="31266" checksum="284F55CFA81E19A5" modified="2022-01-19" version="1">MFSSSNLHSKPPSGTRRFKTIVLFNDYQNHPDYHRMADIDSHLVKTTEMLQRNAEFWSGLRYPDIRPQLSIDTLVTRSPLTTHAYPSSSIPPRSASYTPPLLHSDVGSASDYSPSTPPEQAASLDDGNMSGSDSHPMHSKPTTANSSLRRRRGNLPKNVTTFLRNWLVQHKRHPYPTEDEKIDLARRTSLTVNQISNWFINARRRILQPILRNEQMHAASVAKKEHVNMHDFDDGATFDYVKQRKIRRLPHRSPRSTRETYRRKRTWVTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q594</accession>
    <name>A0A8H7Q594_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_002494</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q594"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12383">
        <property type="entry name" value="RRM_RBM42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034215">
        <property type="entry name" value="RBM42_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="145"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2186056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="246" mass="27749" checksum="BADDB426A2A6CD98" modified="2022-01-19" version="1">MSKSEPKAAAAAAADNQYEQTATEGTDASAYDWSQYYAQQGYDYSQYSGYYDQSQQYYYDPSTYDQTAYNNYYYPSAAASSASTPSYADTPPAPKEGLPEPISIEELNRVSNRGGASKKQPKIVRSAGGETWEDATLADWDSNDYRLFAGDLGPEVDDDMLTRAFSKYPSFQKAKVVMDKRAVKSKGYGFVSFKDADDFVKAWREMNGKYVGNRPIKLRKSTWKDRNMDVRAKKQNNRAAPYSKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q595</accession>
    <name>A0A8H7Q595_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_002650</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q595"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17998">
        <property type="entry name" value="DEXHc_SMARCAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000014">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="486"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="879"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="676"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1024"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="676"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1032"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2186212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1050" mass="119542" checksum="84E8A16199C3404C" modified="2022-01-19" version="1" fragment="single">MGETRKTQTLLQFGTPKQPNAVRKEIPSSVTPPLQQDRLGSFLRDKESKTSNKVSIRRNMKSSFLKAGRELENVRASDRSQSADSDKSNSIRNASFPNSPSNVSVSSDSSLQAFSQDFEKVHVKSDMSPRVRWDSSDDDADQQKSPTRAMPAATMSTSQNDLSPLPQRTRQLNRLKRKKRALISLESDSEDSDTNAIDGTYDLSNMGSTEDSSSGSHIKRMRKLSQNNENLIPEKHMESELEYKISRLQESFQNRRRSSIERALVKANGMQVKAASELILNEKRSKQTYVDSSPKAASPSSTAPPRAAVIAISDDSEEEEEINSEDETNSEASDTDYALAEEEMRLDQQAVQFFNNSTCQDIQDVTACNAQQAEGLSMLRPFNDMEDLQEKLRSTKGLGERFINSYKEMMQGYSAVDRLVSDIEGIGAELNNIVNSWKETTTPNEEIPDNKLLNAPPKTYIDEQPKIMSKGIALKGYQIFGINWMLLLYKRKLSGILADEMGLGKTAQVIGFLAQLISEGHKGPHLIVVPSSTLENWLREFQKFCPCLDVRSYYGSQKERVELRYDLREDKDWPILVTTYQMATGSGLDRKFLRNINFDVTILDEGHMVKNCTSARYQHLMAIPSSFRLLLTGTPLQNNLQELVSLLTFILPNMFVENNEGLQKIFKIKYTSNTMKDNEKDKKDSSDTSTGSSSVAQMLSMERIKRAKKMMTPFVLRRQKSQVHSDLPEKIHIIERCTMTERQSKVYQTVVQNSKKRLHEKVQIESNDSDNKELTELITSPIKSAECRQVNPVNILMELRKAANHPLLLRRIYNDELLRTMAKEIKREEQFWDSEEQYIYEDMSVMSDFELNRLCLEHRTIKQHALDKDIVMDAGKIQVFKELLLEMKEKGQRVLVFSQFTMMLDVLEKVLDNMDFKYSRLDGSSKVDTRQDLIDEFSENPDITVFLLSTKAGGFGINLTAANVVILYDLDPNPHNDKQAEDRAHRVGQTKDVTVIRLISEDTVEENIFRMANVKLRLDQSVSFDQNDESGSENREKDENIKSLVQSALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5I5</accession>
    <name>A0A8H7Q5I5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5I5"/>
    <dbReference type="OrthoDB" id="10476282at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034551549" evidence="2">
        <location>
            <begin position="21"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2185086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="138" mass="13579" checksum="A0F00949F4352869" modified="2022-01-19" version="1">MRAVLIGTVACTFMVVFARAQEEPAVEDTEDAPAVDADEDAGADTAAAAINTAFPSPDMSEVEGVASASGSAMSASMSASMLASVSGAIPSSMASLSGHAVSSNIAQPSTVHKESAATHTTAGITMAMVAAGLVAFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5V2</accession>
    <name>A0A8H7Q5V2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiaminase-2/PQQC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5V2"/>
    <dbReference type="OrthoDB" id="37730at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19357">
        <property type="entry name" value="TenA_E_At3g16990-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053261">
        <property type="entry name" value="Polyketide-peptide_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41813">
        <property type="entry name" value="REGULATOR PAB1642, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11955)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41813:SF2">
        <property type="entry name" value="REGULATOR PAB1642, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11955)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="1">
        <location>
            <begin position="17"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2186115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="240" mass="27776" checksum="0994FE3F0824BA98" modified="2022-01-19" version="1">MLTEQLLALDPDSYYAATEHQLLEEIGSLQLPPKNMRAWMVQDKFYTSGYINMLAKMMDRLPTQAQGTEADSDGIANEQDITKRLYKNLSFAHENIIREASFFDNLIKRYESPSTPDNINSLTQDYVDFQQRVTEESDSQLGEAVILLWAMERVFYDAWSYAGSLLKDIPASDNDSEHIKTIRELVDNWTSPDFKEFVDECAFHVNALPVDSAGQMDSYEQVFRDMLVFEQKFWDLAYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5Z9</accession>
    <name>A0A8H7Q5Z9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_002869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5Z9"/>
    <dbReference type="OrthoDB" id="2385908at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2186431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="353" mass="40887" checksum="1AE3A56C322A9E6C" modified="2022-01-19" version="1">MLIELRDYFIAAGTEMAQDMMLMEHPPLSFCILMLCLASAQMFLQKMRKAWLWACPARTYLQQHMSKYIDTSSGSHNRSNPEIETYKYALHFCEQLEFRLGAIMNEMATPNILNIDPRLTLPTKLEGDDEVEHVAFLQRLTWESLVAESKRWLTSYESINGSVKSVDWNAVNKVTKRYYDWYLHLPAALKIGEKPFDIDFDDISEDIAISVCIVQIMFYGEWMIVYSNFLSVKNILEDEEKLVESKKFAFLASRAIIKLAHHVSRHAVCRMEFFWVVYACEPLLYLLNANDKYIAEESRKSLEIAKDVLRVLLSSTNFSGEIGHHFNNSSQQNIAKNIAKEVAMMFSSYGLQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6U5</accession>
    <name>A0A8H7Q6U5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED4</name>
        <name evidence="10" type="ORF">INT43_002828</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6U5"/>
    <dbReference type="OrthoDB" id="1929813at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="189"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2186390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="239" mass="26804" checksum="FF02BE874D065A61" modified="2022-01-19" version="1">MSDAAESASLKVQVSSLLREYASLIQQYFVSINNLVDNPNLPKENTPESITERIIQVDAKLQKAVLKTLFPPVDEHQKQHGKIATIQEQIKVQNASLLLVVNRLQETRTLLAETLSGAQEELSLIKKASDANMNFSDILSYASKLSKYTSAPPNFNLTRDTKVDFEKPYPDEERMRRGILYWQHLPPEQQAQATLESSESESSEEEGGHDDAMGKVTAGVDDMQNEAFWELDLNPDLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U6W9</accession>
    <name>A0A8H7U6W9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">6-phosphofructo-2-kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_004777</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U6W9"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF39">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE YLR345W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2172236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="338" mass="38746" checksum="1C965C9DE8D7A1A9" modified="2022-01-19" version="1">MAARLYVTDSGRYFHAGTIAIITVGLPARGKTHVSRSLCRYLRWLGVPTTVFSVGNYRRQRLGTMPNDFFSPANEDTKEQRLTIAEECLSDMIDWLERGGQVAIYDASNTTDERRAWIQRKLNKHNIQTLFIESICNKQEIIDSNIRSVKISSPDTNTPFSQYVGWDPEAAVRDFKNRIENHLPYYKTISDPELPFVKLMNVGEQLIVNNVKGYLQSRIVYYLMHLHIQPRIIYFARVPESLNESSYKADADLSSDGHKQAEALKNFLVDYRKQQQESGTEDKPRPLTVWGSTRKHASQAVRHFAEDDFLVRALPLLTERNPGECDGMTAEQIKASRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U718</accession>
    <name>A0A8H7U718_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_000123</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U718"/>
    <dbReference type="OrthoDB" id="10263155at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="15">
        <location>
            <begin position="6"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="14">
        <location>
            <begin position="181"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="13">
        <location>
            <begin position="329"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2172776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="479" mass="54730" checksum="BDB9EA5F366550E1" modified="2022-01-19" version="1" fragment="single">MASAWIDHLQRQGILEDQHVEKKRTVICQHVQQIADIVTTKLANAYNVRHQPCRVMPFGSYALGAHLKESDMDLVCFAPWQLQRHDIFKGMAQQLRQVDSISALEIVERAPVPIIKFIYDESIPVDISFARIHALSLTPMVNILDDQVLDGIEEVDCRSLDGPRVHHLIESKVAVDDKPAFCAALRCIKHWAMQRGIYGKPMGYLNGGTWALLLCKTYMEIAGSRHVDSLLYAFFNQWAKWSWPKPVLLDKLHDLHGSSTTFNDLMEFQQDVMPILTPCYPYKSSNPYATYSTVKIMTRELIRASNIMNAYIRNEQASLIPKLFKPSNFYRQYKHYLNIVLCSDHVSKRQDRFKGKLAACIPKLIELVEQSPRIILAHPWTAARTSVYNYSTLEEKADVQRGVLVNDPRSYYMSGELNPGELYRLDYYVALELAPEHSTTGHNDNVVDLSSSINTFIQETKEKILLRDRSASLAVTSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7G4</accession>
    <name>A0A8H7U7G4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DOP1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_009101</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7G4"/>
    <dbReference type="OrthoDB" id="297643at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2171440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="159" mass="18462" checksum="DE99C7EE7DC0856D" modified="2022-01-19" version="1" fragment="single">EYANDPRYRKYVQLVEKNLQTFDAVNEWADIISFLGRLLRSFQAYPQYPIIPRKTTVAKRLAQCLNPGFPAGVHQKTLEVYAYIFETIEPNQLVRDMPLWSAGVFPFVQHAATHVKPQLLSIIEKYYFRLGHELKPCMRGLVIALLPVVEEEGSEYFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7L6</accession>
    <name>A0A8H7U7L6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="15">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="15">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ALA1</name>
        <name evidence="18" type="ORF">INT43_004404</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 15">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="15"/>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7L6"/>
    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070143">
        <property type="term" value="P:mitochondrial alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.40:FF:000003">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059090">
        <property type="entry name" value="ALA1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26023">
        <property type="entry name" value="ALA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 15" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="17">
        <location>
            <begin position="8"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="918"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="924"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="604"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="608"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="723"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="727"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2174381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="957" mass="106507" checksum="BD8BE746F741D215" modified="2022-01-19" version="1">MSDSDCQWSSSRVRSTFIEFFEKKGHTFYPSSSTIPHDDPTLLFANAGMNQYKPIFLGIADENTDLGKLTRAVNSQKCIRAGGKHNDLDDVGMDTYHHTFFEMLGNWSFGDYFKKEAVAFAWELLTVVYGLEKDRLYVTYFGGDEKQNLPADLEAKQLWLDIGVAEDHLLPGNLKDNFWEMGETGPCGPCSEIHFDRIGGRNAAHLVNQDDPNVLEIWNLVFMQFNREVGGSLRPLPNKHIDTGLGLERLVSILQNKLSNYDTDCFTPLFKAIQDMTGARDYTGKLGKEDTDGIDTAYRVVADHIRTLTFAISDGGVPSNEGRGYVLRRILRRGARYVRKYFNVPIGSFFSGLVGTLVAQMGDAFPELKAKVDDVVEILNEEEESFSRTLDRGEKMFDAFLNKTRQEGSKTLSGDDVWRLYDTYGFPVDLTRIMAEENGVSVDEKQFEAAQEAARTLSRNARGGKGGLEAVALDVHDLGALEKNDSVPKTDDSAKYLIGNIQSLVKAIYFKHEFPATTKDIPTEASFGILLDKTNFYSEQGGQEYDIGNIITLDGENEFVVENCQSFGGYVLHIGFMKYGQLKVDDNVEVSYDQLRRWPLRNNHTSTHILNFALREVVGDHCDQKGSLVTPEKLRFDFANKGGVTTEQLKKIEEICNNFIKKNQKVYSTPVPLPVAKAIHGLRAVFGETYPDPVRVVSVGFDVDEIVKDVSNPLWKTSSVEFCGGTHVAKTGDIKQLAIMEEGGIAKGIRRIVAVTGDEAVQAQRVANEFKNRLDKLEKMQSEKLDTEIKLVAKELDTLPISAVNKADFRTQFEKIKKAHMDAEKVRSAAQQKEMIESLDKYFEENPEAQFIVKNVDVGGNNKAIAAAINHIKANHKQKAIYLFSVANGRVMHQCLVTKDQVSKGLKASDWADVVAKQVGGKKGGKDESAQGSGDKPESVDEAIQAAAEFAKLKIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8P4</accession>
    <name>A0A8H7U8P4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_004899</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8P4"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2172357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="112" mass="12840" checksum="144CC51268C2DDD8" modified="2022-01-19" version="1">MFSKETCPFCMRAKDLLDDLDVPYKAYEFRFDREDRVVENHEVRRRLIELTKQSTVPNIFVNGKHLGGSSDLIDAHESGKLQKMLETKNPNWVDPSTVKSIPAGWSDADGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8P6</accession>
    <name>A0A8H7U8P6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_004914</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8P6"/>
    <dbReference type="OrthoDB" id="204949at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000003">
        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2172372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="211" mass="23614" checksum="CBFF26BCE37AE0F2" modified="2022-01-19" version="1">MSIMEYNGGSVVAMVGKNCVAIAADKRLGQQFMTVSTNFQKIFSATEKTYIGLPGLATDVLTLSERFRFNINMYKMEEERDIEPKTLAHMISSTLYQRRFGPYFVEPVVAGLSKDNKPFICAMDLIGCINFAKDFVVSGTASQNLYGMCESLWQPDLEPEDLFETISQALLNAQDRDALSGWGAIVHVITPERVVTRSLKSRQVSANRIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U917</accession>
    <name>A0A8H7U917_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U917"/>
    <dbReference type="OrthoDB" id="20229at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="128"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2172867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="267" mass="30097" checksum="399EE57478DDF690" modified="2022-01-19" version="1" fragment="single">KQWLNPAGEPFAPQFSDQKAFLILAGLSTWKYAVSCTAEELVSVVTLYCKAFNVIMLYYYGKKWWMMLYIIGWALIFVLFPQPPYQGTTKAVELSSSSLTKVLENKQANAKIVELDEDEQPLVDVPMAKYWVILLYANWSVASRNFEAVLAGLSLRYDGPNIKFGKVDIDLYPAVASKYHISGEAAAFDLPTLILFKDGKELTRLPQLVASQRAIKGKNTTTELSRKDAAKDTISRIGWNRSPVSEGPLVLIKRISVFNLKLLLRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U987</accession>
    <name>A0A8H7U987_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U987"/>
    <dbReference type="OrthoDB" id="27198at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.200:FF:000003">
        <property type="entry name" value="DCN1-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="145" mass="17532" checksum="737BB984B45B0C34" modified="2022-01-19" version="1">MDASAMGYFTKEEWMKGMRNLNVTDTDELKSKMPELEESLNDEKQFREFYTFTFPFAKTKTQKSMDVDMALVLWEMILKERYEHVPLFMDFIRKQSPVKVINKDQWSSFLDFCKVISFDLSNYDPLSSWPVLFDEYVEWRRENQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9C8</accession>
    <name>A0A8H7U9C8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002946</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9C8"/>
    <dbReference type="OrthoDB" id="68611at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015743">
        <property type="term" value="P:malate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020966">
        <property type="entry name" value="ALMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023244">
        <property type="entry name" value="Brefeldin_A-sensitivity_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF3">
        <property type="entry name" value="PROTEIN BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11744">
        <property type="entry name" value="ALMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02047">
        <property type="entry name" value="BREFELDNASP4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="655"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="678"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="735"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="7">
        <location>
            <begin position="109"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="935"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="935"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2171324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1008" mass="114707" checksum="D9B2BF47EC637B9D" modified="2022-01-19" version="1">MKRSITDIYDSWITKKIPLWKRVIKATIGYEICSILCLVPAVASALGAVPYLLPLGALFFHAGTTIGCQIEQIWLNFFLMIISATWCGVIGYLITLYNHARINMGIPLYDNGGSLIAAIAFFLCVFVIAYYRLKYPRLFTPSLEAFTLPFFTLTKQLDSTSYNIMMLLTIVYPPLIGGGIALLVNIVLWPETAAKNHELSLHNAFYSIRMVLRGIQNEYVIHPTVANTQNDAKQSLSQVKFKLQSDITALRKAAGEAKYELVVSHYSARWLKPTTKSIEKVASILVSTTLAVEEEKKIILVNNLAATLGHQRTMNSGGAMSLTNDNDEDKEELYESAGLRRRSNASREYLTNPISPYSTVQKIEYKQLSSIQQAVNPHVNEFLSVCNRCFCAIQYRLSRYKVFSSDQELIEQVMEDEDLSLIDNNNLKTLMTNGLNKFQEVEKIIQDGLDRCKTHPKEDHFLVYTLVFTLSECGQEIMRLDDHTKELVGKRTRYSRIWIPKVPLKNLLKKTSRLAKGSTSPATQAIMENQDAILLTDMRRTASRMHQDPRQALSDDKDEMDDMEATYGVPLQNAPGKHWWNRVLLAMMHWFQYGPTQYAFKFAISMEILALPAWLPVPGLNNWYNENHGQWALLSGMVVSNFTIGATLLQSMFRIVATIIGALWGYIALLAAHRTNPYVLSVMVLVFAGPFWFIFLGSKYPRIGFISLLTLVVIVNTGHVDMYGETTFEIVWKRTVTAIIAVLVVMVVNYLMWPIWAREEMRKQLALLLMDTGIYYFQVASLACHNDTQSRRWQTTFKETELASKSLRKRLDTVTELLTMSASEPRLTKSSFPRGVYASILDHERNILFWISHMKRSQVAQTFITTGVRDMVMNPVNQYRKEMAAAVHLYLFTLAGSLRNKAALPASLPSAEVARQHLQIRLGELWTELHQQRQSSKQIANMPANSSQDRYRGRSDKSLQNGERQMYWQTYAAGSVQVINEQEAMGELIVKLMGQHVFRVAEKNWARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9E6</accession>
    <name>A0A8H7U9E6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar sorting protein Vps3844 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007873</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9E6"/>
    <dbReference type="OrthoDB" id="5583277at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053065">
        <property type="entry name" value="Archenteron_Induction-Rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024382">
        <property type="entry name" value="Vps3844_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36853:SF1">
        <property type="entry name" value="DUF3844 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36853">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12955">
        <property type="entry name" value="Vps3844_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034954672" description="Vacuolar sorting protein Vps3844 C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar sorting protein Vps3844 C-terminal" evidence="3">
        <location>
            <begin position="312"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2177216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="405" mass="44486" checksum="C6EA0E38F7040743" modified="2022-01-19" version="1">MYMRLSLLAVAASTLSICSTAFAKSSVYIISEKDSANHIQPSNNNIPETTFSSFSILLSHILGTSERHHFNIQDAQRTFDAVNQVLSSSPALDRSNLFSNLKGSMFVSVGGVHDNEAILPTYNPALFVKDDRSSDFAELLSDHNEYHVQLSGLREDGVSRFYDGEELYVADDMDMLERFKVAYPEINVDIFDISKKADQTFVAEVDQVHNTVKDFAIARANSVKQKADYLTIHMTSLEGLLKSYGANSEQYKVAQSVVKDLFAKTLIPDFEQAYDNSEYALSTFVLSPSVKNHFQKRAPPSATPSLAPGGTCYEDINACEDATDKCNGRGSCGAVVGTQCYACTCNSTQFVGEACEIEDISSDFQLLFWTTIILIVILSGALTALFKLGSNTEAPPIIQVPTKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9L3</accession>
    <name>A0A8H7U9L3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9L3"/>
    <dbReference type="OrthoDB" id="5977668at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF17">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="62204" checksum="E064A9101148AAEF" modified="2022-01-19" version="1">MTLDTHSNIKVAVIGSGLAGLTAAHHLAGSQAEVHLFEKAPTLGMDAASISVHPEHNSSQKNIRIDNRFIDVVLFTNPHTGTDEIVHVWYVVLKNQRYYDRLTKLYKHLNIPVKPANFSFGWYSVHSPYVDSKSGAYEPLELKPQDVTEKAAITSYLLYSGSRSVGTLALYSRARQSLSAFLIWLYHSFIVTMSYFQLLILATWHHATGHLQNERHAIASMTLGQWFQSNHFHPFFVRHVFVPLFAAVCTNSWESMLKYPAADVLEYIAMGLFNESYVVAHGVEAVVKQLITPVKHVHLATEIVALEPVFQGSDDPLIRVIDADGNAYVFDHIIFATQGNQAVNLIQRYKQALMRLADSPHGPVVSRIVHSLQDQIDTLSRFQYDTSLVINHKDTSLLPRERTAWRALNMAILDKSIKLKDIKSAPIIPYPHDTTMTTHILNMTHSEIDQDIVYLQTTNPIAAPRPDTILSVSWFQRATVTLDSKAALNDLFCTCSNNSRKKTLGDRQGKARLWFIGSYAWTGIPLLEGCVVSAEKVVVEGIGRREGLDITIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9Q8</accession>
    <name>A0A8H7U9Q8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9Q8"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="4"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="503" mass="57155" checksum="407A22949AB53E8A" modified="2022-01-19" version="1">MATTIVDIPKLGKVKGKVFEKSNIRRFHIPYATVPKRWRVAKPVPAWEGELDCTQQRPECPQSAVPGDRFLQPQRVPPTYDEFNCLNVDITAPPNLDNSSLVPCMIWIHGGAFMAKTGLFDAYDPEKFVEHSIQIGKPVVVVNVTYRLNLFGFFSSSDIKSDVEQDGETVYGNWGLDDAVKAFHWVKENIKSFGGDPNRITGYGESAGSIMLHHLLLRPDITFTRAILQSGVVSVVKPVPPSSFDPVWRKLLDHYQAETVDDMRKVPAEDIIKLGFEYFIRHQPLIDGAICEDPVREYKEPGAYASLEAVIIGDCAEEGTLWSRRGDIKEIYKSYEDPVPSSLLDRFHLLYPSDVFDKDAAQAQKMVDELVGEAKFICPIDRTAKAIAKLRPEAPLYRYRVNRTIEITQDLGVHHGIDIFFIFMNDKLTKEERVTSEKMCSDWLYFAYGEKLEETSGWNRYQLDDPSVMIYGEQATVTDMETSRSSARCKFWEDVENASLQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UB20</accession>
    <name>A0A8H7UB20_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_005534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UB20"/>
    <dbReference type="OrthoDB" id="419317at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01805">
        <property type="entry name" value="Ubl_Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000254">
        <property type="entry name" value="UV excision repair protein Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF0">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="16"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2176300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="168" mass="17858" checksum="C473E3E7C24AB0EB" modified="2022-01-19" version="1">MQVPEVHSNLRITSQMKLTFKTLQQKQFQLDVDGASTVADLKKKIEETQGHPVETQKLIYSGKILADDNTVESYNISEKDFLVVMVSKPKATKASTSSTPSTPAKVETPKEEPKAAAPVASAASEGTASTQAPVSNTSQTAPAESKASSTGDETKPWNASDALGMYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBI7</accession>
    <name>A0A8H7UBI7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBI7"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="1">
        <location>
            <begin position="35"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="447" mass="50733" checksum="7B481BC959867E1F" modified="2022-01-19" version="1">MPLALPFVSGAHLSIDVPWPVVLLRSASSDISHVLSGEVILMLNRPTSATHIAIKLVGKSSTVWPEGIGPRGTKLYHEKVIHEQNIILSTETLQLQSGMHKWPFEFLMSNLLVETIEDEFAKVSYHLTATIERSGFGASKMKTRKDILLLRTEWNDNALTDNAQRDTSVNIERRLKSCEASICLEKTTASSGTDVAVDLMLSPLLKNVHLESISAVLTERRIYRLPEYQASRREFTDQDIMLKRTLDISEFATAEDGRKVTESDLRKALSSYYAQIPLSGSPFQQRLIFTLPNCLRTNHSTTFHEINFRHWLKLDIVLSRPVLPEDVLENEEKQITFDRIRLDIPMTILDCRLKEDFGALPTYHAAVMDYKLEDEAEIQGFQCPCFVAFRKTQKKCAKPHHIPGSHHMLPDLDTYPAHSPPHYDRLEGLRRFESLSSSLSHAHAAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBQ5</accession>
    <name>A0A8H7UBQ5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3 8">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_007706</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3 8"/>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBQ5"/>
    <dbReference type="OrthoDB" id="5059218at2759"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000001">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000032">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000114">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500133">
        <property type="entry name" value="UDPglc_DH_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="12">
        <location>
            <begin position="331"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="88"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="129"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="160"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="219"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="266"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="275"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="337"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2177050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="471" mass="51789" checksum="33DBCB2447C99666" modified="2022-01-19" version="1">MTVKSICCIGAGYVGGPTCAVIAYKCHDIKVTIVDLNQARIDAWNSDKLPIYEPGLEEIVMERRGKNLFFSTDVDQGIQDADLIFVSVNTPTKKSGMGAGMAADLAYIEAATRRIAQVSKTPKIVVEKSTVPCRTAQSMRTILEANSTGNIRFDILSNPEFLAEGTAIKDLLNPDRVLIGALQTPEGIKAQNALVGVYTHWVPRDRCITTNLWSSELSKLAANAMLAQRISSVNALSAICEATGADVDEVAYACGRDTRLGSKFLKASVGFGGSCFQKDILNLVWLSTQLNLPEVAAYWKQVVDMNEHQKHRFVQRIISTLFNTITNKKIAVLGFAFKKDTGDTRESAAITLIKSFIQEHARVAVYDPKVEPEQIMMDLTEPGVVDNRKQVEQHVQICSSAMEAAQGADALIICTEWDEFKDTELDYSKIYESMNKPAFLFDGRLMLDAPKLRNMGFKVQVIGKTELAGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBS8</accession>
    <name>A0A8H7UBS8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_004148</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00892">
        <property type="entry name" value="PIKKc_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056802">
        <property type="entry name" value="ATR-like_M-HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF125">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25030">
        <property type="entry name" value="M-HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="14">
        <location>
            <begin position="946"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="13">
        <location>
            <begin position="1601"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="15">
        <location>
            <begin position="1900"/>
            <end position="1932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2174128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1932" mass="219965" checksum="B56D908A5809F01A" modified="2022-01-19" version="1">MQDDADSEVEVGILKSIKDGGTLQALEKIASLLLRLGPRLKQPFIFSSLATQVVYTVSREKSVEKGNAYANFTLDVLTQLRRTHRTTAKTFMHRLVALYACIIQRITIDPSSYPITLQIEEESGISLESFEAAASTCQIMLIVFSSVMKHVPDCLCDIHPQLVSIITQTLSLVSLENLQPYHRRICADLIKHTIELLRHTTEFQSGPSEIYDIELLFEVMALLLNRLLILFEERWDDQLLYDIGTVFLAQLEKSEPFCPTTSSTLHSNTQKLINSMISLPNIPIAVMVANLANHLHQTKRQVLNAYEKQLCILVANNLTVDRQLINDIAYLYDLDLERFLSFACPTMLPHIIVERRRSGVDFLVHYLKNSLSALCLQHSFQITKHILVQLPDERYVAAIEFFETIASPNTSFQDLMNLCEVRLVYSLALDLGDMVVQHQTEVALARITKFCQLDSIPNLLSTHMLNILIRMDDLVEDIQKGETDASDIQVMKSLRWIIQQIGPGISGTILGISQCLNGHGIAVDAWKSIVDILLPADRSKHSNIIVGSLASLVCRCEGKEVEKVVRMLKILIATDGNDVEKYASILNIPNRPELKEIHELIESKRRVVPHKVMLQDCIKRAYDGDVGELEVALRTIYKILSTTDQPEPNIGILVFHDWLTDEYRSDLYTLLLELCQRHITEESVQILIAKCLGAMGATDAKRVKVDISDHRIVVKHNFVDMDENRAFALHLIQNHLHRALLESQNGNIQRRVQYSIQVLLRYCGFVAGMNGRQVSPASQRLWNGLSPVVKTAVTPLLTSALASNWTWQKKHKIIYPTSESFEQWLIDWTMSLITSSEGQAHMIFNSCSPLILTRNISLATYLAPHAVLHHVLSGRQSDILNEILSVLETTIDHSEQKRQACLQIIVNIVEHCSVWAQRMKGKTISRSQSAAIDEVVHFIDSIPHERMASAAYQCQAYTRALLDMEQHIRAKGMTNKSYKQLQRIYAHLDDPDAMAGLRIKFAPPYSQEQELLLLETNRKWDLAEYHYDKLNFDADMQLKDIYGHLNCLQKQGKYESMLSVASKFKRLDPSLSTKLYPFMVEAAWHERQWSLLNMHLAEVTEHTTSTRIAQVVACMYNNDRQGAYRSLQQARIHCIKQLASGKLKSYVGSYDDILSLQMLFELETTYAVNEELGHKAKSQSHLLMTSDWEQKLNLMPFGSKYQGPLLDLRTIALEYLKNSDQKIPIDYFLMKNDLQRCKIARKENNFDEAYKVLVNIEYQPPSTNSSNEGVMKCIARAKYLWDSGQKMDAVQFLSGQHLEPKIRLLLTRWKEEMGLLSSTELQKEYKNLISRFEKYENASLNFAKDIQNAHYHLGRYYDRLLTISEEITEEKYLEIAKYVCLEYVRTLEVGSKYLYNAMPRLLTVWLDLGTFVSNDEGGSQAEIRQLFNDVTSRVQENKISPQLWSVVLPRLVSRLDHQNTTICGALMTIIKKVFQAYPSSSVWHLIAHANISAGISSGTSSSTSVAQNASSKARAVRCERILKQTGGGEEGRKILKIVDQVKNLVICLKQLALHPYEASPSSQPITSALSQVRDIDICLPIEAALMPTANKIEDIPTISRFGPKILVMSSLQKPRRISILGSNGQEYRFLCKANDDLRKDARMMEFNVMINTFLKKDREARDRSLYIRTYAVTPLGDLWGLIEWVNDTTALKAIVQQQFEAMGKDLSKIAYLAKRELDPNNMRSVQSRILAFEKKVLPECPPVLHQWFLQTFREPSQWLAARTQFTRTLATMSIVGYILGLGDRHAENILLHEKTGDVVHVDVNMLFDRGQKLPVPEVVPFRLTQNLSDAMGLSGYEGTFRRSCEIVLRVLQENKISLLSVFETLVHDPIVEWKRYGERQVIQARAKRQLDTIERKIDATGRSIQDEVSKLIQDATSNSNLATMFIGWSPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBT6</accession>
    <name>A0A8H7UBT6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Redoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_005234</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBT6"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF16">
        <property type="entry name" value="PEROXIREDOXIN-5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Redoxin" evidence="8">
        <location>
            <begin position="3"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2173814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="185" mass="20117" checksum="1DCF6E7994C537F6" modified="2022-01-19" version="1">MIPDVTLTYVPYDANADPSACGRPIPIKTHKEFANKKVVIVGVPGAFTRESFFHAFDQRSWRCLNVFLIATCSETHVPGFIAKLDEIKSKGVDEVLIYSITDAFVMHGWSKVAGGSDKGIKYVGDANGELATQLGLTMDLSSMGFGKLRSKRFALIVDNLKLTYVGVESGGDVTESSAEDVLKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCA7</accession>
    <name>A0A8H7UCA7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pirin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_005536</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCA7"/>
    <dbReference type="OrthoDB" id="198735at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="4">
        <location>
            <begin position="21"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="5">
        <location>
            <begin position="170"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2176302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32141" checksum="E4BC8437CE5E8D9A" modified="2022-01-19" version="1">MTSRKIVQSILSREQAEGVGARVRRSIGTRALRNLDPFLMLDEFYVKKPAGFQKHGHRGIETVTYMLDGEVWHEDFKGHKGRIGPGDLQYMTAAKGIAHAEMPGGDEMAHGLQLWVNLSAKEKLNEPNYQEYLAKDISKVTPEEGIDIRVIAGESYGVHSPVKTVTPTMYIDVRLKKGKKMEQVIPKNYVGFIYTLTGSAMFGGDKHKSEAHHTLVLSDNGGTHIPVESLSNDCRFVVIAGEPIKEPIIQYGPFVMNTEQEIYQAFVDYEQGKNGFEGAPEWRPTIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCD4</accession>
    <name>A0A8H7UCD4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 16">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_004407</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Endoplasmic reticulum membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 16"/>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCD4"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2174384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="410" mass="46613" checksum="044070B25DF9DE12" modified="2022-01-19" version="1" fragment="single">QLSFPKTPPNNPPAYHTMARSHQQPSNKNEKHSILPQPNYAPLNVPLKRRLQTLAVLIWCSMMSICIFLFFFICSIPILFWLPIIIYLTWILIWDKAPENGGRSISWVRNSKAWKLFADYFPAKLIKKAHLLIRAPTHLTSRKQIWIQRKPISLGECEKGHDWLDPRVFGASANKSLDSYHPHGIISMGSFITFATNATGFNESFPGIKPSLLTLTSNFNIPFYRDYMMACGLCSVSKTSCQNILTKGGPGRAIAIVVGGASESLSARPGVMDLVLKRRFGFVKIAVQTGASLVPTLSFGENDLYEQVENDENSRLRRWQKKVQHALGFTMPLFHGRGVFNYDFGLLPHRHPIHTVVGKPIPVPKDAKDRPMDAVVNELHEKYMDALQDMYDRYKDVYAKDRIKELEFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCE6</accession>
    <name>A0A8H7UCE6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCE6"/>
    <dbReference type="OrthoDB" id="2266750at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36050">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36050:SF1">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="416" mass="47369" checksum="80E289785AF14A4A" modified="2022-01-19" version="1">MPRSRHVLAMLLVIAIITTGFFLSYDDVHRPQIVVNHDQTKFMVPLSGQQPISAQQPKEETYLTYLPHSGFHSQLVAFENAIMMAYYTNRTLLAPMLRLGTSFDFAPFDELRHSYLTQNISNQDAILIPWSSLFDLRPLLNNYNVRILEKTEKPSDGISDTNLGVNPSDDMIYFVNSSQELRSWKFYDKENNASPLGAYKEKWTLQQVKNIDKPLLYFGSMFGRGRVMATVPEHQAFQRFLRQQFKITHPGLKETADRIIEVLGGPSQYVGLQLLSPASGKVKQQHVIEESIQSLLTELDLDEMQMGDNDVAGRDCLDDQQSPKLYLATDLTLPASNPVLTRLRRLFPCTIAYQDLVTWNLLNDKLQDVKDEQGNNVGHFYIPLVDGIVASRAAKFFGQQGSGFGQFFQQAWQLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UD02</accession>
    <name>A0A8H7UD02_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS0</name>
        <name evidence="10" type="ORF">INT43_008653</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UD02"/>
    <dbReference type="OrthoDB" id="414863at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000017">
        <property type="entry name" value="40S ribosomal protein SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032281">
        <property type="entry name" value="Ribosomal_uS2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16122">
        <property type="entry name" value="40S_SA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS2 C-terminal" evidence="9">
        <location>
            <begin position="202"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2181071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="278" mass="30367" checksum="2C0AD2FF6323BF96" modified="2022-01-19" version="1">MSKVPAILNPTEEDLQLLLSAQCHLGAKNATSVMSSYVYKRRNDGIHLINLGKTWEKLVLASRVIAAIENPQDIVVISARPYGHRAALKFAKYIGAEAIVGRFTPGTFTNYITRSFKEPRLIISTDPRSDFQAIKEASYVNIPVISLADTDSLLQYVDVAIPTNNKGKHALGLIYWLLTRQVLRLRGTLEYNQPWDVMVDMFFYRDPEEAEKEAAAAAAAAAEGEADFTAAQESEWAADINAEGPAAIAGAADWTAETSAADWAEDATNAQASSSWDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDT7</accession>
    <name>A0A8H7UDT7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDT7"/>
    <dbReference type="OrthoDB" id="2352320at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="185" mass="21194" checksum="63E444C49559DCBC" modified="2022-01-19" version="1">MACLETRPSQQHTTAHLLSDQSDPKLDDAVKQLLQNYMAPLPSQLPKHQHQYHHRRNLSVDLRQQTRHHSPKRTSTSWLSNNAGFENDHFHAKQHVPIKRSSTPVQPSMPEVLSPKPRRFVTFEDEASQVIRTIAVSPEPISNTEARDQSVADSNEPTKPQQRQKGLKALFHFEKPKILVKRATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEW4</accession>
    <name>A0A8H7UEW4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">F-actin-capping protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_001927</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the F-actin-capping protein beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEW4"/>
    <dbReference type="OrthoDB" id="9979678at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001698">
        <property type="entry name" value="CAPZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043175">
        <property type="entry name" value="CAPZB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019771">
        <property type="entry name" value="F-actin_capping_bsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA ISOFORMS 1 AND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01115">
        <property type="entry name" value="F_actin_cap_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00192">
        <property type="entry name" value="FACTINCAPB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00231">
        <property type="entry name" value="F_ACTIN_CAPPING_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2179077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="257" mass="29221" checksum="A61DB80A058445B8" modified="2022-01-19" version="1">MRRLPPQNVEENLSKLLDIVDADLGDDLLSAIDQPLKVRRCKQTGKDYLACDYNRDGDSSPWSNEYDPELPDGATPNPTLRKLEVHANEAFDTYREMYYEGGVSSVYTFEIEDKFAVVVLIKKVGEGARRMKGAWDSIHVFEVQERGRNAHYKLTSTVMLYMITNKPELGHFNLSGSLTRQAEQDYPVDDQSAHIVNIGRMVEDMEIKMRNALQEVYFGKTKDIVNDLRSVGSLKEGKEQADIQRELVGKLMLRGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UF10</accession>
    <name>A0A8H7UF10_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PHD finger-like domain-containing protein 5A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UF10"/>
    <dbReference type="OrthoDB" id="10248186at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005345">
        <property type="entry name" value="PHF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13120">
        <property type="entry name" value="PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03660">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016468">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12367" checksum="C38C50CC257EF47A" modified="2022-01-19" version="1">MAKHHPDLIFCRKQPGIAIGRVCEKCDGKCVICDSYVRPATLVRICDECNFGSFQGRCVICGSQGVSDAYYCVGCTRLEKDREGCPKIINLGSSKTDLFYERKKFGFKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UF88</accession>
    <name>A0A8H7UF88_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein JIP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">WD repeat-containing protein jip5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008394</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UF88"/>
    <dbReference type="OrthoDB" id="2288928at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF20">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24796">
        <property type="entry name" value="WDR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="93"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="134"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="301"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="301"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2180815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="389" mass="43700" checksum="F3F82F1003788683" modified="2022-01-19" version="1">MPVPEVIKFDNQVFDFAFHPTEDIVTAGLITGHIESYRYGLEGNENLWKQRLSKKSIRGLEYNIDGSMLYSISKDKSISAIDSITGATKLKLADAHEEPLNTLLVLNENMLATGDDAGVIKLWDNRSQKCTMTYTEHDDFIADMTYQKDKKTLIAVGGDGFLSTWDIRKPNVAAMSDCMDDELLSVELVKNGKKAVVGSQDGVLSLWTYGDWGDYSDRYLGHPSSIDTICKLDEDTICTGSSDGIIRIISILPNKFEGVIGDHGEEFPIERIRLADNKKYVGSCAQDNGIHFWDVAHLFEEDDEEDEDSEEEVSADRDVADEEEEVVKADDEDDEQPVIKKDENDGSEDSDDSDDEDTKKQKRKRNKKAEERAAKQPRKQVPSGFFDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFP0</accession>
    <name>A0A8H7UFP0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003416</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFP0"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12283">
        <property type="entry name" value="RRM1_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12284">
        <property type="entry name" value="RRM2_RBM23_RBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029123">
        <property type="entry name" value="RBM39_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01622">
        <property type="entry name" value="SF-CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15519">
        <property type="entry name" value="RBM39linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="239"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="337"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="478"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2178163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="556" mass="63118" checksum="D2B6F919DE24F87A" modified="2022-01-19" version="1">MSRDSCNEPSSSQSSVKETSHESTPSTTPITFSPSEPNVPPPSPMTKVSTPNDGERLPVGSGLARGPASESKKKLLSSESFEEDYTCDCRNFQEMDMDVEAMLEAPYQEKPQVEESASHPSNGHSDSRYREDEKRSSSRHSASSRPRSSSRSYRDDYRSDRHRSRSRHSSRRHRSRSRDYRQSDSRERDYYSSRRPDSRSRRRRSRSPRRRSRSRERPDRRRRNRSASPPIPEEERDKRTVFVTQLSVRLENRELEEFFSQAGKVRDAKIILDRNSRRSKGVGYVEFYEEASVQNALAMSGQKLLGIPVQVQVTEAEKNRLAMQAQNAAYGQDISYHRLYVGSIHFKLTEDELRQIFEPFGPIDSINLHTDETGRSRGFAFIQFRNGMDAKQALDKMNGYELAGRNLRVGLVNEKTGTAGNYSLDEEETSGISFNSTSRAELMQKLAARQSDLSPQAPVQKPAPPPPKVNVPTAAATRTIMLNNMFNPAEETEPNWVQELEADIKDECSQYGQILHVNVNDDSLGEVFLKFDNVQSGERAVKALNGRWFGGKQAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFY2</accession>
    <name>A0A8H7UFY2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFY2"/>
    <dbReference type="OrthoDB" id="3210850at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="335" mass="37715" checksum="59637019F43ED228" modified="2022-01-19" version="1">MNSTENSASPSATSQPDAEELASQILSLFSISVLSLIMGNKTSETRFGEMSVSRILIMALYFWSWAFTVIATILVPTNNHNYTSCILTSYTCDVFYAGTKMIIYQWLSERIWLVTAFKTSRMKTWQYKFHLFLQMPYAVLFVLGVMYRITRINDDGTCSLGLYPTASIPLMVYDFVFNLYLTILFLKPILTVNRGLRANRKGSGLYRLAKRTLVSSIVCLLVSLANLLTLVVLGGAERGVTCLMFCTLDVTVNVLTIHWVTSGHDSKKQQNTTKQAANVSRSNDDDDIAAYKSAIKVDVQVMPDKEEDYVDEDVHSIQDSHTSKKALNYDEDEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGJ0</accession>
    <name>A0A8H7UGJ0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_000869</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGJ0"/>
    <dbReference type="OrthoDB" id="442680at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049555">
        <property type="entry name" value="GDT1-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01214">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034727165" description="GDT1 family protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2184956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="327" mass="35834" checksum="ECCE5767592683C3" modified="2022-01-19" version="1">MSHRVATALLVLTALALVNAQVDELQGTSFYDPDLAEKTLLEEPGSSGIMVDQTTKSSSLDQQGFMLSFLMIIVSEIGDKTFLIAAIMAMKHSRLVVFAGAFSSLFIMSVLSAFLGHVVPNLLPVEYTTWMASILFLCFGIKMLSEAYHMKGDESQEEMAEVEEELMEAEDRNSLRKINAEEVGGMDATTNEKKTEQFKDGVINLMQLVFSPVFVQTFILTFLGEWGDRSQISTIALAAANNVYTVTTGVVIGHSLCTFIAVMGGRYLATKISVKTGMYLRLCGNTCLIGSCFSHHSSVTYVGAVLFVIFGFVYLYEATHPHAGQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UH99</accession>
    <name>A0A8H7UH99_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peroxin/Ferlin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_001959</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UH99"/>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052816">
        <property type="entry name" value="Peroxisomal_Membrane_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="7">
        <location>
            <begin position="302"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="385"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2179109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="430" mass="49002" checksum="7415B9D628A80059" modified="2022-01-19" version="1">MGDERSSIFTDSDRESLSRFSTRSEVSGITSSRQDRRKKSGGFDSDTNASPLRAVEDLSLSKPPTPTTGKSHRKVIQQQFQDSMAQATLNGVWNHNIQILSPRATGKVFSKFVSRATPITHAFSYINNVYQWQQPVVSFSYLILWTLLCLYPSLTLLISPLIILLIFPQLKSEKSLSNALLPTCTDETSQQYFQNMKTTQDILTSAILLHDNLTKWLSRIDRYNSKISLIAFTSSCLISSLIWMFGRELLILAGMLVLVRHTRVWIIGQKLLGVVLEAIQTLIDIASHFGLVKTNPARAADPKTIEISVFENQRWWAGNGFTGQLLRAERKPWTNLTGAEPLVAKEDLPPPKGYRWLDSEWKLDRMVEPDDEGWVYTDHKWENERRLGDSPEPPMNSSASVHSQKEGRSRSLTRRRRWYRTATKINKGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHL8</accession>
    <name>A0A8H7UHL8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003962</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHL8"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2180173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="444" mass="49011" checksum="91657BB42ECCE796" modified="2022-01-19" version="1" fragment="single">YYQSKNSINSTIFATEIPLDTNIPIQECSIPEVQALVSSAMAAIRILTSIAVLVMAGWFGEESDYRGRLFVLRVAPVGMMLSTVLMIVVALYQEYVGIWLIFLAPIIKGIFAGEHIVFSAFQAYISDATTPQNRTLYMSFMMATLYSGLAVGPIAGSWLIKATGDIMSVFYANVTVEFLFFLYVLFLVPESNFYVGTHPNKKRKTFVQRLNIFSALNIIVRTRPQHATRYALWYMTSIMFMTTMIMLPPTLLYAMLRFGWTAYEGGFYMSMQSFTKLMALVVVLPIITRIFKRKNQPHRKDILFDAWMMRIGYAVDAIGLIMMATAPDVPTFYGAGAVQALSMVAQPSTKSLLTVLVKPNEVGELFGAITVVDAVAGIISQFFVNALYAATVKTMPNVVFYACAGIAAGACLAACFVHPKSDNDDGLVPVDIPDVMDAETSNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIN2</accession>
    <name>A0A8H7UIN2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIN2"/>
    <dbReference type="OrthoDB" id="2355444at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2181208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="367" mass="41540" checksum="F5485EBD2AC03651" modified="2022-01-19" version="1">MTAEPTRSGTPGRNNLVIQRDFHGRLLLCDHIRNTMITAEDWIAHERYRVGQDIQPRHCDDYDMLTQIIDDVFHLQQESYDSWVNNKTDRIPVKAPLDSRPALIVKACSDTTGDEMSQLNTPNLSPTSVDMTSQKERQSSPDHSLPQTPSPVQSPVPTSAKNINTHVWKSPLHRLYFYSSKVAGCVNVLLELESLHKLCESWETTTNNLHAFQAILSNHVAALIQSIALDASENSDFATMMDIRAELILYLESKHNWSMMSGRFTGNFNLVSFMKLVTEAQRDASVSSELDQISESDSNHQIIRPGKRRSLHSSSEDLRLDAEVSSEEVFKKKRQESISALQERLHKMKVEIEQTGLAKMHPSEDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIQ5</accession>
    <name>A0A8H7UIQ5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIQ5"/>
    <dbReference type="OrthoDB" id="2384350at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="92" mass="9966" checksum="939F0F85790EA07B" modified="2022-01-19" version="1">MPGPGTIFTIGAVGAAGAAAMFNRRNSAGAVADQDNTNMSPHALGRRRSSADKDLSFSESRKMGEYNWRRHYGANFGHNSSKEFPKDTNMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIU4</accession>
    <name>A0A8H7UIU4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Triacylglycerol lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_008971</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIU4"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF5">
        <property type="entry name" value="LIP-DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034432825" description="Triacylglycerol lipase" evidence="2">
        <location>
            <begin position="29"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR029171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2181388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="47030" checksum="84DF2313B5706FA6" modified="2022-01-19" version="1">MHTLSFGRIVYALTFVTVLLSAAGSAKAVPVRRSEPPPQDDPFYTPPSGFQSSAPGTILKTRVMPSPLVGLSSFTENVAGAWQFLYRTTDALGNAIATVTTLIEPHNADPTKLLQYQIAEDSASQQCAPSYELQSNGSGTASVLDVLMMDAALNRGWYVATADYEGPNSVFTCGLTSGQGVLDSIRAVLSSTSTSGLKSSAGVVMWGYSGGALATGWAAELQPTYAPDLKLLGAAMGGTPADVNATVNAVNGGLFAGLIPAGILGLAQQYPDLNTYIQSQLIPSKAAAFNNASKQCAAADLQQFANQNIFSYFSNPNVMNAPVAIQAINASHMGSYQPKIPLWMYHAVHDEVVPFAPALAVVKKYCSEGSTITFTQDEISDHIILAITGAADAFNWLVARLNGTAVTPGCTTRTTATSILDSGALVTFGSIIFNGLQSLLGRPVGPTSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKC5</accession>
    <name>A0A8H7UKC5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_000855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKC5"/>
    <dbReference type="OrthoDB" id="10249245at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2184942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="71" mass="7957" checksum="4DE8A67B86863AA4" modified="2022-01-19" version="1">MIDQKQIIADRANVTAALPKDVPRYAICKFPFNDLEGYPQVALIYYVWLANDANIGLKLNTKTTVKLFPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7ULI3</accession>
    <name>A0A8H7ULI3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_002625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7ULI3"/>
    <dbReference type="OrthoDB" id="74807at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21437">
        <property type="entry name" value="zf-HIT_ZNHIT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039723">
        <property type="entry name" value="Vps71/ZNHIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13093">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="6">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2186187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="160" mass="18182" checksum="BEA2FA8D91ACFE6F" modified="2022-01-19" version="1">MSKKLPDRGKTAKAAYDPEAQQKHLRRHLESLERDNHQPLDDVEGLVSVALAHIDDDGSGRKRQKVSRANPFSTRQNLNTLISEARLDLLPPDIPTYMTCNAAPSVYPPRQFCSVCSFQSSYKCSKCGMKYCSVKCLRTHEETRCMLFLFLCFCFCFSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7ULV2</accession>
    <name>A0A8H7ULV2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_006570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7ULV2"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000032">
        <property type="entry name" value="Krueppel-like factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="304"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="336"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="367"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2183564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="399" mass="45292" checksum="741D5595EE5762A8" modified="2022-01-19" version="1">MSNSLQQQQQQQQQQQQLCDYSLPTMENSFEPDFVDHVLYGDDQPQDSLHFSHGKNSSDSSPSSSFETEWESHMLSRKSLARLENIAQTPAMAKTSYIPPSQRNLLNSPLDLDMSLCDTPQSFWETPMESPMTMFSGTPYVPPTPFYTPMVNGQDIALDHCEAMGKSPFIADEGYYTSHMSPYPAGFDGNPLSLITDKDSILGREPNHQIVYVGEQTSHIDSNSNSLFVPLDDCMSGNDDNGAGSQPSSQTCLFDVVDEQEIFGSQDEPNSDYKDDDYTPSPVTIKRKRTSSTRDVTGRPLKRFECPREGCPMRFSRRFNLQTHMRVHDPNRDKKFRCDIDGCGKNFDRRHDLSRHEATVHRGERAYHCEYCEKPFSRKDALVRHVTVKGCPNQPLAQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UM03</accession>
    <name>A0A8H7UM03_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7514 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UM03"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055936">
        <property type="entry name" value="DUF7514"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24355">
        <property type="entry name" value="DUF7514"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7514" evidence="2">
        <location>
            <begin position="186"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2184688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="429" mass="46489" checksum="AEFB2CC4CC5C3747" modified="2022-01-19" version="1">MQNLGNEKKALPPNPSVQHDQGSTEVPQSRPHQPGYPRTAQGYSPSQNHPGTAPQHYPGQQMPSPQSGPPPMFSPEHSQGYPPQPLSSPQYNQQHSPNGPYPSPPANAPYPPSPHGYQPPPGQYQHYSPQNTYPQGTPYPQNNSYPQGSPYPQSPASPYPQGYPAGTPPAVNPNYQHRQSLSGPRPLFDEYGLPTELMQKYSMAIFNYLDANYAPKNTRAIEQSKIKAFMEHLGIDKNRNIGALPSNVLEDFYNHFGIAFTKTMAPPSIDGAIKVASTVFKGASFLANVIGAGTGGGGGGLLGGGGLGGGFGMGGGSSSQANLMIPTIDSNGFTTLFSNAIKRNPNGMFQKTNEVIQRFGIHLPPLQRPQLPYGPDPVVVEQYKTYEQMMMMKMKMKMQQTQMVAQVAINGAHNVQQASLPAGYYYKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCE6</accession>
    <name>A0A8H7PCE6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Laccase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_002919</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCE6"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13851">
        <property type="entry name" value="CuRO_1_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034151085" description="Laccase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="29"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="151"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="359"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2171297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="572" mass="62650" checksum="16E70D1F475262FD" modified="2022-01-19" version="1">MKFLNGCMAGALALASIARAANVTLDWDITYTNANPDGLFERRVIGVNGAFPPPPINVTVNDTLIINTHNSLDVPTSLHAHGMFQNGTAYMDGPVGVTECGIPPGGNFTYVIPITQKGTYWIHSHYRGQYMDGLRSALILHDPTPPYQYDEDIVVTMNDWYHDQSETGLATFLNVYNPTGAEPVPNSGLINNNANTTFNFVAGKTYRLRLINMSALAMFYFSIDNHTMDVIEVEGVDTQRKTVTNIFLAAAQRYSVLVTAKNDTSFNYYMHADMNPDMFDVVPDDLQLNITAPIIYNQNAAFAPQNDLGSLEFDDTTLVPLEVVGMAHADHSYPMSFDFQVYTDGINRGAFNNVPYLMPKTPSLLTALTIDQQYANDPTIYGSQGHAIIAPHLSMMEFAVNNLDSGAHPFHLHGHVFQVVARGDGVYNASANPVNETQANPVRRDTVHIPENSYAVIRWRADNPAVWFFHCHVEWHLESGLAAQVIEAPELMPQRLQPPQQLYDNCKALGWSVEGNAAGKQGLDISGAPGGVTIPYDGFTAKGKGAMAACIISALLGMGTIVWYAQGQVGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCJ7</accession>
    <name>A0A8H7PCJ7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ESCRT-II complex subunit VPS25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_009023</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCJ7"/>
    <dbReference type="OrthoDB" id="245150at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000141">
        <property type="entry name" value="vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2171362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="206" mass="23558" checksum="9EE9136C1D039D2A" modified="2022-01-19" version="1">MSSPKLNSGSSFKFPAIHDFPPLYTRQPTEATWQNQVKEWERIILAYYRTHRLYRLNLVEDTVPGASPVFDNQRIKRRLTFETLEEIVNEMVRKGTLGRKPICVAEWVSDTKSSAKISHTQALIYWRSPDEWASLLWNWINERGLNNSIMTVYEIANGELAEGTEFYEMDGTILMRALEVLSAKGNAQIFTGTGDVDSIGVKFFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCV9</accession>
    <name>A0A8H7PCV9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">V-type proton ATPase subunit d</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7 8">Vacuolar proton pump subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_002956</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCV9"/>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.50:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000003">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00059209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2171334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="411" mass="47001" checksum="D02E402186F2B5D1" modified="2022-01-19" version="1">MIAALLEAFVLNKHLLRNVSLEFAGDQFREMSGGQNVFMIHFLLQISPRATSTPAQRSQKSSRNNMAGATTWNTDNGYADGILRGYKSGILNSAHYLNLTQCETLEDVRLQLSATDYGTFLQNEPSPIATSTISEKLTQRLVEEFDYIKCQAVQPLAKFLDYITYSYMIDNVVLLITGTLHERDTHELLDRCHPLGVFDSMPALCVATTVSELYNTVLIETPLAPYFKDCLSAQDLDELNIEIIRNTLYKAYLEDFYDFCQKLGGPTAEVMGDILEFEADRRTINITINSFGTELPKEDRKKLYPNIGRLYPQGTSALATADEVEQVKQVCEAIPEYREFFDQTISESTMEDRFFGFEVFLNRLAFQQQFHYGTFYAYVKLKEQEIRNIVWIAECISQNQKDRISSYIPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD09</accession>
    <name>A0A8H7PD09_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Set1/Ash2 histone methyltransferase complex subunit ASH2-like winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_009091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD09"/>
    <dbReference type="OrthoDB" id="4080456at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053835">
        <property type="entry name" value="ASH2L-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21198">
        <property type="entry name" value="ASH2L-like_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Set1/Ash2 histone methyltransferase complex subunit ASH2-like winged-helix" evidence="1">
        <location>
            <begin position="77"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="183" mass="21605" checksum="8DF420FCAEA6818F" modified="2022-01-19" version="1">MTKTRIVIAAKAMTREGIPMIQCAQCAQYFHRDCLKCLPKPLLFGDIFMEFTCSVCTKTEEKYVRHSMAWITVVQLVLYNLMRRQDPDTDYPKDRDHKYFRWKEDLCAFIDDYWEYLHPGKQKSATWHNTIASVLSTNSSIFLSGFEKFQQPGDAAWWTLKDYSPPAKSKSYVCQFPYHIRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEA6</accession>
    <name>A0A8H7PEA6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEA6"/>
    <dbReference type="OrthoDB" id="2279863at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2172362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="195" mass="21485" checksum="D8412847DC38B5DE" modified="2022-01-19" version="1">MAFDGAEADKANYEKFKSDADNCGGCENVFKSLTLVYYHCKGVDQMLSIAIVKPNIATIILDELNTVEAVDIVALVSYMFPESVLLEDWNINVDNRQPGVFMARVAQIKICERYGSLGAAGFRVPAGGRCRRVLRRKASAVRPDANTLATPQKESAITLGYVEAKPEDSMSNPELGYVDLVHLGTFRRKPHAQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFT5</accession>
    <name>A0A8H7PFT5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFT5"/>
    <dbReference type="OrthoDB" id="2155101at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024242">
        <property type="entry name" value="NCE101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28011">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28011:SF1">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11654">
        <property type="entry name" value="NCE101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2173118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="71" mass="8432" checksum="7D2768FEA911DBC2" modified="2022-01-19" version="1">MVKYQYIISKKGDIVFSIAVGTAAYFMYERDNPRPEGKSLLELLNRRRVNLIQEREAMRQERLEKLRAKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFW2</accession>
    <name>A0A8H7PFW2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SLC41A/MgtE integral membrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_004578</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFW2"/>
    <dbReference type="OrthoDB" id="666972at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000001">
        <property type="entry name" value="Solute carrier family 41 member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF7">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="127"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="298"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2173204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="439" mass="48094" checksum="B2F149C6CD41F4A9" modified="2022-01-19" version="1">MANNSRTEAIQLRATPIETIVEDEDLEIGQTHSNGYMPVPTSSNKRQSRHSRTESGSSFKMFTSTYVPETIDETAKDVSTSDPHHLASQALPSLLISVAGLVIAGWLMDIFQHWTVFTQVSELFILVPVLLNLKGNLEMNLAARFSTSANLGDLDNKTTRNALVWGNLSLLQVQALIAGSIAGLFSFILGLVTHPEDANSLPESMLMISSSMLSAAMSSFVLGVFMCALIIISRMFRINPGNVFDNIACPMASSLGDVVTLVILAGCSHALLASLGNLAGLVLERYVEQYKGLAMLTPILDGLAGNLGSIYASRISTSLHVGRVEDYKRVEWTLLAMNIPVQVVFLLIIWLLNLGHLDFTIWFFLTYFLVSMLCTWLALKMGKFMTLAFWKRNYDPDNYVLPYLTATIDVIGTALLVASFSLLTSNELANMAAEPVNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PG29</accession>
    <name>A0A8H7PG29_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Myb-like, SWIRM and MPN domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_004594</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PG29"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="155"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="155"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="MPN" evidence="3">
        <location>
            <begin position="381"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2173220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="655" mass="73169" checksum="81317887ADE663F1" modified="2022-01-19" version="1">MPPKKKQAGEAMTHAQEEEMSSALIAQLLAEDGMDQDTGGYYAEYGNDRGTYDQYRKHDTDDSYEEESDDDFRPKYGGAMGTRGRRGRGAKRGSGSRGGGAPRGRKRKAISEPHVDGVDKDVAGQEAPKDGETADVDVAPVISEKKEKKPKRPLAEGMKTGTYDDDEEARFLEGLEMFGRDWSKLAAHIATRDPNSIRSHAQKHFIKLYRDNIPLPDKVKETGLGYTLSGKELDPNSAAAKPYLSRQGASAGNESTTATDMEKKAPDLSPKTENQVGNLAVGTMQESDTKIANTAATPIKPVKAAKQPNLKPPSHARFQDAIYDEDGRTSYSKSRLRQPRERSSISFSQLNGDTDPLTMIKCEPFCGKPASGVAGCQPFEMKMQSNVLVAMDFHAHLMTTEIIGFLAGKWDKEKKHMMVQAAYPCRSLNTGQNDVNVEMDPTSAIDVRQKIEDQNMQVVGWYHSHPTFVPDPSLVDIENQKSYQTQWRDTFGEQTLEPFVGAIVGPYDPKLPGSVSVINWFYLDSDQLIPKRLTYDIEQDMGISVEESERMFALLDEYKHSPEKVHFLEFWRQDAQESKLQKLIKSLAKRMPWLQAALAHVTRQQNEALSLPIVEQAAAPTGQQNGVMMEKDPLTGLDIVREMFLEQVEERLRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGT0</accession>
    <name>A0A8H7PGT0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="3">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_005117</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256524at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046939">
        <property type="entry name" value="TPPII_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048384">
        <property type="entry name" value="TPPII_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048383">
        <property type="entry name" value="TPPII_Ig-like-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022229">
        <property type="entry name" value="TPPII_Ig-like-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046940">
        <property type="entry name" value="TPPII_Ig-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF14">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12580">
        <property type="entry name" value="TPPII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21316">
        <property type="entry name" value="TPPII_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21223">
        <property type="entry name" value="TPPII_Ig-like-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="37"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl-peptidase II first Ig-like" evidence="11">
        <location>
            <begin position="531"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl-peptidase II galactose-binding" evidence="12">
        <location>
            <begin position="669"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl peptidase II second Ig-like" evidence="10">
        <location>
            <begin position="810"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2173697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1283" mass="141410" checksum="2AB1A06D74431E9F" modified="2022-01-19" version="1">MPQHLPHPIEQYPVHGLLPKEETQAAAYVKKYPEYDGRGTVVAILDTGVDPGAAGMQVTSDGKPKIIDMVDCTGGGDVVTTSVAKMTEQVINGKSRKTLQGLSGRTLEIGPEWANPSGEYRLGLKPAYELFPKELVNRLKQERKKVFEKRHIELLVGCQNNLVKFDRENPNPTSEADQLARSDLEARVEALKAAMKSYEDHGVILDCVVYHDGNDWRAVVDVEGSGDLTQQPCLTDYRKELKYHTFGKSDLLNFSVNIYEDGNLLSIVTLAGSHGTHVAGITAANFPDDPALNGVAPGAQIVSLRIGDARLGSMETGPGLTRAATHLAVNKCDLANMSYGESSGLPTDGHFIKLMAEEVISKAKCTFVTSAGNTGPCFSSIGAPAGMWHSFITVGAYVKHSQMQAEYAMLETVEEQPFTWSSRGPCTDGFKGVDIYAPGSAITSVPKYGLTKLELKNGTSMSSPNACGCIALLLSGLKAKKQPSTPFRLKTAIVNTGKQVDDPLHVGFIQVDQAWEYLQKFEERKDLDMLFQTRVARNGGDRGIYLREPEDTFRVQQVASSIVPTFLGEADPTNPVYSEDRVSFEARVAMVTTQPWIRAPNFLYLHANGANFDVRVDPTQLKAGEFHFGEILGYDTTCPDRGPLFVLPVSVAKPIVPTNASFRAKNVTFEPGVTQRWFVAVPAGTTYCELTIQSAPSQVTSAARFMLHALQLVPKKSQKTKIAYGMFLGRGSYSDPEADAQMIKKRFAVVGGLNLEIALAQFWSGLGSHNVDISMDFHGVQIAGNLSDGNGAITLSPQITRLELQAPVRREEEAELNVTFDTLRKHVRPTSATIAPLDKERDRLPNGKQVYGLTLTYNFKIDNNNTSLVPDIPAVTDQLYEHYLSGVFGIIFDANQKVLNCVDVFPSKIKFDKKGDYTLRMQLSSEQEDVLDKLKTTLLHLDISMGKNISFLTHKTVGDVYNSDKSTCSKMILEKGDFKVCYVAAPHDHSNYPKEAKTGDALIGKVSFTSEKVDGGQYKAVYYIPAPPNEAAQPSNDKEEDSELQQKMQDAIKDLQISYLKKLSAGSEPRNKLLEQLEKEQADYIPFLEYKLDTLVNVDTLLQPSSSTSNAEEANKVACNILEKIDLKSLAEYFGVRDENKNGKRKQLRKDNEKKKQTAVNALKGKCIALSVLLDQDAKDSAKQQEFETAFRELQQWSDSPASTSSDVVTVLLFVAQERRAKRYGSAVKALNKLTAESSDPASLNKAFKVHQEVLADLDWTLWQEYHSQWALIRNPPTGFAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PH77</accession>
    <name>A0A8H7PH77_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_005208</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PH77"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="37"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="531"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="533"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2173788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="558" mass="61052" checksum="075AD38D27234D7E" modified="2022-01-19" version="1">MGPIVTPKDEKREGDDTIKRPGDDGVRSEAGWILYAVTAFAAIGGFIFGYDFGVTSGVLVMPAFQDYFAPLTPDKKGALNSLMGTGAVFGCLFAGTASDWRGRRDSIGFFALVFVVGGVLQCAAQNLGMQLVGRFISGISVGACSVLSPLYMAELAPKEIRGRLVAFQQLMIDIGLFVSSWIDYGTGEINGDWSWRAPYGIQIIPGLILALCPLLLPRSPRWLLEKGRKSEALAVLARVHGNGDENHAYVQREFQEIQDNVELENQLAVKSYIGMLRDPANRRVLWVGCSIAIFQQLTGANVIMYYATLMFEQAGFTSSASLLANGIDYALMVVFCIPAMFIVDRVGRRKLMITGTIAMGIGFVLMAGIYGGVGHTVWDPVNLTHAVDMDGNRGADYAVIVVIFVFVCFYAITWAPCAWIYIAEIFPLRIRSKGFAFASALLWVGNVLVGQVTPILMNAITFWTYIIYAVIAIIICGFLYFFSPEPKGLSLEEMEVIFQGPVFVNNLDYDAYLSAHRADVERLRAEVQAAKAKTHENGTSDFKDDEKAADGHSAGQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHK9</accession>
    <name>A0A8H7PHK9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calcofluor white hypersensitive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_004136</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHK9"/>
    <dbReference type="OrthoDB" id="68581at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000031">
        <property type="entry name" value="Calcofluor white hypersensitive protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057315">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051916">
        <property type="entry name" value="GPI-anchor_lipid_remodeler"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053912">
        <property type="entry name" value="PGAP2IP_TM_1nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053911">
        <property type="entry name" value="PGAP2IP_TM_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859">
        <property type="entry name" value="CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859:SF1">
        <property type="entry name" value="PGAP2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23022">
        <property type="entry name" value="6TM_1st_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23021">
        <property type="entry name" value="6TM_2nd_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23226">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="546"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="633"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="670"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="2">
        <location>
            <begin position="32"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP first transmembrane" evidence="4">
        <location>
            <begin position="299"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP second transmembrane" evidence="3">
        <location>
            <begin position="477"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP C-terminal nuclease-like" evidence="5">
        <location>
            <begin position="704"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2174116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="975" mass="109834" checksum="324D824E28341B7C" modified="2022-01-19" version="1">MPSNQSKQHPYAVSSTEKAEEKAVAITKIPAKFISYSHTAFAYCAFFMALGVGCYTHYEKIVRNEFYGYPDEWFPSVSATTGDRYPARAIFQIFIALTSGPRFALVFLWYWMTTRSTQTSSKGFGNFLLGVGLVRTVSCGGWVYITSSDDHLTHDIAMVLYLLCTLPWQLGVLYTSDKQNQAAIRWRRFFTFAFFTTLPPMIYYFIEHKVKRVPGAYTTYAFFEWSLILYDVAFDAVTALDFQNFELFVVDITNGSPFAHASTEEGSSKAATPKDAVSSSSLRFLSDVRGYLSDIYLAFVFWSMLTSLALLIWYFPLFNMGISGYEAFLIVTISPMFLGIKSLRRLIARYRGVAHFVSLAGVASYLLPDPPLRLATTALGISVSMMTWCATWIESNDRAGDLERNIVVWALGLLVHNVVKLTWWTENPIWPIMKRSIGGQNEVGLVLGIIACAEMVIRDGFSGQARVNSNKKFSPARGSSFAAAAGFGTLLFALHSMYSDSSTIMRWVVDGHPNAGPEPVPWGIATIAALAFGLVIYPFGNFVTGYVWYFVACGACAVFYNISGWTGYYAGLVLGAYLTSILPAIIGSLVQHPPFKTLLTATMIYNLLCLAHVWVVAYEFVPGGVYARERTNWILTAVMLMLGLGISNAQTSNSNDRRAQLNTTRATRRYTKMALLAILGLSGLASYSRMSLAKTPEPYRPNEKAFTAGIWTIHFALDNDMWASETRMRDVIRDLELDVVGLLESDTQRIIMGNRDWAQYIAEDLGYYVDFGPATMKHTWGCLMLSKFPIKNSSHHLLPSPDGELACAIHATLDVFGQDVDFIVSHNGQEENLLDRRLQTTELARIMRESTNPFVFLGYVVTKPHQEIYKILYEDGHINDIDTSDWDRWCQYIGYRQLARIGYARVSHGGITDTEIQTGKFKIVDHPQAYQVAQYNQMHESSVPHQLRYPQHFRGNGLREHRYHVLDNEPRYFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHM5</accession>
    <name>A0A8H7PHM5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Maintenance of mitochondrial morphology protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MMM1</name>
        <name evidence="12" type="ORF">INT43_004143</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MMM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHM5"/>
    <dbReference type="OrthoDB" id="5599157at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21671">
        <property type="entry name" value="SMP_Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03103">
        <property type="entry name" value="Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027537">
        <property type="entry name" value="Mmm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019411">
        <property type="entry name" value="MMM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF0">
        <property type="entry name" value="SMP-LTD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10296">
        <property type="entry name" value="MMM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="64"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="108"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2174123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="357" mass="40003" checksum="18AC01D5BD54FBEC" modified="2022-01-19" version="1">MSGQSNIYQEITTQLLSQIEKECSVCYTDVNTSGNLSAFVKGLLLGQLSVLIVIAIVLRYMFLEDTSQNKKQLSRLSPAAKSPASLKQIPSTTAHILNKTFYDILHHPPESTDWLNVLLAQAMSQYRDDAQLNDRLILAIDEVLNGGVRPGFFGPIHVTDLSLGEEFPIFSNARIRPSDDIGSMRAEIDFEFSDQLSLGVETQLMLNWPRVDFAALPVSLLLSVVRFSGTLTIELINPPESATANATPLDRYIAISSYSDFTLDFTVRSLLGSRTKLEDVPKLTDLITSKLRNVYVDRLVYPNFVKIKIPNMWEARDRKTREQQQVLDEKVEEAPASGISASARERMEEFVENIKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PI21</accession>
    <name>A0A8H7PI21_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MICOS complex subunit mic19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PI21"/>
    <dbReference type="OrthoDB" id="5544375at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012471">
        <property type="entry name" value="DUF1690"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07956">
        <property type="entry name" value="DUF1690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2174348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18516" checksum="77953B858A07F1CF" modified="2022-01-19" version="1">MGAQQSRPEGIIIYNENVPLQFSQNLVDSLESRAKRTKPTSTSGKPPLPHEVEGVVRERVAEELNRIREQQEEANNRLTAELSKKNLESKHNAVAINADIEDMIKRVQRPASKQLPAEISQKQQAVVECYRRNKTRPLDCWAEVESFKDAVAQAQKEFCINHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PID6</accession>
    <name>A0A8H7PID6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PID6"/>
    <dbReference type="OrthoDB" id="188035at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016833">
        <property type="entry name" value="Put_Na-Bile_cotransptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640:SF5">
        <property type="entry name" value="SODIUM_BILE ACID COTRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 10 MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13593">
        <property type="entry name" value="SBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026166">
        <property type="entry name" value="UCP026166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2174345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="425" mass="46396" checksum="02E50D94AD7FCC47" modified="2022-01-19" version="1">MVSLSTFELKTVPRRFGCSAKLTNNRFLMGLAIVIVLAWRFPGVAKKDGVIHSEWSIKWGAVIVIFLISGLSLRTRILAKTIMRVRLHFMIQVISLVIIPFTVYGVAVFFAAVKLPINHMLLLGLVIAGCTPTTVSSNVVMTKNAKGNEASALMNAALGNVLGIFVSPAMMTVFEKDTRISPSTSAHGSLDYVDVLKNLGLTILAPLVVGQIIQWLFPRQVAAVKEKCRLGDINSIALLALVWSVFSDAIASNSFAAVGAVDIVAVVIINAVFYTSFSMFCLLCSRLPLPRRVKTPEWVKNLRYSREDTVAVMYCGATKTVAMGVPLVSVLYQDAPAGIVGVLTTPLLLYHIEQLILGNIELHLLKAWVTRGEKKHEKEALIHADEEHGIGLHEIDGYDEHQQSESNIHPSTIAPPPVAISSEQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIU1</accession>
    <name>A0A8H7PIU1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_005774</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIU1"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF151">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="36"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2174716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="512" mass="55900" checksum="8F215DCF8E40811A" modified="2022-01-19" version="1">MSPESNATTTATTRQPRADVREPPYSIFDRSQKWFIVMMVSTAATFSGFASNIYFPALPTIANDLGVSIELINLTVTSYLIFQGLAPSLWGPISDVKGRRIAYIGTFLVFLAACIGLAETKNYATLIVLRCLQSTGSASTIAIGSGVIGDITTRAERGGFMGVFQAGLLVPVAAGPVIGGAIAGSLGWKAIFWFLTIYSGVFLCFLILLLPESLRAIVANGSRTPKNILTRYPLRGYQKTSKVQYNQDQNDKFDPAEKRRIDLLAPLRILMSKRAAPIIIFLAVYYAVWQMSITAMSSLFESRYGLTETQIGLTFIANGVGSMIGTLVTGKILDADYRHVKTKYEATLDREKGNIVSKASQEEDFPLETARLRLVPFFSILQCLSIILFGWSIQYQQKVHIAVPIVSTFITGWTAVSTQSLIMTYLVDNFSDRTAAASASLNLARCLFAAGGTSFIMPMINGVGPGPAFTICVAIQLVALVGPLIQWKFAAKWRRIERDEEAARTPPRVIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJ24</accession>
    <name>A0A8H7PJ24_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_005840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJ24"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="219"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2174778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="987" mass="110533" checksum="4E24BF9331B90F39" modified="2022-01-19" version="1">MFSAEGMAMAESFLDDMDPTMQFMTAGGQQTQSMAEFEAHLQAAMLRNQQQNMLPSTKYNNMDSYMNSSDLFEFDEFSNFNIPIQQKQPEPALPLPNHQIPLNFDIKQEYASPASSYDTETEPRQSTSLSPIDQAATLMSIPSLSIPQSSPLASAPAGAMASVPPPASTMSLPSQQPTATMMPFEDVASFPAVASATMTAEPTSINASAASTPNGEKPEKKVAHNAIERRYRNNINDRIAELKSVVPALVHAKVKSGSKRNNNEEDDDDEDDNEILDGVAVATKLNKATILRKATEYIVHLKNSNQQVRDDNAALRQIIIQLPGGQEHLMRYQLHAQYKAVQENNRIALEKAQQKQDILNATNNRRKRRRTYERRSQDDSDSSGPVTPPNSNTGRIFMAAFMAVSLFATSPLTTGSVQRNVDDHHHVSKTATANLTDKTVEMTLFGFMATNTWQWIRTIILVVGITYLCLPILFKSSRSSKKHVARQTNRSNVINFQISQRNTQVEMYKALVSSLSTPPPNPASVFQGVIALTLEGFRFLIRRLSGHDIFYDGDKDQDLEWTRACTWLRMSELECVGRSPLITRISMLHSCLKTINLAETLETGRFRSYSRLYATAAVQVALAAPQSVAYACSRYFWHLAFDYYDIDDDDQDWFQMFFSDLHQGDVEDSVVDLLHSDVWNESLNIMRLQTQLYHVDRIVPKIKPTSTVPLEIIANFHILRSLQPLYSQLVHLLTNPAPVDSEDDVSESGDTRFDEILAACVSSNNPTRWYALVGACIEAIWDNNLDVAQALIGAIKELPHDSNTEDQIIQRGIAYALIANTQLRRGDRDAAVRVLVKARSVQMERTNLIDEAEEEDFLSIENNIMILADFVTSILTLQAWIKILEPQQPMKVGDDVTLAVPEMNSIVLSLIKQLRRMVVAPPMVLDNYNQEVLDRLCRVSQIFYGISTQDSGCECSDDESHFDGVMDSKNFDPNPATQALQILHGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJ59</accession>
    <name>A0A8H7PJ59_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_005900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJ59"/>
    <dbReference type="OrthoDB" id="407832at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051961">
        <property type="entry name" value="Fungal_Metabolite_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563:SF2">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2174838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="35947" checksum="B41120B777A64FF3" modified="2022-01-19" version="1">MLNIVKTVTQHLPSIPIAIKVSPQEVASGSLNWKNLELATRSLHRDGLVVLEDVIEHAKLDRLNEKMVKDAVILQSAGDASPFNYNKGNIQQDPPLTAEYFEPSIFLNAIATQVTSSMMGPRPRLTFVSGNTALPPTADCPPQSQPTHSDADFDHPSCPFAFVVNVPLVEMTPDNGSTEVWLGTHVFDHNYQEGKHGDRASGRVVESLLEQRREERPPSQPTVKKGSLVIRDLRLWHGGKPNFSNQIRVMLASIYFAPWYRNAMHIDYSEALKETINKYGCGLQIQAEFKPEEEIIKGYLNRPFGNAYDFNQQDRQENEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJ62</accession>
    <name>A0A8H7PJ62_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_005773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJ62"/>
    <dbReference type="OrthoDB" id="2340369at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2174715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="106" mass="12277" checksum="8F51A7D43761013D" modified="2022-01-19" version="1">MQYDFSYILLSDMPSYTFESPENFRDSYEDMAKHIDSQQEITGEWADGGPSFKYNLSTIVFDDCVYDLDRDFDALYSTLHGSRTKPMVVNIKTSGKPVQFEYIPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJE5</accession>
    <name>A0A8H7PJE5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJE5"/>
    <dbReference type="OrthoDB" id="2283184at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2174855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="89" mass="9627" checksum="A73388EC2DDD74EE" modified="2022-01-19" version="1">MNPQRQAQEVNLQDSNHVELHAPASSQPRKSVSDSPIEGMPKGPDRVAALKKLGATFEEGNHKVAKIATPIEETPIPSFVDNDQINVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJJ2</accession>
    <name>A0A8H7PJJ2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_006080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2175018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJJ2"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2175018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="55765" checksum="D73D0415BEE4F28B" modified="2022-01-19" version="1">MDKGQSDGFVTPQSPNIPSGDKEKIRSSLCSLETANAPMMKDYSSQISNDYSMEDAIIDGSGFHKEIAKKYSAYSSWRKWCIGAIVSLAQSISPVSGLSFLLALNPMRESLQVSMTEMKLAMTLYMVVQSVTPSFWGPIADGYGRRPAFGATALPAVGSGVIGDIATPSKRGGYIGVFNFGATCATIFAPLIAGAISQVFGWRWIFGILGIISASVWLIILLFLNETLRTLVGNGSAYANSFPLQRLCLPKKSKIEPLSSEASNSKSKIAATSILFASFQNLREKDAILPLLYYAIHFASLCCFTTSIPELYLRVYSMNSVQIGLVYVVHGVGSAIGNILGGKLLNYDFQATAKKQGMSASSSFRGNLDPSFPIEYARLRCIWIHVILLAAAVGAHGWCIQKQASLFAVLPLDFIIGFASTTNYAAVQNLLLDIFPGRQASIMASNNLTRCLFGAAATQATTPLITFLGVGPMFTIIAGLELLSLAIFIPVLKWGPQWRKQRLERTENLSKTVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PK18</accession>
    <name>A0A8H7PK18_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_001114</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PK18"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase C-terminal" evidence="5">
        <location>
            <begin position="241"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2175467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="384" mass="44595" checksum="8C81CD4B8E76A73D" modified="2022-01-19" version="1">MPPSKWTPRLVVKAIFLALVMNVQTTLVWLAMVTCYSLRPFSLKWFYVYLAHLLELWAQHLVFLIQYFAPCDLVITVDESCTKWTKADGSSEDNGIEEVIRRKNNGTIETIAFPSRIAVMSNHQAMQMLDFIFLKRKLAEDQAIMVNNLERAKKTNIPMWLLLFPEGTVISNKTRKISKDYAEKMGYNDPKFVLLPRSTGLRICTNTLDNSVKYLYDFTVGYSGLKIGDVPEDVYTLRGILLFGHYPEKVHVHMRRFLIAEIPKGEEEYATWLRDRWTEKDALMAEFYRTGAFPGEDKRVPTKVNTERVLDDNTGEVKVVRTDQDSSIYRSLEMPIKLKHTILDLTQVWFCLLPYVPIVKVFWAGMQIAWILLHQKEYNDKSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKH8</accession>
    <name>A0A8H7PKH8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Superkiller protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_001359</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421075at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="395"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="429"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="572"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="606"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="904"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1312"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1114"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1324"/>
            <end position="1335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2175712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1368" mass="154794" checksum="EB7B19CF00DF2432" modified="2022-01-19" version="1">MNTKANLKNAREALGAKKYAEAVKFCNRVLDFESQNYNAYVFLGVAHNGLEQYDNAENDYKKAIEINPEQLLAWQGLVSFYEKREKWSDLAETLNKLNEIYALLETLYYYTPDSKYHALISDSEQMPDLCSIWLEILKIKSGQEQKQIDRETQARRMRMNAGTPAKIRAQVEAEVAAKSHLGSIFETVLKEAQTSDKVQADVQDLKAQYFNFLRKRIRSDKEKDEAYQKLHDLAKQLCDSNVDVPEPYEFLIESSNVESYDLYDKSLCDNFASQFPDHGLSKLIEGYKLYEAGEADEAFDLISDGMEMSPESLFGHQCLSWLYYNSGEYESGLEYATKGRDIALEHAKFYGATLDRVLLSMELCMAQCYRRLSRKYYTDAMALCKKILVSFKDNIATLECYGLMLSELDRQKEALEQFNAILQLEPTRSSAKVEIGWIYCKQGKYEEALQLIQDAIEASEEGIPEYYYRLGRVYWEMGDPYKSDKEYAYTHFIKAAKIDPHFSPAFTHLGHYYRLVEETVTKAMKCYQKALILDPSAVDAAYYLTEYYQESGDLDEAETILTDITSLLSRTGWAWRRLGFLQLKRGEYLKAIPSFQNALRSDSRDVPCWEGLAESYLKEGRYIAASKAFTRARQLAPKNIYTSYQSALVKQKIGSFEEAIEEYLQTLALAEDQNESPYIPALKGLADTYLLQGRDNFQQGFFGRAAECYNSVINACLVAIKHSSLESFWETVGRALCQYQSVLSYANLFAYDDIQELMILLAPSPNELLKFPSDSCAELVTDFSNLDITEDFALPRKECADVLLSCASFAYKQAIWLASQKGSHGKHYWHNLALVYYWYWQNNRTEPSSEDQLKMALRCMKLAIKADDDSPAFWNTLGVIALEHDAKISQHAFIRAMQLDTRSAVAWSNYGYLCLIQADFELAAQAFETAQAIDPEFTATWIGQAYVAQLWNNSPETLFEQAYGLSNGSSLKANYGYASTVFSQASKDTHAPNPTLLVPPAFALQKLTEQYPDNPAALNLYGLLLERLQQYEQAAEAFAGAVLAAEERMERDSSQDEVCQKHITMIHANLARALCASGDFEGAISSYNIAIECLEDHTTKVYCELGAGISYYFNDQLDEALSMFEQALSNAEGQNAELRQKLSVLLSQVLWALGGEEQRELAQQELFKSIEENPNHLPSIFGLCAMGLIQDNDTLTEAAIQEMLKLPIGQEGFEDHDGLAAWLLSKYYEIKGSTDDAVRAISNFVHQTPNNASLWIAMASQMMGKRHYKAPYLTASIAVSTTGLSMLASSSTASAQDKSMAYYNYAQSLLKQQEDSKSRKRKAKDGPPPDHRQEIQEAAQRAVMLAPWDTKAWTLLGIAKSSMKVIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKJ6</accession>
    <name>A0A8H7PKJ6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone reductase complex 1 MLRQ subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKJ6"/>
    <dbReference type="OrthoDB" id="5511684at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010530">
        <property type="entry name" value="B12D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14256:SF1">
        <property type="entry name" value="GEO09626P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14256">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE MLRQ SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06522">
        <property type="entry name" value="B12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9891" checksum="0ECBAC8BC0EB11E7" modified="2022-01-19" version="1">MSAQHAAKKTLWQIWFKPEIVPIYAVVGGAVGLAGWYLNRLAHGTEVVWARKSNPYPWQNVDQDTQVKWMTVNQKFDKTYSRDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKV3</accession>
    <name>A0A8H7PKV3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleolar protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_001207</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKV3"/>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000001">
        <property type="entry name" value="Ribosomal RNA methyltransferase Nop2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023273">
        <property type="entry name" value="RCMT_NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02012">
        <property type="entry name" value="RCMTNOP2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="287"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="582"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="86"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="504"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="379"/>
            <end position="385"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2175560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="664" mass="74430" checksum="F5E6B4FA49845206" modified="2022-01-19" version="1">MGRRAKNKQGPPAPLPGTQESKGPSRRQLSKVRKQQRLQDSKKRSQDSDDDSQPQVKKIKTQAKQNGKKQVSASKQDESWDNASLDSDDELLDGDDEFPIGSDEEIDEDEEALEEASDEDDLDNDGVFPKVENDFLGSESEVEEDEEEAGDSDEDEDAMLDSDEDDIAEFAGLDERKSRKLEERAAREAAEAEAELRDSAMQTNIGEDGREFEEDEDEDQADISQINLRIKETVNILGNFKEMRDPSKSRQDYLDRLLKDIATYYGYSDFLAEKLFNLFSPAEAIEFFEANEVPRPVTIRTNTLRTRRRDLAQALINRGVNLEPIGKWTKVGLQVFESQVPIGATPEYLAGHYMLQAASSFLPVMALAPQEHERVLDMASAPGGKTTHIAALLKNTGMVFANDFSKDRLKSLTANITRLGAKNTVVCNYDGREFPKVIGGFDRVLLDAPCSGTGVISKDPGVKVNKTEKDFIDIPHLQKQLILCAIDSVDANSKTGGYIVYSTCSVTVDENEAVVDYALRKRPNIKLVSTGIEFGREGFVSYRGKTFHPSLNLTRRYYPHMHNMDGFYVAKFKKFSNKIPKAEKNGKGAEGQEADDENSNGPTTFLEDEDQNIMQGLYIFQYGQMLHFSLVHLTNNCGDFLHSEIFFNRIHAKASKESQTQEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMV3</accession>
    <name>A0A8H7PMV3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_005563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMV3"/>
    <dbReference type="OrthoDB" id="2427267at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="508"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="420"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2176329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="612" mass="68286" checksum="48A1583B451C045A" modified="2022-01-19" version="1">MAADRFGSFSSINKHNSSGNWYQNPVNDTKHKNVDKELQRIRGLGVVSVRKRYEDVSSISSASSISNRASDSSNEFKYIKNKLSKDSQLSVDEPTAQHLSKEIANNTTGQADKLAVQTKQLRSNTDSQLPSANSDASITMSPRSYISESPTTTIKENKEEEAKAEMEDQTQNIPESHNLEQKQPSTGSEEDALNHIEEEEKSPAAAASDSVESIIGQAQPDRPMTDNEETSSRVDDKSPTVDQEEDELMFTPNEIPSTELSWNNEVPELRNTDTDKEIDIQQAVKPSEETAIESTLIQSEPHTADKHNSIANIVSEMHILAEKAKEISNEQDQELAEKLRIRDQMLKVVESLHVPDDAVNNCNDEAALQSELADLRRQVQELNLKCELQQVDLQERAAYHSKLKTEKEALVRKVSIMAAENTSESDSISKNLNRMSTGSTFSSFSQKTNGVPASRPSSRRLNSRPESPIPPQLPPPRDPLPPIPKDQQLPSISLKDTANRYSGVQIQTDHHERIVQDLLSKLREAQEEQTRSKAVIESLEIKLRKTQIKNLELEKSVRALGSERHELLSKQRASAPPPPLASPPQSSSPSTKDKKKRSRRSFGNLLSIFSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNE8</accession>
    <name>A0A8H7PNE8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_007534</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNE8"/>
    <dbReference type="OrthoDB" id="10266508at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="89"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="684"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="420"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="565"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="640"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="810"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="450"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="587"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="640"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="810"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="835"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2176880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="872" mass="94701" checksum="D57501E7DA6684D2" modified="2022-01-19" version="1">MAAISLPSNPSEDFTPSTPPASNDCIGILGVLHDQPISSQDAHHIIKLLDSVKLRAGRELERIREGERLLSMKDAAKQDAESKIKFLADMSHEIRTPMNAVIALTDLLLQERDTLGDEQVEHLEVIQTSGHHLLTVINDILDISKLNHDPKLKLEKRKFSLRKCLKDTLNMARHQATTNLHNKVVHLIECPPDMEDSSSLKQILARVEKGSATPPLPRVMKGKTLLPLVWKIERDVPDILIGDSMRLTQIVLNLCSNAVKFTKQGHIEVNIKRYVPNAAQSQSTLPSNSGKPMYEAKIENIRSRAVRESTAQKAKQAAVTSNTNPTQEGYDPNAAETVILEISVSDTGIGIPSDRLPKLFKSFSQIDISTARRYGGTGLGLAISSTLVNHMGGGLWVESEEGLGSRFALTIPILVAPYQPDTPGNRSSDGWTPLTSPPSPCSTSSEGTSGAQSVSTERSLDFTSPATGCLSPSQNISHAQGYFSQHSSTRSTSPVAQPAPQGNTYKQPSIPSLAWAPPPPPVSLALGAPPIAKHPYSSNQDGTPTNKPMVTRSQYANADHDSLAIPASGSASVSPKVKPQTIDTRHNSTGSSNDSQHQQPLPSPPRIIVGKSQTLTTKPADDKQAGESSVPKVNASLLTSAATSGGQSVSQNRTSRASVAKQHHHHRRGGNVNEENVALAFPVKILLAEDNVLNQKIAISILKRLGYTGVEIANNGREVLDAMRRTRFDVIFMDLYMPEMDGLEVTKSIISARHSPDTDLHNVHDVYIIALTASASMQDRQICIEAGMNDFISKPFTMLEMKTSLKKCMYRQRKKRRKQQSPRPEAPNSGKQSDGEEGEDEDEDDDDTTASANDPMLGVEGASYQGLVRGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNJ7</accession>
    <name>A0A8H7PNJ7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_007609</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNJ7"/>
    <dbReference type="OrthoDB" id="409586at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="12"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="109"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="209"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2176955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="32590" checksum="B8A95FA633E26959" modified="2022-01-19" version="1">MTGLIIILIRSNQAIKDCLSGTFGGILQVLFGQPFDTVKVRLQTQSRTNPLYSGMLDCVRKTRAKEGFAGFYKGTTTPLVGIGACVSIQFVVLEYMKRTMSQKNPDLPLSNAQLCLAGGMAGVANSVVSGPVEHIRIRLQAQTGAGFSGPIDAISQIYRSYGIKGIYKGQMMTVLREGVGYSAYFAAYEWLVQRTMETQHVSRKEIPTTQICLYGALGGYAMWGMMYPLDVIKSKLQTDNLDVSKRQYRSALDCARQVMATEGPKGFFRGFGPCMLRAAPVNAVTFLGFETAMRFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPT6</accession>
    <name>A0A8H7PPT6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPT6"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="16"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2177948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="309" mass="35103" checksum="DB06AAE797474AE1" modified="2022-01-19" version="1">MDIDSCIETVKTCKYLPESDMRQLCNKLKEILTEESTVVPVQAPVTICGDIHGQFYDLLKLFEVGGEAPDTSYIFMGDFVDRGRFSLETLTLLLLLKVRYPDRITLTRGNHESRNVTRVYGFYDECLTKYQNAKVWEWCCTVFDYLPLAALIDGSIFCVHGGLSPELSSIDSIRTLFRMQELPQSGGPCDLLWSDPESQVETWAVSPRGGGYLFGSMPTNAFCHNNEVDLIVRSHQLVDEGFNYPFPDRRLVTLWSAPNYCYRCGNKAAILGIKENQSEVEDSDYRIFLENEYQGDATHANRPGNAYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQ79</accession>
    <name>A0A8H7PQ79_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQ79"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039588">
        <property type="entry name" value="FBXO4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16008">
        <property type="entry name" value="F-BOX ONLY PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16008:SF4">
        <property type="entry name" value="F-BOX ONLY PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25499">
        <property type="entry name" value="Beta-prop_pof12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="20"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="482" mass="54985" checksum="CDEC2B708D05DEC1" modified="2022-01-19" version="1">MSKPAVKRRRLAAQRYENRRQDLLTLPQEVVFHVFSFLEAADLTTCARVSTKWYEAANDDHLWKPLYLVRFSNPRQLLVQQLRSQRLHSKLATGSHTAGLSTAATHNIDQRLNDRRNKWKNLYKVNHNWETGNCQVDELALPLKEERLPIDQTSNETIIQICHDMMATTWGGSSYIDIWQIHGSHIEHISKAGPSTPTCTYVTCIKWDTVDTRRVIVGYSNGGFTVYQVDARERFVQQLAHYEARPSVTCDRHCVKSITLCDNVVMTCSTDMELSTYTFDEQGNTRFCHCLTSAMHWEPLTIEVYSKGDQTYQAVVCFGMSVGLDSWTIGLQEIIFTANLILNSRHSSSRLPPGHGLLDRIQKISYAHPYVVTSHKNNTMQQYRIITEHGKRIEIEHVRTLWGHTNSVGAMAMDARIGRLVSGDRAGIKVWNLESPRELVVGIESGFGERMEWIGFDSEKIVTVAGDHENNVKVWSFTSSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRK2</accession>
    <name>A0A8H7PRK2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_001814</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRK2"/>
    <dbReference type="OrthoDB" id="2399539at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="388"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2178967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="661" mass="76279" checksum="A975B9C37EDFBF1C" modified="2022-01-19" version="1">MPQLLQIHEDSLSKFRINSADESFLNFKGNRQHSTYQFMGARKFTGSTTALDVNKSTVGIDRMDTNNLDQSHIRSATSQGQLAERRLPRTRQSAGYTCDRCLSKGAECRYSGRMRMYDKHRSEAQVQKLHKELSKISRTLDAMEPQLDKKSNSRATPNDTLALQTKSSDILSIQELVHIAGWNLIEGYDDSMTIETNIRLLDDLRSTLLELLKTMYSRAGQPLRSFSSNPIIPSSFSNVSANLKQKKSALHNRNMVVFDQLNRYASIIPMEDDVNNNMDVLDLKTMQEILITYADCGFPLMASSRLTAETCNMLMSSENRALKASVYCTSVFHGMKFHKHAHFNRDEIAKVLFPTAYELDLGEPNIAMIWQLLHLVSHDLDYGKIQKAYLNIGVLARICFALDLHRPCGYLKYEDIWSKEQAKRVFWCVWLFDTLVPQFFGLPDLMNPEEIKIDVPLIIDGMDRHDKERTEFFQQIINSRMVSRKITQTITGISSNDEAHLLSTFTNMEQVIREHYNGLPAWITQDIGLRDNSDTLWRRRTKYCTLIEACTNWICLYQSYLPPESSNGSLSHLEKLALNRCIESAKTLQDLFISWLSMTSKETDCMFRPYLYHYMTTIGIYKYLAVSSHVEAEIRHFSRLSLVRFLELYRQTPLYHARQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRV5</accession>
    <name>A0A8H7PRV5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycosylphosphatidylinositol anchor biosynthesis protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_001982</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRV5"/>
    <dbReference type="OrthoDB" id="17366at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009580">
        <property type="entry name" value="GPI_biosynthesis_protein_Pig-F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06699">
        <property type="entry name" value="PIG-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2179132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="14728" checksum="9B247A04C6425829" modified="2022-01-19" version="1">MVVSAIIHIVAVLLGAPFLDKLWSTACFSVLVATVVCLPVTNQLGIADSEIYTRVFMKHRPITNSEMAAYIQAVSVLVGAWLGAVVIPLDWERPWQQWPISCVLGAIVGQAIGSVSTAVLYFMPTTLENDDRKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRY3</accession>
    <name>A0A8H7PRY3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRY3"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="2"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="222" mass="24330" checksum="9D72E4371A3DD7D5" modified="2022-01-19" version="1">MSTLPQGWDARQAPDGRWYFIDLRNNTTTWDDPRTNPSYNMPSPSASVASPPAYPESRAPYGGSPAPAPYPQDRKGPPSYQGSPYGQPAQSPYQQGGQGQMPPAYPYQQQSSPPPPPQQSGYYSPSPYDQPPQQQSPYQQSPYQQQQYQQQYQEPYPPQQGQSPYPPQQGQPPQQQQGGSGINKFLQGPNSGMKVAGVAAAGILGGFLLGEVAEHHHDTGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PS61</accession>
    <name>A0A8H7PS61_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_001631</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PS61"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043456">
        <property type="term" value="P:regulation of pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517:SF1">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2178785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="24934" checksum="06907BD45C809DB2" modified="2022-01-19" version="1">MRITLVRHGNTDANKQRWLQGQMDTHLNETGRRQAELVGKRLAEESFDMMYCSDLSRCKETLAGITEYHKDTPVTFDKRLRERDFGKLNGQPYKTISHNARHLTITDEQLIIEQGGESELDMELRVKQAYQDLTKASLEAGHEHILMVSHGGPLAAITVYITEELDYQWPVDCITGNKMSNTSVTTLRMTGCSGQIETFNCVDHLQSMLDTSLSSDLGPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSJ6</accession>
    <name>A0A8H7PSJ6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSJ6"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000093">
        <property type="entry name" value="NLI interacting factor-like phosphatase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="193"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="382" mass="41774" checksum="6101C66A44AFB764" modified="2022-01-19" version="1">MSNSQEAEQSVPPLEQISKPENPTSSSTSNTLSNPAQVAPEELITSSQPPANFSETLHPRNPTTDAVNPPSPSTSTASSVTSKKRKKAKRSNNFLSLLLCCSFGSGSLLDDKDGSRGGDVSASEPQSERVLDRPTHRADSLNTTSASQTQPVSNLDELTPSTQHEGTSSIENPIALRPITNNSMALLPPVTEEYENKKCLVLDLDETLIHSSFKFISNPDYIVPVEIENQYHNVYVLKRPGVDEFLRRMGELYEIVVFTASVAKLLFKYADPVLDILDIHKVINHRLCRDACYNHKGTYVKDLSQLGRNLASTMILDNSPASYIFHTSNAVPVSTWFNDPHDTELTDLIGFLTDLTVIDDVTKVLDTVISSSNNAGPSTLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSQ8</accession>
    <name>A0A8H7PSQ8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_002038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSQ8"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08252">
        <property type="entry name" value="AL_MDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014182">
        <property type="entry name" value="ADH_Zn_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051603">
        <property type="entry name" value="Zinc-ADH_QOR/CCCR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02817">
        <property type="entry name" value="adh_fam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154:SF1">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="10"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2179188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="340" mass="36933" checksum="B5CF12EE7641A8EB" modified="2022-01-19" version="1" fragment="single">IKAIGFETPGDVSVLKNVQIHDPSPESQDVKIRVMAVSVNPVDTKLRQGAFGPPQNPPMVLGYDASGVVEAVGNKVQRFKVGDQVMMSGSHVRQGTNAEFVIVDERLVGRKPETMSHRETAALPLVGLTAWEALVEKMGIPESKTPVDKTLLIINGAGGVGSFASQLARHVLGFKTVISTASRPETIEWCKTQGATHTINHRKPLKEQIDALGATVDYALICYDTNKYLGELCEIVQPLGQITSIVEVDSNMPLQGGMLKAISFHWEFMFSKPMHNVDLLSQGLALDKIAQFVDSGKLKRLDTKVYDNLTLENLKAAHEALESGKAIGKIVLEVGKGSWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTI5</accession>
    <name>A0A8H7PTI5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transaminase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_003819</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTI5"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000066">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="49"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2180032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="452" mass="50330" checksum="A02910B805A1A525" modified="2022-01-19" version="1">MSAPSSRLNQLNSHMQPTQNVSFFQEIPQAAPDAIFHLTAQYKADTDPRKINVGVGAYRDDSLKPYILPVVKKADAILFNDETLDHEYQPIAGQKSYTTAAAKLILGADSPAFVEDRVVAVQTISGTGANHTAAAFLKKYHKQGAICLLSKPTWANHKAIFNNVGIEVAEYPYWKPSTRGLDLEGMLGALEKAPEQSIVLLHACAHNPTGVDPTKEQWQQIADVMDKKKHFPFFDCAYQGFASGSLDQDAWAVRYFVQRGFEMFICQSFAKNFGLYGMYGIPEIGSWTGMINLTTGLSCLFLGERAGNLTVVTRTAQQAQHVLSQLEILQRSEISNPPAYGSRIVDLVLNDKALYTEWTENLKTMSGRIIEMRERLFEKLKQLETPGTWNHIVDQIGMFSFTGLTAPQVKVLKEKYHIYMTENGRISMAGLSSKNVDYFAEAINDVVRNVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTV8</accession>
    <name>A0A8H7PTV8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003798</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTV8"/>
    <dbReference type="OrthoDB" id="9922773at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF160">
        <property type="entry name" value="ERAD-ASSOCIATED E3 UBIQUITIN-PROTEIN LIGASE COMPONENT HRD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="420"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2180011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="469" mass="51670" checksum="70B1FF5C1885E428" modified="2022-01-19" version="1" fragment="single">GQTIPPFLGLSQQQSSLLVALYAQIDPEFAPQVPTMLPVAAQQLALEYEKKNSVGKKLERADMTWSDEYELLTKLQQEAVERLSTADMDVSKAAANLNLGDDATMQDLLLASFLYGGVRQEIIDQNDRKNMSPLASPNFKGAKELLERAFSKKFSMAAVQVGSLYVQEDKLAAGANCTEGEDPKKLAYEWYLKAANLGNPMAQHKIGFYTEKGYGCEKDAKAALGWYEKACAEGFPDSAHNLAILYQAVEPAVGVEKDLKKAVEYFEKAKQWGYAPSANALGRMYLLMSKNVSIAKEAGIDGDDEKEFIVTGISLLEESANGGDADAMTLLGMIFGSKEYGLYDLDKSQSFFELALVRGDLEAYNYLVRILRAKMAAKAALEKQNMENFDKMDPANQQKLIQELAKDASAESITLAACSNPACDKKESTKGEYLRCSACKKSSYCSRECQKDHWKNGHKAVCSLNKKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTY2</accession>
    <name>A0A8H7PTY2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTY2"/>
    <dbReference type="OrthoDB" id="2408865at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2180282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="297" mass="33271" checksum="A6DFB2C052E2053D" modified="2022-01-19" version="1">MTGLNAETQTVINSDFSTPSLSTQLSVSHKNWFQDKLQPYASEIVFVWNSILLFEDPVLTSSLLALLGIYLGLIVYFSLPPISVLAIVGGTIYLGQETNGFGLINFVQHRMAIAAAQRPRRDFSQICEILDTFVDEITSLKQSLSELKQKQPILVNQLFSTERHVTGILITPATYEWGISNHMNGDNRTVIDKLNTWCTKPNFGCKSWVKITEVGMYLHKIIAKSARCRAFLIKCIALVDDAEWEKDFSSIPETDDEIPVLVVPKGNNEQNKITEDSSRSNVDDIATLIKQLTEDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PU42</accession>
    <name>A0A8H7PU42_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pescadillo homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Nucleolar protein 7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NOP7</name>
        <name evidence="7" type="ORF">INT43_003919</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pescadillo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PU42"/>
    <dbReference type="OrthoDB" id="10264910at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17709">
        <property type="entry name" value="BRCT_pescadillo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000002">
        <property type="entry name" value="Pescadillo homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03028">
        <property type="entry name" value="Pescadillo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BRCT" evidence="6">
        <location>
            <begin position="372"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="488"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="560"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="612"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="489"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="567"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="613"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2180131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="641" mass="72643" checksum="D97E7A7716A79E59" modified="2022-01-19" version="1">MAKIHKKGKSGAAINYVTRNQALKKLQVSLADFRRLCILKGIYPRDPRNKKKANKGSTAPTTFYYHKDIQYLLHEPVLHKFREYKAFAKKLAKVMAKGQYSTAKSLEENNKPVYTLDHIVKERYPTFVDALRDLDDALSMLFLFATMPVTEKISREVVEDCQRLTAEFQIYIMKSRSLRKVFFSIKGIYYQAEIKGQTITWIVPYQFAQAVPTDVDFRVMLTFLEFYRTLVGFINFRLFSEINVVYPPKLDLIKYEGAAGFNALILEAMHRQAPGSEKEVEAEVAETQKEVSAEDAARMKASEQRLKTLGSKLAELQGSADTDRPDEVMEEETEEAALDEFKAAAPTNAEVDGDDSMVTLSQIHAASTEVQKLQNLFSRCVVYLSRETPRYALEFIIRSFGGQVSWDETVSSDAPFPENDERITHQICDRPKQGHRFLSRTYVQPQWIADSINSHNLAISDNYAPGAMLPPHLSPFVEAKEGDYVPSAEVEEVEEEFEGETEDINPDDVDDLDEEEVDSADEDEEDEEVTAAAPKKVKTDEHEAELQAEAAGIAFSEYEKEAAPKKTTSKKTAAGKKRTAKEIEEEEAKELASIMMSNKQKKLYTKIKYSQNKKSEEVAKLEKKKQDLAKAKSGANKRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUJ2</accession>
    <name>A0A8H7PUJ2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUJ2"/>
    <dbReference type="OrthoDB" id="2367685at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2180118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="215" mass="22295" checksum="11BBD09999C5B6D3" modified="2022-01-19" version="1">MGLFSKHKLSSNGGNPPPYSSGASPQPQYAPPPPQNSGNPDSRQLPPGWITQQDPSSGRWFYVYTPTAHRQWEHPIDNPIPEQQRGQAGAYQGSPAGYQQPYGQQPYYSSQPQYVQQPQNSKFGGLGGGLGGLGGGLGGLGGGRMGGGMGMGMPLAAGMLGGGALGLMAGEAFDHDDHNTYVENNYYDDNGGNYGNNDFGGGGDFGGGDFGGGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVB3</accession>
    <name>A0A8H7PVB3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_003667</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVB3"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="10"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2179881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="221" mass="23360" checksum="92C63C861D541004" modified="2022-01-19" version="1" fragment="single">PEVVRSLNPKVETKAIVTHHYDPDQEDELSLMKGEYVVILERDADDGWWKGRNERGEIGVFPSNFVKEISDETPPPPPSRTSRGMSATSESVKSPGIGAAHSPLARPPSVPGGSRPSSYASNRASSISENAPRASPPPVSTSSRPSSVTENAGMASPPPLPNAKRPSSTADSGSINAPPLPTSPPPARGLSYISTASTRSHDTSSIERKDSKDDGFQSPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVI5</accession>
    <name>A0A8H7PVI5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S acidic ribosomal protein P1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_008659</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVI5"/>
    <dbReference type="OrthoDB" id="2194681at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="67"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2181077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="11148" checksum="1F95802164BF1CE7" modified="2022-01-19" version="1">MSAEFAIVYAALILQDDGIEITADKLSTLVKAAGVEVEPVWFSLYAKALAGQDLNALLMNIGSAGAAAGPAAGGAAAATGAADEPAAEEKEEEKEESDDDMGFGMFHEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVN5</accession>
    <name>A0A8H7PVN5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Actinin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003833</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-actinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVN5"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21215">
        <property type="entry name" value="CH_SpAIN1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21291">
        <property type="entry name" value="CH_SpAIN1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000097">
        <property type="entry name" value="Alpha-actinin, sarcomeric (F-actin cross linking protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000030">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000077">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="55"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="170"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="536"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2180046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="668" mass="76570" checksum="45EFC87328381F9E" modified="2022-01-19" version="1">MPRSFKSGSCQIHWVKVNPNAFFPLMSYRNSYQPSAASQQQVEDTAKIMDKTWETTQQKTFTKWVNNKLDAQSVPHIENLGEDIANGVRLIQLLEIIGDTPLGRYNKNPKMRIQKVENVNKALEFIKLRGVALTNIGAEDIVDTNEKLILGMIWTIILRFTIADINQEGLTAKEGLLLWCQRKTAPYDDVNVRDFSYSWTDGLAFCALIHRHRPDLLDYDSLDKSDRHGNTALAFDVAEKHIGIPKLLDVEDVCDIQKPDERSVMTYVAEYFHAFSNLDKVETAGRRVAKFAEVMASVWEMQNDYERRVKEASSLMAVIDGKQKDWKATQFSDSYPETKQRSADFTNYKNTDKRAWVTEKQDVDTLLGNIQTKLKTYDLAPYTPPAGLTLADLDKKWKILLESEANYHKSINAKIREIKEKLRKSYAQAANDFQKQLNGFSLELVKLDGDLDVSMLQLNRVQSITGELQPLQSSLQHLGELDRQCEEANTEENDYTIYSVEDLRFELSLVQKAVQKKSQFIENQIVSRNMTNLTPAQLEEFESTFRYFDKDNSNSLSPPELNAAIASLGFFYEDKEFDQIFSQIAEGQDEASFEQFIRYMVSVTEDKATPDQLCQSFRAIAGDKPYVTELDLKMCMVPVPVIEHLKRTMPKGEQDGYDYTSWVNSVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVR0</accession>
    <name>A0A8H7PVR0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVR0"/>
    <dbReference type="OrthoDB" id="2408916at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="434" mass="47261" checksum="249B2DD886ECA899" modified="2022-01-19" version="1">MDSQPQPQAGRFRRLLGGGGKNKANRLSLNTSTTFLSESLNKSSDAVNRRQSMQILPFTSSTVSSATSRSTKDTDSEFDPMSPSSDPTSQAEAPSVKLEGVPPAPQRNQSSRSFSSFSLGKKKSQSSFVHSPITPSPLELTQSPTSFDIEFMMVIPEHDTVTSNDDHLNVSNQKDSFKSIHNHTNSMTAQRLEGNKRSLSTNNLRSDSASGQPESANSSSSDKSSGLGGARKRLTALLPESWQSNDSRRARRSTLSSLSHNSDNETSASDSPPMTPANPNNQFVRDSEQDDNEYHLPHHLPITPLSTGWSSLVEDGEYFAEKKAPATAYAPLSLPTANQNGNSPATTHNVATPPPAPMPFFTRAQSSRSLKSSGQWGYDKPATWYLADQVRNVLGSALTEADMEIEQEWENHQELERQNSMTSTYHSRAVGGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PW65</accession>
    <name>A0A8H7PW65_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_008951</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PW65"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="30"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2181368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="386" mass="43923" checksum="66AF5D890F74E5B0" modified="2022-01-19" version="1">MNIVEENHHQPIDWSDFVASKLDTTIDGEYRLLEELGHGSYGCLFLGQNIQSSDYVAVKVLSKVGLDENQLALQRSEIDIQSSLSHPNIITLHRSIEDATHIYLIMELCDQGDLFDHVVQDSEINPVRDASFIRKAFSEILDAVQYLHDNHVYHRDFKLENILLKLTDNAEEELVTKVADFGLATRERMSMEFGCGSTTYLAPEHFLEDDQSDQDLEQPYDAAASDVWGLGVMFLALVFGRNPWQEASSYDQVFAEFMRNPAVLKQLFPISDDAYEFAKLALTIDPKRRPDIARIRQEFAKITRFSTLDIETPVLVSTPAMAIPRKQDCNVNSYDSGICVSGSWSDLADEPDTCDYDVDPFANDAMKYCDEDDTTMFAHDEESWWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYY9</accession>
    <name>A0A8H7PYY9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_006940</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYY9"/>
    <dbReference type="OrthoDB" id="268414at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2182014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="74" mass="9017" checksum="0592CD7B5C506CCF" modified="2022-01-19" version="1">MKATQKQMADARIPLEYRDYCAHLLIPLNKCRGETFYLPWKCENERHSYEKCQYEDYKRRMRALDKARLAEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZ15</accession>
    <name>A0A8H7PZ15_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZ15"/>
    <dbReference type="OrthoDB" id="10356293at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2182398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="346" mass="38321" checksum="85847FC602D4748A" modified="2022-01-19" version="1">MDSTTSAIIIAILVALLVSTIVYLTHLVRVIRQSRRQQSSTPSGLESTDISGQINVPDITIKDASEMDGLGVQKEAAKQKKDTDSSEGNNKEHLLSNLTDTSIVSDSPSTVSRENLVRVNEITDSANVSKLEALASASKLPQKIPPPCPYKGKIPCTCQQARGSMDLLRHHNNPSHTYPRTMQSTSSFSSGRHSTSAIDRVQYSDGKDKVHQWIAYSPSISQRNGKLPNHHEEDDDDQPIINHLNTGSKEDSIPLSNPRSRTRPSSPLSPHRTTTSSIVYPNQTFSDHHRLAAHQNINTFAYSPSWPNMPFYYAPAHLMAPNSPSHKSRVGHLARKSEDYYQQRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q084</accession>
    <name>A0A8H7Q084_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q084"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052981">
        <property type="entry name" value="Ingression_C2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052">
        <property type="entry name" value="CONSERVED SERINE PROLINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_2G01790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052:SF3">
        <property type="entry name" value="INGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2183513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="340" mass="36288" checksum="96F11B13C500C7CA" modified="2022-01-19" version="1">MTETYALNDDNTLHSLSPVAARGLAETGVFDLMDPFVGCYIVPSDKHRTKNHKDGGAQPQWNETLYLDVPAGENRLYVEIFDEDPRSSGVIGGVAVELSEINSAGRLDKWFPIRRSNGNQAGEVHLILNMEGSVGASMGSAPPSFAGQQYQTGPPLYTGSTSGYPQEKSPSYGQPPAYDGPATGYPAEKQYSALGPQVPMPLNYGAGSPPPFTPPPPQPYSAPGYPSDSPSSPYGGPPPSQASSSGYGSPYTPAVNSNSPYAGSASSNQAPEKQPGKPMPDWMKMGGAALAGAAAVGLGTWIADEVKDHNKPPHYKDNYNHTENKHNQHHHKHRDDSNWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0L1</accession>
    <name>A0A8H7Q0L1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_006330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0L1"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11372">
        <property type="entry name" value="RNase_PH_RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="6">
        <location>
            <begin position="12"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="142"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2183325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="228" mass="24903" checksum="6158311D4811986B" modified="2022-01-19" version="1">MKRSDGRTEPSQLRAFAASQSLLNRADGSAKFSFGESTVIASVVGPAEVKIRDEKMDEATVEVIVRPAVGFPSTKDKLLERALRQTVEPTILAGMMPRTLIQIVVQIVQEDGNMLSTAVNAISLAMLDAGLPMNSLAAAVSAIIDQEGNLLLDPNSKELENASSVHTFAFDNTTSYNLLLSHCIGTYSQEQYLDCLDACKHASERVHSFIRTAVEKRIEKEYQQLQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1C1</accession>
    <name>A0A8H7Q1C1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TRAF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_000513</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1C1"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRAF-type" evidence="6">
        <location>
            <begin position="108"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="4">
        <location>
            <begin position="108"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="438"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="407"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2184604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="674" mass="75827" checksum="1336B802A52B2E11" modified="2022-01-19" version="1">MLQMLLMGQYKCSVLKVSFNALRTIQALGLLGTNSCTIRILPDHIYCHDCIHDFLKKGNIDCPVCKVELDVNAFQVSKFVARQIGRLKIRCANHSTGCNYQGPISENHSATCSFQLEACPHQKHGCMEVLARKNLTLHVRSCEYELLPCPNNPKKCKPFLRQNKKHHDSTCKYFRCDYLEEGCHFIGTMVECRKHCDIYCGKLHARIADLESQVTALTKKVEAIDISPESDTGKKIVHERQNSIQDNHPPNQGWKRPRLANADLIDGEDMLEQLLQSDDYGFSVADDEHDESRTPGYPFSEDELMSLSNIYSDQNLNEDSHQSLINDIASTPHRDVSSPVSPHPNSPPVSRSREPKRKVQRYNKVARAARNQKTPQTQNAEDKTANNNDQTMAASTPGSERRSSTHSPPSNFMSPPSSGSMPSRKQRPMFVLASSYLNKHNSGSSTTSSPEMGHQSKSAQPLPWGQTPPEEPKVIGSFTSAMNEVEQPHEDCALLKSVNAFLKNDQYMFTTAGRYTCHCSMTGFFHCPNVADAQSTLGNCIKKGMGQVRPLPALIAKETPHLLLPVEAPRPYRAAIELFAHKMWSQFGVKVRPKRIDHISLAYFDETDGYQGWMEAVHNGLLTDMKEWARTSIPISGQTNWDVVLLRRTHKAVNQGEMHQFVELARWNNVDRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q289</accession>
    <name>A0A8H7Q289_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q289"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2185099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="122" mass="13467" checksum="E4F50B7C0B61E0BC" modified="2022-01-19" version="1">MEEEVEKAKSHAAAHTSQPQDSPLRQFIMTETNNAVRGQRSVESYVELVTALCKDEDQTFANQNIDLPRIIVDALWVLDTERELYADNSSGVDSGKIQQSLAQIVKETTASVNSPQSVSAMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2U8</accession>
    <name>A0A8H7Q2U8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_000835</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NAPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3 8"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2U8"/>
    <dbReference type="OrthoDB" id="193380at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.140.10">
        <property type="entry name" value="nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00570">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006406">
        <property type="entry name" value="Nic_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01514">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003704">
        <property type="entry name" value="PRK05321.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098:SF1">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase N-terminal" evidence="10">
        <location>
            <begin position="15"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="169"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2184922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="417" mass="47605" checksum="424853B35FB177F3" modified="2022-01-19" version="1">MNNHSQADIGLASILDNDLYKFSMQQVVFKNYRDSVVNYKFTNRSRSMKLNQQAVEWLTNKVKDMEKLTLSEEEYQYLSKLDFIGQDYLDYLKTFQFRPDEQVKFHLDPLTGDFELNVTGKWLETILYEVPLLALISESYFLYVDTDWNHDSQYENAYKKAEALLKEGCKFSEFGTRRRRDLQTQNTIMKAILDAQKGYVKSCEANGRKPQGAVSGSSNVYLAKKYNVTPIGTVAHEFFMGVSALEGIEHANKKALQHWLDVYKGALGIALTDTFRTEVFFRDFDRDLALAYSGVRQDSGDPLKFVDAMIKHYRKLDIDPKSKVIVFSDALDVAKAIQLQNYCTKAGVNSSFGIGTHFTNDFRKLSAPETKSEPMNMVIKLNVCNDKPVIKLSDDVLKNSGDTAFVNQIKDQLGLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q303</accession>
    <name>A0A8H7Q303_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor P</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_000287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the elongation factor P family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q303"/>
    <dbReference type="OrthoDB" id="7025426at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043043">
        <property type="term" value="P:peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000004">
        <property type="entry name" value="Elongation factor P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="ELONGATION FACTOR P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053:SF14">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR KOW-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation elongation factor P/YeiP central" evidence="3">
        <location>
            <begin position="96"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Elongation factor P C-terminal" evidence="2">
        <location>
            <begin position="170"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2184378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24465" checksum="97E3B090F33E6E03" modified="2022-01-19" version="1">MLKLAAARGRPFVLQSHKTAAIYHAHRDYKLAVGSIRKGQVVQHKDRPMKVINRDHVSTGRGGAVVKMDLQDILSGQKANERFKSSDSLEVLTLADETYQFLYSDAGKIHLLHGETYEEVELDESACDLGSKGISMLEDGMPIAVSFLTTPQAGTQPITFKLPAQYEYTVQSVIERAGQAAKGTVYKQATLTNGAKVQVPEFISEGEKIVVDINELKYVKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3C1</accession>
    <name>A0A8H7Q3C1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3C1"/>
    <dbReference type="OrthoDB" id="5563016at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF18">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="205" mass="23445" checksum="7B50D0570D942914" modified="2022-01-19" version="1">MDEDIIASDQVLTKKPSIEHMVVRRIKDTWTFNKVQKLVRSLSSKSSLPDLVHDSISPSSSDDSFWTDSDVTDHDMPMSVVWPSSMRSLPAPQPKIKGVLKSPESKSEPDLRRCANADHGMRQRHYSVIANKLTGRGKPHVHFRKNPYVHHTYSKSQYDRQTDQDAICLHLTVDVAGAIKNELNNYKMTEMAVHDQSRIYTHYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3N1</accession>
    <name>A0A8H7Q3N1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WRKY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002317</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3N1"/>
    <dbReference type="OrthoDB" id="2362414at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003657">
        <property type="entry name" value="WRKY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036576">
        <property type="entry name" value="WRKY_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03106">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00774">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118290">
        <property type="entry name" value="WRKY DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WRKY" evidence="7">
        <location>
            <begin position="257"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2185879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="324" mass="36667" checksum="6B042B279091092B" modified="2022-01-19" version="1">MNDLARYPQSNARDSGVYPRPIHPPHQQPQQSASTPSPLAPPQHRPLEPTPSSQMRYSTTSQPVRNNPPPPNNNGNNNNPASYDLQEIIVQYQQQPELLKLILSSKVEEDKRRAEEAKLRAKEIDLLLQQQPTPPNEMDVEEVTVKGRSSSDYSYAHPRAVPIRARMQSNDSVGPVRRGSILNSLDDRRSSFASQSSRYSPPGVAGAGLQRHPLSPPYSNPEDRDEDGQDANSQKKQRKRREMQAITKIVETREFPYLDDYFWKNNGNTTHKSGRRSVYYKCSNSGKGCPVNKTVTCRENGEYLIKYRGQHLADCGRVQRIHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q474</accession>
    <name>A0A8H7Q474_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRO domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_000275</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q474"/>
    <dbReference type="OrthoDB" id="2141925at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09242">
        <property type="entry name" value="BRO1_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF30">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="8">
        <location>
            <begin position="7"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="752"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="806"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="755"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="838"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="867"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="882"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="895"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="941"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="968"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="985"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1041"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1059"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1076"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1094"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1153"/>
            <end position="1162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2184366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1162" mass="128909" checksum="093335179BBAAC21" modified="2022-01-19" version="1">MASPQSPLISVPNKRTDEIDWVHPIKRYIAQVYQEDPEKYAEETNTINRLRQDMRGAGKDLTGRDLLYRYYGQLELLDLRFPVDEKHIKISFSWYDAFSGRLTSQYSLAFEKASTIFNIASTLSAIAAAQNRAEPEGRKRAFNFLQAAAGMYQYINDNFLHAPSADLGRDHVKVLVELTLAQAQECFIENSLREKKKDTLIAKLASHATWTYANCVDGITEGLTKSVFEKPWLTVCHVKQKYFQALSQYHKALACEAEGKYGECVGRLAIAESAAKEASKLANGLPANAATTTLPADAASALQENTKTFAATCSEKLKQATHDNDMIYSDTVPQESVIQPIDRLKAVKSVSISELYGANEINKVIGPDIFAKLIPLSVHESASLYSEEKAKVVRSETERCDLANGELDASLDYMKLPSALEKFRHQGERDDLSLDEFAAPTKEVRDWADRIRDEETTKSKVAELVDTLEALKDRAKSSLDKVSVTLDEEMRGCEQMRVKHGDRWTQAPSSSMTTSFRDDLRNHRLSFEQGNNSDRQILQLWDRVARDASILRQGSSSDDLARIFAESLAGIVGPEKKESASLLDIDIDSGVNKGSTQQKVKRVESVLEKLYQVRTERKDTLEDLKEKTHQDDISNLLILNKKSTNIEPQLFATELEKYRPHQQRIAQSIHQQQQLLKELTTAFKALMEGDDARKVQTQWDRAEKQRRTVVERFRHASEGYFEVKDGLLKGIQFYSNLNDTVETLSRNTQNFANDRAQERNDLSRDIEGSKSQMEQQLLKDKLSKYDNSSAPHDPSVYQLSDRTRQLDLNPGASAPQFSRPPVSPTMMRSPPALPPQPQAYANYPAPAPAPASSTAPHFADQHPSGPIQRSNSVTSNPGAGAAYGYQQSPASYQSGPPPPPPPPPQQQQLAGQADPYRSYSGGMQHAAPTSPVYHRPAASPMGPPVAPYQPAPPTPTGPPFRNDSIGQAPPPIPGNPPPPLPPQSAPYGPGSQDYRSQQPGSSQPYSPAQPARSGPYSSSSNYGTSYHSSPYGYNQPSQQPQQPPPQPGYAPKPQPPTPQQQQSYTPSHQQPPPVPGQMQYGYSPYGQQQQQQQLPPPPQPQGWNQPPPPGQWQHQPPPMPDQAPYHGHYQGSQPGPPPPQPYQQYWPPRNDAPGGGGNSLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4S2</accession>
    <name>A0A8H7Q4S2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_002540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4S2"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF193">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="6">
        <location>
            <begin position="172"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="5">
        <location>
            <begin position="705"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2186102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="914" mass="104466" checksum="A3EA06B80405B343" modified="2022-01-19" version="1">MSYCSWDQVRRQVRNTRASIQAQAPPSALSTIRDFRFDELHNRLFFLANEIVNPTTPGIGQMRLYAVDLGNVKSAPSMIDQPALPWIAVFSDLATDPELRNRSSYWDAGPPNPFRIHGIHSYQIAGTKVLLCSSGTALLGELDQAHTPASPTLRQYPPMNTDNHNSHNKKPQQDQSVRYDLKFGGQRGNYIAFIRSRDIWVADFYGNESQLTFCVDNGEDPTLMSGAVEFVMQEEFHRFSAYSWAPLTGSKLERILYLETSEKDVGICYIPKSTGLPLTSMTPAMREGEMEQFRYPRAGSQNAKSDICIVEFNSYVFRSPESIIRVKRMRHSYLKEIFPWMEYIVRFGWMPDGDSVWIQLLSRLQKRIALVRIPLCYFQEDNEHATTPLESATDPIEVMLEEHNNHWINISDIFHFIEYPKFKRHSRTTSQRIGEPTEFIWSSEKTGYRHLYLVKVYQSDDRSSMQPITSGDWCVLDRPITVDNERKLVYFMGKKETPMESHLYVASFAQEHLSENGTTIRRLTELGFSHNVVMDKSCQRFVDTYSNIQCASVNVIRYIEHNRTEPLPTVKLGAYSLQLSPASSEESEETISGANDYLKQYHDSPFVESAIPGPNLGECHARISSQDSISCDFEPLSPVVAGELPVGQIFNFVNSDGVVIYGCLYKPRNYIPGTRYPTLLSIYGGPKSQLVTNDYKFPRLMRQFMAVEFGFAVVIVDGRGSSDRGLEFEAHIYRRMGTVELQDQIEALDYVMREKIGAEPSSSGELVSIVDSDRVAINGWSYGGYLSLMGLAQYPDKFKLAIAGAPVTRWELYDSAYTERYLGHAHSNPEVYNQGSVLRRVRNFPDSPNRLLIVHGLIDENVHFQNSEELVTALKEHDKPHQFQVYPSERHGLRHASVNEHYETLMFFWLVNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4Z6</accession>
    <name>A0A8H7Q4Z6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4Z6"/>
    <dbReference type="OrthoDB" id="2387366at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2184786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="345" mass="38414" checksum="D799E526EFCF15DC" modified="2022-01-19" version="1">MLALIVRNILRVIQVIGALGTVICHSGEYTYLNQYLALLASDTSMDMTTEFTPEVPSVVWFLVSVVSIIVSLLVATLAFRRVSRIKSIERALAFFMVIIWGLSVGAVFALDEQFYSFDDVDSPDDTSEAVYLVEHHLVLYADLTRAMALVALSGWVLGLLFSLLSDCLSGHRHSHDPEKDQLNQWSTGTNSTTTTTEFSERYGPLQHHTARTPPSMVQTSSSYRNSTYKTPMEVANRASMAAHHEDMSSTHSWETNSHSSPRTPTIGITTPPLAFAKSEHPSSPLYDIPPSRGSYSYVYQDFPEIVTTPNHDELEEENVSPTSFAYLITNPKSPIPSLRRTKSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5J2</accession>
    <name>A0A8H7Q5J2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_002135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5J2"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF283">
        <property type="entry name" value="GLYOXYLATE_HYDROXYPYRUVATE REDUCTASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="3">
        <location>
            <begin position="26"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="4">
        <location>
            <begin position="116"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2185700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="338" mass="36686" checksum="CCF78898EF3320E8" modified="2022-01-19" version="1">MNRLRVLFCQQRFAPGKTWEALGSTILKNHHVKACSADQVEETLQSFKPHVLVPWWHPLPRSIIEKAPSSLGLVQQFGVGLDNVDVDACTDNGIWVARLASQSTGNADSVAEHAVLLMLALSRRLNASMNIVREGKPYGSLCGTSLMGKRVAVAGLGDIGVAVVKRLEGWGMDIVAVRKNVNADIPRGISPGTISRVYSLDELPQVVSSCDFTLCAIKYDRKENRHLFGTELFSKFNGSTFINIARGGLVDEAALYQALEDGSVGQAGLDVFEKEPLSVSSPLQTHPNVILTGHNAGVTDLFYKQGTKAFARNCDSFANGQLVQFGVNRPTNPRVQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6E3</accession>
    <name>A0A8H7Q6E3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease</fullName>
            <ecNumber evidence="9">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_002838</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="9"/>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6E3"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="10">
        <location>
            <begin position="123"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2186400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="352" mass="38865" checksum="2E44512B19A5D37C" modified="2022-01-19" version="1">MFIDSHKTRDKSRVFESRLRCIFVHTQNTNMVPPHANEQLVTDASTVASLEVASASNELTEISSTTTNNVSTSKAATEIAEHRGIKLIPPFPDSPPCNSLNLIDSYIYLPGIPDCIKEDLDQPCVLGVDEAGRGPVLGPMVYGVCYCPLSKYDDLKNLGFADSKTLKEEERDELFETLEKNADIARSSVHVLSPQTISTGMLRGQKYNLNEMAHEATMGLIRRVLDKGINITEIYVDTVGPPSSYQAKLSRMFPGIDITVAKKADSTYPIVSAASIVAKVTRDAILKKWKFIEPTLSESISQVFGSGYPSDPNTVRWLNENLDPVFGYPNVIRFSWSTTATILEKNGKAVIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6E7</accession>
    <name>A0A8H7Q6E7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ferrochelatase</fullName>
            <ecNumber evidence="12">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_002367</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="12"/>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6E7"/>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000003">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2185929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="347" mass="39066" checksum="5C68A3487C3F2E75" modified="2022-01-19" version="1">MGGPATLDKVHDFLHNLFSDSDLMRLPIQPLAAKFIARRRTPQIQDQYNQIGGGSPILHWTEKQGEMMEKILDQISPETAPHKHYVAFRYVDPLTADTVKQMKEDGIKRAVVFTQYPQYSCSTTGSSLNELYRCLKKSDPENDIKWSVIDRWNTHPGFVKAISQKIKAKLQEYPSAERDHVVLLFSAHSLPMSIVNRGDPYPAEVAATVDHVIRHLKVRNPHRLVWQSQVGPSAWLGPQTGDAIKKYGEMGKKNLLLVPIAFTSDHIETLFELDIEYGKEAHESGVTGYKRSESLNDDPTFVQAMADIVKGHLDAGQITSPLMALRCPACNNDKCAEQKEFFASQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q718</accession>
    <name>A0A8H7Q718_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q718"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF260">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2185926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="454" mass="51220" checksum="91A2265E0B3EAE2F" modified="2022-01-19" version="1">MDPGLPEKYPLPSWWLKNSKNPLGDYQSSPKLPNKTDILIIGAGYTGASTAHHLAKLVPSSCSITVIDARGVAEGATGRNGGHLIPYNHRNILRDVELFGVDYALWRRDLEWANVQEIVKFLKDSGIDKIAQIQKGDNVMAYCTQEAWQRAKEEVAFVKRHDREWGDCQVWEAEEARKQLKSPDVVGAIKIEAYQMFPAKWIWQVFTNLLKEGKIALYTNSPVTAITKYSSGAWKVQTEHRGSITAQKVIHCTNGWMGHLIPQIRDFCYPVSEQVMALKMPKPVWQNKGFVWHNVAHYIIQREKDNIVIVGGGRSTTDGSNRPFVDHDEVDFIGTNLGGMIRANDSSIYPVLHNDIRQFLRSHFPNEPWPEFEEAEWAGVQGYTKDHLPYIGPLETCPNQYISAGFNGHGMPLCWWAGRRIAEMAVGENQAVDDPADIFLPGTRMNIGNLNTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7B5</accession>
    <name>A0A8H7U7B5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCR4-NOT transcription complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_005156</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7B5"/>
    <dbReference type="OrthoDB" id="10265389at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019312">
        <property type="entry name" value="CNOT11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10155">
        <property type="entry name" value="CNOT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2173736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="347" mass="38734" checksum="D9FC744D1F83C922" modified="2022-01-19" version="1">MANAQAIERILSRLANATLADMASSFASSFLGQDTFTAACHLYMVYRDEERSPISKSLMDTLNDDQPERLMVQCILSGATQSIQSLSVVQLSKNLEQFIPISTVDTGRLHDLQLLEQQLVEPGVDNDSAGVAQTSAHHSTKHQQPDSMTVDPALMDAAFTSPLSIAQQETLLHMIESDPENLKNHLPLNHLPDLIEQNQAIAIEALNVLAETPEFSEYLQTILTIEVTSSTMEVVHRLLIGNHRKHIPDEFMHIYLSNCIRSCEVIEDRSLQSRQVRLVSVFVQSLIRNDVIKIADFLLEIQSFCIEFSRHRGATSLFQIVAEQANKHDFVLTSPTGETPSMDDTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U848</accession>
    <name>A0A8H7U848_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_000047</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U848"/>
    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF26">
        <property type="entry name" value="OS04G0435100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="544"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2172700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="583" mass="64014" checksum="FB33A00F0B1217B3" modified="2022-01-19" version="1">MEAVPTAAGQKLQHSERPMGMSGSNDSMTVLEAADPRNADELLLESLGYKQEMKRDISLVSTFAIAFGCCSILSGLTPLWGSAMTSGGSVAVIWGWITVSIFTFLVGLSLAEICSAYPVTGGLYIWVSRLAPKEWVPLMCWLTGWFNWLGLTVAITSADLGISQYIASIIAINNPDYNASVYWQYGIFLIILFAHGMINSMHIKYNGVFNQASLWWHIIGTFLIIVVALALTPNKPSAAWVFSFFENDTGFPDGYAFFIGLLQCQYTLSGYDSAAHMSEETKGASKGAPFGILLSIGTASIVGLAFLLSVNFCVQDFSRQIVNATISPEMTQVFLDGVGYNWTIVFVTIIMGAMFFSGSALTLGSSRMVFAFARDGAMPWSKYLYRLNKWTHAPVYAVWGNIIFAAIVGLLYIINDTAFSAIVSVNTIASSLAYLIPITLKFTVARKKFKRGPFHLGPFSSVINAISIVWIIFTSALFLCPTEAPVTPLNMNYAIVVLSFVIFLSLSYYLFSARQWFEGPKQTSVEEQEREREIATLSGDEKLKNNGYIQGVSSSSSSDVILDPADDQKYKGVQVESADEDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8J4</accession>
    <name>A0A8H7U8J4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8J4"/>
    <dbReference type="OrthoDB" id="10386303at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034536596" evidence="1">
        <location>
            <begin position="19"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="143" mass="16193" checksum="DA8FA7A1114B7793" modified="2022-01-19" version="1">MQYKLLAITALLSATAWAAPTVNSTDGDAPADVKAADNSTSADGVAAASYSRSIHLSVYDDKYFNGREQEWTNYDGYKFPCWKIDLDQVRSYKVNTDGVDVRFYEDEGCENMARAFEDSDWDHIWDDDVKKSKWVKVVRVWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8R9</accession>
    <name>A0A8H7U8R9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Polyadenylate-binding protein</fullName>
            <shortName evidence="10">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_005080</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Binds the poly(A) tail of mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8R9"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12380">
        <property type="entry name" value="RRM3_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1900.10:FF:000004">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000441">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000648">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000590">
        <property type="entry name" value="Polyadenylate-binding protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="63"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="151"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="244"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="347"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="13">
        <location>
            <begin position="569"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="475"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="492"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2173660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="663" mass="73210" checksum="FD1BB86EB18DE3A1" modified="2022-01-19" version="1" fragment="single">PEKNQQKNQQNLFKKKLQPFFIMSSPTSNPTPAEAVQQQQGNANNEQQQANFPPTAAGNTTSASLYVGELDPTVTEAMLFEMFNMIGPVASIRVCRDAVTRRSLGYAYVNFHNMVDGERALESLNYTLIKGKPCRIMWSQRDPALRKTGSGNIFIKNLDASIDNKALHDTFSAFGNILSCKVATDEEGQSKGYGFVHYETHEAAEAAIKHVNGMLLNDKKVYVGHHIPRKERQSKIDEIRANFTNIYVKNLDAEVSDEEFQEMFGKFGAITSAVIQRDEDGKSKGFGFVNFEEHEAAKVAVEELNDKEIKGKVLFVSRAQKKSEREDELKKQYEQAKLEKMSKYQGVNLYVKNIDDDIDDEKLRQEFSVYGVITSAKVMRDEKTGASKGFGFVCFSAPDEATKAVTEMNGRMIGSKPIYVALAQRKDVRRSQLEAQMAQRNQMRMQQAMPMPGAPGYMPGAPMFYAPPGGFMPQGQRPVFPQNGMVARPRWGPQGPQQGQQMPMPGYPQVPQGFAPNMQGRPQRGPRPPRGGGAPQSGRPQPAGQNAPGRKFGNQQRPNGTSGAQDAAPQALTAAALASAPPEMQKQMLGERLYPLIQQQQPEAAGKITGMLLEMQTSELLHLLEDNEALDAKITEAVSVLKEHTDEPAAESAETDAAEETKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U978</accession>
    <name>A0A8H7U978_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_009089</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U978"/>
    <dbReference type="OrthoDB" id="10056816at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="82"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2171428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="124" mass="13500" checksum="8CC8F93D6535B7AB" modified="2022-01-19" version="1">MSSSNVIGSLIFCPECGNLLDIPGGDDDLIVCNQCSYAQSSADYEAMEIVTTSSETAFQSPLKAKRHLVQQKAPTTEGSAMIDEKCPKCGNPEMAYHTMQLRSADEGQTVFYNCLKCGYVYHNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U990</accession>
    <name>A0A8H7U990_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_004418</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U990"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2174395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="343" mass="38880" checksum="BA1290A7C22CC484" modified="2022-01-19" version="1">MPRSNDSATTSTSSESFSRFEYQVAGHDRLLQHPATDIIVVKPCNKIEQRFYEDSQQHPEFLPWIPECYGSLHIATEDERQALTEAQAVEEENLLYGFVKPCVMDLKLGTQLYGPDATPAKRAKMILKAQQTTSAQMGMKISGLQMYDAATNQQILHTKEYIKQITEANILDSFLSFFFPSSCYAETLIAGRERVNALQKGLPIPSAKVRWIIQSLIDDIEDILQTVADMPDLRIYGASVLIIYEGDRSAVLDAWEKMLEEDRQQAEREQRRDVNLEIADDKSESEDEEAPSAKLYSIRMIDFAHSEWTSGQFSEQDDGILLGLKNAANMLRSLLSIQKKENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9C2</accession>
    <name>A0A8H7U9C2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_007798</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Fanconi anemia protein FANCD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9C2"/>
    <dbReference type="OrthoDB" id="27031at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029448">
        <property type="entry name" value="FANCD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32086">
        <property type="entry name" value="FANCONI ANEMIA GROUP D2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32086:SF0">
        <property type="entry name" value="FANCONI ANEMIA GROUP D2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14631">
        <property type="entry name" value="FancD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2177141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="203" mass="23076" checksum="53221DDABFABA631" modified="2022-01-19" version="1" fragment="single">PLLRKDTLPVFYQALATEVVKAHRNFKENQESDDMCILQLSQIIECFEAMANYIRSKDNRALLSVVLKSSRLFIEQMTKRTISYLSSRFKTHRSAVVSILKRFQIGTKTLQIVCSHVKIVRDIQLSSYVPALKKALEIVIYQAKALLTDNNAPANAFYLGALKHRDITGAEVSSQVSLSNKSSCHITIVLIYHVYRWKDTNGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9R0</accession>
    <name>A0A8H7U9R0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">B-related factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_001460</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9R0"/>
    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20553">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000002">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000007">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.650">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="86"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="181"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="327"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="572"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="597"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="632"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2171983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="647" mass="72252" checksum="D5F004731D61C07B" modified="2022-01-19" version="1">MPCVCGSVKTEADPTTGTTVCVSCGLVLEENSIVAEVTFGETAGGKAILQGSYVSADKGRLGTTGPYGRGRSNQEGREQALENGRRRTMHLAHALKLPERYQESAMRFYNLALTNNFTKGRRTEVVAAVCLYVVCRQEKSSQMLIDFSDLLQINVFVLGSVFLKFVQVLCLKNLPLVDPSIYISRFANGLDFGDYTSRVASDAIRLVQRMDRDWIRTGRRPAGICGACLLIAARMNGFRRTVREMIHVVKVADITITKRLQEFKTTPSGQLTVRDFRAVWLESEADPPAFSKARKRVKHTVEGKEETKEEILLAKQETALLEEAALKGSQLMLPPKKRKRQNEMERTTSSTANEGTDSAVSDENASVASENGEKSPLDAKQETMSTEDNELADELNTLMKDEALLKEAEKYEQSMDYKIDPGDADLASVDDDEIEAMLLNATEVEVKTKVWYEFNKDYLEEQRIKKEKEIMDRKNGVYKRAGPRRKGKANVGPAASAADAAKQLVTAKKISKKINHSIFNELFETEDSLTALKTRNNTPEPSAILATQKDSAYGGSQLAPTANNVDYSKFDIVEESNEAQTQPATPAKEKLETVGEANEEEDENEEEDEEHMAEDEKLMREARARMGWGDVNPDEEYFEDEDYDDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBF0</accession>
    <name>A0A8H7UBF0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_005158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBF0"/>
    <dbReference type="OrthoDB" id="191651at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2173738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="238" mass="26467" checksum="2E0FEA97BD27A625" modified="2022-01-19" version="1">MKLQKLWPSAEGRIHRSLQTCLSIGYPSKGTGANTSISIHENGKAHKEMVEKFLRDVYKRGKQANKDKEEVQKELQRIEQAAISSYNSRDAGAGPKMKLPPSAPSNKPSTLSKPATKPKSKPAPAPPPKQPTEPFEMPVPREMAAEAGPGEWTVVSKPVVREEKKDRSEKASTTHDLRPEMQDEFAADEEDLRHFKIQEKSFPEDSFVEAGTNNDEGGVVFKKRKLGGQGKARNIRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBH7</accession>
    <name>A0A8H7UBH7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_001124</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBH7"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000002">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041093">
        <property type="entry name" value="Dis3l2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17877">
        <property type="entry name" value="Dis3l2_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="3">
        <location>
            <begin position="659"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1134"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1134"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2175477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1256" mass="140153" checksum="6C9C3F3EE9D7C23C" modified="2022-01-19" version="1">MDTFHQTAPESTRGLFDLPEHATPARDASKRRSAQILSVNNTNTTTQDAQTSGKPPSKRPIRSHARSKSAITSDMFDNNALRNAQSASGLHTLVEEGSKTSKELKRQSTAANGHRSYKSGENLNPDESVAMSSLQDMINTLKSLPPIPPSNRLSTQNLEEPAARRGHRKQHSMSAINLHRNRFSQTIDQNNKAHHTSMQELRNIPEIPEQRTSKFLSGTQNTERKSDDEESGEYYSRGDALAEAEAKLMGTYKPKEEHVESTSTSLNDRRRSGRRYSDSNGSDRPSFSTVAASTFNKRTSLQLPTLSETSEMGANGKSKRLTFNKPLDLSLEKKSHRRSTSRNFDSDWRAGANSLAPPPTSASRSFNLVPFTPTKVNFARDDANPHQRRPLFAAHLPFSALGPLFKARQLIRGTLRVNKRNRSDAYVTSDDLESDIYICGSRDRNRALEGDVVAIKLVDVEKVLREKKEKEEAKLARNGGKVPTRRPDEEDENEIIFGGDEDIDKVKPKYSGVVVAILERAQNQVFSGSLTLMRPNNKRSQDDKSDESKETPRIVWFKPTDKRVPLIAIPIEQAPEDFVTNAVGYENKLFVGSIKRWPITSLHPFGTLERELGVIEDLGVQTKALLADNNAAMSDFNDAVKACLPQTPFELSDIEISQRRDLRSQRVFTIDSKGTKIQDNAISVQRLGDETFEIGVHVADVSAFIEPHSPLDKEARARASSVDLVHHTVPLVPESLTQEITNLSLNQDRLALSVIWKISNEGKVLDTWLGKTVVRSSAQLTFDDVEAMLAGKSAEKTYGELQNQLVEDITILDEISTNMQSTRCKNGAMHLSRDELEFQFDEDQVPTDVTLKKKNAMRRILREFKILANISVAQKISSCLPEQTILRRQAPPAESKIVELQQYVKKLGLDISISSAGDLQKSVDAIEDEQVRKALTIVILKTLQPPKYFCTGTMDILKYSHYSLNIPLYSHFTSPSRRFSDLIVQRQLKCALDKEANFYLERDTIQKTSQHCNVKKEAALNARYQSSMLFLALYFNNLAKKANSNVVFADAIVVATFDGYFDVVLTQFGFEKRIHADNLPLNSHQFSGNTDSLTLFWQKGVSTTALNREFTYLEDDDVEIELDEDAIAEEMQKDLSSEDGEGHTNDKSDHKASTNGTAEAEVKALSITQQAEDTNNAPEKNVVAYKRLSKRNSGAIIPMSATNSSSGSQTPISVPSYDGLQCSQTLKPLDSIKVAIHVEMTQTPPLLRVLAANPFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBT3</accession>
    <name>A0A8H7UBT3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LYR motif-containing protein Cup1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBT3"/>
    <dbReference type="OrthoDB" id="5521299at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20273">
        <property type="entry name" value="Complex1_LYR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046896">
        <property type="entry name" value="Cup1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20263">
        <property type="entry name" value="LYRM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYR motif-containing protein Cup1-like N-terminal" evidence="1">
        <location>
            <begin position="13"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2174143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="377" mass="43388" checksum="D0D4932E704F9D66" modified="2022-01-19" version="1">MLSTTHRQYVLALYKNLLSEAGVFFDDRARLTEWCRVRMFMIRRVKSRFRQCQKLNDIDRIKNKITEGRKYLHGIERANNNDQKCAMRILRAAYGRTGKVRHYLLMPYIDTNPSPDYKPPEPFYAHIPHTAPPPPLCAPLQTLIKGLQNKKLEPELPESRYKPLHLGRKANLLWGWRSKLISKVQVPLPMEILNELELKATSPIVSIHQTMDGGPSWESMYGTRQRRYLSEESDNYVHLSHLDPNSRLIPRRKLRRSQSLQSSPYSSQISTKSPFSVTSMLDLVTESSETSNVIRAVHSIKPRQLRRYYQRLLAEVPCMTGLTTQKALWEAGLRNILFTSTAASQSTQRLLMGDEMPSPEVIEKALSKGKKSKASKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBT9</accession>
    <name>A0A8H7UBT9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bud emergence protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_007812</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBT9"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06890">
        <property type="entry name" value="PX_Bem1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11878">
        <property type="entry name" value="SH3_Bem1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11879">
        <property type="entry name" value="SH3_Bem1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000093">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035550">
        <property type="entry name" value="Bem1/Scd2_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035548">
        <property type="entry name" value="Bem1/Scd2_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035549">
        <property type="entry name" value="Bem1/Scd2_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="45"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="145"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="345"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="7">
        <location>
            <begin position="547"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="253"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="464"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2177155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="623" mass="69771" checksum="23675596C60FC252" modified="2022-01-19" version="1">MSTANPLREKAKVPKGLQSARRSLLKEKISTPVSFPTRHTPSIAPPKKVIKALYDYEAKGPQELSFSQGDFFHVVGKENDRQWYEACNPATNSKGLVPVNFFQVLEKAERILNDGNSIPTNAHTKDSGFGDINDANHPHNQSKRMQPLYGIVLYDFQAERADELQAKAGEPIIVIAQSNLEWFVAKPIGRLGGPGLIPVSFVEIRDAVTGRTITNVTDLMQNPSTPIPKVEEWKKMTQGYEASSILLGSIEKQKKSLESQQRPERPPTVGQMPPLMKTSQEYGRHPDDLGDEEDVYDHYHGEDGILDSYGMQHMARISEDSLTLPKSRSNSPLNDHDAYTDQYHDGSALVISASVDSYILEGDQYWFIVYADIANGRHRVLYRLYEDFYDFQINLLHQFPAEAGKKNKERILPYMPGPLAKVDEEITAERRRDLDKYCKDLLALPRYLAECYLVQDQLFGINEGDIETDYDPRTGRSSRDSYSAGMDASSYQRRQSSPPPPQAPQGQAPVAEQPPVETRSPARKPSSAGKQISPSRAPPGGQPTQSTVKIKIIFRDDIIAFRVAANCRFGVLSDKITERLGFEPLLTYKDEYSGERLPLENEADMDEAFQVALTSGKLTVFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBY1</accession>
    <name>A0A8H7UBY1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003718</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBY1"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20545">
        <property type="entry name" value="CYCLIN_SpCG1C-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21797">
        <property type="entry name" value="CycT2-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="65"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="178"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2179931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="346" mass="39162" checksum="A88D00571BCDF0EE" modified="2022-01-19" version="1">MASPTEASQVEYSFEIMQAISHAKESYTEWPQWYYRKDALVNTPSVANDGFTVKREREDRAKGCNFIQSVGMTLKLPQITIATAMVFFHRFFMRKSLKDYPFYDIGATAIFLATKVEESGRKLRDIVTVCAQKAAKNEKLVLDEQSKDFQRWRDIILYDEGVLLEAICFDLSVEHPYHYLLLYIGELRESNRLAQTAWMFVNDSIKSPLCLLYSPQIIASASIYLASKTIGHELTADEDSDWWELVSSKLDEIEVKIDAVFDILDLYSNAATVSVKGRSSNNLDHRPASEYRPNTPQPNTPGYNNSQDSSVNTPLLAPLASSKLSVDGNSSIHDAMAVDARNEHQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UC45</accession>
    <name>A0A8H7UC45_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_004149</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UC45"/>
    <dbReference type="OrthoDB" id="2160599at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013942">
        <property type="entry name" value="Mediator_Med19_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019403">
        <property type="entry name" value="Mediator_Med19_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28270">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28270:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10278">
        <property type="entry name" value="Med19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="132"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2174129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="202" mass="22916" checksum="280629151FE50E89" modified="2022-01-19" version="1">MLASNGQPRLTGSQDLLSLFHLNGLYDDYVRPYISGNEADALEPTFSNYIGLLPGKFDMEPDNYLMQLIRNPQQIDIGRGIEPFPEDVLRESFSLQQGRIPEFDTSLLGLDEVDSTMQSSVKRMPSIKMTFGSRIGEGMHEAATGDQGIDKRHKKKKKKRKHGHENEEDGHVHSDHKKKKKRKREREPGGQDNESDPVVIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDR0</accession>
    <name>A0A8H7UDR0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003064</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDR0"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15534">
        <property type="entry name" value="PHD2_PHF12_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052819">
        <property type="entry name" value="Chromatin_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="149"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="280"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="407"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2177817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="545" mass="61413" checksum="D67E3399F23B5C3D" modified="2022-01-19" version="1">MAGISQEPTPPPPSRSSPRFQQKEGNKSSIKEEDLQHENEDHDPTSRPKAPIATRTRHGLTHSATPQHTNRSVGHTQKTSEGDGKNTTIEENVRTVEDEDMDEIFRLLPARKKAKLTAARKHALNQRRKAEVENGAGSPDSLPEDKKNNDNCETCGGVGEFLCCEDCPKAFHFVCVEPPMDAKDVANIKGKWFCNECRAKRRPPKPNSKILLGNLGCKLEASNPVLFELPKEIKQFFQGVSSNEFGEYVDSGSIKSVRKGKNGQPEEPDYYRLRDKDGEFILCYRCRKSALDSRQIIACDYCNLHWHLDCLDPPLASAPNTSRKWMCPNHAEMAMNLRKRQRRNPVIIEPDDPLNTPNHGDIQIVEDESDTKWRKDQLFKYAGVVYRIPESAVKLHFVDQIRSIRTDTDQWSRSQESQQLDTDSSSPSNGTVKSSNEDRRISNLKVANSTHPSAEESREARLAALQADIASYLSEDLNSNNFSSDDSRMRMLIRAALGSNTDSKSKDEKVELDRATYDKCKAIESLIQVKGEKALLEFLKSDSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDR1</accession>
    <name>A0A8H7UDR1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDR1"/>
    <dbReference type="OrthoDB" id="2238745at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF174">
        <property type="entry name" value="ARRESTIN-RELATED TRAFFICKING ADAPTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="1">
        <location>
            <begin position="178"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="465" mass="52261" checksum="1F9F883D0F96F157" modified="2022-01-19" version="1">MFKKPVSIELIEPVVYIRGTADRTVQYNNIIRGYVVLHNTGTTAIQAVKLNLIGVAKTIWPEGIGADGNQTCDKKRFINQCIDIDLPHNNVTNRHYTAYSGYNRLPFEMFIPSNIPESIDCDLGFVEYKLVATVYKIRRFPFSSQLVTDMPIQLIRLPTDCTISGDGPVESVSISRALSNFGDYAITIEKQVVTPGTTLPVCLRVLSNVENARIEGVVVKIFERCTIRAPDKGVTRIINHKITLRRTDRISAKLGINLDDLGSGVAWEDRIFYEIPDDRKMRLHASTTYRDISVKHWIQVLVRLSVPNTNSEELDTQPRVFKEVMLDSKFCVLRAGALTEDLVTLPQYSEKIQGNDMSIAWGDLPEYAPECPSVQKPSNTANALLDLASPLHFSKRISYMMKRNKVGQENLSCSTSSGDMPRASTSSRFRFSCKPHTLSATEGLPFANQRYSHSIVHRLQSMDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEE7</accession>
    <name>A0A8H7UEE7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="8">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_007527</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="8"/>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEE7"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000009">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="11"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2176873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="326" mass="36566" checksum="B9C67FCEF33E4882" modified="2022-01-19" version="1">MSAEPQTPAKLQVDLHVKYIQSLNTKQDDLEYWLSEHLRVQGIYWGLNTLDMMDHLDALPRDDLIKYICSCQHENGGFGGHIGHDPHIQNTLSALQVLVTLNALDSIDTDKVVRYVASKQNDDGSFRGDDWGEVDTRFCYIALSICSLLKRLDAINVDKCVEWILKCRNYDGGFGNQPGAESHSGQIFCCVNALAIAGALHHVDRDLLGWWLCERQVKNGGLNGRPEKLEDVCYSWWVLSSLATIDRLQWINADKLTAFILSSQDLEDGGISDRPGDMVDVFHTNFGVTGLSLLKYPGLKAVDPVYCMPQYIIDSLGLPRLHQCNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFC9</accession>
    <name>A0A8H7UFC9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFC9"/>
    <dbReference type="OrthoDB" id="2553298at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027911">
        <property type="entry name" value="DUF4604"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15377">
        <property type="entry name" value="DUF4604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4604" evidence="2">
        <location>
            <begin position="12"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="179" mass="20499" checksum="B1D1963622EFB36E" modified="2022-01-19" version="1">MPKNPTPHQLSKNLEYVQKEAPFLAKLKAKHQDPIKKKFEDWQPQDDDDDYDEFEGAQVVVLKEGKHYSQNDLQRHLRGEDVDLKKKDKEGSVEEEEEDSSPVDASGKLKFRAKKKATGDQAPLVIVGSKALKRKHADNKMETSEDNSGESSKTDETKKKKKKDKKEKKSMLSFNVEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFJ8</accession>
    <name>A0A8H7UFJ8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFJ8"/>
    <dbReference type="OrthoDB" id="2326382at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="116" mass="12887" checksum="641BE0E40AE49334" modified="2022-01-19" version="1">MRVITKEQQDAAGKYAMKGFAIGAAQWACVGVFATAAASVAFPGFKKTPIQNKFYIVMAMALGGGAHLSDRYMVQFERRGRANMLDETTRQRYNLIYGDEEERKKAQEALKQQATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UG97</accession>
    <name>A0A8H7UG97_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_003387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UG97"/>
    <dbReference type="OrthoDB" id="2265977at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2178134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="157" mass="17440" checksum="EA6970AD6D5B0EB2" modified="2022-01-19" version="1">MDCQSLDICFFEGDSVTISGVGTKYGSRFHLICSGFGFIDIDRAFHSAVSLTGHYIPGQPSLIEETYNMLEDGDPMDQEYLDGFGMHHFGFGPTDAEDKNLRAEEDTEYDAIENDHLLQGIINSMINSGDEMLMNRGKKLLGIVWGVSRQATAKFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGF0</accession>
    <name>A0A8H7UGF0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">orotate phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_007032</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="5"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGF0"/>
    <dbReference type="OrthoDB" id="5553476at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046132">
        <property type="term" value="P:pyrimidine ribonucleoside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000008">
        <property type="entry name" value="Orotate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683:SF1">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="283"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="178"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2182105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="455" mass="49920" checksum="2B170F3B432D6BBF" modified="2022-01-19" version="1">MQAFKAGMPEADNAVNWNQQPGVVPQKDHAAAPGPFDDGKAPMSSEQVHANAEYETKEQEGNLMDTDADDAGQDIPPQHDWNGDHEPKTNHPQQIDDDSNWKEEEHIDKQLQHSASGHHSLLWLIAVAFALVILYRANSKSSQAKNSILPLHQNANAGFYSTDIKPQPLMTSPVQDPTIDAKSNRLHPSAARGHHRKTSSISAHLSPRPTSRPASGNDLWSGDWKEGKECTYTYRLLEMKDYQREFIEFCLANDVLKFGSFTLKSGRVSPYFFNAGLFNSGKSIASIGRFYSAAILDQGFKYDVLFGPAYKGVPLVVASSIALYSEHQIDAPYSFNRKEKKDHGEGGSIVGTPLVGEILVVDDVITAGTAINESIEIIKQANAKLSGVIVAVDRAEIAPDGSGKSAIQAVEEKNSVPVSAIITMDHIIEFMTEKGTYGPQLEQMKEYKAQYGVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGL6</accession>
    <name>A0A8H7UGL6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Halotolerance protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_007227</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGL6"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13994">
        <property type="entry name" value="STKc_HAL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000183">
        <property type="entry name" value="Serine/threonine-protein kinase hal4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF558">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="128"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2182300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="428" mass="48356" checksum="A62E35CC42E54C1D" modified="2022-01-19" version="1">MAVAHATYTPPSSTWSSSEKHRAVEKENVKSNQATPASSLSSRSSTRSSEYAHGTDTPRSKLTDVKSHKLNLGMVSKKLFQHKAANDSTGNLQSQKLSTPVVKSPAKSPASSIKSSTTTNLLKKYGTCDKKTCIGRGATAVVRLVHKMDRKDNSDKLYAVKEFRKRRKNETEKEYMKKLTGEFCISSTFQHPNIVETVDLVLDDQQRYCTVMEYCPGGDLYTAIKSQIMDLTSKECCFKQMVKGVAYLHSMGVAHRDLKPENLLLDASGCVKICDFGVSDVFRMCWERKPHLSSGITGSEPYIAPEVFSQKEYDASKVDVWSCAIVFYCMLFDGIPWRIAKKEESNFSLYLRTRASQSFDTFKILSPKCKDLLYRMLDTNPDTRISMPEVLEHPYFKSIQTCRNGFDNLHQEHHHVKLSCMTSSVHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UH50</accession>
    <name>A0A8H7UH50_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_001838</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UH50"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="97"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2178989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="327" mass="36607" checksum="EA093E9E2CB9C0A2" modified="2022-01-19" version="1">MPFSNFRTPRTKRLFITYLKDWIFVILMTAIFFGLDKLPPFRRLFSLQDKTIMYPYAQHEHVPVWLLLILCFIVPLLTISAYSLAVRKSVRDFHNGILGLCLGLSMTIMMTDIVKITVGRPRPDMLDRCQPAAGSVDPPLGLSNYTICTTDLNSYLMKDAFKSFPSGHSSFSFAGLGYLSLYLAGKMHLFDKLGHTYKGFIFAGPWIGALLVAISRTVDYRHHWQDVTVGAILGTGLAIFAYRQYYPPLWSDASDEPFAPRVGLDFAPTSGRDYPHTERYADVDSSQNNLLATDLDDRYHLSSGSSGSGGGPQVDRRIDISKGPNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHD8</accession>
    <name>A0A8H7UHD8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF803-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_006135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHD8"/>
    <dbReference type="OrthoDB" id="165382at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF65">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="452"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="543"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2183140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="626" mass="68309" checksum="4DFC05F668F3C9A7" modified="2022-01-19" version="1" fragment="single">VQQFFPLLSSQNVQSLMDDSPEVNSWIGVVISIVGNILISVALNVQKLAHNRIKNENSAIVLKSNNSSDPIGTQGFFPDDGYPTPRNSEDSAREDGLIDHQETLQFALEDMKPKGKDSNNYLHNPLWWTGIVLMIFGELGNFIGKYPLKLLKLVKPPSNMTTLAYGFAPASTIAPLGTTTLISNVVMAPLILRETFRLQGLIGVLFAIVGASTVVFSSKSEELALSPELIMESLTQLRSIIYFAISGAAIITLTAMSPRYGAQSIMVDLGLVAIYGGYTVLATKSISSLLSMSFTKMFTFPVSYLLVFVLVFTAIIQVKYLNRALQRFDSTEVIPTQFVLFTISAIVGSAVLYHDFDNLEPHQMFTFMIGCAIEFFGVLLITSSRQNRPEPLSIQADDTLENHLLNQEDIVHDLNVESANRSQIDANKIYPMPSSPLHASFPSFKPILSRVEEDETASGKSSNAVPNGTAEHTGQPPRQSEAFASKIIPKSLSLPWHLDDWQNAFNQPIAGISSKSSQHKRRSSLFAGISLTSQLVERMNEDTVAKSGGQPIHLLSTSPGTSGASPHRRTGSHFASILSGLSSLQSDTTREQLNSNEDAVAINIPTINTVSQRSNFNTGQADPNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHF1</accession>
    <name>A0A8H7UHF1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UNC-45/Cro1/She4 central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_002369</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHF1"/>
    <dbReference type="OrthoDB" id="199930at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024660">
        <property type="entry name" value="UCS_central_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994:SF1">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11701">
        <property type="entry name" value="UNC45-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="UNC-45/Cro1/She4 central" evidence="5">
        <location>
            <begin position="131"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2185931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="761" mass="83256" checksum="F5D079A08D4153FD" modified="2022-01-19" version="1">MEGGKVNQEQLSKDIEKISKELPGQDDPQIAKLLMQRAEKYIQLGQRDEASADIRTAVQKDGKNKEIVHSAENLIQRMYTDIKTVQAGNEDKKTTKEDSPKLRQFKEFMHSVSDKDNASTNIKELIVKKDFVDILQSCGDPNESSDVKTAAVIILTSILNSQAMSEKVENGATLLTKVSNIAATCFKQCFDSGRAADKINAFSTLKVLFQANLSVGANIFNQPALLEDIMDTIEFEKTEVQLAFADALAQACSDSHCRKNILTHCSDWLAAAASSRSHKDTNLQIFASIALTKLNNANDKSTDSMGLDASAANGGVDQLANAMREHSISNEQLSNTFMAAIKNNNASDSQLLVATEGLAYNSMQAAVKDALVNDDDICDQLFKLAKEKTRSGAILFGVATIFANVTGYLPVLSEEQKQIKKLRNLANAKGAGKNDQKGSEEQEDPRDRDEAVNQRIEKLVDIGIVPALIGLARSSSENIQAAISQTFLNIVTPQKTRGTIVQQGGAKCLLLIVGTQQKATFVKFASQALAKLAITMDPRIAFPGQSAHELVKPMLQLCQDDFSLRNFEALMALTNLASMDENIRARIYLDKGMPIIEGLQFSDNKMIRRAATELLCNMMFLGPVFESYSDPKQSGAQAKIKLLLALSDVDDFETRRAASGALAILANSPGACSMMINENGYERISQLLQPDENVEVQHRGTEILRCLLENNGKEAAACFVQYQAHLKLVDIVKNCKVQPVRAAAMDVLKLFNQNGITNFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHI3</accession>
    <name>A0A8H7UHI3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHI3"/>
    <dbReference type="OrthoDB" id="286814at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF36">
        <property type="entry name" value="PHO85 CYCLIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="43749" checksum="B397CC6C7D9408C9" modified="2022-01-19" version="1">MTTSEYHQHAGSYAWEAGYGPHRLVDFPSHLSTDLHHYSLSNNQPPLQQVTLHFTPVADQPPQRTHVSTIKSCKYSTPSKRQQEQHTPCQRPSTTANGYQHFMNNDRQERSKFVEKLIETTATVIESIWSNNNIANGRKEVIPTKSFIQEVLKRSKTTYSTLQTALFYLFRIKNIIVARLKQRANTCTKRTSEYSTDDYLCCGRRMFLASLMVASKYLQDKNYRNKAWAKISGLDIKEINGAETAFLKIIDYQLFISKPTFDRWFNLLNLHVDQMQQQQQQQQQQQQRNAEETKPTRMYPTPTASPIRHAPYRKPVQQHYPSPPNSIHEYENAGVSPTAASQLMFTLPDKVQYSPSDEEEIASLALKPRTDEMTPPYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHN0</accession>
    <name>A0A8H7UHN0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHN0"/>
    <dbReference type="OrthoDB" id="2439450at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2183425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="342" mass="38394" checksum="7F145891E6D8D12E" modified="2022-01-19" version="1">MTQDISPSRSPMSRSRSSSFNLRLPTTPEEVHHRQSSNVAELTFDSIDNLPNSISRTESPDIEEARSPRITPSRNQSTTSLTSTATRSTTWSRRWRHRTFRNSIFTTASQLSRPPSYKQQDSRTNDHADGTIRDTSNLGGWHGIAAQFHGIYFAFWLVLLSFLGAVSVFVPGLPQAAIVLWVPVVIYLCVAVFMFHRRRANRVHNDTNEDPSDHTLPAQESMRQMRLPDSYYFVINNTKDHAHPVVTLLPPPPNYRNAAKGAQRNSMEIEELEPTGPETTEQHESQSTSTELPLASDHIHITIQSPSLGSGTPDLGSNEQFESDHHHHQQRITPHSPAVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHN6</accession>
    <name>A0A8H7UHN6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein-lysine N-methyltransferase EFM6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHN6"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF132">
        <property type="entry name" value="PROTEIN-LYSINE METHYLTRANSFERASE C42C1.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2183440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="28178" checksum="F07FAB6AF6658EFD" modified="2022-01-19" version="1" fragment="single">PSADTELLASLVISSLSEVESLAVGDAFLELSLGMEIGNARASKIDRTSAFQYNGLSQSIVIIEDTSGGCGGKTWEAADVSCNYLIWKHEQDNHSAFKNKRILELGSGTGLVGLVLGAICNPSGAKEIVITDQLPMLALMENNITANGLNGIVSAKILDWGTSLPTWMNEKPDIIIASDCVYLEVAFQPLIDTLFMLSNEKTEIYLCYKRRRKADKRFFVLARKKFTFTEACIGRSAPTGLRTTRHTPVLNEAHCDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UI91</accession>
    <name>A0A8H7UI91_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-formylglutamate amidohydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_003841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UI91"/>
    <dbReference type="OrthoDB" id="71260at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.40">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2180054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32490" checksum="E4FDAF5E5F42DAE8" modified="2022-01-19" version="1">MNQQPLQFALDPGTSQYVTYYEGTLPLVLAAPHGGRLFPSNIPDRKLENGTITVTDAYTKDVALGIARKLYEKTGDIPHIVILQLARTKVDVNRDKLEGSDSTAGREVWQEYHDTIKRAIAKINANYDHGMFVDIHGHGHPENWIELGYLLDNYTLKYSDEDLYERNVASTSSIRSLSQRYPDIAFSSFLRGNNSIGNRLSVKHRLKTTPSRSLPYPHRNQKYFFGGYCTQTYGSKNGGGIDAIQIELPKNLRFQKAGRESVIAALSESLMWMLCMFYHDEYRAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UI96</accession>
    <name>A0A8H7UI96_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008412</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UI96"/>
    <dbReference type="OrthoDB" id="1112565at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF16">
        <property type="entry name" value="GH01042P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="256"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="319"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="382"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="447"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2180833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="519" mass="59456" checksum="834F256ED256EBAE" modified="2022-01-19" version="1">MSKVIPQNEPRMSQLLPTVKCSDCGRQVELRKLAIHLCSSVPPVPTLHTAAARVPVGPKAPPIDTRVNRPAMPYAETYTRNESLKSPVADHRQDGYYTPDRNYPQDYQSAPRMPRKPAVNNYYGGSEVGGSPTHLMARDQDQVRDYYGARNNSTSPSPPHRQAPRNGEYARPPTPTYNHDKYGPKPNENYRAREEPTQQAKDWFDDDQYGDFFQPTSETGGALDSLMSDLMSKMTTETPSQPTAIRNAPLNNPIAGACDVCGKGISQNDDFVNTESKCYHRRCFHCALCAITFKDERDCCEHEGKLFCERDYRVVKKRVYCSECDKPISSSQKSIQVLGKHYHADHLHCAYCKQVIDQKYTGMVEHQNQVYCKEDFKQLFLPKCRACGFPVEKEAVSAMDGKLQGKWHRTCFGCQTCHNAFPDNTFYVYDGAPYCKRHYHRLNNSLCRCCDEPIEGPCVQTIEGWRYHPSCLSCSVCRRAITDVYYIHENRTYCETHMLQLQRQRNVRAERRQTMFKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIL0</accession>
    <name>A0A8H7UIL0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_008730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIL0"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01446">
        <property type="entry name" value="DSP_MapKP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18533">
        <property type="entry name" value="PTP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="6">
        <location>
            <begin position="125"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="430"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="631"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="471"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2181148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="734" mass="82962" checksum="386090DEB2DD227D" modified="2022-01-19" version="1">MSVVYNYSPTQSPGDSYFSPSEPTSYDTMDSSQTPYFTAPLSPMFNTEFFQAVQARNSGTPPFMSNGDMDSSSFHAQASARSSRDIPMNLHMGPKTHSSRRDDALNKPVPNGHFTSPDHLNTLLSSNKLLLLDARSFVQYSHSHIRNAVGVSVPTTILRRPTFTLEKLSEAIVNDESKKKLQNWQQAEHIILYDQNSHTLQDASASSILHLYTKFQKQGYKGQLSCLSGGIDAFSKAYPNACVIGQYPTQSRVTTASLPLNAERPLHLNLGKITNGQDSNQRSGPRKMHLSLPPMTAPAPKFENQAFNPFFSNIRQNMELSHGGIKERFPVRLPSGYDINVQSGQVQGAVRPLKACFGTKNGTVVPSWLTNVLLPDNVGPTYIAETYEKIERTEQMRLQNIMQHHSNRASGNLKEHPWSIVSGIEMGSLNRYNNIWPFEYTRVKLVNHKPESTDYINASYIQYIDVSPAELPSHDGKERNDGIPRLDSLSSQNESSMSTRTYRRYISTQGPLPATFRDFYTAVWEQNSLVIVMLTKEEEMNRIKCHRYWPSELNKPEYHGDMAVTMVSEQEEAVVDRNGQANTNPDEVIVIRKLILEKKGSNQQRTLSHIQYKGWMDFGVPDDPLGTLRLIELAGNTQTSYEQQAIQNNQPPVGPMFVHCSAGCGRTGAFCTIDTLMTRLTIQDECMTEEEREGQLDILRETVEKFREQRVSMVQTLRQLAFCYEATLWWILDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIQ7</accession>
    <name>A0A8H7UIQ7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIQ7"/>
    <dbReference type="OrthoDB" id="2396250at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2181283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="257" mass="28927" checksum="79593DCA7F55D293" modified="2022-01-19" version="1">MARILNDWVIDIVTESPGLSAATLSFTFFYYKLAVSQTNRFVMPEDFVHPTIDFCDSSGSGRRNSEEIHDGPYYSTIDDLSSDGGYYSPAENSTTVIQFNQQVHIDQSRLLSSAASTATSTQEDLSQNDQDKEGEVSGSVSDQETSKSQSHAENEAQAQEKTQESKEATASLSLSASSLYDDMLWVREDLLVGGDNLFNVNICRLDDLRQAISRLQKETQILEETDLIIKRKINHVASRRVRMRQDLVEDMDNWEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJC3</accession>
    <name>A0A8H7UJC3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3 6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_008686</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 6"/>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJC3"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023566">
        <property type="entry name" value="PPIase_Fpr3/Fpr4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001473">
        <property type="entry name" value="FK506-bp_FPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="261"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="96"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="191"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2181104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="347" mass="38106" checksum="4FC4DDBC92DB0740" modified="2022-01-19" version="1">MHFLVKVFTSCPARLTLKSLRKLSVFPWYASFGEEIKSQERTCVKVTVDDKEYVLCGLTPKHIEQQLLDHTFVEGEEVTFSISGENAVHLTGNYLPDDDMDQDPYDSDDLMMGSSDEDDLEVDSEEEDEDEDALINGIVTNGAKRLAAAEPDSDEEEESDEEEIVPAPKTKNEKKRAAEAAADASANKKQKAQEAAKKPEAKKAEAKKPEAKKAEAKKPETKKPEAKKEEPKKEQPKATKLANGLLIEDVKVGTGPKAKAGQRIGMRYIGKLKSGKVFDKNVSGKPFNFGLGRGEVIKGWDQGIVGMQIGGERRLTIPAPLAYGSQSLPGIPKNSTLIFDVKLLSMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJM5</accession>
    <name>A0A8H7UJM5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_007155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJM5"/>
    <dbReference type="OrthoDB" id="5348546at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="4">
        <location>
            <begin position="108"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="5">
        <location>
            <begin position="351"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="2">
        <location>
            <begin position="351"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="469"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="509"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2182228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="524" mass="58894" checksum="F635635EE05E68AF" modified="2022-01-19" version="1">METISTPSTPQRAYGKAQQEHGLENKAPIASNKGFLDSSPISSKFYDRDDAPPTPIRTPMKDAANLPSSSLMATSPLVKQEPSPYQYTTSPNTASGHPLVLGSFTDNVTVGRCSAATYQVGRRNRLLSRIHLSIAWNEASNLFELTVLGLNGLKVDDQPCSQKEIVSLHDGSVIDIVGEVVRFQAPEHQAEKKHSDDFDIHTPLHSDLSLLESDSPQPESRNVLQHQGSKALSERLLAVVAESKHNETILSEESEVEQVKIEDEEPLKEEPEEECHKQENTNVNNEKSESLAEPVPEAKDLTQHEEIPHSVTEEDVSSKVEFEANEEIEVAESEPEQEITESKSHEVEPLSKDVNYAELIIEALVFSRKSSMPISDIYARIMATHPTYKAQSQPSWLDTISNVLKDNEFFGQITRKGKTADGTPKENLYYYRSDKDPVEWRQATYTQVGRSARKCTLQDKQYFWKIPPKLGRNRSSYVPPPAQSQDGKRSRNKQDDEDESSNKRLKKKKSEDDDVLTKENVQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJX2</accession>
    <name>A0A8H7UJX2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJX2"/>
    <dbReference type="OrthoDB" id="10265837at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1050.10:FF:000001">
        <property type="entry name" value="Putative Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094:SF25">
        <property type="entry name" value="SCP2 STEROL-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="STEROL CARRIER PROTEIN 2 SCP-2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="26"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="130" mass="14186" checksum="49957CD5BAE67235" modified="2022-01-19" version="1">MSDIKTPGFQSSEVFAQIKESFDALPADQKAKLLKQVNGVFEFVIKNDENKEETFTVDLKKEGSVKKGKGSTKADAIISLSDANFIELASGKLNGQKAFMSGKLKIRGQMMLATKLDTVFKQLAPAKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKB2</accession>
    <name>A0A8H7UKB2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Non-haem dioxygenase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKB2"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2186305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="82" mass="9246" checksum="AE193BB5FC7C7D16" modified="2022-01-19" version="1">MDNIPVIDFGAFDSDPTAVAKAIREACETIGFFFLKNVGIPQPEIDQVFELGKEYFDQPVEQKQKQEIQANNVGYSALHREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7ULT3</accession>
    <name>A0A8H7ULT3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-demethoxyubiquinone hydroxylase, mitochondrial</fullName>
            <shortName evidence="8">DMQ hydroxylase</shortName>
            <ecNumber evidence="8">1.14.99.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquinone biosynthesis monooxygenase COQ7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COQ7</name>
        <name evidence="9" type="ORF">INT43_000387</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + AH2 + O2 = a 3-demethylubiquinol + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="1.14.99.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="8">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.60" evidence="8"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7ULT3"/>
    <dbReference type="OrthoDB" id="275371at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01658">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2184478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="262" mass="29555" checksum="96F1F5AE4B5BCF7A" modified="2022-01-19" version="1">MNEQRQLTTRKWRISRRDREIHVINNLKLVHPPLAMLTTRLTKATVAFASASHVAWAPAGMHLNRAVGKAYSTSTTTETPERKLTPEEVEMIKPMIRVDQAGEIGANFIYMGQIAVLGKDPKLRPILQEMWDQEKVHLARFDELIAQHRVRPTLLRPLWELAGFAVGAGTALMGKEAAMACTEAVETVIGDHYNDQLRQLVQITQNKDIVDLSKTVQQFRDDELEHHDIAVEMDAQKAPFHSLLSNVIKQGCKGAIWVAERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UNH0</accession>
    <name>A0A8H7UNH0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA guanylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_002671</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UNH0"/>
    <dbReference type="OrthoDB" id="200924at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="mRNA capping enzyme adenylation" evidence="12">
        <location>
            <begin position="9"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA capping enzyme C-terminal" evidence="13">
        <location>
            <begin position="63"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="232"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="613"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="709"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="810"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="916"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="269"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="434"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="488"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="638"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="685"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="709"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="772"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="835"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="864"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="933"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="968"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="989"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2186233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1016" mass="113959" checksum="00C6F6F124C90D79" modified="2022-01-19" version="1">MYLIIINYRVELKKMERSYGLGVVFDQMTRLKHASDGVIFTPVKLPYTPGTCEKLLKWKPAELNTVDFRIAVKWSKEHKPIYSLEVVMQGKNFKFYDHLQLEQETALDYLTRWKKNVPDGLIGEFRYDPQWNVTIVEPGYAPTVRKGGWRFVKFRDDKELANDEQVVKKILKSIQDGITKEQLLAHMENIRAAWKAREKGIPMPNPVSKIGHSIKINTEDISKSITANPFTATPAIISPSSNSNPFDSYGEKRQSHGHRDSMSSAEYMPDSRKNSLVDNSKEQKSDNDDTMDRKRSMEEPIPDSDHSNMSDEKSQEPKNVESPQWKGQSVFDTRRKFSEEKLEKLNTVRKQSDDSSIKSATVETPKLESPVKSEASNKSEAATANVDTPMEIDQPVIAEKPPDMTLRQMIESKMPPKFRGGQGKKRSESIKSAIETSPSMGAASQPSPTAESRDVKRSKSDSPSGAIFPVQHSRKLSLSSQPTEGNVAAQQSAPPQQNSISAQPTFDGRHRPAGDNEFGEYRRRKVSSPHNPVAVQVDRTSSPPLHETSKAPKNRKIQELVDHKYTYTTYPPNDTSSAPRYDTMNEAAPMQMSSATIRHQQLLEQRASPYTMASSKSAFATPVSPYQHPTTRNIYSPSEHHSNQRRHSDDRSFASYEQRVPASHWHSSPSAPPSRRPSHDEPNHSAPSHSSRAQPSSIADLLTTTVEVTPPSSRQATESPVHSHRDRPSSGSSDRANPFDFAKILHSPSQRQSDEEISNRSPNGRRPPPGEMSERSSDEGAYHQYSSSPRNAVHFINYRTDINQVRPQPMAMEAQARQESISSGSKPYAAHSHMQGRSNSTHASPRSATSSPDFRGYQPTHIVSHSPTYSSSSFSPTATYQSPQMANVNRGPPENMGGVRYNNGRQAVPREHPMAAPYRQSSYPQPYGYHSPVMQQHSASIPPNDDANSQYRRQPYQEPVQKPMVNAYQDSQYSLAQRSPRGGVMENHPPPEDGEGKNHSGNNRTKSKLDFILNYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCU5</accession>
    <name>A0A8H7PCU5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sulphur transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_008280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCU5"/>
    <dbReference type="OrthoDB" id="10254418at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046513">
        <property type="entry name" value="DUF6691"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp_TsuA/YedE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YEDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574:SF1">
        <property type="entry name" value="SULPHUR TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20398">
        <property type="entry name" value="DUF6691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2171554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="33240" checksum="77F46F870D60E0A6" modified="2022-01-19" version="1">MFTPVQSLFGGGLLFISVTSLAAYNGKVAGISGIINNTIFGDSAPWRRAFLAGIGAMGIMLKFIPQLSGGHSVPAFPFSIGKAMAAGLLVGAGTKLGSGCTSGHMLCGIARLSKRSIVASATFFATGAATVYFTGGVPPRYNTVYPSKDELSKLILFITAAASTFELLPAMIKKKARDSTSQSIVGFLTGLTFALGLFLSGMTNTEKVRGFLDLTRPQNWDPSLLMVVAGGLVPNMIAYQLFLKKKEKATFNSRFDWPTKKDLDSRLLLGSALFGIGWGLCGVCPGPGLVTLAANPSAGIFAFWMSYLLGSGAAGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCW8</accession>
    <name>A0A8H7PCW8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_008324</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCW8"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034456055" description="ATP-dependent RNA helicase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="74"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="273"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2171598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="437" mass="48303" checksum="EC55317AE167F22D" modified="2022-01-19" version="1">MIVTTRLLWLSHCSRVLGATRKSAQGPAFSVIRARLLTTDSSNFESLGLSKATAQRLTTAFNISEPTAMQRQLIPAIVSGKDVLLKDITGTGKSFAIATALVDIREPALYVVPNRELALQISGWVEKLTPDSPAQLVIAGEEHHTDHSNSPLTIGTASTMWSLVQNGQWENKRWKAVVVDEADQAFRLPGRYAHWKKRWNRKAHPKPAELVLETIMTAQASKPQVIMSSATMNRPLRHWLMEKQWIKDAVYINGLSPASAGVQHHCLIVSSDQVRNIQTQIDDEVVVGDVATDQDIDESMMECLETLCSIEPVKQGIIFVPNDGSFSQVMSKLHECDIDAIPLYESIAHGTQAQFYVATAMTGRGIDLPNISHVFIVGLSKTIDDYMHMAGRLGRLGQATDTAKVITIARDSKYVEAKVNSMFKLMNTSISMYAHVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCW9</accession>
    <name>A0A8H7PCW9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_009031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCW9"/>
    <dbReference type="OrthoDB" id="10025511at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF827">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="289"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="835" mass="92570" checksum="0A32C54E7A7F1BBD" modified="2022-01-19" version="1">MSDVDTELTQLELAPQLRANSSFMKIMATLFYYGNAAMNAAQLVVAVRALNLLPLRGETPRSTIQGIISTSRKTARDLNLPDPFQIDRDNSARGAVYSIAPEVLNGAEPMQGHDVPDEPIVLKPVRRETSSSAGSSSIHKRPRKAPKPYEPVAFRQSSKSGKLRRPGSKSTNGSSKDRPRKVQYRDDSDSDLFSDDDVDVSDDSASGTGTPNGSRSNSRDRPPIDDDTINVYSLLYAPPTDDLNYIQTANVERYPAASHFAISQQTGYSYPRFRSHDKVKIPKDCCEDRFAVCDIKLLDEKTNELQIGGRAFVLTDGHGGPGCSEYFIRNVPNAIQEICAKYTADQVSELEVQVKLETEFKDMVTQLDEAFLAIKREEFKKQAELMEEDKAKKLEPSPATEGGDPMETDENATTENPDTKVNNDGCTLIINLLIGEWLVNINVGDSRTILMSAPVCVKGSANGFDANRNMGGGIDQNYKLDVVFASQDHKPYLEHLAREIVDKGGEFVDSVQNRVIRVDLDKTKDESNRHAKRLALKHARIRPRDYQPPAGHEYWKANSAPNSPYTINGNGQQVKVRIRDDKIPSLNVARSCGDLDFKMDPNRKIISCEPDVTFVRVLDHNYRQQALGNGASTENNVNATNAPTNPRRYFLFVSSDGCFDHMHEDVPEKQNRIIAKGLGHFLEDGEKFGEAYWGREEDEILDAIEKQAKEATASTAASTITDGDKTTASTNDSTNIAEPVKPEQNMTMTDHSGSAQPDTAPMQTDTPVVDGIEKPTPRPCLVVPPLSREALKARRIKERILSNAVRYFTNREGDLGVFSSTLQDYDDCTIILTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PE10</accession>
    <name>A0A8H7PE10_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Sodium/potassium exporting P-type ATPase 1</fullName>
            <ecNumber evidence="19">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">INT43_001410</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="19"/>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PE10"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140352">
        <property type="term" value="P:export from cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000016">
        <property type="entry name" value="Calcium-transporting P-type ATPase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="730"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="762"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="811"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="853"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="895"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="926"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="24">
        <location>
            <begin position="15"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00073741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAG2171934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="968" mass="106722" checksum="2526E97A7C1DA04E" modified="2022-01-19" version="1">MSQQDMSKTFDQKRPWHVMPESDVVAALDTDSIMGLNMAAVEKRLLDCGHNVLGGDNSNGWFKVLVHQLADAMNWIFLALGAVSYVLQDYITGSILIALSFANLYLSFSQEYAAEKTLAALRNLSSPSAMVIREGKECTVDSKDLVPGDILALKEGDSVAADIRLIYVSNFEVDEALLTGESLPVKKTVGEAEEVDQPLGDRTGMGYSSTIITKGRARGIVVATGMNTEIGKIAKSIEQSDQGDRTRLQKTLNKMYIVLLATAVLCVIIVLAANKFVVDHDLGMYAITAALSVLPAGLTTVLTLSLVLGGQEMTRHRAIVRKLKCLETLGSITHIFSDKTGTLTQAKMAVVRFWLPSTGYYFVSAKGLAPTGDVYATTDYLEDRPVESKHASKIDKDNISEELRELLHCSALCNMSSIYQDIEMDKEDPDSWIASGAPTEVALQVLAHKFHLGNPTLLANGWKLIYEYQFDSTIKRMSTLYQKPNSNHFTLYTKGAAERVITLCGMDQDKQNQILEHVNALATKGLRVMALAYKNVDKLDEAELDDSRDIMESNLTFIGLTGIYDPPREESRKAVHEAHEAGISVHMLTGDHEATAVAIAKELRILNVAEMSAQQIDSLVTTGPKFDALADDEVDKLPALPLVVARCSPETKVKMIQASHRRRDIAAMTGDGVNDSPSLRIADVGISMGKNGSDVAKQASDIILTDDNFATIIRAISEGRRIYQNMQRFLLYYWIALAACAIVILVNLFVRDTSGNPVAPFSTIQMIWFYVIISPPAAALSVQKASPTVMKEPPRPPTESVFNREIILDTLVYAVVWAGILLGAFYIVLFGAGNGVNAVNCDANYTDGCYSFYRARSVMIICFTYTSLVTAIHCRSYRRPEWSLRGLKETWKSTTMMGTLVFDTVGLLVFVYVPKVNVQGFRQLDISWEWGICFAVILLWIAFGEFFKLLKRQFLKPLSTSTTPPLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEZ1</accession>
    <name>A0A8H7PEZ1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_000059</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19311at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000001">
        <property type="entry name" value="Ral GTPase-activating protein subunit alpha-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046859">
        <property type="entry name" value="RGPA/RALGAPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF11">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN CG5521-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20412">
        <property type="entry name" value="RALGAPB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="4">
        <location>
            <begin position="1782"/>
            <end position="1993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="757"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="868"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="914"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="955"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="757"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="774"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="795"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="810"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="955"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2172712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="2002" mass="223647" checksum="5B993D8E0BBC3C9B" modified="2022-01-19" version="1">MSDKANELPKEPNVPHNTTSSAAKLLRRSSTVSRFKKKSNTFAHTEEKHTRSHSELPTPEPASPEPHIAPTLPISKDERNDKLKKKAKNFLDERQKIKTRAQSLWSFIDATNNFDQARFFQENAEQVFQVIFETCMSQIEKIKQKTDRPTSWHSKELTSLQKTLLLLRKMFLYVPELMRNGWQRQNIATILSHILDHGNHPRLRALGFHLLLLWLNDQVVEYPECMGLFANAISLDLFLLDDIQAVSSGNPTQDANSTSEDKDYRPSQNTNGGLQFVKRINERNTEKAFGHGLDRHERIKKANRDLRQSIISTGPQAPLFPNPNPPTFNDSISLIHIFLFNFVRLAYVAVGSQPPPDEYEFPPGDTYEMDDGIATGMGIDAASASAKFLFRIFRTYYLSKFFPATAIELKLEGVPKTGSLSNGLDAKCTVPSTHPSYLPSASSPAVPIVKSIILGSPQSREIIHELLRQSLILPSTNQDYRTTVRAAMHVLGVWAISGEDERPAFLRRSSSSGGYHGKGGTFSTSASNTSLASMGNSQITLSQDNVDADEASSSSLKRSSSNQTTADYSAANVYLRRYFLMVQTIFDHIGENSTDLSRYRNRDAVAESVQNTSDWEGLVNLYKDALNIYRAIIVADNGIEIETQSWEVILTCLMNIRDKLMNSTEKYTLIPVHALADDLADFVCETLLAAFARSGTTNSELWMRLKNSMVSAHRWPQLLNQWVKHMHLLTKILAMRLYLVNLDTEFASHSKHNMSDYFTGNRHSSQLNQGSKSRANKTRSRHQSIHGDPRMLVNRSGRPVSSGSSGQLYELNQSERSLPSASGHTSSPGHSADVTDAEPQNSSTSSLLGSSNILSRNFKVGDRRSAPFSAASAPINDGRHRDASTEDLVEPPSTSRPISTSVSCCRFEINVQLKDKGSSSPPATEGFNDAERSVLKKEPGSITFSSKFVDLHSDSKAERDGDKKSINSIGERQLTDENLGIPSKSNRTSTSSFQHVLDNNYLSSSGHGGEFPAAASLAVFDSSEFMNLHSMNWSGLAILKVWKNMICVMGNVNEIQSPYTHAIAMNCLVDIWDTLALVRAYQPYKATAVPALYELAPWFFQASDLPPSHSLGRATAYGVLCRMMCQRADQEVPDGYYPLFYQTLLDALSRPDEVAVQAILRNSIRLFSLSLPGVNILIPAFIACIRKELLEAPGVLRYTPDDVRSSCILILGSLTSVSYELDKLEVELSPKAAVLGKLQSHRFKFLQVKLMLKNLYIDLIVADANMRRLAKYTDSHCMLINGLSSLLAHELILGSSNYNREIVHPGLNILADRLYWSNLPVVAATCDALYTLISCYTHDMDSDKMIIKTILSKLVDALNVHLKFYDRTVRNGRCIIISKLFSLLVGWLMVIQPTVFTGSELCHLVFDTIEYALNITAAEMEKLLPHPPVDVGENGKQEPVLSFKVNPDHRPKFSANDMVMVNDLSLDNDDTDYVKESSEAALLHLLHHFNNFPPPNGPATINSNILGPGISNDEKVDAYHEQFEYFSFNDHTILAVVEGPTRGIEESPNRLITRDVTGRYAWDLDLFYRPTIDASNFDERDNHSSVEHISDIASNLKLRDGLTLQSIPSRPKAPMPAVMRSYSQLPTWSTSEENTDMLGKLLCYIGESSPDCLLDSSVPLNAPLPLSQPHSNMVMSMSEHLIQHLGSENYLCPEQPSDIKSWYRQSERNPNSMKSNSDLQLSKSASIAKSFTPVLPMEADEPLIPFQQSRLFMSHMGLINYDYLREGQFQMLTKSPALFRDLRGLDRKHGRETMKIALLYVGDGQEDEQAILHNSSGSAAYDAFVNSLGWEIDIATHDGYLGGLERSLTNGTKTTYYCTSTLEMIFHDATKMPTDNSDPKQVKKKRHIGNDHVHIVWNEHHRDYRIGTIGGDFGNAQIIVTPLNNGMYAIQIYRDSKVPLFGPLLDGMVVSHAVLGHLIRETAINAFRATVHPINQALYKHAYSQRAADIHTITQRHKASKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFB9</accession>
    <name>A0A8H7PFB9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFB9"/>
    <dbReference type="OrthoDB" id="2449040at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="456" mass="47273" checksum="D4BB7CE653586BC8" modified="2022-01-19" version="1">MSEPVVEQQPTVEAPISESVPATTAVEETTAAPADISEEAPKTEEAPKAEEPTSAPVAAETEEPAVETPKSEKRKSKIFDLFNKMKVSIDLMYHDSCGCSPVKPDFGISKKKKKKLKKLVTDKHRSPLQRPTSPNGTAAKESKPETTTEPVVATPAPEPSTGEPVEAAQTEPASTEPVASEEVAVVPTEETKEEENVAKADKRRSVFSFMNKIKLPKSPEAKPTGNPITEEVAAAPAAAETTNEAAAVPEPTAEPIETAEEPAVAAADATGPAEEPVVAGETPASPSDKAKKSVLGIFNKFKQAKPDNKTAETTAASTEPAAETAAETAAVPETTEETPAVTETTAAAEPEPVAAEESAAVEAPATEEKKTPSRPSSPLGRSLSKFYGRVSAKFPKGGKKETKETAAETAPAATEETAAAAEPTPATEEVAAPTTTEEETPAAAPVESTPVVTASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFQ1</accession>
    <name>A0A8H7PFQ1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">White collar 2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_004487</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFQ1"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658:SF18">
        <property type="entry name" value="PROTEIN GAT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="47"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="7">
        <location>
            <begin position="361"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2173114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="44415" checksum="5DE10E54F5A31CC3" modified="2022-01-19" version="1">MTTDDKLTHKQPAYTVQTFSFNPAASSGRNPTQTGSSRGALTEFTRRKNWSQRIIDRLEDFIHVLSPQAKIMYCSPATTELFGYAPEDLIGRPIADFIHVDDVDLFRHEFTEVCLQRRKFHLYYRFMKNDSTYVSIEMVGHAYFGDGLKQPAATTPMCFFGCGKIYPNKASDAINSFLELKMEKEMLERQIRDAKAKKQQQQQRVSGKSTSSKESSPAESQQSEEPLSRGTDEITPHPTRVANAMGMDMFPLAPTNLNNAPFVYTLGVNPQNDISEALQMFTGLRYDMGERSNGISTGSTAAQLLDPTLDLSALTGSLLDPTPIQILNPASFATQQKLEASTSDRTKRKKRTKDDTVVHVCTDCGTTESPEWRKGPKGPKTLCNACGLRAKKNQSRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFY3</accession>
    <name>A0A8H7PFY3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFY3"/>
    <dbReference type="OrthoDB" id="2444472at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2173234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="42" mass="4725" checksum="2115D52FBB62A841" modified="2022-01-19" version="1" fragment="single">LRTIIISVPFIVTTSYILYKRVVLGEQPRANDGKPVRPKGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFZ7</accession>
    <name>A0A8H7PFZ7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_004636</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFZ7"/>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="20"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2173262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="458" mass="50068" checksum="550FC7969C84E594" modified="2022-01-19" version="1" fragment="single">EKQEYHEEPEYRTYPIRYFGLLMLVLLNIVTSLNWTVFAPAPQFAADYYSTSLSTINWFANVYLLCYLVSSPISSWVFERYNIKLGIITGACLQLLGAWLRYFSVFVGNAQGKFALAMIGQLLCALAQPFILNAPTPYAATWFTPEARATANMAGSISNPVGVALAELIIPALITDESHLPFGLLIVACITTAIAIPTLFIPPAPPTPPSPSAAANSRNDRRPYLADLKLLVTNKYYLVLLFCFAIFVGIFNAMSTLLNQIVTPYGYSDDQAGYMGVAMILGGLVGAIGMAIFVDKTKLHKVAIKTTLFLSGIMYLVLYFVVKENNLTTIIAICTLIGILNFSALPVGLELGVESTYPVSEAASSSTLWASAQILGLIFIEVMDALRYPADQGNPNGNMQRALLLVAICALVAGTTSFLYRSRNYRMESEAMIASTDVEHNIDLDMIDRKVDSKGEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGR9</accession>
    <name>A0A8H7PGR9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_005107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGR9"/>
    <dbReference type="OrthoDB" id="2098303at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2173687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="93" mass="10636" checksum="A83F8AABBF4A15F0" modified="2022-01-19" version="1">MPMSKELENVHHQLSAVQSEAKQLSSGSFTEEQLRHLQNKLHHIDEQYKEGCVMAGNQSQNSDPYEVDGQAEIAEELEKVHQDIYGMLNQLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHJ7</accession>
    <name>A0A8H7PHJ7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_005235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHJ7"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035539">
        <property type="term" value="F:8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04678">
        <property type="entry name" value="NUDIX_MTH2_Nudt15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099">
        <property type="entry name" value="8-OXO-DGTP DIPHOSPHATES NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099:SF5">
        <property type="entry name" value="NUCLEOTIDE TRIPHOSPHATE DIPHOSPHATASE NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2173815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="178" mass="19962" checksum="D5CEBC00B4FE4E0E" modified="2022-01-19" version="1">MVESQEPRVGVGCFVTRKGAEGSPDSFLIGRRQGSHGAGACQLPGGHLEFNETFEECAIREVYEETGLTLKSVEFATATNDIMKGKPLQSSISVKPEVNRILCRKSITIEENRHYCTIFMKGVVEPDDVQNLRTMEPHKLDGDWAWITWEELLNGGDQIRPLFIPLQNVLATRPSFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHN8</accession>
    <name>A0A8H7PHN8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-homologous end-joining factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_004187</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the XRCC4-XLF family. XLF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHN8"/>
    <dbReference type="OrthoDB" id="2155935at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045027">
        <property type="term" value="F:DNA end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22285">
        <property type="entry name" value="HD_XLF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.10">
        <property type="entry name" value="DNA double-strand break repair and VJ recombination XRCC4, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052287">
        <property type="entry name" value="NHEJ_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015381">
        <property type="entry name" value="XLF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038051">
        <property type="entry name" value="XRCC4-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235:SF1">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09302">
        <property type="entry name" value="XLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XLF-like N-terminal" evidence="9">
        <location>
            <begin position="15"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2174167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="528" mass="59859" checksum="8D4B8531914CD8E6" modified="2022-01-19" version="1">MFIDADKNDLLAKVPWTTLSALYNNQLYNNQLYIKKLFDDDYYLVLVTDCRNVWLEHVDASAIYERARESEITVDEDKPERLVALIRILRTFLDTIQEVKQTADKLEIICSRKVGFANVPWVFHCARMTSKEPSQSVFDGPETLYKHLVAPTLVLGSTYQTLYFQQRQQLIRMEQELNHLHELMDKAGLGTPSSKHSITDEEQNLKFLTNTIERLASQKDAMLQLMTMPSSELMIKATQAVITEIKGGAQDVKHVVHNASAGTDYNSPIQEDLIIAAGLQDTLKGRSQPPSSLSESAVGTQNAKTNKEIEQEKRAALRMAMAEEESFTVLIPLTSSSSYEFLRQLRIFDHVLTVCDSQLPDLNATSCNITLSQAYGANSLHLQTVDMFDAALKLKPDEQVFLKADDDLLFDYDYMLQVEDTMKRNGNVYFGKPSTCTTEVDGQRLQQCMEGRVYGASRSLIGCFVDSSHPVGLDRKLTSSYFGDAVYKNCKYLGVNYLHADDQHIWYDRFQDMNKCALFNWNNNLGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHP1</accession>
    <name>A0A8H7PHP1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP synthase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_004173</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the eukaryotic ATPase B chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHP1"/>
    <dbReference type="OrthoDB" id="67388at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008688">
        <property type="entry name" value="ATP_synth_Bsub_B/MI25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013837">
        <property type="entry name" value="ATP_synth_F0_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733:SF3">
        <property type="entry name" value="ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE B CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05405">
        <property type="entry name" value="Mt_ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161060">
        <property type="entry name" value="ATP synthase B chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0138">CF(0)</keyword>
    <keyword evidence="3 8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2174153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="239" mass="26445" checksum="896E1C055778D64E" modified="2022-01-19" version="1">MALRLLTKGAAVTAARPMLTASRQTVGAHFVRNYSSNEVEPKKKAASIVDSLPGNSLVSKTGYVTLGAGLATFLISKEIYVFNEETLVLVAFGGLAGALFKYLKEPYNSMADEHINRIKNVLYKARNDHKSAVTERIEQAGQMKDIVDVTKNLFALSRETAKLEAEAFELKQKVAVASEVKATLDSWVRYEATVRDREQKQLAAYLIEKIQKDLEDPKIQQQILDQAVVDVQKLTAKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIU6</accession>
    <name>A0A8H7PIU6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fructose-1,6-bisphosphatase</fullName>
            <ecNumber evidence="5">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">D-fructose-1,6-bisphosphate 1-phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_005839</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the FBPase class 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="5"/>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIU6"/>
    <dbReference type="OrthoDB" id="10256725at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000002">
        <property type="entry name" value="Fructose-1,6-bisphosphatase class 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000001">
        <property type="entry name" value="Fructose-1,6-bisphosphatase class 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006778">
        <property type="entry name" value="PRK09293.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556:SF1">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class I N-terminal" evidence="14">
        <location>
            <begin position="22"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class 1 C-terminal" evidence="15">
        <location>
            <begin position="215"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2174777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="339" mass="37057" checksum="B07B117903E0EE52" modified="2022-01-19" version="1">MSDIENKDLFTKINVGSGTDLMTMTRYVLAQQQASSDATGDLTILLTAIQFGCKYVASKVKQAGLINLLGLTGEANVQGEDVKKLDVLANDIFRNALIASGKVSLLVSEEDEHAMVVENPKERGKYIVTFDPLDGSSNIDCGVSIGTIFGIFKVDDAKNIGMKDLIRSGRNLVAAGYCMYGSYCEMILSVGNGVNGFTLDPAIGEFIMTHPDITLPSRGKIYSVNEGNMKYFDEPSKNYVNAVKQKYSARYVGSMVADVHRTLLYGGIFGYPADSKSKRGKLRILYEVFPMAYLIEQAGGKATTGTQNALDIVPEHIHDRSGVWLGSKEDVEELESYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PK20</accession>
    <name>A0A8H7PK20_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PK20"/>
    <dbReference type="OrthoDB" id="2285112at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="527"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2174934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="551" mass="61948" checksum="4A89C58AE2095DAA" modified="2022-01-19" version="1">MSLDNVQVNMSRLALARAIKTPDGDDTEADPWNKSIIFNQSHIPQAIEQHRRQEHKRSSPAPRHGRGSRPQQQKISPQPALPQQRKTSPQPVNDKSTTRVRKTYIPSDDEEDEEEQEEEEDDEDDESSDSEVEKADSQRKQSTSATKSLPMESPAKSSNMKSARKQPLPSDDEDSSGSENEDDDDNSSVDDTGVQRHSTPMHLQNDTRSSSTGSSNDGNLSVHHRSRSLGDMMDSPSRSPIPRVQQDVALPLHNEQWRKSGDVMGRSSDMHEGQFPTKAYRHGRSKSSDKLDKMPVAVPTTPIPGRPRRKSTMVDYEGTHQQQKPSYHAAPQFGQFQQYPPNTNRMSQSNRISMSGMDMLMQLEHEKQQAIKGKPKKIDSTNAPIEGLLAKLPESGAYNVNFQQLQGHQGHGSRTHRMETGARDSHKTSRGRPNSAMGYFDARPNVSQSPSPSPDHRRSRLSPRLEAPYPTSSISTPASYLQRQYQQQMMMMDQQQHMMQNQYLMSSQMLQIPMNYGQMMPSVSPDAAMRQSMSRPSSSMAKRSSSAWGPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PK52</accession>
    <name>A0A8H7PK52_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UAA transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_001053</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PK52"/>
    <dbReference type="OrthoDB" id="999962at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005464">
        <property type="term" value="F:UDP-xylose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2175406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="36766" checksum="9DACFEBBC6043A82" modified="2022-01-19" version="1">MLKLLCCSGQLITLGQFIFVAMEGMLYHVQWPSPAGTWWPTFLPSLKPRAVPIQRWIILVVVFYLVSALNNIALGFEISMPLHIIFRSGGLIVNMIMGWLLLNKRYSKGQITAVVLVTIGVVWATLASTSAEKKKESSSSGNEFALGIFILSVAMILSAGLGLLQEVTYRKYGKCWREGLFYTHCLSLPIFLFFYKDLLAQLDIYNKSALVSPLQAIEHLPIAASLLSAFPFNIISAFKIPKLWYYLIMDVLTQYVCISGVNRMTAVSSSLTLNLVLNLRKFTSLVISIVYFNNPFAVGAIYGSVLVFIGTILYTQSPTIQPKSTAEKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PK89</accession>
    <name>A0A8H7PK89_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PK89"/>
    <dbReference type="OrthoDB" id="2130735at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034852636" evidence="1">
        <location>
            <begin position="24"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2174766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="123" mass="13758" checksum="E96EBB2C3C0AADB4" modified="2022-01-19" version="1">MRLEKKIFFILIILVSAISVAFGDTNSQLLYTPAKPKAEFNQYARTLNGRRLTTFEHLPADAKEGAAAPFIIRFSDTHGSTCSTMGTVNNPLTTLDIQLLVCGYLFSLSFLRSWEIIIKEHSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKC4</accession>
    <name>A0A8H7PKC4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_001100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the methyltransferase superfamily. METTL16/RlmF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKC4"/>
    <dbReference type="OrthoDB" id="514248at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017182">
        <property type="entry name" value="METTL16/PsiM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393:SF0">
        <property type="entry name" value="RNA N6-ADENOSINE-METHYLTRANSFERASE METTL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05971">
        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037350">
        <property type="entry name" value="Mtase_ZK1128_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037350-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2175453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="395" mass="45110" checksum="8E9C47134D1290AF" modified="2022-01-19" version="1">MRRALTKCLFKKDFGLDVDIPENTLCPPIPNRYFDCSTVYCYNNDGYLLSECQLDDGTVRGIDIIKDPNYWKEPNLWHIDIDPNSIESAQNNIEKNSLQSRIKIFHNTNSSCILPLDELENQGYISQDSQITFSMCNPPFFKSIEEIQTGMDAKLDEPSAVCTGTHSEMITDGGEVAFVTRMVQESILWKHKIIWFTTMIGKRDTLAKVRQEMAVNNIDNYTVTEFNQGHTKRWGFAWSFGDKRVADNTDDLTTAKKLRQVQAPKIQFSTQLPADVTKSKTEMQGMLNDLDAAIISLNGNQIAGSMYSNTWSRKARRQKAQNVKIETTKAETEALFDFKLTFDRIDDEKTKVTATWTKGKDRSIFESFWNHIKKRIEQVFGIVHGDKFGQASSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLI0</accession>
    <name>A0A8H7PLI0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_005588</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLI0"/>
    <dbReference type="OrthoDB" id="429183at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38483">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38483:SF1">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2176354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23509" checksum="6CADA716AE0D41EC" modified="2022-01-19" version="1" fragment="single">KYQSFFRGQQLPTRTQHGLTRSEAIQGMANRFMYSKFYIILYLGLAGLSLVSIILSLAETCPSLLFIILESIINFAMISEVSVRMVALRRVGNSIAYWRSVWNVIDTILVVLCAITLIVIASGCSASERSEALFDTILLVIRNCVQFFRLFMMMRKNQHSLSTRSARIDFDDLRDNPRNASVEFSAMERAVSLDGGFLDDSDDEGRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNI2</accession>
    <name>A0A8H7PNI2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13 14">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3 13 14">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_007664</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 14">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3 13 14"/>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNI2"/>
    <dbReference type="OrthoDB" id="10253702at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000018">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000005">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 13 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 14" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="17">
        <location>
            <begin position="17"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="16">
        <location>
            <begin position="200"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2177010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="413" mass="45722" checksum="C91D9930966A2FBB" modified="2022-01-19" version="1">MGNILVSAHNSPHFFQVIKYWGKRDTGLILPTNDSLSVTLSQDILHSKTTISAAKEYTGDRLWLNGKEEDITKNKRMHNCFRETRALRKQLEEEAAQRNETLEPLSTYHVHVCSENNFPTAAGLASSASGLAALVFTLAKLFDLPNNMSELSRIARQGSGSACRSLFGGFVAWEMGSNADGSDSLAVQVAPETHWPELEALICVVSDAKKGTSSTEGMQHTVNTSPLLQHRIKEVVPARMAEMTKAIQNKDFQSFADLTMKDSNQFHAVCLDTTPPIFYLNDVSRAIIRIVTEYNNSSPDGKLKAAYTFDAGPNAVIYAPKENMREIIQLIAHYFPGSSDTYFVDHYKLFESTSDVRSNFKPANHTNFNENAIPVFPEGSVNRLLHTKTDDGPRVLGPEGSLLNEQGLPKRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PP73</accession>
    <name>A0A8H7PP73_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_007942</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PP73"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="17"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2177285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="502" mass="54563" checksum="28C4068A5E21EF0D" modified="2022-01-19" version="1">MDEEVPKKHSQFALYVAAILAAVGGFLSGYDTGAISGVIAMSQFTDRFTVMDGNTYVQGLFVAAILLTAMLGSLITGYVADLIGRKWTILVGSYVYALGIMFEIIGYNFGMVVAGRLIGGFGNGLLTNSVPLYHSEIAPAKIRGRLICLFQLMITFGIVVAYFIDLGASNIQGDMAWRTPFIVQLIFAVGLGTAMYWLPYSPRWLMDKGRTEEALQVLANMRADGDINDPAVRREHKQIHDEILLEHELEIRSYAELFKGTVLKRTIIGLFIQSAQQWTGINGVLYFAPSIFQSAGLSGTTMSLVATGVTGICNFAATIPAVIWIDRWGRKPTLISGAIIQGIAMFVIGGLFQTQSAVVDGSLVIQSTNATNTIIAFIFIFTLAFAYSWGACGFIYPAEIFPMRVRAKATSLTTGANWLFAIVITFITPVIIAASSSALYFLFGGCCVLMTIACFFIPETAGRTLEEMELVFGDDPAIEKRAALELGVKEEEYDDIAAVHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPZ4</accession>
    <name>A0A8H7PPZ4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_003305</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPZ4"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2178052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="287" mass="33247" checksum="468E96F61C3FFAC9" modified="2022-01-19" version="1">MQDGHYASNPAWADVQPIPQDDGANPLVPIAYSREYSEAMDYFRAVSRTNEKSQRVLELTAHIIDMNPAHYTIWQYRQSLLDALKVDLEEELNFIDELAEDKAKNYQIWHHRQVVVEKLGDGSREIPFINQIIEEGSKNYHAWSYRQWVIQKFDLWKDELAYVEDNLRIDVRNNSAWNHRYFVVFSHPGHGVNQATIDREIEFAKKMIKIAPNNCSSWNYLLGVIRTTGYPVENLTPFLEDLKNGNIQSPYLLSTEIQVYEAVAKKENRSVDEKALEDISVSAGIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQ05</accession>
    <name>A0A8H7PQ05_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="1">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003203</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQ05"/>
    <dbReference type="OrthoDB" id="2441416at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006304">
        <property type="term" value="P:DNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011639">
        <property type="entry name" value="MethylTrfase_TaqI-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050953">
        <property type="entry name" value="N4_N6_ade-DNA_methylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33841:SF1">
        <property type="entry name" value="DNA METHYLTRANSFERASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33841">
        <property type="entry name" value="DNA METHYLTRANSFERASE YEEA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07669">
        <property type="entry name" value="Eco57I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00507">
        <property type="entry name" value="N12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Type II methyltransferase M.TaqI-like" evidence="6">
        <location>
            <begin position="406"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2177956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1092" mass="125918" checksum="7F4D039ED9332869" modified="2022-01-19" version="1">MQNSFIFHSRGLASDALTPASQNAAKRKLHAVIASDDCLTPFQAPFPNRIESPHCNNSTDTVRRMTKKAQSTLTINVPEKTSTTANVLPSPLSDNEPSTPTPLYARPQNQCASNDSKMESKFSSSTIVELLASEMMIVKEDIYRAMQEKLKVQSAENQNWSVSSKLAEFIHQQTHQQQEPGDLPHHRPVYASKEFLKSRDPDSHNALDFYCLLVAFITVYTSFLETSTSLIAANDHLSFLTSPLQAIMGTFHPVDNIFHHGSENLYLWYYLEQRELATGVNSTLQDQLFAHRFSAETAKHADIILSSFYTNHLLRIAAQKHQKDHGQFYTPASVVDFMWDTCMQNDGYWDRSVLAAQCPSVLDPCMGTGSFLSSYIQKIFRRIQLYSTLWSDADFLKEMMISMCSNIWGIEIDYFVLLLGKLNLMFHMFPACCRWMYINQRPIDFQLPRIQVFCNDILTLSLSTIDNSEDKAWEHQQVLKLRDPSALKLHFVVTNPPYMIRKTGFISIPDTSLYDMSLIGGRGTQAYMYFLWICLQRCHPLHGSLCFITPSQWILLEFAKNLRCWIWKNFVLQLVYQFEPYKIWPKIQTDSLIFLLRPRACTETTVPTTLFLRHMDRTKSLDQTLQDYRVFDESCCAKDSKITYKITPANPEIIFDVKDYSYAFLAPASNVVQRVQYLTRDLPRLCGTDNTHPNYQPPLSWKRGPNTNPVYALVIRTDWARSKFGESALQKWMRPAIYWNGKCDKNSRGQTKSKEILFWEDKDKQRLSQKENSPAEAYLPFRCPTADSHMGDQHYSMILIDNANTHELEDSNGQYQALYQYLKEAREKLQPTQTSRDIACCQFRQCGIEYPVKIVHPINFGYFSRTQPRQRFFLDTQRQCVTNQCMYFTIQPMAYVQDALFYLGVLNSTTIQFFIKIHCCYDQQGRTRFFARNMANIPFAPPSIPQQVEKMADMVRRMTNVRSFIYEIVKERRLKTAIEKLRQGRWDIECSKDCESFAHEDTSAMLPLSNGSTQPNLKRCPNKGLREYLRVAAYLQYGIDQLCYSLYEITADVQVAIESELAIQTCAPIEAAFPRQQAISLDCNGKLTTVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQ86</accession>
    <name>A0A8H7PQ86_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_007943</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQ86"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12398">
        <property type="entry name" value="RRM_CSTF2_RNA15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.70">
        <property type="entry name" value="Transcription termination and cleavage factor, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026896">
        <property type="entry name" value="CSTF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038192">
        <property type="entry name" value="CSTF_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14304">
        <property type="entry name" value="CSTF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="7"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="94"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="217"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2177286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="342" mass="37551" checksum="75927664A9E0D4E1" modified="2022-01-19" version="1">MAGRGSRVVFVGNIPFDCTEEQLIDVFKEAGPVESFRLVFDKESGKPKGYGFCEFQDAETASSAVRNLNGYELGGRQLRVDYADMDPAIEAQRQRERGGGGGGHENRRGPGPAQPPRAAPPPIQPSHVPNMPNMPPVQDSRSATDQISGTLASMNPQQLYTLMTQMKQLATDRPDYTRQFLNTNPQITYALFQAMVMMNIVDPNIITRILANAPQGNVPPQPAPPVNSIPNMPNVGQGAPFRPPPQKQMPFQQPEFNQPPPGLPQALPPMAGAPGKCGYVNYTMQRLHYANFLVATLDDLQQQQKALLMQVLQLSDAEISALPPGQQEQVRQLKQQILMSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQB7</accession>
    <name>A0A8H7PQB7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-xylosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_003102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQB7"/>
    <dbReference type="OrthoDB" id="2310373at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000852">
        <property type="entry name" value="Glyco_hydro_52"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03512">
        <property type="entry name" value="Glyco_hydro_52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00845">
        <property type="entry name" value="GLHYDRLASE52"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2177855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="711" mass="79003" checksum="188DFB12EC9C5AD4" modified="2022-01-19" version="1">MTKPIFFNAQHSPIGAFASFTLGERGPKGGFGHEIGKPADQNVYIGLENSEQEDVFDMLPFYGAPDGVLANYTPEEIAKQSKVTKTFSEGEIDRDYHPCIDTWHAGDLSFRITSPVKKIPDPAQASVAQLMDTLLPVVFVDITVDNTECDKPRKVCFGYGSTDSQKDFALHYLQHHHKDMNSLNGIGSGRNLAIVSCNGPKDPVHARVGFEIETLLTLKEEPTTSLGGCAVLVATVEPGVEKTLRFAVCFHRQGIVTSGMDASYFYTKWWKTVRDVASYAVENHERLVMEWQMPDTNLLIVKQLSANQNFQLTHAIHSYYGSTQLLQLEDGKPFWIVNEGEYRMINTLDLVVDHAFFELIMNPWTVRNNLEAFAETHSYYDQVSSPSNPKTLLDGGITFTHDMGVANHISPPQYSAYERPFLTDCFSYMSCEELTNWILTACMYISSTNDSDFVNHRLGLLKECLQSLVNRDHPDPKQRNGVMKLNSSRTQGGAEITTYDSLDTSLGQATENIYIAGKCWASYLALEKVLRDANATDEADLAATQAELCAQTMVASIDASSNLFPAIINTTTPHPARIIPAIEALVYPLFTGRKDALSFDGKFAAYLKALTQHLQSILQPGICLFEDGGWKLSSTSDNSWLSKIYLCQFVAREILKQSASDKADAAHVGWLTSPKNTYWAWSDQIIAGVALGSKYYPRGVTSILWCLEGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRN9</accession>
    <name>A0A8H7PRN9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRN9"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="125"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2179234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="168" mass="18422" checksum="376C146CA1ECDA46" modified="2022-01-19" version="1">MAPLAKYTRRQVHLLATAYNLKSKSLGSGNSRYPVLSKTDRTFIPQDRRYIERFISEAQSTLDEQGSILRKHRVSNNMSPGYPTKSKQKRGSGKKSSSSQNQSPNMGSATPHGYVVASDALPISDQNIGHQMLAAMGWRQGDSLGTEGTGITNPIQAIVRKKRMGLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PS40</accession>
    <name>A0A8H7PS40_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_001601</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COPE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PS40"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016478">
        <property type="entry name" value="Coatomer_esu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2178755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="36297" checksum="D439F544F0AEB24A" modified="2022-01-19" version="1">MDEDSVLFAVRNLFALGNYQIAINELSTSNRLLQSPEAQLEAKIYLYRSYVGQGKYNVVISDVADQDPAELQAIKLLAVYLQAKDKGNAAVVEQAVSSSTALLSDGANNVNPTIQLTSATILTNEGFQEEALKVLHIRGKSLECAALAIQIYIQMDRVDLARKEVANVKSWADDALLAQLLEAWVDLRIGGDKYQDAFYIFEEFAQSNTSATVKLLNNLAVSNLALGRYPEAESHLMEAVSKVKCRNMGNMLRMYNMHLNISLGELQDSNDADTLVNLIVCSNLTAKPADVVNRYVSQLREVAPQHAFLQDLDLKSSLFDRSAARYAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSL1</accession>
    <name>A0A8H7PSL1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSL1"/>
    <dbReference type="OrthoDB" id="2248195at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034098185" evidence="1">
        <location>
            <begin position="21"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="266" mass="30199" checksum="92C31FB385C7934C" modified="2022-01-19" version="1">MIKKLLYVFTFLLLNTLTLAAVYQAKVTTHIIQTNLQEYYENVLDEVLSSRGKDFLLSMGRMRPDRRGGVFETLQKEAGAFGVRDVHSSCLVKLPDLVQSHINQLHGYLLDAVEPSLQELYPKIVINVEEVDRDMSAVKTDGGSFANEELVSIVYSLNQAMGHYLGEQIDQYDIFTRISADMNQCNSHVPEPIKTDSLISKLKSWLFPENATGSHAFPKRESEQSSVTQRFLTSHLDVVRQDIWAEFDAQINDLIASITQDIWDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSX7</accession>
    <name>A0A8H7PSX7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPI-anchor transamidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003741</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSX7"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000003">
        <property type="entry name" value="GPI-anchor transamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500138">
        <property type="entry name" value="GPI8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034712357" description="GPI-anchor transamidase" evidence="6">
        <location>
            <begin position="29"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2179954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38885" checksum="64CA16F316F12367" modified="2022-01-19" version="1" fragment="single">MKSLRLRHLLVLFCSLATLTFFTPVILAETPNNADVVEGFFQQGGHTNNWAVLVCTSRFWFNYRHIANTLSMYRTVKRLGIPDSNIILMLGDDVACNPRNKFPATVFNNAARLLDLYGDNVEVDYRGYEVTVENFIRMLTGRVSADTPRSKRLLSDDRSNIFVYMTGHGGDEFLKFQDAEEISAFDLADAFRQMWEKRRYNEMLFMIDTCQANTMYSKIMSPNILATGSSELGESSYSHHPDWDIGVAVIDSYTYYNLEFLENIDMSSNKTLQDLFNSYDAEKIKSTPGIRSDLFRRPLDQVRVTDFFGSVQSVELTPTRYNLTAAENISSESYTDEVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PT27</accession>
    <name>A0A8H7PT27_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_003816</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PT27"/>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.100:FF:000001">
        <property type="entry name" value="40S ribosomal protein S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_eS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01168">
        <property type="entry name" value="RIBOSOMAL_S27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2180029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="217" mass="23820" checksum="54721FF9B821130E" modified="2022-01-19" version="1">MGFTSAMGTVAASWLLTKARAIHLIVVLFLIRAIMIGILLWYPVSSATIYSFSAIFGFCSLTIITMVTKYIGVVFGFRYLGTFSAIQFVGHQFGMFVGAYVGGLVYDALKSYTRMFYACFAVSIVGALASLFAKDLAVDLLNPSIETEKRQHKLKRLVQSPNSYFMDVKCPGCFNITTVFSHAQTVVLCSSCATVLCQPTGGRARLTEGCSFRRKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTS9</accession>
    <name>A0A8H7PTS9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_003996</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTS9"/>
    <dbReference type="OrthoDB" id="128536at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2180207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="162" mass="18247" checksum="8874A16CD9CF9991" modified="2022-01-19" version="1">MGRKSDPVAKAKNAIAENTQVYQRMNFLHQAAILLANIPKEATTAELAAKDHSTHPKSAVNSSRIDTTQEPALSPLSRHYCNTMKQISRKLVLRLDPNVKRSICKTCENILIPSVTSSTRVKSRPQKNITITCRSCNTKKRLVSKRGHELWTNKSKDKQVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUD2</accession>
    <name>A0A8H7PUD2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUD2"/>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2180028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="32689" checksum="AD12524C357AA644" modified="2022-01-19" version="1">MPKLFKLSGSEVLAIFAGSFTLLIGFGFRQTFGLFLLPITKDYEWDRTTFSVAAALLQIFWGLTQPFVVFTAERHLGFGRVLFVTNIVYGLGMIIMALVPKTMPGLFIFAMGIIVGLGTSGSGFSLIFATLGRRFPQGSKRHALVIGLVSSCASLGQGTCLPIIRIIIEQLGWKWTLIIQGCICIAIAPLAIFLRTVSQVPAELTQEDPASKDNLSLEELDGGDTEYGDDIESRNTGEETLISNEPQTIHAALKEAFSHTGFWLINICFAISGFHLGFIFTHLPAYVKNQGFDSTHEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PV87</accession>
    <name>A0A8H7PV87_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008781</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PV87"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000091">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="420"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2181199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="777" mass="89362" checksum="CD22D617781DD0E7" modified="2022-01-19" version="1">MAMSARRPKRKIQAPRKPPSSDPQLDKSFDLLAQAIHEIHRKNASILSFEELYRNAYSMVLQKRADTLYNGVKGVISEHLEHVAETEVVPAFVKTAGTDARASADAGTSFLMTLKRVWNDHTTSMLMIRDILMYMDKNHVKPANMPLVYDMGLELYRDKVIRSPKHPIQAQLTAVLLDQIKMERKGEQIDRSAIKAAVDMLVELYDNEQKENVYVVDFEPQYLETSSAFYLVESQALLAECDAPEYMRKIEKRMNEEYNRTRHYLSPVTESKIRNIVETQLITNHAKTIMEMENSGLRPMLAASAIDDLSRMYKLFSRVPEGLNEMRAYIKNYVLELGGLINAKVDNTTEAPKKEKDGGENEKPASNPSGSLYTALRWVQDILELQEKFDKIIEFAVLKDKSFQTAINEAFETFINENSRSPEYISLFIDENLKKGLKGKTEEEVDNILDHTITLFRFIREKDVFERYYKQHLARRLLFGRSVSDDAERSMITKLKVECGYQFTTKLEGMFNDIRISADTVIAYKDYLEASGMEKPKIDMSATILTSTFWPMSAATSPKWIMPPDITAACQSFEKFYYGRHNGRRLTWQPNMGTADIKANFNTKRHELNVSTYGMAILLLFNDVPEGNFLTASDIQSQTDVNDVDLKRTLQSLACGKYKVLIKDPKGKEVDSQDKFFLNVNFTCPLARIKIQTVATKVETETERKSTHEKVDKLRKHQIEAAIVRIMKDRKTMDHNLLIAEVVKQLSNRFNPSPQMIKKRIEELIDREYLERNAGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PV97</accession>
    <name>A0A8H7PV97_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Expansin-like EG45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PV97"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22514">
        <property type="entry name" value="EXPB1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034592610" description="Expansin-like EG45 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2181214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="27305" checksum="80283ED61899A490" modified="2022-01-19" version="1">MNFSGFLLLLLIWRTIAFKLPSSGTATITHYLLGDNVGACDCAIGANKYPVAAKSLISGTAINQNAFGVVNGTAGPGCGRCFQITLTSAISSQNYTISDPSKQPKVIVKVVDNCPALDPNLVNFTPGQLLIIEWCAQTDTQPNPHGAWVHFDISQTTIPSDFFPQPFGYDIGEWLSTYSEVSCEQWDGYNKPQTSGLQIADSGCCPANPTFDYQTCPMSGSSGAVTSMSSTVQFDVMLALIFCFISFITYFCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVB0</accession>
    <name>A0A8H7PVB0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_008537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVB0"/>
    <dbReference type="OrthoDB" id="2374950at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2180957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="128" mass="13891" checksum="3F8253A26DB3EA86" modified="2022-01-19" version="1">MLFTAIFAEHIVIDSPSNATTVAPGDVISVNYTVSPDAYAPIGSVRADLAAYDAKTILYPNITYAEWSDWHTQGGSVRGTWEVPEDLPSGWYHIIFKGVTGGHCTIPGTQKYRTCPGESTSSTMIYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWU8</accession>
    <name>A0A8H7PWU8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWU8"/>
    <dbReference type="OrthoDB" id="5405745at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024338">
        <property type="entry name" value="MID1/Yam8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142:SF1">
        <property type="entry name" value="AEL197CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142">
        <property type="entry name" value="MID1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12929">
        <property type="entry name" value="Mid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034931357" evidence="1">
        <location>
            <begin position="19"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="543" mass="59532" checksum="90A47D962A842807" modified="2022-01-19" version="1">MYIFWLHLLLLCPWSISAQSAVTVPLNNTQISSNTLALGGIQHYFFETSSIQNLLVPSATFTTPNTTNSTLAISEIISTLNVLSENPNSILRRAGSVLPIYLTVTVCSQPQPPPNYQGQVPPLQVFISTSSSNSLPGPSISGTSPVNNTHPGYIYWDSTASPSDQLWIGVSAPTLTQGWTGNWTYQLGASTTAPMHQLLVPNGVNDSIPYMTLDDTDNNNALFLTSSYQGSQAPNFTVMITSQVPTELSYSECAAQKLIQSHPVNYTVTSRGPFNATRQQAYVSGLSPATKYTAYYIQSRPNNLPSAYGPPIDVLTKSETNCRLVYGLSFCDQVAYSVVTSPNDPGADIWNLTASYDQNAQQIFQPFATALSQFNCDTTQYSLVRNCTDCYNDYKNWICSVLIPRCSSPSSFNQADANTNGPSQALREVPFNQSRNPWIDQTYSPNEWTELLPCIDLCYRVVQSCPPFMQFNCPYGDIALSQYGYWQAGSATQNGTNVTFDVNNPTCNRMGLNTSLLVLSKSPLSKPVWILITAMTISVSLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PX39</accession>
    <name>A0A8H7PX39_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008933</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PX39"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20024">
        <property type="entry name" value="FH_FOXJ2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000135">
        <property type="entry name" value="forkhead box protein G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045912">
        <property type="entry name" value="FOXJ2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078:SF2">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078">
        <property type="entry name" value="FORKHEAD BOX PROTEIN J2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="7">
        <location>
            <begin position="81"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="5">
        <location>
            <begin position="81"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2181350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="341" mass="38546" checksum="36E769500BB93DBF" modified="2022-01-19" version="1">MSTGYHSTYDSWVDRHHHHFDSSRFQQQQNELPPLSGPSSSFSTGILIPDAKRFSLPTPSPTSSSDRIKPTIKIEKNNAGKPPYSYAMLIRYAIETSPQRKMTLSEIYSWILERYPWFESAGTGWKNSIRHNLSLNKSFVRVPRPINEPGKGSYWTVDRRVDEGTAASRRRRSESYSHGRSMSMDAGSSIVKNQPHQQHQRSSSAAVAAAAAAAAAAATSRYRHSYDGYYQATPSHTADYSNMTNFDMYSCQPPPYGYGNDQFQYNMAYMPPQQQQQQQQQQQQQMTPTPSPTWPSQESGYPKMQAQAQHQQGSTPPTPNGDDEMTVDMDDRANWLQQVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PX72</accession>
    <name>A0A8H7PX72_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PX72"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2182022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="172" mass="19653" checksum="4F5EEA82926DC657" modified="2022-01-19" version="1">MLDVQLDYMAQTVCDIIPIVKPATSSSPIPELVYFIHKLTVRSHIDLRVAIVALIYLHRCKRVLPKGAVGNPGIYHVKLYDCDVKIIFLLNTAHRIFLASILVASKFSQETSLVPSAPLNNQRLCELCDGMYTLRDIGDLERSFLKIIKYRCWVSQEDIKKFLSRHRADLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PX81</accession>
    <name>A0A8H7PX81_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_006963</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PX81"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13983">
        <property type="entry name" value="STKc_WNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001565">
        <property type="entry name" value="WNK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050588">
        <property type="entry name" value="WNK_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13902">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="102"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="496"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="451"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2182037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="639" mass="72825" checksum="E037B549216924EF" modified="2022-01-19" version="1">MESSYQPYHTAKSDQSVDSGIHSPPQHDLLDQTMNSSAPNSEDGEYNNEDTTSSSILTRQLAAQYPDNYVSQYPSSSNDVIDRSSQHDTEKVVEVSPNGRYARLNTVLGKGAFKIVYKSIDRDEGYEIAWNVLQISRQEFKDLGHEIDILKSVRHPNIITFHDAWYNESEFIFITELMTSGTLREYIRKLQLPNTKIIKRWSRQILKGLAYLHSHEPPIIHRDLKCDNIFINGAHGEVKIGDLGTAQRTSPLLSTSKRYTVIGTPEFMAPEMYEEQGYSDKVDIYAFGMCLLEMATGEYPYTECKNAAQVFKKVTKNIKPDSLARVQNPEVLSLIQSCLASEDQRMSAQEILEHSFLAVEPEVVLLATDATKKQLTLQVVFKGMDRLSVKFEFNGDTDTAEEVVNEMIEEQVLPHRYQQLITNEINRILREMNKEPDDENKEEDRMVWRRENDIRSELERARQELVSASDRAHEAERRCMTFEQRVKLAEERYQDVMDRRESEPSETHAESAPPVGTTAPTLNSPPFPVSLSHLSLSDDDRIPESSTGRTSHSALMAHILSEYSDDTSIEKFVNDTAIATNRERKSAEWAAKLRAQDIMTVGDLRGLHDEDWSGIGLTVFALRALKNMLRHSKKRPDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXQ1</accession>
    <name>A0A8H7PXQ1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_007134</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LAMTOR5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXQ1"/>
    <dbReference type="OrthoDB" id="76862at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024135">
        <property type="entry name" value="LAMTOR5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13342">
        <property type="entry name" value="RAGULATOR COMPLEX PROTEIN LAMTOR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13342:SF2">
        <property type="entry name" value="RAGULATOR COMPLEX PROTEIN LAMTOR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16672">
        <property type="entry name" value="LAMTOR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2182207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="95" mass="10091" checksum="248726A70AA279D0" modified="2022-01-19" version="1">MLFICGTDNKLEFRSDQEGVKGVLLVDESGLCLGARGIAKSAGAGFIASIAHSAKSLGDVSEIEDKSQYPTVSIELDNLKIIVRNEGSFTIAVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXU9</accession>
    <name>A0A8H7PXU9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">INT43_008708</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2</text>
            <dbReference type="Rhea" id="RHEA:38959"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heteropentamer composed of five different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXU9"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="UniPathway" id="UPA00661"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000018">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000013">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000015">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF352">
        <property type="entry name" value="ACYL-COENZYME A OXIDASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 15" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="19">
        <location>
            <begin position="41"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="18">
        <location>
            <begin position="170"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="20">
        <location>
            <begin position="310"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="17">
        <location>
            <begin position="522"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="697"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG2181126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="723" mass="81403" checksum="4DE31173AB12AAA7" modified="2022-01-19" version="1">MSSAKERVQAVKQHLSPEQERAIAVSPVESMKAERAKAAFNIRDMTYLLDGGKSATETRERMMLELERDLVFRMYDFHDLTKDELRERTMEKVRIGSENFRNLLNHLTNESVNTFRKRMEVVSLIDPGFWTRFGVHYGLFFGALQGSATPGQFSHWASKGAVSLNGMIGCFAMTEMGHGSNVAGVETTATFDEASDQFVIHTPTITATKWWIGGAAHTATHAVVFAQLIVGGKRYGVKSFVVPLRDPTDYSLLPGINIGDIGKKMGRDGIDNGYITFTNVRIPRGYMLMKHTKVSRTGQVKEPKLQQLTYGALLQGRVAMVVDSGNVAKKALTIAIRYAAVRRQFATKANEGIETKLLDYPIHQRRLMPLLAQAFAMHFTGTEMNTMYLQLMDRLESAGPDDDDLPEVLENLKETHATSAGLKAFCTWNCLNTIEQCRQACGGHGYSAYTGLAGMYQDFAVQCTWEGDNTILTLQAGRYLISSYREAQEGKKLAAGVSYLNRLNELIGKKCSVSKVEDVATLDVIAEAWDVVCANVVQHAGKEFEECIKSGMEIDEAYEQCSQSRLYAAKLHSYGYLFKRFADGICKTPEELRKILLPVCLLYGLYTVEDNAGAFLQYEYFSPEQISYIRTKVNELCKTVRDQAIPLVDSFNYSDYIINSPLGRKDGNVYEHYFNQVKQQNPPREHPYFDRLIKPFIHRKQDEDDLDDEEEEGGLESEDEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYQ5</accession>
    <name>A0A8H7PYQ5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphatidylinositol N-acetylglucosaminyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_007280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYQ5"/>
    <dbReference type="OrthoDB" id="196709at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016104">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2182350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="34603" checksum="F7DB0E13C800A043" modified="2022-01-19" version="1">MRLNGNEVNKLPWRKLLYVIQDYPDNYVDDTFLDELQKNVNVRSYDYWTTVYESGVIVQHISSIVIFIAVFIHLEQQKLATNTLIIIGTLMTALGYVFWDYSVVQLVPSYAFKRKKTAKGALFFFATLLGLSPILRTLTLKTSDDSIYAFTVCLFIVNMLSHDYSAGNRHTIKFPGSLSTNAAIFASVMLASRLQTNMGVFGLTAFAVEWFALFPIFRRHLQNTTQVGHLALSVIMLSTSIALYIEISKAVAFLYILGISFITFVCPAWLIRIQKYKNEIHGPWDEAQPKLQRNREKHMKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYT8</accession>
    <name>A0A8H7PYT8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_006864</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYT8"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034552801" description="SH3 domain-containing protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="221"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="45"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2181939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="323" mass="33947" checksum="A68D92ADC34F2FFF" modified="2022-01-19" version="1">MAAIALASLCIAAVVEAAPNIQPMEHYQALNKREETTIKAESSTKKAATTTKKATTTKKATTTKKATTTHAASSAHPASSSKPVSASIAPSGAVSSGVASQSVPLGIYPSTGVNPSATSVISPTPSSDASQSSSGLSSGAVGGIAVAAVAVVGVGAFAFFRYRRKNNPSAPPSNYPRTMRQSMAEPFSMGFVGASKPQQQMPSQDNPFPPATPYERLEEPKSLGVYDVVSTYTPTLGDEIDIRLGDRIRVLVEYDDGWMLGENLSNNDAKGVFPRHCIDYPGNENYAQPAYTADQTSEATLQVNGDNRRSKRVSSLYSAGDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZC1</accession>
    <name>A0A8H7PZC1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase Rpb4/RPC9 core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_006226</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZC1"/>
    <dbReference type="OrthoDB" id="2186918at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030880">
        <property type="term" value="C:RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="4">
        <location>
            <begin position="18"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2183222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="146" mass="17161" checksum="D283EFE15DACC75A" modified="2022-01-19" version="1">MTFDTVYILPSYFDLQLTEFQTAHCLFISELRILLEAQRESKERNAENRPQTNVLQKTMNYVQSFSRFTNMESVREVRSLLKESELSHFEIAQLANLCCDDAEEAKALIPRNTNKLVMEHSLHNKIDDDRLQELMNQMLTIKKFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZG6</accession>
    <name>A0A8H7PZG6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RmlD-like substrate binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZG6"/>
    <dbReference type="OrthoDB" id="6235964at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048269">
        <property type="term" value="C:methionine adenosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048270">
        <property type="term" value="F:methionine adenosyltransferase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05254">
        <property type="entry name" value="dTDP_HR_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000357">
        <property type="entry name" value="Methionine adenosyltransferase 2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="DTDP-4-DEHYDRORHAMNOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491:SF4">
        <property type="entry name" value="METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD-like substrate binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2182520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="299" mass="33287" checksum="BEC8AE873D8A2D0D" modified="2022-01-19" version="1">MKVLITGASGLLGRAVYQQFKKNGHEVVGTAYSRATNELHKLGLTEESDVREFVEAHKPDAIIHCAAERRPDVAEKDRAGTEFLNIQVPKNLGKLTKEKSIFLIYISTDYVFDGTQPPYDAIEGKPNPLNFYGKTKLAGEHAIQEVNQDAIIVRLPILYGNTEFNGESAVNLLVDSVLDQSKPAKMDNVAIRYPTNVEDVARVLADLTSAKLEQNKDISGVYHFSGQKPYTKYDMCEVFAKAYHIPMDHVQAVDTSSDPGAASRPKDSHLSNSRLEQAGINTYNVDFEAWWNKRIKASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZJ5</accession>
    <name>A0A8H7PZJ5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_007496</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZJ5"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15502">
        <property type="entry name" value="PHD_Phf1p_Phf2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12628:SF10">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12628">
        <property type="entry name" value="POLYCOMB-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="193"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="H15" evidence="12">
        <location>
            <begin position="337"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="406"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="450"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="499"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="573"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2182565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="642" mass="73576" checksum="4D6261E96DD20841" modified="2022-01-19" version="1">MANQPHSPLSIAALTDQHSSYAPPRPPSDTTRSPPTTYSTQPSFRNSPLIGSPNDRISVSTAPNARSGEDAFSEPPDENMAGNEENSNTYREIDEPSPGSPSSGEFNVSMKSGCRLSQITPPSGCDLRLQSPPTNSADDESDQEYDKIEQRTKYGRTINKPEHYVSIQPISSGRKSQKRRTSTTSGFAGNTQRIFCTLCHRGNSPQHNRIVLCDRCDRPFHQQCHMPPIESITLEIEGTTWFCNQCETEREHRLNVKYEIDGRDIEKEAKMAYLLSLPKSFLMDMIFTYERNHPGLRLYPAMLKSERSRRDSLSISPPARAEMMDTNDDEAGYNLDDVPSYEDMIEKALIAIGDPRGSSPRSIWEWMGRNYPLAEAFPRSASQSLQKAVKKGRFFKEGSCYKINPNYIPEPKSRRGARKPSFIGKDGTMIRPSKRTKIQLNDAPAVETRYNNSYFPSSRSASTSQYNSANQARRLASPLEADEKYRSPIESDNGSPWRQPEKYNRIDRTTRDIEELNIREQSQSERSRDWSPWQKHDDSERYHREPESKRDWYSNRDTHGYESGHNEPRKPWNSWQSESQSKPTEWLSQRREIPSNPTSPRHSSSLPPLAHVYPQESQEGDQERRQSQYSPSRWEYRAQART</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZW0</accession>
    <name>A0A8H7PZW0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZW0"/>
    <dbReference type="OrthoDB" id="5553410at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="entry name" value="PNP-oxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019595">
        <property type="entry name" value="DUF2470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028110">
        <property type="entry name" value="TMEM254"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10615">
        <property type="entry name" value="DUF2470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14934">
        <property type="entry name" value="TMEM254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2470" evidence="2">
        <location>
            <begin position="11"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2183206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="246" mass="26960" checksum="19AC5407BFE4C0B6" modified="2022-01-19" version="1">MVNQDPIAPHSAGISAYMSVHSATNLAYVRYFANQERAVSATFKSINASGFTVEYELIDGSKHDAFITFETPLTKREQIRPVLEAMAKEAEEALGMPSSLAGPPPIAAIAKSIYATATDAYTPPTSDVPLDTFYYPNGGLIVAITMGMGILYYYKGLSQAQANELPPALRQLYRVIPAHWYRPLWNVAAGLHVAEAVVAFGTCIHRGWYSTGNVLKWTISTGLFGFASMKKLRLHGRQVREGIKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q007</accession>
    <name>A0A8H7Q007_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal lysine N-methyltransferase 4</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_006399</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q007"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19178">
        <property type="entry name" value="SET_SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1410.10:FF:000007">
        <property type="entry name" value="Ribosomal lysine N-methyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011383">
        <property type="entry name" value="N-lys_methylase_SETD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044430">
        <property type="entry name" value="SETD6_SET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011771">
        <property type="entry name" value="RMS1_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="24"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="192"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2183393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="449" mass="51029" checksum="CF8E607F2F08D824" modified="2022-01-19" version="1">MSEFDKASDTFVTWLKYNGATVADSVAIKDLRSQNAGRGMVAVKDIKEGDLLFSLPRKILLSEETSELANIPDVKEKLQQLDGWSPLILCMMYESQREQSFWKPYFDILPKEFSTPMFWDQKDLKELAGTSVIDKIGKEDAETLYNETLLPIIKSHPGVFDEKVHNVDLFHVCGSLIMAYSFHDELAVRKRQENDEKDNLDEAEAEAEAEDEDEDSDEEEEEEQGIIAMVPMADMLNHRTGFNNARLFHEPEALQMRAIKDIKAQDQIYNTYGDLCNGDLLRKYGFVDEPNEHDIVEISGDLVLNEGCPKGSSEKEKEAKVTFLLEEEALDDCFVIESNGDVPPELLVCVQVFMMSSQEFSTMLGKRKLPKPKRSAVIMDKIIAILTKRLEQYSGSVEEDEKRLRDSSLSLNQHNSLIVKIGEQLILQKALNQAQAADEHGPKRKKLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q055</accession>
    <name>A0A8H7Q055_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sds3-like-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_006518</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q055"/>
    <dbReference type="OrthoDB" id="70376at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="263"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2183512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="45566" checksum="4599BC4F59646D1B" modified="2022-01-19" version="1">MLPQTSHQYSLPPITSQVYGHNSRSQYEYAPPPMHAGHSPLPHLSNLAFRPEDEQTYGDHQPPPRPGYPGPQYMYGHGAYGSPHMSNPPSYHPMSPKGHDYPPAAAGGAGSYNPVTAKGYDKAYSDPYKHHVEEQADAYSGRWPKETEQEPVYRNGYKPYYRDTYGDEDNDWSEGEAMDVAENSRDRRKREYTDRVVNINSDFMDSYEMIYQEKFGALQEDLLAVQQETHPALRESISDLEKARQKVIKKARFIMEYHVECTNEQFQAEIAGLEEEYMAEKQGMRDMMLNALEEKRKRLREEKDNENDIANDIFFSTHQTRNRKRILRKRGGIIETESLTHYRSPNSVIRLNTLANLNTALTNRDEDELDQDLVIIRKATSTNRRTVPAVTKAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q088</accession>
    <name>A0A8H7Q088_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rad50/SbcC-type AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_006713</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q088"/>
    <dbReference type="OrthoDB" id="18797at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="10">
        <location>
            <begin position="15"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2183702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="116" mass="12591" checksum="8D18E3630DC6F47C" modified="2022-01-19" version="1" fragment="single">TNTSLNSGTMSSVDKLLIRGIRSFEPEEPNVIQFYSPLTLIVGSNGSGKTTIIECLKYACTGDLPPNSKGGAFVHDTKVNGNISVRKLCEEHGRLNLNDSPFFSCAAKRKSRLRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1S9</accession>
    <name>A0A8H7Q1S9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD40 repeat-containing protein SMU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_006789</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat SMU1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1S9"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045184">
        <property type="entry name" value="SMU1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054532">
        <property type="entry name" value="TPL_SMU1_LisH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17814">
        <property type="entry name" value="LisH_TPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="10">
        <location>
            <begin position="40"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="211"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="261"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="304"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="346"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2183778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="525" mass="57430" checksum="6EF7F562A64367A0" modified="2022-01-19" version="1">MSLEIESADVIRLIEQFLKENNLSRTLAALQEESSISLNTVENVDTFKQDIIDGNWDTVLTTVLNASVPAKQLGDLYEQIFLELLEMRELGAARSILRQTEPMQILKSRSPERFLRLEHLVSRTYFDAKEAYPDGTTKEKKRQAIAKALASEVSTVEPARLLTLLGQSLKWQQQQGLVQPDAAFDLFRGQTQVVKAEDDAVPSKQYSMIKFPGKKTYAECAAFSPDGQLLATGSVDGFVEIWNYLTGKLRKDLKYQAEENLIAMDNSVISLAFSKDSQLLATGSTDGIIAVWKITNGQCQRRFSPAHSQGVTSMCFNKDGSQVLSSSFDHSIKIHGLKSGKVLKEFRGHTSFVNSITFSSDMSRVISASSDGTVKIWDTKSTTCLATISPQAQANVPNGSLNPIGGASGQTVNSVTIMPNNSDNILVCSKTSTLYLINMRGQILKSFTHEKKGGADFVSASVSPHGDFAYAVAEDSTLYAFNTSNEALINEFKLTEAEVIGIAAHPYSNILAAYAENGQVLLCKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1U3</accession>
    <name>A0A8H7Q1U3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">INT43_006761</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1U3"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18659">
        <property type="entry name" value="CD2_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000005">
        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF14">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="14">
        <location>
            <begin position="129"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="14">
        <location>
            <begin position="229"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="327"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="624"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="906"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2183750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1050" mass="120922" checksum="D469FF6BC4025F11" modified="2022-01-19" version="1" fragment="single">MEGSAKKKKKTNRAKPSQRGISTKRSRGRTPDDLVSDAMSGASSSSDDDSDGEWNQPSKKKKKTKRSHRKKVPKSEDIPTAVDAVRFSTRQRPQMQYNEEEYDMYGLGSEDEDMLTPASQPIVEEDEGDVIEAVLDHRRRYGTETGIADIPEKNLEFLVKWKGYAHIHNTWSDYDYLLDFKGIRKLENYIRNSVLEDRAFRRNPETTMEDIELRDINIERHRQEIAAWTQVERIISMRGTPPDSEYLCKWKSLHYDECTWESYELVSSDFQDQVDAFLDREQSQRIPSKSAALIKNRPAFAVLRDQPAFVTGGELRDYQLHGVSWLYWLWCTNSNGILADEMGLGKTIQTITFLNLLFNKHDFYGPFLLVVPLSTLDNWMNELAQWAPELNAICYIGNQKARQTVRDYEFFQPNSKRLKVNVVITTYEIALKDRNELGQVKWQYLAVDEAHRLKNADSQLYEALLEFKTTNRLLITGTPLQNSVKELLALVRFLNPEMITSELEIDLSKPDEDQEAKIKLLHEKLNKIMLRRLKKDVEKSLPNKTERLLRVEMSPMQTHYYKNILTKNYAALSGSADKKQWLNIAMELRKASNHPYLFPEAERRTDDREEQLKGVIGNSGKMVLLDKLLARLKEGGHRVLIFSQLVMILDILSDYMVMRGHSHQRLDGSMNQADRNKAIEHFNAPDSPDFVFLLSTRAGGMGINLTSADTVIIFDSDWNPQNDLQAMSRAHRIGQTKSVNVYRFITKGTMEEDLIERAKRKMVLEYCIIKQMDTSGMSHLDANNLLTTSTGKPRDMPFDKNELSAILKFGAQNLFQATKEPPKLDDLDLDDILARAEHTETMESEGGQTLGDQEFLAQFQVADFGSAEEQLSWEDIIPEDERKAAEEERQIKAEMELFDRAARKRMRRYTEHDDQEASGPKKQPTQRKRRKAPQTANGLSKKQLTFIVNVVKKFGDISDKLERILSDGDTLNMEPDVILEKCQDLLQTCKTASLKATTKANESLLVEWNDIKNINATQINDRVEQFELLDRRLGQLAKPEKFRFSATIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q206</accession>
    <name>A0A8H7Q206_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol phosphate-mannose biosynthesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_000575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q206"/>
    <dbReference type="OrthoDB" id="311279at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180047">
        <property type="term" value="P:dolichol phosphate mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009914">
        <property type="entry name" value="DPM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039:SF11">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07297">
        <property type="entry name" value="DPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2184662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="85" mass="9376" checksum="32D8C52C34A78504" modified="2022-01-19" version="1">MANGKDKAVGAAAFSVAVSVFVYYTTWVLIMPFVDADHPLHGYFPANEYRIRIPLLILVVGLTVICSFLALVMIKSKSKKTKKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2E6</accession>
    <name>A0A8H7Q2E6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2E6"/>
    <dbReference type="OrthoDB" id="20035at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2183436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="203" mass="23574" checksum="E9FDDB8338D95200" modified="2022-01-19" version="1">MHDEYILPPKSLHPFNNTSDDTFSKMLEIKNPRNRSLTSQSSTTVDGFSNFLATAIEKAILKNLLLPEDIKSYDPVVIVTLPRLALLIAMIDCDWRNMLWQHDERWIRTKREEEEAFASGKHWFRHREIQLQQLASQCQSIQDNVRTDLEQSLIRGQGGEIFKHICSLSDALISSRNFCKLLQSTIDDWKTKQTEEELDSLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2V4</accession>
    <name>A0A8H7Q2V4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E2F-associated phosphoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_000821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2V4"/>
    <dbReference type="OrthoDB" id="122464at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019370">
        <property type="entry name" value="E2F-assoc_phosphoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15967">
        <property type="entry name" value="E2F-ASSOCIATED PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15967:SF0">
        <property type="entry name" value="E2F-ASSOCIATED PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10238">
        <property type="entry name" value="Eapp_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2184908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="25231" checksum="B77066B97B6A1306" modified="2022-01-19" version="1" fragment="single">AGKVDSACLGESQTILNLQLTVTSYFFLGCQYFFDMTTTDSASGSTKKQYYDNDYFDTDEEISDNETSMAVDDSENKDRRKLREIQSNDDLLYDPEDDDANEDWVGEQLRAIAPSKNGTPSKQMAKTDAILTCPLCFTPVCLSCQRHELYPNQYRAMFVTNCRPNFAERFRYRESNNANNIPEEAKGKDVYYPVNCDICKTHIAMFDDEEVYHFFNVIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q310</accession>
    <name>A0A8H7Q310_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_006747</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat WDR3/UTP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q310"/>
    <dbReference type="OrthoDB" id="407922at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000157">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000178">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25173">
        <property type="entry name" value="Beta-prop_WDR3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25172">
        <property type="entry name" value="Beta-prop_WDR3_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="419"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="500"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="601"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="643"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="685"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="8">
        <location>
            <begin position="818"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="928"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="944"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2183736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="953" mass="107789" checksum="85CDA5E69EBE3745" modified="2022-01-19" version="1">MVKAYLRYEPSQTFGVINSTGSNIIYDHEGKLAIAPALEEVIVWDIKKGTQIGKWKDSSNRAEVTCIARSPNNYDFAVGYQDGNIRIWNIKTSTSTVTLNGHRGAVTALSFDSDGTRLVSGSKDTDIIIWDVVAEVGQYRLKGHKDQITQLAFIERDLNKDTEDEMSTEENIGVSRSGYVLSSSKDTLLKLWDLSTQHCRETVVGHRTEVWSFDINGKKDIIISGSSEQVLKVWKIDWSVLAQSLEQLDAEEQQVEEGDAMDGVEHQAPTLKKAINLYGNLPRSSRDRVITVQFHPSQEYIGVQAADKSVELYRVREHDEIRKKMQRRKRRQKEKGKEVDDTDEIQVEDEFTPHVIVRTPVKVRSFDFAPVTDVKKAGQIQFVASLINNTIDVYSAPLPVKKASNEEQPEPVRLHSLDLQGHRGDIRALALSTDDELLASASNNILKIWNVKSTTCIRSLECGFALCSAFLPGNRHVIVGTKTGELELYDLASSSMLESIKAHDGAIYSLQVRPDKRGLVTGSADKDVKFWDFDMVEDKSVDGNAQTRPKRLTLAHMRTLKMSDEVLCVKYSPDQNLVAVSLLDTTVKVFYHDTLKFFLSLYGHKLPVLSMDISSDSTLIATCSADKNVKLWGLDFGDCHKSIFAHQESIMAIQFVWGTHYFFTASKDKTVKYWDGDKFENIMKLEGHHGEVWSLAISKHGTFVISGSHDRSLRLWERTEEQLFLEEEREKELDELYESTLAGQMEKTDINEGDELGSAGKQTMETLKAGEKIIEALDLGDEDQAALAAYHKAKSQNLPASMPQRNPILIAMGDLPADKYVLQVVGKVRANDLEEALLVLPFSKVVSLINYLDQWAKKDWNIVLVCRILFALLKTHHHQIVANRMMRPMLDSIRFNLRSQLQKHKDTMGYNRAALMYMQRDYKSKHMTEFQDEDGPSTEDGQEKKRKFVNVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q335</accession>
    <name>A0A8H7Q335_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin cytoskeleton-regulatory complex protein SLA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_000844</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q335"/>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.700">
        <property type="entry name" value="SLA1 homology domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056996">
        <property type="entry name" value="PH_SLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007131">
        <property type="entry name" value="SHD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF81">
        <property type="entry name" value="ENDOPHILIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24081">
        <property type="entry name" value="PH_SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03983">
        <property type="entry name" value="SHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="67"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="292"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="360"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="525"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="618"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1017"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="362"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="626"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="764"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1017"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2184931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1128" mass="127210" checksum="D1705F73AAF6BC23" modified="2022-01-19" version="1">MKYVAVCKALYDYDAQESEEVSMKEGDVVYVVDNSDPSWLEVQLKMPSVNQIGPVGLVPANYVEEVQPIGTVRADYAYEAQQDEEVSFEEDEVMTLYEKDDADWYLVQLNSGIIGLAPSNYTKEVDSHEVQQHRNKRHVEEQVSEPLQPASLPMPLANSSSAVTDDAKTWSVQEYNPEKKKKKKGKGTLTVGNSMIAYESETDKSAPLQQYHVLDISKYLLDNKNVHIEISNERPTILDFQAASKSEAKAILVKITDSRTAAAKFENSQRPESTQNEPAVTDSADVPQSFSCEPKWGIVLYSFDADGGNELSVREHDQVLITDYSSSEEWWHIETSDQRSGIVPSSYLQFHEDYEAALAKENGQDEENKRQQMEARRKAEQETEKRKADERRRKQREEEEAAREYEEAKRAEEANRRRQDEERRKQEEERRRQEEGRRKQEEERQREIERKKKAERAASKQEVSLPNPAKVRWWTDRSGAFRVEAQFLSASGGKYRLHKVNGVKIDVPEDKLCIADVEFVRNLLSKQRGEKSQPKPSSSNPSSSSKATAPPSKQYNQDWDWFDWFMMIGIPMQQALVYSSAFKSDKLDDSDLPKLTHKQMKTLGLKENHVRRIERFIENEHVEPASGDENDNDEEDEQLARRVKEAETSGTAPNIFRRKSKSSDSSGVSRPTPATSAPSKVQGDIFDLLTGEPVAEEPELQPASPDVTGNSFVAATSPVKEVTSPKGSQDGFDDDAWIPRTVQAIKTGTYKPKNPPLVQQPAPTSGSQQSMSGQLSTQMTNSTGQSQNYQPQQQQQQQQQQQQQQQQQQQQPQQQPQPQQQPQQTVFQQPQPVQQQQSGFQQPVQQSFTGYQQQHNQGVNAPQLTGVQQPIGLQQPVGLQQEYQQPQSTAQFAQYATQGTGPQQQYQQPNMQQFAPQSASNMQFQHQQNTGVPVQTQFIPQQPTNLQYQQQQPHMAMSNPSQFVPQQMTGMQFQQQQQMPMQNQQPIQQNFSQPIQTATVPLSNILPPPLVPQSTNSFGGGVQPQQTGSRSWQTATAQNPFGSPTPAPLAPQLTGVQFSTPSPETFAGNHHMNAISPQYTGMNGQQSGFGNTFNGNMNNRGFGQPNVFQQPYTTTNGFNQPNSFGQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q492</accession>
    <name>A0A8H7Q492_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor SYF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pre-mRNA-splicing factor syf1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_000687</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q492"/>
    <dbReference type="OrthoDB" id="10067343at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000023">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000137">
        <property type="entry name" value="Pre-mRNA-splicing factor syf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000038">
        <property type="entry name" value="Putative pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="14">
        <location>
            <begin position="25"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="12">
        <location>
            <begin position="186"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="13">
        <location>
            <begin position="397"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2184774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="763" mass="89581" checksum="0C0540DE7CC5BE37" modified="2022-01-19" version="1">MPTVAKSTALRDASHFQDTLLITDDDVPYEEEILRNPQTLRCWLRYIEHKKNGPKNQLFLVYERCLMQLPGSYKIWKRYLDLRRAQLNGLNPIDHAEQFEAVSECYERALVLLNKMPRIWLDYCTFLTKQPCITKTRRTFDKSLRSLPLTQHERVWSLYLEFAKEISGETANRLYKRYLKLDPSHIEVYIDHLLALEHYDEAATKLASVVNDDKFKSIRGKSHYQLWQDLCDLVVKHSEEIKTLKVEAIIRSGIRRFTDQVGMLYCLLAMYWIKLGLLDKARDVYEEGITTVMTVRDFTAVFDAYAEFEEEVITGKMEMAAEREERGEVDKDEDLDLDMRLLRFERLMDRRPFLVNDVLLRQNPNNVLEWEKRASLWKDNKEKVVETYTDAVQTINPRKAPGKFHTLWINFAKFYEKGGDMESARAIFEKAAKVPFANVNDLAELWCEYAEMETRHEEFDNALDVMGRATTTPRFTHVNPQNVSYHDESLTPQQRVFKSLKLWSFYVDLEESVGTVESTKAVYDKIMDLRIANPQIIVNYATFLEENEYFEDSFKVYERGIDLFGWPIAFELWNIYLERFLRRYGGTKLERTRDLFEKALDGCPAKYAKPLYLMYGKLEEEHGLARHAMRIYDRATRAVSDEDRLEMFNFYIAKATANFGVTAAREIYEKAIEALPDANARAMCIKFAELETKLGEIDRARGIYGYASQFSDPRSVEAFWQKWHDFEVKHGNEDTFKEMLRIKRSVGYSVYAHNPVSAEIKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5M5</accession>
    <name>A0A8H7Q5M5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_002689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5M5"/>
    <dbReference type="OrthoDB" id="2337740at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2186251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="22943" checksum="121B7FB1887F95E8" modified="2022-01-19" version="1">MSALQNSNSELNVLEQSPLVDQSFSTKLHVPATDFAEECPVTLSMPTDQWENWKTDQERKFACKFHDQTPKYTYRRKTNGTGGRPATNIFYRVFRCHRRGHYQSQAKQRKAATSIRCGCEAMFTVTCKKSSPDMVQIKYHWRHTGHQPGTPSDLAKTPIDKEAREWIRQRVEEGMDWRGIKQLLKTEQEIMFKVWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5V7</accession>
    <name>A0A8H7Q5V7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alanine--glyoxylate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_002318</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.44" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5V7"/>
    <dbReference type="OrthoDB" id="7403325at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004760">
        <property type="term" value="F:L-serine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019265">
        <property type="term" value="P:glycine biosynthetic process, by transamination of glyoxylate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000049">
        <property type="entry name" value="Alanine-glyoxylate aminotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000027">
        <property type="entry name" value="Serine--pyruvate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF24">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="9">
        <location>
            <begin position="42"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2185880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="379" mass="41299" checksum="48AC463FACFB2790" modified="2022-01-19" version="1">MSQPHKLCMIPGPIEFHEDVLDAMSTPATSHVDPLFVPIFGECIELLRKVLLTKDAQPFIVAGSGTLGWDMMVNLVERDDEVLVLNTGYFGDKFAECLEVYGAKVTHLRAPIGDRPSLDELKKALSAKKYKMVTVTHVDTSTGVLSDVKGVAETVKSISPETLVVVDGVCSVGSEEIRFDEWKLDAVITASQKALGVPPGLCIVAVSQQALQVFKTRKTPVAGYYSNWNKWLPIMTAYEARKPAYFATPAVQLIYALLASLKQLTAQSMDTRFDQHRQVSQKFKKAVTDLGLKQLAVSDEVAANGMTAIWLPEGVQVSDIVPSLAAKGVQIAGGLHAECATKYFRIGHMGISVTEPQRGHIDKVIESLTTTLKEVKSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q631</accession>
    <name>A0A8H7Q631_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_002154</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039930">
        <property type="entry name" value="RALGAPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046859">
        <property type="entry name" value="RGPA/RALGAPB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21344">
        <property type="entry name" value="RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21344:SF1">
        <property type="entry name" value="RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20412">
        <property type="entry name" value="RALGAPB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="1058"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="725"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="994"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="750"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2185719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1318" mass="148107" checksum="5AACB3A8F88217E2" modified="2022-01-19" version="1">MFLDWIAQLHLLQHDAQTNILNVLPVSTRRTLIAEITSYLHPAAGKPPPPPSIFSSPAHVKWFMEVIGQGFNLPLEDMAITSEDINIYAQWLFEANQRPTAVSREGLEQEFFQIIFHQYSLLFRPRVPRQSSGSKSSVYTTSAIIPAPGATSLMAVPMTQPNPGTTKEAAAQLIQRHIELCKKVLTVFTMAGRTLDLSEETWSVLLKVVLGITDSLLSERPNADNHRAGQSMGDELCEHLLRVLFELWLRSKTRDVEMWDIMKRCFVRWTHRPKAIQQWSSIALSLTNRTLRFLYGPTAGSPMVSLVVNGFNVKLDLPQDFVYYAWHRMLFLIPNPWQLSPGNFALAIMGVGKIVEAFHSVGQSSTPVADSLSQPDGNTLLHIFGGWLFDACFSAPQLSTEYQQGRAEAYGILCRIFSKPQSREPFLRLYIERFYAALAIGLRSETCLPTILTSSTELFATDLEGVRLMVPDFVVGIKSILPNMQPEFRNVVVSVDELRLAAIKVTSTIMSLPNHFENVTLKADWDRGLNVASDSPTMAGEQEKLVSQLMKVLYAQQSSTQPAFTSLKYYILELLLMSLRTETSSYNMRYLLHLINVYVVEDVPFCPGLVGTVVKLIQEKILTMQLGSDVTLVAFDVLMDFVGLYEYVKRDSKNVARELVLALCRYADTLISTGNLAHKYPLVVQAYDCMMRWVMVGQWIVDDRDCQHAVVATLSKGITIFEREPEIASQGDGSQEKKKRRDNAFPPTKQLFQLPNRANKSGSGSQITDAEKSASTQNRNGIGMHKKEEVAVKMAAEYCMSQFVNQLGNFPPWKDQVGPTRTSTLLDDLEILKSWKQKRDHGDNEENIVEPIRFFLLDGRVVIGLMDIKDDGNEDDTTDLSKSPALVLICRDTTGKYSWTSHLRYEDLINKLSPSTSRSLSTSSSIVQVNLSPYTQNNSGSNLDASVSASKSNTSIPTAEAVNWMALPSLEQLLQEKPDRKAEVEQLKIITATQQSAEEESQLENSRVIPKVSPDSGDTNIDKRPGHRLFMSHLGFLNNKNRSNIVPLKTTDSLISELETLDLLNERDCISISTYFAQSGNATEAELVEQPAGMKEDYLRFLYTLGWPVKLSEHNGYRGKLDTGVCDVIPYFADRMVEVIFHSPYFLHAPHQDDLTWGSMPRISKLHQQITLDDHVCIIWIEDMTNWESLVHRIKGMSAPNAKSMVYIFINPLAGAVDGLYWIRIMIPSLGNHPAACQRLKDNALIVGPLVDGMIVSRHALGAMVRNTAISAHQACRVVTDSFTRPYVIRKHFIEELAHRHSAKMSLSKFYSDLFYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q642</accession>
    <name>A0A8H7Q642_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar RNA-associated protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_002406</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q642"/>
    <dbReference type="OrthoDB" id="277439at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="460"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="565"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="737"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="464"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="508"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="638"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="669"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="765"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2185968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="941" mass="105633" checksum="623AFD1C9E24B9C2" modified="2022-01-19" version="1">MAAPKRGKHKQVKQKGKQAVTPRTSVANVFEASDDEQDLGRRGHTLDEVDNYEYNVDSIDNEDDEEIDSDDAFAESDEERFENFKFAGSHDKNITASKKGKRRPSLFDEDEEDDLNEDSGAEDEDDEEEDGEGFMDLSEMLGAGSDDEEVAAPKKNSAFDTLLPGEDSEDDQSDMEDFNDDEDEEDDMENDTDMVSFVSSLPTKKRKNAAEDGRGKKKRLSERTEAYDESEYSMSAHAQSSSGAKKKLDIADMMDALDDESGFGALKKNLRELEGSGKSKVKETLAAPLPKRIQDRLNRQAAYKEAKKEVGKWQPLVKQNREADHLSFPLQEHAPAANSNAALTGKFQAETSMEKQIEEALAAAGMKDKEEEEFEALELNKLSVEEVEARRNELRMMRELMFRHEMKAKRIKKIKSKAYRKVARKEKLRELSKVQEQMALDDPEAAREDQLQAETDRALERMSLRHKNTGKWAKKQLQRGAMDDGTREAINEQIRRGEQLRRKIQGMDSDDDFDGSDYGDEDGPITTEEQLKQIREELNEEEEPAGKGIFAMKFMQDAAKKEKAEAENLLQSTEDGLYLDESDSDNEIPRKEDKYAQVANNPGRMMFGIGKSTKKNTKETNDETIAQVKMNEAGEVSKVSTSASHNTKLSGPVDVKLPSKSPLADLDDSTTNNPWLQADTSKLAKQSRKANKAQGKTEDKAEMLVSKIKKNQKSQQQNADDDVEINLDNVLTIAQAKAKNAETKQRAAQQAPTPGKKSAPTDDTFASDDNGDDDDADVDGGMVHSKNPLAFTQRELVEQAFANDNVVQEFEDEKREIMEEDTPKDQDLTLPGWGAWGGKGLKDRKNVVIKKALPGEGVTANKRKDAKLGNVIISEKRSKKAAKYQVTAIPFPFQNREQYERSLRAPLGKEWNTTDSFQKMTKPRVMTKLGRVIDPLKAPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q760</accession>
    <name>A0A8H7Q760_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nudix hydrolase family. CPSF5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q760"/>
    <dbReference type="OrthoDB" id="277288at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18871">
        <property type="entry name" value="NUDIX_Cfim25_Nudt21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000005">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016706">
        <property type="entry name" value="Cleav_polyA_spec_factor_su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13047">
        <property type="entry name" value="PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13869">
        <property type="entry name" value="NUDIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017888">
        <property type="entry name" value="CPSF-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR017888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2186364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="196" mass="22557" checksum="6C21DEEEFA2FD695" modified="2022-01-19" version="1">MPEATLYPLANYTFGVKEAQPEEDPSVSARLKRLENDYEEHGMRRSVEAVLVVHEHNHPHVLMLQIANAFFKLPGHYLSPGVSEEEGMKAILNERLGPEDGVGDMDWEIGECISTWWRPSFEQYMYPYVPAHVTKPSERKQLFVVHLPPHKVLTVPRNMKLLAVPLFELYDNSARYGPQLSAIPHLLSRYDFNYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q7S9</accession>
    <name>A0A8H7Q7S9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Telomere-associated protein Rif1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_002769</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q7S9"/>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022031">
        <property type="entry name" value="Rif1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22928">
        <property type="entry name" value="TELOMERE-ASSOCIATED PROTEIN RIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22928:SF3">
        <property type="entry name" value="TELOMERE-ASSOCIATED PROTEIN RIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12231">
        <property type="entry name" value="Rif1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomere-associated protein Rif1 N-terminal" evidence="8">
        <location>
            <begin position="94"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1058"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1058"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1080"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1105"/>
            <end position="1122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2186331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1170" mass="131468" checksum="29A034F24FDC9993" modified="2022-01-19" version="1">MSSQSNATPSPKKVAFSPVRVGSTESQYHSMTPPQSKKGTAGTPRSILKISNSPIYSHENDISVVLDSSTGTGMGSQDENLSLETCIQNLLVAKEEDRLHTYSALYNALKSGETSTAIDEGMLRSVVKIILKDMESSNSIVIKQTSFRCMGFVLNYTADISSTLNAIVKIMNETQAKSIYTLCIWCLAMQRISKKVLDPHVPLLVKSAIAAVSPRLKSAKAQMEALAALDVIFTQDPNRFATWANCCFCIITQCFTNSLAPVRKRAAVVLSKMLPKIWGEPALLSSAIQIFLRDYATKFTEDMLKMIEDSPEDQDIMQLWALMIMVTGTSLHRSRFLNGMIRVAEKSFQCRRSDANINTFKAWSALIYNFRLKNHLLHENRLKLVKLPLEAGLKEEKHLSVRVAATKAWMSLVYACNEDFNQTFVFNSVVRDMATILSKDKSPIILDLLLQTLTALMNGHNRKVNRVSAVTVYFRQSDVQTADILPLSPVLIRDHQRVMMDVFKAGLRHAIVRLDTRSDLSFKKSYMEAWQAMLRTYRDLYQKEIRPSMAYIQAVHSCLNFLAFVILGEQTDQQGFKERLFIFKHLLKAMIDILGPEFLTLRSFELSIKSHMREDVVGSESLHQLNMVPIVFCLSIFIVLLCNNRRQAYQEYIETVVELSGACRQSSESFLDFVSLLECDFPRLDCSDEPENHYEIYSSQEGKEHCDTLQVKMKMAKTCIRHEFGSLHGIKCVLPQTEEVKEALSRLICYPLRCMCGNGETPSPVLNSKWHGLANEVFNYMPDGITDIARNIHNIIERTFTSLPNAHPHESLCWWLDFCSAQLRQCYDSSVGEDTDTALDTANQTVVQLGFISVHEQIPNIIVNQAFHLKSLHLDLKRISGYLTNVVCSLTRSNLDDKTLAAIAIRHMSAWQKALCGIKESSMSPNDFRDTITELLDFIVTLMCLLRKLPVDEHTLELWAQSMVALVRSSNPLISDPFVAKLKEPEYATSIAKHSNVEQVLISLGVLQPFSGSEQFKASPTTITKSTYQSSIPSPTQKAVLDSTAMICDDGLLETITSRPVDQESAKNTLFTPPRKRPRNASNKATDVVDLTSSSPKRSKPTHEISGTESNSSWSPKPTLTRKTVEVSSDIKHVPSLLQKAVEEKSELDRMEVRYVLSRLAVMSTTAKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U6L9</accession>
    <name>A0A8H7U6L9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002943</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U6L9"/>
    <dbReference type="OrthoDB" id="10254455at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140570">
        <property type="term" value="P:extraction of mislocalized protein from mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19520">
        <property type="entry name" value="RecA-like_ATAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000538">
        <property type="entry name" value="ATPase family AAA domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF3">
        <property type="entry name" value="FI08533P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="136"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2171321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="386" mass="43370" checksum="848F89EA3317F01E" modified="2022-01-19" version="1">MSSAREIAKCSLVMRSFLQRPETKKYAADIAVFALSQVAFYFAFKYIIGSLDPLKAKRQEAKSKSAKSLAKLGIKDLKLSEYEEIIATEVIHADEIHVNFKQIGGLDHIVQDLRESVIYPLCYPQLFTSASGLLGAPKGVLLYGPPGCGKTMLAKALAKESNATFINLHVSTLTDKYYGESNKLVSALFSLARKLQPAIIFIDEIDSFLRERRSNDHETTGMMKAEFMSLWDGLTTGEDYRIVVLGATNRPNDIDSAILRRMPKRFSVRLPTEQQRRNILEIMLKTTKLAPDFDFEKLIEATAGFSGSDLKEICRNAAMIPVREYVRSVEPKDHDGDASSDLLGIDMENVHIRPLMLEDFFHSDQTSGKKEHEQALRAILQQENLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8B9</accession>
    <name>A0A8H7U8B9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="5 18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">INT43_001348</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="18">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="18">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="18">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 18"/>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8B9"/>
    <dbReference type="OrthoDB" id="1696654at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit SdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="16 18" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8 18" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="19">
        <location>
            <begin position="58"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="191"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG2175701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="288" mass="32575" checksum="FB7F96026878E636" modified="2022-01-19" version="1">MSVSLMSAAAVRPALRKHIAAPIASYVRSFNSSATSNMANPAPPDNTPAKKEPLYKTFEIYRWNPDTPAEKPILQEYKVDLNACGPMVLDALIKIKNEMDPTLTFRRSCREGICGSCAMNIEGGNTLACLARIDRNASKPLKIYPLPNMNIVKDLVPDLTNFYKQYKSIEPYLKQKTPPTDGKENLQSIEDRKKLDGLYECILCACCSTSCPSYWWNQEEYLGPAVLMQAYRWMADSRDQFGRERRDMLQNQYSLYRCHTIMNCAKTCPKGLNPGKAIAQIKKDMAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8Q5</accession>
    <name>A0A8H7U8Q5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fe/B12 periplasmic-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8Q5"/>
    <dbReference type="OrthoDB" id="274765at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051030">
        <property type="entry name" value="Vitamin_B12-ABC_binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42860">
        <property type="entry name" value="VITAMIN B12-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42860:SF1">
        <property type="entry name" value="VITAMIN B12-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53807">
        <property type="entry name" value="Helical backbone' metal receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="332" mass="36451" checksum="A2926BCA9E5C00BE" modified="2022-01-19" version="1">MVVKSVGSTGLRVVSLLPSAAEIICLVAPHNVLVGRSHEDDFPNSITDRPILTAAKTTFTTSEDVNRQVSESLSTGLSLYELDAEGLSKLKPDVVVTQDLCDVCSIDLITVERIAKKMNPVPEVITLNPQNLQDVLANITEIGNALGFPEKAKSVKTSLEERVLKVRERGSKIVEERGNRVKVGFVEWIAPIFIGGHWTPQMIHDAGGIHPLNLPKNQDDGAGKSFAIEDQKFIDLQADVVIVAPCGLDIETTEREMNLIVEKSNQTDAPSWVTEYVKRGTKIAVVDGNQMFNRPGPRLVDAMEFLVGFINDQHDSIPSDFPWKLYSPSSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8R3</accession>
    <name>A0A8H7U8R3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF803-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_005550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8R3"/>
    <dbReference type="OrthoDB" id="165382at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF65">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="361"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2176316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="61566" checksum="C08B8637C6C24EA8" modified="2022-01-19" version="1" fragment="single">MNTPRYAPTFPEESHTYIGVVVSICGNILISVALNLQKYAKIDLAYPQIQQHNKLQKKSASSSTHLNGSLPHSSPQIGQNNYDDRYQNCQKSDLEQDNTDYLKSKLWWIGISLMVIGEIGNFVAYGFAPASTIAPLGTTTLVSNVILAPLMLKERFRFRDAFGLLLAVFGATVVVLSSKSEEVKLSPDLVVEYLTSMQAIIYYSITGGLILFLTALSPKYGSTSILIDLGLVALYGAYTVLSTKSVSSLLNLTLYKMFTYPVSYVLITVLITTAVIQIKYLNKALQRFDSTAVIPTQFVLFTVSAIIGSAVLYRDFDDVKAEQFVRFVVGCLVEFLGVYLITANRRHGEFKHANEDDVLPRTARISRRSSVQSSGPSEPYNESLDDGEHDTDTLYSHGADQYPATDTTPLLAPSHYDKQKTDDGNANSHGSERIRKSSVSVFRGISLVSQLAGMDDEPFDATTSGQHQLSTSQSSKRHRAVHAVGHLLHGIIPSKGHKRSAHDETEDGYDAIPIEIPPMDEENDVASSTGSLDLDIDFSNASEEIQLRRSSSHVMKEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U953</accession>
    <name>A0A8H7U953_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U953"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="557" mass="64718" checksum="DA2659290FCE318B" modified="2022-01-19" version="1">MSHSDSINVHKHKAGTSEGRKPDLQESIKTSLEVGLVDIYGVTVRENTDYLLEIYDRPDDVLKFEDDADYMELYATYRLNKAKRVVVRYTLIDGIHYLTRKDCCLQVGEHGNEVTFKEEKPEKQNILEFHATENNTFKILQRDKKIWLTWDKLSINYTGMFFQTNDNGEVYHKPVELLLRKKSIDIRDSIDILIPEGFDIASIDKCMMDYESNFISYDNEEAISSRLGSNFIVLHNNHFIAYAGKNHVKCDYNCRNRIIKQLCPSKGDEYYAEWIANDCHLKRIDGIIHNTIPPYMLFTNDYVREDDLTSNTIISGYTSLDPQNMVENIKSRSYNYSFFGCYFEEVYSFWLSETLENFGFELPLEQEIGYFLVERLCSSDFNGSLPQLKSDLIEFADKQQPDPSIRSPEFQLKDIEGLIVEENTDYYLTLYDHDLDVLILEDWHGDDHIPVHAASSGNGDTLIFRCSIINGIYHLLCNNKYLHFTSGYLAGISLMDQVPTKEQRLQFQVTKNNTFKIMPWNQSDYLKIEVMKASSCVLVFFSNGEPLELFLKRVSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9R7</accession>
    <name>A0A8H7U9R7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9R7"/>
    <dbReference type="OrthoDB" id="2406983at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="183" mass="20761" checksum="6BED7A0A202F3107" modified="2022-01-19" version="1">MEPNKAAHDLAQVRKLIEGMNALVNSQSHLQQQKSEPEEPVPTVSHESTPTINQSATTLTDTSNSLYNMSQLTTPLNAIIVEVNHLVYNRTLFFSLTPDATIEPLITWLRLSFEDPHISGMVLQYKGQDSLWKCLLNRDDSLRRVLKQTLKANLILQLRVPREQDLLSSGYTDKRLLQLTTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9S0</accession>
    <name>A0A8H7U9S0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Kinetochore protein SPC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">INT43_001490</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Chromosome</location>
            <location evidence="12">Centromere</location>
            <location evidence="12">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the SPC25 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9S0"/>
    <dbReference type="OrthoDB" id="6353017at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23784">
        <property type="entry name" value="RWD_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.50">
        <property type="entry name" value="Chromosome segregation protein Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021132">
        <property type="entry name" value="Ribosomal_eL18/eL18-A/B/_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013255">
        <property type="entry name" value="Spc25_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08234">
        <property type="entry name" value="Spindle_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01106">
        <property type="entry name" value="RIBOSOMAL_L18E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 12" id="KW-0132">Cell division</keyword>
    <keyword evidence="11 12" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 12" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Chromosome segregation protein Spc25 C-terminal" evidence="15">
        <location>
            <begin position="163"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="16">
        <location>
            <begin position="209"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="358"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="67"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2172013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="390" mass="45017" checksum="8AFDB639CF2A9990" modified="2022-01-19" version="1">MTEASAQWMPPTTNISQEETKSKMFTFLRQFDEHIRQEKGNILANRNQWIAQNAQDRENCLKMQSAIEKYKTDAELLSDKLGKEKEELQKATKDIQQYKEKRDDQFARNNELERQIIQLKRELEQKRLAKDTARNENAVQQQKNVPELLCYEEKLACKIVGVATDVLTFQFHNIDETDWNRKFSVTIQIAGKQYNLTLLTTVITFLPQGIDIKRHHVKNGHREAPKSQDVYLRLLVKLYRFLARRTDANFNKIVLKRLFMSRINRPPVSISRIVRHTKAVEGKTVVVVGTVTDDSRLLEVPKLSVAALRFTQTARARILKAGGEVLTLDQLALRAPTGSNTVILRGAKNAREAVKHFGMGPHQNKKPYVRSKGRKFERARGKRQSRGFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9U3</accession>
    <name>A0A8H7U9U3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_008199</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9U3"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="10">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="305"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="520"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="363"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2171819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="587" mass="65198" checksum="DECED4C4EBB1BACD" modified="2022-01-19" version="1">MPERHKDLEGASGSPSASSHGFKRKASEMSSATPPVDDFANALTSTNIAPQSILENLSSPSFASDIASLGTSMPSSTASSQPANEPPRAIMSSLQNQRFQRNVPAFLNKLYNMVQDPASNDLIRWSEDGKSFIVVRHEDLAKEVLPRFFKHNNFSSFVRQLNMYGFHKVPHLQQGVLQSDSDTEWWEFSNPHFQKNHPDLLLLVTRKKGRDQEEKEAPSLDLHHILDEITAIKKHQMNISSELKNIQQDNQVLWQETLSARERHQRHQETIDKILRFLASVFSGDKKRAIIPKKRRYLIGDANTEYGADTGSRIQEEDDDDEDAEEIEEIPLSSKDSNSILELNNYAHDSPDVQEPPHKVPKVSKSASVASNKSTRQNSTSTTPTFNPSTPLSTSISPPTSSASQQLADIQNSLANPNKNRDIINWDNIRNIQQLQNLQQVLNAAMNNPTLLDNLKYASYQAPTSIPTSTPSQSLVGFDPNIGHNAGYPAVSNSASANDLLAPLYNGDTGNNYQSGSPSLEAVTQKVNDNSRSAEEINQEIGKLENDIDTLTNHLGFDPNHLNVDDLDYVDMDEFLNTYGNGSADDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UA68</accession>
    <name>A0A8H7UA68_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">INT43_001032</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endomembrane system</location>
            <topology evidence="12">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03707">
        <property type="entry name" value="EFTU_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01254">
        <property type="entry name" value="PH_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000003">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="UBA" evidence="15">
        <location>
            <begin position="107"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="15">
        <location>
            <begin position="161"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="17">
        <location>
            <begin position="745"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="16">
        <location>
            <begin position="1129"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="16">
        <location>
            <begin position="1551"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="domain" description="Tr-type G" evidence="18">
        <location>
            <begin position="1877"/>
            <end position="2073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="210"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="471"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="523"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="598"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1418"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="480"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="545"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="615"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="646"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1423"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1437"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1525"/>
            <end position="1534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG2175385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="2268" mass="253905" checksum="E27D2B60657E8482" modified="2022-01-19" version="1">MGTHISKVKSVTMDSWTPDQIESIRAGGGNDAVNRKYNPHPEKHPLPLADDDHGMERYIRNKWEKKAFMDSPAAAAAAAPPPPPISKSPTGAAIPQRSSSVPRVLNGMDLNRSLATLRDMGFRDEEKNRRVLSQTNGSLESAIEILSKLPGQSTGIPQNDQMNDNQKLAKLWSLGYKDENQCRDALRRTGGNLEVAIDLLSKGAKAATASANSGYGNVQSQQKSAGSLIDDSDNNYIQQPTNMNPYQVQQQQQQPMQQSLQMPMQMQQQTAAQQMPVQQVMNPFGNFIGTPQPNTMVQTPTAASQSPFSFGMNGGQPQVQPQITGFNQQVMGRYQQQPMQPQQSSFASNPFSHLVSSASTPTNSFGVVTPGGAVNPFSSQPVTAGNTYGFPQQSPMGNPHNLPTRSYTSPNFNQNSNMFPGRSNLPSYCNVFVAFLCCFVVALAVMSNPITDDADYFSARHIAFHRPDAPSPLNTRFDGPSTPSDFTSPTSPIARRQVAHSVSADNTPRAKWQNLVHRLSTYQPRLDSGGEASEDSPHRSLWDMPSQSFNSPYQEDNTLPTPEECYNEEQAIGEGQAIEGENDEQPNFFQDPFPELQQAPVQHPAPTHTRWRVSDTPQTYSPSDSFHSAGTRRKKFASFLGRRPSGDSSRQDGFQMTPTAGRSEEDLHSSPSMPATPSRARAQWGKTLDKLKFINNINAAGRDKQQHLAQPSYPLVPFYPPAFAVPYIGFARDDKGRRPPPILFDLIGIAVADSWIDPTALNRQWVFRIELSYGEIKWVIKRTIVDFYDLHLTLRLKSSLNSDVPPPPAFPNQLRHLYQSTLKATISYIRRDEEEEKTDSKRTRALRRRQALDKYLKELVARSHLTIDNYDLCEFLEISAVSMVPDMGWKGKEGYLENRIHFVTPTLCQAVKMASWQGEWVILRDSYIAFCKDIGSRTPTDVFLLDKSFCLMAGGGLWFDKYHHHHIRLMNRFRKVEIKAGSKRVAEEWLEQIRKVQSESPWVQNHRFGSFAPIRNNARVKWFVDGEDYFDAVAEAIMAAKKEIYIEDWWLSPELYLRRPPEENEEYRIDRLLLRKAREGVMIYIVVYKEMSLALTINSEHTKIWLQNLHPNIIVQRHPDHGAGGGGVLFWAHHEKMVIVDNRMAFIGGLDICFGRWDTHQHRLADYPAEGHDKEIFPGQDYSNPRVKDFANVPQYDVPLVDKTTTPRMPWHDISIGVVGPIARDIARHFVQRWNYIKASKGAHRSTVPFLTPKGEYVAKRDESKFKGSCRVQLVRSSAEWSQGIEREHSIYNAYVECISKAKHFVYIENQFFITATTTEDKIIKNKIGQAIVDRIKRAHQKGEKFRIIVVMPLAPAFEGDFASSEASTVRLVMHFQYASISRGDNSIIEKLKAAGIDPDEYIQWYSLRNWDKLKKKATAPAVPSPPAASVSPPPKNETQQSNSTTNHYVISKSAPLENESNLDEHHDYETGSEDGSMAELTQERQTKDNGPAETKQTDQSNVRPSVDSKLSPAGNNESKADTISAVSDAQNGASDDFPEPKDGRLDYVSEQLYIHTKLMIVDDRIVIIGSANLNDRSQLGNRDSEIAMVIEDTDLVPSKMNGQDHKAGRFAHTLRMQLFKEHLGLLKTDVDLDDAPQSDLYDHFKETLVPNERATVVGDATGVMTRQSSTFNMFDNFRYDNLLKAEDQLVLDPICDQFYLNVWKNAATSNTHIYRNVFRCVPDDNVHNFEDHRKFIPDKQVVPIGHIADPLNMNEQTVKDNLSKIQGHLVLFPRDYLKDENMVGSYIKETTAASKAAMPAVRIASRRCVSSTASRSANIDFFRTLALVSTRQALAAGNKMTASMLKGAYVSAAPSRYMYFGRRYMASESGKFSRGKPHVNIGTIGHVDHGKTTLTAAITKTLATRGGAQFMDYSQIDKAPEEKARGITISTAHVEYETDNRHYAHVDCPGHADYIKNMITGAAQMDGAIIVVSATDGQMPQTREHLLLARQVGIQKLVVFINKVDAIDDPEMLELVEMEMRDLLGEYGFDGEGTPIVKGSALAALEGRDPEIGENAITELMAQVDEHIPTPIRDLDKPFLMPIEDVFSISGRGTVATGRVERGVITKGAEVEIVGMGPTQKTILTGIEMFRKELDRGEAGDNMGALLRGVKREQIRRGQVLCAPGTVKSHKKFEAQLYILTKEEGGRHTPFVDNYRPQMFVRTTDVTVTLKHPAGTENPEEKMIMPGDNVTMECELVHDIALEEGQRFTVREGGKTVGTGVISRIMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAF3</accession>
    <name>A0A8H7UAF3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAF3"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="149"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2174322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="374" mass="42812" checksum="E6D9B4BC02095926" modified="2022-01-19" version="1" fragment="single">MQAETKTVRHHPSHLSLESRTTPVDDTILSPRTPKSIQKPTLSRRTSNITDALTEMHLQRTPSTSNTPTTEPAQYFPEQQQQAPPAVTKYRTTSIGSAASFSSRAALNANFDVHTMYKIKTSKSNKKLDNFFGEAAPMDICIQEIRKEGLKAMLQSKVPLCFLLYHLLDEYSSENLFFFVEVEQYESFTYVSKAQQLATASHIFETYLSRNSHFEVNVEDKVIRSVTTAIEDRQLDNCFRTAKRSVFTLLDGSFHRFKDGPIWDNMVATCGELTTHYSTDARNTAVTLLLQYLERQHNLLYTNPHVSVPKTTRRRHELLMSMIHEFSRQLLDVQFAYYHRNLSPEPDSMRMRAGSPMSDADNSGSDGDRIKRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAV4</accession>
    <name>A0A8H7UAV4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_004542</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAV4"/>
    <dbReference type="OrthoDB" id="2400571at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2173168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="473" mass="50886" checksum="F80806AADC785222" modified="2022-01-19" version="1">MYINDVKFACATCIKGHRSSHCNHADRQLFEIKKKGRPVTQCAHCRDLRKQRQIHVKCICMDRSTSQSEPATASSSPSDMEHTAQCTCKKAKKKTSLRRPVHNPSLIAIDMTQSAPSSRGTPSPPTSASPYLHEPNSWSWALIAPKQDNIDTDSRPNHHLSANDNGDYSFVFHKSAHGKNQKQQRRRSSLSSRSSLIHTPACTHQLARAPSSDSSVKSEPVVLSDNEGNSFALYSGSSDKHNLQHPLSGSDPLGSKAIFPTDLDDEAAAAGSLDFSFNLSNDLAMLIGDKQATPGEAEDMANFPISSTSSVSGDFTEDLSNTLTFDSAAELMAIFDTDLPQPLPPIQPPPPQRPKHTHHRPTNQSCCGSFAPSNACCNDTSLPGESVCISITPVGGAASNQQQPSTRIVTCRCGIGCTCPGCLVHAGASWLMDPYAGVPSSGCSSDDEDLVMMDEGTSKPALQWLNNSTPEPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UC99</accession>
    <name>A0A8H7UC99_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="10">PPIase</shortName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_005506</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UC99"/>
    <dbReference type="OrthoDB" id="2083at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01921">
        <property type="entry name" value="cyclophilin_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12235">
        <property type="entry name" value="RRM_PPIL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000015">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000287">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035538">
        <property type="entry name" value="Cyclophilin_PPIL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="6"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="244"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="172"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="355"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="355"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="421"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2176272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="459" mass="53182" checksum="8D7605521449FB9D" modified="2022-01-19" version="1">MSVLLETSAGDIVIDLHTKHCPKTTLNFLKLCKIKYYNFAPFHNVQKEFMAQTGDPLGTGQGGESVFGLLNGPSQKYFPAEIHPKLKHKKRGTVSMAVAADASVASGGVSGSQFFITLGDDLDYLDGKYTIFGEVAEGFDVLDKINSSFCDENGRPYRDIRIRHTIVLDDPFEDPQGLQVPDESPMPTKEQMESMRIGEDEDIEEHGDPEELEKRRREREAKAQALTLEMVGDLPFAEVKPPENVLFVCKLNPVTRDEDLEMIFSRFGHINSCEVIRDRKTGDSLGYAFIEFDQKDDCEEAFFKMQSVLIDDRRIHVDFSQSVSKLHTDWIAKRLKNQPEAVGGVEGLEKRKRYREETAHERGDNYDLVFEHSKRPRERSRGRDDDRPKDRQRSRDEKGRDSGKHSRRDDDRRRDGHRHRDRESDRDRYRDRSSDRGRDRDRGSYREKDRDSDRSRRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCQ3</accession>
    <name>A0A8H7UCQ3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003368</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCQ3"/>
    <dbReference type="OrthoDB" id="551633at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2178115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="27427" checksum="1FA5158ACCDDC9D1" modified="2022-01-19" version="1">MNNTNLLSAGSKIYAKKRKQKKETVERIDFDFDARKEFLTGFHKRKLERKKKAREIAIERERVDRLQARAEAREERKRLADTNMAQMAALLRQQNGEDEGEEEEDVKFDSDEELDTPVAAKIEPTVKEFATPTSLTTVTVIEDLELDDSYQSSAGNKRKAEEHEADQEDDEKETKKIPQKNNKKYADKKPKEKKKKFRYETKAVRSKNQSKAKDNKSKRNEEMKTGRKGGKGKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UD10</accession>
    <name>A0A8H7UD10_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_001065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UD10"/>
    <dbReference type="OrthoDB" id="2536440at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009069">
        <property type="term" value="P:serine family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000118">
        <property type="entry name" value="Related to CYS4-cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="354"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2175418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="508" mass="56491" checksum="FF9C8AFBA2FD39E2" modified="2022-01-19" version="1">MPLDHQPPIITQNVADTVGLTPMVGILANKSNNVQVLAKLEYSNTTGSIKDRTAKFIVQDLMAKEKMNANTTVIIPTSGNLAISIASLTAKQGNKVIAVVPERTSVDRIHLLKSLGVEILRTPTEARREAAENMYPTAYKLSEQLKNSIVIDETNLPANVYDDLAEEILQQTKLTVDHIFVGAETGSTISRLAKAMKSRLPQLKVYGVEPTESVFAGSGSEKHHKRSDWKIEDLGSNFVPDRFDGSQIDGWIQVTDKNAFSTARLLLREEGITCGPSSGAVVWAALDHASKLPQHTTHIPRSVVILNDTMRNYTSTLLSDEWLLENDLVDDMTTKQLEYLSSERYRAASVEDLQLPAAVTISPSATVSHAMNLMLEREYSQLPVIHSSNKKLVGYISMSTLEAHLADGSAKPEDPVNKWMFNFLKRSTTDKPTPKYQVITPDTSLADLGKPEMNRIRMNYSPRLTSLCTAKFFEKNSFAVVTDLHRKWCLGVATKYDLIDFLNRRNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDE6</accession>
    <name>A0A8H7UDE6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_001711</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDE6"/>
    <dbReference type="OrthoDB" id="1937934at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22455">
        <property type="entry name" value="KH-I_Rnc1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22456">
        <property type="entry name" value="KH-I_Rnc1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22457">
        <property type="entry name" value="KH-I_Rnc1_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049786">
        <property type="entry name" value="Rnc1_KH-I_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="26"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="114"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="250"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="207"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2178865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="338" mass="36337" checksum="C43EB3EDF95DCAC1" modified="2022-01-19" version="1" fragment="single">MSDLSSPDHDQYPSPTLQSQQQQDSDLLTLRALVSTKEAGVIIGKNGKNVAELRDATGVKAGVSKVVQGVHDRILTVVGSLESVAKAYALIAQTLLDNPLSTPPTSPTEANKGSVASIRLLISHNLMGTVIGRQGVKIKHIQDISGARMIASKEMLPQSTERVVEVKGSVEALQIALTEIGQCLMDDKERAFGTVLYNPVKVTQFGGSSNEGRRASITRTGNGSDFSNPAMGSSERRMSSSSQTLVNDPNLRTQNIAIPSDMVGCIIGKGGSKISEIRRLSGSRISIAKLPHNEQGERMFTIQGTAQANERALYLLYAQLESEKERRLKAAQEDELDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDZ6</accession>
    <name>A0A8H7UDZ6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hook C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDZ6"/>
    <dbReference type="OrthoDB" id="49395at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008636">
        <property type="entry name" value="Hook_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05622">
        <property type="entry name" value="HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hook C-terminal" evidence="2">
        <location>
            <begin position="19"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="264"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="455"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="587" mass="68533" checksum="FCD2F42D9DF885FB" modified="2022-01-19" version="1" fragment="single">INFKQTLPLETKLNLRCSQEELEADKEDLKSRLLDMDAAVTQANDTGKADFIMRTEIEHLKQDLSRSEDRRQETELVVEKQNRKMAENERKIEDLSKAAEQVQYLNDQLEEYKHTEEKLHKMENAIEKYKKRLEDGADLRRQIKALEEQNATLMERNQQVEDEYRKVLSFKTLMDSYKEQVHNLENDKAEILIEKHKIEEALRKAEERCNMLEQDKARDQDQIHTLEDQLAELELGGAQSMGSLADQQDSATMNTVVDTPNMEEDLQKANMAEMRLTIKRLEEQVLELQAKSADGQNEEVNALQAKIEVSSASERKWQQKHAELEGRYQLLEKDILKIREGIPDTLPKQMQAIKTFRARIIDLEKEGKHLSESTSAFEKRVTEATRAVSKDGATLDAFEKEYAVQQERINRLEDITKIQLHDINRLLIEANYLNGINNKSGNNPDDAPGMSDKELENLKERNATLQIQVLHLQEELNETQSKIRRAREMIKLYSKLVKESLVSNMRPHDLSYVQKVPRTREEENELLKRQIHDVRLQSRKEQQLIISSWYELARREKRDSASLSGRPTSSSWLGRQRKILENQLKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEA9</accession>
    <name>A0A8H7UEA9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_007442</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEA9"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039525">
        <property type="entry name" value="RNF126-like_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14369">
        <property type="entry name" value="Zn_ribbon_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="312"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="108"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="164"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="360"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="367"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="424"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2182511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="465" mass="49612" checksum="669E8F394EE50F9A" modified="2022-01-19" version="1">MPPQRPQYWCHQCQQEVQVLLAPEPVCQRCNGQFVEQIEPENDPRDFVAPVDEDNPAIGSAPGAYYTFNASGPNSNFFQFYDGNSNNAAEQPGGGALYGMLQALLSGNLPTPPIPTDRNPNRPTDTGMNPSGETAQSGDGGDGTRAGRIRQPVMFMGSFGADGGVRFRTVQGDSQMPGGYQENPQSGPGMPESPRPGEGRDQGSRTANMINLIQMISGLSGSPIHLNFGGSANPGDYVFSQTGLDNIITQLMEQANSEHAPAPATDEMIESLEKKKLDESDIGNCHTIITIYIEKSQANQIFTTNAEKYSHCAICTDDFVKEDEVVTLPCEHPYHKDCITPWLKVNGTCPVCRYSLITGQKPKDEASGNNTANTNASGSNASQAPPASSVNTNPTNTAPPTMNASMSWESSIPGAFVWGPGGDNQSTTNNTNTNANTSTSNNSSSNDNQPGQNDPGNPNNVLDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFP6</accession>
    <name>A0A8H7UFP6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Guanine nucleotide-binding protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_003734</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFP6"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002307">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="150"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="175"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="269"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2179947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="40564" checksum="7BB0FC3D27D55B1E" modified="2022-01-19" version="1">MGCCQSVEDQDGKLRNDEIENQLKKDRANMRNEIKMLLLGAGESGKSTILKQMKLIHDGGYSQDERESFREIIYSNTTQSMRVILEAMESMGLDFANPQNHDYASIILEQPPQIESDVMPQEVGAAVKYLWQDGNVKLAFSRSNEYQLNDSAQYYFESIDRISDPRYTPSDQDVLRSRVKTTGITETTFVIGDLTYRMFDVGGQRSERKKWIHCFENVTAIIFLVAISEYDQVLIEDETVNRMQEALTLFDSICNSRWFVKTSIILFLNKIDRFAEKLPTSPLSDYFSDYRGGNNYDSACDYILNRFVSLNQSDDKQIYTHFTCATDTQQVKFVMAAVNDIIIQNNLRDVGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFS9</accession>
    <name>A0A8H7UFS9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase kappa</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">DNA repair protein REV1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Reversionless protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">INT43_003839</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="21">Binds 2 magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFS9"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17719">
        <property type="entry name" value="BRCT_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01701">
        <property type="entry name" value="PolY_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000001">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000011">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012112">
        <property type="entry name" value="REV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002677">
        <property type="entry name" value="PRK02406.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036573">
        <property type="entry name" value="REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 21" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="23">
        <location>
            <begin position="46"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="24">
        <location>
            <begin position="274"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="25">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00058985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00081902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR036573-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAG2180052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="762" mass="85175" checksum="D7D65730384BA656" modified="2022-01-19" version="1" fragment="single">MQQDEPPSPPDDTYNSIRFGDFKSYMERKKRKLKDQEQIILAATNENSSIFSGLTIHVNGYTRPSHADLRRIIASHGGDFQHYLSKSKVTHVVASNLTNAKVKEFRAYKVVTPNWIMDSVEAGKLLSWQDYRLNSPMEVHQKELAFQSQAASRQSEPEKESSNDLISLSPAVSVVDSAGEPENNTFKNLSRSPKGKETAKILGSTLNDALLSSEWARENSTINPAFLDKFYTSSRLHYLSMWKAELKSIVGKLRGLHSSQSQKPKLPRSENTRIMHVDFDCFFASVGTRDRPFLQGKPVAVCHSKGATESSSSSVASCNYEARKFGISNGMSVGHARRYCPSLEVIPYEFDKYKEVSEIFYEILYGFADELEPVSVDEALIDVTSSTTAAGNSEEELATKIRSTIREKTGCEVSIGCGSNILLARLATKKAKPCGQFSVSNDSVLGFLEPILVEDLPGIGYAMEEKLNSLKISTIGDLRGFPMPLLQDKFGKKTGETLYKFARGIDYRPLAVNQARQSVSAEVSWGVRFENDEQVYDFVFGLCKEVQKRLRQIGCRGKSITLKVKRRQLDATEASKHLGHGLCDNFSKSAALEFHTDDAQLIFEIALNLLKSYKFFAGDIRGLGVQIQKLDNDIAKNTVEEGQSILPFTTVKANDIEKVIATEAIHHEQNSNLDPPTEEQRESRTAPVIVCAKPEMEVERQSFMELPLDIQSELHRVYQIIFLEHKKPSHVTDAESNDDLSYEVNTNILGSQQHTDLAYNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFT5</accession>
    <name>A0A8H7UFT5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_003854</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFT5"/>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057962">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23335">
        <property type="entry name" value="CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR CAMTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23335:SF1">
        <property type="entry name" value="CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25603">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IPT/TIG" evidence="4">
        <location>
            <begin position="552"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="726"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="759"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="245"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="372"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="673"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="675"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2180067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1017" mass="112024" checksum="8A9239EBC6FE5A9B" modified="2022-01-19" version="1" fragment="single">MANLILDHSNPPSPSLMYSSPGSSMSDSLEDSFMDYLQANTHDNSNDFYSVAHSDGMDSPQPPTTPLSQSCFHSDQIIVPEGDLPRVEQNDVFDLISTSSSHALPTLARKCLSFDSLTSLSSVDSTNIQSNAKSANNFSDLQIRILGIPGSGAKSRVETQIKLCIQLVTDRGDKVPLWSHLRLPEHLVAKEKYKRVNQQKSESGANVAINDTKLLTLEATVKCYSDPSRKVETCIGCIRRERRRSQRKKENKQKPTERDIPDSLPPSPTSSSGKDADDNNVSALEKCRVLLFNCSEMIDFSSGDCILPTRITCYCRHHNEKVGFCIHFTMRNHRNQVVAQGVSPAIMITDDHKSSKSKNASTLKRNRAEFENLLSQQTSDPITPACSRKTSPQRQLSGTESSSTSISAPTTPSPTNVPVSILPRSPKYAKVDSDLNMTAIKSAPFMSIPHDTLEQDRTSHPLSATNASLSAHIVPTITNDICQPPAVPSLTPSLPEYRHRLSLPTSNINLPPVAARRRRTLNTYNNMTNAPGGLLSAIQWQSTLANASGSNVPQLNRLIPAEGPLYGGVEITVLGSGFYDGLTCLFGETPALPTHCWSQNTLVCVLPPATTPGTVVVSFKEHPLVVDGQDIVLFTYYDESDRALMELALQVVGLKMTGKLEDARQIAMRIVQGDNNQGNTNTQNSSNGHSQQRNGGELEQQIIQALENVVNLETSFKLPVSLTNQQKHSLLHLAVILGFTELTQLLIQLGINVDQQDRNGMTALHFASWTGKQDIVDILLDQGYANPDLVSSHAKTAIDLAMDSKHTEVVEAIQCYQQMCNSSSEDSDNDERSDREDIDTQDRIVEWLSGSQVHHLDSDDDLIVDAIDSNIEPVKPHEPQEPLRPRQFGDLSAWMQRTFGNKHKASLIPNSYPPNFLSGNRKLTTDEETSLLATAWYLAIASMMSSSSAHYQEKSSSPFIPMDLSVPGAALSSKNVIDLGDTDPDEADCYMDSTSLDNPVHFHQDRRLYLFWFPLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFY3</accession>
    <name>A0A8H7UFY3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_004006</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFY3"/>
    <dbReference type="OrthoDB" id="18595at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039603">
        <property type="entry name" value="Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019083">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235">
        <property type="entry name" value="PROTEIN FYV4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09597">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01238">
        <property type="entry name" value="IGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS41 SAM" evidence="5">
        <location>
            <begin position="41"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2180217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="109" mass="12393" checksum="6CA42DCD3ABEE785" modified="2022-01-19" version="1">MATLPRKLSALRRILPQARFTHSGPNASKQVPSPRGEITDVEAFLKRAGRGSDEVATKFQDWNHLFSASSRDLKEMGLPTKQRKYILSRVEFFRQGIDPYPIAVKPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UG61</accession>
    <name>A0A8H7UG61_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Probable glutamate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
            <ecNumber evidence="4">6.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glutaminyl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">INT43_000460</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EC" id="6.1.1.18" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UG61"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00807">
        <property type="entry name" value="GlnRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000007">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2420:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1290:FF:000002">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1290">
        <property type="entry name" value="Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007638">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007639">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042558">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042559">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04558">
        <property type="entry name" value="tRNA_synt_1c_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04557">
        <property type="entry name" value="tRNA_synt_1c_R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding" evidence="19">
        <location>
            <begin position="3"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding" evidence="18">
        <location>
            <begin position="163"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="16">
        <location>
            <begin position="249"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="17">
        <location>
            <begin position="561"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="20">
        <location>
            <begin position="674"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG2184551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="821" mass="92653" checksum="A6AF8565AB657D67" modified="2022-01-19" version="1">MDDLIPLFVKVGLTEQKAKDTVKNKKLAPTFERVINEAGGADGCSKETGNLLYFLASKITKDAEPHLPFLAKKIASGDLKSTEQVSAAISFVEEKPEPIDEASFNEETGVGITVTSEQIDEAISKYIEQNKDNITENRYRTLGPSLAATKKLSELRWADGAAVKNQLEAQYLALLGPKDERDAPQKKKKEPKAVAPKVLADQAAKTDDPAAAANKMFFEGEISNLHKPGGNKQINPELMKKHLEATGKKVVTRFPPEPNGYLHIGHAKAINVNFGYAKAHNGITYLRYDDTNPEAEEEKYFSSILDTVKWLGFEPYKITHSSDYFQDLYELAIKLIKKGLAYTCQCTGEEIAAHRGGESRGPRTACVHRDRSVEETLEQFQMMKDGRYKEGETTLRMKMNLEDGNPQFWDLIAYRILYTPHHRTGSQWCIYPTYDFTHCLVDSLENITHSLCTLEFRQSRESYYWLCDAVEVYKPVQWEYARLNVTNTVMSKRKILKMVNEKYVNGWDDPRLFTLVGIRRRGVPPEAINNFVAELGISMYNAQTDVIRLDNHTRDYLDRTAPRLMAILEPVKVVLENLPSDYLEMVTVPNKPRDPSMGEHTVPFTNTLYIDAADFREQDSPDYYRLAPGKTVGLLHTKAPITCTDVIKDANGKIVELRCRFENGEGVKKPKTYIHWVAESPQHGSPVKLDDVRLYEILFNHANPSDKTLVPGGYLSDINENSISTVTGAISEVGIYDHLQDWIKKTGGKDLESARWQFVRNGYFCLDLDTELDIEAAKNGNVKTAAKKLVFNRTVTLKEDSSKDDAVVRKGGIVDTRKRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UG82</accession>
    <name>A0A8H7UG82_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TIP41-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UG82"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2178089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="31563" checksum="B4ABAA7DFDBC851A" modified="2022-01-19" version="1">MTSTKIMHKLINEGTKREGQTNGIEYNGWKILSKKAPICNSQDIDKLQGELGIPLPEMIFGNNEVKLSHEDGFEIFFRAKDALELVDTTSESNKHIKVAYASEWGKKSAQNHEEIKDVIKPYDWTYSTAYQGTSANEFSDSEKCIDVDRLKQMEPILFYDENILFEDELADNGTATLTTRLRVMPSCFFLLLRFFLRVDDVLFRINDTRIYHQFGTDHIIREYSSKEEHYNAVRSRLPKTPNEDISLLTDPNWVSSILPTDKQIRINQLANIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGU1</accession>
    <name>A0A8H7UGU1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_007456</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00243">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="63"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="276"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="GAR" evidence="7">
        <location>
            <begin position="3045"/>
            <end position="3119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="397"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2976"/>
            <end position="3048"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1111"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="2044"/>
            <end position="2071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2976"/>
            <end position="2992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="3000"/>
            <end position="3015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="3029"/>
            <end position="3048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2182525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3211" mass="366083" checksum="A89818E634D9746A" modified="2022-01-19" version="1">MSDTPATRQITNHESSSVPTSRSSRLRENGGKRVRQTSVFGDMGGAGAGAEDGGRNVAANYQEIQKKTLTKWVNAQLATVGDSISNLDTDLKDGKKLLKLLSVVSKEPAPKPERGNMRIHQLSNVSQALSFLESHLGDETMPNIGNEAIVNGDVKKTLALIFFIMLKYQIQQITEDPEEVAMMMEPEEIDEVNIEEDIVKDSNVDSTVKVPEEKRESGNETKNDLDDETGKGGMTDREPKNALKSPGNGIAKLKQRLPAQAAFKSSTGEKKAPGKADAKLALLYWVRTQLEEYLVASIIPPIGDFSSSWRNGLAFCLLIHHYDPELIPDLMSEYLQLDLNDKATWRTLLSLAFDTASQHMGIPKYLDAEDLIDVDFPDEPSVMMYVSEYYKIMSRPRKAPSVPKPGFKWSSHSKQESVSASHENTNVEEHNTDSEDVQVNSPVPSSTSNGAAKLKMVRGASPPPTPAPAQRKALNRLSSLGESDKARVKLNITNQLQQQLTGQLPFGIDLNLDQFISLHESILTFIKSHRQQINELSENIAEADAKSIMEYLDTLDTIEGECGVRSKDMAKSIEIKDKLEKQWKDDSSQVSIYLTIEQHTQILKMAETIESEWRNFNWSIQTTKERLLEKNLLIATHQVQVDDMEHQCEVVLAAIASKQYDVDSSCPTREVDGHMEKMHPLEATDDHAELYSMHLDKLEFALEAFTEAFWQPFLQSVSQTTPDIQTATHSKVNDCHEAYNKLYESFHEEQQKSRDFHRGITFVTVSNAIGSELDEVQSRMDHAKSSTTEDGIQDLEARVSIVRDMLSNFHERFADLIGDATDDDDNEVADSSAVSLDYYGRFKIVFDELENKYERVRDWVDQVRLWFVEAERIRKWIEVRIDIIEQEDKDRLESLDTEVFVSHEEILELLQAHEKLEREVERFNQDDMSRLRAHVKALTGSERQTKLSPADTTTIEITLMTLNILDRLMHMLRQHSAVLQELLLRILWEEKFEHAVVWVMDMDKRVDEFLFGAARWSMREEQFESDEDAHPVKTAMEKVISTLLDIEQTVADFDQGFYSETLDAYQDLEDAVSEDMPDYLTTRQTGLESTFEDLSKRIAFTRQAVEQHLAVMDLMAQFRNVKEEGENLRKDLSIAERTATADDSDMVFIERNSEFQQHSVHLVTNVAARIPYPTTPQMETALGAQDAHENELANQEIKSTVTALGMQLALIAEGIEQKLASYRHVLELQKRCKQLCDEMHRMTVWMEEKIVNIKQSKVNPAVIDRLPFDNDELLRLEKEKDGIQSRLSILEEGDLSELFENVRLLEVEVDASSSVAVDRSTVINSVEALSDQHQLLKKILNEHAQELDVVRKRFTWETHVNRCQQWISTTARKLSEFADKKAQCRPSIELSPSFGEDDDKAQTFQQLQNRLTEFTEKQLALAISSFEIMVEELSDILRDDEPVPGHIQDTQKQLLQTYHTLEELFAYVAQLLAQRSIYTEYALRSIELQREAEKLRDAIKKSFRRIMEDSNTTFESRIEVLKSEIENGRKECIDRLPIAVFDDSLTKLWSMYSQAKPDLQAGDSIKQTMKRKQAELDALVKVIEDMYNNLQGALNCKDQISMYNTELLKLQEWIIPRGKSLVASRINVTSDDLSALTKDYISEQVTALEQNEEEINEFETTRLRVVHDNIASLVQKILSQPDYKGLDVSSIANELERTLAAFRQLRDEITYQRNLIGTAEQRARYDEAVLELLALLQSFTEKLGILVVTRDALLTRNELTQSHLENFHSDLLEIDDEVQSSVKEMLSNCQSQYDAFVHKLTKLNPPLSEPEHLRLQLNRLQQSISQTDETVATRLKEHSLLERRLELDNSIQAALTHLQSFKSNIFKFIDEKAKWHSSADVKEKPDDSLQKHYEEKDAELLDYDQSTLSQLQDQFAVYKQETTFHGSQFLHHIDGKIEQMTQDRNASQSALEFAKNVVAQRLIMDNFIRETNMLEDKAVAIRNALTSSANVDEPSDMIDKFIDDVKLAKTNISSSLTFPVRPLDVTEQQQQRDELSDNVIQETVKARTNRLEELSESLKTLLKNREHSSRRASSIDSFKAQADTSKQWIEYRIDLIQSTMSKSETIFTTREMRPLVQEAESLDTAVDSYRHLYTSLRNECNATLTVLREDNGSVDVAQDIATLEKIQQELDDLWRELLQKLSDALSHLHSSYESKEYLETANNLLADLEHLLQTIMSVEPATVEDALLDAWQADINRKETRELKEIQDTIARGPQDLLSSDFMKLQAIVDQTEDIVAQIRKHLAYLYDQANINGLRRNYYSNHAPLQEQFANILTALSELLQQKCILPTSDPSTQDGLLDELLKQQFSIVTLVNDQSDAYNDLRSLYAFVMSQEHLADIETEQSELDESWSLIKEKQHIADKALQMLKQLSSQYAVLNKIRGNAEDREFKLQGLASSDGAEKESLVERLFEEVNADKSILEEMKEAARRNQTSLVENMLSVATNQEAFMEYFGGVLDHLHQQTASVKELQGQLSNERTVEQFSKDVADFVASQGSLYTSMISCLEKDDLVSSSEKLEALFTEMNLKVADVDDRMVFSQDAAESLRHRSNSIVNRWPGAKLEEAVQSVDQMMERLSLGQLLLSKVHDLVAKSLENNRDFFAITATLTTWKLNATQNVLEENHSESGNDTGYLEKLNKQMENFENTSLHEFEASCRRIESMCDELEARQHKTVTGIKDVVQSKLKSVTKDWNSLKAFLNHAQQNAEDNRLNTLASEKINELIRYVSDTTRHINSLQLSDPAVTVDVREFECLQKELKQALATKTQELDELFESKFTEDERVTELRSKVEAQVTDLHNLIQDRKEQTDMAAKLKEHMELIDQLDMDIGRVATSIDKLAPQHARLVENQLIKSDLQSMLQSLNQIREKRGKMIESQLVVVKKSSDALVNDWRADKRLGTIIDKWHKLQELMQVRGQELEICIQKLDHEFYTKLAAAKTTTRLTPRRPSLTPSTSSRTRSDFSFHRNSSKISLQSHSSTESYRRRRSKSPAPNPNYNNNLVKPHNQYLSDPNSDLDTEVGRIVNASPYRIKVKRVPGEVGKYWFGEENRRLVYCRILPSKLVMVRVGGGWVELAQFLSDHGMKEGTFTRVKEDLQTKSDNLIPPRATSPSGRVVLRGGGGLATPNVQSRLNGPGKGTNPAMTAGYKDGNTFVRIDEQGNHVVAKMTKAKDSTIWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGV6</accession>
    <name>A0A8H7UGV6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGV6"/>
    <dbReference type="OrthoDB" id="10323150at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2182570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="134" mass="15225" checksum="2303C14665F41547" modified="2022-01-19" version="1">MTSASIAHIEIFLPEPPTQRNVFSMFINIFGSRSKSPSSTSENDRPRKRSVGQKGVRFNNSRVVYYTHSKTDYDRGGMSWLEDDNEPTVVVRTRSTSSIRPPVLDSDDEDSLEVDLNTISKSSTRSRRTSFRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UH85</accession>
    <name>A0A8H7UH85_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UH85"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00072">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051640">
        <property type="entry name" value="GRB10-interact_GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445:SF36">
        <property type="entry name" value="FI03272P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445">
        <property type="entry name" value="GRB10 INTERACTING GYF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="328"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="780"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="943"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="602"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="871"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="953"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="965"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="989"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2179079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1115" mass="120831" checksum="5ACA2DAF541D5942" modified="2022-01-19" version="1">MSTNMNFGPEWMRGTLPKRANNLESSRSISPTAPISGSATKSASSHHPAIQRQHSILDGLTVLDQNSVLGPSSSYIGQDDQHDNPYKYSKEFMLSLFKPYALPVEIERHEYVVVEDCQQPLAKVELTEHEKKLLSGPAHSNLSRKRADIVADTSADGRSLRNKSEFANSPTIEKDASSTRFGLNRAKGRQSENVTSASMAGELQDTDSASLRSSQPSAQGLNQSDDRYQDHANSANWNQLSTSHDPHFDESSVLSVLDEGKGSSNGMFDPPSSTLKGAGHLNDRFNSLSLGSSSFGGNIGVDMGGKVDSPHSFASSTPLGDLRKAPEQYQWYYRDPTGLVQGPFEAQDMHDWYKAGFFSQTLLIRREDEVSFEPLAAFIRKIGDEDKPFLVPYSPQSQTSVRTPLDFGMQQQSRMLEDPFLRSPFGIAGQFGSQPPLQHQSDMLLQQQLSGSHLGGLGGLGGNFFQQRPTSAQSPSGLLGSYGNFGSNLFSPPRESGMGSPWAEVPPQVTPTRGSAIGGADLFGGNNLNPLLSPHRQTPTQQHNQLFTDPAGQAGFLDHSQRSLSQQQLQHQQYMQMLQQKQMFQQQQAEAMNASMHHLHQRQQQQLQQQQTPSSTQQDQIDSAPNQSTPVMAASVAPAAEKQAKKSGGFNGWGSAPGTPLFGGASWEPLVSTPSRTLVDDPFERRSAVQSPAISPPKQNKTLDISKSDTADQQRRHVEELLTENADVNILSSLSKSENEITIQKAAPEVATPPPKLPSVITAPAVKPISLREIQEEEMKKQKEVAKQQQLSAKAPSKPTGWGASTPWSLSDDMPKGLSLREIQELEAKEFEARKILEKQSAADLLAPNSPLFSTPSTMSWGVVSPGKQKPATPSGAAGAAPWASTTAPKKTLREIQMEEEEEARKAKVAQQQTASLASAVSQTSNIPLGSATNSSTKGYAGIVGNTGIRPHTPTSSWTTVTGGRATKAPTASTSSSRSPWDTVGAPKQSPSVVTNASAGSAAITKPATGEKKGPSEDFYRWCRQALKGLDSNVDSEDFMQMLVAFPLDNSSVEIIQDMIYANSTSLDGRRFADEFMKRRKADIAGKLDISNVMASDDDTNAFKVVSKKKKFVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHE8</accession>
    <name>A0A8H7UHE8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF300-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_006165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHE8"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="577"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2183170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="620" mass="69318" checksum="BF89275944A1598C" modified="2022-01-19" version="1">MSVHRSTTMVDGGGYGEGGSGEKLGATAIYIAAAFVFVGTGISLISIWQHLKSYRKPFAILEFTETSYSHFVDVSWVPIYGISSLISLVSLNLAFYVDTFRDIYEAFVIYAFFNLLLNRLGGERALIIMLHSRPPTENFFPGTLYSREIYVGDPYTFLFVKRGILQFVYVKPILAILTMILKATDNYHEGQISWTSAYFYLTFFYNISVCLSLWCLVVFFYATKADLRDFRPLPKFLCVKAIIFFSFWQSVVIALLVAAGTIKAEGAEHIAVAIQDLLICLEMVPASIAHSLAFSYEDYLEPNVHSARMPLRYAIRDSIGIKDVVMDSIDTLRGSQFNYHAFEPSEGVPHIGSSRTSRIMAGLRYSTSTAKKHWLEPAPVSQYISSSIRGAPNSDRLAAWGEQEGLEFPDLDPNEEVEQLYASSRNMLFGDYNFPVVDFVAPLYRQGGKSSSYGATAQSGSLQSKRPSIANNRYTSSMNSVIPDREGCVDVIVERGRGNYVLNYQGRSKPPIEANTSPQKVKAIAEAKRKTLERSLTPRLQEARPMTLAPHITSTSLHSDNAVEVLDDQALEEAQEAYKDSNLQPSSSHTTKLPKDSDSETVSFLDDMDENQNVWKNGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHG2</accession>
    <name>A0A8H7UHG2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">General stress protein FMN-binding split barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHG2"/>
    <dbReference type="OrthoDB" id="434253at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052917">
        <property type="entry name" value="Stress-Dev_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818:SF1">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="General stress protein FMN-binding split barrel" evidence="2">
        <location>
            <begin position="25"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2183215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="210" mass="23414" checksum="283B44795E486FC2" modified="2022-01-19" version="1">MTSNVPHADPVREVNQDLNTSPDKKIDDLYHLIEGIPACMMTTRCEKTGKLVSRAMSPRKPDSKTPADLWFFANNTTHKFEELQADPNVNLSFYKPGTSEWISVSGTAQIVNDRQKIEELYEVDIRAWFGDLGDGVHDGGAKDPRISLIFVKADTVHYSLKDRSMPVQMFNIAKGMATGQPPKVSAERDLSTQELENARHVSGLRNAAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHI0</accession>
    <name>A0A8H7UHI0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_006852</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHI0"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF21">
        <property type="entry name" value="EXPANSIN-LIKE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034585231" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="3">
        <location>
            <begin position="28"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2181927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="126" mass="12894" checksum="49AD6A89D2C1B875" modified="2022-01-19" version="1">MVSAKIISILAIAATALAAPMEKRSFSGDATYYNPSAGTNSCGTQASDSDIMAAMNVAQMTNGANPNANPNCGRKVNVKGPKGSVTVTILDTCPGCASGDLDLSPAAFDKIADQAQGRVPITWNWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHI7</accession>
    <name>A0A8H7UHI7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_002489</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHI7"/>
    <dbReference type="OrthoDB" id="361013at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000099">
        <property type="entry name" value="Ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_uS12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2186051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="19949" checksum="ED22BCEC029EA90E" modified="2022-01-19" version="1">MSFLLRSCRGILPSFSTRMSSTPLVVPRTPMAASHSSPILSLLSQNAISQQQRDMATLNQVIRKMRKKTPKLSKTPALDQCYQKKGVCNKVYTTKPKKPNSAVRKVARVKLTNGKVIIAYIPGEGHNLQEHSVVLVRGGRVPDLPGVRYHLVRGAMDLQGVPTRMTSRSKYGTKKPAKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHM0</accession>
    <name>A0A8H7UHM0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHM0"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="80"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2182047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="309" mass="34749" checksum="CCA36A911C06DF26" modified="2022-01-19" version="1">MVSTDNEAEALKQFREALDKETSDKYNDEEQAVQQLTDTVKWRKENNVDEYPVATSENKLPVLYAIRGFELEDANLTPAPGLSESVLRIASYMGGSCLHKTDKDGCPVYIERLGYHAAKEIAKYTTVDEVVQYHIGCNEFLHRVINKQCSAKAGKVINRETVVFDCTGMGWYQFHMPALQYLRAVSDSDQKYYPETMNKLFIVNAPSAFVYVWKMVKGWLDPGTIEKIQIFGKDYKEALLDHIPAENLPEFLGGECKCEHMPGGCVPSPIVGNLPPYVAGEQNPKVTTSYSTEIMEEAKTNPLLRGQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHP1</accession>
    <name>A0A8H7UHP1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_004022</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NOSIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHP1"/>
    <dbReference type="OrthoDB" id="116827at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016818">
        <property type="entry name" value="NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031790">
        <property type="entry name" value="Znf-NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063">
        <property type="entry name" value="ENOS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063:SF10">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15906">
        <property type="entry name" value="zf-NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023577">
        <property type="entry name" value="ENOS_interacting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="267"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="116"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR023577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2180233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="344" mass="38511" checksum="9C9301D0FB273F6D" modified="2022-01-19" version="1">MPRHSKNNTASSVFTYHEVNQLNYGTKKQRLGRDSFRAFNACFLCLQVARDPVACQQGHLACKECMYESILSQKQTMMRQQRLGEQKLREEQEKQVAEEEQAKLAILASFEKTQTSILPDERRKSANESTETSESRESTKEANTPIAASASTGKSLTRIYENSSPTTHAGTKRKFELNSEERQRIVEKETAEAMKKLKEAKAEEAKAKLPSFWLPSLTPSADSTGEKEKAEKIQPMCAASKLHPVSIKSLINVLFTKEDEKSGNAICPACMKGLNNGTKISVLRKCGHVICNKCIDSFVRKSQRCYVCEKKSKDKDIVDMSAEGTGFASNSKNLEAKRFDVAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIR5</accession>
    <name>A0A8H7UIR5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_000538</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIR5"/>
    <dbReference type="OrthoDB" id="6407164at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000064">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000120">
        <property type="entry name" value="Negative regulator of differentiation 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000400">
        <property type="entry name" value="Negative regulator of differentiation 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF8">
        <property type="entry name" value="RNA-BINDING PROTEIN MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="97"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="188"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="317"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="407"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="474"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="488"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2184625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="513" mass="55606" checksum="D4DDC2901A699262" modified="2022-01-19" version="1">MSPNAAAMAMSQYSQASGFAPGMDASNGFSALSQFSGANSMYGSMAGYGTNPMMMNSQFSGMPNSRMAGNYLQSAFPMGFNTGSAMTGSASGSDASRTIYLGNLPENTTYSDIFNHVRTGIVESLRILPEKSCGFLSFLDYAAAQAFYMEFNGGHKLNINGQDVKVGWGKQSSIPMTVQTAVQSGATRNVYLGNLDEDATEEELKNDLGGFGPIEHIKILPEKHIAFVHFANISAAVNCVTSLPTDPKWAARRVNYGKDRCAYAGKQSTSQQMQQGFGFSNPFSFGYDPYSSSRNPQMSGSSMMPQPYMQGASATSTTVYLGNIHPETTCEDICNAIRGGILYQIRYLTDKHIAFVTFMDATAAFNFYQLLNYQGISIKGRRLKGGWGKPVQIPASIIMAVQNGASRNVYIGNLDASITEEKLRTDFSEFGEIELINFLTEKSCAFVNFTSVQSAMNALEGVKTKDDYKKLKVNYGKDRCGNPPRLPKSNSANGESAGQRSSDSQQETTPSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJX6</accession>
    <name>A0A8H7UJX6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_007429</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJX6"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="19"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="459"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2182498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="507" mass="55452" checksum="C8E5323B98538C11" modified="2022-01-19" version="1">MTAVKRSEDQGFLLYQTTCALIAAIAGLNVGWHISVPNMPQQIITNCGIESSGGLPPCLPMTDYVWGLTVGLYAIGGLVGSLGTMFTNMWFGRRANIMICTVFTIIGGILSALAVNTGMYTVGRVFVGIGSGLAGSSVPIYVSEISTKRTRGALGSFFELFLNLGILFTQVAGLYLSKIPDWRFLWVIPSVLALVQLVLLFFFTVECPRRLCANKKYDQAKAALQKLRGDADIEQEFNKMLEARKRDEHRRQMTLWEVISGKDKHVLINTIYVMVLLAYNQIGGVGPMSVYSVSFFTSIFNGDTSMATNLSIIDAAVNIVATLIAVFFMNKVGRKGFMLISTGGMTIACIGIVIGSSVATDKTGPLVIFSAILFLFTYSLGCGVVPWLMIAELLPLHALAAGSALGNSSNWLVNFVENTLWPIINSSLQNYSFIIFIIINFIGFLFCIFCLEETTHKDLDRDHSKPHDKPVDLELEDNSNSAIDKTDNVEHVENMDSPAESTSSDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKN9</accession>
    <name>A0A8H7UKN9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_007324</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKN9"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF1">
        <property type="entry name" value="TRANSCRIPTION ACTIVATOR OF GLUCONEOGENESIS ERT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="181"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="212"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="278"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2182394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="454" mass="50228" checksum="6D05F94948BC37B4" modified="2022-01-19" version="1">MYNQNENVPLVWPNAARRQNDETYRPDDEALSQSPDYGQPYMPIGAYEEYSRYGTGTEPAQPDMGPERSPIVIYPMSQHHPNWDPYRSPSGTPHFTAAAHQSLYQHPGSGRSTYQPYEARPHTQQPSQFTTAESYWATPYYNNSEYSHQSRSHSTPPFYPNLDSGEMTAGVAKPPPYVIKACASCKASHVACDPGRPCQRCLRLGKADTCVDAKRKKRGRPKNSSKSQSSQPPAVTTDSAGSSSTEATPITMGQSQEPPDQLLELNQLLGEYAHQNVQKLTPSEQSSTSNIETHSGASSGQRKITAVSPSTYMQTAGREGQSSIRKQKSLPSSMAVRRGSSTSPVGTPKRRNSHRSTEDVSMPIQPIMLQHHQSVHYPGSQHRQIQQTLPVQDLPSLTGISPETQGYHHMRTSAQTQMPSSSTSHARAIHPLSTQFTFLSDDGESEHQNIHHHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7ULR6</accession>
    <name>A0A8H7ULR6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_002865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7ULR6"/>
    <dbReference type="OrthoDB" id="206700at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF7">
        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="53"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2186427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="398" mass="46178" checksum="F711A7C3D7B68A33" modified="2022-01-19" version="1">MTKRATLRGRRVISNDRYAHENDVYQRIWRINEAIRHDDIGALRNIGRGGGGFVNNSLRRRVWPVLLQYDTVKLGTSTIDNDKEEHSDEKQVLLDVDRSLNAYPEGLDEASKKEKQTELNEVIVEVLRRNKALHYYQPPFLLQHSLTYYYTDAMLDTLDPVLRQVTLLDTLYQHEDHQISDFLQEYVLWLFILLYLMYQWRKTKRAILLISILLPHRANVLPYYCLSWVITWCSHDIDDFSIIPRLFDLFLSSNPLMPVYFAAAIVLAHKEELLQQECENSAVHTFLSKLPQKPLDVEAVVNKATELELAYPPKDLQQQAQIGLDETSSVNTWEDEKLSDEAREKAREILKMEPSERKPRAIVKTNPQQERKIRRMMAAVGALSIGIAAAAMVSARYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCR9</accession>
    <name>A0A8H7PCR9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear movement protein nudC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_008232</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for nuclear movement. May interact between microtubules and nuclei and/or may be involved in the generation of force used to move nuclei during interphase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCR9"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000001">
        <property type="entry name" value="Nuclear migration protein nudC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="6">
        <location>
            <begin position="31"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2171506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="204" mass="23701" checksum="6E957304C3CF0078" modified="2022-01-19" version="1">MSSSEQDYEKMTPKEKEQYDKLQKEKEDAEQAQLPYKWKQTLQDVDITIPVPAGTRGKALDVVIKKKLIKVGLKGQPPILEGELCKDVKVEDSTWTIEDQKEVLVHLEKVNQMTWWEHVVTSAPKINTKAIQPENSKLEDLDGDTRAMVEKMMFDQRQKAMNQPSSDEQKKQDMFKKFQQQHPEMDQGENELINNSIDGIWQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCU0</accession>
    <name>A0A8H7PCU0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008262</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">COPI-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18431at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030663">
        <property type="term" value="C:COPI-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000003">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.20:FF:000002">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046455">
        <property type="entry name" value="Sec7/BIG1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20252">
        <property type="entry name" value="BIG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SEC7" evidence="7">
        <location>
            <begin position="727"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="590"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="668"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="602"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="684"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2171536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1858" mass="208212" checksum="CCD0740630E927B0" modified="2022-01-19" version="1">MAASPSASTVNVSSSRSSLQMQTTTSSAVFIVNALEKIAAAREARRNKQLKEAIQHALDVYKNNEPAPDGQNRFSVILAALQGTISTGTTNLVVIALDCLGKLISYNYVKDEPKAMESVVDLICECFVGESTDEKIQLQIVKALLDAVLSQSNPVHQSSLLKAIRTTYNIFLLSRNSANQNLAQYTLTQMVQHVFSRVNTDAPPPPSAIIVSTPNPTADQDEEGNTPAIDGGVENRTATAAKAVNGDDTYKKADDGEVNEDELKLQSLKDEIIAEAAQARLETVSGTDNSKSPADILGDTEQVFEDHSVPEALAVSSVQVTEDDASKVPTTQVPEQNLESTDEKHAEAEVRKANSDSSNEQEQKEPMTLQSMENRPSFEPESKPIYNSQDDLYAKDAFLVFRALCNLSMKPITTDGNDLKSYSMRSKLLSLHLISIILTAHHAVFTSPGVVLISLQPNGTITATPFIQAAKKNLCVSLSRNAVSVTPQVFDISLEIFWKVVQNLRMYLKKEIEVFFTTIFLPILEMRNASYQQKHSLLNKVVLRICSDPQTLVEIYLNYDCDKEALDNIYERLVNVLSRITTTHAVNVPGKEHPEMRHTADKTQSGQVNGTSVVIPPRLTTDTVQPNERHNAAANQPSEMALKYKSLESLVAVLRSLVTWYNNGAVSVSTNGEDEPTPRESEDQQQPNSAEGLTNHSNTSMPRLSPASSNPLIANGTSSSALDDPEQFESRKHRKQMQQEGVRLFNWKAKKGIQYLHKHGFINVEDHADVAKFLLNTDGLNKTMLGEYLGEGEAENISIMHAFVDEMNFNNMQFTDALRFFLQSFRLPGEGQKIDRFMLKFAERYLDGNPGIFANADTAYVLAYSVVMLNTDQHSPQVKSRMSLEEFIKNNRGINDDADLPQELLEGIYNEIKSNEIIMNDEHEGAASALFTASNSNAGGPLGMVGLQNALMNAGITRDVKGEAYQAVTEEMGSKTEAMFKTMLGGKRRQAAAVGAGAITFYSASHIEHVRPMFEVAWMSFLAGISGPLQESDDTETVNLCLDGFKYAIRTICLFHTIHSEDNMNLQRDAFVTTLTKFTFLTNYSEMKFKNVQAIKALLDVAATDGNHLKGSWKEILTTVSQLERFQLITTGAGVEQNQAGDSVGRRGGRNSASVDLSRRSSNFTTANGRRLNRTNTVITEEVATAGSSHSLVLAVDKLFTSTVNLNGEAIVDFVRALCETSWEEIMSSSQMEHPRMYSLQKLVEISYYNMGRIRLEWSNVWAILGEHFNQVGCQSNFNIAFFALDSLRQLSMQFLEKEELAHFKFQKDFLMPFEYILANNQDVAIKDMVLRCLTQMIQARAHHIRSGWKTMFAVFAKGACESSESIVSMTFDIVRSLSNERFSDIVANGTFPDFVSCLSEFSKNRKFQKISLPALDMIKSTVPRMIGLAEQNQTIVINDANAAAGRVVQSGEDFLIKFWFAILFGFKEVTMKSDDVEVRRRALQYLFEALKEHGATFSAEFWNTVTRQIIFPLFEDLRPDSEHQRTMSDEDFSVWMSTTMIEALRSVVDLYTFYFDNMRDMMKHVLSLFSLCILQENDTLARIGCECLQQYVEANVEKFDESSWELVTETFVDLFDKTTAQSLFDDTQDLLERSRQNPDEVFSVSEERQRAFSHIIMKCVLQLLLIQTVNDLLSKDTVYIAFPARHLMVVMDCLGQSFHFAERFNNDNELRMALWRFGFMKQLPNLLKQETSSGACYVTNLMRMFANIENIEDRDERREDIEKTLIPLCNEIFALYSELDHETKPKNIAAWTPVVVSILSGLTNMQDQDFLKHLPQFYESSINMLAQDNLIPEIRVVLRTLLLRVGKAYNISSSTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDK2</accession>
    <name>A0A8H7PDK2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_001408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDK2"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2171932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26413" checksum="22D43406FAA8250D" modified="2022-01-19" version="1">MAPLEIIGTGWSRTGTAGMREALLALGYKVSHMLDIVSDPTIDTSVYEEAWNGKDVDWNRAFANYNASLDWPNATFYKQLMEKYPDAKVLHTTRDPEKWYESVVQTVYATTRKYSVEKDSCPPGVLEGVTAADEVVFNGYFKGEFLNKEKTIQMFKDHDEEVKRIVPAEKLLVFETGVDGWDKLCSFLGKGKPDTPWPHINSREDFQVMVKDLEDKKELKNLTMPHDIYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDQ1</accession>
    <name>A0A8H7PDQ1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Membrane insertase YidC/Oxa/ALB C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_001496</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDQ1"/>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF66">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="11">
        <location>
            <begin position="134"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2172019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="393" mass="42615" checksum="FABD2B522E522B44" modified="2022-01-19" version="1" fragment="single">GRTAGPTPVRQMSMLMANRQSVISLRSQLPIALSQTSVRSYTTPTAETVTTDRANVEAAAVTPANITPDAVAAASENITHDVADVVSAAPTSEAVSAAVAQIGDFKAMGLCNYTPVGALEAALEAIHVTTGLPWWAAIAATTVAIRTLMLPLMVKVQRNNARVANINPDLQRIMNNVNEAKKSGDQMAIAKYSQQAQQLFKDNECHPAKSLLLPVFQAPVMISFFMALRGMAELPVPGFLDGGLAWFTDLSVKDPYYVLPILSSAGMLAILETGSETGAANPQAAGMKKFFRGMTILMIPFTAWMPSSVFVYWVTNNMFTLGQFMALKAPAVRSALNIPKLVKPAAELQKNTKGFMETFKEQTASYQKTEKERIVRERQQAAAMARRANKRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDQ4</accession>
    <name>A0A8H7PDQ4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_001509</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDQ4"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF37">
        <property type="entry name" value="AMIDASE C869.01-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034948787" description="Amidase domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="61"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2172032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="551" mass="59913" checksum="C74DF55C91372DAC" modified="2022-01-19" version="1">MQSLWPAFLLALVCLITLTHAAHSVHTPFPMPTCHGFKLEEASVDAIQKQMSKGKLTSRQLVQCYLDRINSVNPYLHAIIETNPDIYLIADQLDKERAHGKVRGPLHGIPILVKDNIATDDRMNTTAGSYALLGNVVPRDAHVIALLRKAGAIILGKGNMSEWADIRANSYSEGWSARGGQTRNSYNLTQDPAGSSSGPAHAVSANLVTVAIGTETDGSVIAPAQRAGIIGIKPTVGLTSRDGVIPEAHSQDTVGAFGKTFMDAAYVLTAMHGIDPRDNATYAQQGHASPDYTKFVSKKSALKGVRIGIPWKRVWESSTTVNQYPQLFSAIAELRKAGAIILNNTDLPDIDQITPNPPGWNWQFKNGLGLDNESEFTVVCYEFKQNLNQYLSELVSSPVRTLADIVKYNDDHASVEEKYFGQEVLVQCNESPYSEETYLQAKAYVDRTTRAGGIDAALKKYKVQALLVPSDNFSPSTEIPAMAGYPMVTIPAGIDGWGVAFGIGLWGTAFSEPTLIKLGSAIEDTLRRRQVPTFLDHTATNIPINSEIGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PE51</accession>
    <name>A0A8H7PE51_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PE51"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00083">
        <property type="entry name" value="bHLH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787:SF1">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="272"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2172248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="442" mass="48609" checksum="D7A68BF0617F4BAE" modified="2022-01-19" version="1">MTPGAPKNLSELQTKSVTLESLAPPHKKRKSKTQVDNSVSQDPSKVERHSKLNAIKSSVIYPLTPSPDMTGKNIRERIPSISLPPGIISEKLTQTPPSSPAISATDDTMPTKYINTSELPRPTLPSTFNPQVPIHPHVIIAGTSPAMYYHPNQTAYYQSGPSDPNIQKNITSSDTKKASNDADSSEASTGTDQLSHKAAATPSSLMPGMPSNMPAFAYLAGQPYSYPTYMVPGGSMPGYSMVPHMSPPLHPSITSSPTGGRRGTTADQREQLRKVSHSAIERRRREKINVKIQQLRQLIPSCADQDHLHKLNILQSAIEYIGYLHEVLRNMETDDGSSVLELAARNDLRMLGVLQHLQRLSPTQAVLSSPSTSRLLSDQNRSQLPCEEETQMISKRKAEYMEHDESAKAGLMMLSQAISRGAQEDENPKHRNMHLDSLLCEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PE53</accession>
    <name>A0A8H7PE53_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Brl1/Brr6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_004800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PE53"/>
    <dbReference type="OrthoDB" id="5961at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040202">
        <property type="entry name" value="Brl1/Brr6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018767">
        <property type="entry name" value="Brl1/Brr6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136:SF1">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10104">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01042">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Brl1/Brr6" evidence="3">
        <location>
            <begin position="187"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2172259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="349" mass="39337" checksum="BAC0D1FDF3758EB7" modified="2022-01-19" version="1">MYRSRAGPMDYEYESKSELPNIFARKEKEPLITEKTEVETGVKRTFSSAGLSTPSPSFTFQQSPKDVKPYVSGLGHPFLFALPNSVAKEADVPDNTVAASQRKISQNAVLRARKRRAKENLFGSGFRKRLYEIAGENESASDSDSDTFDQKPLAANAENGKPMTENQASKTEFDGWNAPQYDYAYIISGYIQTGFNLFIVLVMVYLAVQVILTIQRDVQQKVDEYSSAIVKEISVCAKLYYDNRCDPENRVPAMDESCRNWETCMDRDPDIVGRAKVSAETFAEIVNGFIDPISYKSMLFFLVLIFGSLIISNCAFGMYRSRHLHQYQELVNTHVGGAYGNSNLKSHRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEF5</accession>
    <name>A0A8H7PEF5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEF5"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF63">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2172410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="47986" checksum="4AD76C4089B8E9BE" modified="2022-01-19" version="1">MVINMVDKSQKSTDMNLIWNVYYDAQRLNVPLNTVIYNTMLQALLKRQDHTQVHRVYKEMLDGGKQPSLYTYGMLMHSMSKQGDMAGFTKMLDIMQGRNMFPDFVGWSIIMHSLGRHGNSDGVERIYEFLIQSKVPINSRIINERLHAIICQKLTRTWTRSHRLNQLDKIWKEHFGVPPTSQDPVEYPRIKPDSASYTIMMKALSFDKPSKALSDIPKILQVMEQRGLQPGPLALIHYTSACLDCKDTVKAKEAISLFRDRYNVLANEKTWRRVLGSMASLQDISGIFWALDALTESKYVNHEPTIDRSIPRKRPARYKNEIKLQESHVRSPPNSFLNAVFVPKTQELLFTALLKLDTPIIERSATEHSNERVVMVWNKLSSSGVYIPLKVEQSIVVPGLLASGMHMHDIRQRIVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEP9</accession>
    <name>A0A8H7PEP9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_001422</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEP9"/>
    <dbReference type="OrthoDB" id="1898734at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF2">
        <property type="entry name" value="PROLYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="153"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2171946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="542" mass="61262" checksum="4B268DE29DEDE1F4" modified="2022-01-19" version="1">MVSTSKRAPHLPDARSGTTTLQTHAGASITGITPLQVVKIFPNETGFMFFDVLFRSYRSSIVYTKLPTRFPQRGFGFYTNAHYRTISSKMQVNYLDKADVETFTLPGAQVYEHYFDLPLVHNNASKDKRRIKVFCRQLVPIEKVNERKTLPFFLYLQGGPGFPCSLPKISGWIKVAFDHGYQVLLLDGRGTGLSSPITVESLDSFSDQEKADYLKYFRADSIVRDVEAIRSQLTLNRDPKHESKITLLGQSFGGFCITTYLSLFPDSVKAAYITGGVPPLVNSPDRVYEKTFARILKRNDIYYEKYPSDVKRVQDIIKYLNKDAVKLPDGGTLSSRRFLQLGLAFGGSGGYDSVHEVVVHAAQDLDMLGKLSFTTLSSVQKMQDFDSNVIYAILHEAIYCQGAASKWSAERIRMSDKFQPAFDWSGGSRVNFTGETIHPFMFDDYSQLAHLKKAAHILAEYENWDKLYDVEQLRRNAVPVAGVSYFEDMYVDVDLSIETANTVKGFQSWITNEFAHNGLREDPERVLGYLIKLSRGDHGSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEY6</accession>
    <name>A0A8H7PEY6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEY6"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="274" mass="32808" checksum="878EA98391450D0A" modified="2022-01-19" version="1">MYAEAQKRSQRYLKYAMREYRKYRIRHQRYMESNLCKAITKKGHRCEVVTDSTYCNVHKHLDSTIKEETPVLKKKLDVTAITNDLMHKYHNVESREYHGDKSNPLKHNKVRDAYRDERHDIERVYRKYINLAATSDDLDDIYERVDESIKEIRDRTDETILLIETEEDTSELAKIIAELEKEKSKLVRREYKGPMQYPHVMKMINDICNSELKAKIDIYEGIASAISFRDFETEYDEIQEFLSFVKPDIKQIEKKTEEKLKAVMPRKKNPSKHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFA3</accession>
    <name>A0A8H7PFA3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_000163</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFA3"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="9">
        <location>
            <begin position="648"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="308"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="556"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2172813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="724" mass="81253" checksum="E1FCF197CCE45765" modified="2022-01-19" version="1">MTASVASAHMDFVHPPVPGQVHKYYGSVHNAHLLLPSITTVDQPKPKPQPVTKKRESASLYTAASTGNLQQLKDLLNETNQVNQHQPVTGLTVLHFAASRGHLEVVHCLCQDYGALTDVEDREGETALLKAAYNGHFPIVQYMVQDHHVNIHHKDKDGWTALHNACSRGHSKIVRFLVERGARVDVRSKMGHTPLINAASKGYMSIVEYLLEEAHANPLIKNSFGEAAYDVSAAAGESYICEMLQKAEKDWWARGPEHGIDITVYTKGKVYDPLEFHVTVTSILDENQRSSSVLSNFGLARPTYSAAALTKADSRRPWTDHTTGEPKQKEDVKLPSPSTSSPGNSHWFWLTDWQIDYSDPRIDPTSGWQYAKSFDVDDDRWTPVAPGSGAGWVRRRRWVRVMKRRMDLVNGGHQGNEDALILSENARRQEEEDEQGDKQDYLYRAEAIVRKMVQQSQVSKAQPTAQKQKAAIAHDLRATTQKLRSYEEAIQILLAGIKSDQNQRRKKHASNLVNQYLNNADKLNKEIAELAPQLSTPITPSPIKRNAELERELGFFDQPNRSESTNGSPALNENNGASTDRELDNNPWSHSRETSVLPIGRLTRSNTSQSAASMFGSSRSVGSASISQVFEPLETEVELPRKFEWEPDHLANECRRCDKRFGLLNRRHHCRRCGLVVCDKCSTARTFLPSNQILKDPNASESMQNLSSQHHRVCDKCYADLGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFP5</accession>
    <name>A0A8H7PFP5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_004469</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFP5"/>
    <dbReference type="OrthoDB" id="16982at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000014">
        <property type="entry name" value="Cation/H+ exchanger protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF10">
        <property type="entry name" value="VNX1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="603"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="768"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="806"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="838"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="872"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="900"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="domain" description="Inner membrane component" evidence="12">
        <location>
            <begin position="196"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="436"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="767"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2173096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="938" mass="104339" checksum="975F34A4091FAE1D" modified="2022-01-19" version="1">MADPANQESSQRNPSSRRPSSAQRATSTSIHHASKKSSTRYRGSTSRQNSSSNLMPSRKKIKRSQSSRRHISRQQGSETSSIHSSASRASGSDSSRNYRPSGSRRHSKGDDNGSNNEDEDGEDVHDGREHGEEEEEDSDREMTLKDRQDAINKSHPFGLPIWKPALYKKSRSVVRRANSALHSAPTTTPEMFLYPGNILWAIIFGWWLAIVMLVLSLIMLLVPPDGYKYASVLRGLANYLFWPFGKYVQRAVDTEPESLSNYRVSSEPESQEDSDVDEDLGLISGRRHKRRNYLQTVKENTIELIRLGPSGWIFYLLFYTVLAPLQLFVSCICWGCVITIPMAKLTYVLTRHLRRHPLSLHFRSSGSTLMPTSSTAHQRTVILLCTYQAIGLQYYKYTYDGINIIFINLLPVCFFVIFDEYVLHKYFPDAWFTKPALVFLFGLGSVIPLSYFIGMAVSSISAQSSMGMGAVINATFGSIIEIILYSVALMSGKSALVEGSLIGSFLAGVLLMPGCSMLSGAVKRKEQKFNAKSAGVTSTMLIMAIIAALSPTLFYQMYGSFELRCSGCPESPPQTDIFACSRCYYDQMNPANDPVYQNSVKPLMWICALVLPSAYFIALVFSLHTHADMVWSSSHGHHGTEESNYRKLLPTHIMSQLIHLSNNQAPPVHLGPNQSQAELGNGQGGMVDTNSPINLPYNTSHVAVVTTSPIRRPIHGDDNNIESSEMLPETLGQPVAPVTWVHAKEPEEEEDEEAAGHDSPNWSKSKSFTILFGCTILYSLIAEILVDTVDIVMESLAIDEKFLGLTLFALVPNITEFMNAISFALYGNIVLSLEIGSAYALQVCLIQIPAMVGFSLWYNWGMGDVAKYTFTLVFPRWDAICVVFSVFLLTYTYQEGKSNYFKGSILILSYFVLMAGFYLTPPSASHSVLDGVPMVMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGN6</accession>
    <name>A0A8H7PGN6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGN6"/>
    <dbReference type="OrthoDB" id="2206081at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="352" mass="40354" checksum="2F89AAAEF1BAA1AB" modified="2022-01-19" version="1" fragment="single">MVELSPYGTRVVDRINMILMFTACLVCVRNALVCIKQYRRTKGSIHLLNLAQVVVLFIHRLVYGCIPLFEITNCAIFPFLVSMWHITYLLFYTVMLRRCLILESSQYSRLIKFTGIFLILVRFADWPYELTFHNIQAQMDLPIESGQTCWATWGSGVLILNFIGDTLANLFLSGLFVRSCNTDNHDIFRLYKHLQIQTNMIVNQRSALVEYIARKSLVCLILTFLVNLIMNLLKITNFLGDRSDAFTPFFEIVESTLLVEALRVDHENLKIHQNFCESCGFVIAASTGNGGGRNGRRSTNTRRPSSLVRVLSNTTCPTDLDIAKPEESFTVTMNSIHHDRSELHDRPEWNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGU4</accession>
    <name>A0A8H7PGU4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_005078</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGU4"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2173658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="110" mass="12614" checksum="19327D9556A22858" modified="2022-01-19" version="1">MGLKYRTYLEGRKVYGCQNCRSHLANSDGLISKQFQGQHGQAYLFRYVVNVSEGPEKEKQMTTGKHTITTVFCCQCDTEVGWRYIKAYEESQKYKEGACILEKALLTTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGY3</accession>
    <name>A0A8H7PGY3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_005224</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGY3"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2173804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="319" mass="36014" checksum="41B667F7B98CA4C6" modified="2022-01-19" version="1">MASTIPVAKLNSGYELPVIGYGTYGGPNAPQEVYEGSKIALEMGYRHFDTAYNYNTEASLAKAIKESGIPREKLFLTTKLWNTFHEPQHVKPACQKSLEKLETDYLDMYLMHWPVSWPFNGYECEYDTLRPWKDGKIENLGVSFIDTYKAMEQLVKEGLVRSIGVSNFTIPKLKALLEHCEIPPAVNQVELHPFLPQEELLSFCKENNIHVTAFSPLSNPGIVKGKNRKTSLLEEPRLIEVANKYGKSPGVTALNWGVQRGYSIVPKSVTPTRIKANMETFPMAQEDIDYITQIGRDNPIRVCNSTLLWGPEHAAFDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGZ6</accession>
    <name>A0A8H7PGZ6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGZ6"/>
    <dbReference type="OrthoDB" id="275457at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="379" mass="42555" checksum="8A5FFB74A9D43BFE" modified="2022-01-19" version="1">MLIAYKDARVLTTTYLTQRLIHDLMLRRKTGQPFIRQGGGGRSTSNGHIATVFGCTGFLGRYVVHRLAQQGTQVVVPFRDSEEARHLRVTGDLGQIIPLEFDLKNRETINECVRHSDIVYNLVGRDYETNSITLVARNFSFDQVHVDGARAIAEACAENDVARLVQVSSLNANEDSTSAFLRSKAKGEKAVREIIPDTTIVRPGTMYGQEDRFLNRIGTGEGWQFWVNESQAKIRPVYAIDVAQALEVILGAESTMGKTYEFYGPKEYSYQQLFDIAREISKKPLPTYNLPTSVAKLAASVLDKFPYNQMISPDLIERMTLDDKPTPGALTFADLYIEPTDLDAVALQFLRRFRSTAVFDLPYEKGEGQVKKGVYHVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PH93</accession>
    <name>A0A8H7PH93_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PH93"/>
    <dbReference type="OrthoDB" id="18339at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019138">
        <property type="entry name" value="De-etiolated_protein_1_Det1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13374:SF3">
        <property type="entry name" value="DET1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13374">
        <property type="entry name" value="DET1 HOMOLOG DE-ETIOLATED-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09737">
        <property type="entry name" value="Det1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2173236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="389" mass="45025" checksum="5064D1811F03B924" modified="2022-01-19" version="1">MSDGHFRKLRSIGWFNDETEEDLLQQYILREEVYREQKSHTLSDRGVKRSATAADLTTEEHDEHVYMPDSTARTQPIPRLLEVHPNLVNEATLDDMTDLDVDEGDENQSGKLKESPGLISGFRQKFMTYLYRKAVNERDGGISLRHFYCNFDAFASMKLWRVQLLSGHKLLVKLNNVTHALGRQAETSMQMAVFVIYNMATTEVETVFDHSSSSVLEFYEGHADILRGLPHEGITWHGSSYINSEVVKDSLKRQMYVWRYAMNGGRAEAMRRMSLSLPQCPQSYLECPYFDQSLFNFDEKYVSSLDGPKSSQNSPIKFYVRQNGRMKFKIDPNPIPFVNRRDTSTARRFTTFIPHPTLPFIISKQHSMMRPTIVNFHVYNEQADLKYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHR5</accession>
    <name>A0A8H7PHR5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_004248</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHR5"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF26">
        <property type="entry name" value="OS04G0435100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2174227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="521" mass="56670" checksum="A5CE96A5F53C1C97" modified="2022-01-19" version="1">MSDKGKTEVSEQEKSNEMATETPNVMHIESNQLDYDAQRLHDLGYKQEFSRSLDMFVQFGFAFSTMAVLPSWSVGFGPALNSGGPTTLVFGWIVVATFVSLIGLGMAEIVSAMPTAGGVYYWCFKLSNEKYGPFAAWMAGYTYLIGLLAVNMTLAYGGAQFVIGMVGIGTGNFAQPEGAYVGIYVGLLLLAGAVNLLGTKVTGIINKFIVLWALIGTAIIVIAMPVMAPTHQSAKWVFTEFINNTGYQNSGNVFLLGMLQAGWTLIGYETSAQIVEETHRADVAAPRGIIVSILGAWIQGLVLIVAVLFSIQDVDTIASATVPIAELFQSTTNNPHLAIFFLFILLGAQLGSLFNSILACGHLIWAMARDGCLPYSKFFYKLSKGSHTPVRAIMLQLVICIVIIMPSFATTVFWQAILSAAVIAVNISYGLPFLCRLLFTRNVPLDGPFRLGKFSIPLNIISLAWITFFAVILCFPSVSPVDAQTMNYASLMIGAVLLFALFFWFVSGRHFYKGPMQNADH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJ93</accession>
    <name>A0A8H7PJ93_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJ93"/>
    <dbReference type="OrthoDB" id="2350333at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2174760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="274" mass="31141" checksum="4F2031EE9574D525" modified="2022-01-19" version="1">MSSTDTEPCWNTDTDDVDSGGEGPIVVEDALEDQFRSEFSEDEYSEGVAAKEQDVELGMENDDVYKEVHMIVQRTREGLSKKKNILHPMRYGIVDLTGRHAPSQLVLHPWGEITLNASAERRNKTCDPEVRARIGQRCDYLLTYKGHAMCPEVLIGEVSGGIPAGANWKTCFQLSGFRLTIYAVGFFHGMWRVMMLDECLLPISNEDKESRIKVYSILKGLMEAARAEANVIRRMLNSDAYSLEADDRRLFRKREKDDISNFSGTTWTWPFSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJH2</accession>
    <name>A0A8H7PJH2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJH2"/>
    <dbReference type="OrthoDB" id="2402171at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
        <property type="entry name" value="MMS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891:SF0">
        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MMS19 N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2174988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="356" mass="39522" checksum="B9D2051029B495DC" modified="2022-01-19" version="1" fragment="single">FYEIAVATRTDEFIPKFIQAMDGERDPRNLVIAFKTLKLMTRLLDVSKCIEDLFELLWCYFPITFKPPPNDPYAITTEELKRHLRECIAATPYFSKFAMPSLQEKLEHPSDTVKKEAIATLTLCAPVYGAHALLPGISDIFNVLSSQIFYAKDGDMQELALNSIHVITSTLATGISIAAISNPIERSLDPLIDECMVALKQPEHKNARSAIAILRSAASASDPACTAIVDRVIPSLLAAYQNAHNDGERIAILDLIIEIMDASRTLYGTMDGLKGILSVTFKQHKVHLTYSISTVDRDFMTPLLAYKPHLLTLYVQVAKSSTDILQYKGCHGLYIMAASRHFLTDNEVSGVVDILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKB0</accession>
    <name>A0A8H7PKB0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKB0"/>
    <dbReference type="OrthoDB" id="78947at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045108">
        <property type="entry name" value="TXNDC17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452">
        <property type="entry name" value="42-9-9 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2175607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="128" mass="14507" checksum="4BF96AA62803C78A" modified="2022-01-19" version="1">MIAQRVPLEEFDQTLQQTVAQNDKVFVLFFGTEDPVNNNESWCPDCVIADPLVRKWVNKVPDSVLLEAPVGTRSEWKRNSEHIYKSNPLIALKAIPTLIRWTKDGPAGRLVEDECADQTKLEAFVNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKM5</accession>
    <name>A0A8H7PKM5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKM5"/>
    <dbReference type="OrthoDB" id="2329609at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018814">
        <property type="entry name" value="DUF5427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10310">
        <property type="entry name" value="DUF5427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="787" mass="87962" checksum="D8C1FBCB9EB31087" modified="2022-01-19" version="1">MSQDNGETTNSSLTAAQQFLDSIDADVGLSSADGTSETSTQPSKPADAKEIMSFIDEWTTTPVTADNDLPEKKEQEVQQPKTSSVPSSGQQAAQIDSGAGWASWGTSLWSQASAAVKAGTDQINKVTQDSETAKLFEGRVNDCYVIWVLLRRSADTNGHKLQGSELRNLTLTGVNTFLDTVAPPLSDEEIVEVWLSKGQLGYLGLEQITYRAWASLLEQTATGDIVVQTDDKEISNSEQSTGGAFTIGLHKGLAVAKAAAKEDVQALAEKHPFVQPVDSSEANGGQSEESHNEIRICPVYLSVQATNLDLVEEQNNQMAFTLLLSDPRHKLEFQGLSQSIPKRWLEIPYEENEWRVVIMLVVLVSATVSLLLLYSTGSSKSIFFSSQSEIDALSKLQPAHYEDAMPDCMANTATRDNITATKEQWATCLDGGSQSSAYLSIVIVTRMDDYAGMSHLAMIFLNATDLLVETWAVLIWKFHPIATFFGIKGNQFHRFQNFVNSAYLLAEHTKEHIELLIIEWNPPANTRRVYDVLRFRRSKYLSYRIIAVPKALHNVIPNVGNAPLHEFEGKNLGIRFARGEYVVCTNQDDIWSVNFHNAIKSHYFKQGIIYLQHQDRHNIHDDLPPSIVRLPSYPDDDTLYNACVPTPQDWGNFKSRGPINVNLDNILQVADQAGDFTLAHRDTWKHARGYRETGGVAWVDIEFVCTAAWTLGLEVEYIDETFACHQDHPNIWETTPERHTDNTHIDMGEIMRKEKVYINDADAWGMQKIDIWHYGLDCHQFGGGLCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKQ6</accession>
    <name>A0A8H7PKQ6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUF914-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_001353</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKQ6"/>
    <dbReference type="OrthoDB" id="429955at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052221">
        <property type="entry name" value="SLC35F_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233">
        <property type="entry name" value="DUF914-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2175706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="44219" checksum="C34E71552AA33D1B" modified="2022-01-19" version="1">MESEKTKWQRLVDYVKAPEIPPSEKKTWKERLMFLKDPKFLKVLLLGQFLSLCITGTNVTTTLLASNSMPTTQTFLNYLIVAVVYNSIAIYKRGFKGWLLQFWRRGLYYFVLGFIDVEGNYFVVKAYEYTSLLSAMLLDAWTTPVVMILSFFFLRARYRWLQYLGVFVALCGLGMLVASDVITGKNYAAADALKGDLFCILGATLYGLSNVGEEFMIRKHPHYEVVGMLSFFATFINFVQLMILERNEFADFSKSSFSIGMMLIYTACMFCIYSLGPIMFRMAGAVVFNLSLLTSDFYGLIFGLGLFGYSVTFLYPIAYVVVIVGIAAYHFFPVPEPGIGGFDKEREEQERRELFGIKSEDVERQDVEHIEEMSDEALTPELSTEGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLS3</accession>
    <name>A0A8H7PLS3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial phosphate carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_005631</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLS3"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000024">
        <property type="entry name" value="MIR1p Mitochondrial phosphate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF12">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="28"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="126"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="227"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2176397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="34081" checksum="8798461410C38099" modified="2022-01-19" version="1">MFPSQSALQKNFVAASPASDAAAPTGAALYARFAFAGAVCCSITHGAMTPVDVVKTRIQLSPEIYNKGMIGGFRQVIQAEGAGALLTGFGPTAAGYFLQGAFKFGGYEFWKKTAIDVVGIDNAVQNRTAIYLGASAIAEFFADVALCPLEATRIRLVSQPTFANGLLGGFSRILKEEGVLRGFYSGFGPILFKQVPYTMAKFVVYEKAAEAIYKSIGTPKELLSNGTVTAVNLGSGIIAGTCAAIISQPADTLLSKINKQKGVEGQSITSRLVTMAGQLGVKGLFTGLGPRIVMVATLTAGQFAIYGDIKRVLGATAGVEIAPIPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPD7</accession>
    <name>A0A8H7PPD7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPD7"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="76"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="291" mass="31595" checksum="EF6F9C9498ACA5AA" modified="2022-01-19" version="1">MTAEEEAAPNLEALLTMSAPELRATMIALREKQTAHCPPPKLEEPANITNSDFRGPESIVPVRIYTPKGSGPFPCIVFYHGGGWVFGNLDVYDSLCRAMCVGTGAVLVSVDYRLAPENKFPAAVEDAYAALLHVKKNAKIYNIDTTRIAVAGDSAGGNISAVVTLMTRDRKGPNIKFQCLIYPACDFRSTAGQHSAMLQHKSEDADNIYASPLKADLSGLPAAYLLTCDDDVALRDEGRAYYEKLEACGVPCEYVNMEGLSHGFFDQNKHQVPAIAKYQDDAFLAIKKGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPJ0</accession>
    <name>A0A8H7PPJ0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_007856</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPJ0"/>
    <dbReference type="OrthoDB" id="2534523at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001238">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF34">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="7">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2177199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="305" mass="34224" checksum="3ABEC97DB9220993" modified="2022-01-19" version="1">MHLQLRWSTKRVPNIGIKLSYQEWTKISVDIENTSATIIELESQVYEEMCETVLRQTDSIIRSCRAFSQLDVLSSFARLALDNKLVRPSINDHNAIQIIGGRHPVVEASLYQRGRQFIKNDCHIHNKETVWLLTGPNMGGKSTFLRQTAVILLLGQIGCYVPAKQANIGIADRIFSRVGASDNLAQNQSTFMVEMMETANILKNATSKSFVIMDEVGRGTATHDGLSLAYSILHYIHDELKCRTLFATHYHDLADMLPTDRFNRLACYKTTIEEDAGGGYIFNHRITPGVCRKSHGIKVAQIAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQB9</accession>
    <name>A0A8H7PQB9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQB9"/>
    <dbReference type="OrthoDB" id="2403244at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="489"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="557"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="672"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="221"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="394"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="683"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="698"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="728" mass="82742" checksum="CFC85A0EBDA63BE8" modified="2022-01-19" version="1">MQRLDEYRSKKGEVKLNIEYAYLGITDDCCYDLRSDRRLKNDIILDNGIDTVIKPVDNVDLIWDRVKLGSKFPFVLKVRLSDNARFLGNFVITDLLTTRFVASSTRTKDGYAFHESCSRLRETVRLIATSNHMGLIPSDACVLTKALAQYLSGMSRMNAFIHVEEYPETALEETLSALDFAQHLQQITCRSLRNVVDLRVADSGSKAEYYKDRFYRAQALVNKMETRCEELQSELQESKKTLQSTSNLEADIKHDLENSATINAELQSRNRSLELETEYLKHHVELFKAEFQDQIRQLQTEAGMLKHSQRRAICEAEDLEEEVKEKEQIIMELTATLKTRAQQVEDLEIFQKQAKLLLNENDGKYAKMVRFYERKEADFMEQMQHEKFKWSEKRSIMQSKIDNLQHELEKSRDQNFKAQQDKMNWISNQEKLQAQLTQLMEEAKAATTRSNSVAGDNMNAAVTIQDISNLRFELERQAKELEGYKAQINPVETTTGGKSAREQREIPQTTSELPSYAKQHEVPELEHVQHSIAQASQMQGSDTEDSAPVMVAKENIQPTVVNQQDRSNESAPKINKDKEKADKSSNKRAKISSSQVKYTSTESQTTATKSIALETTTDNAPPPASTKTKQAGNVHEPTTDAFQDNVGRARVLSPELLVYPTPKQTEPLSAAIASTGAKPTKAINPTKTPLQEESTAKSSRKKRKLGSRKTITAEEQKALIEFKIIPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQF9</accession>
    <name>A0A8H7PQF9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQF9"/>
    <dbReference type="OrthoDB" id="204058at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052562">
        <property type="entry name" value="Ketohexokinase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774:SF3">
        <property type="entry name" value="KETOHEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774">
        <property type="entry name" value="PHOSPHOTRANSFERASE SYSTEM TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="3">
        <location>
            <begin position="10"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2178196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="325" mass="36580" checksum="CD9E6F5E3BE9A54A" modified="2022-01-19" version="1">MQAQQPESQAKVLAVGQLYQDFILHVDHFPEEDAKKRANNLEIRSGGNCGNTLRVLSQFPGVSAWCMSSLGSKAEAGGLLQVLEDQHVHTSTCVFHDHGLNPSSYIIHASDTGTRTIISYNKTEDLTLEDFVAKVEQASTDHKFHWVHFEGRNVNNAVKQIEWLDNKALHEGWRNQLTISVELEKPDREDIDSLLDKGDVVFFSKLFAERRGFNQAHEFLKAYAERCQPHALIFCTWGAQGATCLHRPSQELFESPSIPIEQVRDTVGAGDSFTAGVIYGLSNKWSVKDALEFSCELAGRKVAQSGFDRLYEQMIPSLQRFSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRV3</accession>
    <name>A0A8H7PRV3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRV3"/>
    <dbReference type="OrthoDB" id="5229808at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013248">
        <property type="entry name" value="Psh3/Shr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228:SF1">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08229">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00786">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2178096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="160" mass="17345" checksum="B3B20ED6AD7BFF29" modified="2022-01-19" version="1">MSIIQDLSTIKVAMIVSACFFAYGRYWADWVFDYYILWSDPAGRQNAFSNAALYYANQNDTPMVHQYISIINIGIASVGLLAGLASMRDANILFDGASLVLMIFGLTSHISSIRPGIELIATSKDDEAIAEALKGIAAAHTVIVTAVTGKRQMDGLSFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PS25</accession>
    <name>A0A8H7PS25_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_001731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PS25"/>
    <dbReference type="OrthoDB" id="10302658at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2178885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="799" mass="90718" checksum="0E08A8474D3CEA9A" modified="2022-01-19" version="1">MDLTQFYSRYTAFVSQIRVPPVMAQHGLALLQRCVDLEHCDVANLRLRPDVVHVDPRQCRCENMVYFLLKRPGGNVEYRALDSNVLVSGDTMVYAGQTGNYVLRERARRGIMRNSTLMLCFGHDLTQYQQDCLELAAIIFSFLVFGLRTRNVSPYPKYVYYDIPASISIDSVEDHTALQRTNTYQLLRHTTFVGTAPSSRIMNRQWYTDSLQNATNPVFDWDLVALASPSLARLLAFLTHGNESIAAPPFIDHFPDISSEKYDDLSIHLTGTSQRDYDRKVRETAHRLNSRVIVMFGGRPTQMIDTVHRNRFLATICSRVDLNYISPQTCSFIMWWPHFGIESHASNVTKVRLSQVWQLLSLKLNLLLWRLEAESFGVHGLDHVTAQSIKEWVNGLPMSQQLSQLLIEVSVNWMSTNTGTLSEFTELSTEITESNTTPPAIDDPVILGIPNMQDQVTFENEASTSTASVLQSDIDEASTSAAIVVLSDIGEATVIDLTTENEVVDASALPNTDQDHLDDHFQGWARSTETQTMNRTMRRVPNFLVLPRVEQLRELTRTTQIWNATIRQTRLTRSIEAGEFVPRDGETNEDQLTRFQRHINMERVRRSHVPTSTLFTCVYCNQLINKTLTKVGKVHVPTQPENCPNPPSLKIGWSIVRGEYGGIFPDENIFTLFAKAQDPGTVLNQVELGKRVAIFCHNNGWHPQVQHLLEERYYPNWGRVMAMYATEQDPGSVRSGWITGVKEAMEKVAHTQPVVIVKRQKTMREGFKASHSKSSNTMSVYAFEPASNDREDILSLEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSG6</accession>
    <name>A0A8H7PSG6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UVR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_002111</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSG6"/>
    <dbReference type="OrthoDB" id="2416276at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045111">
        <property type="term" value="C:intermediate filament cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026081">
        <property type="entry name" value="DISC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14332">
        <property type="entry name" value="DISRUPTED IN SCHIZOPHRENIA 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14332:SF3">
        <property type="entry name" value="DISRUPTED IN SCHIZOPHRENIA 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UVR" evidence="3">
        <location>
            <begin position="728"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="322"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="445"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="598"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2179261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="773" mass="88104" checksum="554849CD54047FC0" modified="2022-01-19" version="1">MQSDDFYEENEQPRRVQPTSRTNSQVSSPSRGGFLSGFSFLRDGFANGSSSAGHSIPSSPRGQSPRPKVSTSIDFRSTNTSSESRSPSQSAFAFIAAGSPKSHDISQKRESGNNLSKVQMRSSQFSFIEADLATPSSELAFAIDSRTNSPSKKRSSLPMAPPSASVATSDPSNLPKVTPKPHDYERQKVSSESALKRIQAETNRRITMLSNVFGKQAKTYSQLEQLYGALRSLESKEQQCLDDEDFVRADSLHTEWEKTTKHIEFLESQSLKGLSDEFSNTWHNLSNLMRQEAEAASKAAEAYVAVKSTREQGLEQYVTDTNNVQRQKIQEIMEQRTELEKEKSENAFDYEMWEKAEAEYAEKVDDLVHEEKKERESWQDRKQDIENEIEELLQKVNALKKSREECVNTIRHLDDTIDKAIAVHEPEKEALNSELELVVKRKADIDTRAAEIDEQERKIQQLQERHDKDIRRQESELAMLNQSISEARERANVGHEDADEIDRIMRTLISDFEVQLEPKLDELVSRQHDTDEQRARVDSLSARLITTKSKMQRLSKDIMIVESQLPELEEQKTTAVGGRDFKTAAKTSSKIKSLKSALEQSIIQRKTLQDTVTNAEAELKEARQQLSDMIQERKEAERTIGEDILQSIQQCRQNLIIARERLAENQYRVHSLLRSEITSLENRIKYITMKFEISPDLIGELQRHSSKSSLRSVGRSFSKEGEQSTATLDELESLLKKAVAEENYEEADLLQQQIEELDKFKYDQLSHTSPSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSL8</accession>
    <name>A0A8H7PSL8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_001978</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="7"/>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSL8"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF26">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034765998" description="Beta-hexosaminidase" evidence="9">
        <location>
            <begin position="26"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="11">
        <location>
            <begin position="29"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="10">
        <location>
            <begin position="168"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2179128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="568" mass="63344" checksum="E1B8DF16DEFCF42F" modified="2022-01-19" version="1">MSAALLMKFITVLAAASLLVASIDAKTWLLPIPQSLKWTGSEIPLDENFDIHAPDNAQAQEAANRYKKLILKEKWVPYQKNVTEITPLKKGGVLKSLQIGIKDLNVTLDFGVDESYNLTIPETGGDATLDANTWIGALRGLETFSQLFVKTDGQLVAHSSVIQDWPTYPHRGIMLDTARNFYEVESILRTIDALAYNKMNVLHWHLTDSQSWPLGLNKHPELAEKGAYSAEQIYSVKDLKKVVSYGQSRGVRVIPEIDMPAHTASIAKSHSDLVTCTDTNWLTNAAEPAPGALDPTNNHTYSLIEDIVEELSEIFPDSFYHAGGDEVSSHCWKQDKKISKYLKKHNMTTNELWSQFEDKVGTIVNNNKKRIMIWEDAIVKAKADLSKDVAVQIWTTIPEKIIRRGHDIIHSSSDYFYLDCGGGGWVQNDTSYVTSNQSATAGVSQNYGGAGGSWCAPYKTWQRIYSFDMTYNITSNPGDGQVLGGEAALWSEQTDDTDLDAKLWPRGSAAAEIFWSGSYDKEGNRRSLDDMWPRINDWRYRLVRRGIAAIALVPQWCLSAGTGCLITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PT38</accession>
    <name>A0A8H7PT38_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_001602</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PT38"/>
    <dbReference type="OrthoDB" id="205099at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="11">
        <location>
            <begin position="68"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2178756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="485" mass="54745" checksum="25788FF54BE9FC40" modified="2022-01-19" version="1">MHQAKQHREDYDSDLGISSVKSKKKGAESEVFNTASTSTSSSSVSTPNNANDQSNLNQLTLPNEMAGMVPLKLVIGKLVHQCYADLHELADTLPSMSEVEKKRLILYYATNARKQFVKVLVLLKWASNAQNIQTCQNIMAFLSNQNKVFQDTVDYLHKIHTELPAARVRNYDIPTAVDIMTSGTYLRMPSKMKDLIPPKALMDEEVLQTWTELNDIIRLRMLTSEVLPSPMRNYRIADGRIYFHVENEFEVSLTLMGPSHDRRWWIVSLDILANSTTEGGFNDIDISLSEPQAQRLKAVAQHHLTSAPPVATGNQIPKPTTLPDGTTTEEIDNAAPTKNLQFPLVRLYDYLHMFCLNLQLEVLYLQSTSLQQWTQRGNERGNYIEISIVDDEEANETSQNNLSSTTVQDELRLLSLSAGVGASLDLNNLTDDEALKVVKALKYPKAHLAVHWQRSGKLFSNYSELHDYQIVSFAIIFCRLDLHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTL9</accession>
    <name>A0A8H7PTL9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTL9"/>
    <dbReference type="OrthoDB" id="29523at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF27">
        <property type="entry name" value="PIN2_TERF1-INTERACTING TELOMERASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2180117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="395" mass="43499" checksum="3E208CCCC812FB38" modified="2022-01-19" version="1">MGLAGPRTKQRIGADPNNLHWSNDTGKFGHKMLTKMGWAPGKGLGTNEDGHTEHVKVRLKDNNFGIGANKKNMDNWLDNTDAFSRLLADLNSRVESEQSSATSTASKADDSEDSDASAKKSKKKSKKEKKDKKEKKSKKEKEKKEKKSKKESSDEEDDSAVIVTSTVTHRNAARAKFLRAKRLASGKDVESMSEILGIKSNSASASSSPIVTEEKVEVTTIENPTGVPMSVNKMNVQDYFALKMQKIKASGIASSGFKTNASSEEDKEEEEEETRPSFGGLGFTGSTESSSSLGFGLESRTNGLVTGNGLGFVKSTTSEMTMQVKTDDAPKAKKEKKEKSKKRKHEDVESDESEKKDKKSKEKRLKSEKSASKDKKVDKKEKKAKKEKKEKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUM8</accession>
    <name>A0A8H7PUM8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glycosyltransferases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003577</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUM8"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034509088" description="UDP-glycosyltransferases domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2179794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="62324" checksum="68651D7DA2D2769C" modified="2022-01-19" version="1">MKIFHLILCLWWFEIAISLADHIQRELSYWVQKNIVISILTPGSSHVTWVLEIGQELAAKGHNVTFLARADHLKYAKDYSGINVQSISEPIRTMNEDSWGTLLKKKDTRIESMKMLLDMVNHNFPKDYEKHVEYIQNQAPDLFICDHLTDSCIRAAEMHNIPFILTSTVLTAPDVPAYYINSYIVGEPTTENETMCTRIYNNYIYPAKVIWHLRKIIKESAQIRRKLGISSANQLIPKKINDVVKLVNNFYGFEPARPTTPLVRFIGPVMQKTFQDLEADHQQFLGNHRKIAYVAFGHHAIASHAEFEQVLTALIESVERRTIDGFVWAIVKRSLLPVSVTTHRGSHVNVTDIMENPEKYPHYLFPKWAPQFAILSHPSTAIFITHGGANSIFEGYFTGKKMLAHPYFADQPSNAKLLVSTGAGLDYDRRNLNASEIVHKIERIVTDENGKFAMNAKRMSALVQIKARDAARNGASAVEEVLFTAIDDKVPHMYLPSRNMSYLKAMNLDIKIMLLSSIALLVTATHKFKKWFEISNQAQILKYKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUR5</accession>
    <name>A0A8H7PUR5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_004027</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUR5"/>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07500">
        <property type="entry name" value="HAD_PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14447">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13740">
        <property type="entry name" value="ACT_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01137">
        <property type="entry name" value="C1.6.1:_Phosphoserine_Phosphat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01136">
        <property type="entry name" value="C1.6:_Phosphoserine_Phosphatas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00029">
        <property type="entry name" value="phosphoserine_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="SPX" evidence="13">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="185"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2180238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="648" mass="72199" checksum="91FA5AD960B3588A" modified="2022-01-19" version="1">MKFGKYLEERKAHIPKDHADHCIDYVGLKLLLKQEVYQNSIKLELSSRSWSSQEEGRSFSDLVSERLKSLQVYEVSFIDKLDAQVERCSTYFDAESTKLKHAYDKIQQADADATAQLYQQVLALEKFVFLNYTGIVKILKKNDRHSGLSISEPYLHRVGSLPLVRAETLSALKQSLMYELSRRQVNPSETVTPASPVMMRSRSSNTSRSATADLPSSPLQPNQKVLISLSGPHGTDIIGAVLDSVAKHDCVVEDFMLSRLYHNVTFGVLITLTTDNVSIFRDLANQARKWNASLTFDVPDTQATEPAIKHMGEKEIKNNHKEVFLPPSLEQAPYSGRIKYAATLLNQTGLSSEFLFKWTQLLLENHISVEKMRRLNVGDGKVSCAEYQISVPESLEMDSMKKQLIELSRSFGTDVALQNDNVFRKNKRLVVFDMDSTLIQQEVIDEIARHAGVMDKVSAITEAAMNGEIDFKESLRRRVALLQGTSVEVLNTVRDNLTFTEGAKYLCKALKRLGFKLAVISGGFLPLANYVKAELGLDYAFANQLKVSSDGLFLTGETVGATVDGMRKAELLEVIAQAEGVSLDQVIAVGDGANDLWMLGKAGLGIAFNAKPLVQEQAQTRINQKSLKYVLSLLGYSDEDMQQLSSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVH5</accession>
    <name>A0A8H7PVH5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVH5"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052981">
        <property type="entry name" value="Ingression_C2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052">
        <property type="entry name" value="CONSERVED SERINE PROLINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_2G01790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052:SF3">
        <property type="entry name" value="INGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="16"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2181349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="432" mass="47045" checksum="58894704357B6CA6" modified="2022-01-19" version="1">MALPGYLKVIETYSLRKGVLIGSSSSAEIFFVVTAFQTLHVLSSNILCMSKGIGELVVVALKAIIGKQDPLCRFILGKHSQITKADIRGGQHPVWDDQVNLPVDDGINKLRFRLYDGAISKDIIISDGELDITKVMKEGELDGWFPLQYKGRSAGDIYLELTFYSSAKPRVTKKLPQEPPEPQQRRNKPLPRPPPEPPLMYRHSIHIPPSQQNSSIRPPPISTGGPGYGGPASAGYPPSVPAYPPQQQDRPPPGHQQYQTSPAMYPPVASSNLPPAGFIDPSTRPPPMGNPQGYGGFPTPVVTPRIPQQSAPYSAYPPVPQSPMYQSTMLQQAYDPQQQQQQQQQQQQQSYQQGYDSPGGYPARPVRQNTLSMNNQSHAYPPSSAGYPPASGYPPESGYPPASGYPQASGYPPTSGYPPSAGYPPSNGYPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWK8</accession>
    <name>A0A8H7PWK8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_009004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWK8"/>
    <dbReference type="OrthoDB" id="2373093at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2181421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="442" mass="50486" checksum="12FFE4D323B6A91B" modified="2022-01-19" version="1">MATHAPAWMPFANRQHSSYTLGGLTIPFISTPPSALHYSFLGFRGSSAPPVLSHPPDKSPTNTFAGYFRSNKVRPSSSYAESGPYNQRSRQVHAQNELVNVLPIAAVDNRYQTVSRDFTKWQDLTDVSAGQVFVYSTIQSLPQGSLEDYPVFKQDTKGKDFDEKSFVSWQESRLTDSYTQDGHLLYGPSDFEPARPRSFPYFLPMPLKRVLNRHTWTDCEDRESSDDAFRPSISSNNTFRVSQNLQAHYNDQMFKTPERQWTGFLNKPSPAPSSEIMDNMHRNVPTVSSLSLSEISLDKPRPMHHIMSSPYQMADINAVERGFSYRPSPPQDRFWNDQTLLFLFGFLFFPLWWIGAFKAIPSQKPKVYNAYLGNTTVLFEQDILQRPPPRSPSPIVHLRSPKPDLATSTKRRFQQMNRIMTVISMILLLFAAGMLIWYGIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWW7</accession>
    <name>A0A8H7PWW7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_007056</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWW7"/>
    <dbReference type="OrthoDB" id="2436689at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034172888" description="CFEM domain-containing protein" evidence="5">
        <location>
            <begin position="17"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="6">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2182129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="159" mass="16118" checksum="1EFD94E5AEDFC4D8" modified="2022-01-19" version="1">MLKSLCLLLLACVVTAFNSSALPPLDQVGTCIATCVLNTGHSVCGSQFTLDDTSVQCACTNPTFNSTVHQCVSANHCPASNIAVVEKAYEQLCQNQTVSTASLSSALPSSTNSASATLQSSISPAAASADAAAGSSKEFPFSGSAVAVFVVLTVGTIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXP5</accession>
    <name>A0A8H7PXP5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_008952</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXP5"/>
    <dbReference type="OrthoDB" id="1926212at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046813">
        <property type="term" value="P:receptor-mediated virion attachment to host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050498">
        <property type="entry name" value="Ycf3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE SPINDLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2181369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="217" mass="23931" checksum="8BE3530794BB415B" modified="2022-01-19" version="1">MGYQGDFKNLLKMYRLTKVTTRAATLRVLKPVTGSPRVSLPVWQHGTRYATRALSTSRPLMDRAKDAQSHLDLGTEYLNKGSIDMAMNSYHQSVQIAPSSAGYFNIGICYFQMGKHKDAIQAFEKSLGLQPHNADAHTNIANCYLMLKDIKSGVKHLEQATNFNPLDGEAQYNLGCVYDAMGETDKALLRLQMASDAGIAMATKKLKQVKAKAAKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PY80</accession>
    <name>A0A8H7PY80_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_006845</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PY80"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000024">
        <property type="entry name" value="Probable serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000192">
        <property type="entry name" value="Serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="114"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="432"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2181920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="505" mass="58316" checksum="CB73708DFDA12C5B" modified="2022-01-19" version="1">MDVVAPLSDISPSCEDVDMENEVFFDRDATPLPASALDRAAMAKLRLENYYKDSIGRAIERRQRYVPHAFIQMQSMVRTTTNVEERKQRQLHALGRKESDFLKLRRTRLTLSDFITIKVIGKGAFGEVRLVQKADSGKIYAMKTLRKADMMQKDQLAHVKAERDVLAESNSPWIVQLYYSFQDSQYLYLIMEFLPGGDLMTMLIQYDTFSEDVTRFYMAECILAIEFVHKMGFVHSISFADKTLVPVTRDIKPDNLLIDKDGHIKLSDFGLSTGFHRTHDSQYYQRLMTANRDKETAHPSIAKSSSITLTLSSKDKIETWKRNRRALAYSTVGTPDYIAPEIFQQQGYGQECDWWSLGVIMFECLCGYPPFCSENHHETYRKIMSWRDSLIFPDDIVLSWEAEDLIKRLICSPEHRLGRNGADEIRAHPYFAGFDWTNVRDRVAAHVPKLKSITDTSYFPTEDLEQVPDMPDMEDVKYEHSTGADLAFVGYTYKRFEYLTNTNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYP2</accession>
    <name>A0A8H7PYP2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_007160</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYP2"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17966">
        <property type="entry name" value="DEADc_DDX5_DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="161"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="364"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2182233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="443" mass="48271" checksum="5A12040CA49BFD82" modified="2022-01-19" version="1" fragment="single">YEPSSHYGRDRGGDRDRGSDRHGGGGGSYGSNSYSHGGSYGGGAGGQGGYGGGGYGGGYGGSHGGGGDKMSNLGNTLTAPKWDMNTLPKFEKNFYVEHPNVAARTEQETLDIRTKFDMKLFGENVPKPVTAFDEAGFPNYVLKEVLELGFQAPTAIQAQGWPMALSGRDVVGVAETGSGKTLAYCLPAIVHINAQPFLEPGDGPIVLILAPTRELAVQIQQECTKFGKTSRIKNTCIYGGVSRGPQIRDLSRGVEICIATPGRLIDMLESGKTNLRRVTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVQRLAQDYLNSYIQVTVGSLNLSASHNVSQIIEICTEPEKRGKLIKHLERILDQPQNKTLIFTGTKRTADDITRFLRQDGFPALAIHGDKAQSERDWVLSEFRSSRSPIMVATDVASRGLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYP5</accession>
    <name>A0A8H7PYP5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_006129</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYP5"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17982">
        <property type="entry name" value="DEXHc_DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003770">
        <property type="entry name" value="ATP-dependent RNA helicase DHR1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="383"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="658"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="176"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="234"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="634"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="635"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="672"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2183134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1208" mass="135017" checksum="652C150E2709FA6C" modified="2022-01-19" version="1">MGRARPRYNEKARSSSRKPTQKAHPRARNGGLGASAYESNDSAKPESRKAAEPEDTNALIYVQKQKEEAKDQEVQAPKMSSKKKKRLEKYIEQKLKKDARVGLLEKLSNSAWSSDLLVSSRKLGQNKETMREKLRRALNEEKAGLRKTDSDVPLFVEAQVGDSADFVVPEKTEVNIVSKKKSKKKSKSAADKKEDSPEILNATESTGAEEPIASTNIVNTNVEQKPIVVGGALKHSVSGQAAPLVMKKRKKKKSTIPEAVRKKHKTARGNESESSFDSSDSEYDNMTDEEPTARPKSQAEEDIDNGPTALEEALEAVKNVKEPVALRVVEEDDDVKKLLLERNRGGDLSHDDYKPFYVTVNRKPEVQEGRMKLPVCGEEQVIMEAIRNNTVVIICGETGSGKTTQVPQFLYEAGFSHPESVNPGLIGVTQPRRVAAVSMANRVAHELNVKDEVSHQIRYDTTTSKKTRIKFMTDGVLLRELAADFLLTKYSVLIIDEAHERNLNTDILIGVISRVLRLRANLSKQDREKIKPLRVVIMSATLRVTDFTQNKALFDTPPPVIKVDARQYPVSIHFNKRTPELDYVDEAYKKIGKIHKRLPPGGILVFLTGQQEIVNLCKKLRKRFPMLAQTASSKEIAKEKANLETESKTSTVSARNEDVETEEIELGNTQEQVEDFELPDSDEEDDSDDELGFYGDEEEEQNDEDEADPPLHVLPLYSLLPTEAQMRVFQDPPEGTRLCIVATNVAETSVTIPGIRYVVDAGKVKERTYNLNTGIQSFDVDWTSKASADQRAGRAGRTGPGHCYRLYSSAVFDGYFPQFSVPEINRMPIEGVILSMKSMYIDNVVNFPFPTPPPKPNLIKAEKILSHLGAIDRDQKRITDLGRTMATFPIVPKFAKMLIIGQQHGCLPYVIGIVSALSVGDPVLRDIDLNEIAENESDDDDGGGDIRKMELQNLHSESVAEKERRKMTRSKYYQVQMKHAGLDPTSDIIKLLNVVGAYEYAGASESFCEANFLRPKAMDEIRKLRRQLTNIVVANCDGVDVSIDPKMPPPSALQLTVLRQIITAGFIDSIAVRKDYIESGGSATGKFKSTRGVAYKVMWSDEDVYIHPSSVLYHQEPPVFIAYNEQFASSKVWLKGVTKVEPKWLSKIGKSLCTYGKPLDFPLAKFLDEKKTIKKCWVIPSFGPKGWPLPPVEVEQKLVGTRWVFSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZY9</accession>
    <name>A0A8H7PZY9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_006369</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZY9"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF50">
        <property type="entry name" value="BIFUNCTIONAL ALBAFLAVENONE MONOOXYGENASE_TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2183363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="63786" checksum="FDB767D9371D398A" modified="2022-01-19" version="1">MQSLLAAVSKDVDRLSAFYSEHILPYLARKSKATYIAAAIASFVTYQVYKMSHIPRNLRHIPAVPYWSYMRSVFSGTTQDARRDMIYSVLSKSPNGLYLKPSRGGWSVGVVGPQALRTVFLRKGIYTPINCIALSLHSNPNLIPQDDYPKSRALVTDKTFLVAKLIGGQNIISLNGSPWKKHRMIANPAFHRHMPVKLFGNLCEMMMDKFESESDGLSHVNVPALMQSNVGSRFTLDVIGQAGFGYDFESLENPDNEKVHIYNSIMEGLKNPLFFFFPFLERHFLWAFPNRRQQHENCDTLHQLFKSVIDNKRRVLVEQKEHNEDPEKDLLTLMLEAGEDDPSQALSVEELQENLTIFFIAGHDTTSNALSFALYLLAMNPDIQEKARREVLEVIGDGADMVHPTETQISQLKYIYMIMKETLRIHPPLQSSQLRVTEEDTELAGTVIPKGARLQADIFLAQHNPAVWKNPEEFRPERFAPGGENEENAKKGLAWAPFGNGARQCIGMNFSLAEQRVVLAMLLRKFTWSLPENSIHKDHLIFAPGMGLVNAKDLYLSFEKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0F0</accession>
    <name>A0A8H7Q0F0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0F0"/>
    <dbReference type="OrthoDB" id="3366990at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="53918" checksum="6A2F965CA06C9EDC" modified="2022-01-19" version="1">MSTTSSDLDVVDRELISINCSRLLHSNQQGFLYGTLEADLLAEVGDNRNEERDDLDDLEHNILKMPETEQESQQVVDELDELEQQILNANEEDRFSISSSEDEITMLEREILNASETQDASLVHRYRQFRAKNASKAISSSLEANNSRGTEASTIPISMDSSFFNSPATTGSALRRTIDSVTNESQRSDDMFENMEGDNPEYLAQLSQERKRPKRTLPPFSSQGITFNDRQYNTQISASSDVYGRQPSPTILHNSQVSNRMTDAQADAVRLTEQDFDGATSEATMERNVIASEHGRPMLSNIRQLPTVSLIVGPPDSADEYEWSDSGLTPPTSPEGNLFITIYHVGITCKQPTRSHFHFKGEPNDLNLAPVALSDTSNPPRFISVKQENNLITAPPAHRTAPVPTRSAPRKIRTLWTGPEIDALEDGLEREGWGRWAAIKAMHSELLKDRGSVALKDKARTEATRRHRENIPLGPYCGCPSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0J0</accession>
    <name>A0A8H7Q0J0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_006572</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0J0"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF189">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="92"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2183566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="628" mass="69484" checksum="C87CFE70A0E8ADCD" modified="2022-01-19" version="1">MALDNQSQEEQNHMNQTSYTRSLVADNHERDLGDSSSEKSAKYSDDHDSLQTLNEKQPTLSEKQNLDNLRSLDSPKYEMHEEIDIKDVKENSEEDNESGRALPLKQFIIVYTGVSTALPRIASEFESLYQISWVGTSYLLTSTAFQPLYGRLSDIFGRKPMLLFALISFLIGSALCGASTNMTMLIICRAFSGIGGGGIQSMCSIIISGKVSSKTARGWFSRNIVALRQRAKYHAITGIVFALATILGPLIGGFFVDHSTWRFAFYINVPIEIVTIIAIFFLLPLKSPKVSIVRKLKQIDYLGVILLVSCIVCLLQFPLDRGGSEMPWNSPIIITLFTVGGVLGLAFIFVEGKVAKFPVIPGHVFKIRTVVSVYISIFFTGFLYFGEIYYLPIYLQVVNGASATGSGLRMMPLLLTQVVLSWLSGLLTSKTGNYRYILMIGYLIMTVAAVLIATLDEHSSQFKQVGLLCMIGMATGCTMQNSLIAVQSAVEPKDAAVVISVRNFWRSVGGVMGVAVCGSLLNNSLYNRLPAALGSQFSDQLLSDIVSNPSVIHSLNPELQHAVINVYVQSLQIVFRSWIFYAGMAFLASLGIKQYELRNTIDKITVLEEEEENKYGKDVEKNEKKEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0L9</accession>
    <name>A0A8H7Q0L9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Adenosylmethionine decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_006345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0L9"/>
    <dbReference type="OrthoDB" id="1068353at2759"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.50">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018166">
        <property type="entry name" value="S-AdoMet_deCO2ase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01336">
        <property type="entry name" value="ADOMETDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0745">Spermidine biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="241"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2183340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="56620" checksum="E8A6850C3F6162F6" modified="2022-01-19" version="1">MFDSIVPPSVPPIQGDNYSAQAGCFEGPEKLLEIWFSPSPYHIARHQKLDGYNESDCELSDDSTPQSPTQSTSDSSDQEDPTRFSPEPVRRDHATAYDASGLRTIAKPVWDEMLAIVKCTVLNVIKNEHVDAYLLSESSMFVYPHKLILKTCGTTTLLMALPRILELAKIHCGFEKVWRVFYSRKSFMFPDRQCGPHRSWQQEVNYLDEHFDNGSAYKIGSHEKNHWYLYLTSPADDVRVHHDINDDDGEVHHQSGTHTPRNIHYESGTSTPFSSDSETDPSPFGNSGYPQQDETVEILMTDLNPEAMKFFYQMNDEPTGIEGGRRVDASTGIANIYPTAKVDSFLFEPCGYSANGLWEGAYFTIHVTPEPECSYASFETNIPCEISHKSPEPLKALIRQVLNVFQPGNFTVTLFSSQPQTAKKPLLEHRDGLRILEHDEKFEMLAKDKSDLHHLCRHRHHKMIHSLANMDGYKRTDRILYTFEGYDLVYGHYEQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0X2</accession>
    <name>A0A8H7Q0X2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_000273</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0X2"/>
    <dbReference type="OrthoDB" id="2019504at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010301">
        <property type="entry name" value="RRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026">
        <property type="entry name" value="NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05997">
        <property type="entry name" value="Nop52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="506"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="411"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2184364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="552" mass="62399" checksum="C1844D0C39C2D86B" modified="2022-01-19" version="1">MSTLMDSDNVVLPFGKQLAANEKKTRDKAVRSLQQFLSSKSELSESDLLKLWKGLFYCFWMSDKPLIQQALSETLGSLVMSLQQQNAIAFLGAFWQIHCDEWHGIDRIRLDKYYMLLRRVVHYTFKYIGEHDWDLGIIDDYSELLKNGPLKYVSIIGPTNNKIPNSIRYHLADIYLDELEKVVNAQLEKLDEEEDIEIPTTELLDPFINLLAKTPNKITANKVVDNVFSSILEKFATGMKAMLEIDDEDNEEDRPPFIYDVETLHPALAKAAQDPDTHSPNRKKLAALEKRFKDLIPGEEGENDEEEDDDEAPTLVATLDEEDEEDLEEDDDSARKTGWMNEFTAGDLIADELKEEPKPKERRRPDNGLLGGKMVSIDASTLDISGLETKVAPSEQPKPKKAKKSKKQAEEPVELVEAVEDMEDMEDVEDMEDMEPEEIEETEEIVTGVSDDGQSTTTKVTKKKKVQWVLDQNTIRRFQKARPIAAVATSVEPRVVRPMKSAIKITPASSEDGSEQEDVVVPNGHTGKKRKAAAAPSKKNGATKRKKAKDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1Y2</accession>
    <name>A0A8H7Q1Y2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1Y2"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2183810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="161" mass="17837" checksum="7E8589B8F915DE32" modified="2022-01-19" version="1">MARTAAILGYFGPRLEANTTFRYGAFVDLFGSLWCELAERQSCNCGAYIVAMAVSGARADAMMGRLCAPIDYFAEQFAVMAEIRDSIINDLFSTMSTNLPPWYRILPRDTEANGKSCHHVNVDPPKRTGWGFISDTLNIDPKDKYRVASYCNDSDIADIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q229</accession>
    <name>A0A8H7Q229_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q229"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="75" mass="8261" checksum="0EF8E9B9BA3F3AFD" modified="2022-01-19" version="1">MLCTNRGQSEPLPESKPIYFSIAYPIVDARKNAEAIEKDRPGENINVPLPRVSKNAPLKQPDVCNNATKEAGEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2Y8</accession>
    <name>A0A8H7Q2Y8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_006717</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2Y8"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="102"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="357"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2183706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="412" mass="46678" checksum="06346716040322A8" modified="2022-01-19" version="1">MPLKVLTSPLTLVTSFFSKKPKSPPSDSQTSPTSRNGRPSSTTSSVTFTNTVSIAGFSHGKSSSSMSSPCDSQFNESKEMLQYWHNRPLVFTDTPEYSLEDFELLDTVGTGTFGRVYLAKCGKNDQFYAIKVLKKAEIVRLKQVEHINSERHVLSRVNFPFIVDLYCTFQDTIHLYMLQEYVIGGELFSHLRKAGRFTNEMTRFYASEILLAIEYLHAKDMIYRDLKPENLLLDGNGHIKITDFGFAKKVDDRTWTLCGTPEYLAPEIITSKGHSKAVDWWALGILIFEMLAGYPPYFDDNPFGIYEKILAGKLKFPSHFDPTAKDLVKRLLTADRTKRLGNLKGGADDLKKHKWFRGVDWQGLLNKTVPAPIVPPHQHPGDTSNFEKYADAEPSDGQNGDIDPFRHLFPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q312</accession>
    <name>A0A8H7Q312_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_000524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q312"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2184615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="176" mass="19832" checksum="CE29BED3131EB1A9" modified="2022-01-19" version="1">MAPLFRIPGTDTWLVDATVDCRYIPSAPQQAATGSKPVLLVMYDRTLQQIAVREHACISLINDLPTFTSIWMKALVESLEVDLLEESNPLVLEALSFEREEASHVFPSVQDTSEKTCMVYSGCPLELHSLFCFGQPMEVWNSLQSFSHYRCPVAIGPVLYDLRNTGFGEPDFDRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q362</accession>
    <name>A0A8H7Q362_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q362"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17719">
        <property type="entry name" value="BRCT_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="112"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="256" mass="29386" checksum="65DF379DA52FFDE9" modified="2022-01-19" version="1">MQVRDFQVSCHWLAVFQKSRAQAKRQQRRKSLGRVASFVVMDKWLVKKPGLPNNKDQKQLEGEEKRNVFRFNDILYNSHLTGHQRRSTGGSGSATTWVHMREAKIKEQLPEKSSDIFKGVNIYINGTFIEWYTGDNKDLQLKQLVAQHGGSISYVLAQKKVTHIIVQSNLSGSKTHQYINLRKNLTKLVTSNWITDSIANGKRLSEWKYKVLKDQTQDDIYSHLHENPVKTQTVAVLLAISVVAELLAYYEPSKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q369</accession>
    <name>A0A8H7Q369_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_000986</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q369"/>
    <dbReference type="OrthoDB" id="9936937at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058841">
        <property type="entry name" value="HTH_76"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855:SF1">
        <property type="entry name" value="PEROXISOME MEMBRANE ANCHOR PROTEIN PEX14P N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25871">
        <property type="entry name" value="HTH_76"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEX14-like helix-turn-helix" evidence="3">
        <location>
            <begin position="51"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="PEX14-like helix-turn-helix" evidence="3">
        <location>
            <begin position="124"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="2">
        <location>
            <begin position="421"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2185073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="675" mass="76035" checksum="3DDAAF28FAE075DE" modified="2022-01-19" version="1">MVSSADCSSKIVSHKAYSLTYKVDDMEMEQSSIGAYQSEEFSLFTPEQLKQFHEFHSYDWDNDVEFQKGLQAIYSDGPANDEELLKAKQFYFSRKKHHINLDQYRQFEEYLERSMPEKSEEEEETVFDRFDKYSFSSDERFLNGLPSIVAGIAKSKPGATVDKTFYDREMLKAKAFYFSKFVEKLDLGEYLSWKETKKVAPACPYAHLWQNKGVRETTELDQDDDVFLKTEQPITSSGALTITFSSPQSDNLLTCERLKELQETVGLAKNNDTYTSVIIASNCKQEKTPDSGPDEPITNVDHKSLSSGLAFNETATECGKDLNVLQSSMDFLQARYYSLVKDIGNYIKDEEKPVFHLIDGKVPFSAACLYFLPNQLRIVTEHALLTLGINSLSHAPIPPLYVLNGIQKAANSKAARVPPRGSALYVALAPPELILLRGPELLRLGLADYFVPDAKYVDTLKEMRNNAPCPAPHTLEAVKVVLEMNKAYAGPDKIGVWEKEIEKVFDGCQNSQDLLDKLDEMEKPWSRTIAHHLRQQSPTLLEMVIQAVKLVTEHSISLEECLDLEDRLNAIWRTTSDYKTFASRDTSTDMGDLSWSPLDSTVIDNLESLKKPAFSQEDISQFHWSPEPSAANAENTDSDAASSEVDEDEIFVCPVTGLRGKMPEGHSPVAIQQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q454</accession>
    <name>A0A8H7Q454_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q454"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31964">
        <property type="entry name" value="ADENINE NUCLEOTIDE ALPHA HYDROLASES-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31964:SF113">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="22"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2186164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="176" mass="19662" checksum="E95D3B6B50E45A7E" modified="2022-01-19" version="1">METHDIVHQDPKSDEYNTLTRVVLLCLDEDTGENVFHWSVQNFINAQTDMVVLVHVRPSEHFTTPYGNQTDYLIKLAERHRDESHVLLKKFGAILTAKKIACKAISMHGDPQSEIVKKSQEVKADIVIVGSHGSGLIKRTLLGSVSQYCVNHCRCSVIVAKPSRPERSPTGSDSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4N2</accession>
    <name>A0A8H7Q4N2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_002872</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4N2"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039663">
        <property type="entry name" value="AIP/AIPL1/TTC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242:SF18">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2186434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="198" mass="22555" checksum="1081CF430E65B97A" modified="2022-01-19" version="1">MRSLVWPVCRGAPAAYCAYNKQLMDLQAKLDKGTELKNTGNKAFTSNDVKGALTNYHQAIFYLKGTENIQQAMGGVSNEQEDPVKSQMKQVLGTCYSNMAACLLKEEKWPRVIDYCKKALEADPKNKKAHFRIAQAYIRTGKLDLAREELQDLLRSDPDDAGVKRELTLLKEKDKIETSKEKKIYKNMFERMAKQPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4Q2</accession>
    <name>A0A8H7Q4Q2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4Q2"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016034">
        <property type="term" value="F:maleylacetoacetate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03194">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF4">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="14"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2185838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="248" mass="27941" checksum="4DA4D786C5810F11" modified="2022-01-19" version="1">MSSTSTLYLLNQTYSSWSLRAWLAARFVNYPCNVHVFRLSKDIDYGTPKAVEMLSQAGPTKKVPTLHVEVDGEKIIIFETLAIIEFLYEANPQIWPSGKANRALARAISAEMSASFMSLRSNYPMNVKARLPFSQAYFDQIPGNATDLARVVKIFSTCRARVNEREELKKIDQGFLFGAFTGADAMYAPVCWRIKSYGLPVEDEAAKQYVETLLNSDLVQQWVQEAALETEVIPVSEIEPLIKQAEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4R4</accession>
    <name>A0A8H7Q4R4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002525</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4R4"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034324380" description="Endoplasmic reticulum transmembrane protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="7">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2186087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="217" mass="24245" checksum="3DFBB346EDC8398C" modified="2022-01-19" version="1">MTLHYTLVFGLMVFELTQMLHTEIHSHINVASIIQLPLPNHWRKSLLTFISRSPLISKLQYGLKIAFVFVFVLFIGTFSLGQIVADSVNRLQSTLPIENQAEQVPGAAAQPNNLHMDSTFAARKFYAQRNIYLTGSTLLLSLILSRTYSLILELLTAQEKLAAAQSGQSNDGEVTQLRAELKELQGKDSDIDGVKEKAKLEADEYDSLARQRKAQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5D2</accession>
    <name>A0A8H7Q5D2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002554</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Cd(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5D2"/>
    <dbReference type="OrthoDB" id="2338at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0104">Cadmium</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2186116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="455" mass="50734" checksum="CCDD647B75F06A23" modified="2022-01-19" version="1">MSNSNWSAESWKEKPVLQDVVYENKEHLNKVLKKLECLPPMVTPTEIEDLRTQLKEAALGKRFLLQGGDCAELFDYCSQSPIESKLKVLLQMSLVLIWGARTPVVRIARMAGQYAKPRSKPTEMHEGKEIPSYRGDNVNGFDPEDRQPDPDRLLSAYFHSAATLNYVRAILDSGFADLHKPQAWNLDHVRSGDTRKEYQAIVDRLTEAMDFMHTIGADSVPSLSHVNLFTSHEGLLLDYESSLTRQIASPATGEKKWYNTGAHFLWIGDRTRQPDGGHVEYMKGIENPVGVKVGPSTNPDDLPIILDAINPSKEVGKVTLITRYGAGNVEKLLPAHIEAVRKSGHTPVWVCDPMHGNTKSAIGGIKTRHFADIMEELTSCFKVHQSVGSKLNGVHFELTGDSVTECVGGSMDLKPSDLSSNYQTHCDPRLNYEQSLDVAFLIAQYYEEQRTSAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5G0</accession>
    <name>A0A8H7Q5G0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002666</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5G0"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="88"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2186228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="670" mass="74298" checksum="FFD8DC8DABC03145" modified="2022-01-19" version="1">MPRTHSQPVLTPPQGESHVRRSTLATDEIINRPSPDINTLYDVLQSSAKRFGDKEALGFRNIVDIIEEEKEVVKVVNGQEQREMKKWKYFQLSEFQYVGYNKMSEICHDIGAGMAHLGLKKGNKLEIFAATSADWLFMAHSAFTQSIAIVTAYDTLGESGLLHSMNETEVEAIFTNGDLLSTLLKILPSCPSLKHVIYNGEAKPEVLEKLRAQIGSVLSLKELKALGRQHPTPPVKPKKEDICCIMYTSGSTGNPKGVILKHSNLVAAIGGVNKLLGKWIGKEDSIMAYLPLAHVLEFLVENLCLYWGVTLGYGTVRTLTDASVRNCKGDIKEFRPTILTGVPTVWESIRKGILSNINNASPTVKKVFERAFTTKAWLMQRGMPSPVLDKLVFSKIKEQVGGRLRFGLSGGAPVSLETQKFLSVCLAPILGGYGMTESVGMCCIMTPENFRYGRVGAPVPCCEIKLVDVPDTDYKSTNKPKPQGEVWVRGPSITAGYWKRDDVTAETIMPDGWLRTGDVGELNSDGTLTIIDRAKNLVKLSNGEYIALEKLESIYKSCVVVNNLCVYGDSLRPKPVAVILPLEPRIREIAKEFKLEGEFEELCASEVVRKEVLRMLLEQAKVGGLKGSELLHDIHLSHAEWTPENGFLTAAQKLKRNDINKQYKTQFDAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5S8</accession>
    <name>A0A8H7Q5S8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_002846</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-18S rRNA processing. May bind microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5S8"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000003">
        <property type="entry name" value="Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000001">
        <property type="entry name" value="Probable Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="9">
        <location>
            <begin position="285"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="403"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="505"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2186408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="518" mass="57908" checksum="05748B95047D130E" modified="2022-01-19" version="1">MLVLYETAAGFALFKLVDDGKMEKPENIWKDFQTADQANKTVKLKAFQKFENTTDALAAVTGIVEGKLPKNLKKFLETEISDKEMKKESLIICDPKLGSAVNKKLGINVVSDSTVMDLYRGIREQLESLITGLSHSDINAMSLGLSHSLSRYKLKFSPDKVDTMIVQAIALLDDLDKELNIYAMRVKEWYGWHFPEMGRIIVDNLAYAKTVKLMGFRTNAQDMDLSAVLPEELEKELKDAAEISMGTEISQEDIENIHALCDQVISITEYRTQLYEYLKNRMNAIAPNLTMLVGELVGARLIAHAGSLMNLAKQPASTIQILGAEKALFRALKTKHDTPKYGLIYHASLIGQAGPKLKGKIARMVATKASISVRVDALGDGETPDIGLAGRTKVESRLRQLEGRAGAQINKDKSGGKKQEAFQFNKSTAYSSKSDTVMTEASSEKKEKKEKKEKKRKADEEEEDEEEVAAVKKEKKRKTEDGEDKKEKKKSKKDKKADDEDSSKKDKKKKKEKKSKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q641</accession>
    <name>A0A8H7Q641_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_002169</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q641"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23649">
        <property type="entry name" value="Khc_CBD_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000031">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059182">
        <property type="entry name" value="Khc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="5"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="898"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="587"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="87"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2185734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="931" mass="104155" checksum="9B42A86C991420B9" modified="2022-01-19" version="1">MSGNNIKVVCRFRPQNSLENREGGVPIINIDGTGENVALKGNDYQGGFAFDKIFGMDTKQKDVFDYSIRSIVDDVVAGYNGTVFAYGQTGSGKTFTMMGADIDDENTKGIIPRIIEQIFQSIMTSPANMEFTVKVSYMEIYMEKVRDLLNPSQDNLPIHEDKSKGVYVKGLLEVYVSSTEEVYEVMRRGSENRVVASTNMNAESSRSHSIVMIAITQKNLDTGAAKSGKLYLVDLAGSEKVGKTGASGQTLEEAKKINKSLTALGMVINSLTDGKSSHIPYRDSKLTRILQESLGGNSRTTLIINCSPSSYNEAETLSTLRFGMRAKTIKNKAKVNADLSPAELKAVLKRVKSEAVTFQTYIAALEGEVGIWRTGGTVPEDKWASIDKIKSGDFTALPPASGFKSPIPEDTSRPPTPATVLEKDEREEFLKRENELMDQIAEKETELATREKLLESMKEELGLFKDQEQTMIKENQQMTSELSELKLQLQKISYESKENAITTDSLKETNQELAAELEELKKNLAEMRASHKPSSDSEKEKKKAEKMANIFSGIDASGEITEKERHIRNALHRLDGDNGSTLSIEELAAVRRELAESKSLLEQHSKTISDLSNEKATLESKKVDLEIRLNTLEVEYEELLDKSIAEEENADDKGVDIAETVSNLKTKLESQYAAKKELQEKEVEQLKQEVERKHTDFEKLSAAMTDLKTANDELQNALSAQPRQGGPDLSEKEKDMERMRKSMAQQLADFEVMKKALMRDLQNRCEKVVELEISLDETREQYNNVLRASNNKAQQKKMAFLERNLEQLTNVQKQLVEQNSSLKKEVAIAERKLIARNERIQSLESLLQDAQEKLISQNQKFEAQLQAVRERLEQARSSKSQNSMAALNFGRIAKPLRGGATVAAENGSPTSPTDDKRDRRTSWIPGFINSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6D7</accession>
    <name>A0A8H7Q6D7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coth protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_002352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6D7"/>
    <dbReference type="OrthoDB" id="10267127at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050">
        <property type="entry name" value="INNER SPORE COAT PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050:SF1">
        <property type="entry name" value="INNER SPORE COAT PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2185914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="58042" checksum="3941F1A9190C66A8" modified="2022-01-19" version="1">MRCCDSTREESAGHIQKNKYPPRFAISTASVHCQLATYTALSPSSTVQVVVKSKTYTLKSSTATPLVHVGTAPGGASYRYVIKGKKEKNTRSAIPAGGSSKPEFFDRPNSVSVPKLPKLYENKYPNKVYTAAHLENEIASVHFSASASEIKKFSQGIKKFVNTTLAIGGESSRDWAKRSYKVSISKDSDGLYGLRKFKLRAEASEPTMIREKLYYDMLDAVGLPTPSTSYVRLFINNDQIGLFLLVDEISNPWLKSEFNGGAKYANGILYKMDGGGDKVGANLAYLGTSESKYSDFYSVEEASDSGEKDLKRLINFTKWLKDNGKKASTADWDKQIDVDGFLKHMSLEFLNAAWDNYWVSASNYYIYHDPKKNQLQWLTYDLDYTIGNGIESPQKHLLTDTYSKYSSDQPPRVLIDTVLASTTYKKNFEKILKNVNEKLYKPDILNKRIDGLVSLITDDVAWDRSLKRVAKGDDWEWDLSDFKHSLTAGFGEDGQYYGLKEWITKKYNAVHKQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6K5</accession>
    <name>A0A8H7Q6K5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytoplasmic tRNA 2-thiolation protein 1</fullName>
            <ecNumber evidence="6">2.7.7.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytoplasmic tRNA adenylyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NCS6</name>
        <name evidence="6" type="synonym">CTU1</name>
        <name evidence="10" type="ORF">INT43_002646</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="6"/>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6K5"/>
    <dbReference type="OrthoDB" id="198857at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000054">
        <property type="entry name" value="Cytoplasmic tRNA 2-thiolation protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03053">
        <property type="entry name" value="CTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032442">
        <property type="entry name" value="CTU1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020554">
        <property type="entry name" value="UPF0021_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00269">
        <property type="entry name" value="TIGR00269 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16503">
        <property type="entry name" value="zn-ribbon_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01263">
        <property type="entry name" value="UPF0021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="8">
        <location>
            <begin position="53"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic tRNA 2-thiolation protein 1 C-terminal" evidence="9">
        <location>
            <begin position="280"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="56"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004976-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2186208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="360" mass="40927" checksum="3126AC4711756C44" modified="2022-01-19" version="1">MVKYCAICEKDKAVLRRPKTGQQICKSCFYFVFETEIHHTIVDNKLFKRGDRIAIGASGGKDSTVLAHVLKTLNERYDYGLELYLLSVDEGITGYRDDSLETVKRNQQQYELPLKIVSYSDLYGWTMDEIVKEVGLKNNCTFCGVFRRQALDRGCVMLGIDHVVTGHNADDIAETVLMNILRGDIARLGRCTEIVTKGDTMVRRSKPFKYTYEKEIVMYAYFKKLDYFSTECIYSPNAYRGYARTFLKDLEAIRPSAIIDIIHSGEAFEIKSGVKMPTQQTCTRCGYISSNELCKACVLLEGLNRGLPRLGITREQRTRNDEAKETKKGVTKIQHFSEIQRAEATAPSAARALKKVDLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q796</accession>
    <name>A0A8H7Q796_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor IIIC subunit 5 HTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002484</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q796"/>
    <dbReference type="OrthoDB" id="5598268at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001002">
        <property type="term" value="F:RNA polymerase III type 1 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001003">
        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.160">
        <property type="entry name" value="TFIIIC, subcomplex tauA, subunit Sfc1, barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041499">
        <property type="entry name" value="Tfc1/Sfc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042536">
        <property type="entry name" value="TFIIIC_tauA_Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17682">
        <property type="entry name" value="Tau95_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Transcription factor IIIC subunit Tfc1/Sfc1 triple barrel" evidence="7">
        <location>
            <begin position="58"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="6">
        <location>
            <begin position="204"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="358"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="571"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2186046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="68596" checksum="64231C9D53BD7C45" modified="2022-01-19" version="1" fragment="single">NQWYYNIRFSKVEAYESGALISVSSKISQLQYAPITLTTTMSTSKAEKLKLPDKEFLNIEYPGRVNNVDKALNNIGGIASLTRNHKQNGKEIELKFRPNDPFSHGIVGNVVSTKNLVLKVTRQVKKSNPEEQVGDVKAEILGQIRKTCRFRVLILRAPGLADFQFLVPPENRIAKVKKAVVECDVDQMMQFNAAEDDYKNLELVPPPLFTRLEFPFDYSYQQNPAVAKVKVRQPDGTVAIRLVNRYKQRKAAHYFLQYEAEDVPDGPPSNFRPIVGEALSVLPIVTEVYANWNPSSVVRGAPSLDEICLERVLPAISYNMISGPWRDTWIRYGYNPKKHKNSYLYQLLDQRMLPKAKQTTLQVPRGKRRPLEPAEHKHMEEPSHENDVPKMNHRWDGQSKPEAQNNYMLCDILLPDIQDAIHLDKYRRDFCAKECGWCYPSIYKDLRKVMKAVFLAVTNDEPIPTLEKIGVNFDASVESDIAAERQAKEAEKEHMDTDDSAIDTATSAGPDVSARVDELMRTLANAQGKWDHIFYATLCCDRALNLLCHLGMEFEDELNLEELEEYDVMFGNEDEENEDIDNMGDIEDEEDQIDELDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U752</accession>
    <name>A0A8H7U752_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U752"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="7"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2173151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="208" mass="22103" checksum="2194510274572628" modified="2022-01-19" version="1">MAPSALIYIVYYSMYGHIYTLAKEVQKGLEAQGVEVKLFQVAETLPEEVLTKMHAPAKQDVPVITAEDLKAADGILWGIPTRFGTMPAQLKAFLDSTGQLWQTGALAGKFTGTFFSTASQHGGQETTAFTAVTYFAHHGMIYVPIGFPDPACFDNSVVIGGSAYGAGTVAGGDGSRQPSEAELRIATIQGEKFAKVVKAYKAGQATSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7W6</accession>
    <name>A0A8H7U7W6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_004852</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00243">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAR" evidence="5">
        <location>
            <begin position="1375"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1319"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1504"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1324"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1514"/>
            <end position="1524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2172310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1524" mass="173659" checksum="54551B025176120A" modified="2022-01-19" version="1">MGMSKVELPVQRTDSFADRTSSPRFSHHIHADPKGDTDIEGRKLNTLDASFCSLGSFKPNTEDGKGIDENCSISSYETQDDLCNLITNFSRIYPSTTGTDGEKDSKAVQALESLLLKLAAPISLQTEATGHHFSPANIPHNSVSSTAQFSDSTHGLGPDEEITNLDVGKSPGKIVDYDCLLPPEHADECGEEVLDDIRWMENVLMDIVNHLEYVISLSVPLTTWNHSGTISAICRARCARFLRQFNGHRLNEEAEPIATDTHNSDLQSVSSLLASLALANDTINKEALKQWEVVKDKCIGSRLCQAAVLSFELKYAFTLSETYDLNFRLIILSLRQRISICDQIVRKLRCEEGLMWDDAALLSPNLQMHEKGEDFDDFNDLATVSRIKAMVQYVRELHSVTPESTLSVGGLVERTNELQQRIGRWGQQFDNLWLELNQIWTGKASSEVDDRRRDSFNSLKDQLSSIKAELDDSIIQHSRVKTDAANLYVLRHYDESKLQIIDMEARIEEMEHCIEVLDKYDGWCKLCATIQGNIPTMDETIMAILEKRHKWAANLKNVSIHATSDDLREQKNSLDKSIMNLQLQGFEAMLGEMELLVIMYRTGYPTRLRDQQLSLRIKLKKLYDGMRFTDSIYLQHSQVSKLQKRTADMDTLYVTLKQIPPSELSVRQLNETCKEVIELLLASQIGITYPQNPSNYDIAKNVYANRQVKSGIGTLQNSLSEMLDGLKELIQTCHTEQELRKHIEQTKVIAGRHKQLVQAQINSLEHHPVNVTARMPLSRLDECTSNCKASVERPLIFCIAGQEKLLQSSNELSMVYEKELDEITTLSDQLATAQENQLIHLNIIRTRAVWEAYYEENIKLLEVLFDQLCSITKSCWMYANQNLHHEPVDLTIWNSDKVVKLMIEEQIAFEVFQKEFFRLADEDQDLQLILSDAETRHERLANVQELIFLAQDIQEERMKQRSQMNDVTKTYEETQKLTDDIYNGLMQAISEAKSDESVYVVDMAKIQDSLTKFEDQCQLAVLYPDCYQHTQLPQRYSAELNISNEEARRHVSHTQDNLYQSVTRVLEAHAVYRDLLSLLHESRRHQESCTNLLTYIDIPDNVTLHDPALINHNTILTLVQCSRAQNQRTDLQDMSKNIIDQLEVLSDRASQLQGQNHWGLSFARHISTIMETTNNLSAIDKIVQTAITLYARQNWESLWIISKEKLEQCIILLEVIHGQDKSVPAESRSQSIDGAEQQFRFITQTDVASSNFAFRNLSKCYLCISQSKVILQKLQQKHGELRRLASKIEWLLAKCRGGPNDHMNSRVRKLSTPTALEGRARKISLPSRKSSNSLSAGGGFDGNLKASRSAVISNQPRMRQNSSSRVQNRLRYIPDPANDLDVEVGRIINESPYQISVKAVPGEVGRYWFGEVQPRLAYCRILKSSMVMVRVGGGWTELTQFLRNHALLEGNFIPRERSLTEDEELREGYIRTNSSRTSNTRSEHYGIKDGNRFIVGNGIEVKMTRAQDERTVPPRTSRTNHLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7Y5</accession>
    <name>A0A8H7U7Y5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2175056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7Y5"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2175056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="100" mass="10816" checksum="4FD1E906A92973A3" modified="2022-01-19" version="1">MAAFDVNSFGSTNSVFLPFSVGVVQAFRRDFHNFKGLFSRGVESTVSWSIWVLESGMLGCISTGSESDEDSFFDSTTLGSSEVTEFSVLMSSGNEGRFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8F9</accession>
    <name>A0A8H7U8F9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CNH-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_001428</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF2">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="664"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="5">
        <location>
            <begin position="1052"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="120"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="373"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2171952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1372" mass="155119" checksum="B1A4902F4E4F7FD4" modified="2022-01-19" version="1">MAADGSQYPQPPPPPPPPPQQHQHPLNRIPSSPHYTSHRQAPNQNVARSTSQQQVIGRAARQSYARQKLPMRVQSLASYANNSSVGRLPQHGMSYQRSSVTSYGIPNSPPPRYELVSRPQIPTLSAPPPPRHSSYGVAAPATASSSVPTSSSAQYAASPQVGSSPSMNGRLNTKPLPPTHGQKSLANQQPVVNIQSPTINTQPLPSNQPVVNLQFTANGSAPQVNLPAAGTQPLPPTKQQLTVNSQPPQVNQAALNHQPQVTLPEIPVHIEHASPANQHSRLPARTSSIPMRQDEEEFNFRGRPSSTLIQVQPVPDDAYSPDGDEVSFADHQGEFMALGHGLGALEKPLPKVSKSESTAQADRHIEMEVEKLAIGLQDKERPRAHTRSSSVGITQQNKNETDKDYSPSSPQLKNFGERSKSFSYGTGENLATEAKQKTRHQKRSLEQRSKQPLVYGALLSQVAMEMQKRVVVGERLKDNIQYSNVFDGKEAVDKLAFVLRTSDRTLALLVGRALYAQKFFHDVNYEHRLRDSNQELYQYREHLQLPYADQQEEESDRPPESPFPDDETVALPLSAEPVDHQDVAYPNGVFTLLTKCYSPTCTKDSPCYSISCPRMAEKSREDTFYENSLSRSVSRSSLHEKETELWIESVPMEVTESVSHQERERQENIFELVYTERDFVRNLDYLQKFWIEPLITTDIIPEERREFFVQEVFWNVRDIYNVNINLCEALLERQKESHIVEQIGDILLQHVSNFEPFVVYGAHQIVAKHMFEQEKTRNSRFAEFVHETERKPESRKLELNGYLTKPTTRLGRYNLLLREILKHTPEGKPDGEVLPRVMDIIKDYLTRVNSETGKAENRFNLQQINERLSYKNPSDGIDLRLLDPERQLVMKGKLKRKGSGSESSEVQVFLFDHYLVFAKIKYMPTGEYYKVYRRPIPLELLQSNIPDSVGHKRASSILPYTRTAMSGNSIYGLKSSASEINLNHSSQSKTGGHAITFVHLGRKGAPPYTLYVPTMTQRRTWLDKISRQKEALTAKQRVFEVVTLSERQFISTNRVHHTALYDKQLVLAADHGIYVGSSKEGSTLTRILALEKATQIEIIEEFRLMFVLGDKTLWSFPLEALSTNDPAMRRGKKISANVPFFHVGSCLNRLLICVVRSNALSATTIRTLEPSSVADSKKSKSAFSRLVRGNADSLKIYKDLYLPSEASSINLLKTKMCIACAKGIEVVDMVSFEVQALLDPEDENLQFVFGRQDVKPLAIYRIQFAEYLICYNEFAFYVDQKGRRKRTDWRIDWEGTPESFALHYPYILAFEPAFIEIRNIETGAMEQLIAGNNIRCVQNNSKEDGIIHGVMDDPKTESFQFLFQLKPIPRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8I2</accession>
    <name>A0A8H7U8I2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_001534</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8I2"/>
    <dbReference type="OrthoDB" id="10249311at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047860">
        <property type="entry name" value="Ribosomal_eS12_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01189">
        <property type="entry name" value="RIBOSOMAL_S12E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="31"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2172057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="149" mass="16371" checksum="CBE3476D7D7B5248" modified="2022-01-19" version="1">MSAEEEHMAVDAQEIEVAADATKGQMSVEEALQEVLRRALIHDGLARGLREAAKALDRRQAHLAVLVETCTEKEYIKLVEALCAEHNINLIKVSDAKKLGEWAGLCKIDREGNPRKVVACSCVVVKDFGEESEAMNVLLDCKLSQVIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9K2</accession>
    <name>A0A8H7U9K2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHF complex subunit HOOK-interacting protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_008198</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FHIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9K2"/>
    <dbReference type="OrthoDB" id="5350595at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019384">
        <property type="entry name" value="FHIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045669">
        <property type="entry name" value="FHIP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705:SF11">
        <property type="entry name" value="FHIP FAMILY PROTEIN CG3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705">
        <property type="entry name" value="RAI16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19314">
        <property type="entry name" value="DUF5917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10257">
        <property type="entry name" value="RAI16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHF complex subunit HOOK-interacting protein C-terminal" evidence="3">
        <location>
            <begin position="660"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="619"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="864"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="922"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="622"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="864"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2171818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="986" mass="110974" checksum="2E4A15A82680893F" modified="2022-01-19" version="1">MDYFSKFRKRIVTPKAQPTGAMQLAKFHKCWNYVHNIFAAEDKKTNLHVQQTDIPSRLRQMVDLLVDEGARQEDSSTGVCMEYFLKNGILHFLVNVCEKEDYPVGMRSETIRTVAGMIDLLDDRFLVQHAVHKPTIRLLRFCVMEESQSDSYDEDLVDLMYIICSKIHGFPALLNIFFHDRQWLTTPQKPQHTTAPETPDHMPGQDNPLSIHANGNRANDKKPDYEFVLFTYLLRFVHREGKSGDFARTGLLFLMEMATGQLADFILESDFATIMAAGLGALYSQLPRKLVIEEEADLANGSASFLLASVPDDALGSPFGIDIESSNSEDFRGRLDSFLKLLDFCQDVLTRCPSVEISMSLLHNIRSIFLENILYPSILECSDTDGSAVAVISYIDMILQTLQQEELVDVVVGFLMAVNDTQSDSRLNSPQVEKGSMFGDGKQISDIYMGIEGDKIKSSPYFTALGRFTLKDLIFSRLKSSSQPTVIATLKLLRTLISQHCLYSLRLLSIGFDDAATSFPPKVRFAETNNEVHSHMDKPHTTTISHHNREIELFFSLICTIDYPHSQEILSLGYESYITDAENMILGDPCYQNGITAGNDEAEASLQRQSKLEKRRSLKYGQRYDEKRTSDREASKSKLKTKSSQLMSQVLPKHRLKQTDPLLQILLGLLSHFFAQSSELNLALTAVFSALAVCPLRSLEGWLAFNEEDRATDVLVLGADQTSAERHSSKPGNKIRVNDIYAQFDKDPTPVNEDDEDDDRSIDFALDRNSVYMTAATNFRSFPPIFTLLRTLTQQVDYYRSEISQFDKYLEERRQCLFFGDEMANLDISDTETNSAANKPSDAQNSSAMSLFFGVGVGTKKQSSKAKAAANTQQTTSPMANSSTVPISDTLITHARTTADIRIQPLFPSNFIVEPRETILDLNDDDEDTFAPKGRNPSQPKRQDKSTEINLSTLLNNVVILEECIKELVALIQVRRSMGIDEILYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9Y7</accession>
    <name>A0A8H7U9Y7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_004779</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9Y7"/>
    <dbReference type="OrthoDB" id="29773at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012404">
        <property type="entry name" value="UCP036436"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036436">
        <property type="entry name" value="UCP036436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2172238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="44725" checksum="18D8947E545D1B23" modified="2022-01-19" version="1">MPKPNATLVLVAGMLVSGVANTILNKLQDMQCVENCSDPDPSKRQYFEQPVWQTLNMFIGEAAVWSVYLFQMWQTKRIALQDHVEEVVPSAVNQLDAGVVVDDADRLLKNSEHDEQLTGWKNFLFWIPTICDLTATTLMNVGLIYTAASVYQMLRGAVVIFTGVFSYFFLKRRMTRWEWISLFLVVAGVTVVGLSSVLYPQEKPSTFTSDDGEIPFDWESFLGVVFVLGAQILTATQFVVEEKIMSRYQVKPLRAVGLEGTFGLVSVLTGMPILYAIFGNSRPYFDLPRGWEQVSTHPTVWGTGIAIATSIAFFNFFGLSITTTVSATARSTIDTCRTLFIWMVSLYLGWERFSWIQVLGFTVMVLGTFIFNGVIKPPFLQPRESAESAPLLRDEQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UA38</accession>
    <name>A0A8H7UA38_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Scaffold protein Nfu/NifU N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UA38"/>
    <dbReference type="OrthoDB" id="565552at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000001">
        <property type="entry name" value="NifU-like protein 4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="2">
        <location>
            <begin position="66"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2172388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="271" mass="29609" checksum="799C17EA539E1F46" modified="2022-01-19" version="1">MSSRIALNLLGRTAAAGLRTRITVTKPLLSRGIALGRLSAVNSVRPSLATSRLNGPAISQVRTMFIQTEQTPNDDALKFIPGVPVMESGTAEFLDVRSSLQSPLAKQLFQIEGIKGVFYGPDFITVAKEAGSEWQLMKPDIYAAIMDHFASGQPLIKEGSTEPSDTTILPDDSEEVQMIKELLDTRIRPAIQEDGGDIEYCGFEDGIVKLKLKGSCRGCDSSVVTLKNGIENMLMHYIPEVQSVEQVLDEYDAVSLKEFDRLEKSLGEKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAH8</accession>
    <name>A0A8H7UAH8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAH8"/>
    <dbReference type="OrthoDB" id="60858at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919">
        <property type="entry name" value="PROTEIN CBG05606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2174397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="183" mass="20640" checksum="AC8D70F8233F0661" modified="2022-01-19" version="1">MAALIKQTKPAKWIILWFTVSSLLVLWDVGYCLMRPHSMFNGKYNWLWRPYNLYAKVDHFYGPEAIAANDGFTAAQSWLNLIETIINLTYVKMATDKQTNLGVANLVGFSAAVMTLSKTVLYWLNDACSGWSHTRHNDLQSLILLWVIPNGAWIVFPAFIVLALGKDLKSRLQGSTASTIKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAU9</accession>
    <name>A0A8H7UAU9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAU9"/>
    <dbReference type="OrthoDB" id="10319675at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="950"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="981"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1020" mass="113780" checksum="FD0D1DC45ED44517" modified="2022-01-19" version="1">MSNNISSHRHQDSSASRHEFTSPLIPRTIPLDPPSAGRSGLSSRRRFQLEADMRRESLAFFRKLDHGHADVSFDLLSNEWNEMINDPLIDHDADSPIQKVKSVRRPMQGRALSSYRPANALNSTPIRPSIPLFKSSPFAASPKLKYDGDTDNDTSEFDTIGPPALSAGSLKALENLSPMQPPRARFDLQSETTEERPARVTIPSQQASSFPPGSPSERKGRVIVAPTAPKTPERTKRPSSPIRFTRSSPNKPFPRSSLGTPRGFKSTLKPSSPRSQTLLNHYPDTPTRQPVNIARTPARIHEYKPSDSPEEEQPLSPPKLDFEGVLADYNDPHSAENDNSLSIPLSPAERCSSQPSQEPQSHRSNTHISPNRLPNTSSSQTNFGDSPNRSIDEGVFLISATGQSQTRSNDPQSALPPTLSTDEVIDREIQGSPNKSDPITPQKAIRTEDPGSASSIRKVRDFWEKLSVSSAEKLASVTRSLDIWSPSINKQTSSTSPLKRRISSGDRDEQRKIQKTSDSIKSTGSGDLSPPSTSDNMLYSKLRLHNTHASPAHENEESDDKENKLVAGDFRKSISSLPMFKETNSPIARRRTEEFGKMVTPDRTDMGKVSSKSVETQFTKRHLARNLFDELKSQPLPKLRPVSDRRTSRNLIDALGSDDTTTTEIVRKRNDFKQNFHKFEDNIKQSEEVNGSPGQETSPSRDALNHHISPISRTSHKSPAVKKHSTDDDDWVVPYSTKQLQKSSNTNTYSLSPARVMSKSPLRDRYNRFVSPKRPMSHKVPETPIPQTPKSAMLFAERKLTRGSGLDYASLPTPVKPSAARFAAGRHRAERKPEQRSEPADENVLYFKPERDEPKVKDYRPAATLMNRHEKPTVDFAAEKDQTAVTVDQKADAVMTRKASPTEKVNVLSSQVQKHTESQLEATVEGKAWYDEREQLDEWDDVPKHSAIVEAVNQQPPQEPKTDTTTPAMTGSFAAAAKRKRESDAASDRQRTKRKVNKIPPAQRPSRIPLATWRIAKMNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAW8</accession>
    <name>A0A8H7UAW8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAW8"/>
    <dbReference type="OrthoDB" id="10252077at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027819">
        <property type="entry name" value="C9orf72"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31855">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE C9ORF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31855:SF2">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR C9ORF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15019">
        <property type="entry name" value="C9orf72-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51835">
        <property type="entry name" value="DENN_C9ORF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="738" mass="83324" checksum="070586C60428786C" modified="2022-01-19" version="1">MSERKRPVLKPPKSKATSTTAAVNTLEVTTKAVVSTPVLEEEPELQDNATTPTVDSPSPRRKHRRAQHQHHHLHEQRSLSDVGEDLHIDTQRRIMRSRGSTNDGGSIADASWKWKKDHDLDEAVDNTLKPEDALTMGRSPTTAQHCTLTDDDFHHPSEAMAALKDAASDSTVEPTLSNSRNKNTRIRPSHARSRKKPPFPTRRMHSYLESISGHTFDVTSPLIQQGSFSSAMEGAPHLNLPDSSFFSAVMLIKWSNVMGPEVEKVWTQGDQTAQSKNATYASIAKQVLNGEIGRNILEIEPKFLVLGDEGVICTSFLFAEYQANTSSKSSTSSPNRSSSNITDRQLDTNKISALVFLVPLQYLRNFSNYFDVMVDRVPGLVEKLRRLRLSVNTPWPTLLNHFTSVHLVPFVQSIMDLESVSLPKDCLKISHTILGMESRRMFDNDFVARLITSHLQTHGSTLVVGSNITTMNMVINTLALFLFPEERDRSSHTRKEHQYMPDLYAQGVLAQVVDQMDVNLDFLVLESPEPTTLVDLTRLTIEQTAVLPEYSRVRTEFYLLEEEQLEESNLGNDSSSWRIPRPDMENLDWIHQIFHTAKGIAPCVATMLSEIDKMPSTMREAYVRQWRRGLLRKALAVIKFLEDQIDIDVLLQSRRRRELKLKASIHNSDAANISQKQSRSRTNSTSANTVALMRQVLDLQDDYDFSIVLSQAEKLKPGIIEWVTVYLQSRLLPTSQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCS9</accession>
    <name>A0A8H7UCS9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_008440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCS9"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="451"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2180861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="56495" checksum="59914BED38C982B6" modified="2022-01-19" version="1">MSETQPLLSQPQTTSRRFSWLRPRLSLPPANTYYVIPLCVALGIMVGMTQAPLVQFVVGLVCNRNVQSLWDTFHIPNTAVTTNILMAGRPREQCEADPNVQALSSRVILVIQFCAALTSLCTTGFYSALSDKKGRRLVFAINAAFFAMETGCNFFIARNAESLPIAALFCTAILQGIGGGASTVLMGTHAYSADTVPPQRSYSLACSSVQLLEASLWRYGVEKFGDIQIVFLANCIIFTTWLLVVIFILPESNKNVLGQQHEFDIVEESTSAVTGEGEPPKVGILAAFSIIFVSRGPGTSRFTFPALVIAHWFMMMQAMGIQTVIVLSATYRFHWTPANIGAFLSTTNAARLVGLLGLLPLLARFNRRLVKRRGERKKGEEMKTAQHITFDLFLVRFGLGLDAIALLLQGLARSGWTMYVGVLFQSSAVVYAAAIKSLVLHLVPPEQAGSALGAIAMVEASAHLAGPVIMGTAYSAFVKTNPSMPFYVAAAGLFVGFALVCYVKADKPAKTRTPSDLETDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDB1</accession>
    <name>A0A8H7UDB1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDB1"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF152">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="336" mass="37212" checksum="88A7364B1F51D7FD" modified="2022-01-19" version="1">MKFDREIDFPASQKVPLHVDAQNLQGKTLLITGGNSGIGLESAKQLAKMGPDKIILACRNMETAAQAVEAIKADGIEDVEAWELDQSSFDSVKAFTKRYNESGLDLHILLANAGVLPMKASRTPELTNDGHELIVETNHLGTALLTLGLLPTLRRTAAKANEHQLPRVVIVSSDVHYWTEFSPSKQEGNLIKVMDSETSWEDVIVRYYDSKLLNIFYGQELGKKLQQSQIKEDKQIVVSIVNPGLVRSRAEIEDPNSRLPAGMRELARDYTQGCKTHLFASIDPSAGKPGEVVYYTNCAPVEPADITLGKEGDALRERVWKDTLQVLGVTVQDFQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDK2</accession>
    <name>A0A8H7UDK2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Octanoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.181</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_001879</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>octanoyl-[ACP] + L-lysyl-[protein] = N(6)-octanoyl-L-lysyl-[protein] + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the LipB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="6"/>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDK2"/>
    <dbReference type="OrthoDB" id="19908at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000035">
        <property type="entry name" value="Putative lipoyltransferase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010925">
        <property type="entry name" value="PRK14345.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993:SF7">
        <property type="entry name" value="LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993">
        <property type="entry name" value="OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="10">
        <location>
            <begin position="59"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="7">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="104"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="171"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="184"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="9">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2179030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="267" mass="30056" checksum="A5B804BCAAC46AD5" modified="2022-01-19" version="1">MLRRALSTACPSSIPRAINGTLPYLKLGTVPYGKALALQRHLVQRRHELNNDTTSSTDSSIRDILLLVEHPPTFTAGRRFKGRSELEEETRLKQLGAEYYETLRGGQITFHGPGQLVSYPILDIRDYQLNVRCYVSYLEKAVIETCRRYGISAKTTENTGVWVDDNHKIAALGVQLQRYVSSHGLAINCDVDLSWFDQIVPCGLADKRTTSLSDQLKRKVTVDDVIPEFVDSFGVTFGRKMVDANEMQGGQLLEEEIHDFLAKNEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDR6</accession>
    <name>A0A8H7UDR6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDR6"/>
    <dbReference type="OrthoDB" id="5382203at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="800"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="897"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="906"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1052" mass="117014" checksum="BA481EC615D4A8EA" modified="2022-01-19" version="1">MNRVTTRYISPNAANAIISEVGPYRISTDALQALNQFLDEILGMLLTKAQSLDLSRIKTVALQLLPSSLGKNAIVEAELEVKTLTETEVIDYEAYERMRQVGADGHFPLQNCIQQLRDRCLYYSTLAERDMDQNADANSDKTMISPILAIYVTTIIEHLAEYLLTTVAVAAENEDTEFVRVREVFTALVDDTHVSDSFSKMELKERLEKRLVASGFRLKRPGTPITFTPLQKPVETKRQDFNDYEFEDDEEYLDSNGMTVPDKGSRTPVASMLNSRTNTGSTYRPTSVLSSTPSSLTVNSAHGSINSKKTFKLFNKNNSRHSVDFHSFDSQPTVYDPEAPGLNFEDLIRSGSTMKMSLTPNRLRSIEIEDQASPNGANGDNWARKLPSIRPESPRMRPKEQPEKKNTQRSLPNNNGSNRPPNLARSSSFSYLEMPVPSPSSHKPSSLAEANQKPALSTMFDLPLDFLANPASALPPSPKQPTANRNKPQPFPLAQPQPLKQSTEPSIPKPASNVKNDVEQKEAQQAVPMTLKATPATIHAAHKKEVEKPKERMRPAPINASIPADIIANDTQSKRLPSKPAPTTPVNATQSERQEIVRNILQEAQHSVKADTTKTNPPHNNEPTIVRQENKDMSETDAPIRPPRQKPVAAKITTPIRSETIRASSDPIANKAATRSEPTLVDSPTTFSNKGTEAASIAAQKPVDLVIKPRSNSTSNYARKREPTVNGSQESLTKTPISLTNVPPSKFEAAKTSKRHDTLPRPKPELPKSYSEDNIVVAANAKEPEKMESEERLIPVPSRAQTLKEKASESRAVARPSEASEERRMSRPATPDRRSSMIISPERPSSFVAKRRSMSGTLPVTDQPKLNGSVEKSVKVWDDYLNQNANRTIIRRRSQIRPETPTTNGVDDDINNETDDGVKETKEYKDYRDARVPVIPQGVLEKVRKFERQRQDFTMLDSTEAVKQARERIAASRKAVRMSLYRTVAVDASTQTDLPAVDQGVQAGDETADVSEIAESEVSERGVIDGDEEWFMDEWDEDEEDESTVAEWLLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDT5</accession>
    <name>A0A8H7UDT5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Copper homeostasis protein cutC homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDT5"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="entry name" value="Copper homeostasis (CutC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00795">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="CutC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598:SF0">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="CutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2181986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="357" mass="38536" checksum="4029A1F65556D196" modified="2022-01-19" version="1" fragment="single">FTNNIRLNGMHGIVQILHSEKGNTIQIDSPINPTAGSRLDRQAVPCFTVNAPSFSRGEDLHIIRRVSVIGFLTICALFEICVDSAAAALKAEQCGADRIELCSSVKALGGVTPSAGSYGMMARMDHKVAHLTAVFIQPHLSLLKVYRSRGGDFLYDELEFESMIEDVKFAKEAGAHGVVLGILTKDGEIDLERNKRLISLARPMEGKLIGIFAVNSYRALILICSSVTFHRAFDMAADPHVALDKLIEIDADRVLTSGQQKTALQGAELLADLQKAAAGRLIIMPGCGVNEKTVGDIVTKVQPKEVHLSALKTIVGGMAYRNVKASMSTDASSDQEYSIDIADGDKIKAVIDVLEKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEB0</accession>
    <name>A0A8H7UEB0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucuronosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_003578</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEB0"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034187383" description="Glucuronosyltransferase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="511"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2179795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="61224" checksum="C6B08DBD84CAAEBB" modified="2022-01-19" version="1" fragment="single">MRLSVLLIGVAAYHVAAVLASPFVHQLDFRTPKNIGISVLAPGSSHTVWVLEIGQELARRGHNVTFLCKIENEKYTKDYPDIKLHSAGKSHFNVDLDEMSKSATGKDFCIDNTKAFFQAAQSGFREDYLLHAKYMQEQRPDVMICDMLADACVRATDEYNIPLALASTLAHGSDSDAPFVNDFFLGADPTTEHESIWTRFNNKFIFTAKLMWSLKPVLEEGMQARKELGLKSASQIFAKKIDHSIKLVNNIWGMEIPRAVGPLIRFIGPIMQSKYPNMDFSTSQFLDTHQKVAYIAFGNHATPTPEEFAKILAALVDSVDSKVIDGFIWATVKASTFPEVVQTAKGQQLNATDIIYNPNQYPHYKFLKWAPQFAILSHPSSVLFLTHGGANSLYEGLYTGKKLLIHPFFADQPINAKKLTADGLALTNDRINLQVSAIRRDIRLLVEDEGNQFTANIKRTSNLVQLKASDAVSMAAAAVEEVAFASKGDKLPHLITGDHNMTYMKAHNYDLYLLLAIVLLFVTGFLITVIYMGIKFLLNAFAPKQKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEB4</accession>
    <name>A0A8H7UEB4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NADPH--hemoprotein reductase</fullName>
            <ecNumber evidence="12">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_005538</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="12"/>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEB4"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="14">
        <location>
            <begin position="580"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="784"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2176304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1188" mass="133213" checksum="82592D4D868AEBA0" modified="2022-01-19" version="1">MSTTTLIVAIKGTDNVERDGAIVRLEAGANMETLRSRIAEKLAIANGIEELILEDTNGDSLTTIDQVCKQQTVYVNLADQVKLPAVPAGTLPYFGNLYQLLPDMLAGWRKLFDEYGPVVKVNLLGNEIIGTNDPAVAELWVKESEYFTKKIYGGLQEVKAFGGQGLFTTDSDDMDWKLAHKLLMPAFSPRAMKAYQHEMSVIGQQTVKVFQQYSPDEEVEILHWTTNLTFETIGKVGFGYDFNLVDDRYADNHPFIDAMGYCLKQSFARGTQSKIIKYLPLEVNRRYDRSLNLMHSVVDEVITERKSHPHASEDNKDLLDFMLTARDENNLGLSDENIRDQVITFLIAGHETTSNTLAWTLYELSRHPEIEQKILQEVVNLGITPDSLPTSEQSSGMKYTYQVLKETLRMYSPLRALAKYCKKDMVVPGGYQIKAGDRVAVQLNSLHYNEKIYPNPAQYDPNRWTPEEEQKRSRFAWLPFSTGPRSCIGMALALQEAKTVLAMILLKFRFVYDGPPIGYDPKSPTIRPLNLMMRIVPRDKLPSPTADNKLTPVGSPNLNKAQMAMPTAATNVGTAELPPVFFLFGTQTGTAQDYASQLASQAKSFGFKDITLCEMDKWEVLQSGRYNGAKKEKDTRALVVICTATYNGSPPDSAENFDKFISDTSKDDDLPLNGILYAVFGLGNRNWRTYQQFPIKCDSRLDELGGERFYDLGSGNADKDMDGEFHDWSAHFWTHTLTYYGIATQEGSLVPGQKTTEDPTSGLEIRFIPPSESEAWNKADKNVNGDYNAEIQVNRELQNVERSKRSTRHIEIDISKLQSPDTDKHRYITGDHLEVYPENADNVVETIALGFGLILDSVFEITSVDKSTVSSRSLAACITGPCTVRNALKYYADIYSAPSRYLLAFFAARLQNTHPDVATSFSDVIVPGEKGQKAYNEFIQKYRNLLDLQRGFPLKELDLKEFLCATSVMQPRRYSIASSPLKAKDTAYLAVGVVDDIIANRHYYGLASGYLARSQPPTPLRARIKSSKSTFGLPENPETPIIMIGAGTGISPFMGFMQEREVLKSKAEAHLFFGCRHPDEDFIYRSVFEGYEKSGVITKLYPAFSRLGEDNPRKYVQHQLMANAGKIWTLLTNGANVYVCGSGPMSKDVRRSFELMAKSFGGAQNDDEACEKLMEFMSAGRYNEDVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEI0</accession>
    <name>A0A8H7UEI0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEI0"/>
    <dbReference type="OrthoDB" id="431202at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022127">
        <property type="entry name" value="STIMATE/YPL162C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735:SF1">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12400">
        <property type="entry name" value="STIMATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2180020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="40596" checksum="09B50636FFE38ACF" modified="2022-01-19" version="1">MFWDESKILGQFLHFKWRQCRSSCYLTNPLMPPDLLLPRAPGGEDTQAGCKLLDSFAIVIQLSLAAIAFSTLIIKRQRENPQRPLRIWSLDVSKQVVGGIVIHSLNLLVSYISGTNQSDPSNPCVWYFLNIFVDTTVGVGILWAILIGFKRLAHRLQLQGVDSGVYGDPPLTDQLIKWGKQLMIYNISLVLMKLVVIAIFAICPFLFTFGQWVLEWTMSDYKLQVVFVMLIFPLIMNIIQFWVIDTIVKHNERQEISLGDQNEEDEIVNLLAGEDDTELDEHHQDHTMHFASTSQEDLETNTTSRFKPTFTVDDDDLESGHDAWDDDFSFHSASPGNSDNAHQDHYELHSSQSKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEJ1</accession>
    <name>A0A8H7UEJ1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003837</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEJ1"/>
    <dbReference type="OrthoDB" id="3824970at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14424">
        <property type="entry name" value="CUE_Cue1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="3">
        <location>
            <begin position="50"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2180050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="245" mass="27401" checksum="99446B5110A3C516" modified="2022-01-19" version="1">MNEGISIIVAVFVILVAMRWLFVFLIIGDLGAPQQSGSQRQRTNRPRHAVTPEMVETVRAMFPNIPVPAIRASLQTTGSVESTIEQALRDGTLPMPANVTPPRSPPGGNRNNQYTSGQSSSSVMGARQNDLVSRYGLEARIDNLESPEPPKVWETDVQKRQEMLRKRKEHMILQARRKMQEPKASTQQPADTMSHSSKAAEPAESSSKTDEFDELSVEQLNALEPSERRRNMMEAIERRKAKPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UET9</accession>
    <name>A0A8H7UET9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_001851</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CitM (TC 2.A.11) transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UET9"/>
    <dbReference type="OrthoDB" id="442352at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43302">
        <property type="entry name" value="TRANSPORTER ARSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43302:SF5">
        <property type="entry name" value="TRANSPORTER ARSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02040">
        <property type="entry name" value="ArsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="606"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="637"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="688"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="732"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="9">
        <location>
            <begin position="249"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2179002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="758" mass="83380" checksum="A89EF1A7277A5FA1" modified="2022-01-19" version="1">MSSSALSTLRLAGRAGGRLLQPYTRPSVLRTARPAIYTRLPVMSSHSFHMTAFQAAEAGDPMQGIDPNHPFIQQLRKNPHILEQLAEFTVLLQEKGLDVSSGKQPGFGQIMKLMSDPDIKANAAKLAQDMQAAGIQMDMNSVMELQKAFGGPRSGSEDEESTENKGLLGKAKGFFKKQKNVPTAPLVLYFQSQHFNVHSTKVKLMAENSNLNAFSWVALVTFVVVIVFVIFPVSVSLRICGKPNWRFKLDLATAPILSILFLMATTTIPPWVVLRGFLGSAGIQPWGVMILAYICISLDLTGMLQFCAFWISKRAGTNGRTVFTAFFILTTVMSALTSNDVVILTGTVFLSYFTRVSDIHPTAFLISEFTTANIASMALYIGNPTNVVVSQAYGIGFLEYSAWMLLPTVVCTILAYITMRVLFRNNKYIPRTITCPDADPKSVLVDPFGAVFGVILLGCCLGTLIGTSFIGVEVWQVTLPFAVVMLIRDVIHDIDGNHGILNRIRNRYPRRKAQSVHSDQAVEDQVVETQIIPLADLSGAEHAPPGLSTSIDPYTQSPSKAFSRTNTGLASLSTIQNEQIRPKRVRDQFPTLYAIAMRMPWKILPFALGMFILVEALSDLGWTAIFAIALARITPDYVSAVFAVTFISLLACQLLNNLPMTILFTRIMQHPNFTTAPNVTPVVLKGCIFSLVIGSNLGACLTLVGSLAGIMFDHILKTKGIYVLKYFQFLKWNMVIMPVIATGACCVLVGELWYEFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFL4</accession>
    <name>A0A8H7UFL4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_008803</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFL4"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="5"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2181220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="503" mass="54997" checksum="247594AC86B5C32E" modified="2022-01-19" version="1">MLIFATLYVSMAAFNFGYDTSLFASIQGMLSFTDEFGTYNPHQKRTVIPPYLSSIMNSTPFLGKLIGTLISSPIMERFGRKSALLAIAFISIVGTLLQCTSYNVIQYTVGRILCYLGTGITISVVPAYQSEASPAELRGALGATLQLWIGVGQVLGSVITNATQAMPGREAWLIPTGLQFILPVLLIVGYPFIPESPRYLLAKERKEEALAALIRLRPSNTNPEDVEYELELISTTNQAHGKGPWRDLFKGTALRRTIIAVGVMMGQQITGQTFVGQYSVVFYQAQGITNPSPYLLGVIGTTTSLVASLLVSVIIDSFGRRKILLVGSIMIAIWLFIFAAAGSIVDPTQVQKNVMITANMLFGKSYGMSWAPLSYVVMAEVASGRLRDKTVNLATSVSVIMTFLVSFTLPYLLNAPYANLQSKVGYLYGSLSIVTFFFAYFFVPELKNRSLEEVDEIFESGISARKSGSYVAKGVGKKITEAENLEVVVDQKAEDAYDSDRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFN5</accession>
    <name>A0A8H7UFN5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha,alpha-trehalose-phosphate synthase (UDP-forming)</fullName>
            <ecNumber evidence="4">2.4.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">UDP-glucose-glucosephosphate glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_003401</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="2.4.1.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFN5"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1020:FF:000001">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000007">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000035">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012766">
        <property type="entry name" value="Trehalose_OtsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011071">
        <property type="entry name" value="PRK14501.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02400">
        <property type="entry name" value="trehalose_OtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2178148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="769" mass="87340" checksum="23CC7AE286D9FD33" modified="2022-01-19" version="1">MSEDATALQQNNKGLRLLVVSNRLPVTVGRDPKTNDFTFKMSSGGLVSALSGLKKMMSFTWIGWPGIDVPEHERKHMEDRLLKEHSTMPVFVNDDLAEDHYNGFSNSILWPLFHYHPGEISFNEQWWEAYQKVNELFAEAIVKIVEDGDLVWVQDYHLMLLPSLLRKKTKKDIKIGWFLHTPFPSSEIYRILPVRKEILTGVLEADLLGFHTYDYARHFLSSCTRILGLSTMPNAVEFEGRNVHVGTFPIGIDPEIYTEGLRNESIQKRIASLKERFQGCKIIVGVDRLDYIKGVPQKMHAMEVFLSQHPEWVGKVVLVQLAVPSRQDVDEYQQLRSTVNELVGRINGQYGTVEFVPIHFMHRSIPFDELVALYAVSDVCLVSSTRDGMNLVSYEYISAQQNNHGVMILSEFAGAAQSLNGSIIVNPWNTEELANGIYEAVTMPDDVRKANHQKLFRYVTKYTAAYWGLSFVNELRRVSEELGHREKIPELNQDQAIEQAKKSTKKRVILLDYDGTLTTLHKLPEFAKPSQAVIDTLKKLASKPNTYVYILSGRGRHHLDAWFSSTGVGLSAEHGCFYKHPASICDKIDPTSQSADGKVIKEEDGKWYCLVDQVDPSWKETIRPLFQHYTERTPGSFIEEKEINLTWHYRNADPEFGTWQATELQVNLEKLLSHMALAIVLGNKTLELRPSAIDKATAVRAILKDLQLQDIDYLMCIGDGKTDEVVFSLLNEIPNSITSTVGKKQTEAQSYISSVEQVSSFLDRLGQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFX8</accession>
    <name>A0A8H7UFX8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Caffeine-induced death protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIX23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFX8"/>
    <dbReference type="OrthoDB" id="5593818at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019171">
        <property type="entry name" value="MIX23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905:SF2">
        <property type="entry name" value="PROTEIN MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09774">
        <property type="entry name" value="MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="17283" checksum="F28E3554446C0588" modified="2022-01-19" version="1">MSKANLSPSTCYNLSFFKEMMKEYRKVDDNIMLRMNTTDTHSEAGCAEFFKQLAEAYQKREDTVNYCLKVMDEELDRKNKKLEDDPYDNNLKDAMYTEESKRRMVSNELMVEDIVRQRSLQVFRSKCRIFDVPQDIEDFLNKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UG24</accession>
    <name>A0A8H7UG24_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_000340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UG24"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF15">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="59"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2184431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="548" mass="60708" checksum="8C2DECA9D6AE0557" modified="2022-01-19" version="1">MDLEKKAIANVFETQHAQVKDLEDIPSTNSDSNSGKQTIREQYAKLFHNLKKDKRFTLWSLYVMSLVFGWGYDAGLSGVAIAYPQFRATYGNYYAEGDQYVIPAVWQSLWNAASTIGQVFGAYLSGQFADWKGRKPLLFLAVFLSIAASFALVFAPNLPTLFVSKLFLGLSVGFSTAIPPLYVTENAPANLRSVLSSLTNIIIVLGFFLSSLTGYGSSYIAGQWSYRVAFLLTFLVPSLFLLLLPWLPESPVWYMKQGEESKARVAIIKLFGPQVDVDARIEVIRAELEVGQGEKQDDSQGEKQSENAGGWKEIFSKQHRTRTLTSVLALQVQNFSGGYFANTYQTYYFQLIGKTDSFALTSISSALQFLANLVAVCLSDILPRRKALIGGGCILCVWSLIIGGTSLAETTNTAANTALVAFMLTWSMLYTASIGCFGWAVAQETAAQSTRPKTISFTVVCQQLTALMLSSVFPYFINPDQLNWGGKVMFPFVGAEAIFLLALFFFQPETKNRTNHEIDTLYANNIPPRKFDQYVVNGNVVERKGAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UG33</accession>
    <name>A0A8H7UG33_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_000370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UG33"/>
    <dbReference type="OrthoDB" id="342900at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
        <property type="entry name" value="MMS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024687">
        <property type="entry name" value="MMS19_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891:SF0">
        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12460">
        <property type="entry name" value="MMS19_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MMS19 N-terminal" evidence="7">
        <location>
            <begin position="46"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="MMS19 C-terminal" evidence="6">
        <location>
            <begin position="579"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2184461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="791" mass="87039" checksum="41CC27B4A9973310" modified="2022-01-19" version="1">MSSMDKHVAKYMVATGDSSTEAISASSEIVEIVNSGNTQTTLLQLIQSLGEYLTNEDGFIRAKGKTHYTTSCSFATDLLTNKLFFSATGLLSQTLANADQASINVQAVDVLVHFYCDRLSDETCVPKLLEGINALVSFDNFTDKSAMTVSKMLFDHIKAQSFPQVTRYNTFSILDTLVQRHALEMVALRAMNNEFVFGFTQVMDGEKDPRNLMKAFTLVREIVNNFDISNHVEDLFEVTFCYFPITFKPPPDDPYGITADDLKINLRHSLSSSPHFAKFAMPLLLEKLSSSSGSAKKDSMETIAECAPVYGANALLPNIDELFDALKVEIFHATDAALEDTALVAIHSVVAALSTGISNDGANDPFEKALKPLVVECMINLKDPELKNAQPAGRIMRAAASASDPASTLIIETVMPVLLRQYRETDIATQKKAVLDVLLEILEASKQLYGETSETVNTEDSDFQTPLLPYKDRLWEMFETSTTASNEYNGLRLAGIKGLKIMAIMKHYLSENEIGLAVRTFTAILASESDAELHQEALSSLLSIARIQTQQILDHTIPVLLDALPQSASDATWAAHRQTLETLVELSSIPAIFDVTGPSLVTKFQTASRQLPQDSYYAHAIIQSFYIIVKARTDKEYIAKWIKLVETLIADCVAVSTSTEGTSSILADNNLSAIASVVALVFQNLDATTQSEYINRMFDIYFKNDLSSLNIQVNSSFAPFEHSSSEAQKKTTILFNVAVSQYAKNLRLPIGSNEEFLTQLVDIALESSSSHQITALAQLHGSVVNKWTDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGK0</accession>
    <name>A0A8H7UGK0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGK0"/>
    <dbReference type="OrthoDB" id="10052260at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="141" mass="15847" checksum="F11BDBEDB8A91F0C" modified="2022-01-19" version="1">MTTLISEDTRVKVSSVLNRDTTNYGKQHLTDGNEETCWNSEQGLPQHILLDFGRGVEIDSVTVTFQGGFVGKKCTAQASLVESPNNYDQELGTFYPEDVNSTQNFSIECSQPVQRLKLLFEESTDFFGRITIYKLDVLGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHH3</accession>
    <name>A0A8H7UHH3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WRKY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_006249</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHH3"/>
    <dbReference type="OrthoDB" id="2362414at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.80">
        <property type="entry name" value="WRKY domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003657">
        <property type="entry name" value="WRKY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036576">
        <property type="entry name" value="WRKY_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03106">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00774">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118290">
        <property type="entry name" value="WRKY DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50811">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WRKY" evidence="7">
        <location>
            <begin position="311"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2183245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="384" mass="43729" checksum="16430FB3ADE6B84B" modified="2022-01-19" version="1">MQYYPAENNKADNTSNQSTSNPVSNRSSTQPSLEHFERPYNYSTRPVLNSTSDTEEMPAFTAAHHSAMPPMMAQDPFHTISTAAFDLQEVICQFRTQPELLQLILNSKVEEDRRKAEEAKLRGKEIDYYLQRRQSRDLSMDKPASTIHEALAPVHVARRDMIESSSQQPHAQNGSSTSSNSNDMYAKRENRSHRSSTISSPLSQGASMTGILPQPSSQRRHSAFESLIYSPNGEKRTSLYNGHDDENYPARKRSSHENSPRQSSTSPKSSDFEYMIEDESHVPSGQPGVFQNETKKKRKRREMQAVTTIVETRDPQNDDYLWKNNGNTLHKKTGQKSTYYKCSNSNKGCPVNKTVTLRENNTYLIKYRGVHLTECNRVKRIVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHK2</accession>
    <name>A0A8H7UHK2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminopeptidase P N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_006340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHK2"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000002">
        <property type="entry name" value="Xaa-Pro aminopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF1">
        <property type="entry name" value="XAA-PRO DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="7">
        <location>
            <begin position="6"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2183335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="447" mass="50075" checksum="6FE811B12F6DCE0A" modified="2022-01-19" version="1">MPHQKLPTATSVQKVINNLKKSDGIIYLKGQVLHERDDTDVELPFRQESNFFYMTGVNEADFHVVVSLSSGNITLIAPDIVEDHVMWMGLPDTPEQLKNKYDVHEVVYASQLEQVLQKENPEKIYTLSICDVTAIPKNLQSKVDKDSLQPAIYDARLYKAQWEVELMREINKISSDAHIKLMKEAKAGLSEQQLHALFVYETARKGAFFQSYNPIVAAGVNAATLHYGKNNGGISKDQLVLIDAGAELNCYASDITRTFPAGGKFSKEQREIYEIVLEMQKKCFELCKPGVDWEDIHRLALRVACEGLVKIGILNGDVEELLSKHIPACLFPHGLGHSIGIDVHDVGGYAPGVQRVDEPGIRNLRMRRKLEAGMAVTVEPGIYFCDYIIDPLLKDSATSKYFDLEKLNHYKKVGGVRIEDDIVITESGFDNLTTVPKEVQEIEALMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHN3</accession>
    <name>A0A8H7UHN3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_007019</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHN3"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000055">
        <property type="entry name" value="DnaJ subfamily C member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45188:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45188">
        <property type="entry name" value="DNAJ PROTEIN P58IPK HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="245"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="283"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="317"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="371"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="483"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2182092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="511" mass="56644" checksum="2076C0C8AC6DB829" modified="2022-01-19" version="1">MGSEPMDIDSQLSAEEIKTQANQEYKAGHYADAIRLYTQAIAASPNTSTYYANRAAALTMLKKYKEAAEDCRVATTIDPSNIKANLRAAKCHMNLGNLEEASRQYQLVLSQDAENRQAQRELYNLHQLSNYIKQADVFMENKQWGLASNALDRAIALADPDAVPFNWRVKKAECSLGQKNYSEANRLANELVRLDSQNPDALFLRARVLYKQGDNAKAIAHCQESLRCDPDYAKARVLLKKARALESQKEAGNAAFKSSRLQEAYELYTSALEIDSENEGTNAKLYSNRAAVLQKLGKYDEALADCNKALELDSTFTKVYSRRAACYMELEQFEEAVRDYKQLNETEPGNREYRSLLQKAELELKKSLRKDYYKILGVSKDASDSEIKKAYRKLALQNHPDKNPDDEKAEARFKEIGEAYAILSDPQKRQRFDSGVDIDGGMGMGGGGFDGAGVDINDVFAQMFGGGGMGGFPGGSFPGGSGGYPGGAGYQQQRRPNANGYSNGSYSFHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHW7</accession>
    <name>A0A8H7UHW7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Pheromone-processing carboxypeptidase KEX1</fullName>
            <ecNumber evidence="12">3.4.16.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Carboxypeptidase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Pheromone-processing carboxypeptidase kex1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_007262</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.6" evidence="12"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHW7"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF190">
        <property type="entry name" value="PHEROMONE-PROCESSING CARBOXYPEPTIDASE KEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="440"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="559"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="575"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2182332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="599" mass="67101" checksum="C98AB3FF72CA0C61" modified="2022-01-19" version="1">MLVSKRTLQRVTCCLLKDYYRHIEVSPEHNANIFFWLLNSQNVKSSNKLIIWLNGGPGCSSMDGMFLENGPYRVNPDLSVNISSGGWQDHANIVFVDQPVGTGFSFADTDSYVKNMTEVGTSFTKFLDLFFEIFPDRAANELYVAGESFAGTYIPYIAHQMLRENEEAGKTKYDLKGLVIGNGWISPRHQYEASFDFAVSRKLLSGSYKNIASQHLDMCRKAIASEELISIYICEQLLTDAIDSSTHIVNRKDNQMLCVNQYDIRMKDEPSPDCGMTWPHELTQVQKYLQDKEVVKAIHASKQMLGWTECSGGVHRALSGDKSVASFYLMPEILEKVPILLFSGEYDLICNSLGTEYLIGNLTWGGSIGFEHNEKFEWHIGDNLAGYYTEERNLTYVLVKDASHMVPYDKPTEMLDMINRFIGVNDGTVNGLHSWIGEKEVTGTPAADPEPKPTTGAGDASDNEGTSEEVEDPWSEYYNWGTSLLVVVILFACVAGFCWYRSSRAGNARLRGRPDFISKLIGKTGLGGRGKGLKLGQDRSDVNELDELVVETPTLFAAEDYSDDDDSNHGRYGRSSREGTRDHLLPNRSNFSIDDDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UK83</accession>
    <name>A0A8H7UK83_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-type lectin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_002653</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UK83"/>
    <dbReference type="OrthoDB" id="270293at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07308">
        <property type="entry name" value="lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000095">
        <property type="entry name" value="Lectin family integral membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF45">
        <property type="entry name" value="RE50040P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034678795" description="L-type lectin-like domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="8">
        <location>
            <begin position="28"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2186215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="312" mass="34859" checksum="685EF65F4C056036" modified="2022-01-19" version="1">MLFLKTGLLVLSAALGLTAAQNNAPSSSITLQTHSLYPPYIDDDLQNRWFDFGGDAIINTNKHVRLTSNRPSQVGYLWSRLPLATLNFEIEFEYNVDGPSGHLFGDGFAMWLAKERASTGPVFGSVNGFDGLGIFFDTYDNERSHKHSFPYVQAMIGDGYKHYENDKDGSSTEAAGCEADFRGKTVVTKARLTYYKNNYLRLELQHEKEDEWTECFKIHDVKLPDQVYLGFTAHTGEISDNHDIISVTTKTLPPIAIEPKHQIPQTGKKPKSSSGGGGFLWFLFKMVAAAGLVGVMFVAYRVYDKSGNMKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKA2</accession>
    <name>A0A8H7UKA2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002713</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKA2"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="53"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2186275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="497" mass="56231" checksum="E82BD8751E5E9D3D" modified="2022-01-19" version="1">MPVDHVDHVRSVDFEENLEKPRRTNTDHLKRTSSLFQEPKEERRLVRKLDLHILPLICFLYCFSFLDRVNIGNAKIGGIEESLKLTPVQFSVTLALFSVAYILCEVPANVLLKYFRVNIWISVIMFLWGGVTILTAFANSFITLSIARFFLGVFEAGYVPGIMYYLSTFYKRKELATRFAIFLSFTCWAGMVSGPIGYVATMLDGQLGLRGWQFLFIIEGIPTMLLSAACYIFLIRDVQDAKWLTTSEKELQVQRILREKATSTQHRPLTWKKFKACILDWRAWVMGLLLICGMTAGAGLSLFLPTLLQDLGYSLGVTQLLVIPINLVGAIAEISSAFTADRLERRFPLIFAGCLLGSVSFIALGLVQNNWVRFALMHFGISGVLMAAPCIMTWASDNWDGSGKAVSMAFIFCFGNVGGIIASFIFRPSDGPKYEMPFEVFGGMLFVAAFIALFLKTYWNRLNQRRDQGIYDVDFTELTEEEMNDLGDRHPSFRYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKI6</accession>
    <name>A0A8H7UKI6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKI6"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2182244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="165" mass="17694" checksum="DEE06851E6F4D53F" modified="2022-01-19" version="1">MFLILLRRPKQLHQINSKAFAFAYSFCNNVTMAWNCKCSANNNAANATYLEPVTLAECNGKFVACQAVCPADANRSTCVQACTSKWACGTANSPPSYLQTQSATDQPSYDGPPPAPAPAPSNSTQTNSTAPISTAKASSSQKMDIRHEFVALLPMVLLALFQVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UM37</accession>
    <name>A0A8H7UM37_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_000706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UM37"/>
    <dbReference type="OrthoDB" id="2385312at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2184793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="232" mass="26522" checksum="D4D4A56DE061F8C0" modified="2022-01-19" version="1">MSSVSKYSLSPSSSAAQSFSESASDVPILFILCSSKSDHNPLEHSLRPIVDIARSGMTHSIYNLLLQVPYTTETRYHLRDTLTDSIVVHAVRELLKSDVHIQALSSKTTVELDLKQASMFRRVYKFTWEGRSYRWELDRKQQLHLSRQKAGQQHKEYESIGCAKIYNPNLDQAHQTYSRFQLQPEAFDEIRDKLAFEHVTILTLCLLIDKIGSGFATFPIIQEQSSPPLYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCG9</accession>
    <name>A0A8H7PCG9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">mitochondrial processing peptidase</fullName>
            <ecNumber evidence="5">3.4.24.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Beta-MPP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_002951</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. Preferentially, cleaves after an arginine at position P2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.</text>
            <dbReference type="EC" id="3.4.24.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="5"/>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCG9"/>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000008">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000001">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="14">
        <location>
            <begin position="44"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="15">
        <location>
            <begin position="187"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2171329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="457" mass="49293" checksum="AE5E9EDC23954020" modified="2022-01-19" version="1">MASRLLSTAVKSHVGMAKQFVRPLATATNSVATRTTTLSNGLTVATEENPTAQTATVGVWIDAGSRADTAEANGTAHFLEHLAYKGNKAAQIESLGGSLDAYTTREQNAYFAQTFSNNVSQTVDILSEAVQNPDLAGLDQEREVILKEQQKLANNGQQVVFDHLHATAFQGESLGRPVAGTSESIQNITRDDLTNFIKNNYTGDRMVLVGAGNINHDELCKLAEQKFGSLPSGSSLSAKLSKKPDFTGSEIRLRDDTLPVASIALAVEGVAMSSPDYYAALVMQSVIGSWDRSLGGASLLGSRLSTIVDKHHLANSFMSFNTSYKDTGLWGMFFATENKTQIDDFVHFTQKEWARLSTTVTEGEVERAKNLVKGALLLGLDGNNAVAQDIGTQILATGKRLSAQEVEQAVSKVTVGDVRRVANAQIWDKEVAVVGHGPVEALTDFLRVRGFMSYNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCR1</accession>
    <name>A0A8H7PCR1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_009152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCR1"/>
    <dbReference type="OrthoDB" id="9942608at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461:SF5">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="372" mass="41716" checksum="A24F3523BB7A0A41" modified="2022-01-19" version="1">MSVNDTASLHNVFPNISLDVIETILESNSGNVDKTFDSLLEMSDPDFQDQPPAANQARKEPSTDSRKPRVSWSDSSNQTGHNSTIDHWSDNGSSYRRSSHQNEDQIKQDAELAQRLAQQEQAQSSSSAAPIPPASANTTWTNPRLQPPPVFGAPPPPQPPQSYTSHAYAASMPQPGQNPFNLQELRDQIPMIRSNVVEGSNMAKQKAKELYQQLKTKNMAKLNEFTNASSYNQSGSYGRSSTNPFLSPQYSQPNPPTPPRPNPRPQRYSTPPGNSSGRHRFQSDEPIARRHSDEAMAQLQADERLARQLADESRQQLQADEEYARRLADEQYQAVQQQQARPINPFQDEAEDELPPPYEAHRRDRPISDLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCS3</accession>
    <name>A0A8H7PCS3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_009158</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCS3"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034380616" description="SH3 domain-containing protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="99"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2171497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="201" mass="21806" checksum="6E95E2E532744C7C" modified="2022-01-19" version="1">MYGLLLVNLACVTVISGTPILHSRADASNEDESSYNPSAGNTVGESPTAGAGIGIGVALGVIALFAVCLQVYRRQQRKSRQAWLAGFQTPITYYRRNTIQLEPSKAIAAYDATLSDEITINVGDLVRVHGYYDENWAYGQNDTLGIQGMFPRSCLQASTTTTTNTVQPDYRHSKTPSYHETITPPPTAAIKEEKPLPLSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCV7</accession>
    <name>A0A8H7PCV7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCV7"/>
    <dbReference type="OrthoDB" id="2252306at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034486133" evidence="2">
        <location>
            <begin position="19"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="331" mass="37088" checksum="9C435A693FC89C47" modified="2022-01-19" version="1">MIFNLFIIILCLILSVKAGVGTYADADITGPQTLDNATNIPTGFYSFRNHVTGQWLEFISDGNQVQPSNAQNSTVFNGTLWAVKFHGYKNYSIHHLNGDDSSSGNDKCISTRWDQYIGIDDAAVMWQCELDNITTTPLDFDISPSFSGVYDPTEGLQPLERRSYRERRYVNTFEPIRPDKQQWLFIPQDVGATPSWKNLTFNATTGNNTWHGPHIKPNASANSNYGQNTFYLVSAAHLWNMYPRCIYPLPMNTFNFTANNTVVTTLEDCQIGNETLLWDMVLWEAENFPLGEASSPGPAQNPSKKSAGSTLTIPISTLFCLFIFAYACLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCX2</accession>
    <name>A0A8H7PCX2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome alpha-type subunits domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_008325</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCX2"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000055">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="9">
        <location>
            <begin position="9"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2171599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="257" mass="28385" checksum="3236BB8687548D26" modified="2022-01-19" version="1">MSRGSSAGYDRHLTIFSPEGRLYQVVPLTQLIQSPIEYAFKAISNAGITSMGVRGRDGCAIVTQKKIPDKLLDPDTVTHIFALTPSIGCVVTGMIADARVQVTLARQKAAEFRYKYGYEMPTDMLAKAIANSNQVATQEARFRPLGCSIILIGHDDERGPQLFKCDPAGYYVGYRATAAGAKQQEALNHLEKKLKKEPQLDMNDTVELAITTLSTVLAADFKATEIEVGIVEKDTNRFRKLSVEEIEDSLQRIVDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCZ3</accession>
    <name>A0A8H7PCZ3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF427 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCZ3"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="entry name" value="Domain of unknown function (DUF427)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310:SF9">
        <property type="entry name" value="BLR5716 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310">
        <property type="entry name" value="DUF427 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF427" evidence="1">
        <location>
            <begin position="152"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="256" mass="29371" checksum="7CB1E40601F56C1A" modified="2022-01-19" version="1">MASHHRTPGKRLVSEPETVVYEESPRWIRGYYQNTKVVDSKKAYLVWEGTNHIPFWAFPIKDIQGLEPNNNKDGGREGIRDQWYDLKVGSETISNFAWSIHQNTPGSISGAGDVAIVASQKLDHWLEDDETIYGHPRSPYARIDVRASSRHVRVDIDGVTVAETKNAMFLYENGLPTRYYINTIDVKRIDLFHPVSLNTICPYKGSASYFSAVVNGKNYDNIVWTYLEPFEGLERIKGRWCFYNEKLDIYVDGEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD10</accession>
    <name>A0A8H7PD10_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_008040</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD10"/>
    <dbReference type="OrthoDB" id="660550at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034979759" description="Peptidase A1 domain-containing protein" evidence="12">
        <location>
            <begin position="21"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="13">
        <location>
            <begin position="74"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="14">
        <location>
            <begin position="504"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="404"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="447"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="105"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="326"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2171660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="58665" checksum="C90C78B7573D2623" modified="2022-01-19" version="1">MKVFATLTFACFALAEVVTAAGITLDFKRDLPDASQALAANKQRATHLKTGGAKSFAGTSSRPSYPMFNSIWSYLIDIEVGTPPKPFKVIFDTGSSNTWIPDAACGSACQGAPHSFNPKSSSTWKNDTGNSMDIQYGSGYCTGSLGTDTLTFGKSLAVPNQEIGLANTAASSITSAHVDGIMGMGPDGLSSGFNSAGKVLNTPVTNMVANHLVSKNMFSVYFAPVPSGKYSAMNGQVTFGDLPDSSLYSGSIQWSPKLSSGVTAKYWGIQVSNIKVGSASVVSSFDTIVDTGTTLIILDNSIATKLYKSIKGAKYNDNAAMWEVPCKTLKSLPDITFTINNKPYTLTPEQYTVPEWEGAYWGSTDAGQCLSYITGENMNGLNILGQKFLENYVSVFDTDSKRIGFAPRKGSSASSATTSAQSSGHKTTKKTTKKTTKTVKATTKGKTTTKHKTTAKAKTTVKAKTTTKAKNSSKAKTTKRKTTTKAKTTTKTSKRDTDASVCKKSYIVNKGDTCVKIAHKANVSQAKLQSLNPSINKACTNLRIKQVLCIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD18</accession>
    <name>A0A8H7PD18_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PLC-like phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD18"/>
    <dbReference type="OrthoDB" id="2343482at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034777948" description="PLC-like phosphodiesterase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="49164" checksum="FA9F308B562731FC" modified="2022-01-19" version="1">MVRFLRTCFAVAAGALALTTAQATSVQGKDSSTSQSFSVSDLQVSPHVTPSYEPCNDFPEYCQLPIDWSVWLGAIGSGSSHIDQVLTLDNGSWAQSTDISSYDYLRTQQRQVTSMLDDGIRLLRLDLCARSDEQPYICRSEENATAYITPFKSYLEESFQFMVDHPKQAIILHLEDNPMDTVDIQQIEQVIDEVCVELANRTLGVKHFHSGECPWIYTIDAAEPLPTIGEVIGYDPDMAQWEGDGEDVGVQSKMIITHSQDFIKPYGYKATYMSQPFWTSTYEPIQEFSQLKSRLRKLCKKPIAIEVVGSLSVPPSQCSGDEKCLKTKGIFGESSVYTPSGPGSSAPLSDKGLLLDALFSKQACNMNSMPEQTRLVAVSVNFYEENWTFLKNQQRKWLKENSQKLEKVKSTQESKRYESRETASNKQAPAQTSSLHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD31</accession>
    <name>A0A8H7PD31_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD31"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16992">
        <property type="entry name" value="ENTH_Ent3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF45">
        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="2">
        <location>
            <begin position="36"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="498" mass="53358" checksum="1813855831D6F47B" modified="2022-01-19" version="1">MNSLSEFKIPDFWEVKPSYEPTIEQALIFVYFNRRNVVLNYTEMEAKVHEATNNEPWGASSTLMQEIAQGTFNYQYFNEIMPTLFKRFTEKEAKQWRQIYKALVLLEYLVKNGAERVVDEARSHMATIKILRNFHFIDEKGKDQGINVRNRAKELAELLSDVDRIKVERKKAKHNRNKYTAVSSGSAFEGGGASRYGGFGSESSYSGGGGGGGGGYSGGGGYSGSGSFSAGGYDDEFSDNYGKSKYDDDSPEEDFSSDKRQTASDTNSISSPKVSKQPAKEVNLFDFDEPAAPAAQTTSHAAADDDWGNFSSGGVANDDFDDFQSAAPVTNNDAFSSAPSSAKQPAQATSKSNDLFDLLGDDNFTSAPPLNNAAPLSPPATMNTQSMAPLAPAGQSTTANKPAASGFPAGKSNDLWSQASGLVSLDSLGKGGNQNKPTVGPSMNSMKSNATASEWSSWANASTPANNLGGFSQPMKSATGNNQQQAKSSSNAFDDLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD37</accession>
    <name>A0A8H7PD37_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide-O-fucosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_009136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD37"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36050">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36050:SF1">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034585165" description="Peptide-O-fucosyltransferase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="50215" checksum="2855026264C719E7" modified="2022-01-19" version="1">MKKSSLRYLLVLIPLSLSAITLTALVSRTKASTTFPGLYSSRVQINLTAVSPQYEQPTNVDDTKYLAYLPHSGFANQRTELVNAIILAKHLNRTLLIPPLFLGQVEGWQGEGRLWETLAELTDPKRRTQCRLDDSNEEDQLCAHYKRFGMLRWSWASDLAPLTTEFGVQYLERQDMSLQSLQDSLNIGPYDIYRITDEHPYAWDVRGGNTPASNNPRYIKHFRMNQLEVPHKVLHFYGLFGEGRVAADKAERDQIKNVLVFRNPQVVDVAAKYVQAVGGIDQFTSIHIRTGDGVFRRTLASRIPMAIERLHRVIGDRDSEPNDAAKQNITDENRVEWCINNQASNPRNAMVFVATDAKNPREDLAAVFDEFPCAVTMQDFPTSWLEPLQEASVATQQHIENWLLTFVDAEIAQQAKKYIPSPGSTFSGYIGAIHRQRINYTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDJ1</accession>
    <name>A0A8H7PDJ1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T2</fullName>
            <ecNumber evidence="2">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_001402</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the RNase T2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDJ1"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034921793" description="ribonuclease T2" evidence="6">
        <location>
            <begin position="19"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2171926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="249" mass="26703" checksum="9639CC6DDEE6F7D1" modified="2022-01-19" version="1">MIKSLLVSLALIASSALAAPATLTSKTSCSATAVSCSSSASSNTCCSPKYGLVVLVQQWVPGYGPDDAFTLHGLWPDECNGSYAPSNGCDSSRQWTNIESIVENYGPSTLHSDMLTYWPSDAESNNDFWSHEWDKHGTCVSTYAPTCYGSSYTKYEDVIDYFTKVLELRAQYDLYSALADANITPGGSYSVSDMQDAIQSAFGVTAKIDCSSGTLSDIEINFVVKGTTTYIPQNTSGSTCKGTVDYPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDU0</accession>
    <name>A0A8H7PDU0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_008267</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDU0"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034092788" evidence="4">
        <location>
            <begin position="27"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2171541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="402" mass="46547" checksum="7E51B436889264D9" modified="2022-01-19" version="1">MHVMLFCMAFMLILVSFNLFSNKVASFTSMSSSKSYNNSFALPDHISPDDPVRACFVVLVRNSELNGLLSSMRQLEDTFNRKFNYPYVFLNDDEFSPEFKDLTSAATSAKVEYGKVDAQMWGYPSFINQTMAAETRTQMAAIGLPYGGSESYRHMCRFQSGFFFRHPLLDQYDYYWRVEPDVDFTCQIDYDVFKYMRNNGKKYGFTIAFREFMGTVPTLWDTIRNFKKDHPEVADKLPAKGDSLIDFVTDDNGQTYNGCHFWTNFEVGAFTSAIASLDLWRSNDYLKFFGYLDRSGGFFYERWGDAPVHSIAAALMLRKNEFHFFNDIGYRHTAYQHCPVEPEHRSRCACNPDDNFGKLTQITSDYMKLSVMLPSAFTELLHHVPTDYEPNLSCYRNYVSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDW7</accession>
    <name>A0A8H7PDW7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_001583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDW7"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2172106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="131" mass="14715" checksum="F3C3CE7C4EF105C0" modified="2022-01-19" version="1">MNSPSELSQNQLQDVLIIGGSGNIGSRIALTLLSLNKNGCQRFRVGILSRIQTFQNGAKREVLHNLERHGTTIMYADYTEDQEPLKAMTGSDIRKCTNWCLTDRIDIFHIRDIMSTIRSTMTSKATRSGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PF05</accession>
    <name>A0A8H7PF05_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_000068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PF05"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2172721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="176" mass="20109" checksum="E27F42D900A4B414" modified="2022-01-19" version="1">MQDWKTTITFSIHLSERLHIHESESYTDSPLISEVEQAVDIVRLPTLPAEAPLPTNIPETFELATGNSDQYLWLDAPGAGHRKSPPRQRLLNNAAYVKNLRAWQEQLPNGQQRLVNPLLDWTQVTANAPSIRELRGGWNPKVVIYRSSLIITPTLFLSVFEDFRFKRGRTGIHQIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFC0</accession>
    <name>A0A8H7PFC0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFC0"/>
    <dbReference type="OrthoDB" id="2389377at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2172907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="265" mass="29876" checksum="FAD8BFAF5EDF9775" modified="2022-01-19" version="1">MSVVSTIMQALYLVLLVCAITVLVIQSLEFSLFESRNFHSQVSTDPRTVAIILCFLFSAFSILVITALLCLATRKTFRFSSMERGIGFAMTGLWISLVVVLFLLEPAKVVQASSDGDNQFKIWLALRVFACMTAFLWLIRTLILYSRLVKASLEATSRRPSTTLPSIERPKWQSHPSMSESLNSFAINDKHMNPSTASLRSSRRESQLKYQLPNDTSESQVLKSQQTADGPPDHPVSDIEGGDGQNDKHKHRSFFLNEIHQDREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGL3</accession>
    <name>A0A8H7PGL3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_005015</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGL3"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="30"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2173597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="491" mass="53854" checksum="9B520C62B27F7E22" modified="2022-01-19" version="1">MTESIETLKPTEVILNSVKNKGMRKSVYIAATMAAVGGFVCGYDTGAVSGILVMPTFQASFPEFEDETQFVYLEGLLVAFMLMTAALGAFLSGPICDKIGRKRSIILGSYIFALGILFEIIGFKFGLLLTGRLVAGFGNGLMTNAVPLYHSEIAPPDIRGRLVSLFTLMSTFGQVVGYFVTFGTSYVDNAWGWRGPWLIQLVVCVILGTSVFFLPYSPRWLIDQGREGEGLAVICELQEAPADDPGVKAEYNEIKAELDLEKSMGKRTYTELFSKANRKRTYIAFFIAIATSFTGIDAILYYGPSIFMDAGLNDVSSSIAATGATGIVSLIASFVSLLIIDKLGRKFLFILGSVVMGISMFITGAMFQVYAYIDADSGSVVMTNIYARNAIMAFIFIFMAAFSLTWGVASYVYPAEIFNMRCRAKGLGLTYGLNWAFSILITYVMPLFMATTLSGSYFFFGACCAVMTVVIFFIPETRNRTLESMEEIFHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHM9</accession>
    <name>A0A8H7PHM9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_005280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHM9"/>
    <dbReference type="OrthoDB" id="2291065at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="413"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2173860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="809" mass="93334" checksum="76483185D745BDB7" modified="2022-01-19" version="1">MSGRQSNANRQQSQLPSVFDRLGGDRPRNIPRRGSTGRAGPPGRDGNSARVITVVQPDNQPRRDRMIQQDVRQDTFSKESYHTRTPQDRPPPHTYRSANDIPVNPRPDRRFPRETEERPIQHARRSPDRLPPQRERWPESNRATVVEPAPPPPRQYEDRGPPRHNRSEPYDRRRNDRLGGNQDRRYGDDRPERPYQRRDKRDNRPAAPPSHKTSQPPSHRDENGDSNPRKVHSDGKESVKSNPREVSRENDENDRVSRSETPPREPSRSPSKEAESFEEEELVKDYTEENHAAVSAPLTSIVQKIFDRDEDEGIMQPDWGQDDDDLMDEDDFNVVVDAPEKSKQRDSTPKTDSKPNDQHRSEPTTNKNRNEEKDAANDKKVDKDSKETVAEKSETRDKEAQDDTSDPNIPSKDSLPSPWEKHKSRKGDYYYYNPVTGQNTWKFPKAEEIEEASERESNGDETARKSSEQPATVVQPRSVDDKGRSDVDTSSERNANRDTHRDTHRNTHRDTHRDTHRDTHRDTHAPRASAPVEQSRPAAFDRQEHNRNGGKDQLREREHVVPPPAPKRMRRDIGEAEQRRGDSGGHQDIRHQEVHPRQQDISSRASALPSQEDLFRRRDDFDRRSFRQPPPGRGPPPPRQAEPPHRRPQSPPPIRTMDVPPRRPRMSPPPPLAGDRRPGPPPRRRSSPLPPRTRRLDEPSPADHPRRGREPYNMPPRDVPRSDRFHNRTPDNPNFVPLPVHHKDKAARSPPPPSPLSGANEVVQEQRRPVRQDEGKAVSRRQEVITNSRIERNSRAHGRNQDPSHSTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PII3</accession>
    <name>A0A8H7PII3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_004220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PII3"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="4">
        <location>
            <begin position="107"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2174199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="160" mass="18424" checksum="D3D3F00063ED9931" modified="2022-01-19" version="1">MVQLLSSDNETFTVDKQVAERSILIKNMLEDVGESDAPIPLPNVTAKILKKVIDWCEHHRGDPVSQQEEINDRKRLTEIDEWDQKFMEVDQETLFEIILAANYLDIKPLLDIGCKTVANMIKGKSPEEIRRTFNIVNDFTPEVRQFGIISHCYFLAMLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJJ1</accession>
    <name>A0A8H7PJJ1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_005977</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJJ1"/>
    <dbReference type="OrthoDB" id="369569at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017207">
        <property type="entry name" value="UCP017207_TM-p85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="16"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2174915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="181" mass="19736" checksum="E9D7A0CDA36D25FD" modified="2022-01-19" version="1">MSSPRSKWQLDFASLEPTSRNSNVPDPIGFDKNLAAQGSRESSKLSRAAGSDHNEMTLKARRAWDVAMAPAKSIPMNAIMIYMSGNGVQLFSVMITAMLFWNPLKAILSLNQTFERFEPTGAAKNHPEASLLQAKATFLAFQLVTIGLGVYKINAMGLLPTTTSDWLAFMPPKQVSDTAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKB2</accession>
    <name>A0A8H7PKB2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxisomal membrane protein PEX16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peroxin-16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKB2"/>
    <dbReference type="OrthoDB" id="2021143at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013919">
        <property type="entry name" value="Pex16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08610">
        <property type="entry name" value="Pex16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2175709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="385" mass="43905" checksum="3EB8E6D48164D5FE" modified="2022-01-19" version="1">MELLKKYEDFLISNASQITGIEGTLRSLTYFLPGRFHDAEFASQALFAALNVLGLYHDTILRKAAKSQGKLPSGDNIDSSPFNKYTAHWFKKSSVYKNISLVLSVISYTQVVLEMAVTKKLGKRAKWRLVFGVELLKAMLRLTLLKLTKERMLLNPNHLQRDVDPASLSTPDGYQAQSVEAKTWKGKKTGLVHPQMDAAIELNGNAKPESNGFTPAEAQRKYGDVTEYLMSKVLTPERLRKPEDTVSILNRLGKLGEVLYILRPLIYVLAIFKYGRYSWRPWLISMIVESASQAAITRSFTSPYGSTKSTMTALEKAELSRRFNQMWYNVLRGQFYERYTRPRLEKFCIATQDRFLISIVAGNITGVIRDYQPLWEKVYFYTSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKI2</accession>
    <name>A0A8H7PKI2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_001369</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKI2"/>
    <dbReference type="OrthoDB" id="20886at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2175722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="341" mass="38778" checksum="3A2EF61E37F78420" modified="2022-01-19" version="1">MTAPMEEKDASQYPKPSRGLHVKDENYGSISRQENEPPGLSEGITLTPQSLSPQMSSTHTVSQEPKENMRNGTEARSPSSDTRQEQLAVENTVQESNLSDDQGPSEEKDDMEAAAYEELRLSAFKALQCIEEDFAKLRERYALAMLNDLAIIQKIKYVLDSVFRRLYHERLAELDKEVQAITSGKHPEYATAHSEIESRRRKLLKEASKWRQHRETDIGRQVESSLRLAHVHFLAKRAELRRSIINNITEKRRKLRDEMACSDDLGETLATFIQLMISMLTSSHIREHNAKENKEVVDISLNIGFPIGAKPSGLEEAETESDVRMMHAVSTGDKRSIKYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLH6</accession>
    <name>A0A8H7PLH6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="2 9">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_005427</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine(58) in tRNA + S-adenosyl-L-methionine = N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10365"/>
            <dbReference type="Rhea" id="RHEA-COMP:10366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="2.1.1.220"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2 9"/>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLH6"/>
    <dbReference type="OrthoDB" id="1925287at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000247">
        <property type="entry name" value="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.20:FF:000002">
        <property type="entry name" value="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="12">
        <location>
            <begin position="64"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="259"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2176193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="328" mass="37388" checksum="862F20F2C1130EF8" modified="2022-01-19" version="1">MSLHKYKRYIDEGDLVAVYLGRDSIKPMIVTKDESHVNKFGTFPHNDWIGKEYGSKVVSSRGTFIYLLHPTPELWTLILPHRTQILYIADISFISAYLDLKPGTRMIESGTGSGSFSHSIARTIAPTGHLFSFEFHERRAEIARQEFKDHGLDHLITLNHRDVCRDGFDLSDTVNAVFLDLPAPWEAVASAKKAFKQHRTGKICTFSPCMEQVMRTVTALNEHQFVDITMFECLIRNYEVQPIKKLTVQDAINSIRSMDAKRRDPQANAEAKAKRRRNEFDETDKETDVDDTAEMIVSRTRTEMKGHTSYLTFATFLPVEAVQAPASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PM20</accession>
    <name>A0A8H7PM20_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein TSR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_005464</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TSR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PM20"/>
    <dbReference type="OrthoDB" id="263560at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="113"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2176230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="19636" checksum="015885C7A95D0A23" modified="2022-01-19" version="1">MVHPNQAAFAEGLGYILKSWTALKLAVEQEWGGPDSIEKREWMAETLVEYFGANAKKLDEFDVEDILVQIMSDEFHTDLEDGSAFAVSKHLISLFNQCIHGDHSEVAKLREKFASRSQQPAGQSGNNEGDSDTDGDDDGSEGDDDAMGVEEASTSQEPQGPIIDEDGFELVTKGRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PM54</accession>
    <name>A0A8H7PM54_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_005509</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PM54"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2176275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="391" mass="42807" checksum="CBA783BD83AE7C7B" modified="2022-01-19" version="1">MVNRIIYKSFLFPSRFGYNYSWGVFLNYYNKNVYVGQLATLSWIGSICVSLFFFLGPVNRLVIAKMGYRNMLIVGNIVCPVALILASFAYKIWHVFLTQGVLFGLGASFIWFPCIGASQQWFSERRGLAIGLAMSGSGIGGLVVANIAQAAISNLGYRWALRIIGIMAFVLLLVTTMTVRPLGHIRQTGGQDHIIAWYLFKNPQFVVTFLHGLITTFGYMTPFFLLPAYANSLGLDPWIGTNLSAIMSGINAVARIFTGFMGDKLGRFNSLFICTMLCGLTCLVIWIPAKSEAGVWVFAVLYGFFGGGYVALFPTVQPQVVGLENISPAVGLLYATNFFGYLFGTPIASKILETTSNYTYAAAWAGSTVMAGGLLAGVLRVQRAGWKLVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMC9</accession>
    <name>A0A8H7PMC9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_005574</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMC9"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000016">
        <property type="entry name" value="Transcriptional activator Myb isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="175"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="255"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="255"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="309"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="309"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="361"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="361"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="7">
        <location>
            <begin position="364"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="413"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="418"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2176340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="517" mass="60439" checksum="5D895BE9A93C977D" modified="2022-01-19" version="1">MTRASRRTASRSSSRGEQVEESGANEVRPRSTSGSSAFAAQNIQDFGQFKVRSGSDLQQKRTNSGSHALAETGDTMTPHKERMRVLEALDLNQTMQQEIMKQLSWIDDSIVLNLQHLYEVRAMRWKEQRINRSKSFAQRVSGRPPNFFVDEHNEAPALPKTPYNATAWRAYRYRPWTHKERGKLIEAIRTEARRLMALDYHASGHHHLIWEVEKVSDERLEVYSVDRIDWKRVSKIYVPTRTPMECMIQWTTQEHPKINKTPWSVKENQTLMKLVKKYGQYGNWEKIAIALHTDRTVSQCFSHYQSQANRQQAKKKWTKSEDRVLTQAVKQLGPRNWQQVAHMLGDRTGGQCLQRWTKALDPAIRRSRWSAEEDEVLKNAVEVYGLGNWTKVQQHIPGRTDMQCRERWVNILDPALDHSKLNAEELEKLQDLVKEHGPKWSVLVQYFPGRTDNQLLRAWKTLGQQQQQTDRQVSVLLLLRLSDVTSYRINQPQEKVTRLRETITNLNREPNKCRPNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMV9</accession>
    <name>A0A8H7PMV9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_007611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMV9"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2176957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="226" mass="25491" checksum="6B03566797BE7F82" modified="2022-01-19" version="1">MAPLQVIGSGWGRTGTAAMREALTTLGYDVHHMIVILSNPDSDKQSFIDAWEGKEVDWNKPYDKFNAAVDWPTSTFYKQLIEVYPEAKVIHTTRDAEAWYKSCKNTILPVVSEESAADTPPHVAATKEMIKKVIWQGEMQGKMVDKEAAVQMFRDHDEEVKRTVPSDRLLVFETGKDGWEKLCTFLGKDIPDTPWPHVNSTEDFQNRVDNIKSGKHPEGFTPGPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMY1</accession>
    <name>A0A8H7PMY1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMY1"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858:SF1">
        <property type="entry name" value="LD15494P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="1">
        <location>
            <begin position="57"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="454" mass="49888" checksum="5F47B4DBF1AAE4FE" modified="2022-01-19" version="1">MTTLFDDKAADVIDLSIGAPARDLMPVDMVAAACTAALSSNDKACDSFQVSSDDMSRCIPAAIHSNASCKQYGPEAGDGQYLSELSILLQEEYCHLGLSPIASDSHLCCTSGASQSITNLLTLFSEPTYTSHVFLQSPTYHLVFQMVKDRGYKTDQLVGIPEDADGIDIAWLEGKLRELEIGKNKSVESPYYSAVLYTVPTYSNPSGTILSHERRQKLVQLAHQHDMLVICDDVYDMLYQPSEGKSLPPLVSYDMAYSSEGNGNVISNGTFSKILSPGVRCGWVQARSGLIKRLAKRQGCSSISGLHASGGSPAHFVSKLILETLRTKDLQKHIAKTRDILSERMTDGLITPIDELLLPLGCSYHKPKGGYFLWLKLPQSITSQALEQTILKNRIKVSCGYGYHFAVPSKDHDTYKLEIGSHVRLCFAFYSTSDLKSAVERLHQAIKICLESQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PN55</accession>
    <name>A0A8H7PN55_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PN55"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="890"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="941"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="946"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2176996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1183" mass="132559" checksum="AEAC28DB1704DB51" modified="2022-01-19" version="1">MSVSSPSTPPPQIGVHFNFDTAKEIILCATNSQLLRYTESGLGYNNRIYYCQVKEDKQYVLKVQGRFWTKIKTETEVAGIQLAKKLTHTPVPEILQWESSPERYGHEYLLMSKLPGVSLDQEWGKLEPRQKMDVMDQLAGYVADMQEKIRIGTNIGNFTFDINNGVVLGKTVEASIGPWDTFQEMMVSQLQDKLNALRCQDQYAFLLRGMQHELTDLMRSIDSGDIHLPPAPVKVFTHGDLNERNIMVEKVQVGGDIKLNIVGILDFEWSGMFPCTEEYFASYEFLNSDPYLKNGFYDKLEQLGVGTPRTIPYFNEHAKLIQLRESIAPWWITKDSSQAQQEQCINELRAAIGAVQSMPRFYLLRNRVIISFQVQMKLFADNKSSKLQKKLQRQEQLLYEQEQFRRLAQIDEDARLAKQLQEEENTSRANVSPQDSRPPPLPSRPPKPLAYFPEYLPRHDSDPSPTTPTTQSNLPFGRLRTTSTPPAVDSNTFPPRNPPARVSPTERPSNGRSSPPLYPPTIAPSPPRPSSTQVYPHLTTSPPNPSTSAPPTFPRRDPVMFIIPTSPVNSTPAPPHNSRADHMPVPITTNNTHPTYSSMATTLPSNYHYSSPPYNNYHSPEHPHHQGAPEYSQQHQSMPDYSHQQSMPDHTYQQSTSSYGHQQNAHDYMHQQNAQVTQLHNNTSVSNIVTNAALMNHKFSHPTSRPQLEGQSYKIEKPNDESGKHEDEQGGSRKTSVSPNHEDDSDSDSDGYNDFVVRVGPMMAGTKKKMAKPKPSVALTGKESVEKEHKVATQPIDHAMDLSDPFADTNAIEGDDLISANNTFGSNAEIKSDLLPTMTSATPRPSLAVVSEIPRPESAANFRKMQQRLSALLQGDPEHADVNRSAVTLASVVEKDESPPLESSTKMENEDEEREPDEKVEIVKELTVGVANTPAALHTALHSRSKSTPPEQTLLSTPMQDGRPFHRTTQAPATLRPVVPRTPTARHNRSKSFSDSPTSPANGRRYTIAEPSLYPPTVTPGMVSMTTQSKDVLAGIPQNEFGFYRVDTPKPGSQLLERKALPQLPPNLPQGKSENRHITCKLPKQFTAGHRVWIAIKPSDTGKTLAQRIHVVATFRTMKITGLRTANGRQVPLDNTPVFATWDEIENFQDGELWTFETGGEPENFLIQGGKDWFKQVMNNIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PP35</accession>
    <name>A0A8H7PP35_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteophosphoglycan 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_007628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PP35"/>
    <dbReference type="OrthoDB" id="2020419at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2176974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="52280" checksum="5F676D5C10E5BF0F" modified="2022-01-19" version="1">MLSIRRSQTLIAAAAISLFLLTYLSWNDRSYTDYVSSHTTSAHIDEETIREIDERYCGGPCRFLLPVFIVEQESKAQMHFRQLAFTAGLVNRTIVLPNVGNSRLGACNEHEFGFYYSHEWLDNNRDHFKYITLKHFQDWLEERGAVGTKPTSQDVILQLEPTRQHFSDNQVNCWQSWLDMQNLPVRHLDLADRESSSGVEIENKIVSFLKGPSEDELRDNVAVGRNLEVLSVFYDRRFPFIQNPASQTALTYSNQLTNLARDMADSISPFLAIHWRTERIEPASNLEKCARTLVQKIQNTSPKSIPNIFLLTDYPHLLNTPLAATHNGTSGSFRPSQISESHHAAMRYLYEHAKVTLTTFADPKEVQGLPANWTLLHMPPLKTIDGQLVQGDKGVLGIVDKMMAMRGHWFLAGQPGVCGRSSSFTNRIVAEREYLLEEENAGFANIVDYFDLPEQSDATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPI3</accession>
    <name>A0A8H7PPI3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPI3"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003486">
        <property type="entry name" value="Major sperm protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="273" mass="29779" checksum="DAC561330EFCECD2" modified="2022-01-19" version="1">MSANSSDSQREATSTPTQAASTPSAPAKAVQVKLVLLGEAAVGKSSLVIRFVNRDFQENREPTIGAAFLTQKCNVDDRSIKFEIWDTAGQERFHSLAPMYYRNAQAAVVVYDVTKAVRISICHCLLQSSHLRYTFTNRDEQASLDKAKSWVKELQRQANPNIVIALVGNKLDLVQQAEEEDEDAEEGASTVRQVPQEEAAAYAQESGLLFFETSARTGDGVDQVFSDIAKSIPLEHILASSRGSRQSNNPRIDLMREGANGLRAPGEGSSCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPR0</accession>
    <name>A0A8H7PPR0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_003068</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPR0"/>
    <dbReference type="OrthoDB" id="25131at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039328">
        <property type="entry name" value="WDR89"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="297"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2177821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="39443" checksum="F489014169E64C87" modified="2022-01-19" version="1">MAQFQLSQANDLLVPMHLYKSTHFALDNSYIYDVTANSSHVIVSASNNQIKLYNPETLSIANTLVYHNEKITKIKPVGEHELFSASLDGQIARWDLRTNNVVQQFKAAPSSVSAFDINCNGTVIAAGSELEAHDAKLMFLDTRTSQMLASFDESHSDDITEINYHPTIPHQLISASTDGLICQFDTSTYDEEENIIAVINSGSSVNKAGYFGPSAEYIYCLTHIETLSLHNLEGDVVSNFGDIRQATQPGQLQVDYAVDCRYEPVAQRLYMLTGSNSGDINVMHVNIGQLQLCQSLKGGHTEVIRSIHWNPQDNVMFSGGEDAKLCTWSNAPPPADATGNGVVRGLPSRMQTKRHSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPV2</accession>
    <name>A0A8H7PPV2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPV2"/>
    <dbReference type="OrthoDB" id="1684416at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="519" mass="58951" checksum="DAFFD79C83A46A98" modified="2022-01-19" version="1">MLGTDSPTRLLPHSEYNVENTAPRTTDSYSQSFYSPISPLDKLGASKRLSSMKRLSSPNLWRIRDSQPLQTVQNASFTNDNDENDKNDSIRPEHLPHLESPLAKDDKLYVSKEIDHHEIDEAPKLLDNKHTVNNAEGRVVNSKPKAAKKPMPSYMRFTEAYKRSKGLIADEEEERELHHYRSADNFNKRTGHNTKALLGPKSAAGISVRVLKNKKHTVPQPFHFHSSLRAHVVQESSDNQKDGDEPFVSLALRIKQFEENIAGRGYEHGVKDKELKHDSEIITTRHIVPRSPRLLTKIRHSQGHHHSHEAHDNTEKVSQKPAGRAGSSGLTADRDRKLARSAQYIATKPPILHTALRASHATSRADAEMGKSVDTQRKPNASVLKRKRQQDASQDEHHKRQRRDATTKKQPAAFVPTVPQPFSFQTDLRGQHYQDQFMEKLEMWRQRDNGSHDIHAKPAPHYPPPIAIKRSVKPLTAAQEVVLHSEIRALERKTTEDDKKLKAKLAALEHESSNRSRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPW5</accession>
    <name>A0A8H7PPW5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperone HscB C-terminal oligomerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HscB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPW5"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="entry name" value="HscB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021:SF15">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="HSC20 (HSCB), C-terminal oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Co-chaperone HscB C-terminal oligomerisation" evidence="3">
        <location>
            <begin position="165"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2178092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="249" mass="28823" checksum="26747B3AD5607A6C" modified="2022-01-19" version="1">MTRVLTRPRTILPQRSLTTPLAVQVERIRYFSTNNSAAEEHKVCWKCDHIVPQVDMHCSNDDCGAIQKVPKDINFFETLQAGLGENASEPIYDVDVKKLRLIFLRKQQQVHPDSYAQKSTEEYQLAQNQSSFLNKAYNTLKEPLARAQYMLALNGIEVSESESLEDPELLMEVMEVREQMEDCETEEDIEKLRLDNEEKIEHTASQLTKAFKSKDLEEAKALAVQLQYWDNIRRAIVDWAPGKRIELQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQ06</accession>
    <name>A0A8H7PQ06_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_003067</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQ06"/>
    <dbReference type="OrthoDB" id="6287070at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF722">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="112"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2177820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="529" mass="60727" checksum="FFA4B1562F6E1B82" modified="2022-01-19" version="1">MADFRFGSYDKDTVDGPKKEKKRHILRKLFRVKKRSVLTPPIALTDEQNQKISKLSNHIQRNIGVEPDPSSCQRLLEIHAWDLKEAVQELQDFQDADDGILVTPKPLKINMLGSENDQLTSCYIDALLFSMYATTTVFDPLLVSDIENDDFDKRRLQTALRLFVNRMREGYLIRTDQVRRLREALVATGWEGVTQWGNWAQEDTSEFFLHLTNIFGLPFLPFHVRLYHGANKDTDDDRVMTERTLALPIPTDSNAPIALQEILVDMMYSNMVTGIKRSVLYDEPDEMTPSTPSSTHKAPIHLENASRQVSVAAWQVLELLPFYSGTNEQGERIPVSNYPDGSLILPMVLKRYTCDMYANYKKIQREVVVPQEINFERFLNQNMVNDNVCDKCGQSISYVMRLRSAVCHRGDSPFAGHYIAYACVQDSENDDEEVWIKFDDMNVTQRVKRLKSTKKDKKAVFQDLASSAYMLFYELDRVCNSCQKNGHRVEDESSNASEESLLDNHQLKDKINALEVKASDGRTYSCNLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQ51</accession>
    <name>A0A8H7PQ51_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_003410</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQ51"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03338">
        <property type="entry name" value="TCP1_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000010">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02342">
        <property type="entry name" value="chap_CCT_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2178157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="534" mass="57820" checksum="04B8981FE045456A" modified="2022-01-19" version="1">MAEVKSASAVKPKSFNDKDKPTEVRISNIVAAKAVGDAVRTSLGPRGMDKMIQTSNGEVVITNDGATILKHMSVLHPTARMVCTLVDLSAAQDIEAGDGTTSVVVLCSSLLAAAEKMLNKGIHPTTIAESFQRAAAKAVEFLTEMSTKLDLADRESLLRAASTSLNSKIVSQYSTLLAPIAVDAVMQVIDPATASNVDLKDIRVVKKVGGTIDDTELVNGLILTQNVVKTAGGPTRMEKAKIGLIQFQLSPPKPDMENQIVVNDYRQMDKILKEERQYLLNLCKKVKKSGCNVLLIQKSILRDAVNDLSLHFLSKLKIMVVKDIERDEIEFISKSLGCKPVADVESFTEDKLGYAELVEEAESSGSRIVKVTGMKNSGKTVSILCRGANSLVLEESHRSLHDALCVVRCLVKKKALIAGGGAPEIEVSQRLMEYAKTLKGMEQYCFQAFAEALEIIPTTLAENAGLNPISIVTELRNKHARGEKTAGINVKKGSVTNILDERVIQPLLVSTSAIELAAETVKMILKIDDLVQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQC4</accession>
    <name>A0A8H7PQC4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008003</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQC4"/>
    <dbReference type="OrthoDB" id="192733at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2177346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="516" mass="57169" checksum="B99524F715BCF138" modified="2022-01-19" version="1">MANPNNERVVVAEKDIEEKRISFEERSSADSDEVHDYDTHPALRREIWGWYAYSWAVDGWSAASSSVFMPLVISTMAYTGGRNTADPTKPCNLVQPCVVKLGTSDVTPSSYTLYVTAIAVLIQAIIYIQLGAIADHSGAISIILWMALISDPSAYWGAGLLFVMGNVFYGSSYVFYASYIPKLARNTPHVQEETDPIAKAKKLTLQTTNLSLNAYAAGYSGATVQMGLSIGILYALNSTFKGMLVGLAIGGVWWGVFNTIPHYFVKPRRGPPLPQGENYLTYPWKRLGRTLRRVSYLSQLFQYLLMWLFLSDGIFTILKVSVLFAQTVVHASSLTILTGSLLTMAVGGPSVMLWKWVERRFNVKPKSMLMFLCLMSCFIPAYVLIGFSPNVVGGLKHPVEYYPLCFWFGFVVPAALAYARSTFAEIIPIGRENEMYSLFLITQGGGGWIGPLVTGIISDKTGNMRYCDIFVLVCIVVPVIWLYFIDIDKAKEQALTAAKYEAKELGLNHTTDDSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PR44</accession>
    <name>A0A8H7PR44_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSm2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_003498</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PR44"/>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000009">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016394">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2178245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="104" mass="11729" checksum="85385E35720B1944" modified="2022-01-19" version="1">MLFYSFFKTLVDQTVTIELKNDLAITGTLVSVDQFLNIKLDNIKVVDEARYPHMITVKNCFIRGSVVRYVQLPSQAVDTALLQDAARREAAQPSTVQQANVRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRD8</accession>
    <name>A0A8H7PRD8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_003367</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRD8"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005352">
        <property type="entry name" value="Erg28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2178114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="29412" checksum="B9EAA73313F41E0B" modified="2022-01-19" version="1">MEYFTAQAAEIFSTLPEGNLPRWLLFTSALGIFNSVQNFFTDKLTKQVYANKPNEGNTGLPSALTPLSGRLFATWTWSVSMIRIYAAFHLNNKIMYDLGIWSYVIALTHFVGELVVFGGCKVNVPFMSPMIVAGESKETVAVKAHELRNKNKAELSKQLDELKQELASLRVQKITGGARLQKIGATRKAIACVLTVINQTQRDQLRLFYKSKKYTPLDLRTKKTRAIRRRLTKNESNKKTVRQQKKLAHFPQRKFAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRG5</accession>
    <name>A0A8H7PRG5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar protein sorting-associated protein 52</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_001964</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRG5"/>
    <dbReference type="OrthoDB" id="19482at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20655">
        <property type="entry name" value="Vps52_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04129">
        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="7">
        <location>
            <begin position="124"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="8">
        <location>
            <begin position="313"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2179114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="761" mass="87248" checksum="8C0E58718E733AAA" modified="2022-01-19" version="1">MSTDDAELNNPGDPQIENGEEGIEKLNSKSDFKTSTLQLLAQLLGGNAEDENVDEGEQFVRPESDFEDGLDFYQISFDEVDDRISAFQEDEFVKDALEKGMDLRQYARQVESEMYEMQHEHENDYARNVQSFIDLHGQFEASDEILGNMEDMLNVFQTDLGNISREIKSLQERSTDINIKLKNRKLVEGRLGNILDNLVVAPHVIKKITESDVDDVWLQYLLELNKKMQFVKANQSKPIRALQDIGPELEKLRLKAISTIRDFFVSKIITLRIPNTNIQILQQSVFLKYKALYHFVTGRHHEAAAEIRQTYINTMRWYFYNHFDRYHKGLVKLQSVIADKTDLIGAEENVKKGGLFGSGKFSINKTNVFALGNRIETLRAHDAGVILVHIAEDEGVKYPFEQLFRSFNLTLIDNASSEYLFISEFFANNQANNEASKLIFQHIFTLTEDVGLTFTKSYIEQSYDAVGILLCIRINTQLMMELQRRRVPTMDNYLNATNMLLWPRYQHIMDMHVDSIKKMANTKSILSAVKDIHPHYVTRRYAEFATSILILNDGYDDSNVTGSLQRLRNEFEGLLARMSNELPDTIKRIAFLINNYDVIVSVMQESPNRAVSAELEHVEQILSLQKSAFVEEQLKPFFGDIIDCVNSVEQNKIKPMEFSSTQLEKISTHFTQTWRQSLNAINTSIIQYFSNFKNGTTILHATLGQVIVYYTKFIDLLEKRYTDRKQGAGTANGSLGIAGWKVQPVGVQTVMVAVKSFRSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSD2</accession>
    <name>A0A8H7PSD2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_001884</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08284">
        <property type="entry name" value="FDH_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22705">
        <property type="entry name" value="FHA_KIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01233">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000021">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000047">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049780">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Kinesin motor" evidence="17">
        <location>
            <begin position="340"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="16">
        <location>
            <begin position="857"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="15">
        <location>
            <begin position="1836"/>
            <end position="1935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="942"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1023"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1447"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1798"/>
            <end position="1819"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="773"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1070"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="945"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1039"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1459"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="435"/>
            <end position="442"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2179035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1940" mass="217231" checksum="ADA4D37D96BA0B56" modified="2022-01-19" version="1">MLAVTFQKPFEVAVSRIEKPTIKESTDAIVKVSLAGLCGSDLHPYRGAEKGLDPMTVMGHEFVGHIVEIGDAVKGLKVGDRVGSGFTTCCGECWYCTRGLSCRCDQGQLYGWKSQGKGIDGAQAEYVRVPLASGSLLKLPDQVGDEEAILLGDILSTGFFCAQNGFSALTEMDASEAVAVVIGCGPVGMLACIGAKEHGAKQVFVVDSVKERLEVAAERFGAIPLNLADDVEATVKEATGGRGADIVLEVVGQPSALSLAYAVMRPGGVLSSVGVHTAPTFPFSPGDGYDKNLTYRSGRCPSRAMMDKLLPMLMAKKYPVTSIISHRASITEASIMSGGNIKVVVRCRPLNSREQARGATSLVRMTGNQTILTKPPESRSAKDEEIKAFTFDKSYWSADKNDPEYADQATVYNDLGEDLLDHAFDGYNCCIFAYGQTGSGKSYSMMGYGEDKGIIPRTCSEMFNRITRQTTDNLTYRIEVSYIEIYNEKVRDLLNPKNKGNLKVREHPSLGPYVEDLSRLVVNSFADIEHLMDEGNKARTVAATNMNETSSRSHAVFTLLLTQKRLDELTKLETEKVARISLVDLAGSERANSTGATGQRLKEGANINRSLTTLGKVIAGLAEQSSLEPAKKGKKQKEVFIPYRDSVLTWLLKDSLGGNSKTAMIAAISPASDNYEETLSTLRYADQAKKIKNKAVVNEDPNARLIRELKEELDLLRDKLMVYAPEELEQMAASSAHLKGSSGPMSPNTARQALLKQEIVIKDQSGVERKMTREEVVEQLQSSEKLLNELNETWEEKLKKTEQIQVEREKALEELGIAVEKNNVGVYTPKKMPHLVNLNEDPLMSECLMYQIKLGSTRVGRQDSEVPADIRLSGPNIFDNHCQFENINGIVTLHPNEKSMTMVNGMRISDPRRLRSGYRIILGDYHVFRFNHPEEVRRERDLQKTAVTRRSGTPSDFDDERPDSPTNFSENASIVGSEVVDWNFAKREAVLNYYSAESNFGGMKDEELEKLFDDITKIRNLRKTRSESRAGDFEDDTSSRNSYQNGSSSTPVTTLDDGLESVDTDNTLVQAELEERLKMAKEQLQQQLDEQKKEYEAKINRMSLQVSPTGSTMMNGMAFGPLSASMEFYTADQLSAVNKAIRHWKKQRLVIMAETLLTNAIMLKEANIISRELEKDVIYQFTVIEGDNVSNPSSSLETTSALHQYNNDGDANLLSSKTPCVGILVLDSKHQAFYTWSLEKLRMQLHQMRNLYNFADKPQYRKHFNWEDPFYEIPSPKYSLIGRAIAPTRNLVYQQPFKTKANVYCRFTGECKGSLAVSINPIARSGITTSETGENWLRIGEELTFQVQIMEVDGIFESEYSQVHVQFKLSSFGSISPHSVAEKVFCTEPVSDFAASTLQYDYSQTIAITVDEKVLERMLNEPLVFEVFGVAQPRTLNHLELWSASREKPRVGEQPNGLSPQSTSAQSSPSLNGNGTVERRSEEELLAAESHDVLAWVQVCELAPDGNYNPTQLLSQSSVDPGVFLLHQGLQRRIYLTLSHTSGRQFPWTRVLKVTIGKVRLLDAKGRIVESPAHEDIPLRLLPQQKIIYLRDGTSTLSIQCIWDSSLHDSLFLNRTTAMNSRILLHLKWEVEATKCIQPVKFGMDIAVQIQGRDSSNPSKLRNLLASHKMLKKCSGIFLVKLRPPMTRKVTELWRLNTASKPLRAEECLGTWQPRGVSLVHDYNNMKKLLWRKNQVALTRQILNLNQITAVDDNEITATSLKVSTANDRQWSSKQIELLKKVLDIWRTKPYRCKEMIISQDPPNAEDSTASEPRKKTARSDLKLTAEVKQVTQSDSISKKGYLMYQENAVEDKWAKKWFVIRRPYIYIYANHSETDEHGVINLAAVRIDHQKHIEELLQRSNVFALYTNNNAYLMQAANRSDMIDWISKLDQFYPVDKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSK7</accession>
    <name>A0A8H7PSK7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003542</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSK7"/>
    <dbReference type="OrthoDB" id="443772at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2179759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="288" mass="32809" checksum="5E9937F5935DE772" modified="2022-01-19" version="1">MSAVEDKHAEEIINMEEEKNISQDPISLEELDASDIDDEDGDLILEQKVTINNEVAMKRITEEFKLKDLPWIEIMSVTSSEPIELEDVHDDLKRELAFYQQALEAAKIGREKVKAAGVPFSRPDDFFAEMVKSDEHMEKIRQRLLDETAAVKASEDAKRQRELKKFGKKVQVEKLQERQKKKSEDMEKIKMLKRKRKGAEDFSTDDFDIELDGGNDDKSNKKGKRGLSNRDKKNSKYGFGGKKRYAKSNTAESSADVGGFNPQKNKAPFKGQAKRPGKAKRAANRGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSZ5</accession>
    <name>A0A8H7PSZ5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_003771</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0507 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSZ5"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097422">
        <property type="term" value="C:tubular endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051248">
        <property type="entry name" value="UPF0507/Ank_repeat_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="4">
        <location>
            <begin position="230"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="764"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2179984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1143" mass="128521" checksum="1BB74A318ED53014" modified="2022-01-19" version="1" fragment="single">MNAKRFKTVASHVVRLATGNSSPSVQHAHHYSLPTPVASTSMLSRITSPRLERIGSLNFGGSGSDSGDQRRRVMSYDGEKRLLSSTSIANLEKKGITYTTLNHKSVIINDNKPLAEKTQKYRAPHNINTFRGILEAYPAINSSIMSNLEHDIQAFCDKAIEAKDLSDMHNDMKELLQKEFQLLESIDHTLIQKIMDSTRMTSEALYQIFESYIMERTYDIVFFKITSFQQNLDANLSAALHGMANLDLTQVGLPNISGMAKRLAAGLEVFREIGSFRTPKEKLDCLLSAISKLTSSSVAKDSESITSAKSSEETLSMNSDVLIPLLIIAIIQSRVSNLIANLTYMKEYAFEHNVTTGEYGYALSTLEGVIQYLVESEQQLGTISAKNEQFWSYLRDGNYEHVKDVYDEENEEYLNQSIQSLPVIDKDGSMDETETTVQHNTPIAFHQHAIEQHATGPLVEFFDEKEASESVPMRPRTGSIRSLSSGPRSISVMQTRDAQANNALLLACMSDNAKLVEFLLERQNGCGPRDLNNMHRTPLMIAAMSGNIEVVRLLLKDKYVQETIDREDIDGNTALLLACAYAGSEASGKVVKELIDNGSARLRVSNHQGNNPLHVAAIGGRVHHKEILLLLCKMMSKDLLNGQNAEGSTVFHLCKEPDVCYKLIHDRGVHATIADKHGRTPLMSWCLKGDKNMVQFFLEEGSSRLDQIDIHGQSVLHLACSSEKLLSLPSTPEFNDEVMDNVLDIVRMLLAKTTSQLHQRDWIDGNTPLHISAMKSGGYALVKLLLDNNANLDIYNNKGQRPVYVAKDQRIIDLLDDTALFRKPIGKDFDRQCAITRAEIGRDAKVTYIIKCGTLDDRHTVATVRRSFDDFRFVRQQILFELPETFIPTLTDILNPESFNLHPPPIVFLDRATQALNAFLGCLFENHTLKIHELVWEFVMVPDLQRDVIRRRSSAKRDLLIESINDEYSSSLENLESEKQFFLFTKNAMQPLHTALARVAFCSKRIQSCYKDVAVEITHLAQELGRKQAFEFSTKWSSVAFLRGISNPSIFYEVDMVRMMDFAKVIQSSAVWAEGALIGIQRPLNLLTTIEESIDEMEKQKAALQRAVSWNDVFSTADQRKKITDTKDQVLELQFKVTKLACQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PT55</accession>
    <name>A0A8H7PT55_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Choline/ethanolamine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PT55"/>
    <dbReference type="OrthoDB" id="3649325at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF93">
        <property type="entry name" value="RE24176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="43498" checksum="D712D3B767CC58A4" modified="2022-01-19" version="1">MATLTPVQVTLSEDKIPTKKNVRDIIGTCLTEEWPSVDPETLTMSYHASFANSYCTVERPKPATDIPTETLKVFIKFHNDNGGCLEIFKPLAPTRHEEALFCYEYGQTGLGAKIYGFFKTQDGTLGRVEEFLDARNMEPEDVENPVIRADVAKGLAGFHVLKPSLGKKTVESYYEAIIKGLTHYHKMDKLKILGKEGGVSIDKLVDYDYGMRLRNVVNKLNSIGGKTGWCIHDIQFMNVMVKNDPKEDESKIILIDFEFVMHNYRAFDIGGHFMQKMFKWFDEESRIAGCRKYTEEEKRHFCDEYARQWNKLTGDSDTADQVFLESEYGYLLAITFDIHNMLCFMDVEGDKDPLNLLGLNKLYDEFVDQYAKLKLEDPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTI0</accession>
    <name>A0A8H7PTI0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTI0"/>
    <dbReference type="OrthoDB" id="2401996at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="504" mass="55720" checksum="CE4D9B4E6EC5B6F3" modified="2022-01-19" version="1">MQDISDRRESFSTFRSKQETTSPTSGDTAVSQLLGKLEEAGQTIANLRSILTFKTAELNELVGQLEITNQAIENVETTTVNIETMLTEMGLSSDTFENHTRESMLLDAQASLDHALKFANTLYTTEQDHSGTKLTRRRSMASSSSGGLHSDNGERRDRTSANYSVSKIRYKPDAKPILRKLHELIRQLELDSAKFFQDIGSTDDLQKLQKAYVNLEIAKTIALAAKTNFKRRTIILRRARRRDAMEEIDLLGIKIREAVAIWQEHTMYQPLKVDGKDILDILDREDDLIAKNVLCTTQLSLPVYKRMSIDISARNSPTPSTSGSVRRLKSTSSTGSNGSAPSTPTKLTTAIPQLDVPDNSSLSLHHIPPQRFATISGGTKTKTFHRHSTGNTVRPVAVKPVTSSASTMLPRAPLVIKPSVNNNKKEGPDGRPLAVISNNATNTIATVENDSRKESKLQKPSYMGPGSTMRLRDIIMPAVTLRSPPHVAVQQDFGQMEAIPSRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUL8</accession>
    <name>A0A8H7PUL8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_003951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUL8"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2180163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="75" mass="8201" checksum="66E9CA1BD00C31C7" modified="2022-01-19" version="1">MSNSIAGSVDKPAMATEILPKRSSYGSTLAKISTHTSICVFELQAVMKITCTRRPRPYNPKPLPIAAPEVPRLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUN9</accession>
    <name>A0A8H7PUN9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Translocon Sec61/SecY plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_003592</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUN9"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="12">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2179809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="477" mass="52511" checksum="C2A6E6D969C3EFB2" modified="2022-01-19" version="1">MGFRILHLVRPFMSMLPEIATPDRKVPFNQKLLWTAVTLFIYLVMSQVPLYGIMSSDSSDPLYWMRVILASNRGTLMELGITPIVTSGMIMQLLSGANIIEVDYSLKEDRALFSGAQKLFAMIIAFGHATVSVLTGLYGSPKEIGAGVCLLLIIQLVVASLITMLLDELLQKGYGLGSGINLFIATNICETIFWKALSPTTVNTGRGDEFEGALIALFHLLATRKDKTRALKEAFYRGNLPNVMSLLSTALVFAIVIYLQGFRVELPVKSNRMRGQRGTYPIKLFYTSNMPIMLQSTMTSNIFMISQMLYNRFPENLLVKILGVWKPYEGSSQLFATNGIAYYLSAPHSLTDALLDPFHTVIYVTIMLTGCALLSKTWIEVSGSSPRDVAKQLKDQQMTIAGYRDTSMYKELKRVIPVAASFGGACLGAVSVLADMLGAIGSGTGILLCVTIIFQYFEMFVKEQAEAGGMEGMLMGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PV93</accession>
    <name>A0A8H7PV93_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Maintenance of telomere capping protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PV93"/>
    <dbReference type="OrthoDB" id="5594977at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018814">
        <property type="entry name" value="DUF5427"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10310">
        <property type="entry name" value="DUF5427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="40639" checksum="C511B044552B097C" modified="2022-01-19" version="1">MSNQEDLPNSSLTEAEQFLKSLDLPNDEAEEGEAVTAAESGNAQTANASDIMSFLDEIANTTNDYEAKEPTVSQNEENAASDSWIKWGTSFWNQANEAVKTTTDHLSQVAQNPETTAQLQNHVKGWQAFISGDNVTKLGQSLRTLTTETLTTILDNVAPPISEHEVVQIWISHDIAGYVGLEPLVFQAFSKMMEQTDGGDVVIRKGRSTGQRAGEYGAWDMNFCDDITQATKLCKANIEYLNKTHTRSPEIQTAYDPASGAHPIKICPIYLAIQAVQHSTVFNVPHLQFVVLLSDPKHQLNFESYSQNIPMSWLQIPEQDNFWVQQKLEDCLEMCVSTIAQDYVQTRMHEAIQAINSAAAQQKVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWI1</accession>
    <name>A0A8H7PWI1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_008959</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWI1"/>
    <dbReference type="OrthoDB" id="2573941at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12411">
        <property type="entry name" value="RRM_ist3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045844">
        <property type="entry name" value="RRM_Ist3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="36"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="204"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2181376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="303" mass="35615" checksum="24F7D6055D8FE75B" modified="2022-01-19" version="1">MANYSVVKEIQRINERESERGYSESGSWHAQYKDSSYIFAGGLPYELSEGDVICIFSQYGEILNLDMPRDKQTGKARGFVFLQYEDQRSTVLAVDNLNGAKVLGRVLRVDHAQRPKPKKDEDGNLPDEPSMNAAPPLLDAGSSDDDSGDDGIDEEDPMAAYLRKKEKKRKRKEEKSKKKSKKRSKDKREHSAHDDVLGAAPDKQNAEEIPKVDLGRDQPADRSRYTSPDHDRYRQRQDDSRDGERHSRRRDSPDRYERRRDDRSSSRDRYRRRRDDRSDSRDRYRRRRHSRSRSPRRRYDDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXC3</accession>
    <name>A0A8H7PXC3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_006938</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXC3"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000002">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="13">
        <location>
            <begin position="77"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="14">
        <location>
            <begin position="276"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2182012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="479" mass="53154" checksum="1D25704C8705559A" modified="2022-01-19" version="1">MREVISVHVGKLLCQMTSINFFSRLVLSGTELFAGQAGVQIGNACWELFLSSQYCLEHGINPDGHLPEGESTGDNSFDTFFSETSSGKHVPRTVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKELVDVVLDRIRRLADNCTGLQGFLVFHSFGGGTGSGFGALLLERLSVDYGKKSKLEFSVYPAPQVSTAIVEPYNSILTTHTTLEHSDVAFMVDNEAIYDICRRNLDIERPTYSNLNRLIAQVVSSITASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVTYAPIISAAKAGHENMSVSEITNSCFEPNNQMVKCDPRHGKYMACCLLYRGDVVPKDTNAAVAAIKTKRTIQFVDWCPTGFKIGINYQAPTVVPNGDVAKVSRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGSDSMGYSDVDDAEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXJ8</accession>
    <name>A0A8H7PXJ8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_006886</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXJ8"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000720">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="58"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="212"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="338"/>
            <end position="341"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2181961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="376" mass="42302" checksum="B5087F1B5A924297" modified="2022-01-19" version="1">MPAGNKLTSKSASIATLSAPDEREAKRISNAIDRRLAAERAALAKDRTAKLLILGAGESGKTTVLKQIKIIHGDGFTSERVDYRRIIRLNALTAIRELCIAMVQHRVALAFSINQEHLDYLLSLDGTVESTYMNGKKVNNLIRKRQSTDDISADTIFDQAASSIKAVWSDPAAQEVFQRGLAKSMQDSSAMFLDEIDRLAAPRYTPTDADILRARVRTFGVTEHEFKIDQVTYKHINKLNVEYLMWEVRGHKDKAGCKCIYIFGKCGVGAQDRFLSTLVKAPYFDDCSAIIFVAAISSFDQYLREDPSVNRLYDALQLFETICNHRLLRSTSVVLFLNKIDVLQRKLASGTRLSHYFRDYTGMSLFWKACDSIVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXY4</accession>
    <name>A0A8H7PXY4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXY4"/>
    <dbReference type="OrthoDB" id="434647at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF117">
        <property type="entry name" value="LP05237P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2181960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="305" mass="34104" checksum="D26114F8C808A817" modified="2022-01-19" version="1">MLPTFLYFILKTVLLQLYPAYISYKAIKSSTNLQQLAPLLMYWIVTATFLVAEYVCDILLFWFPFYNDIKALLVIWFILPQTQGSVIIYQQVIQPFLTQHESRIDRALLDVQKQARRTGLEYGKRGVAILNNLLGELVNKLRAMILGQEAPPATSAATAQPQASGLAAKLPSWDMTSITPFAIFSSLIRDPNSQTKDEPFFIHPSSLGMPPKDQTELRSQRDHLEKMMKDLDALEPTLLERTESFDSIASYSSAKKVDTPGDSSAAGWASYLGGWWPARPVATSDSQSTDDVTKSKDDVTKSKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYE2</accession>
    <name>A0A8H7PYE2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_006936</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5330228at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059033">
        <property type="entry name" value="C144_05_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26021">
        <property type="entry name" value="Ferritin_C144_05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="284"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="1055"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="1182"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="614"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="894"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2182010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1383" mass="157664" checksum="36CCA99E1A9E5E67" modified="2022-01-19" version="1" fragment="single">SQPVSANGHSTLGHKRSPGDEQNHEMKRIKLESTNGASMPVNGRTESVILKFEMAFDLNNFAYDSIEVQSIPMEPESYDFQFASRNSLQYRWAGMSVNWQQELLLEYEVAVPRKSLGHKGPEAFWALANGCKQGYIAPTILSMCATNSAAIAVKIQAEIQPACPSNLLFSLLQYAFQPPPAPLHYTIEQFYQHLQPLISHDAATAYISPELCPRLLPFQSQNVQWMLSREGHDVSENGDIVPISQDPDNKEAYIWEKVQVEGQEFFINRASEQVSIGVNDSLRYDRTFINTGGILSDEMGLGKTVSMLALILLHRRKANKFEAPNGLIASGATLIITPSTISHQWEAEIKLHAPTLTYTYYQGVKDRKEKTTTPEKLANYDIVLTNYENQLTDALSCSAPKYPPRRSPLIQVHWWRCLLDEAQMVESTVAATAEMARIIPRQYSWAVTGTPMSAGYNDLYGLFLFLGIIPSCSSPAAFTSLYRNPDLFYQFLDLTARTMRRNAKVNVQDQVVIPIQRRKVVHISFSQFEQHYYDDLWAQCRRSINLDWLDSIGWGELEGLTTAQSNQVNQMKTELRTWLLTLRQTCVHPGVGIRNKRHLGSTIHTLSEVLDVMIGQAREKIKEAESNYSSTRLRHAGMHEVLEDWDIALKIYLEGIKYSEKRVEEARNEVEEARKNSLEPVEAKGSSKAATDRLKNVELEKKQNALSVARNRLSNSLLLLHRFFFYAAGMYHELKDEENETKLYDTAEEIRRELLQHSQNKFKSITEDLDTSFKTILSDKALEFMLSKGSGGLLSWQILEDADAVAEKLDAQMEIIIDWRQKIYQYLTLSLENEEEAKGTESDEYETSLIVQETGMIYLDTYQTMLKDRDFYLSGSWNALYLNETSKPEREIDENARTEELDALEKALKELRAKLAAKSSSENNMRVLQNTLRDISQRSYINAQEFTIAGQVIQHLRKETERQKAMLEQLENEAKKFSQLYNARIEYYRALQHISDQVKAWESKDPKGEIDNLKERENAYNREIAAQSARCRYLMNLKKEETAEDVAAQPEFDNCLICSSAFNRGIITYCGHMFCEDCAGQWFESSSRCPTCNATVERRQWWTVALNKPEDPVTAVKQIEYSGDAEELLPLSTLTDILEIPIAGGLGRLNLQYECPHCMYRKNLGLIKHASLIGAKLDTLLKHIQYMIENDNEAKCVVFSQWRTVLDIVAGGLRRNNIGYVEFGKAKNQQQSVLQFRSDPDIHVILLNARTQSSGLTLVAAQTVFMVEPVFNEALEQQAISRVDRIGQTKETTVFWYIVRETIEERVHEIHNAKRHYRNSHHKRENSTEANEVEDDAASLPLHAALDKLSAGGGEVVSDEDVRRCFTNKSLFANDELVKGRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZG9</accession>
    <name>A0A8H7PZG9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_006590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZG9"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="40"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="355"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="593"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="727"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="656"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="823"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="842"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="890"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="902"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2183584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="933" mass="104836" checksum="EDA004A32A8F2225" modified="2022-01-19" version="1">MSANHPNRTSLRNQKAKLAADYHDLLKELSATDTPVVGCYQLGKTIGEGTYGKVKLATHRLTAHQVAIKKIDRQHIPLITREIHHHRRLRHPNITALYEIISAEGCIHVVTEYCANGELFDVLAAEGRLSEPRARRWFGQLLDAIKYCHSHRVVHRDLKLENILLDAQWNVKLCDFGFTRECETRKMLETFCGSLAYAAPEVIMRKKYSGPEADIWSLGIVLYTLLTGELPFDDDHEPTMQDKILHLDYEIPDYLSEASQHLIDGILRLDPNERLSVYGILDHPWFSLDFEEVEDHYGSLTDDQSSVTSPHILFSQSNDSFTRVERDLDAITDCLRSQREDIQKMDVERERISHISWGNDVPPDTPTSTPRYSAPVPARYSTSSISSSNRLSSPSSLGVSPVGSPTNWRNEMDDMSMSSRSSYVPATATEQRLLNALQAAGFDADNMYKNVRAGSCDASSAIWYMLLEKLQREEENKQHKTGASSARNSVNRLSYRLSSPLGSVMSMPKGKDSAAELRRMAITSSAYTGKRMSDHQMLAEQPTPIETKDMQTQTTPSLDLPARPELTFEPRYDKPLPSPGAASLKRFINNNNFEKKQQSPSSSISSRSNNPGFFSSVKNLFGRREPLPRPSAPIMQWPQNVDDLPEGFTAQHHQRSQTQTSIQSDSRIMQSPPIYRSTSFGSRQRSLQLLNLPENEVDHMNYAQVSPVKPPSPSRNIHNLSIHLEKQQASYSMARPSIHMPPAPPRAALSADRADPEFAKRPIPSRLPKTISSSMQLKRAPGPPPTPSKEPREPDQQLPQQQQHHQEKYDACESNSSEGTHMESPLMEYSSPSSSTMASELSESDLSDDDEDQLVQATKIDASKPIEIVPEPSYSAPLPPKSSFAMRWQSPTSSPYGPSGTRTRLSIQNLSDSDVRNRMGRKVIVEEEEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0C4</accession>
    <name>A0A8H7Q0C4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Crossover junction endonuclease MUS81-like HHH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0C4"/>
    <dbReference type="OrthoDB" id="205514at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF28">
        <property type="entry name" value="DNA POLYMERASE LAMBDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Crossover junction endonuclease MUS81-like HHH" evidence="2">
        <location>
            <begin position="146"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2183573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="237" mass="26892" checksum="3D0BFB2D92BF5215" modified="2022-01-19" version="1">MIPMKHFHIQLRALPKEIILISSDEEYSPPASRPNTPISNSPSPVKSINSCGSPMQARTMEDIGLAYCRTLSIYSQQRRSKRSTQKSLSEEEQTTTSGDNMDISSSQPSSLEAIIDATQGPSAIAGEPRFRRGFACEHPVPSQFYNRELIEIFERMEHLRELDGDTFSAKSYREAVVALKCFPEELSSIKQLPHIRGIGKKITRMIEDYLRDGRVEDLGKIAFLRLVTVTRYTHYYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1G3</accession>
    <name>A0A8H7Q1G3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-aminobutyrate aminotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_006576</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1G3"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000013">
        <property type="entry name" value="4-aminobutyrate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF58">
        <property type="entry name" value="LEUCINE_METHIONINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2183570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="47559" checksum="AC10DB97AF1E38B1" modified="2022-01-19" version="1">MSTLQKLAQFGQRHIAKGIGRSTELVIDKGKGAYVWTTEGKKYLDFTTGIGVTSTGHCHPHVVKAVQDQAASLTHGQCNIFYHKPMLDLIEKLQPKMPSKSLDTFFFWNSGSEAVEAAIKLARHATKKQNVIVFQGSYHGRTIGTMSLTTSKTIYGAGYGPLMSGVHVAPFPYCHQCAVHKSSPDTFNINNCCNDPIRQLELVFKQRSAPSDTAAVIIEPVQGEGGYVVPPKDFLPKLREICDKNNVLLIADEVQSGFGRTGKMFAVEHWDVTPDILVMAKGIASGYPLSGIVSRKELMDKQPAGSMGGTYGGNVVACAAAKATLEVFEDEKILENTNARSEQLFSALRSRVPKLLPKGASVDIRGLGLMIGIEFSGVPAGFASKIANEARDKHDLLVLTTSIYETLRLIPPLNVTKEETADALERIIKSIEGAVDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1P4</accession>
    <name>A0A8H7Q1P4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1P4"/>
    <dbReference type="OrthoDB" id="2117820at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2183439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="356" mass="40744" checksum="5739B533DA3EA796" modified="2022-01-19" version="1" fragment="single">VEVQQSFTAAADFVCRMNVRAPITRLWHSNLQHPLAYKGGSRLFYRLNHSDSHSEDEKLLNNVQLKQPAEEQQVSYKPISSFPWVLSNDEPRIPAYPYPLAPSMWSLLNYLPTFAQREMSKYLGTRMLRLNTGFSYFPEQFLIGATLATRKAFEILSSDLASEKEEMSHSAESVFSPALLQKLRDARSQVDPDARFNISLPQVYDATVKDVWITLGSPQAFQKNRQYEIMQWMTLTIGVKAARQNEDEEAFSDYRGRVAKGLMDGAHFKVDVEIDADVEYKVSKPKSAEGDNDDSVLLYDRGRRPLIISFETPYFEPADRMVAGRDEDDEPIMDWGWRISDIDQLLAKEVVDSHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q230</accession>
    <name>A0A8H7Q230_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">INT43_000300</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q230"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000002">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000175">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048438">
        <property type="entry name" value="Yme1-like_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21232">
        <property type="entry name" value="Yme1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="381"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2184391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="783" mass="85883" checksum="711FBF2874371EB4" modified="2022-01-19" version="1">MSIQATTPITQHLLGLISEASLCLNSFRGSPKALSKQVNAEGLIKNTLTNNEANMAQVASRMQSLSLKDLPEVFQKTDVKSLNRAVANAMSLLQSNPALATEIAQATKSITAVNKPLGLATSWSRHRFMNNRAPNAFQQRRNLFGDAFSSSSTSGGSVRLLNQRKLAKLEHDANNTPLDPRKQAELYKELMRSKNPQAVITRFERGNFTHDEECWQHYIAALAQTGHADAILPKVMQRLEGGVPGATHKLPLSPGALQQALAGSGKNVRIDETAMHAGAGNKANPIYVVVEEARGYIFWRALRWLGITFTYAFCILTFLSLALENSGLLKTTAAQTEYEPSSQQAVKFDDVQGCDEAKDELEELVQFLKNPQRFTELGGKLPKGVLLTGPPGTGKTLLARAVAGEAEVPFFFMSGSEFDEMYVGVGARRVRELFAAARRKAPSIVFIDEIDAIGSKRNPKDQTYMKQTLNQLLVDLDGFSQTEGVIFIAATNFPELLDKALVRPGRFDRHVNVPLPDVRGRVQILKHHMKGIQFASDVDVSITARGTPGFSGADLANLVNQAAIQASREGVREVGQKQLEFAKDKILMGAERRSAVITDESKKLTAYHEGGHALVAYYTPGAMPLHKATIMPRGAALGMTVQLPEMDKDSFTRKEFLAQLDVCLGGRVAEEMIFGEENVTSGAHSDIVKATDVAKRMVRYYGMSEKVGPVGYDDDDMQQLSTQTKLLIEGEIKALVTNAESRARHILKTHADELHRLAKALIDYETLSQQEILDVMAGKPISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2D3</accession>
    <name>A0A8H7Q2D3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lysoplasmalogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_000566</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM86 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2D3"/>
    <dbReference type="OrthoDB" id="2133758at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012506">
        <property type="entry name" value="TMEM86B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31885">
        <property type="entry name" value="GH04784P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31885:SF6">
        <property type="entry name" value="GH04784P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07947">
        <property type="entry name" value="YhhN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2184653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="23269" checksum="B3EAAB189A7161F0" modified="2022-01-19" version="1">MDYVGVWISTIAQVGLLWSVYHELIGGVYLFKPISSFGFLVTYIESPHGPAKHGSLIGKGLLFGALGDIMLMFKPDWAFLLGLVSFLLSHICYTLAFVKLGVRWTSTASLIGVASSTAVLSQLLPWLIPNVEADMKIPVLVYMCAIIIMVIASLGSAANSERPLAQVLGAIAFMISDIFVAREKFVVAGFENAGIGLPLYFYAQIAIAYSAWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2E9</accession>
    <name>A0A8H7Q2E9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2E9"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2183799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="111" mass="12463" checksum="4BFA25FCF81C0F42" modified="2022-01-19" version="1">MQVQTAANGNRWVQCRGVTADPVLLMDSPYHFRFTQSFGTPTLPILNSERKQLFIAPHQSEDNLFSALGWLKVVAQAYIDTSNGPNPQSSFLIPLRSMRKPQGQLSFVNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q351</accession>
    <name>A0A8H7Q351_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q351"/>
    <dbReference type="OrthoDB" id="2289831at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2183796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="189" mass="21268" checksum="18D36E4C88055AE4" modified="2022-01-19" version="1">MGKKSKIDSGDYQETESVDPPPPYIAPEEPCASNTYENPYPQVPEELIEPSAPPVPETVETTESPTKQPRNSTVIQIRDSDYQAYPNSYHTEGTPLLNNDHTVRYQYRGFPSGAIIFLLGWGFPPIWLVGACCCMSSRNPFNVWWARASLIMFMLTMISALLAGVIVITVGPESWRIHFAIWIEKAKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3E4</accession>
    <name>A0A8H7Q3E4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_001009</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3E4"/>
    <dbReference type="OrthoDB" id="2435866at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF160">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="93"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2185096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="284" mass="32106" checksum="54BF3AE6F79160E8" modified="2022-01-19" version="1">MTSNTLDSMATQNQIDIRRTATTPNRTIMSVLDHSKPPEPNYYHPRSRSSSQNSENEFKDITPTRSSSQSSSDNSTIRSKGRSSSWTSQSQIPATMSGWLLRHNATHFTFTTPWKRYYYVLSDNALHEYKTDKSDSPHRDQLDLSSDTLVFVNEGFPGKTYVLEIRKPGRRMCLQCNDAESMKQWMHYLKQSIAQIKRSNSLQRSASITNSTIGRISQDETSSHSINENTSQTMHDTHTPPITSQPPQVIEPQSKKLSRTSSKLNDLPPQLPPPSRSPPPVPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4X7</accession>
    <name>A0A8H7Q4X7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4X7"/>
    <dbReference type="OrthoDB" id="2319449at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034726243" evidence="1">
        <location>
            <begin position="24"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="282" mass="30746" checksum="9053E03C29003A71" modified="2022-01-19" version="1">MKFSLAATLTLGFLAVTAPFASADSLSDQMDSAQKKFCGGIALTAPTKSQSFTEGSKVKLTVTRQPNSEKKIVNAVDIYSVGSGDKLKYLGSAWTGNYALNKQATLSVDISKYTKKVKLPAQFEFRTWVHNTAGPDCLLMSKVFKVVAASHKNDDGTDSVEDDGSSLDSNVDSGCFGVSIDHPASEQKVKKGSQFSISLNRDSASHVEDFKSVELYKVDLNTKTATKVKDTWTGDEHIKQIFNLKDTITSDDSNVAYFYKATATTQHNETCSFHGHAFYVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5D3</accession>
    <name>A0A8H7Q5D3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_002710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5D3"/>
    <dbReference type="OrthoDB" id="2418723at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034001247" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="25"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2186272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="207" mass="21484" checksum="4A0425BD61CCE6AC" modified="2022-01-19" version="1">MLKTTLLTLTAIVSAVLAGSVDITSPQQGEVWEAGKEVDIVWDAATAGNSPVSIMLASGPAKALLIDMVVANKIPASQGHYKWTVPSNLKSGKNYVIEVGPNMKDISFAGYITVKGVSVPSGSHVSHHPSATHSAHHSHHTSASASAHHAKAGTTALSQAPPHSSAAPKKHHHKKAKKSGKKSPKFTTIKIHPKPSHAPAKPASASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5E8</accession>
    <name>A0A8H7Q5E8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA polymerase delta catalytic subunit</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
            <ecNumber evidence="5">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">INT43_002651</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EC" id="3.6.4.12" evidence="5"/>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18033">
        <property type="entry name" value="DEXDc_FANCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05777">
        <property type="entry name" value="DNA_polB_delta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12091">
        <property type="entry name" value="FANCM_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05533">
        <property type="entry name" value="POLBc_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18801">
        <property type="entry name" value="SF2_C_FANCM_Hef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000861">
        <property type="entry name" value="Fanconi anemia, complementation group M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056435">
        <property type="entry name" value="DPOD/Z_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044749">
        <property type="entry name" value="FANCM_DEXDc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24055">
        <property type="entry name" value="POL3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="14" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="13" id="KW-0347">Helicase</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="24">
        <location>
            <begin position="187"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="25">
        <location>
            <begin position="539"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="22">
        <location>
            <begin position="2787"/>
            <end position="2944"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="23">
        <location>
            <begin position="2860"/>
            <end position="2918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="828"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="861"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="908"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1337"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1400"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1588"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1354"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1400"/>
            <end position="1429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAG2186213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="3060" mass="343798" checksum="EC8D050124DA5D04" modified="2022-01-19" version="1">MGCDCKINYVTKRVEFQNSQSRTTLTKICMSEPRSEDEFDSEFDDAILLAAAAEAENAMFDDFDESLLLRAVELTEARPQQTTSNQVIPRTIIASQRQKQTTVDSFFSSPETSISNAVQSSPQVCSPALQPDNAIAPFRTHISAPAPQTPPPPPSEDAQCAHFFDREACTTWVYPINYPLRTYQFNIVQRALFNNTLVAMPTGLGKTFIAAVVMFNYFRWFPTSKIVFMAPTKPLVNQQIEACFNICGIPQDQTAELTGAMPAARRKVLWNTKRMFFVTPQILQNDITEGVFPSEKLACLVVDEAHKATGGYAYAVAVRKLKHRHREFRILALTATPGTSLQVVQKIVDNLLITNIQVRTEDSMDIQEFSHGKSIQTVVVSLSYTHGGSGMLPKAVQVFRNSVFLPVLKALNQFKAINDIDPDRNTPYMLMQSRGIWQANSKSFNKFVQNTVFSNFLAADILSRAHDLLCQHGTGPFMRSMKATIAQIQADLDNGKHVAKSKANVARNPELIKLLRDLERMHEQPSYVGHPKMDKLLFAVLQHLNGSESSTSETESNLPGGDTRIMIFSSLRESVNEIVSFLSKHEPMIRCTSFVGQAESKGSKGLNQKAQQEVIAKFKRGVYNVLVSTSIGEEGLDIGEVDLIICYDSQSSPIRMIQRLGRTGRKRKGKCLLLLTELEERKYKQAKDNYKRVQNLISRPDAITYYPNNPVILPDGIRPVPDKQVLNIGEYLKPQTGKRKRNEVVDEFNSDGTLGLTQEDEFKRRFLQPLIRDAQTEVDVISHWMHPRRRLAENIYTPLQTTLSTTKFSGSKRSVQLVQLVTKMEQRILQPHDSQRDHEEGVGLEESVLSNNKNMLVLPARKKAKQSKISVPRSEPSEEHSETLEEQQNSVMLNDIASMTDTDLLSAKDVTRKESSSENTPVHNDIAHEANPQQESPWRHGISSEIEDQLQHLHEKPSFMLANPDDSGIFGSSLMESPIKPVARQSNNLQIENSAKPSASGQLSNDTLSFKFNDRIAPLFPFEMKDNAQERRNFERSSLANRTIPLQFSEKAQAIFIRKWQILQRTPGRCTLKVLSEALHHFFTTTSKMSKVDLCKALSDSVELDDIMLDMDDLELALSQEHGLTLKINPEQALTVTTKSDEAMSVDDEELEFDLGELDIANDPEFFLISDDPPYSETQVNSQTEVQVAPLQNFSLASPRMDPGKSHVKIIEPEPAQSKEYSDNGGNESFDFDVGELDLTILENKIDSEGGYGLVELTPPPRSLSQIPEIITLSSQSEAEEDHVANGKSHIRLALNKHAQDKHAQDSSTYRTPVRQNSISLKATSGRMTPTRRLYPEKRDISSRSAGTEHVQRDTISTTQDSSPIARRYLNTKGRRNIVFDSSPSSSHSALNENLSLTNAMSTSENNGSPASSPFTRFRPSTRNEQQGRNPFFDLEASESGEGCSSDMDEEERSSFLDSFIDDTAVDKSSVIISQDASKSPVNMYAFYRQSLMSPENALQNEEGKHGFANTRRPRYLQRILKNWEGTNLLETEANESLIEESRIASSALDSSNSQGHSVDIPDDEDSAFIKTRRRFLLSTRIAMVSVANTKRQNENDPPRKTSSSNELEVSEQPFNPAANLKKRRTGPAVNVAKSAFEDTLSVFAESDGLADKFDNTEKAWARKPAPEINPATDKLVFQQIEADEYIDYRINRPVIRFFGVTNNGNSVVCHVQGFLPYFYVPAPVGFLPMHLEALKRALISSIGIQDSVVNVELCLKQSIYGYHGDSKSPFIKITVNEPKMVPRARAKFETGLSIAGYDKPVLADMTYESNLAYLLRFMIDRKVNGSNWIELPAGTYTMKQNPVSQAQIEVETQYDKFISHLSEGEFINIAPLRVLSFDIECAGRKGVFPEPEIDPVIQIATVVKIQGLLIDFTGESKPFIRNVFTLNSCAHIVGTHTLEFYDEKELLQKWRDFLIEIDPDVIVGYNTSNFDFPYLLDRAKYLGVDKFPYFGRIKGVKSEAKDTKFSSKAYGTRENKAINMEGRLQLDMLQVMQRDYKLRSYTLNSVCAQFLGEQKEDVHHSIITDLQNGNAETRRRLAVYCLKDAYLPLRLMDKLMCLYNYTEMARVTGIPFNYVLVRGQQVKVISQLYRKASDQDLVIPAIRSEMGDEQYEGATVIEPTKGYYDVPIATLDFSSLYPSIMQAHNLCYTTLVSSSTIEKLNLVRDKDYIVTPNNDFFVKSERRPGLLPEILTELLAARKRAKADLKKETDPFKRAVLDGRQLALKVSANSVYGFTGATVGKLPCLQISSSTTAYGRQMIVKTKQVVEDTFTIKNGYKHDAQVIYGDTDSVMVKFGVDTLEEAMELGQIAANHVTKEFIRPINLEFEKVYFPYLLINKKRYAGLYWTNPKKYDKLDSKGIEVSAHADILRKVATTLNFLNFGTNFIQTVRRDNCRLVQTVIETCLHKLLIDRDVVGAQEFVKRTIADLLQNKVDLSNLVITKALSKSDYAGKQAHVELAERMRQRDAGSAPALGDRVAYVIVKGANRAAAYEKSEDPIYVLENNIPIDTKYYLDNQLSKPLLRIFEPILGDKAETLLSGEHTRTVNISTPTVGGLMKFTVKTATCLGCKTPLPKGACVEINIDNSAVCKHCKSRVGELYQKQLSSVNDLEVQKDMQDSSTTLERFNYDCIQTSTLPLFISTFIMSAMESIAPHGPHERVGITFQPRLTPKNSISHPINVNWMIPLEHLSFLSKSMLPDSFDLYDLAVASPSHSRFSTDHSQPPIRPPKLLGNLALSSCPGKKVRLSGPVGGRATINRDLDLDFARISRQFNITTIVCCLNDTEMHFLGAPWPRYYEAALKHNIEVIRLPMLEGSCPHSIEEVDVVVDIVVEKMARGENVLTHCRGGVGRAGLFACCWLLKNRFCLSAEKAIRYVRLRRSPKSIETMRQAEFIIHYARYLNKLSNLQEQDTLPDNNQDNVQQSQKILESGTQLTLPDPVLPQMMNHDIRLTIPNEIQIQHIEAQIRLADGFDTNMIGFHAPPPVAAPVVRSHTSPSILVWSQALDLYSLDSNEEAMQATYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5L1</accession>
    <name>A0A8H7Q5L1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_002741</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5L1"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2186303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="166" mass="18732" checksum="666A259A6E8BC32E" modified="2022-01-19" version="1">MDHGGHGDMNMCKMNMLFNWDVENVCIVFEWWRIETPFGLLLSSLVIAGIAAGYEFLRASSRAYDNQLLAADKKKDTSRRMDLEDDHGESESLLANTFVQQNTNMSQQQRVTRSVFYAILVAISFWLMLVFMTYNGFLMLSVVIGAGIGHYAFGGNLSSDRGIQCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q606</accession>
    <name>A0A8H7Q606_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Gpr1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002346</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q606"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2185908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="25250" checksum="693C81368ECB5CD4" modified="2022-01-19" version="1">MSTHSTDKNDITHHESITMPDERVHVHNNSSQAAAVAAHMPVAGQFDPAPLGLGAFACTSLVLGLVNTGQTDLFPSVAVGLCLGYGAVAQLLAGLFEARRGNTFSATAFCSYACFYFSYGIMLMPTSGFAQSAEAAGAAAASTASGAFQLPWAAISFLFFLATFKQPIIMRVFLGLIFLTFFLGTLGGFLLNPAVTKASGWVSILLSMTAFYGFAALLWTKEISYITLPIGAPAGVVKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6T2</accession>
    <name>A0A8H7Q6T2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_002751</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6T2"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="50"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="370"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2186313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="425" mass="47857" checksum="AE9D7C6FD0262B18" modified="2022-01-19" version="1">MDKKLLRSWWKRVTTDKPQKPHSDALHPTSDGSIFSTLLETSIQYACVNISYADDATKQQCYGQIPCIVAKCGAYLKDQGLYVDGIFRLSGSARRIGELQHMFDIPPLYGSQLDWQGYSIHDAANVLRRFLNSLPDPVINHKSYNDFRNVLADNPKYPNKETQVRRFQYLIDHLPLAHQFLLLYLLDLLHLFAANSVFTRMDSANLASVFTPGMLSRVDMQPTEYKQSQQVVKFLIDNQTLFSMPKANISRSSSPPPNNFVATHALPPLVAEPAALEVNSTSHTHSLATREKKKPADEESTRPNKPSENKPHHKRLPHVPSRHSVKREPDATKAPAMPVYRRSTTWLPPSHKPLDGVDIDAAKAAAAIRSGHLLPNERRKVKGLARSKTVPSKRPKYGPDDPLQVVHVNRGTSVRERKPDPITEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6Y5</accession>
    <name>A0A8H7Q6Y5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_002682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6Y5"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2186244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="161" mass="18668" checksum="544192A6859C4FF7" modified="2022-01-19" version="1">MELAEKFIEKVLLNCQRKELADVLLMIDIQLQQNNHEQAARYVKVLPDCVGFTPKMLMALSKDACLYGKRVLIVLSSDRLHDHYASSDAENASVAFTLALELFQRNERIKIAISEDEVNKEMGWFSASAWNLGVRCFKYRERRCSAKYFFYARKARELGYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q7Q1</accession>
    <name>A0A8H7Q7Q1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribosomal protein/NADH dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_002724</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q7Q1"/>
    <dbReference type="OrthoDB" id="10250268at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016464">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B8 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005822">
        <property type="entry name" value="NDUA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2186286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="93" mass="10346" checksum="8E0C24BF27F3EA2B" modified="2022-01-19" version="1">MSAWNSLSKSIKEVRVHFCQNSPASKGLKQFVAENYTGIKQANPNLPFLVREANGVQPRIFARFDKGVERKITLENASVQDVKNALENLAKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7X4</accession>
    <name>A0A8H7U7X4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Nascent polypeptide-associated complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">INT43_004897</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="14">Part of the nascent polypeptide-associated complex (NAC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the NAC-beta family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7X4"/>
    <dbReference type="OrthoDB" id="5065855at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22055">
        <property type="entry name" value="NAC_BTF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000003">
        <property type="entry name" value="Nascent polypeptide-associated complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039370">
        <property type="entry name" value="BTF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10351">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="11 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="15">
        <location>
            <begin position="11"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="NAC-A/B" evidence="16">
        <location>
            <begin position="253"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2172355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="381" mass="42119" checksum="2DA2B5C7E5ECC130" modified="2022-01-19" version="1">MDKILLQYGDVVLRQSDYATLAEGQWLNDMIIEFHSEYLEREVIPRDAKILLLRPATVHLIAHIQDPSQLHSALPPNLDKSQAIFIPINDGKPNVANSGSHWSLLVFLRSAATFYYYDSLHNSNINSARITARQLTPLLGIRQHPQLVSMWTPQQPNGADCGVCVIAATDFLVDKLLTIRGARINPSQLMQLSSADLAPTHKVRKGLRTMMKELSTFIANMNPEKLAKLQSQVRIGGKGTPRRKVKKITKSAGTDDRKLQATLQKLSVQPIAGIEEVNMFKDDGNVIHFANPKVHAAINSNTYAVYGRAQEKELTELVPGILSQLGPDSLASLRKLAEAYQQAQAQGGAGAEEDDEIPELVENFDKAEVSEVSETTEEKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8A2</accession>
    <name>A0A8H7U8A2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_008092</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00177">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF14">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1693"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="3">
        <location>
            <begin position="31"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1320"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1579"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="980"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1335"/>
            <end position="1345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2171712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1756" mass="194933" checksum="FE391DE0E9A21813" modified="2022-01-19" version="1">MSSSNSIQEYYERTIKEAKRYYKAVSLATDWSEIKLRTTKGSNDRIPQVHVFKRREQAKTVETFRATYVIDCDDTQKCLDGWESMLDNSESRILWDSTIEKCNTLNLLDENRKVIHILLKNKWSSNPRDLILIEDCERTENSLHYISTSLPPSKEQPKEFRPANPYVRANLTLSAINVEAINEKQVKVAVYYQIDLKGWITFSVSSYISHLILDCLGTMEKHGIPPNIANYGSGIQLLHREYDPQQKQLTIKYKSRVGWKSRDNSESEDDDIEESSQHMGSSLPSIASVPIESDTRDGRKRSISSSLETNSYLSSSMNRGHRGGFMNAGFMMSSSPTSRMRAPFGSLSKSSSFHTGAISASRSTSYLDLSARLQPNSKADQCPDTSIQIKLIDKKWSSMHSVCIEALAANRMAKNVEEMTKTLTKNVSAKCYKFSRLQQYLIEVGSSSISGLESEASSEHTGEDIDEEFLNGTEENVTILRIKIDSASSIDGESQEQEIMLNSRKVLVLEYIGHHTPGRSKSENGQFRGHDYFDVEGDVFGSDMTMYDDLKLPVRQADTPKTTSTSNESRSKLSIDRQADEQPKRSLPFKEPKPLADAQENFFNSAISEAAESEGSLSTNIDGYVRTYERQLPDGSKAVVNESNWKNCSIWDVKALIDCPSISYQWSSTYDSGQIIGNLSPRCTVHSAFFRSSWRSSLREHLSVNATYASLKRLRYVSLSFDGLAEDQTMTKQADKSEQIYLLNGWQIDSNDDESCSVKFLVQKEISGRSSSYSYNPIDGPPSDIVAKAKKSFDENEVPPTLAYIINARIKSIQYDKHKGSWRCQYELTNAPNDPLFPIKGSVAYIRLPRNILLTPTQGFNITIDPPCDNLLSVINLPSDKTGIWLRIEHDRNSLVQDGGSILLLVKRIDSKTPVQVNGSVTSQVDFDAYAGAVHFVAQEDLPIQLLEQLQGSFNNGFSTSKLQKQPVIASAINHQTNQKSFTASNAKDASSQLTEKEELQPSDKSDLFANLSVSTYDQAAAACQYLYRMSDQQFGWVHVSEKNGLLTQKRSGGTVPVETLSLDPIPANVTDSLEQRFPTIPEHLMLMKGIKVIEGFSVEEVASVVSDPGHLQQILRDSLQSVDVLKKFANGHACAKLQMKSWFPFKSRDVYVVSTTARDVSSTGQSTRILHATTSICNMNLPAEYVTPLAHLHLSGWILEAVDPYTTTTNHPIPSTRVTYMGCIDLGQSVPAYVSNMATSNLIKGINRVESVLKSNGPPPRLISPIPFLEFRSGELHWSGHGNVFTGDHQIEVEYVQSNQRLIVSSTYDRAKLLPHQSEAANKEDGSPILKHTPTPSFSSTISKSPLLADRRGSAPGRIPLGVLSNKAMLVQSKEALALSNSKNKIALLDVVADLKSFPRGYNIEVKFSVEVGHSIDLSDKLTARIEQLDPEPSHLIGSAGTLPPVKHNIKVKLDLDAITKEMTKELYSQLHNYKLIFSLDPATEEQLSARTNKLTISGVLGEDEDKWKGITMINGQEIMLGTDAKLASISSLRASSTDTVSNHSVDASEPETSISAVLLNVVSHPALSWLSNLSRVNTPSQVPDRDDATSPTSVIGNDMAQSPVEADGVSRIVTSHIQDIGNMVLSPFIPSSPAPEATTTPTDEPMPDWLMSEVDRRLIEDGKVAGNTASETQTNVPTPSHSRSHALLRQFAIVFILCILLGILIRSFAIMAIDADHEVAINKLLEMNPANIKQIWRMRWFGGWDIEILAVKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8M2</accession>
    <name>A0A8H7U8M2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_005399</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8M2"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032:SF1">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2176166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="426" mass="48859" checksum="9E5B1730C6E911F5" modified="2022-01-19" version="1">MPSLSDTEGAAFQAARPSPFASPPRNTTPYMKQQPSSPPRRQSRHDSTSSRRMSNTTPEKESVSATVSWPIALAIVPTLGAFVAGSAEVWSDLIMVLLILYYTYKWVTVPWNYYEGARSRRILNQNAQLQVPHNMSDEKKAMEIKRKALVARELRQHELAGLLLVILSPILAGLSLQYSRRFLSNQERYLSSFNIVVFVLAAEIKPMVHCMTMLKDRTLYLQSELQVQEGEVEVLRERVYELEDELQILKKAFATKKDLGQVTNGINPTLNQLAKSVKRSEKREMMLRNYSEERFSFVDAKMREFDEYIGKRMEYDRLRASKSYFIGLIFLPMTITFWTLKRITHLLPLPKTLQLASSIPPKPIKASHDLRSPQAIDSAKTNHIPDATQVEREFRYRRQMSSDHNESSYLSGEESVAAFGRSRQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8Z2</accession>
    <name>A0A8H7U8Z2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_000124</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8Z2"/>
    <dbReference type="OrthoDB" id="2260257at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034456136" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="28"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2172777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="215" mass="19509" checksum="447820319E312337" modified="2022-01-19" version="1">MKSIIAAIAALAVAVVSAQSTTPVSITSPLQGSSFKAGGQATITWINANVPTLAQVQLVQGPATALQPVAQVASNVATSDGKLTWTVPANTPAGSDYAFELGASPNIAYSGFFSITAGDGSAAGNSSASGAASGSSAAASSAPAASGAASSGSASSAPAASGAASSGSAASGSASGSAASGSPAAASSSAKSGASSVKAGLVGAAAVAGAAALLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9H5</accession>
    <name>A0A8H7U9H5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_009120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9H5"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034112002" evidence="2">
        <location>
            <begin position="27"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="263" mass="29930" checksum="89293BC72C9CEF3A" modified="2022-01-19" version="1">MLILLLIPAGYVMKALVIMSIRLTDGDDLINPIDVLWADLTPKVSQAGISKSYPLYSPFPVCDPNVQSTSHALFTNPIAYWLLFPFSDDRSWHVILCKLQHFHLGFFFLGSVNNVWFTYKILGDMFDIVLGEVTQNNGAAVLSWRAQIIKTGLLLYSSMLVCVFWIHFNLFAFRTEATEIGTAAFRLKNFLAELPLWAVRWVTLGVAVGEFAVRSLYGWLRNAMYQVEEDEILSIDEQEEEMSANTFPANARAWFSRHVYALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UA60</accession>
    <name>A0A8H7UA60_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Malonyl-CoA decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UA60"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050080">
        <property type="term" value="F:malonyl-CoA decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001294">
        <property type="term" value="P:malonyl-CoA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.150">
        <property type="entry name" value="Malonyl-CoA decarboxylase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.90">
        <property type="entry name" value="Malonyl-CoA decarboxylase, oligemerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038917">
        <property type="entry name" value="Malonyl_CoA_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007956">
        <property type="entry name" value="Malonyl_CoA_deC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042303">
        <property type="entry name" value="Malonyl_CoA_deC_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035372">
        <property type="entry name" value="MCD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038351">
        <property type="entry name" value="MCD_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28641">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28641:SF1">
        <property type="entry name" value="MALONYL-COA DECARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05292">
        <property type="entry name" value="MCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17408">
        <property type="entry name" value="MCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malonyl-CoA decarboxylase N-terminal" evidence="2">
        <location>
            <begin position="53"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Malonyl-CoA decarboxylase C-terminal" evidence="1">
        <location>
            <begin position="154"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2175370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="50848" checksum="A75219A3488FECF6" modified="2022-01-19" version="1">MQKLLSTVISEDNASPVKGDLMPSVVVKSCCELYEGLDQDEKIKFFEILSRDFGVDRKLAAAASSSYLKLVSSEATSDSQLWKAENILKNTLEPSHSKFFDRVNQLPGGMKFLVDMRADLLEIIGAYKHRQDQIGHLISLDASIKYKLQNWLFGFLKLERITWQSPAVLLEKIGRYEAVHAVKDWRDMKRLQYLMIVSSSRRVGPRRRVFGFFFNNMPTEPLVFVQVALVDAMSTSIQKILTEDDLTTRQDPQKLSCATFYSITTQRGLNGINLGNFLIKRVVRDLKKEFPQIQTFATLSPIPGFRGWLRNQVEINEDIRRELEGVNYFDSAHEILDTADWIRDRKKADAIKPVLMRLCAQYLVSERRGNVALDPVGKYPLNSHKGIAESFSIMVNYNYMLDHIEENNEQYLAGGIITISEPKGESAKTQTWLRSRIGHNVRTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAJ6</accession>
    <name>A0A8H7UAJ6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tryptophan synthase beta chain-like PALP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_000203</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAJ6"/>
    <dbReference type="OrthoDB" id="271064at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018114">
        <property type="term" value="F:threonine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070179">
        <property type="term" value="P:D-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000005">
        <property type="entry name" value="Threonine dehydratase catabolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050">
        <property type="entry name" value="SERINE / THREONINE RACEMASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050:SF1">
        <property type="entry name" value="SERINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="9">
        <location>
            <begin position="21"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2172853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="335" mass="35629" checksum="4AED5B53C0E69C1A" modified="2022-01-19" version="1">MTGLSFSDIEAAAARIQVHKTNVVSSSILDQIAGSEHYAKHLLFKCELLQKTGSFKFRGASNAVMSLNETDARKGVCTHSSGNHAQALALAAKIRGIPAYVVMPSNSPQVKKSAVRGYGAQVIECEPTLQAREDAAKKVIEDTGATFIHPFNNYNVMAGQGTIGLEFVQQAQEMGTPLDAVIVPVGGGGMLSGISTAVRHLSPNTKVFAAEPINVNDCSRSYSAKSHQLNAVGATSVADGLLTNVGTNTLPIIMEKVDGVFTVSEEDIIRTTKLVWTYLKLCIEPSAAVGVAVALYNKEFRAKSEELDLRNIGVILCGGNVDIVKIARLIESIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAX1</accession>
    <name>A0A8H7UAX1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_005383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAX1"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23454">
        <property type="entry name" value="beta-trefoil_Ricin_GllA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450:SF1">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="6"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2176150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="281" mass="31935" checksum="F89C60F577433A33" modified="2022-01-19" version="1">MSTFPQSYFYIKSRQSGFVLDVFDGGMTNDTHIIVYPQKYNDAANQLWSCEDGFLINKKSGLVLDIRGGDLVPNKPIIQYARKMTLAHNQRWGYHDGYIHVLADPRLVLDIRGGESKEGAPVILYERKHQQNSNQQWTLEPYGNSGHGQQHPVQPNFYSQQQGVGGYGRPDNEHQGYQVPRPENLCDAHREVYKEKKQAHLSHELIAGAAAFEAVRAYARRQQDEGQPIAHPFAKEAIAAIASAEVVKLMEEHNWGGDKEQTKRAAEQAAQNYYSREYESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UB74</accession>
    <name>A0A8H7UB74_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_002001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UB74"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000217">
        <property type="entry name" value="Methyltransferase protein 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF80">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="61"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2179151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="212" mass="24689" checksum="D9585EC8189C56E5" modified="2022-01-19" version="1">MVASTSQEVIPEDPTAYKTQEYWEERYRKESSETTFDWFKTYAELKPTLNQTIPSKESSILMLGCGNSTLGEDMYDDGYKNITNIDYSATVIQQMAERCSDRPEMKWLEMDIRDLKFDDKSFDVVIDKGTMDALMCDRGDVWDPSPELIKEVKAEVDEVTRVLKIGGKFIYITFGQPHFRKRHLARDCWDGIKVSTLGEAFHYFIYEMTKQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBP8</accession>
    <name>A0A8H7UBP8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_005129</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBP8"/>
    <dbReference type="OrthoDB" id="2260257at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034016822" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="31"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2173709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="205" mass="19777" checksum="66293DA88354FC5E" modified="2022-01-19" version="1">MQILSFAILAAAASIVNAQAAAPVAPVSITSPLTGTVYTAGKQAIISWVSPNTDSIPQIVLAQGASTALQPVTTIATNVSTASGGYTWDIPANLPPATNYAFELGNSPNIAFTGLFEIKGPNGETGTNSSASALPGAAATPAASGAPATASKPAGSSGGSGSSGSSNAASGSSQASTSTSTKSDASKLAASGMVVAFGVASYLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCM3</accession>
    <name>A0A8H7UCM3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCM3"/>
    <dbReference type="OrthoDB" id="5511684at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH" evidence="1">
        <location>
            <begin position="85"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2178025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="285" mass="33082" checksum="1379415B78EEDB35" modified="2022-01-19" version="1">MASKELPMPSRQQTVYDNWKIVSNGRHDKSFKPDHHFGRKKVDWYLSRDLAVMLTEDKAIKLVFEAKGDGHSEGDYMVEDRANICVSCGRPDALTLHHIVPDMYRKWMPEIIKSKSSRDLVLLCKSCHLGYESHADDYKNSIVREYDMPLEGSGWILTPENHTVRKAASAIIKYRDGKLPGMPLERLKQLESVVNTYKADLNVEESFDDVLLVAIELTDRHKGPHFIEHGEFVVAKLMEKEVSSESQVRWPDLEAFIKSWRRHFLTNCDCRYLSARWKIDGNIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCX8</accession>
    <name>A0A8H7UCX8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WDR5-like beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_007631</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCX8"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000228">
        <property type="entry name" value="COMPASS-like H3K4 histone methylase component WDR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059122">
        <property type="entry name" value="Beta-prop_WDR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25175">
        <property type="entry name" value="Beta-prop_WDR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR5-like beta-propeller" evidence="5">
        <location>
            <begin position="49"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="91"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="133"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="218"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="260"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2176977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="348" mass="39001" checksum="A7A22E28DDDFB8D9" modified="2022-01-19" version="1">MDQQEKVPDERTATDDSRVEKDAKRAKTEPQAPAKVEVRKPQYELKYSLVGHRMSVSSVKFSPDGKWLASCSADKTIKIWNALDGKFEQTLEGHTQGISDVAWASDSLYLCSASDDRTIRIWSLNSRETVKILRGHTNYVFCVNYNPQSNLIVSGSFDESIKIWDVKKGKCMKTLSAHSDPVSAVHFNRDGTMIVSCSHDGLIRIWDTATGQCLKTLVDDDNPPVSFVKFSPNGKFILASTLDNTLRLWDFHKGKCLKTYKGHENNKYCVFASFSVTGGKWIVSGSEDHSIYIWNLQNKEIVQKLEGHSDVVLCIACHPTMNIIASGSIDKDKSVKLWFDRSAPQPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UD22</accession>
    <name>A0A8H7UD22_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_008713</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UD22"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF392">
        <property type="entry name" value="HAP41P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034135021" description="GH18 domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="25"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2181131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="384" mass="41559" checksum="2CDDE9FCCD8C3342" modified="2022-01-19" version="1">MISTSVIGLLAAMAASVSAAGSNKPELIAYVVDWELPTNIQWSKLDHVIYSFAEPDQSGKLGNFNTTQLEQVVQQAHANNVGVSLSVGGWTGSRYISDILSKSSSSFANTILDAVKQYSLDGINIDWEYPNSQDGMTCNTRSAQDLDNYLALLKSLRHGLGSKLITLATGTTPFNDQSGDPAKDLSDFASVSEIFLKLIFTYDINGNWDPTTGPNSPLKAASKGESTSVASALSAWKSAGIPSKQLSVGAAFYGWTARTIATTAQSQYVRFTKTQIKGDQYDTMSADPCPGAIKSYSGEMQWRSIDSQGIDAGRNGWTVKYDDTTQTPWAFSAKKKQIVTYDNAQSLEAKAQYAKQEGSGAFIWSLEMDDPKHTLLNALQSVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UE97</accession>
    <name>A0A8H7UE97_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ARM repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_005493</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UE97"/>
    <dbReference type="OrthoDB" id="2017782at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052645">
        <property type="entry name" value="Pumilio_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093:SF1">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="344"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="433"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="553"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="616"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="689"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="183"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2176259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="975" mass="107722" checksum="78C461864AF98F0B" modified="2022-01-19" version="1">MSNNHSRNHSFVRNDDWQDSDALGRQAIPSSLLSDVNHLHNDIPVNVSLMRMPLENDAHNKNVRPSNDPRHHLIQSARRRRAGTMPSMQFIPENGAMGLPEPHYSMLSSDLSGRNRSGSLTLPSASVSAAFGNPIFSTSWATNEFQPQMIPVNDQLLGEDDTNSIVQTLSTLGLDDSDVVGKKHASSQSSVQPSMIRSPTESSMSGYHTPQTPYGPDSSLYETRVAPSIVYAGSNAYNSTENYLGNQHNRPRSVSVTVPERNREGTFGQSMMNASQWGPNVYQTQPQARAGPPNFQSTRNRALSVGDTEWLRAQNARSDIDQNLDFLPYMDRGTPATGNATPTRSLWIGCIDSLVTQEQLLQTFSPYGLIDSVRLIADKECAFVNFVHIEDAIRAKEDILTLHNGRIGDTVVRIGYGKNDGPLLDSSVLQPTRALWFGNMSITLTSNDLYDVFKQFGEIESARVLTQKNCAFVNFKYLESAIRAKEHVQTTNLLGPNTRIGFAKVPTASAVGSNPLADHNLTDEPSDHTTKMASSESRELMKVELLDIVRMLAPEEAVNQLLSDEFDVLKEYHDSIPNVIEFGPERRLDAAALRELRKRLDRTDAETDEANLVADECMEEIVELSSDYIGNTVVQRLFELCDDNVTTKMLECIAPHLAAIGIHKNGTWAAQKIIECITTPEQMKLIRVHVGPYIPPLLLDQFGNYMVQCCLALGDENNQFIIEAIIENMNDVAQGRYGSRAIRAILENPSVSKAQQKLVAAAMLQHAATLITNPNGTLLLNWVIDSSGFPGRYQALANRLAPNAAYYCVHKTASTLLLKLINQSQDLNAQKTLLCSIFDNDKKLPEILSDQVCGLPLIQKILGGAEVDGTLRQYAADKIRKNLEIQGSSSGQRALHDLSGQQKFSPPAHTSGMAAVSTLYTTHQTPNYYMVPGQSMLASMGGTDYIPARANRSHYQPIQPVDYRTQPNGLIQDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEA8</accession>
    <name>A0A8H7UEA8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEA8"/>
    <dbReference type="OrthoDB" id="2108at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43799">
        <property type="entry name" value="AMINOTRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43799:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="1">
        <location>
            <begin position="35"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="390" mass="44342" checksum="87212F39D652999C" modified="2022-01-19" version="1">MTWDTKTQTFHGGQEHRFIHNFVEDFSVTTNYLGTPKAALEAAKDSVSNGNYEEPFNAIILNQNVKKIVTCHHYPPADQEPAKSSLAEFLWPNDFQQFKDRLLLGNGASEVIDLVIRAAKSTIKSDSTLTWKSGPWDTQYKEYYRSAESANMRILDGNSKEVANVLCIVNPCNPTGDYMPLDEIKHWIEKNVHDGGFVIVDESMQPWHSANFRDDSLTQQAEFAADLYSRRNVSLYVLHSWTKIWSCTGLRLGSIICPTAEHCSELKRAQVPWSVNTPALAFLDSVVKDQQYMQETWDGTSQLRSYLIEQLSALPASKRENFEYKGKDFLSWVWIEMRSEQVATEAVRLAKEAGVPVRSGQPGYIRPTHVRVAVREKQYVDVLIAAWQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UER4</accession>
    <name>A0A8H7UER4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_001774</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the GSE complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UER4"/>
    <dbReference type="OrthoDB" id="26136at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11385">
        <property type="entry name" value="RagC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000643">
        <property type="entry name" value="Small monomeric GTPase (Gtr2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039400">
        <property type="entry name" value="RagC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="292"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2178927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="424" mass="47613" checksum="6C71E992BFAA4477" modified="2022-01-19" version="1">MSNVLVNFLPPVHLKPNAGYSAQYDDYHYQATDNVSENGEDNTAGHKPRILLMGLQRSGKSSIQRVVFNKMPPNDTLYLESTTKIQKEDVTRSFIDFQVWDFPGQINFFETAYDSQEIFGEVGALIFVIDAQDDYREAVNRLHYTVTSAYRVNPNITFEVLIHKVDGLSDDYKIDTQRDIQQRTADALADAQMEHIHLSYYLTSIYDHSIYEAFSKIIQKLIRELPTLENLLNVLCSNSGIDKAYLFDTLTKIYIATDSSPVDMQSYEICSDMIDVIIDIECIYGAQNSASNGTTPSISGTDEDRSALASSPTVSAGSGGANGFGGADSLQEQLMSEQSQSTEREAEASSLIKLTNGDVLYLREVNRLLVLICILRQESFEKHGLIDYNFQCFKEAITDVFEFSNQRNKSQLADDNNIVDNNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEX9</accession>
    <name>A0A8H7UEX9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEX9"/>
    <dbReference type="OrthoDB" id="5771378at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052729">
        <property type="entry name" value="Acyl/Acetyltrans_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041496">
        <property type="entry name" value="YitH/HolE_GNAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47237">
        <property type="entry name" value="SLL0310 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47237:SF1">
        <property type="entry name" value="SLL0310 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18014">
        <property type="entry name" value="Acetyltransf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="320" mass="35762" checksum="9060E51FDDAB78A3" modified="2022-01-19" version="1">MARGLQIRQCTLEEAKSCFYEWAKAEQWNPGLEGAELQQVYYPTDSQGFFVGSIEDPDIPGKEKIISAISSVRYGLESGWVGYYLVHPKERSKGYGHAIFKHAILHMGDRPHIGLDAVIPQVHNYEKSGFTSVWENQRRVGGIDNVISKLSSLESLTDVSYSKMCDVPIDQINDLEFRYNGFIRPKFIQNWVEFHSQSEKLGRFGYAIMDHGRLVGYGCARAATTSFRVGPIFAESLDIAKALLYKLATSVKETMDASNDIPPSINPNFEVDICAANPQAVSFYESLGMSNALPTKRMWKGQPPKVDIDGIYALSTLELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEY4</accession>
    <name>A0A8H7UEY4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEY4"/>
    <dbReference type="OrthoDB" id="10443408at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2179137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="451" mass="46486" checksum="2AA8BE8E9835A3A9" modified="2022-01-19" version="1">MAVTIDEDDSIWKLQDMPDSVYEVGNQPATIDIKAVELAPDMNKEIESTTTSNAWEATATSSELEPTTTWNEAEAGETSNWRDTFQGLEISNIDDKPTPTTSTDVEYQDQQMTGILGTVPGIINEETSVASSSSLSTFPAVETEMPASSALLEEISNNTPSSTTDSIIEAAYTEPANVAYEAPTLPTASMIIDHFESESTSSTDIYNEPQEAPIAMNAFSSSTSAFAEETQVPQPSIKLHIPDGNVQKSNGPANATPQPSIRILPAFPGNTDNRNVAGQANPPPAPPPAADKSPDPKDAKASPPPPAGKPSASTPPSNDPAKPSNSPATGNPPKESNNGSSPPAGTEHIPNSPGGGPSSSSSPSRPSSPPGGGTPGGSRGGPGVGDYGGPFSGGQGKSGSSGGKTTDEDLGAIGQIGVFESSGASQHLALGSIWMWIVALVVIWTTLKHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UF62</accession>
    <name>A0A8H7UF62_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="3">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_006492</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UF62"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000026">
        <property type="entry name" value="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="7">
        <location>
            <begin position="27"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2183486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="445" mass="49320" checksum="9870F14CC7D87605" modified="2022-01-19" version="1">MSQVHGTAASTEEAQGEVITKKLIGVRQIVLNRPKRLNALNLNMIRAITPKVLAWNGSGLANIITLKGNGRALCAGGDVRSVVEAAKANHPDTPEYFTSEYQLNHLIACLDTPYISIMDGITMGGGIGLSVHAPFRIATENTMFAMPETAIGLFPDVGGSFFLPRLDGEIGTYLGLTGARLQAEDVLFAGIATHFVPSSRLEALETRLSELESSNYDVINSAIEEFAADYDPEVKFSLGGETRKAVDRCFKFNTVEEIIEALDKESTEWATKTKAILMEMSPTSLKVTLQQLRIGAKRSITDCFKMEHKLAEKFVVSKDFHEGVTAKLVNRTTPKWDPSTLADISNDSIISEYFEAPAERQLNLLSPKDFKQYPFRKYGLPSEEDIRRVVTGDAADAILAEPITSNDIVDWFIREQHGKFGVEQKVREVLNRKTKIEGDVLRWVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFI8</accession>
    <name>A0A8H7UFI8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_003251</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFI8"/>
    <dbReference type="OrthoDB" id="201153at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="5">
        <location>
            <begin position="53"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2177998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="407" mass="46162" checksum="792DFB8477EB8484" modified="2022-01-19" version="1">MLSEKNIDRLVEKLSRMRGAALKMGQMLSIQGIQAANSGQSMLPPQLEQVLLRVHDSANYMPEWQMEQVMKEQLGSEWKSHFSSFDPVPIAAASIGQVHAATLASNGMALAIKIQYPGIVESIDSDLNNLKTLVTFSNLLPKGLYLDNTIRVTKQELAWECDYLREAGNATRFKELLSGDERFKVPAVVKELSTRMVLVSERLTGQVLSKAPTESQEMKNKLGESLLRLCLREVFSFRFMQTDPNWSNFFYNKKTGQIELLDFGACREYSSDFLNKYGKILVSAARGDRDGVWEHSKALNFVTGYETPVVWQIMKEAHIDSVMVLGEPFRQDAPDLYDFSTQTVTARVRDTIPVMLQHRLTPPPDETYGLHKKLSGAFLLCTKLQSKFDTKRVWREEVMSHFNPATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFJ7</accession>
    <name>A0A8H7UFJ7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_003281</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFJ7"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="162"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2178028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="219" mass="23972" checksum="BA14F02E80EE1299" modified="2022-01-19" version="1">MQFAKKASLKKQQKSSCGGSKHMVSSNIEPAIALKPSSESTASAPARYAASISSNEEKPSSEIEADVMVKPIEIPPSSTTEEEQLEDLELEDPTGKSWSASLAAASMDSSSDESNTKDNLNVIVIRDYAYPTSHPMHRGIPLSPVVKATRPISEISLSSSEFTGRQARALYDFEPETESEIAMRAGDIVWVQYRQCEGWLVADVEDETGLIPEDFVEWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGR6</accession>
    <name>A0A8H7UGR6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_008654</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGR6"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2181072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="241" mass="27455" checksum="18B2413CDC818A73" modified="2022-01-19" version="1" fragment="single">FVVLPSMSDSSPLRKFKLVFLGEQSGKNAERYSIAKCPEIVFSLPCPEMLSSSWQDLPYYSFYVRHLRQHLPGIDFLSKTMYLEDRTVRLQLWDTAGQLDANHQERFRSLIPSYIRDSSVCIIVYDITNRNSFMNTTKWIDDVRAERGNDVIIVLVGNKTDLNDRRQVSIEEGEKKSREYNVLFIETSAKAGHNVKALFRKVGHALPGMDSAMGDGNREQMTRVDLSESSATKEEPSSCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHP0</accession>
    <name>A0A8H7UHP0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin reductase</fullName>
            <ecNumber evidence="8">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_007034</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="8"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHP0"/>
    <dbReference type="OrthoDB" id="371245at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000064">
        <property type="entry name" value="Thioredoxin reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="10">
        <location>
            <begin position="7"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2182107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="334" mass="35846" checksum="377B2B1925CB7D0F" modified="2022-01-19" version="1">MPANHRKVTIIGSGPAGHTAAVYLARANLEPTMFEGMMANGFAPGGQLTTTTDVENYPGFPEGILGGELMDKMRAQSERFNTEIITETIAKVDLSQRPFKLWREGNEDESEPTDTADALVFSTGASAKRMFLPGEDKYWQNGISACAVCDGAVPIFRNKPLAVIGGGDSAAEEAIYLTKYASHVFVLVRRDKLRASKVMADRLLRHPKVTVLFNTQATATHGDGSLLNALTIKDSNTGEEKSLAVNGLFYAIGHEPATSLVKGQVELDSEGYIVTQPGSSLTSVEGFFAAGDVQDKRYRQAITSAGSGCMAALDAERWLSEHELEGEVPAASPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UI36</accession>
    <name>A0A8H7UI36_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonine aspartase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UI36"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04514">
        <property type="entry name" value="Taspase1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037464">
        <property type="entry name" value="Taspase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF8">
        <property type="entry name" value="THREONINE ASPARTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="2">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2182527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="38777" checksum="5B50883B3DD19AAA" modified="2022-01-19" version="1" fragment="single">PQFAKSDMFARACRAAMTQIRNGGTSLEAQVSSLFHGCQIQDDPSTNSGTGSNLTLQGTVECDASIMTDQGRFGAVGAVSGIKNPIYVAKKLLDVAQEGLLPLGRVSPIFMVGPGAGEWAKEHGLETISNSRLLTDSSLNTYLNHMRRYHQANDSARRQKRFKLSSDAEDDESDSLGHDTVGAICVDAIGNVASGVSSGGISLKFPGRIGEAAIFGSGCWAQKMSGNADSMACSCTGTGEQLMLTSLSQQFSFAMQENVNIHEAMKKTLQSKFLDDPVLDTFPEKNAGLLAVKFTSRVKSSRCDIVELCYGHTTQSMGIGYMSANHGKPQFKMSRKSPDGNEQDIVCSSLMFKLNKEALRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UI37</accession>
    <name>A0A8H7UI37_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase family 71 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UI37"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034300913" description="Glycoside hydrolase family 71 protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="48308" checksum="9ABB9B0C33ED765E" modified="2022-01-19" version="1">MKLFFIAQITAFLLAIGLDFTIAAPASTHKASSKVSKDASDSPKMVFAHFMVGIVASYQAADWANDISLASASGIDGFALNIGADSYTETQLTLAYNAAASKNFKLFISFDMTSITDPTRISNIIKTYTSQSAQFKVDGKPFVSTFVGYGTVDWSSIESSSGVQLYLVPNWQANQIQGDSTISGAFSWIAWPSTNNQPIDSNMTTASDEAYISALAGKAYMAPVSPWFFTHYGVNSWNKNWIFYSDYLWFQRWEQILQLKPDFVEIITWNDFSESHYIGPLHPDNPSVYAGDPNTGAVEWVTGMPHDGWRDVAKAYITAYKNGASSPTVTKDEIVYYYRTIPKGTTCSDSVPQPTGYQYDEDNVYAITMLTSPGTLTITSGSKAAVKYSVPAGISLWSAPMGVGTQTFALQRNGATVLSGSGSKQISNTCTVYNFNAFVGTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJS7</accession>
    <name>A0A8H7UJS7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_007308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJS7"/>
    <dbReference type="OrthoDB" id="1594986at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2182378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="69" mass="8062" checksum="F372B6B15A00C60D" modified="2022-01-19" version="1">MTTNYENLRKIVTGDITVKYICGNEIRRVSINQTPTHDELCLMIHRLFAHKISNVENIILRYTDEGKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UK91</accession>
    <name>A0A8H7UK91_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_000750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UK91"/>
    <dbReference type="OrthoDB" id="2321311at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="105"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="5">
        <location>
            <begin position="429"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2184837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="61953" checksum="8BCF69DF014C6272" modified="2022-01-19" version="1">MGNQEIYLSENNSPARSGRTVRAITTAVLLTAACGYFFGSGIDLSTPEVPGAIGYKEGNFTWTKCYDQYDCSTLEVPIDYHNPHSAKFNLSLIRMKATEEPSYGPLFVNPGGPGGSGVSLVQLAGDVISKSVGGHYDIIGFDPRGVANSNPIRCFEDGTESKFFLANRGFYLNPGDNPANFAIVLEAYSKQCIRKNPDFLPYVSTAFVARDIDALRDAFGQELTNYWGFSYGTFLGATYVNMFPDRVGRVLLDGVTDPTTFSGEIVDWISTSLIHTEDGLDKFGTSCEEAGPEKCALAHPDKALAFDGEHYVAPTIRAFLKRMAYHPLLVEGSPDVILQTDAAALIFAATYKVSDWPAVAEAFAQAIYKSEGNGFMKWKKERQAERCPLVEEYTLDAMPILCIDGHHNDHLNLTSYLEGVDKASKNVSPLAAPLWGSLFAQCLYWKVKAAERFTGPWNHGLKNKIMLIGVTGDPVTPVESAEKLERLMDGNSVFHKHHGWGHCSTGQSSKCTTKVIHDYFANGVLPEKGSECPMETVPFQTAFETFDNGISVDDYTRLANALKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7ULT6</accession>
    <name>A0A8H7ULT6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7ULT6"/>
    <dbReference type="OrthoDB" id="2260662at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2183519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="175" mass="20004" checksum="9B01669EF90DA638" modified="2022-01-19" version="1">MHSSVKGRAQIFFLSEKGSETPTQICGFFFDETKTRNLGLAGRLLEDEPFRNHENCCLEPRAKYRVTLHDYVTKEYYDIPVVKRAIDDDAGSLETDCAVADDSGTTETTMSFETDRFVVDQIAWEHCRKYLGKLYNELVSKIEDVDKENVNAALTEKYDLVVCYGQMYISLGKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UNE5</accession>
    <name>A0A8H7UNE5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UNE5"/>
    <dbReference type="OrthoDB" id="9983919at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12108">
        <property type="entry name" value="Hr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585:SF1">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2186158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="195" mass="21945" checksum="3B13314E55CD96C7" modified="2022-01-19" version="1">MAQRALKSTHSIVTKVVEDHNTVKAFWSKFKKESDKTEREKLANQIIYEIAVHSHAEELVLYPAIERNLKEEGKKLVDESRAEHAEVKKKLYAVDRMSSGDPNLVTQLTATMEVLETHIEEEENDILPKFEKATDEETLKTLGGAFDAVKHTVPTRPHPWAPDKPLMESLVGLATAPVDMLRDAARSATTGFKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UP17</accession>
    <name>A0A8H7UP17_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">THO complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UP17"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021861">
        <property type="entry name" value="THO_THOC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265:SF0">
        <property type="entry name" value="HPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265">
        <property type="entry name" value="THO COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11957">
        <property type="entry name" value="efThoc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="631"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2185829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="807" mass="90552" checksum="BEF3C1EB49F50955" modified="2022-01-19" version="1">MPEFDAFRVKAQSALTHCLTEAQAYRAKAQVQDVPFSFFQPLIDQQIAPLVGPDNGANVQLSADPKHDWRKNALELIYRQTLYDIVISYEEPDDTLFQQIFDCLDIVLLSSESGYVEPVTVLTLIEELLEQQTIHGCEKLFEYIESRKTKLTVNMVPGKGKGLVLLRMCNEMLRRLSKNMSTVFCGRILMFLANSFPLGERSGVNLRGEFNVENVVKYDSEEELKDDPRLTDEQKTFYTLFWSTQSFLTNPPSIFADDNFQKFQKGVETTMSKFNDMSQREAVVAGSSADHAGKDSVSRKRSADEMDVDDSFTEEAVRDVYNEYFFPRFLTSRELLELELADISFRRTVLVQFLIALQYLDGYRSAEVEKTQAILAAKGGKPLAAQNLQKLTEEQESWISETRKEILKELQASNPHGREYTRIVELVLAHERNWILWKSASCPPFEMPPIEPNDFANLINSKRRKLTATLPPYRFEWGNSEITALYHRTLGRHLTDMMSELSDLPTALNYLNDVLPKLQNSKASVEARHEIANAVLFQVMRLLFLKEAHLVSKVFMAKKELMKVAREKAALAAKSSESGEVSEDVKAEDPSSITDKSVEFEIRVLQQAIKIISEDEEARRSNAAKAATNETSAPTQSSASPALSSPPKTTEIQDPKEGEVSKTTEGPASDREVPNSKPTQSAADEAGGQEITKSDPMEADPQPQSDLPAQEETQVEGEALKPKQEEGEMQLDTTNETQQSEVTNGIDNVAENITETVSAEEDRNVDAQNADISETTAEETVKGSAMEVDDIEAKIEDVATKEDQTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UPL4</accession>
    <name>A0A8H7UPL4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_002807</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ORC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UPL4"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000062">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="14">
        <location>
            <begin position="146"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6/ORC1-like ATPase lid" evidence="15">
        <location>
            <begin position="330"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6 C-terminal" evidence="13">
        <location>
            <begin position="419"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2186369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="523" mass="58721" checksum="287205EF3A26535D" modified="2022-01-19" version="1">MPKRRFHDRSNILPESSKRSARTKVVDYSESAATKKHRSQKHNETDHDESDYSHSSENEADTPRTPSKSFRSSTFATPTRKSLNLLGISPRRTPKKPVLTNRAIHRVNQYSQVVPLPQRSQETALATTAYEQARERLHVSAVPNSLPCRELEFEEIFSHVETALEEGTGTCIYISGVPGTGKTATILEVIRHLQHKSENENLTKFQFVEINGMKLTEPNQAYSILWECLQTPNEDQSVKKKRVTANHALDLLEQTYNTYDANRQPTQGCADGRTRPSGDKKANSHVQFLRVAKSSELKAHSRCRRQHNGFTRAHAEQQDFKSFRINFQPYTHQQLYQIVESRLEGIDAFEKEAVEFAARKVSAVSGDARRALDICRRAIEIVEENVKKGGAAAKKTHVTIAIINEAVREMFSSPAVTFVQQCSLHQKLFLVSVLKCVQRTGLADVEFGEVAQQHVQTCKWHHIEAPGTSDLMRVCESLGQTRALVVEGGRLDLGMRIALNISEGDLVMACKGDKLIGKLVSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCH3</accession>
    <name>A0A8H7PCH3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger protein 830</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Coiled-coil domain-containing protein 16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">INT43_002939</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCH3"/>
    <dbReference type="OrthoDB" id="77607at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059039">
        <property type="entry name" value="ZNF380_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040050">
        <property type="entry name" value="ZNF830-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23406">
        <property type="entry name" value="ZNF380_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="16">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="70"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2171317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="339" mass="38443" checksum="C7F3DB46B3E4B855" modified="2022-01-19" version="1">MPPKPDVRRLFNKSRTERKTTKQIQHPLAKYDTQGRLTCILCAIPIKSEAVWPSHLSSAAHKQTVAKLKQLKEAPQIRPKENISTGQRRTVSERESATTLVGYGGDSDEDDEEEDNEVTGQQAKRQRLEKEASSSEDDMDTDEQPQSNLPPAFFDQAPETSSEPAQDPPASENVDQGEENKLPAGFFDDPEADAKARNVLAPAEQQEADLDHEYELFKEAVAEDEQAATVNEVIDEEELWRDRDEDLERQQEELVARVGDLKRIRNEGGRGTISTNAPRASQFGEDDTNSRELKSSVRDFFKQAYNKKSVAAQRYDNFMDEDEESEDEDEDDWRAQQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCP0</accession>
    <name>A0A8H7PCP0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_009139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCP0"/>
    <dbReference type="OrthoDB" id="2313398at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="305" mass="34013" checksum="57D6B9A7D41ADDAF" modified="2022-01-19" version="1">MFTPLLPSALMCCPVELRDAILDQLPQSALLHLSATCRYFRQLILSRRQYWQIIELKTSRKDIQPAMLLHFLAALPSNSRAATTEIQIGQSLVRTLPDILVPLLHAFPNLATIDARSPQCLDLLGPLTVSLNGLVKSNMQTRYPKFQRLLLVDKSESRVMACEGSKTQFLARQLSSYLWALTSQGQHDMYVCEGCNEHLADIQYPSPRCAACDEPIIEQSCCLYCSFACEQCGDRFCGECDGRLTDSCVVCHEACPDAHQGFCTHCELDHECSSCHNKMCDAHTDTCMCGAIICSNEDGRCSECQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCZ6</accession>
    <name>A0A8H7PCZ6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCZ6"/>
    <dbReference type="OrthoDB" id="2411561at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="222" mass="24007" checksum="D5132549A4F8D3EF" modified="2022-01-19" version="1">MQKLENLQYVTTQKPNTSDDDTSTRTNVYVQNESKTNIHAQNFRHTSYENCTVTKPRQGKLFWSIIGVLTLLLAIFIALFVWAIATKPKADNAVNPTAVSPAAASSAANNTVATNPAAVNLTSYYLGPTDKVSMTYNSTNWNSWSTIESDTCITLTNASWELSISFVNKVALAKFFSSPTCANESYLGSCFVNTGITGHSNVIGVVTGNLNAMYVCGNTTAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD62</accession>
    <name>A0A8H7PD62_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD62"/>
    <dbReference type="OrthoDB" id="2385813at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="2">
        <location>
            <begin position="41"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="200" mass="21575" checksum="A650DC828192A34C" modified="2022-01-19" version="1">MLYPVKVMTAALAAESLATTNSAPTSNSNFGDSFGCSITLPSHNEQVSIGSTVLISWVVEPNALTDHANIEVDLLQLAKGREDVIGKIKSKISSDTRSIAWYIDNSIPVDDSYYIRISSHPSMKCYGPTFNIGKFHGDDIAKMAKKSSNQKSSIVVPAGDPQENLQVANQNTIASSSHRMDNNLTNLVAGLLVFGAFLWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD93</accession>
    <name>A0A8H7PD93_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adaptor protein Cbl EF hand-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000025">
        <property type="protein sequence ID" value="KAG2171241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD93"/>
    <dbReference type="OrthoDB" id="2227827at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014741">
        <property type="entry name" value="Adaptor_Cbl_EF_hand-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02761">
        <property type="entry name" value="Cbl_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adaptor protein Cbl EF hand-like" evidence="1">
        <location>
            <begin position="65"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="250" mass="29438" checksum="2DE9648B8D708731" modified="2022-01-19" version="1">MKSILKHIEESKVKSDEIVKNNIRAGQYRQFFKNKSKELSEGLVEMREDLDSIAPEPPSRLPLTAMIFWDNHFHNEKSIAWDYFVSHYTSENAITSMEMERKFKKFLCNIDDEYISIYTFYSTCSQFGYPIMLFIDNHVDTMKLAELIMSLTKELYSPEFGLHWGKLLELKDKAKINGKSNDKEIWLSILHQYRSKASQEMLDNVDIPGKARIYTFIEVCETIDEVNYNEILHLNANKSWDKGRPQVYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDE9</accession>
    <name>A0A8H7PDE9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">O-fucosyltransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDE9"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36050">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36050:SF1">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="48238" checksum="456441A14A169E7F" modified="2022-01-19" version="1">MTITVASPKYVLFLAIIFFFLFSLATFIWASTIAVYFRPIVKYDHNGEKFLAYLPHSGLSNQRNELENALMLAIYLNRTLIVPPAFLGKLPGWHPGNSMDQDMTRKTEPQSWWYRCNDKYAINDGPCNEKTDYLTVPWEFLHEDMIELDIPMRHIRHVSTKKIQKLLSLDDSEIYQQQDKSMYSWVLCDKPRDQCPPVRVGGGNKYDDQWVIEDLQKIPHTLIQLQGMFGSNRVGVSGQEHLELRTKVQEALTYKNPIIDAVTANIVNEMGGKHSYLAVHVRMGNRQFLGNLQNTIAQEIAFLEHELAKMECKQPSSTNCTSPLKIYLATDARNPRTNADLAPLFERFPDAAILDDFSHLLSPLEQAAEVAQPPQESVARFMLPIIESMVSAHAKAFMGTPGSTYSRYIARLHSVYQSSKYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDL9</accession>
    <name>A0A8H7PDL9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDL9"/>
    <dbReference type="OrthoDB" id="10423687at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034585417" evidence="2">
        <location>
            <begin position="24"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="329" mass="35290" checksum="ADD43D632475AFC8" modified="2022-01-19" version="1">MKSFWIQLAVAFTVALFQLGVQAGASEEAKNIAAFRGAQNFGKDEEDGSHYEKDDDESNKDHDDHHNHEKLDNDCEDALARCSVTVGINNYDIKIPCLQTNVINVKGYCPTDAGYGVLEIGTATLTVSAGATQMIASTEVCGSINTDTVSDFFTSTLTDTVTATDTVSDTITDIITDTITDTITDTVTQTQTLTDAILTTTTATVTSTPTPPIRDAGTCYKSNLAVNNVIGALLTRTYSYPQNSTTTGTNYAFTYDQCEDSCVAAPETTFKYFSLTQDKTTSTGQTKYYCSCYSKFTPGSGTGSCGAITVNGVPYTYGNANSEFVFELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PF60</accession>
    <name>A0A8H7PF60_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_000164</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PF60"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000010">
        <property type="entry name" value="Acetyl-CoA acetyltransferase (Thiolase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF8">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="13">
        <location>
            <begin position="31"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="14">
        <location>
            <begin position="295"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="11">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2172814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="416" mass="42935" checksum="257C5EAD2177FCC4" modified="2022-01-19" version="1">MATQRLQQVSAHLAPSLVSPSKIGVKSPEDVVVVSALRTPITRARKGGLKDTFPEEMLSAVFKATLEKTKLNPALVNDIAVGNVLPAGGGATAARMAALHAGFPDTTALNTVNRQCSSGLQACVQIATAIQSGLIEIGIGAGVESMTMNYGAGAMGSTSEKVSSECEAAADCLLPMGITSENVAKEFKISRQKQDAFAAASHQKAVAAQKAGLFDAEIVPVKVTVTDKEGNEKEVTIARDDGVRDGVTAESLAKLKPAFDDDGFTTAGNASQVSDGAAAVLLMKRKTAEKLGLPVIGKYITSAVAGVPPHIMGIGPAYAVPIAAERAGIKIADIDIVELNEAFASQAVYSAEKLNIPLEKINPKGGAIAFGHPLGCTGARQVATLLPELKRQGKKIGCTTMCIGTGMGMAAIWESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFD2</accession>
    <name>A0A8H7PFD2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sulfite efflux pump SSU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_000007</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFD2"/>
    <dbReference type="OrthoDB" id="1099at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000319">
        <property type="term" value="F:sulfite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09318">
        <property type="entry name" value="TDT_SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.150:FF:000004">
        <property type="entry name" value="Malic acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF1">
        <property type="entry name" value="SULFITE EFFLUX PUMP SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2172660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="42738" checksum="9A819B09D9A1F4BE" modified="2022-01-19" version="1">MRQTKLKSIILNFTPSWFSINMGTGILSILLMIAPHQFPGEKYIGIALYFINIALFLLFLCFTISRNIMFPWVLKLLLRHPTQCMFIGTLPMGLATIVNATLLIAVPKYGDWAIILSHVLWWIDVAITIVIVTAIPLLMFEAHKLTLQSMTAAWLLPVVPAVVAASSGALLATVLPVAQAKICIVVSYVLWGMGLGLATLILALYLHRITIHSLPNAEVIVSAFLPLGPMGQGSYGIVQLGKASKMVLSDSDMLHGTSTGEVIEIVTTLTGLLLWGFGLWWLCHGIFSVTIRALKNKMPFNMGFWGFIFPLGAYTSATIILAGQLNSAFLYILSLVFLICLVILYLVIMGLTLRNVFNATLFKAPCLADMDLSAPSQIENHNMDALDASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGK0</accession>
    <name>A0A8H7PGK0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGK0"/>
    <dbReference type="OrthoDB" id="2431262at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="163" mass="17148" checksum="E632B100D746EE37" modified="2022-01-19" version="1">MPGRDATQEKTKKSQQPSSEVESEAESEQQQQQQQSDNESVANTDMDQSQMGSDTESIVSEAPSQASRRRRNRRKNKSKSKSKGGPTDQVGDTANGVVDSVGNTANQVADTAGGVADTAGAVAGGGGGEGGDKPLRLRLDLNLDVEIELKARVHGDVTLALLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGW6</accession>
    <name>A0A8H7PGW6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IST1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_005177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGW6"/>
    <dbReference type="OrthoDB" id="29853at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.60:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein IST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.60">
        <property type="entry name" value="Vacuolar protein sorting-associated protein Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005061">
        <property type="entry name" value="Ist1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042277">
        <property type="entry name" value="IST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161">
        <property type="entry name" value="IST1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161:SF5">
        <property type="entry name" value="IST1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03398">
        <property type="entry name" value="Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2173757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32405" checksum="17273C7EDE9675C7" modified="2022-01-19" version="1" fragment="single">PVQRFCSPGKPSLFSPDSTMVFNPPRLKLQLKLASNRLKMLQAKKSSLNQKQRREIAGLLEKGKEDSARIRVENIIREDFETEAMEILELYCDLLSARFGILEQLKECDPSIETAVCGLIWATPRADQVKELAAIRDQLGAKYGKEFLVAAMENTNHVVNERLVSKLSIATPETFLVERYLEEIAKAYSVDWKSPNSQVESDNDGDNDALERAEYEHVLQDLKSSLDKESDDPTTTQDEDEFSDSKWDLPAPPSNVPGKSSGKPPSSTDQIPDFDELTRRFEALKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PH95</accession>
    <name>A0A8H7PH95_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_005068</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PH95"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
        <property type="entry name" value="SET-MYND_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF2">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="8">
        <location>
            <begin position="89"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2173650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="476" mass="52551" checksum="7020C3BFD63F7365" modified="2022-01-19" version="1">MPVYERASDAAELDSSIKHVRARLGPSHIALAPFLSTEPGSGYNDARLRSSLGKGREVAANATLGTGSQVLIEEPYAHEIGARWIGKICSYCFGDIPTVPCRQCNYHRYCSRACENNDWTRGYHSVLCSLYGVLNEDQILAIKAYLRSCASNSTKQLCFNNFANVQIPHLASNLADVPETDTQSYSSSAAFCAKALYLPASSVSCLVTIFAQIRCNRFAVKANTKSQSASIVTHVDETLGSAVYLQASMLNHSCQPNAFQQTKKSLSLTGHLLVAILDWIDNTNCKRNICFNANVRHVAKGCETDIIQRDVQICPSCGKAMDWEQIDTIEKQADQIKSGPCTLQQLKRVLKLQLAIYNPDALAIGSTYDNIAATYANTGDFATAATYCSQSLDIVRKQFGIESLESADELFKLATLLFNAMKPKEAYRSVLDCIALFRKLGLDKVRIDDMEELKGMRDALENSRGHWFTRTWKGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHV8</accession>
    <name>A0A8H7PHV8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_004168</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHV8"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="17"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2174148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="505" mass="54114" checksum="8795BA1B2C88AE1D" modified="2022-01-19" version="1" fragment="single">MSDSASSTPQYNTGDIAWTLTSTALVWLMIPGLGYFYSGMARSKNALSLIMLSAISIAVVSFQWWLWGYSLTFSRGANRFIGNLDNAFLRGVLGGPSIASSNVPDLVFCVFQCMFAAITPALAIGSAAERARILPTIIFIFIWSTIVYDPIACWTWNPAGWSAQMGGLDYAGGTPVHISSGFASLAYCVILGKRQGHGKEDFKPHNMSNVVLGTALLWFGWFGFNGGSALGGNMRAAMACVVTNLAASTAAITWMLLDYRYERKFSALGFCSGAVSGLVAITPASGYVGPAASVAIGFIGAIACNIAVKLKHRFNFDDALDVFAVHGIGGIVGNLLTGLFAEQYIAALDGSSIRGGWINHNWIQLAYQLADACAGATWSFGITFIILFIMDRIPGLSLRLDPEMELRGLDAAEIGEAAYYHVEKVIRVDPETNEPKVVEEIHQQLPSPNVNNISGAESTIGSAQVASVIDVDEHGQEHVRQFEQITSPTLAGGHFRQKAPSALNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHY3</accession>
    <name>A0A8H7PHY3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBM21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHY3"/>
    <dbReference type="OrthoDB" id="1881at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF36">
        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="172"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2174327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="439" mass="49294" checksum="0D51A00685D3C3C4" modified="2022-01-19" version="1">MPYTASQTLVINASSPSSKSLNTALPKQWTSNRRVSLKKNSLLNNRTLENAQEVCPLQDSVSPVKSSRTQQPGTGKLHLNLQSCTTPMIRKKSGEIVKSSLRCKSAPSTPTCPKFVHFNAELEHVRLFLKGQTPTSVHNDPQLPEDDENSSSSTDKDQLIMKLPNWPVLISPIEMLAKMVALESIQLAADQKSLIGRCQVSNISFKKQVIVRYTTNYWQDTHEVEASYREPCASGDASNSALDRFMFNIPIDPTINQNIFACVRYVVNGREFWDNNGGRNYRIDLYKPVTKPTIRQRVVSDELPIKRRTKAMDDTGLEFGTSPPNPITLAINENKSKLWDRYDFGASLSAAKKTTSPKYHRVQSYPSYFNDTPEVEDMIKPYQKNSNTTTPPIAIPRPQRPAPDSSSYFDLVNKYCFYGNESSIYSTSPSYSCSPAIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PI15</accession>
    <name>A0A8H7PI15_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF1793-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_005044</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PI15"/>
    <dbReference type="OrthoDB" id="3918848at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032515">
        <property type="entry name" value="DUF4964"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF1">
        <property type="entry name" value="GLUTAMINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16334">
        <property type="entry name" value="DUF4964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034950094" description="DUF1793-domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4964" evidence="2">
        <location>
            <begin position="25"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="4">
        <location>
            <begin position="106"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="3">
        <location>
            <begin position="337"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2173626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="856" mass="92691" checksum="97FDB1F83ECC30AD" modified="2022-01-19" version="1">MFKNTVVWFAFYSGLVASVSAVAQYASTIRGPAYPLAVRQPYVSTWLPANNLPGNWPTFWTGKVKGWEGIIRVDNTAYEFMGAASTNSNITGLKGATQKSVVTTPTQTIFTLTAGPVNVVVTFLSPVEYTDLQRQSIPLSYMLITAASNDGNSHTVQVYSDISGEWASNDVTQNINWSMTKDGNVNIWAAQMATQSQFAENSDYPTWGQAVLAAGTGAKYASGQDTVIRNQFISSGTLGNTNDGNFRCVQCDWPVFAFTYSLGTVTSTTSAAVEYVVGHVRPQNIKFLGTATNAYWMNYWSNANDMINFFYGDLSTAQSRANALDTKILTDAYNNGGQAHADILAFSLRQAYGATELSGSTSDPYAYLKEISSDGNVNTVDVMFPASPLYYYLQPAYLTYLMKPIFYQVENGYWSKPYSEHDVGSSYPVASGHADGNEEDMPLEESADMIFMVANYVFNPATSSANASAYAKAHYSTLSKWATYLYQNTLQPTNQLTTDDFIGTTTLNSGLALKGILAMGAFAKLAKLVGNTNDTSVYTTASQSYITEWIDLSQSSDKSHLMLEYIQDGYEFKYNALQDRLLKLGLIPASIYTEEANYYLTKETTYGIPFVSTHTYTKSDWEMWTAAAYGSANPTLSSHIIADLSKYLANTPSRVPFSDWYDCGTAATQGFTARPVVGGHFAVLAAEVSGSGTGTVYTPPTPVPAGTYDVTIGGGRSGCNQYLSSSSCGTDLVDMYGSDDGSGRQKWSLSLVSGKPNVYNIKVSGGRSGCDTFLSSASCGSDLVDLYGSDDGSGRQQWLVVPVPGVSNQYNIMVNGGRATCNLYLSTASCSNSSNLVDLFGEDDGSGRQRWVLKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PI37</accession>
    <name>A0A8H7PI37_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_004274</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PI37"/>
    <dbReference type="OrthoDB" id="2351920at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008401">
        <property type="entry name" value="Apc13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05839">
        <property type="entry name" value="Apc13p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2174253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="75" mass="8622" checksum="8852D00E124C5B8A" modified="2022-01-19" version="1">MDSQFTHIHWATSRLAILSDEWIGERLPEETVEVPKEHQLAPDEDGDICKQYWAPDSGNAYFQQQKEAEKAYVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIN5</accession>
    <name>A0A8H7PIN5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Regulatory particle non-ATPase 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_005841</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIN5"/>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13314">
        <property type="entry name" value="PH_Rpn13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032368">
        <property type="entry name" value="RPN13_DEUBAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16550">
        <property type="entry name" value="RPN13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="8">
        <location>
            <begin position="29"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="DEUBAD" evidence="7">
        <location>
            <begin position="291"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="220"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2174779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="45549" checksum="3086CA00F7F79CEA" modified="2022-01-19" version="1" fragment="single">PPFDGHRSTCGINQYCNQIMSMSLFPTPQRARHLIEFNAGKCIRDGNMLKPDLRKGVIYMDQVRLTDIFFDDNNMMTTIESQIMSEDQLMHFYWKERVGSTIEDDLIIFPEEAEMKKVPECTTGRIYILQFKSSNQKLFFWMQDKDDAKDEERVAKVNRLISDPQSVIEEQQRNAQTDMEEESESAADMLNLLSGGQDLGINQEQFLQFLQTAGGLGGTIPNSSPIGGDGPPASQNVITSASNSRRASRETEREEPQPEQSSTESSNNSDLSSDQLNNLRNILSDIRIPPGQDQNSSLDLSSVLTPEAVRSLLNDREVASALFPHLPEGSEHSTEELQEIMRSPQFRQSLHRLSVALQSGQLGPLMTQLGLDPSAGNVLPGVEAFLAAIEEQARRNDDQDHEAMDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIS9</accession>
    <name>A0A8H7PIS9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIS9"/>
    <dbReference type="OrthoDB" id="2421121at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="646"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="692"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2174334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="835" mass="93255" checksum="0CE69F629E445768" modified="2022-01-19" version="1">MVPIEWPNSDSAPGAEDSNLRELLQRQANVQLGEVHDKTIIEWIQLSHEYLRDFEEALLRNDQLHAYASFVVATRICYTLIPAHPNYANLSRSERMCDDLLRQKILDNFPEFMRLTVPSIIDRETSHLGVASLSSRRTDRLTPPASPASSTVASIENDHQSFITSDPFLQQYRSDQQSIISADTFVRQQRSIATEKPFATDWDVSANERKQPPPENSLNRDKLLQRHDNENGMTVEDRVIIDDSSVTALRGTLFENLGPESSLHTYQTSSSVAPRIDTPNESDKFRVGHGRYPSASDTMAELYQKINETKISWKNHDTSSISSDDDVDQEPSNIIESSHLFVSNGNIPFTRVGFRDDDTTGIASPTMKNKSKDLYLAQNQARLSDDKIPTMITTTTSTPNSEIFPMDSISRASSISQRGGLVASNEEPLATDFEHLRLTNSNSSHVLQPLEPITLTPQLDDTTINKPDENDGSRTTVTTTTQKPDDVMASNVSTAATAPSIANSDSFDSTHTLRRKSFVDGFWGSKQPKKETSRKKITVQQPPPSSYVQGSTSYYSPFRSIMSSGKSKGKAKKSSKDVSRKESKILQPAVRQAESNHAAEQVENHSLSQPVDKSFERKNRDSISDDDVLPSDTDDRIAASSAHRPSTSSDMTTGSSSVHESSSSHPIPITSQHPSWAENISANVYQGEGILSSSPASYPSTSRAYSSPQSNTLTDFQTPAISPTAHPLIKRLQRYAHTSLECVKYMDFSSLISYANALFAGMRQLESERDYEDAYVQGYMGIIVVTNVLCKHSDRRREKELDFYRFIEISELVNERYKSKLNNIQNILENTHPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIT6</accession>
    <name>A0A8H7PIT6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_005916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIT6"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2174854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="89" mass="7948" checksum="336CD7F4817B6B88" modified="2022-01-19" version="1">MSEASKSAAAGVASSGGATMASASGSAMMTGSSAMPTAGANATSAGASSAGASASASGSGSTSGSQRTYQVASALTVGAGLFAVVMANM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKI5</accession>
    <name>A0A8H7PKI5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKI5"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03139">
        <property type="entry name" value="GATase1_PfpI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF15">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="78"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="238" mass="25878" checksum="B4B0E441BDB94E69" modified="2022-01-19" version="1">MTQETPTTFGYLLYPGFALLDVCGPLEIFNALSALVSIQMSLIALDSLEPVSTCVSPDSIPGFKGSSMEKMLPMNTLEQKITPTHTLDTVPELDVLIIPGGFGGLAASQNPKVLNFIKSTKARHILTVCNGSPVLAATGLLDGHKATTNKWLYETLVASRPQVNWVAKARWVHDGRFWTSSGVSAGMDLASAYVREIYGEKIGELVTDIIEYTPELNPDNDPFCGVYKKYPPEALQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLE8</accession>
    <name>A0A8H7PLE8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_005436</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051139">
        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041285">
        <property type="entry name" value="MID_MedPIWI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
        <property type="entry name" value="Med13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18296">
        <property type="entry name" value="MID_MedPIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MID" evidence="14">
        <location>
            <begin position="1166"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit Med13 C-terminal" evidence="13">
        <location>
            <begin position="1361"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="614"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="796"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="859"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1503"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="812"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="873"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1513"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1536"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2176202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1684" mass="186358" checksum="393E787BA26826F8" modified="2022-01-19" version="1" fragment="single">DDDAQNVDSDNEIDDNVTAELWVFWMDDKHTGIVDRNVFLEQLEEVRVGSFSWENIFLNDPSPTASPISPVAKANAPPNTSLSQEYRFFIKAVRNIIALKMVQKGSIPLGDFFIYQPSAKSSVMDDIIPSDQKVDSPKIISERTCPSCTFNLYLTSTNLVFQPVIQRLRLRLLRRTDFKPDDLKTGTISATLKSVTTDLSTKSEEAILMDWADTLDIPAEVLKGQREMQANMPALVLVQIGEEVVPYPSVLIFISTSTKATPSSVAGLDGIGARNHGFIEEMSEKYSRWAWEERIAEIAIKTGAEEAFGTGSLNKSNSQKRLDGHIETGTSTIHTLPTPVEYAAQSGHSSEVEHQLASQPRFTVDFWKFTNPTAHVTSTVLKHASMPDPFGSPTLLQNAMMETLSSTLLVTPKMSRTPRRITGGYSSGALQPTISHSWDMRRQNSKDFLSGIDLGQNPVGRKSEPEDEAYHGVTQYPYAAPSGTHDFKPEELSYANASMTDAQPKTNVDRGDLSGLQITMNEQPNSNVAGGHFQDTNQNIPMNVGNNDPQDESNFPSPQDHLGGGNVDLAFGMENLGGYDQMVYGMSSGWEEGVGDLENFDLDVTEEDFDFFESTPTSKARPGTEVVSNPVGPPQASLATSSAAPVTTLPANALDAPIMTDLSMAVNDMDKQNNLDLDELLMATNGFLDEPLKTEPGINMTQDIVPSEHTTVPIKQEERLDDGGILDGSLIPDVKGIKASQDETGHTIEDVNQLEVHEDTILDADAIMPPEFAPLSVNASVNDAKYYEGGKFVYSPSKKRKKESGSARRTVYKPDYKPSTRKKLVDHGTKLQMRNKYYSEPKKIDHIISATAPMKHNFTDVNSNKTSHPPILSDGSDGSSSSSSDSSSDSSDTEMEDAEDIVRATSRLEIGTDRQWSMTMNKIRTALLVWNAGGKTGNGFPLFKQAKLPLGRVIDYDVPFAEIIMREPMYERPKAQHTADGHRAAVELLCQQAVLGGYPFIGNIAEISQRGGEFIDGESMEVTITRRRNLVQSNCGAVLSVPALSDESDHLILDFKDMLNSIFDVNNTSDNPEYTHLQIGQHTLPTAVSIKGPLNIQQYYELSDTTQTQSKYGKYQVKKRKPVEPNLDALHAPDVVVGRQEEWIEGSPHILPFWEKLRLEPYSTKKNVVYFVLCPESEGLENMAANFFKELSAVYEVCLLGTHHSGVAGDHRKGVIPISLLDKFEHESIAEQRMRSYKHAAQRLGATIGNLGLEGVYYVIYMINPFSHSSSLLDLSQCFQNLVVAFNTSNLGTTFSDKTRPRIVMQLIPIEHILRPVAFGGYTKFGLKEIAFSVYSKCHVIVERSHQQSRVDDMQAVTELYAPPFILAKPPPTTIQYSIKNAFTSFPSSLEHDVTMHVAYTFSLDNRWLIAIWTDARGEMVDFMVLQIDGHLNKSDWRTNAIKDIWERTKHICGRAGFSWRYTIGKLGLMFGEELADWVATVNNVENVAIVALDCDSPFRVSHEQESTNGIESGNTPSSSSGTPTPETFTPGATPISMNTINTSGTSKSNEVFEPETGESYALLVNHRVAYSHRRQLASHGILLNQDMPLTEEWMLPLASAYLLQVPVKTSAPSREHLSLETQAIEVHLIHLQSSQTASSVIRDIVKQYHAVSYLNTVSATSNCIPLHFNLADRLCRLLYAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLF3</accession>
    <name>A0A8H7PLF3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_001028</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLF3"/>
    <dbReference type="OrthoDB" id="1939598at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="196"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="103"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="166"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2175381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="277" mass="30780" checksum="8E503D05C2B9648D" modified="2022-01-19" version="1">MSYDQYSYINSLNTLSGDNSADLSGPSEQELADELALWSNAQFTFDIEPGVGIYEDKPLEYDSAQLEQKNLSELTTASKNDMSPVTYEGLANYLDYELPTQQRSLAPNPAPQQLLQPRPPVTKPSMPVLAPRLAPAPPTDGSAPFNGANFPSGFGVPMIYPKSEEKPVTAGVKRKAETAKPVDDSISTDPSLDSKSATEEDKRRRNTAASARFRIKKKQREQALEQTAKEMTDKADRLEGRVKELELEIKWLRSILIEKDARSLDASDEQKQELKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLI9</accession>
    <name>A0A8H7PLI9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_001316</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLI9"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000085">
        <property type="entry name" value="Putative ras-related protein rab-11a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2175669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="237" mass="26508" checksum="CB3490D87FF025BA" modified="2022-01-19" version="1">MAPESRSRKSRSCHQIHILDPLPPSEMSRDDEYDYLFKVVLIGDSGVGKTNLLSRFTRNEFNLESKSTIGVEFATRSIQVDSKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHSTYENVTRWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEAKQFAADNGLSFIETSALDSSNVELSFQRILTEIYRIVSNKALESSNDVIRPTGGETIVVSQSPDDQNKGGKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLQ2</accession>
    <name>A0A8H7PLQ2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLQ2"/>
    <dbReference type="OrthoDB" id="2361284at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="451" mass="50659" checksum="C734B3F39B12511C" modified="2022-01-19" version="1">MMCRSPSLHYATSQLSNDFQSTEHRYANDKQHAMLHRVLELVEDLSARVDSMQSSKSERPPVDIFKPLPQVRYSGISVSGIVKEEDSSPLPARHSLKSKQTLSDAHFTMKKEFKVDQVLDPLHPDVHANYIKVLESFSHEVLPDNLSWSANTSNDRISDSNGHQVDLRSRYAQAYLLLQCTQAAVRSPQKIDSLINAVNSIALYEMQRVVDIQNEFPYKMLPSDIESNPHRQRDSSSTISSSFSQEKAHAPLFLRSSGQQSMESIELQPIANDPTDPAYMPLLEYKVQLMQSPSVPCFKTAGYIEDLNTPVFDHTDGEQQPYAIKKCQSALELTSFASFHGDDAFKLAPIDHSEDVVSDFFESGFDEQVKTPMVLCEAFEEPVERRNASEFLFALPRSQSSISSFRPISKSLSSVRLTKSNPGTKNPKFVRSLVKKKESFAKLFAGASGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLV6</accession>
    <name>A0A8H7PLV6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">60S acidic ribosomal protein P2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_005622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLV6"/>
    <dbReference type="OrthoDB" id="1227494at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001859">
        <property type="entry name" value="Ribosomal_P1/P2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00456">
        <property type="entry name" value="RIBOSOMALP2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2176388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="11019" checksum="ADBD61F1B72C80A0" modified="2022-01-19" version="1">MKYLAAYLLLRAGGKDAPAAEDVKSLFESVGIEADSDRLNSLISALEGKNVDEIIAEGKEKLASVPSGGAAAAAGGAGASAAAADAPAAEEKEEEKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PM09</accession>
    <name>A0A8H7PM09_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_005449</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PM09"/>
    <dbReference type="OrthoDB" id="2162691at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="775"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="8">
        <location>
            <begin position="534"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="180"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="397"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="703"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="841"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="397"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="467"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="500"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="708"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="718"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="841"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="861"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2176215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="900" mass="99377" checksum="4BE613ED7F0F03FC" modified="2022-01-19" version="1">MANESDNSFLTSVITAASTTASSLATNLSDRLKDPSPEINPDASSGEEIMQKPRSQTPDPAKPDTAMNVQKRNSGRIHSHTISGDRPPIIITNPRFMPSPQRRNSDGGSPRPPLPTALGDDLQPAAPVAPTTATTEAAAIFSSTAPSLSLEHLVNTSKPISDAGSVHSVASDSALMNEAKTPIADPETPVTKDMLLVPKKRGRARGSSVSTAHSDSKSVSLSRTNSVSSRKATSTRRKDSDDTEGEAGSDVASAATGSIASACGMDLANAKRNSDYHALFRSVPEDDVLIEDYGCALQKEILVQGRMYISETYVCFNANIFGWVTNLVIAFTEIVAIEKRMTAKFIPNAIQISTLHSKHLFASFLSRDQAYDQLVEIWHVAHPNLNGRSLKKIDGLEDENDEEENDSDSYSDETDDSDSEYDSDEYTEVSEDEDEEAEDEGEITEDGKHAPDRQASVHTLPLPAAKETLEQENRRRAVSEVTPRPDAKDLLKPKADGSKPGSSAEDSGVEQTKASAKAVKHAPTECECAKNDEHFSQVGLDETYTGTLETIYNLLYNSGFRKKFLEEKEKSTDVNIGNWEKGSGDIKLAREITYIKYLGGSIGPKSTKCILKEEVLHCDYDDYISQLTTTQTPDVPSGSSFCVKTRTCLTWAGDNKVRMYVTFQVEFSKSSWLKSTIEKASTDGQLAHYKLLDESVRKYIKQHPNEFGGDKNADKGERKKKKKRRRREPKKKDQENADAANHNKGTLHKLISPFLFIGGLLWSGIKFVIEHVQIPTAQHMTMLFMLFMLVLSLLAAQKMADMERQLELLTSQIQGFPSQGVWIGERERDQVWQWLLNKDKDGSTSEHHATPLEASEADRSAWNTATSSNVHNKQDLDHELAQLGIRVQEAQHRLQKMSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PML1</accession>
    <name>A0A8H7PML1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar segregation protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PML1"/>
    <dbReference type="OrthoDB" id="1204at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010513">
        <property type="term" value="P:positive regulation of phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903778">
        <property type="term" value="P:protein localization to vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024260">
        <property type="entry name" value="Vac7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258:SF1">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12751">
        <property type="entry name" value="Vac7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2176984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="57228" checksum="38166FBE531D38E0" modified="2022-01-19" version="1">MSDSDNPSNPPVPAVLVENTDTDGQGDHSDVNASNTESNLVGGSRPRLKRSYSKNLNSPSDGRKFHTIHSSDGAKFFNLENQLRELQGTNKGDANNTGSERQLTVETAIYRDQPMFSESRRPLLPTEMRSIRSGTESTRSTKRKKRPGINTAATPAQIFAQNLSDAVLDAEDSDEHESFVYRDKTISSTKSINPNLTWSSFEAPGTDFYQSSAPRIPNYISARASESDLFREQKLREDHESHRPALRSSVSDLPYHFGRQRNFGQSEWYPSDEESAPLLQNAYARKHKTAEQHSRKMMLSIGMLCIMMFGMAALLITAASPLSDIEVTNIGNVLSSQKELIFDLHVQASNRNWWTVKMVHADISIFASSHFVPLSVQTNNQTNATQVVKTSSLGQAADPAEFLGSIYHFDEPLLFQPAGLFESQVTTSVSQVQIKQPGHTDDGDSGNERWSRLIRYPYELTVRGVLKYRIVPYFTFTSVHTSRVCNVVSVDPSTGKVTDPPPNDKAICKTVRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMX3</accession>
    <name>A0A8H7PMX3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutamate--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_007626</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMX3"/>
    <dbReference type="OrthoDB" id="428822at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000045">
        <property type="entry name" value="Glutamate--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="An anticodon-binding domain of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="12">
        <location>
            <begin position="569"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2176972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="731" mass="82084" checksum="C7BB01145A051C68" modified="2022-01-19" version="1">MLRLVRPRPILLAPCRLQVQRSVHVAAKEPIAPVRVRFAPSPTGNLHLGGLRTALLNYLLARKTHGTMILRIEDTDRNRLVPGSVNMLVNALQWAGIDYEEGPSKGGPHAPYAQSERTEIYRSHADQLLENGSAYRCFCSQERLKSVRERSAKAGKPMAYDRHCLSLSKEEIDGSLKANKPFTIRLNTPEGTTVVHDQVYGKVEFNNRTIDDAVLMKSDGFPTYHLANVIDDHLMDITHVLRGEEWLPSTPKHLMLYKAFGWTAPNFVHLPLLLNADKSKLSKRSGDVHLEDYIRRGYLPEAVMNFVALLGWHPNTDQEIFDSKELIEAFSLAQLNNSNAIVTLDKLDWINKQHLLRRASTPTGLQSLVDMLQPIVNATFGKSLVDSQMEYRMKPEYLTGVISTIKDRIRNIQDITNLCSYFFVEPDWKTPEAETFQKKLNKQALSATLSTEYFNGLSNLDNFNANDIKQYIHEFADQHQLKANHVMMATRYAITATKVGAGVADTMEFFRLVTHFTSDNCFSTVKHSSIPLDSVEMSSAYGTIAKPETNGSLESVLPIHETLRNGSNMVVEAVDPNNEPLVQYMHKIFNAEIEDGYDSFIAVKNGPLQPDTDIEQSVMGMFYIKPNYPGRCSHICNGGFFTAPAHRGNGIGKAMAKAFVKIVPVLGYKASVFNLVFANNPASIRIWKELKFQEVGRIPQAGSKLVRLKNSPDALVDAIIFYKDFTKPEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMX9</accession>
    <name>A0A8H7PMX9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_007597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMX9"/>
    <dbReference type="OrthoDB" id="3202396at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025444">
        <property type="entry name" value="Monooxy_af470"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13826">
        <property type="entry name" value="Monooxy_af470-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2176943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="308" mass="33169" checksum="5C018BE79E08B179" modified="2022-01-19" version="1">MYAKLSQSESEKVSASGKTIFGVHQASDSGVALVGLFGSKALLGGAILATSILPRYLAALAGGLILVSAYRNAVSFSLKKFLFPPKPQAKPTKEELRHINLDVNSTEPINFRVAPVIEGDFVVFLIGARVNEFSKDSGGNWIGDAMSAMLKELQDAPELGCLNADSYVSTNPVGGSTFLLVQYWRSYEQLADYARGKDNEHYPAWMRIIKHAREGGAKAGIWHETYKVRAGEYEGIYINTPPFGLGKVGLVPAVGHMTTSKGRAGMTDGTDYLEGTEDAYDSLNKADLKVSQKCPMSGAQRGTCPVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PN02</accession>
    <name>A0A8H7PN02_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">PLAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_007671</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PN02"/>
    <dbReference type="OrthoDB" id="10072614at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="15">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="5"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2177017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="254" mass="29582" checksum="B1B505138F362711" modified="2022-01-19" version="1" fragment="single">ERIRVEGLKRQAEEQEAICKQWIQAAMVDYPDRVETNKSQEQLEKEIKYLETRKTEQENNCGASLEDVQEEAKKALKAWDDARKTVDELEVFVKTMTKALHDRMEKWQRFLMYISLRAKSYFIYYMHRRGDSGKLNFNHRKQRLEVQVSTGDQFQKGTRHKDSKSLSGGEKSFSQISLLLSLWQGIGSPIFCLDEFDVYMDAVNRKQSMRMMIEAARENAAQYILITPQDASSIAIGSDVMIHRLADPERSDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNK4</accession>
    <name>A0A8H7PNK4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-specific glutamate dehydrogenase</fullName>
            <ecNumber evidence="4">1.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_007759</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.2" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNK4"/>
    <dbReference type="OrthoDB" id="184415at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056365">
        <property type="entry name" value="NAD-GDH_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016210">
        <property type="entry name" value="NAD-GDH_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055480">
        <property type="entry name" value="NAD-GDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF24">
        <property type="entry name" value="NAD-SPECIFIC GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23147">
        <property type="entry name" value="GDH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23152">
        <property type="entry name" value="GDH_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000184">
        <property type="entry name" value="GDH_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="5">
        <location>
            <begin position="663"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2177103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1030" mass="116984" checksum="3284225ED626A791" modified="2022-01-19" version="1">MTVANNQAAAERLLVPDMVDKSHTVKNVSGYTANVFPGKQEQMVSVCEYLSGVGFLPKDLVQNEVSWFYGNLGIDDYYFALETVDTIANHIMALYGAKILAFTRHESVLDINLERETEDATVYIHSSKPGVSQLSGPKYEKRIDEKFLDASVRSLAYRLESYRSNGTVSSSLTSQLRCYFVTKCQFVNENPTPEQETDIKQVADITFLKKATDHTLQVYEEVMNNVLQRTGPVIEMYQVEGSREHRLVIGYRQRSTQNFFSAMSDLYHYYDLYSTRKYVEQFSNGVSIMSLYLNPVPNARGFPIEHSIHQVIKETSLIYCLPNTPLQSFFQSNQLSVQETVYGYVGWIFCQHFLNRLGSEYLGLTTILDRSNPTHEEVLNKVKKRLRQETFTREYILDIISQYPELIKVLYANFATIHYVNQREASLQPTLSYQRLSTQEILSEAQLRDKIKHTTSNAHEQMVLESFLTFNKHVLKTNFYQSTKVALSFRMDPSFLPEIEYPNKVYGMFLVVGSEFRGFHVRFRDVARGGIRIIKSRNTEAYSINQRTLFDENYALAATQQRKNKDIPEGGSKGTILLDIDQQDKPRVAFEKYVDSVLDLLIIGKTPGIKETLVDLYNKPEILFFGPDEGTADYMDWASAHARRRNASFWKAFTTGKSQSLGGIPHDLFGMTTRSVHQYVLGIYRKLGLREEECTKLQTGGPDGDLGSNEIKISKDKTLAIVDGSGVLYDADGINREELTRLANARLMISNFNPEKLGKNGFKILVDENNVKLPNGMVVDNGLQFRNTFHVNKLSSAMIFVPCGGRPESVDLGNVNKLLGEDGVPRFKYVVEGANLFFTQEARLRLEKNGVVIFKDASANKGGVTSSSLEVLAALAFNNEEFEEHMCVRDGKVPAFYEAYVQEVQKIIERNAALEFEALWREHHKSKAPLSILSDDLSVAIVQLNEQLQHNSLWNDIELRRHVLEAAFPKLLLDKLGLDTLLQRIPESYVRAIFGASLASQFVYKYGPSPSQFAFFEFMNTFASSIAKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNV3</accession>
    <name>A0A8H7PNV3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_007895</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNV3"/>
    <dbReference type="OrthoDB" id="1713558at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="247"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2177238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="498" mass="57651" checksum="88B7C55EE6A47BA9" modified="2022-01-19" version="1">MSKEQEKSENVAAMEVEESEEAKQERLQQEATALAIADIKNNFVFLERAVDTIESRFTTRVLRTTTSIRKRLTPYILSQVINEYYADDTRKNDLLRYLGEQQDVAMKDTAADESKKEIPRLPEIDIYLHLLVMIYLLDNQKFEQGMELSKTTVQEVETLNRRTMDQLTAKAYFYYVRYHELTDKLAEIRPILLAAQRTATLRRDDDTQATLLNLLLRNYFHYNLYEQADKLVSKSTFPENASNNQAARYAYYLGRIRALQLDYTAAHTQLLQAIRKAPQNTATAGFQQTAYKFFIIVQLLMGEIPERSIFRQPVLRKALLPYLHITQAVRVGDLNKFQEGLAKYGANFKRDKTYTLILRLRHNVIKTGIRMISLSYSRISLRDICIKLHLDGEEDAEFIVAKSIKDGVIDAVLDHDGGYMRSKETADVYSTNEPQSAFHQRISFCLNLHNESIKAMRFPLNAHRKELDNVQEALERERELAQEIAEGDLDDDDDMGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPU8</accession>
    <name>A0A8H7PPU8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_003128</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPU8"/>
    <dbReference type="OrthoDB" id="5569911at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056703">
        <property type="entry name" value="DUF7801"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029191">
        <property type="entry name" value="Uds1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25078">
        <property type="entry name" value="DUF7801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15456">
        <property type="entry name" value="Uds1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="75"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="272"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="607"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="666"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="911"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="369"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2177881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1226" mass="140924" checksum="7A8D083290BDED4A" modified="2022-01-19" version="1">MFSIRRLITSSGSCRTIQNAYSLRRAGFSTSTTIRQEVSELSSQKLSNAPPKPLPANYRPLQVLNRSIPKEPFTELVSLQNLPDTATKEDILRLARQAFHDAEAPIKEILFVRNQELQFNGRVLVVFENAKDAEHFRLMNDHVIVGGNQVKVNRVDTKNLSSNDLLKGFRKSEMYSANGKTAAGRTVILSGFPQRTNTSHVSRWLHSKGYYPEDDEENAIIQAPTKQQALVSKFFIRFPSESDAWRAVRRFHNVTFRPNTFNNRYTIKATTYMNPSYSRGQNSDKDKPRPLTSSRSQLSPTRTTFPMSNPLRSNTVNRPGPGTLNAQRTSENSSASQIGFSYATVIEPSSGNNSNIRVASPTYGSPTYSDERSTRTSLDLRDRPQPPIQQQSSRSSLDIPPLWKSMRETVIREEEQPRPPSMDSTEDYLVQLLVQQSVIDAKDFEVLTLEQVEELKKDHVSLSSRIANVTTRLALESKMREAAQSLTHLHSSNRKMAQQAQNQLAAANRQVDHVASELFKLTQSGSNVQRKLLEHMAGALSVGIKRLEMQTANSQQPNHQGMNQELTSMAKKLQERDAAIADRDREIERLRMQVRAQTMDESAEAVIEQRERIIAELRSELEQVTNRLDFITRRESLLSTESQDRAFPKNDHNRSDDHPKDTAAISVQLEKMVSALEDRLVEYRQNSTRLEVELEEMEQQRNELLQSAKGYESKPDQAAYEALRLKLEDEQQARSETENKCNELNEKIRVLESLKRESESNGASSEELLKLSAEVEKLERHQRERETELENNLSDARETIQRLKVAQSALAVEIMAADNMSDNEFDLEECRLCIRELKSQAERVNADVSSFEKSLSDSKLREELLEREKDSLVQETARLRAKMSDMEVKSNTSNSVATAASARERSLQMELQQFRAETFELREQKEKWEKTMKRESVFQVVQGGGDSLKAQFEQAMQEQVEEYEAQLKEQSALLDKTMREKDDLESEKQKLTAMSKDLEDLVKEKIRTLDSKEGVIERLEMELAEVKVRLVESQTSGYSEIDPSVLNELSTLRMENTTMEAELNITQDQLHALQSRFENAQRQFTKVEEELHRRSERLEDDFEGIMKEYERITQNLINLESERHSYDRRFNETQQRALHLETELADEKIKTMGMGEINESSTTASLRKEFRRLLNEMKSEHHEVLMREVLERKKLEGTVRDMRRDEEMRRWDKVSKGVQTNLVLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQ14</accession>
    <name>A0A8H7PQ14_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007838</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQ14"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="189"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="262"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2177181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="413" mass="47261" checksum="910CFFB8B2883ECD" modified="2022-01-19" version="1">MQYQTCPNPAITGNFQWQKTALDNSQLNWDLDESQIRPDYNTSTDTDSHQLDRSYSSDSTFSFHNDTSLEATYNEQKIKGEENGLSPSQFDPDNYFPPNKKRCRPDFEQNAQDPFDMCPSIVIPSSPQNRSMKTTPSSGVFSQPITPIDSPQDLSYTMLVQDALACFQPKPVNDGYFPTDQDIEPHNKVNRLAHNAIERRYRNNINDCLNELKNAVPALKFAKVKDQNIDDTRSCVNDGMDNFEELIDGVPVATKLNKATILRKATEYITHLKATLEQSESENLALQNLILQLPRGQEVVSYYRMQKQQFQVAEQERMAIERQAAFERRQREKREARRRSKMLRRGQSSTESRRNSSSSNSSTGHTFMALFLGLTYFSTTTFSTVQNTSESAHHPIGSSLYAFQSYDIWYVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQ83</accession>
    <name>A0A8H7PQ83_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_003172</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQ83"/>
    <dbReference type="OrthoDB" id="10249382at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000003">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000012">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="10">
        <location>
            <begin position="48"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="11">
        <location>
            <begin position="249"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2177925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="478" mass="53959" checksum="0693708B2FCA656F" modified="2022-01-19" version="1">MPREIITLQAGQCGNQIGSEFWRQLCAEHGISSDGTLEDFATEGGDRKDVFFYQADDDHYIPRAILLDLEPRVVNNIRSSAFANLYNPENIFVSNDGGGAGNIWAHGYAQGEKICEEIMDMVDREADGSDSLEGFMLLHSIAGGTGSGMGSFLLERLNDRYPKKLIQTYSVFPNSEEVSDIVVQPYNSILSLKRLANNADSVVVLDNAALARIATDRLHIQTPTFEQTNQLVSTVMSASTTTLRYPGYMNNDLVGMISSLIPTPQCHFLTTAYTPFSSDQVDKAKSIRKTTVLDVMRRLLQPKNRMVSTIPSKRSCYISVLNIIQGEADPTDVHKSLLRIRERRLAQFIPWGPASIQVALTKKSPYVQTSHRVSGLMLANHTSIASLFRRTCDQYDKFRKRNAFLEQYRKEPMFSDTLDEFDDSRQVVQDLIEEYEACETPEYVNHVSYLFYRCWLAHSYLHKPTLSGPKRYANSLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRQ4</accession>
    <name>A0A8H7PRQ4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_001891</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRQ4"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000333">
        <property type="term" value="C:telomerase catalytic core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01648">
        <property type="entry name" value="TERT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066:SF0">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01365">
        <property type="entry name" value="TELOMERASERT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0158">Chromosome</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0779">Telomere</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="535"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2179042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1047" mass="120189" checksum="E0033E57E41CB322" modified="2022-01-19" version="1">MNPQECAVLKSLFTKTVSLRTYICQHRACRAGITDKLKNASTRLQELLDTALATHTPSIEKGRDIEYSRDNRFTSEDMWWDRNNSLIKQDEVRTVIHELHIAAEPMPVPHHVPACLDDVFLPNKRMSCCAATMPTKSSYLPTQKVDGVKKRKRSRSQKSKIKSNLQSSADFMNAVFEKENRNISHAKSCRRQRKRQRTSSMKNSTSSHVMVCDSVNDKDTPPGMTITSAKRTHTEAEISCKKGKSDVEQAKRMKSLSNVSASTRLLKRCLMFYGEPKANQQNQISMKLPRNYMLTLPVSKLRNAASSRSRNHVLSSAALDVLLTYIFPKQYRKPNILQGTVTEPATLQRKNPFFVMKPYYRKWRLPPRLQHFKNYFAIICQQHSKMDYKRILDRVCPTKHSGSGADQFSSHAQVCAFVLQCLKEIFPYGIWGSQENFRTISKGKLTDLNKHLLSLLVLMLQMLAVYTYVSLRKFETLSLAQLMRSFKHPSSAVRNAEKRRDNERVSVLAVSVLYNTSPLDVWHDISQPAVSRLISVNFTTFDASKFEFSCLRLLPKGANVRPITNMKRRFQKDANGSQIEQTAHKSANNVLANALRALTFEKEEIPELLGSSIMSFEEFYKTLANYKEWYLSTEKTNSERPNLYFAKVDIKSCFDSIEQDVLLGILDKILSQDEYIIKRYSTMFATTGGKIHFRHKTYAQNADDYDSFQTQALKMSETLPNTIFVDNVLHKFEDRDELLELIRRHIKCNVVKIGSGFYRQTVGIPQGSCLSTMLCSYFYGSMENEELSFLKNDQNALLMRFVDDFICISPNKATVQKFTTTMHKGSIKYGCFVSHAKSLVNFDMMYNGVSVAKLENTFEFPWCGFLIDTRDLEVYSNYQQYFTCHLQDTLTTEFNKHPGLTLVHKGMLTMKPKLRPVFVSKMFNRPETISRNIFEAFLLCAFKLCASASILKYTGVAYLDEQFLLKAIWHIVLTTTHLVKRKLSSLSVIWLGLHAFHLALKRKSRLAPKCQSALEAQLSHDIMQHTGKNLLPLVGTHLRYPFTKIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSS2</accession>
    <name>A0A8H7PSS2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_001950</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSS2"/>
    <dbReference type="OrthoDB" id="18884at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.860:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03000">
        <property type="entry name" value="eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027512">
        <property type="entry name" value="EIF3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054711">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22591">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="317"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="845"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="671"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="609"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="845"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="905"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="963"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="989"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2179100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1045" mass="119726" checksum="079C8302C7DC6B15" modified="2022-01-19" version="1" fragment="single">MQYGGSGNANALKRAEELIAVGQSLAALQALHEVVMSKRSRNTPLVSMEPIMLKYVELCVDLRKGKMVKEGLHQYKNIAQNTSVNTIELVINRFLELAEAKVTEAQAKADKITLDAIDDLEASETPESIMLSTVSGEQSKDRTDRSVVTPWLKFLWEAYRTVLDTLRNNVRLEVLYQSVSNQAFQFCLTYGRKTEFRRLCDILRNHLQNIAKYAHQAHSINLNDPDTLQRHLDARFNQLNAAVELELWQEAFKSVEDIHTLLSMSKRPPKPVMMANYYDKLTKIFMVSENYLFHAASWNRYSNIVRAINKNLTDDEQIAMANTVLLSALAIPVITTSRTRPGYVEADEQRIQKLNRLSSLLGLPQHPSRSALLKEALNKNILRRVRPEIRDLYNILEVQFHPLSICKKINPIMSQLAEDPELAKYVRPLHQVILTRLLQQLSQVYTTIKLDFVLELASFPEPYKYDASTIEKFIMNGCKKGELSIRIDHATQSMTFETDLFAPPKDTIAEGPKLQSSPADLMRTQLSRLGKCLHTTVQMIDPSVQQAAVRAKEEAFARALAGAEEEHKNTLARKQIIEQRKEHIETELARAEREAAQERALIAQQKAAAEQKRREEEQKRREADRLRKIQEEIQRDQAQKIADEIAAKTGMQLKPEEIENADVETLLNLKVSRLQSEQKELNERLKNIAKRLDHTERAYRKEEIPLLEKDYETQQKNDLAYYEAARKAQLKSAAAKHQEDIKIKSRVGRIFDDYNAFKKNIESQRQEVYRAKQQAIEEKIAQEKQKRIEQYRAQREEMIRQREEEEARQKAEEERKHRELEGTCNYRLADLEPAIILTFDFAEQEAREAEKAAEAEKRKAEEEERQKKLDEMARLQREKEAAIEAKLKEKSSPRAAPTDRWVPPNRRDPARDPAREPARDFAREPARDFARDPARDPAREQEAPSNDRFGRGEGGWRRAGPPSDDRFARRGGPSDRPSDRPSDKPSDSPPSSASGPPRFVARPGASTGGGWREREAAKRAAAGQSQPEGEKKDQDGFVPVRRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSV2</accession>
    <name>A0A8H7PSV2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_001995</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSV2"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="32"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2179145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="513" mass="56990" checksum="EF1698898EBF005A" modified="2022-01-19" version="1">MLFAKRKQLDNAALNQEKGWASQGGMLVLYWYSWILIINSAINGYDGSMMNGLQVLDTWSGYFNHPSDSQLGLLNAIQQVGGICGLFIASTMTDRLGRRWAIMIGSLIVLLGVGLQSGSTTVEMFIGARFLIGFGTSISGNAAPTLLVEISHPKQRGTMTGIYNASWYLGSIIAAWSTYGTFHITNEWSWRIPSLLQGIFSLIQVFFIFTLPESPRWLISKQKEEQALQILAKLHGNGDENTELVQFEYKEIVETLRLEELAAKRSWLEIVRTSGNRKRAFLVIAVGFFSQWSGNGLVSYYINKVLAGIGITDPNTQFLINGILQIFNLIAAYFGSWLVERVGRRPLFLFATFGMLLSFSCWTGLAAHATGTDAAPGVGSAFVAFIFLYYFFYDIAWSPLTIAYPVEILPFSIRAKGMALSSFAVNIALFFNSYVNPIALGAIGWKYYLVYVIWIMVEIVVIYFFFVETSGYTLEELSVVFDGEGAQISDLDKAALAIQNENAISEANPDEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PT15</accession>
    <name>A0A8H7PT15_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_003545</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PT15"/>
    <dbReference type="OrthoDB" id="510325at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07029">
        <property type="entry name" value="RNAP_I_III_AC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerases I and III subunit RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033898">
        <property type="entry name" value="RNAP_AC19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF28">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="8">
        <location>
            <begin position="69"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2179762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="165" mass="18278" checksum="A19D724E7B713674" modified="2022-01-19" version="1">MSPSKTRTHNEDIDEDVSSGDEEMVLAENQELMDTDEVNEDSADVEVEEAIVPADKIEIVSGSNSDPTCMTFCFKEEDHTLGNSLRHMIMKNPSVDYCGYSIPHPSEAKMNVHIQTTEQTNAVAALNKGFDDLTDLCQHVITSFKKELKSGNFEYSPEGKWASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTD9</accession>
    <name>A0A8H7PTD9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_002029</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTD9"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="15"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2179179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="842" mass="93671" checksum="B0F137B160E1CCD5" modified="2022-01-19" version="1" fragment="single">NFTVEEIRGLMDKVTNVRNMSVIAHVDHGKSTLTDSLVSKSGIISSGRAGETRFMDTRQDEQDRGITIKSTAISMYFEMENPEDIKEIKNQKTEGSSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCIEGVCVQTETVLRQALTERIKPVVVVNKVDRALLELQLTKEDLYNTFQRTVESVNVIIATYVDEVLGDCQVYPEKGTVAFASGLHGWGFTLRQFAVRYSKKFGVDKEKMMQKLWGENYFNPKTKKWTTKSTDAEGKPLERAFNMFVLDPIFKIFDSVMNFKKDQTATLLEKLEIKLAADEKDLEGKQLLKVVMRKFLPAGDALLEMICIHLPSPVTAQRYRVENLYEGPMDDECAIGIRDCDPKAPLMLYVSKMVPTSDKGRFYAFGRVFSGTVRSGLKVRIQGPNYEPGSKTDLFVKSVQRTILMMGRYIEAIDDCPAGNIVGLVGVDQFLVKSGTITTSESAHNLKVMKFSVSPVVQCAVDVKNANDLPKLVEGLKRLSKSDPCVLSFTSPSGEHIVAGAGELHLEICLKDLEEDHAGVPLKFGDPIVQYRETVQAESSIDCLSKSPNKHNRIYMRGMPLDDELAKQIEDGKIGPRDDFKIRARELADKYGWDVAEARKIWCFGPETNGANLLVDTTKAVQYLNEIKDSCVAAFQWATKEGPVADENLRGCRFNILDVTLHADAIHRGGGQIIPTCRRVVYASVLTADPGIQEPVFLVEIQCPDSAIGGIYGVLNRRRGQVFSEEQRPGTPMVTVKAYLPVNESFGFSTDLRAGTAGQAFPQCVFDHWQLMSGSPTEPGNKVYDIIRAVRKRKGLTEDIPGLDRYYDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTK2</accession>
    <name>A0A8H7PTK2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2 9">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_003730</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 9"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276422at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001018">
        <property type="term" value="F:mitochondrial promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.260:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.280:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1320.10">
        <property type="entry name" value="DNA-directed RNA polymerase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024075">
        <property type="entry name" value="DNA-dir_RNA_pol_helix_hairp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046950">
        <property type="entry name" value="DNA-dir_Rpol_C_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002092">
        <property type="entry name" value="DNA-dir_Rpol_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037159">
        <property type="entry name" value="RNA_POL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029262">
        <property type="entry name" value="RPOL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00940">
        <property type="entry name" value="RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14700">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01311">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00900">
        <property type="entry name" value="RNA_POL_PHAGE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00489">
        <property type="entry name" value="RNA_POL_PHAGE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase N-terminal" evidence="11">
        <location>
            <begin position="323"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1264"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1267"/>
            <end position="1281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2179943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1323" mass="148216" checksum="3C15933999B30A61" modified="2022-01-19" version="1">MSLPLASLYRQLPRRPFRPELLSSRTHGRSPCSASAFSKHRGASHQRHAGIATAEKISHAVETAENSIGREPPLEIMTSRVTSGPKRIVLPNPSLPAFKVASKVLPSSVAENFAVLYACIRSKDMDRASRIMIELYKNKPEEMKIFADNHIYNTFLEGFVEASPKPLTSQCLTWFDQMRKHGLNPDADTYAIVARGFMKASSFQTARAILQEMKKDTTFTIEQVLRSPYLKDGDDQLFQQLIEENRDNASRGVTEMLNELSKASETVFSKSGEEVMMETPTLPSQISEVPEVRSTNAAGVKFLQEHLATLSVSKKSGITDPYELQLRIEERAYEVALDKLNHEKQETLARGDKLGAMNLSPLKRIMWSWHQRLSPLIAEEVARCDKSSDSERRVYGPFLKLLPADKLSVITILELMRLHGSSGIADGMKTARALIDVGRAVEMEWNAVLMKQKQTQQSRLRNQETHALFSSGKLFNMALRRERMRLGQQREVPVGGVLNTTDGETVTTLDNGEWNPVWPSATRAKVGSILTSLLIEAAKIPTPSHDPETGKKITEMIPAFFHTYQYVRGKRVGIIKFSPNLTEMLSKEPVRDTLHPRLLPMLVPPRPWLTWNSGGYLSTKSICMRIKDSPEQVVYLKKASEEDCLDRVLTGLDVLGATRWKVNRPVFNVILQAWNSGEAIADIPPVTEGNLPLPEKPENYATDPKAKLNWIKQVKDIQNRERNHHSLRCDVNYKVETARAFLDTPMYFPHNMDFRGRAYPIPPTLNHLGNDLCRGLLQFDVAKPLGSSGYRWLKIHLANLHGYDKHSFTERENYVSENMEKILDSVDNPLGGSRWWLDAEDPWQCLAACYEVAAAVRSGDPEGFPSRLPIHQDGTCNGLQHYAALGGDLAGAQAVNLAPSDRPADVYTGVADMVNKLVDEEAAQGHPDAEILQGKITRKIVKQTVMTNVYGVTFVGARNQIENRLKERDDIPADKVYHLAGYLAKKVFASLGEMFNGARQIQDWLTDSAKRIAKSIPEETIRALDASIGEGFKVDTQDEQDKAAMEYAIDKIQSTASKKKTFSARNPTANQMSSVVWTTPLGLPIVQPYRRVAKRQVGTLLQTVFIEDPDASCPVNAHKQSTAFPPNFIHSLDATHMLMSAVACQTAGLAFASVHDSYWTHAADVDTMNKIIRDQFIELHKQPIMENLRQEFIERYKDYKVPMSVEVQKPAAKKKSKKAAAISPEKANEEVSTIGFAAEEIVEEELQDLKKKGDDDELNALFGSAVVDEDDDLDDEADAESSAEVKKPGKKYAHSWADLTFLPLPEKGEFDIQQVKESDYFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTS2</accession>
    <name>A0A8H7PTS2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTS2"/>
    <dbReference type="OrthoDB" id="5572108at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10206">
        <property type="entry name" value="ASKHA_NBD_Arp8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="589"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="647"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2180167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="788" mass="87494" checksum="FFD83E403F61B7FF" modified="2022-01-19" version="1">MSAQQNDSYLKSLSKKQYSWMQQASSPASETAPSPEPDVRTQDSPMHNTATDVADSVEPVPEEPANDPMDISEDMEAKKPAEDHSTAGQNGTTDSGRQRDTKSKPANNPKFKYTSFPVKGFNILPTRNITSQYAKADSVTTLGMLAGPDDIKPNPETEGSDVIIIHPGSRNLRIGRASEAFPRTVPHVIARKMNTSLTKSKSNTPPQVLSMDMDISQDSIEDDTDADVDAADEELPVHKTDTSQMTPLQASALEAIEGTLKYRMKMAKRRAVPNANAQVISYNSQAVQEIIPDHNDPYKVEWTDGDQEGKPEYYIGEKALNLPLDTNRDYRLLYPMKYGELNTHDYSSIQQVIGDLQVIWTDSIKSELEIEDKDFRVSFTSVTCFYSLKNYNAILVIPDVYNRSYVAEMITMMLRYMNFRGVFVQQESTCATFGAGVSMACVVDIGAQKTSISCVEDGLCLPDSRITLPLGGDDITTTFASFLKRNKFPYTSRDLSRSYDWKLFESLKEKWCTINEADISVQVYDFFVREPEKPTRKFQCKVYEEVFLAPLCLIFPGILEKDQKPMVVKTWNSENVIDDITDESAANNAAIQSQQPSTALAATKSKPSTPLPPGLSPVIKPLTAPSTPAADSEQATSPPPVDIDESTPIQSNAVTSESSMTPEKAEEVYIPTPIDTAVSQSIYSVASTSEERLKKFFTSIILVGGGGMITNLDRLLEDCIHNTAIAQKSGVEKVEILPAPRELDPRLLVWKGAYVLSKLESTNDMWIGPKEWNEVGVRCLRDRMLFVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUN7</accession>
    <name>A0A8H7PUN7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CobW/HypB/UreG nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_003982</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUN7"/>
    <dbReference type="OrthoDB" id="272672at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="entry name" value="CobW-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF62">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="CobW C-terminal" evidence="7">
        <location>
            <begin position="250"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2180193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="39509" checksum="212CC8AB9EB5555A" modified="2022-01-19" version="1">MAVDQPIPVTVFTGFLGSGKTTTILSLLKRLPEGYNLCLLKNEFGDTEVDSELARESNIGVQEMINGCMCCVLVGQMKLALLELKEKYKPDRIVVETSGSAFPAPIAWQIREMESDGFALDSIATVVDCVNFVGYEDTSYTAKLQAQYTDVILLNKHELVTERELDTVIDHINDLNTDTPKIKCEGTKGVSPDVLFGLDTKLFQLSMDKTHEAEELMFTTVPGGAPAAHDDHGKHHENEVDLIQVFETVDTAKPITSDELTSFLEKLPKEDIFRVKGFVRLQEGDENRLYILNHSFGRHTLTAVTNAETLAKTSKYVFKLTVMGMGLRMYIEIVRKGLKLDESCNVKFTAAHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVF1</accession>
    <name>A0A8H7PVF1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol-glycan-specific phospholipase D</fullName>
            <ecNumber evidence="3">3.1.4.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glycosyl-phosphatidylinositol-specific phospholipase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_008604</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10832"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57997"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:58700"/>
            <dbReference type="EC" id="3.1.4.50"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPLD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.50" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVF1"/>
    <dbReference type="OrthoDB" id="5317514at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004621">
        <property type="term" value="F:glycosylphosphatidylinositol phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001028">
        <property type="entry name" value="Gprt_PLipase_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029002">
        <property type="entry name" value="PLPC/GPLD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23221">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23221:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN-SPECIFIC PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00882">
        <property type="entry name" value="Zn_dep_PLPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00718">
        <property type="entry name" value="PHPHLIPASED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Phospholipase C/D" evidence="13">
        <location>
            <begin position="11"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="355"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="423"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="550"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2181022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="760" mass="84672" checksum="0FC7DB6278ADACC9" modified="2022-01-19" version="1">MLTPLYNSSVHNEVTHRASELLAGGFGNNVTAEYIQYITNSPSYVQAGSYFPDWGYQCLGYGQSSEDAHWPPFVRAAIAYIHDEYPEPWGDRETEVTGLIAFVFAIASHDIADVFWHGLGGFQESFIHAMAKQNFHGNTAKAHTAADAGAEFTLRHSAELQYFNSTWTVPARDLANIYFRMYTKLDGTPPSEADLVYCMRVGYAAFKADLRMGKYLFPHYGQQSPFLIENLNHYHRGGLQDMSLQVAKCWREVAMTFTDQSHTDTMCSPHWDSSRMTNIRNYKSLAATQSYEESLLILRQSGYNVMETWEESSGVVTLSVMQAESGSTPQQQVLGLDISLSQDQDLQSEECKEFEPDMTLTLGHMSGSLGYDMVLGDFNDDGFPDIAVSDPYYSEVDLHAGIVMIIDGRKHTHQLDNHSVFRASTMQLYNNVQESRFGWSMVVLDFNDDGIDDLVVSSPFDNQEQGSVNIYYGHADRGLSKEPDVVLQLSRQRGTYGFGTRLYALDIDGDGRKDLVVGCSHCGLPQAAQTGAMMVYLSSNNPPKHISSPNFSIRSPIIQGYEHFGSSAAMIEGRDGKRLLIAGSPGYSWSKAQRVGRVYAFSIDNMLKPRLQWTMNGNSEFQQFGSEIVTSGDNVIISSWSDDTSGFGRNNRWQAGSVGIYKASELIILHGQRNDDSGLSEKLYGKEMAGHFGTSFALEKGQLWIGEPLAQSEQGRVHIRNITSASDKLECIYLPNPRSRFGHRVAVNGKSKDNTIDQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVL8</accession>
    <name>A0A8H7PVL8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_008635</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVL8"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="45"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2181053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="542" mass="58826" checksum="FF0A8C9E21FA258F" modified="2022-01-19" version="1">MSKNDLDDTVKVQESSMDYNDRAHFPASAKDEPEVQEVEHVERVTVFVLCLTACVCLSGFLFVISGALQPIKDEFDLNDTTSEIVVGATTLGAIFGGLFAGICSDRFGRKPITLFSSVIFIVGAVIMAATPNYGVLIFGRLVVGFGVGLASMIVPVYLSEVAPRTLRGRLTTVNVLMITFGQLVSYLINIAFAQTYQGWRYMFGIAGVPALVQLLILPFLPESPRQLIAKGKNDQAVSALIRIYGKNVPETFVENELLRIKQGIEITKSGTYAELFKSYNRKPMIISCALQAAQQLSGFNCAMYYAATILHMAGFRSNSSSTYFSIVVSATNCVFTGVALTIIDRVGRRRILIYSMIAMIIGLFALGGAFAGQQGFMTQKSECVDYATSCARCVQDDRCSWSSSQSICAATNTLASSDIYQSSTGCPPQANENALTGILFASLVVYVAGYALGLGNVPWLMQSELFPLSIRGKANGIATAVNWACNLIISTSFLSMTNGVSAAGTFWFYGGLSIILWVFVLFEVPETANKSLEEVRRLFVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PW60</accession>
    <name>A0A8H7PW60_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Maleylacetoacetate isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_008523</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Zeta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PW60"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016034">
        <property type="term" value="F:maleylacetoacetate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03191">
        <property type="entry name" value="GST_C_Zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03042">
        <property type="entry name" value="GST_N_Zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000010">
        <property type="entry name" value="Maleylacetoacetate isomerase isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034330">
        <property type="entry name" value="GST_Zeta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034333">
        <property type="entry name" value="GST_Zeta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF4">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="122"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2180943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="29091" checksum="20C7561AD7E1D913" modified="2022-01-19" version="1">MSTTEQVTYNPQKPKLYGYFRSSATWRVRIALAWKGIEYEYIPINLVKGEQSSEEHAQRNTFKVVPVLSLPDGTNLVQSTAIMEYLEETHPGMLFDLRNKINRIQLLIAYNLYTDKPLMPKDVLQRCVVRSIINEIACDMQPIQNTKVQAYISSDKDKRVEWANYWLTNGCDALEKHLAKTAGTYCVGDQVTLADCSLYPIAYNAYRYKVDMSKCPTITRILDNLDKLEPFQAAHAHAQSDTLPELRGKTMKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PX80</accession>
    <name>A0A8H7PX80_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TFIIS central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PX80"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR A N-TERMINAL AND CENTRAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS central" evidence="2">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2182294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="136" mass="15598" checksum="2933FDD869CA6498" modified="2022-01-19" version="1">MPDDKIRSKSAELLAHALIGNEGDDSAIKDKCDRLASEIEEQIFVHHGNEVNVEYKEAIRSHVLNLKDTKNNLRNRLLNDQLNASTFADMEGQEMAAPERRMSDEKLRRNSIRDSMAVDDLQPMHRDDEDPDRGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXB3</accession>
    <name>A0A8H7PXB3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_006923</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXB3"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034620619" description="Peptidase A1 domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="49"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="351"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2181997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="439" mass="47809" checksum="F4B35C8FB81A645D" modified="2022-01-19" version="1">MRSTIFCLAALAQLALTAVAENHVTIPLFRRSPSPFYEAAGKQIDDGVLAGKVSVGTPPQEFNVVFDTSMLPRSFRTGLSWIRGSKCRTENCLDRCTYYSTRSTSAVSTGHKYSINYGDSCVDTRIYLDTVEFSGIKVPNMPIGGADRMSGFDAGFDGYLGLGPNIQFNKTGKLYAGQGNLQRRQTFENQPSSFVNSAFQIGQVQSPQFGVFVTPNATTYNTTTPAAPANPAAPQPATNVPPSTGGFTKRSDADCPAGYLIFGGVDTSKIDGSFKYLPLADPADGNSRNWDVCLRKADFGHGLSFDQHPDAIASISLSTSYITLPCRQADKFHDKIGGKYLESTQTYSIKCSEISKLPPLKLRFDEYTVELPASYWTKEVDAGRDCCQTLIRRGSSERDWVLGTSFTHAFYTSFDPEKEALGLGVIKGTSKNGIKITKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXX0</accession>
    <name>A0A8H7PXX0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_007327</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXX0"/>
    <dbReference type="OrthoDB" id="3098at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2182397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="698" mass="79368" checksum="3F5C91A995B937E9" modified="2022-01-19" version="1">MHSAPFAKAGPTDPMQTVQGSEIPDDIDSEFAEILDGSDHIDDDKRIVSAKYEALSRESQSHPVDQAAIGEHLAVLQWLQDTAPALPEKQYTKGEWRYSRPDGMEERSRKIGSNLKTTTMMDIDDHRYPQKRKVQHQGAEFNKKLTKSLFDFVRRGQIKEAIKMCDLCDEPGQSAGLYGFLVHNKCLSDRDEDLNLRRLTSTEATARNLWEMSCRQIARDNTLDVYERATYAALCGDMENTLPACTTWEDLVWAYYNASVENLLGEILMPDFVGSNGLPSEEAIFSSAQRKDIGSDAATQCFHQIQALIITNQIEFLVSTLHEALVLKKGNSNFPLPDNSSLHSQFLRFATLFILYLTSISAYTPNSTSDSIISEYIKFHFQFDAGLKAQLVALYCSKLSNSHLQAEVFADFLNGFDGDRSERALLVEVGEHHQLDMKQILRNLYQKSAKAFMQKQPVARSRVGLMNDSVSPETLRHIRTLEWLTFERQLYADAITQTNNMIRHFLAQGDIKAAQIVFTVIPASVISSVLAEPISNGINLTTVVKELRLHDTLVDIWGLYNLWETLRAKRPAKDDTLESLRAYRDWASQYEQLSINLVNKLQYIIRSNWCRSADDPDQIIPNTVLREMYIPELVLNLHQILYYTHDLLPGHLEKSLQISDMVADDDLGLGIEFVRSRRMGEFVQRIQQSSVQLLKQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZN0</accession>
    <name>A0A8H7PZN0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZN0"/>
    <dbReference type="OrthoDB" id="10402256at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2183198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="126" mass="14683" checksum="8FC9BAB533FEF58D" modified="2022-01-19" version="1">METTISLPAIRHFTARIYNLSYAKTKKVKTFNCDIHRVIMPEGMDLYCVQNKTDKKIVVALSEIPFTLGPNDVMHIKDKIASYWVKFLWLSKPGDIQDKRIVRTDETKYVDMVAYSNAQDFIKHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZS2</accession>
    <name>A0A8H7PZS2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Etoposide-induced protein 2.4-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_006141</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZS2"/>
    <dbReference type="OrthoDB" id="266518at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059112">
        <property type="entry name" value="CysZ/EI24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21389:SF0">
        <property type="entry name" value="ETOPOSIDE-INDUCED PROTEIN 2.4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21389">
        <property type="entry name" value="P53 INDUCED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07264">
        <property type="entry name" value="EI24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2183146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="35251" checksum="183027D068DC7415" modified="2022-01-19" version="1">MATSTRAPIQHHIEYFVSGLRQACAWPRTLILLYASSTLRKAAIEAFVLNGVIFLGTVLTLETFYDHPHNHFLGCPYRILGGYPIYIVCIAFNGRVNKKIADHTYQIQQNQATGRSNDVQAAQSAAQKQATSTSPVQNVAYVIYQMLFYASCAIFLGVLQMIPHIGTPISFIVSCWFISYYAFEFKWVNLGFTMDQRMAYLEKHWAFFLGFGLPLTTLTFFLSSLRSAAVYAVFFPSFVIMATTAIVLPSANVHSHSIPSGNTSELKDVELPNRLPIYIGVKKLNELVISLIRSVGGVRGNSLLLDKKKEAFGKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZY6</accession>
    <name>A0A8H7PZY6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZY6"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106335">
        <property type="term" value="F:tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051422">
        <property type="entry name" value="AlkB_tRNA_MeTrf/Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF21">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="61"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2182206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="251" mass="28246" checksum="A48C054B5CB927FE" modified="2022-01-19" version="1">MSKPQPVAVSTPNENEKAYEEEHVHKVYQTIASHFSDTRYKPWPVVENFLNSLTPGSIGADVGCGNGKYIGVNPKLCILGSDRYRILVPKQSSNLISIVQERGFEGMVCDALSTPYRDSTFDFAISIAVIHHFSTPERRLVAIKELLRIVKPGCPILIFVWALEQSKFSKRNFDRTQQDVFVPWTLSASAKPSAEAKDDLDSEDASKQIYQRYYHLFAKGELDELIVNTGLADITSSGYDRDNHYVIAIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q011</accession>
    <name>A0A8H7Q011_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Clp R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_007470</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14855">
        <property type="entry name" value="TRAPPC1_MUM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="Double Clp-N motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0143">Chaperone</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="BRO1" evidence="16">
        <location>
            <begin position="165"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="domain" description="Clp R" evidence="17">
        <location>
            <begin position="570"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1437"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="206"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="979"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1445"/>
            <end position="1459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2182539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1465" mass="161773" checksum="F5012804DF9BF6E1" modified="2022-01-19" version="1">MNATSTSTSASRAGGILNSTSRYSTSSATSNVIDSNPAVSSGGSSYKAGNDSNRISSMQSGVAAGNAMSLEEEAKLVYGVVLSLRNFVRKLSGKQDGFIAYKTSAYKLHYYETSTGLKFIINSDPNADSLRPVLRQIYVQLYVEFVVKNALMRFDDTRWTMGSTPSNDIPISGEDEGEVGQKKDEQQPPPGYIGNELFRVAVDRQISEATAQRGRLRAALKNIKRQEQLNKDYQEVINTIDDYLPYLYGIIGCIESKELKPRGPIITSWRSTLSGHNKGIAGQKPRLNCQGIGAELCFVLMTYAYAHCLRGSEIVSSILPESENSEIQYNKAADMLNRAAGIFTYIAEQVDLPASNSTHSMAIELHNDTATALSKLAAADAQSAAISKALIHSKVSNSLIAKLYMGVANQYETANGLLSSLPSSEVGSDLKRYLSDGTAFYKAMAKKHLGFDANENQKMGIAAGFMREAKLELHALKKVSKSTLSITHSTVALKATKEEEVVIDLFNSFTRINDTVSYQPVPTRQELQKLVPNGRGILQLKQYNPPEQCFGPKATGVTSQQYARAGTYCSGMQFTDKVEKLLGQAQSLAQEFSHVQLAPAHIACALFDESDGGSLLKNVIQKAGGDPALAERGYKKMMVKLPTQDPPPVEISLGPQAAKVLRNAQTHMKNQRDSYISVDHIILALADQDSTFQPLKDAGVTKKALQNAISTLRGNKRVDTKNAEENYEALSKYAIDMTVLAETGKLDPVIGRDDEIRRVIRVLARRTKNNPVLIGEPGVGKTAIVEGLARRIVERDVPHSLQCKLFSLDMGALVAGAKYRGEFEERLKAVLKEVKDSEEGIILFIDEIHTVLGAGKTEGSMDAANLLKPMLARGELRCIGATTLTEYKVIEKDPAFERRFQKVDVGEPSVGATISILRGLKERYENYHGVKITDAALVAAAQLSDRYITTRFLPDKAIDLIDEAAANTRVQLDSKPEEIDVLERKHFQLEIEATALSKEKNNAESQERLAAVREEMAKLQEELKPLKSKYELDKGRLDEIRDLNQKLDELKRKATEAKNRYDLATAADIEYYAIPDVEQRLQELTAAKKRRTSEAMASNEDQLLSEIVRAEQVMEVVARWTGIPVQNLARSEKEKLLHMEQYLSKEVVGQESAISAVCDAIRLSKAQLQDPNKPLASFMFLGPTGVGKTLLCKTLAEFLFDDERALVRIDMSEYMERFSVSRLIGSPPGYIGHEEGGELTEAVRRKPYSVVLLDELEKAHKDVANVLLQVLDEGHIHDSKGRKVDFRNTIIVMTSNLGANLLAETSGVTDANAMVMIKEQILSVVRQHFSPEFTNRIDELVIFNRLSQSSMTGIVDVRLQEIQQRLADRHMTLDVDQAAKEWLGQTGYEPIFGARPLNRLIQNKILSPLARLVLDGGVRNGETVKVRVNSAGDNIEVSRNHDADGTYDYEEPDIEEVDGDTAMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0P7</accession>
    <name>A0A8H7Q0P7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10551860at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034075822" evidence="1">
        <location>
            <begin position="25"/>
            <end position="2088"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="2088" mass="204796" checksum="CE833E343ACA04B0" modified="2022-01-19" version="1">MPSRSFFLLLSIYVVIILSLKVRAGGGKDYQYDREEDDWDDGYEDDYYTNALATIVVGSQTYKVPYATTPVTLNPVLPTPTCTPGKISVIDEPSSSSPVATTTGIITLGKGAEHHVISVTCGGSSDQTIDIGTLFPNIPASSATKCLSTGSITLGKGTKTRTVPINFGAISSSVIDIGLLYPDDPASCVTECTSTGVITLGQGTNTQVIPVQCGANENSIIDIGTICDIHATASATSPGTSCITTGAITLGKNAAARVIPITCGGAINQVVDVASIFSDAATTGAVTLGTGINRQVIPVTCGGDSDQVVDIDSICPKPTTTGAVTLGTGTDHLVIPVTCGGPDNLVVDIDSICPKATTTGAVILEGGTETRVIPVNCGATDIPVINIASIYPKDCAGCATSCVSTDAVTLGTGTDSQVIPVTCGGNGNQVINVDSVCLKATTTTTGTVTLGAGTDSQVIPVTCGGSGNQIFNVDSLCPAAATITTGAVTLGTGTGSQVIPVTCGGTGNQVVNVDLLFSMATTISTEAVTLGTGTDGFVFPVTCGGTGNQIVNVDSLFPRATTISTGAVTLGTGTDGIVVPVTCGGTGNQILDLNSLCPKDITTGAVTLGTGTDGVVFPVTCGGTDNQFVNVDSLFPKATTISTGAVTLGTGTDGIVLPVTCGGTDNQVVNVDSLFPKATTTGAVTLGTGTNGVVFPVTCGGTDNQILDLDPLCPKGITTGAVILGTGADGQFIPVTCGGTSYQVLNINSICPKATTTTTGAVTLGTGIGSQVIPVTCGGTSNQVINIDTLCPKATTTTTGVVTLGAGSGSQVIPITCGGTGDQVVNVDSLCPDAITTGAVTLGTGTDGVVFPVTCGGTDNQFVNVDSLFPKATTISTGAVTLGTGTDGIVLPVTCGGTDNQVVNVDSLFPKATTTGAVTLGTGTNGVVFPVTCGGTGNQILDLNPLCPKGITTGTVTLGTGVDGHIIPVTCGGTDNQIINVDSICPPATTTTTGVVILGTGTGSQVIPVTCGGTGTQIVDIVSLFPKATTISTGAVTLGTGTDGVVFPVTCGGTGNQVVNVDSLCPKATTISTGAVTLGTGTDGVVFPVTCGGTGNQILDLNPLCPKEITTGAVTLGTGVDGQVIPVTCGGTGNQVVNVDSLFPKATTISTGAVTLGTGTDGFVFAVTCGGTGNQILDLNPLCPKDITTGAVTLGTGVDGQVIPVTCGGTGNQVVNVDSLFPKATTISTGAVTLGTGTDGVVFPVTCGGTDNQVVNVDSLFPKATKTGTVTLGTGTNGVVFPVTCGGTGNQIFDLNPLCPKDITTGAVTLGTGINGQVIPVTCGGTGNQIVNVDSLCPKATTISTGAVTLGTGTDGVVFPVTCGGTGNQVVNVDSLFPKATTISTGAVTLGTGTDGVVFPVTCGGTGNQIFDLNPLCPKDITTGAVTLGTGINGQVIPVTCGGTGNQVVNVDSLFTKATIISTGAVTLGTGTDGVVFAVTCGGTGNQILDLNPLCPKCITTGAVTLGTGTAGQIIPVTCGGTANQVVNVDSVCPKATTTMTGAVTLGTGTGSQVIPVTCGGTGTQVVNIDSLFPKATTTGAVTLGTGTNGVVFSVTCGGTGNQVLDLNPLCPKGTTTGAIILGTGTDGQVIPVTCGGTSYQVLNINSVCPKATTTTTGSVTLGTGIGSQVIPVTCGGTSNQVVNVDSLFPKATTISTGAVTLGTGTNGVVFPVTCGGTGNQILDLNPLCPKCITTGAVILGTGADGQVIPVTCGGTSYQVVNINSICPTATTTTTGAVTLGTGSGSQVIPVTCGGTGNQVVNLDSLCPKAATSTTIAVTLGTGTAGVVFPITCGGTNNQIVNVDSICPKASTTTTMTGAVTFGTGTGSQVIPVTCGGTGNQVVNVDSVCPKATTISTGAITLGTGTAGVVFPVTCGGTGNQIFDLNPLCPKGITSGAVILGTGINGQTIPVTCGGTPYQVVNLSSICPTATTTGAITLGTGASGQVIPVICGGTGNQIVDINSICPKATTNGAVTVLTSSVASTTVTSTKSTSTAVYAFTVVSGTSTVTKTVTCSSQCNSVLSFTISTGSATSTKVLTASCTSGCSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2L7</accession>
    <name>A0A8H7Q2L7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_000686</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2L7"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050608">
        <property type="entry name" value="NmrA-type/Isoflavone_red_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43349:SF93">
        <property type="entry name" value="ISOFLAVONE REDUCTASE HOMOLOG P3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43349">
        <property type="entry name" value="PINORESINOL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2184773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="305" mass="34534" checksum="042B5472904F07E9" modified="2022-01-19" version="1">MSKILIIGATGWLGSAIVDAFQETSHQVRAFIRPENLNNPEKVTSLNKLRQRGIQLVPGDLHKKEDLVAALKDIDVCICCLGIFQGAEQLPVVEALKEVGTVKRFIPSDFGMDYRRDPHDFDMTEKGIIVHQAMFEAGIPYTIIDNGPFMEVGLGKLLDWSQPAPVTLETTTIRRWGDGDVEVVTNALPDIARYVVQIVDDPNTINKRIMLDGHPTTQNQLLDLWESITGKKLERKRTDEAELQAMIDKTEGFKQFPLKLARCGFFRNGFVRSDDYLSASQLYPDLHKTTTTIQEFLERRYKSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2V8</accession>
    <name>A0A8H7Q2V8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2V8"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="455" mass="50887" checksum="953C210E9FE2EBCA" modified="2022-01-19" version="1">MLGVGDIVVHGYAHRSELEGRVVCGTVIDNGFGQFVTKLSFSSAFPKLLLKDRGVKKFEKEIRIFAMYKALTMLDDDMFRAYRPQENHVLTEEIIRQVAIYLFTINAVDRLRHLLSRYGQFFKDHLDLLKGEDILTNLGMPISQYLDIPLFLTKLCNAIYWCRPTTALKIGSKICNVADDFEESRRHIVELYREAVSDVADDAGSGSKCCREYDYCACSTLPTEYVTVDFYKMYWRLPCVIIAENEDEAYKDLKRDPKFKVTKLGVRGLPNALHDAWAGQHALIAGESYLLSRYRSNLKRTQRDLDDILKEALSTFDNYKQSQKLSRNTNESPTGVSGLGNGTDLTTHKSVTAIASISEHTTITAITANSTKSRSDSADSSTASPLIKSRITPNDGEIFTASTATLPDPYTGGTSENTESSDPASDCYSWPCCKSDSFFDILTSTSGIIDQDQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2X6</accession>
    <name>A0A8H7Q2X6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2X6"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2183691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="173" mass="19167" checksum="FB4D0F09C7E143D1" modified="2022-01-19" version="1">MTTDSEVNHRHPEELTIRSALSHYSPADNVSHEHQSMFSRAFAKIEEVLGLKGDDFMSASEMKDAHDEFYLHGGDTEAKTTVSIDRIGNFIAAAAAAEAGYAFERHASLQKFDENEKKSLDFMVGFSMAEAIKLFEQLNNRHATNEEREQIAASAGAHAKAFYSQSFAHPAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q345</accession>
    <name>A0A8H7Q345_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q345"/>
    <dbReference type="OrthoDB" id="4088568at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="628"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="643"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2185072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="688" mass="77346" checksum="DCECF2812289CADC" modified="2022-01-19" version="1">MPDRQDHDPLSDSLEHLIASRHSQHEENTNISCCCGRNDCPRQLSNEQQIQKAEADARLAAEIGQTLLQRHESYAQDAQAIQSNLQQKLRQLMTNNKQLEALNNEVNLDKEQALEDRDRALADKERSRKMTEAIKKDLELVSARCKALEEEKEAKESELQGVKALQVIVDQNQSMEQTMQSKMNDLLQELSSVQRNEVATESKYKKLKSRYDALHASYQMTKRQMKELENSSEDHRAFAWLKESNSKLRHDLKYIYSGSANRESQNSQLISLIQELATANNKLKGEILDQQATISYLSSRVQEAEKSDLDIEHDIDLAGDDLDIANHTTTGSFNIPISSPRKEPTHNDLSSTLSGGSWSSSILATSPLRYVKVHEELEPAPQLGNQSLLSKMDVANNSSQSTPLKTALQRKTSPSPTDHPYGVAIVKPERSSSTPLKTKFGSPLSQTSVFMTPSPPQSPNIVSQDNKHPYKMLHDLAAQLFKRLSGTEIRVLNRRLHRAFDMLKLTDLSNSIIDNVDQDIQSLDSRFSWVQQAVREQEQTWAHETIALSSFFVMVKLVQELLAEIGTLRTTLNSLQVEYVNKVNDNQSYVEKALEEKSNLDPVTNSAPRQDETAGTFSWLAQMITRAPSSNEAVKSDDDASIKTRTSANDEVAQSTSSISYLSNSIYRLAQSYKGSNTNNNNNDVQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3N3</accession>
    <name>A0A8H7Q3N3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3N3"/>
    <dbReference type="OrthoDB" id="10372009at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="270" mass="29695" checksum="030E29FC04DF1B33" modified="2022-01-19" version="1">MSFIIPLAETFYIVQIIINSAVILSILLARCVCREKPRFHVYLLLLANLFGIIYSAVWLHEYSFQGNSSAQYNAIDQNTATAAMIFTNLASNFAFLVGFFALQQVTKTYLGGTQLWIKVASALASLWTLAVLILSGVASSNLSVWNLLMIISIIGWGMVALCALLLLVLVGVRIFYNNRVPSGIARHQVVLTFALVAVYICLLTVDVIFSTVAPYVNDTGSMAVAGLIVDIIFFRAPGFLFAVFYRRLSAMPPYAEQMDVECADVQPLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3P8</accession>
    <name>A0A8H7Q3P8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase II transcription factor B subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_002347</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TFB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3P8"/>
    <dbReference type="OrthoDB" id="364513at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2610:FF:000001">
        <property type="entry name" value="General transcription factor IIH subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00625">
        <property type="entry name" value="tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor Tfb2 C-terminal" evidence="10">
        <location>
            <begin position="398"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2185909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="475" mass="54332" checksum="62E9420F9EB3B5FD" modified="2022-01-19" version="1" fragment="single">MSVINFKTNIYDYLETLPIFTFQRLFQKPATCLAIFRLLPAIGRQIVMSILYVEIPIPLKDIQSWVYKDGHRKLQEALHKLSKLHILEETSEKHLIVNSTFRLEFKNALSGGGDHQSFGLPCATADKHKVDIAFLDHFASTQWEAILHYMVGTAMTKRPSRGVLNLLQKSDLMQASESETGLHITNKGFQFLLQDVNTQVWAFLLQYLDMAEMLKMDLVEVLNFLFQLGSLELGQDYSVETLTQTQQQMLEDLGDYGIVYRRKKGSRRFYPTRLATTLTSGTSALMTSFAKKENASTASSAMMTASDENKDEGGFLILETNYRVYAYTDSPLQIAVLNLFIQLKSRFPNMVSGVITRESVRNAFVNGISADQIISYLQTHAHPQMRKRAPLLPLTVVDQIRLWEMERNRITEKAAYLYKDFSMQADFEAAEKYARDMDVLLWSNSKQRKMVIAQEAHETLRTFIKRRLAGNRDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3Z5</accession>
    <name>A0A8H7Q3Z5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_000803</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3Z5"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="616"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="375"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="689"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2184890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="721" mass="82616" checksum="F553361B30BA7251" modified="2022-01-19" version="1" fragment="single">ARGKCLCCGSDLRFPASVSCFRCTICDTINDLISSRKESTDFIPRPLSLPKLKQIVTRCGGKDLRRRSRNRKSNGINMSDKELETLFNPVESAIEACFSSWEALNNSFTNGKETTLTDSGISLDEVREAYRIILDLPVNVIRAMMTSIDKLLRRPGIPLKRISDIRFLLIMLENPLLAQHNFAEETRYHHNILKRILGMLSGLSNECHQAIANWFANLSTPHLQKRINLVNAFITYRITKARRSAAGLPAAYESDWRVISGARVMALLFAANSTAPKIPLSAFYNTMVDYVNLMADFESWQSRSGKFSFCQYPFMISMGAKMEIMESDARDQQETKWREAFLNMLFHQKPTMPYLILRVRRENLIEDSLRQLAQNETDLKKSLKIEFVGEDGVDAGGLRKEWFLLLVRSLFDPQFGMFTYDDESTFCWFNPASFENEDQYFLVGIVIGLSIYNSTILDIHLPTACYKKLFGYHVGLEDLRVFRPGLARGLEQLLDYDGDVEAVFCRPFVADYDAFGERVSVPIVQDGEEIMVNNSNRQDFVDRYIDFVMNTSIKRQFGAFKRGFYHVCGGNALSLFRPEEIELLVRGSDEPLDIEQLRGQTEYHGFEETDDTIEQVFSFLLLFVNIPNLTIIFRAFWKLFKEMQPTMQRKLLTFVTGSDRIPATGTARMRFQITCGGADCDRLPTAHTCFNQLILFRYASTEKLRRMVGLAITESQGFYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5B6</accession>
    <name>A0A8H7Q5B6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5B6"/>
    <dbReference type="OrthoDB" id="2253519at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2185830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="146" mass="16318" checksum="11CB2B14C6E3CD30" modified="2022-01-19" version="1">MPGNDAGVTPSEVYERSSKALESLSKVWNVSASVIKAITEVTDSSLRSEPDYQAVQHVKREHDQAVANLKTEFEWLEQHIPSLSDTDDSASDEKQMRIDALQQEQEELRVQSAKLTSRVKQLLEQSYALQHHLGLLIASSEDLSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6H2</accession>
    <name>A0A8H7Q6H2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6H2"/>
    <dbReference type="OrthoDB" id="2422716at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2186445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="218" mass="24781" checksum="5671897352555C64" modified="2022-01-19" version="1">MVHAAKPETAWKIALVPSISIQLTWMDALVLLASSVGMWGIARADRIMMRVQLIIATAVLQNRDHYILHNLRQSWIRAYESNKNVILDIQREFRCQGFAHPEDIMVQMPEFYGALTGCQLPLVQTFGSKMYSIGVMTMIIRLIQFVGIFLLSFVLHQIRIADNEADMPEDEEITEEEGKMLLINEALYLDDSDSGSVDLISFNDDEKFALKETIQTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6H5</accession>
    <name>A0A8H7Q6H5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_002648</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6H5"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01493">
        <property type="entry name" value="APPBP1_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000475">
        <property type="entry name" value="NEDD8-activating enzyme E1 regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="6">
        <location>
            <begin position="36"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2186210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="557" mass="63098" checksum="5D165BFA43019D2B" modified="2022-01-19" version="1">MLCDELELHAVGQALDELLVPGTIMTAVPDLKAQKYDRQLRLWAASGQAALENAQVCLLNATTTGTEILKNLILPGIGAFTIVDDEVVSEIDIQRNFFLDTSCIGSPKSKSTMQFLQELNVDVKANYEEKSAGYYIDENHAFFDQFTMVIATSLHEAHALKLASICQARNTPLFLIKCVGFAGMFRIQAGEHTIIETHPENATDLRLDVPFPEILEYVKSFNFANMDSSEHGHVPFIVILQHFLQAWKLSHDGKLPESYAERNEFKELLKKEMRSFDEENFEEAIANVWRLASPSKVPDKVKEIFKEPKCENITKESSNFWIIARAIKDFVYHEGAGLLPTPGKLPDMKADTKSYVQLQQIYRQKALQDLEAVKARVQSLLTEVGLLPDAIDAREIEEFCKHAQFVKVIRYRSLEDELIRKVHKSEISQWLEESDPTNNIVHYIIFRAADRLANNQIQSVGQKEEDAAVKALEEATRQVLSSMDIPQDKVTYMLDSHLRKYVVNFVRYNGSELPNIASLMGGLVAQEVIKVITRQYIPIDNTCIYDGMTATTSIYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6N4</accession>
    <name>A0A8H7Q6N4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6N4"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051948">
        <property type="entry name" value="Hsp70_co-chaperone_J-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2185701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="125" mass="14732" checksum="85B292B235202F42" modified="2022-01-19" version="1">MFKSAGRQSYRAYSRKRLTRSPFQILGVSQSANKAELKQRYYELCKQYHPDKAGGDRERFQEINRAYQIVSNKSRREMYIRYGESWDQPHTTSRRDPEPEVGIQTRNSILTGLTISLCVMLYMVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7K5</accession>
    <name>A0A8H7U7K5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_008060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7K5"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2171680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="322" mass="36074" checksum="906299DF60FF4E35" modified="2022-01-19" version="1">MAQTTLTLNRTGDKMPIVGFGCWKVANEDAENTIYTAIKNGYRLIDGAADYGNEVEVGRGINKAIKEGIVKREEIFVTTKLWNTYHSKDNVRAAFDKQLKDLNLDYVDLYLIHFPVPLKNVPIETAYPPGWYQPGEDKVQLERSPLHELWPEFEKLVDAGLARNIGISNMNVQLIMDLLTYAKIKPSVLQIELHPYLQQSVLVKWVQEQDIQITAYSSFGPASFVPLGVDSAKKAAPLLQHDDISAIAKAHNKTPAQVLLRWSVQRGCAVIPKSSSEDRMVSNADVTSWSLPEDAMAKITQLDLNLRFNDPSGYGFNLPIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U879</accession>
    <name>A0A8H7U879_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U879"/>
    <dbReference type="OrthoDB" id="407630at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="208" mass="23619" checksum="739FD24F9EAB21FE" modified="2022-01-19" version="1">MKLFKSVHTYDYPWSLVSAANWQKYPNEHCPHVQAVDVLDRRVDPETGILVTERLITVKQNVPTIMLKVLRNSVIQQLRTEEYSNIILLQLMGTGHTQYVREISRIDPKQKTMTMDSINLTLSNYMSVAESITYEEHPIEPSKTQFTQQAAISAGIKLSRWASLVEDFSANRFSQNAATGREGFNEVLQRFVVRAEGSSQSQSRPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UA33</accession>
    <name>A0A8H7UA33_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase C51 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UA33"/>
    <dbReference type="OrthoDB" id="2251794at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50911">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034365554" description="Peptidase C51 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C51" evidence="2">
        <location>
            <begin position="107"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2172373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="236" mass="24830" checksum="1890D2CE2242CC97" modified="2022-01-19" version="1">MKVSIAALFAATLGLVDLAVAYPITHASALNCRSSPSASATLVKTYSADADIKISCQTEGQSIEGSTIWDKTQDGCYVADYYVKTGASGYVTGTCGSSGGGGGSIPGPVTDDYLYKGQCGGVDPWLYYKCQCTSFVAQRINKRLGLSFNNKYKGCAFGNANTWYSAAKNCGVTVNSTPVPGSIAVYTGGSAGHVAWVSSVSGDTVHVEEYNWNNPEKYGTRAVSKSSFTGYIHFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UA84</accession>
    <name>A0A8H7UA84_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UA84"/>
    <dbReference type="OrthoDB" id="2405412at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF6">
        <property type="entry name" value="MANNAN POLYMERASE COMPLEXES SUBUNIT MNN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034542408" evidence="2">
        <location>
            <begin position="22"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2172239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="343" mass="39198" checksum="7504E25FED7E4368" modified="2022-01-19" version="1">MVTGLALLILTGISLLSYSRSSGLFVCNTGRNIRFLSSEAAAMTAAEARTAQYTFTNLNALTADPQSHVLILTPLKNAEAYLPRYFELVNRLTYPKELISLSFLVSDTNDRTVDMLRQFANENRHFHRVSILERDFNYELPEDKRHTFELQPLRRSMMARSRNYLLTASLSTEHAWVVWLDVDVVEYPPTILEDLMSVDVDVVVPNCLWDTEDGSFWGYDKNNWQETEESLAIQKDLDDDYVLLEGYYEFLTSRKLMVDMPTHTDKLDKVELDGVGATFTLVKAEVHREGANFPAYPFQHEVETEGFAKMAKAMGFGVYGLPGYIIKHIYNNCKFTGYVICTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBA7</accession>
    <name>A0A8H7UBA7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-tyrosine-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_005021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBA7"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF14">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE OCA6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="247"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2173603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="42734" checksum="1C6731C27269FF24" modified="2022-01-19" version="1">MPTLPPLIPPFRFAAVEDNVFRGAYPKQRNLRFIKRLVRGEGHDHERLPDVRLITLLFVRLHLKTMLSLIPDPLPDDILSYCDEQGINAIHLRVDKMKEDNIPLTYSRTIAAIQTIIDPENQPIYVHCLDGSDVTGLVIACLRKLQMWSTSSAMGEYLRFLRSNVISPEVFEFVEKFFNLDVTIPMAIPPWLWGGTVSFRKHPSLKLKFLNPEMMTEEEREIKDLKEKKEKDKEEYYRKRKNDLLDNLLDQSGTSGSGRNRQQSQHGGSSQANAAQSSSTACDDNNADENGDVDQVDDANKKDTNAEDELLVDVDVDAMMIGDLNELNYYDQRRDEDPDKEVIPEDGTGLSADGRYQKEPLSLLLRALALEGLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBH9</accession>
    <name>A0A8H7UBH9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBH9"/>
    <dbReference type="OrthoDB" id="2422919at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="288" mass="32457" checksum="976C95A9AE982432" modified="2022-01-19" version="1">MALPDTVHTRLSEKSAPASRAGFQVKDNRSYHDDSSDDGFYDYLSEEDDDYDEISYLRHKVNRLELDNKYLSQQNTHLGKEMSFSRYTVIAMRNMVSQKESSLQAASQELDKAHFRIRMLESMLMGHHYDTGSAGMDQSHQRSRAISALKNHRSNYEGPEEDEGDSYYDDDDDYEEAPSPVVAPSMERGSIKALLPIRTPSPSDDISESRRFSQDISGSASDSDESSIHQSSPPSHPSDDKVNIWNKSEDLFADDIVDIVGWHDDDDTNSVLKTVQTSHIPQPVATSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBJ0</accession>
    <name>A0A8H7UBJ0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBJ0"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032451">
        <property type="term" value="F:demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070988">
        <property type="term" value="P:demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032857">
        <property type="entry name" value="ALKBH4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463:SF1">
        <property type="entry name" value="2-OXOGLUTARATE AND FE-DEPENDENT OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463">
        <property type="entry name" value="OXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="87"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="198" mass="22406" checksum="31CBDAA042BD5AE2" modified="2022-01-19" version="1">MSSIPGLTVIEDFVSPEEEKKLVENCDQQTWSGLGVSPNPELKRRTQQYGYLFSYQYRKVLCELGPFPEFVTAVVARIADQELTSRPPNHLLVNEYEAGQGIMPHTDAPSIFGPVIMSLSLLSPCVMQFTHCETGEKIDICLPRRSMLVMTDEARYNYKHSISKDLIETLSDGTVIERSRRISFTFRTIVSFTGECSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCR6</accession>
    <name>A0A8H7UCR6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endoglucanase</fullName>
            <ecNumber evidence="9">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_005836</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the glycosyl hydrolase 9 (cellulase E) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="9"/>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCR6"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001701">
        <property type="entry name" value="Glyco_hydro_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033126">
        <property type="entry name" value="Glyco_hydro_9_Asp/Glu_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22298">
        <property type="entry name" value="ENDO-1,4-BETA-GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00759">
        <property type="entry name" value="Glyco_hydro_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00698">
        <property type="entry name" value="GH9_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034555006" description="Endoglucanase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 9" evidence="12">
        <location>
            <begin position="53"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2174774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="551" mass="60655" checksum="F64D2479918BD2F0" modified="2022-01-19" version="1">MRSIPLLSLLLLQVTAQDDSESSSTTTGATSTPTSSSTPSPSSSTLPTVNQAYTALLNDSLWFYEAQRSGNLPANNRVPWRHSSALQDGSDNNVNLTGGYYDAGDYLKFTLPMAYSMSIVSWGAIEWFQGYQAAQQDGYLRDMVKWGMDWLIQAHPQPNVFYVQVGNGDIDNNYWGPDTNIPTPRPSYMINNTSPGTDVAAVGAAAFASASYLFRNRLNDSNYADTLTSHAISLYNFAETASPQQPYTTSIPAIAEFYQTNTIQNQLVWGALWLYRATGNQTYLTKASKYFDQFNLSSVDITPMDWSDQSGGVFVLGSMLDNSTQKYRAAAERYLDTLTQGQGPCSFTGGGLLWCGQSSASNSLIPAQDTALLALLYSGLNSDKGSGYTKFALGQIDYLLGNNPMLTPYVVGVHMNSPANPHHAGASGGTDINNINTSPPQELNVLYGAIVGGPDQSDNFYDVRNDWQQSEVALDYNAPFQGLVAYQLVTNASDPPYTTITQPRPAIKKPFPKWAIAIIVILLVLLLIALALLWWKRKRIIEWRRRRKQNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCW9</accession>
    <name>A0A8H7UCW9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCW9"/>
    <dbReference type="OrthoDB" id="2957314at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034364579" evidence="1">
        <location>
            <begin position="31"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="148" mass="15055" checksum="67F7A754D9959CEE" modified="2022-01-19" version="1">MCAKTSSPSRMVKLTAVLMLVLGAVAAVTADDESFDRASSLQARSDGGGSVERVALQSRFEIPRSGSGSGSYKHIFAALEKRSSSCEAGYFLCGDSLGGCCPNGSHCVSGSFTCTYSSIVPHSSDSGTAVSLAKSAALASALALFAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDA1</accession>
    <name>A0A8H7UDA1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_007994</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDA1"/>
    <dbReference type="OrthoDB" id="10264412at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000152">
        <property type="entry name" value="Isoleucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000009">
        <property type="entry name" value="Isoleucyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.830">
        <property type="entry name" value="Ile-tRNA synthetase CP2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02002">
        <property type="entry name" value="Ile_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023585">
        <property type="entry name" value="Ile-tRNA-ligase_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="75"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="645"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="759"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2177337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="999" mass="112627" checksum="F2BA3021285CD1DC" modified="2022-01-19" version="1">MSCTQAYARIPLGKNSRFILSCRAMHQSALLKAAAPGKQPAKNTYSPTLLLPKTPFPLRADAAKREHMFRDRCTKDLYQWQLKNNPKELFVLHDGPPYANGDVHMGHALNKILKDIIIRYKVLQGHKVHYIPGWDCHGLPIELKALESLKSTESKKMKPSDIRRVAKERALKEVEKQKADFMSWGVMGDWDNPYKTLDKGFEIRQLRVFNEMVKKGYIYRQLKPVYWSPSSQTALAESELEYNDHHLSRSVYVRFPIVEAGKALESIKRNSASPLYALIWSTTPWTLPANRAISVHNDLIYTVLDVKTKESNNETYIVAKDLVESVLAKLDAVEHNSLGEITGADLVGATYKHVLNGETMPVISAQHVTAESGTGLVHTAPGHGMEDYEACRELGILPFSPVNGEGYFTADAGKQFQGLFAFEEGNSAVIDYLKEVKGLVKEEPYKHKYPYDWRTKKPVMLRATAQWFANVGDLQQDAVKALGDVRMIPSVSSRRLEQFTLSRKEWCISRQRAWGVPIPVLYNNEDGKPLLTDTSIAHIIKMIDEKGIDSWWTENDDMLFVAPEYKTNGEKYFRGYDTMDVWFDSGTSWTLVDGLEGRSVIVTRLVMPLLRSLTQHFVETLPSLLPIFIWKEATNIAAGSNRLFAVKSKSPYSTLLTHGFLLDERGLKMSKSLGNIILPSSITKGGKDLKKNPAYGTDILRLWVASTEFTRDVSVGPNVIAQVSEVMRKVRTTVRFMLGNLSDFDSTKAAPYEQLKHVDQYMLHELNRFTDTMTEAYEAYNFNGAMQALQNFNSNALSSFYFDVVKDRLYNDTKDAMTRRTAQTVLAAIVNAYTLTLAPVACHTAEEIYEQYKSLTEQPQSSNSQWNNPTVKAEYDLLRSVKGEVNQALELARQDKTIRSSQEAVIDVYCANPSSETAAILQKYETELASLFLTSDAKINLKEAATVSKGYQRECAVVNGDNIIVTAQPAVLHKCPRCWNYHSEKDNTLCGRCASVLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UE25</accession>
    <name>A0A8H7UE25_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ketol-acid reductoisomerase (NADP(+))</fullName>
            <ecNumber evidence="6">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Acetohydroxy-acid reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">INT43_007183</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="6"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UE25"/>
    <dbReference type="OrthoDB" id="10255643at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000003">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000167">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371:SF1">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14 17" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="12 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="18">
        <location>
            <begin position="62"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="19">
        <location>
            <begin position="251"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG2182256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="399" mass="43926" checksum="99909BC576F79802" modified="2022-01-19" version="1">MSARIFATAARTAVRSAAPRAFAVQAARPMSLLAKSVQTTAVKSTIAQQVRGYKTLDFGGTKEVVYERSDVPREKLLETFKDDTIAVLGYGPQGRGQALNLRDNGVNVIIGQREGKTYQQAVEEGWVPGKNLFPVLEATEKGSVVMNLLSDAYQKAIWPEMAPLLTPGKTLYFSHGFSVVYKDQTNVIPPKDIDVVLVAPKGSGFTVRRLFQEGRGINSSFAVFQDASGKAKDRTIALGVGIGSGYLYETTFSKEVHSDLVGERGVLMGAIQGLFQAQYEVLRANGHSPSEAFNETVEEATQSLYPLIGEKGLAYMFANCSTTAQRGALDWWKPFYTASKPVFEDLYESTRNGSETARSLDRNSKADYREKLEAELREISDSEMWRAGETVRSLRPENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UE58</accession>
    <name>A0A8H7UE58_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_005372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UE58"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="117"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2176139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="343" mass="38426" checksum="C9FCA4BCEFB0375E" modified="2022-01-19" version="1">MPDNYMPSWLSYTLSATGLASAAGGVMLYLYQSDLLYLPSHPDGSRTQVPKPSEFGMPYQEEILTTKDNVKIRSYIIPQQDEKAAMNAPTIIYFHANAGNMGHRLPISKVFWEKFKANVVMLSYRGYGLSEGTPNDKGLRIDSQTMLDHVRAHPVLGKTKIIAYGQSLGGAVAIDVVARNPDAFSGLMIENTFLSVNKMIPHVIPMLKNLTWLCHLNWPSESSIRQIVKTPILFLSGKKDELVPPAHMRALYETSQTRGLKVWKEFENGTHNDTCIQSGYFSAIRDFLLEIRDDMPEPAKEEAAATKEKTHLSEQDERFQLVSGVADADGMTHSFRVEEVDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UE92</accession>
    <name>A0A8H7UE92_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_005478</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UE92"/>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Small ribosomal subunit protein eS4 central region" evidence="8">
        <location>
            <begin position="106"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Small ribosomal subunit protein eS4 C-terminal" evidence="9">
        <location>
            <begin position="223"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2176244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="272" mass="31057" checksum="32F8B2267B7757F8" modified="2022-01-19" version="1">MRYVNSHETTTQLAFSFPYELLGCYAVKASGGPHKARSCLPLSVFLQNRLRLTIRHDNREAKLILKQRLVKIDNRVRTDMAFPIGFMGEVFILIWTFIDVLSIDKIGEHFRILPDIKGRYTVHRISEEETGYKLCKVRKKKLGGKAIPYIYTYDGRTIRYPDPAIKVNDTVRLDLNTNRILDYLKFSVGMLCMTIGGRNIGRVGSITHIERHMGGCGIVHVKDGLDRPFATTTENIFVIGDQKRPWVSLPKHRGIKLTIGEERDSKRAAAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEL4</accession>
    <name>A0A8H7UEL4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UFSP1/2/DUB catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEL4"/>
    <dbReference type="OrthoDB" id="288987at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012462">
        <property type="entry name" value="UFSP1/2_DUB_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153:SF4">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MUG105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153">
        <property type="entry name" value="UFM1-SPECIFIC PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07910">
        <property type="entry name" value="Peptidase_C78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UFSP1/2/DUB catalytic" evidence="2">
        <location>
            <begin position="69"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="394" mass="44766" checksum="2AB4497B2EAD5DC2" modified="2022-01-19" version="1">MAADNQTSSVSEELGSERQVIDVDYAKHYQVRDALLKTLKNLNESSRTQGVIPQLKPHFISLNKKGKTSAAYLCSPDTGHIATGLTDLGWGCGYRNCQMLMTFLQRQQHEGAPLLDMVLNIKGLQLLIEQAWNEGFDPEGAQQLRYQVYRTRKWIGTTEVYTLLTYLGIRCTILDFDKRTGPNNSHDAMFDWIQAYFEDDIEKKTDDGPSPSTNALDHLMESAKNNRPIVHITSRPPIYIQHSGHSRTVIGIEVLNDGNRNLIMFDPGHRILGTYKRKVSEPEDDMSTSSIISVINENEDAAFQPEEETTSKGVMGKLQQWTTVPPSNLLRSFRVSSKTIAKNKQYQLLVLGEVKQESHPDKKFKNLYWNRSAGYLLDAQEREQRKKIGSFRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFA5</accession>
    <name>A0A8H7UFA5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">INT43_008455</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFA5"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16858">
        <property type="entry name" value="ING_ING3_Yng2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF103">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="4 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="16">
        <location>
            <begin position="216"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="157"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2180875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="279" mass="32197" checksum="CCE0508B015F993C" modified="2022-01-19" version="1">MDGLDIRHDSNLYLQEYISTLENLPSEIQYHWAEIQKRNEQLEELERHIHSRDNNLSKIHRQVMNSTDTKADALKNEPIIIRKIRRDYDRIQALADEKVQIAEEALKLLERHLRRLDNDLDKVQDDSRTDMGSPPSMMSTRQASPVAALKLPLADMIGEGSQRKRRRANSNVSSGRSTPAIRTRSRETTPLRGPRRQHAPPRHGNDSDSQGESDEPLYCFCQQVSYGNMVACDGENCPHEWFHYDCVGLTAPPKGAWYCEHCLAEMQDKKVKKLKRKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFE8</accession>
    <name>A0A8H7UFE8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_006767</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFE8"/>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="UBA" evidence="9">
        <location>
            <begin position="271"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="587"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="311"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="423"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="736"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="887"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="487"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="542"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="743"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2183756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1096" mass="122203" checksum="C17761900805570F" modified="2022-01-19" version="1">MDDLSDLVWSDAQKKQPPQLPKKPANLSSQTSSSNKFSDDAFGNLVDFRGQAKPDISKLSLAEQQQSSKSPSPFAPSYSGTSPLRPQRYTPSQPSSGYNSDAQTLLEPTVRRPTQTSTTNNTSGADAFDSLLDPLGEFGRGSGTKSPASSLNALRSQNSTPSNFSDKGGSTNQRQEHQWDLDLLDQTYGKSPVRSSSASPAPLDPFDMDPFEPSPRQQATSSPAWSNEVADDIDNPLGILAEPAKKIQEKKSPPPASPMSSPIAPRATSPRANRDGLIQQVIDMGFSRDQAVNALEATENGTDVAMAIDLLLQDREAASPQSRSSPRESQRQRPQRQQQQQYRSPTEAARAKIWDDEPQQRATSPSSRQQRPPRSHHDEYEASDDSKQPTFQDQKEKIVTQASELGGYLYKNASLFYKSSRQKVSKYMQEMQVENERARSRGDGSPSKPRWMTDAGEDYNEDNVKVPPRSGKFEKYADESSDEDPESERQKEEEFRLERERQRKRYVAEQKANQTKQKQKQHQLLDTADTYVSPSRRRGPPSGQTSGRNSPQTAPSPRVTPTPPVANVRRRPARPVVEASPSQLEGANSHKQRGNEQFKLGQYSDAEQAYTQAMSYLPQRHDHLIILYNNRAAALFKNGEYKRTIEDASSAIQLIGQDYLDDTTSLTIQGVQVAMRDQAMKALSRKAQSLEHLEKYADAIIEYNTLLRIDSNGKTTSQTQQGLARCRKSINDADKIEQASKRQAPSSNGQSSAGSSNPFSVDFDPITAAAAAPASVRASSVSKIDVDKSQAVKQMRANAAKQSAEEEERLKITDDVDRRLQAWKHGKENNLRALLASLDTVLWPEATWKGANMSELIDPKRCKIVYMKAIAKVHPDKPQNEYIEEHIKRHGRRLDYAERNIKQHEEKNAKQKSADAVPEGAVPTYLLDREGEQRAKILSNMVKQKRKEKAGKWNVPLPKVRGIAEDEMFKVMKTGKNKTKSWKRLVTKATFVGEGFTRKPPKYERFVRPMGLRFKKAHVTHPELKATFQLPIISVKKNPQNPLYTQLGVITKGTVIEVNVSELGLVTTGGKVVWGKYAQVTNNPENDGCINAVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFX7</accession>
    <name>A0A8H7UFX7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFX7"/>
    <dbReference type="OrthoDB" id="2258222at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="108" mass="12438" checksum="56F52C06B27F6323" modified="2022-01-19" version="1">MNEHSMDKSEFREHGGTKTSQIAHAEAAMMAGKAYEVRNHEGHNKQYDTFEDYVNSGDHEKHEGQPSRGARIDRELEQQDQKLVAQKEAKQAQKKEHAAEHHGHHRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGB4</accession>
    <name>A0A8H7UGB4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGB4"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2182000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27594" checksum="E65F032A6565FFAF" modified="2022-01-19" version="1">MARVAPEHIPLTTEEPIESRQLRNALKDINDVTELDPNVMEAVLLPKPNPNEFPTPAELLQDTNGELASRLLQGADMQQPQVEEEEEDEPVDPQLIEFTEKNKRVALEEFAERPLVRSAKSVRKRKCLVFQDPPIVVTQPQRITVTMFYGVLPPDWDAGITSPTQSIDSPSVPMPRIKPPSKSRRYLVACDFSEESFFAIEWTMGTLMRDGDEIHLVTVVNREDNPELVEAAGMTLTKEVSRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGJ1</accession>
    <name>A0A8H7UGJ1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Centromere protein Chl4/mis15/CENP-N</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_007152</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-N/CHL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGJ1"/>
    <dbReference type="OrthoDB" id="6585699at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052011">
        <property type="entry name" value="CENP-NAC/CAD_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007902">
        <property type="entry name" value="Chl4/mis15/CENP-N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46790">
        <property type="entry name" value="CENTROMERE PROTEIN N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46790:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05238">
        <property type="entry name" value="CENP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2182225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="45978" checksum="A09F694B4690BC77" modified="2022-01-19" version="1">MLQAGSTTRYSPAIVPWTDSLRRLLSKHSKETLLSVVEEWFRHTDTLPHGKADDDEDDGDEQIIEVGTLADYEALRQSQVHNIANRIITMDWPKGLTHDQIAMLDLVWLQNRYLTGRTWRVWRLKSDEHRPDLHVHMEPAELQARMRRHFTAYFSRCHIYVSACTLHPNTREETPTIWIRISFYDTSPSIPSNASNIYLVQFPGSDTILCGSNIRPDVKQFVLQVLVETFNAASLWEQDLKSKHISSLYQLTLYRDAQGPWSQYRLNEVDANPLAPPSKWPTLEQNKYVSGREASRRIQPLPSSAVNERLKVVKSKFGNSQLVGPERMFVKIRMPLRGLPDDRLWDCKLRFDGKNVAEGLKQLLAKGAIDASIMPEWLTDISSTTTNTITITPEGLEDQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGK6</accession>
    <name>A0A8H7UGK6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007197</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGK6"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF15">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 12 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="359"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="522"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="296"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2182270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="857" mass="95987" checksum="3FD63FE5CBC6BBB4" modified="2022-01-19" version="1">MSHHLDRTPSQEETENSFSELSLDDGEKGLSVEDLDDSFAAVDLQSTATDLSGQDACHLDTQELRKETNGLAKSSNRTATPTMGADDVLDDLTSSLDSPGKAPARAETPSPSQSRQRETDPGVRARYYSTPESRYEHLFEEVSLDLPRDPNPITASPTPSKLFKFIARKPSPPTNSRSTNLLDDNRFAESNDEISGPFYSISDVLEDRKAVVGPRSGGTISAPKLTSAQGARRGINQNDVVATSGGSSAKALKRRSSLNPFSRPQKQTPSALEAVISKTRPNMLPPKNPSEEKKHLQQHESMMKRAKAVEAKKEKQINKKREERNKQVVQATRTWEEEILPNWHTKRQERRTQDLWVQGLPPRCRGKVWNLAIGNALNIPRETYYMYVKEHPKLPTDMTSESTTDGYKYHNGKRLSTSASSVDGNKTINSSKSYHQYSKSGGDLPSSNTHFEPFDRSKLGSAGDISYHRKGRTSSLEVLKSDDNQSVSSKRFSTTASSVSDMDEHENNAVKSFVMERQFVDDEPTNSPYDVLERQASPATENNNGIYNEMLRDGSATSSAFRNDDDMSDINIENEEDGDSDDFEEITGDHHNSVERSDIKEDHLDRSPDSENEAYNNKVITEDILRTLPSLCVFQNHKVDGPMYAPLREVLRAYTIYRTDVDYIRGTSFLAGMFLLNMDADKAFVSLCNLIQKSPVLSAMFSASENGIRNYAKVFNVLFAENLPKLYLHFRNLALTPNNYLTDWLTTVFASVLPLELSSRLWDIFILHGDIILFKTGLVMLKYLEPLLWGGSYGETVRTLNMGFVGEERGEELNAVMAVSGNITQGEQDRFFDEVMGRGSIRVDESKYAELIRVHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGL5</accession>
    <name>A0A8H7UGL5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_008502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGL5"/>
    <dbReference type="OrthoDB" id="1845550at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2180922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="64" mass="7172" checksum="B44B7A31BF532078" modified="2022-01-19" version="1">MSTAQNKVFGIGTMLGAGMEALLIQSNYYQMLAASEAKARKKKQQEELEDIERFQSMSQSNPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGN0</accession>
    <name>A0A8H7UGN0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_007275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGN0"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034842302" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="21"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2182345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="554" mass="60549" checksum="F26E370BCB9DBA7A" modified="2022-01-19" version="1">MKALFYTSLVALTGLATATSPTAKVKNGTYVGTHLPTFNQDMFIGIPYAQVPTGDLRFRPPASLNTSWSDQKPAQEYKNSCYAFGPYTDNDGITQSEDCLTLNVVRPAGSSGGKLPVGVWIHGGGFTQGVSFRDVYNLSYPVQQSVEGQTPVIGVSINYRLGPFGFMASSEVKDEGSMNAGLKDQLMALRWVNENIEAFGGDPDKVTIWGESAGGESVAMLLMAYGGKLKNLFRGAIMESGSSTTQQYYPVSHWQAQYNNITNMVGCDGDKDTLKCLRSVDINKLVHVVNITNGLISQTYGPTIDGDFIPDWPKSLLTEGKFVKVPMISGANLDEGTSFGPGNVNTTEDIQTWMEKSVPTLSKSTIKTILKLYPNDPSKGSPYGTGDLYDNSTFGLQYKRGASIGGDTVMIGPRRLMCETWTKAGEKVYSYNWNQSDYGTAPQAGSTHFQEVVYVFDNPSSSFPTSKAAPMGPDPTGDKKQLGDLISRFFMSFIATGNPNKAKQNGKVSPWPAYDIRKPQNYYFQAGDSHPEPDTWRKENINFINYGVGHQFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGY7</accession>
    <name>A0A8H7UGY7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_008910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGY7"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2181327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="128" mass="14679" checksum="4F18565E4CE18C43" modified="2022-01-19" version="1">MIPLSPFLFANQDDYEADNVEEEPAAIDESRVDILEDVMNGGETGDVQETRERVTTPYMTKYERARVLGTRALQISLNAPVMIELNGESDPLVIAMKELREKKIPLIVRRFLPDNSYEDWHVKDLIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UH80</accession>
    <name>A0A8H7UH80_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor G, mitochondrial</fullName>
            <shortName evidence="9">EF-Gmt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Elongation factor G 1, mitochondrial</fullName>
            <shortName evidence="9">mEF-G 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Elongation factor G1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MEF1</name>
        <name evidence="11" type="ORF">INT43_001914</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UH80"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04097">
        <property type="entry name" value="mtEFG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04091">
        <property type="entry name" value="mtEFG1_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000003">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000029">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000022">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000015">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047872">
        <property type="entry name" value="EFG_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009381">
        <property type="entry name" value="PRK12740.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636:SF2">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="72"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="81"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="148"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="202"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2179064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="766" mass="85096" checksum="0559862713AD84F9" modified="2022-01-19" version="1">MSFVRNLWGALPQKATSYGATAVKLASAAPKRPLNIFPSVLQQRFQSTYEFDPALTATTGEDANADDVARLRKLRNIGISAHIDSGKTTCTERILYYTGRIKEIHDVRGRDGVGAKMDSMELEREKGITIQSAATFAKWGDYNINIIDTPGHVDFTIEVERALRVLDGAVMILCAVSGVQSQTITVDRQMRRYNVPRISFINKMDRAGANPFRIIDQIRQKLKLSAAALQIPIGSEDQFQGVVDLVKWKAYYNEGERGETLAIKDIPEELLELATEKRHELIEQLANVDDEIADIYLLEEIPTAEQFMTAIRRSTIALKFSPVLMGSAFKNHGVQPLLDAVINYLPDPTEVTNTALDAANEEKPVDLAPFSNHPFVGLAFKLEEGRYGQLTYMRIYQGTLKKGSFVTNIKTGKKIKVPRLVRMHSEEMEDVDELGAGEIGAIFGVDCASGDTFTDGTLKYSMTSMFVPEPVISLSLAPKGKETPNFSKALNRFQKEDPTFRVHVDKESKETIISGMGELHLDIYVERMKREYNVDCVTGKPQVAFRETIQESSKFNYTHKKQSGGAGQFGRVMGFIEPMTAEEEGGKDTEFDNRVVGGNIPTNFIPACEKGFRDALDKGPLIGHPVNGVRMVLEDGAAHSVDSSELAFRIATRAAFNDAFAKARPVILEPVMNVAITAPIEFQGTVIGGLNKRKGTVVDTEIQEDYFNVTADVALNNMFGYSTELRSATQGKGEFSMEYKDHQPVMPYVQEELVTEYKKKQQQGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHG4</accession>
    <name>A0A8H7UHG4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Vacuolar fusion protein MON1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002414</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 3">Prevacuolar compartment membrane</location>
            <topology evidence="1 3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MON1/SAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHG4"/>
    <dbReference type="OrthoDB" id="272411at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="5">
        <location>
            <begin position="104"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="6">
        <location>
            <begin position="264"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="7">
        <location>
            <begin position="398"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2185976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="509" mass="57814" checksum="BBA62E37AB736864" modified="2022-01-19" version="1" fragment="single">NARRHKIGESCSSPHFWSQMSSIKDQPISNDTEASDLSTSYDSNSSVESSLSDNHKMYNKLKRQGSRSSVLASNSNRSISKSIDTQKQVALEGPDTKTWSRHKKHFFILSSAGKPIWTRYGDESGTSSLMGVIQAIVSFFQDDDDSPRCMNAGHHKFVFQLKGPLYLVAVAKTGESETHLRDQLLYLHSQILSVLTSQQLTKIFEQRINFDLRRLLSGTEIFLDSLSTLFNNDHGFMLGALQCLRVSKILRDQVGNALAEGRVKNLLYGMIVSNGKLVTLLRPKKHSLHPSGSHNLHLLFNMLTGSTTFRTAESWTPLCLPKLNSKGFLHAYICYIERDTCVVMISTNKDSFFDISDWKRQIVEVRDNDDKLTKSEALAKLQKAADDSYSASDIGIPSLRHFIYKSKLHVQFTCPELEAPYTNTISRRRLYRLYQRTHDRLHSKTRPLKLYYLAGSHETVLGWITSSFELYVVFGPNVPNSTVITSSNHLLRWIKKHEDLLFILNSPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHI5</accession>
    <name>A0A8H7UHI5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_006867</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHI5"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF24">
        <property type="entry name" value="HEXOSE TRANSPORTER PROTEIN (AFU_ORTHOLOGUE AFUA_8G04480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="42"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2181942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="518" mass="57588" checksum="781FC01D8BEFCBCC" modified="2022-01-19" version="1">MKTQDTEGWNGTSTEATLIRDVIPKRTKLWWHYPALRTLNLLLICCIVTDITNGYDGSMLNGLQIIDSWKEFFNHPSGSILGVISNGTRFGQIGSLFVSAALIEKFGRRRPIAIGSVILLLGVILQTAAVNTTMFVLGRVLIGFGNGIQATACPILVAELAYPTQRTQITGIMNSTGSLGSLLAATITFGTAYLGSSTWSWRLPSLLQAMSSILQLALSFYVPESPRWLVHNNRRDEAWKILAKYHAEGDESSELLKFEMDEIDAAIEREKAQSLTSWMEWFRTTGNRHRFFIVLTIGFLIQWCGNALISYYLTLVLKSIGITDTRTQLTINVGININGMFFGNFFSLWIERVGRRPMLFMGLTGMFCAFLILTVVTGINQNADFHNSAASQTSLAMIFIFGAFYKMAGPVCPSYVAEVSPYDLRAKAFVINGFADAAANVFNGFANPVGLTAIGWKYYIVWCCVLLSNMVLVYFFYPETKGLSLEEVAIKFDKDQAETIQREPAEKEAIDAPLEPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHK5</accession>
    <name>A0A8H7UHK5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_006928</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHK5"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF3">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="380"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="554"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="567"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2182002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="585" mass="65764" checksum="B5F2A39CBEEA2D14" modified="2022-01-19" version="1">MAWSTAIARGNRSSPGLSTGPNGHSSTSAGSQPMPLVSKRYTQPCRATGDSLACLVGASMTVVGQSVLVFGGFDQYSDEVYNDLYQLTNVGGRYKWMNMLYIKGNRPSKRNDHSAALWQGDKLVIFGGSSDDEVYCNDVSILDLSTWTWHQPQIQGNLPWGRMKHSATIHNDKLYISGGLCSGQNFSDTIDILDLKTWVWLPSIPFVRRCQHITFFHGNRLYLYGGLAEKMDRSHNISFINFDTYQVTELQVNAPETPSLAGQHFAQVCGDDLVVVVTNPIKQVVSESTTGVWSLDLTSMTWRRRGGGARFDSGQWHYFSMAEHDTSFYLFGNTEEEPEEYYSQILKVDLQEHGIYAVPPPQMGSDLVQMLVSETGRELADFVITSNEESAPPIQTHRLILLARWPHFENILQSGMAESVSRHLRIPEPYSVVNAFVTFLYADSIDQFDIDLVSDLLVMANIYMLPRLLALCARRMHAHMDIANVSKIYHCAGVAAQRGLQQTALNYMFEHYGDVSRTIGFRDLPKEVLLDFWDHTPSNAIITTKDMMLIDRNDEPVHSAPTSYPPGEDDEDDEDDVDEDEEIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHL3</accession>
    <name>A0A8H7UHL3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHL3"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000016">
        <property type="entry name" value="TBC1 domain family member 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="100"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2186141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="389" mass="45228" checksum="D7512761E5661E92" modified="2022-01-19" version="1">MYVRTTSSPRQSIISHSRKSSRHRQLSNCSPCSSEGLEQYDIYGFNKSSQHVPLHRINEFEARYQSIMGHKRYQWDQMLAENGGDWPEKSPKLRRYIRKGIPRCYRAQAWFHYSGALGLLQKNPHVYKSLVQSAEMMGSHNEHRNLIEQDLHRTFPDNQHLRCQRPEIHSYEPYSPACVPKIQSLRNVLMALSIYSPAIGYCQSLNFIAGMLLLSIEDEEQVFWVMVITTSHILPSNTYDITMEGASIDQLTLLWLIFDKFPEIWSRISNDVPFWELEQYERPPPSTLVTTHWFLTLFANVLPPEASPLITVFRVWDIFFFEGHVVLFRVALAILDLNSEALLNAEDAMEIFQIMQILPKQAIDCNQLLDVCISLSYLGYDLLRLILEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKF3</accession>
    <name>A0A8H7UKF3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 12-like conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_002863</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKF3"/>
    <dbReference type="OrthoDB" id="2192888at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057860">
        <property type="entry name" value="HEAT_RRP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25772">
        <property type="entry name" value="HEAT_RRP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 N-terminal HEAT" evidence="6">
        <location>
            <begin position="13"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="RRP12 HEAT" evidence="5">
        <location>
            <begin position="322"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="967"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1204"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="967"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1014"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1025"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1068"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2186425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1223" mass="135661" checksum="2DED5C9AA2B9C62B" modified="2022-01-19" version="1">MEAKFSKIRTQINSKLENQKQYAGTLIAIEEALAEQNAPLTPTGYFAAMMAALQSSAGSPQTRGCLLYLLDQVFPELPQSVLRQKYTDVLPILIAAMEEDAEDQPVVRSTVGCIEPLLIAQDGSVWNQIVTKKAYQALLLMSVDGKPKSRKRAQDAVKTILASPPPPTVQHPASNLTADFTLKVLKEATKTDQNAAQKLLALLKSIVPFWPSSQFVSLCQMLLHLPKFNNPYLTQASFEVFEALFSAESISFDDEKFAQLLRSLCELKPAGIDDRLLPTWLMVITKAYPAFAKINADLCASEIVNVFPIIFQDLEVASNNHAIIAGCLSVLIQYCITDNMIAEAQQANNTPLHHIIGTVENGLGIRYQMSWVHVMTIVQALFRRLHRMSSPLLQQCLSLLGDLRLSAQETYKEQLDKTLGAAIATMGPEAFLNILPLNLESPSSSGSIGRAFLLPLLIKYTTNTSLAYFVNVLIPMADRLSQKSETFASQGLDLQAKVYETLVNQIWSMITGFCDLPYDLRTAFDNTVAERFSSVLYSQPDLRPTVSQALQFLVQKNQTLTTSAASDEDLKKAYGITKSDAERNLKHMSQFSVNYLAVFFNVYSQVPPMYRGFLAEVIKAYLQISPAEDINNTFKKVVTLLGEALANPETTPAVSDPSIPPPMSHTMMDLAIVMIPFLDFQSAELLYNGVTSALISKEDAPILQKKAYKVINHLASCEVGTQVLKKNIETLQTRVLEGTITCAVSSKKDRIKALGNIVHILPTNDLHLIPSILSEAVLATKEVNEKTRGFAFNLLVEMGNKMKEGGKVVNSKIEGMDATAPDVDANITEYFTMVTAGLAGSTAHMISATITALSRLFFEFKEMLPSQLLLELLDTVEVFVNSNNREVVKSALGFVKVAIVTMDSMVIGQHLPTVIGGLLNCNKQHKSHFKSKVRHIFERLIRSFGYDQVAELVPEDDKRLVTNIKKRRDRSKRAKNANRGEEDEDEEVETTTRQAKTVRTGSDAYEEAVYGSESEIEDSDDDNMEGVRESSGKQDKRSKKAKMVTEAYIREDGDGPLDFLDRTALASKPQQRKTLAQRSTSRAEAFQSGDDGRLVINDSDDEPTKAEAGNGEENEAENYYMQAQNSADGFVRGQGNKIKFKKRGNQSMFDDDIMEVDDKEKRSKKKIERKMDVIGKEYRSKRAGGDVKVKGKADPHAYVPLSKITKKKGRHGPGMTFTGKYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UL46</accession>
    <name>A0A8H7UL46_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_006799</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UL46"/>
    <dbReference type="OrthoDB" id="2382073at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008710">
        <property type="term" value="F:8-amino-7-oxononanoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF100">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="4">
        <location>
            <begin position="40"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2183788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="377" mass="42775" checksum="5EF01A6AAD8720FF" modified="2022-01-19" version="1">MERHVEMVDNYFKCRTTQGNGVVKDYFEVTDNAASIFVCGNDYLDIANNTHVINQQIKHMKTDVEDNFRSGTYLRETDPHSRFEKEFEVYFGKQCTLTQSGYAANTGLMHALCEKGTQVYIDKFTHASFYEGLYLKGAKIHRYKHNDLLELESKIKRYGPGIIIVDSLFSNLGDFAPLKDIVSLKIKHKCVLVVDESHTLGVYDKRGLLHKLGLGADVDYITASLAKAYCTRAGIILGGNKAHIKEHSLWYIFSSPLLKYDVIRLLAMFEVIKNADEKRHHVLKISKVVRKGLATFANVIETSQPSPIICIRFSDENECARLHRYMVSKGVEASVFIWPAAPLKEPMLRITVHNGLTLVQASFIINVIRSYFISAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UL62</accession>
    <name>A0A8H7UL62_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_002249</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="565"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1039"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1132"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1203"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1231"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1315"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="331"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="724"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="1055"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1411"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="685"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="685"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="724"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2185812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1689" mass="190388" checksum="912D264D84BF4E3A" modified="2022-01-19" version="1">MRIVYHYCGSDLTLEDPFTSDGIDFTACFRESVFDVLLPFLFVVTSLALYIYRRYSLSHESPCIDISDADFLRLPTQKVHTVRGLCHLAGVLTQIGSWAFVFAWRLESSILEHHQNPSTYDTPLYEIICPALSLLPWIYVLVMVIKLFIVSSNPVAPSKVTLYNPHLLFFYTIALLGSVIRLRSNLLNSDNSSSAENTLEILTSALSTCICTALFLVSATTPREIDREELLDIDDSDGSVMILKDGRVLRNGRLLTPEASASILSSIMFNWMNPFLTQLRQAPTVYAEDLWALTRHHRAKECHRDFENIEHGIGPFGLLYQIYQSNRHAIWLQCITSLGAVLSHYSNPFFLDKFLQYIQDPAGRPMQSAYLYCLGMFAGSVINTLFSSQTLLWGRRCNVRMTNMLNAEIYAKSLRRKDVTGFAKSKDEDGDEGDEQVVSESTTGKITNLMSVDAERLAEMSSYIHIFYSCPFEIIIGVVFLYRMMGNAALFGLTVMIFSIPVHHYMGKKYNRVQERLMAARDRRTELLNELLHGIRMVKAFAWERKWEEKILRARRIELDRFVRVYIMNTCVGLVWFACPVLVTVVSFLWYTKVEGHELTASTAFVSIVLFGMIRDPLNVIPEAYMSYIDAKVSLTRISDFLGEVERGGELKGSKVVLSSYDSFKNSQQSRCGFDEGSFQWHSKDVKDNRATGKTDDVKTIDEPSVTTKGRQEPRETDPLLPVTSSDDITSYSSSSSTLTSATSTYQMSNFVLELPNITFPSGKLTIVFGPTGCGKSSLLNALLGEMDALSGRAWLPSNYNWNKTVTADKYALDSVDSGLYTYKVAYAAQQPWIQHASIRENIVFGQPFDEIRYNKVLYQCALVKDLEILEDGDLTEIGEKGINLSGGQKQRVSLARAVYSRAKTVLLDDCLSAVDANTASHLFEKCLLGDLMHDRTIVLITHHVRLCVGGAAYLVQMSKGHIARHGYVEDLRTSGELGQIFGDDDIPDHSMDNLDDGGIYTDVESDNSYAGSDVIRNVPKKLIEEEVRQIGTVKAKIYATYLLACGGFFFWGTLLFFYIISRLSNIAENYWLKVWSAAYDNKGNCHNTTMLESSIFPGVSTALYSMSSAVTFGYKGNEECTKEPVSVNYYLSVYVLISFGAIVISLFRSLIQYYGSLRASRLIFHKLLLSVCHAPMRFFDTTPVGRVLNRFSKDMETIDASLSWHATFLLQTVLGITAVVAVISAITPEFLFASLIIGIIYIFIGTYYVRASRELKRINSVTRSPIFSQFSETLVGVTTIRAYGQEAPFMNEMLNRLDENMRSYYTLWTTNRWLFVRVEMTGSLVSFLAGVFLLRNLDSIDAGLAGLSLSFSSTFLEHIYWLVRQYTTVEMHLNSVERVQEYLEMPQEPPGINEHNRPPPDWPYEAAISVRNLEVSYAPGDDPVLRGISFDVKPREKIGIVGRTGSGKTTLTLSFLRFVEPLRGSIVIDGIDIQSIGVEDLRSKLTVIPQDAILFSGTIRVNLDPFDEFSDAEIWQALRRVHLAPNSSSFLLQLDESDEDDSKVITSLDTQISEGGTNFSQGQRQLLCMARALLRNSTRLIVMDEATSSVDFDTDKKIQTTIREEFSESTLLCIAHRLRTIIDYDKVLVVEEGKIVEYDTPYNLLLENSGVGLFKYMCERSWEYDHLLEIATKVEMAKQARSANQTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7ULM0</accession>
    <name>A0A8H7ULM0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_006329</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7ULM0"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002112">
        <property type="entry name" value="Leuzip_Jun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00043">
        <property type="entry name" value="LEUZIPPRJUN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="249"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="340"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2183324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="385" mass="42453" checksum="C638293D6B8281CF" modified="2022-01-19" version="1" fragment="single">MTSTSMLPVNGSESQDGILSTPTRFLMECGEWNFTPSLSNFGNEVNPFDYIGVQKSKEGNAAAKQESPLTPPSANATDKQNTKGEVAMAQPTPPQPNKGEEKRRPQDALRAKVSSNASLDSESSASSGESATGMKALTKAVEIESQQLKKQRLQQQNTRPRSQRGQNQQYSFHSYQPTQQPRHTAMPTTHNSSTLIIKQENGQPNSKNRRNKDKAAAAAAAAAAAASNTSDLSMTRKRSNPEDDNDEGSDRRRKFLERNRIAASKCRQKKKAWVNDLEGRSELVLEDNKRLTTMVAQLKEEAMFLKNQLLAHGNCSCDVVKQYLQQNTKFADQASNVTFQPPQQQSQMLPPPPQQRPKQTGEDYFAPVHSTPTPSLPPLRATAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7ULZ8</accession>
    <name>A0A8H7ULZ8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_000586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7ULZ8"/>
    <dbReference type="OrthoDB" id="20669at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF12">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2184673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="26211" checksum="59B381232850796D" modified="2022-01-19" version="1">MACRNNVLIVGGNSGEFALKRVDEKDGTEHWGAITSDASGITNHIDLVHDRNGAFQALISSNDFRARLMDINTSKMTREIDFPWAVNCSTLSMDRRILCAVGDATESIIADAQTGKGKRLYLATGNQDKTTRIYDIRNMSETLHVLRANVGAVRSLHFSSDGRHLAVAEPLDFVHIYDATTYDQSQVIDFFGEIAGVSFTPDDNSLFIANADDRVGSIMEFGRINHGCWQDDDCFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UM31</accession>
    <name>A0A8H7UM31_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_000691</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UM31"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="106"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2184778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="292" mass="33005" checksum="6AB560B14E2A8690" modified="2022-01-19" version="1">MSLHSVKEYLRKRKATILSYLKDWILVIIFLVIFLAIANDISNADLLPPFHQEFYVDDWSIRYPYSATERVNLTALLIIAIVAPFVIICLIAGAIKRSFHDLHNGVLGLFFALTFTLMFTDVLKITIGEPRPDMLARCQPSPNTQSPAEALLNISVCTTPYDSTFQDGFKSFPSGHSSFSFAGLGYLSLYLCGKLHVFDHKGHVWKGFVVLVPIMGAILVAISRIMDYRHHPWDVVFGGLLGSLAAYFSYHQYYPPLHANDCHLPFEPRHHVKLVSRPEDETQSAETPHNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UPK8</accession>
    <name>A0A8H7UPK8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino-acid acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="5">2.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Glutamate N-acetyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">N-acetylglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_002792</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">N-acetylglutamate synthase involved in arginine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.1" evidence="5"/>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UPK8"/>
    <dbReference type="OrthoDB" id="5585968at2759"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF4">
        <property type="entry name" value="AMINO-ACID ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="352"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2186354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="514" mass="57191" checksum="973FC09C362C195D" modified="2022-01-19" version="1" fragment="single">SSHDSPNTHIKCTKNDEKDLILKVMSTVPSQRELRHFLKRYVPQDDSKKNTNLTIDGMQQTSTAQRSTKDIVNDLFQSASNHIALTKIQGPYAKKGWNSVASTLIKLQRLGLSSVIVLDSVEWRNTLGNGELRQRMFMESMALIEAIERQGGRARPFHIGIFETVGRNVDVYTDMIQSTLDNNQLPVIIPIMSGEDGAQKPITADLAMVTLSKKLGTSKPTGGKNMVPAKIVVINHEGGIPNHETPGTAHSLINIQEEYDGISSAYAENTSWHETHPTAIENLTMIQKCLENLPQTSSAIITPIKSLPSALITNLITDKPLYSSSLPVNSSSTAGNHSSINISRTTVLRHGTPIQFHKTIDSLDLGKLTKLLEASFGRSLDENGYYARLRKVLGGAIIAGDYEGAVLVTKETTSHQHLSSFYLDKFAIAPHSQGMGLTDILWKKMHDAWPELMWRSRKDNGVNKWYFERSDGFIRLQDSNWVMFWYGSNMYKNATELSTITRNIPASFYTASSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCF9</accession>
    <name>A0A8H7PCF9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_002922</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCF9"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF24">
        <property type="entry name" value="HEXOSE TRANSPORTER PROTEIN (AFU_ORTHOLOGUE AFUA_8G04480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="50"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2171300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="533" mass="59345" checksum="2D710336078B8DA7" modified="2022-01-19" version="1">MTDSSNVKKTDLPDASQAPEFDFDMLLRDATPKLEKWWWNYPFLLKLNFFLTTGILVQCTNGYDGSLLNGLQSLPQWNNYFGNPSGAALGTLSSGTTFGLIASLIPAAWICDRFGRRWPIIVGSGITIAGAVIQSAAVDFAMFWIGRFIIGFGLGLMQTAAPMLLIETAYPAQRSQVTSLYEISFPLGALIGAWVTYGSYFIQSTWAWRLPSLLQCFTAFIQLFLTYFCPESPRWLVSRGRVEEARALLVKHHGDGDPDSLLVRYEFAEIQEALKNEQIKKTSKWSQWFATKGNRHRLGIICFIPVITQLSGNAIISYYLHLILQNINITGSKDQLEINATLLILELAAAVIVASFCDMTGRRKLFLAGIVGMLASFVPWTALSAIASQDNFKNPALGRGIVAMIYLFEIPYHVIAPISPTYAMEIAPYELRSKASAIYQLMGQIIGLFNNYVNPIALTAITWRYYIVFCCVITLEFVVVYFFFPETKGLSLEEVAIVFEGEDAALGHAHAARARDEESSEKGEHNEKSQTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCI3</accession>
    <name>A0A8H7PCI3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_002967</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCI3"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2171345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23112" checksum="D15A39F17A5BB270" modified="2022-01-19" version="1">MIAKHSHVQESLHAEVDAVLGNPEARKHMTEAEIFAKLQDDLFAQFPYATAVVNETQRMHPIAPFVGMEAIHDTILDGYVIPKGTTIMGMSRVASMNHCPTPDPFQFKPERWIECTVTQRRQQERLDWSFGGGSRVCPGRHLANLEIVSAVVLVLSLYNLKELVRAPSSSPVAECASFLFPTFPIVTQGISFTSTINNVYVRYIPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCU4</accession>
    <name>A0A8H7PCU4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_009159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCU4"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051704">
        <property type="entry name" value="FAD_aromatic-hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865:SF2">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2171498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="143" mass="16151" checksum="46E0D8D9B0B588E9" modified="2022-01-19" version="1">MCRSHNATETQVYFALRDDSEELRIPKSPIEKQIEFWAQKFSRSGWQTDRFIEGMATTKASIARKSFMHAAYCPSPFNGQGITASLVGAFVLAGEINRNTQNLSGHLRTTKDVMTIYQRNSKRKPIAVAIWNTSNATRDFNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PE59</accession>
    <name>A0A8H7PE59_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_004797</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PE59"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="135"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2172256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="272" mass="30077" checksum="6191341D780A1D8C" modified="2022-01-19" version="1">MAGNDQRMPPAKKSTGKKVAPAPYPVKGKQTTKAPANPLIEKRSRNFGVGQDIQPKRDLSRFVKWPEYVRLQRQKAILNQRLKVPPAINQFTKVLDKNTATQLFKLASKYKPETTAEKKERLRAAAAAKTEGKKVESEKPVVVKYGLNHIVALIEAKKASLVVIADDVDPIELVLYLPALCRKMDVPYCIVKGKARLGTLVHKKTATAVAFTEVKDADKSELSSVVSAVKANYNDKFEEHRRTWGGGHRGPKSEAMMGKRAALAAKEIAARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PF12</accession>
    <name>A0A8H7PF12_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PQ loop repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_000089</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PF12"/>
    <dbReference type="OrthoDB" id="19344at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF11">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2172742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="33900" checksum="C656C8EEE26D1BE3" modified="2022-01-19" version="1" fragment="single">WNEQVLNSFTVQETICQPHHDPYALYISLFLCVGLVVSYLPQHYRIVSNKTSEGFSAWFLLLGVVSATSSVLNIILLQWDAITCCSKLSSGQCLESLMGVFQIGLQWFMFCTVFILFLLYFPDELKHAPHKPNSLHLDLPRNVERSTEWKISIAVAVICLAHFVASVLITAALLKMVGGPEHYETNLWASILGVLSMILAAFQYLPQIWKTWHRKTVGALSIPMMLLQTPGSALFVYSIATRPGTNWTSWITYLVTGILQGSLLVMCIAWHYRSKRLGIDDLHGSEEIHPTERTALLQSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PF71</accession>
    <name>A0A8H7PF71_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HeH/LEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_000150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PF71"/>
    <dbReference type="OrthoDB" id="2503928at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12935">
        <property type="entry name" value="LEM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025856">
        <property type="entry name" value="HeH/LEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044780">
        <property type="entry name" value="Heh2/Src1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN HEH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808:SF2">
        <property type="entry name" value="LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12949">
        <property type="entry name" value="HeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="HeH/LEM" evidence="3">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2172803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="452" mass="50814" checksum="CDC06131535AFDDD" modified="2022-01-19" version="1">MEDDLFYLEPDFMPSTLRAVDLRSLLLQHNVAYPMRATKPELVAIFKERITANAQEIIEKHQSANSRPTFALPQENTADTWSSGDEAPSDLIQPKSKVNEDIPTSPQKRVKEVTAASPKRQRRTKKLPIPEPVLSTPPQEEQKMLEEPLVEQNESKASEEAEKEQEGHDVSLTESDKKETFAKPAKPAPRKAKIKKPRADRSWIKPKAIHSGLTSDSDSDVGDRQKGRRRPTPKEKASSFHNFMNKGLLGLPESPNPSQENKAEPEPEPEQMEQSQVEPAVQEQEQVENHAPVQQQEQPKDTIQDTEPTSPSSPQPDNLRRSLRIRRANSSKDGNLFYDPTMELSQTEGITQEMEASENKPIIEELLTTTYETVLTEAEADDEAEPSAIALAKGKQRIKKYKQKKTKKPSPRLCQLIGLIVAGFAFWYFVSAITLPKSDKPLSEPVPTHSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PG44</accession>
    <name>A0A8H7PG44_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PG44"/>
    <dbReference type="OrthoDB" id="2224399at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2173268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="157" mass="17579" checksum="F1C7DCA4BF2CCE08" modified="2022-01-19" version="1">MPSTNTKWSELLHQTKDAPALQQFIDDLSEENAPEPTIKTFKDATYRSWPTLGISFCFTIANGEEQLDSIDIFNGRPQDKFSVYCGEHPLGLSSSSKAHEIVSALGEPIKKGGGGNTRMPCWVQYDTDQGFSVQVNLDGVHWEDREMSWTSMAIFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PG90</accession>
    <name>A0A8H7PG90_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">leucine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_004702</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PG90"/>
    <dbReference type="OrthoDB" id="15954at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07958">
        <property type="entry name" value="Anticodon_Ia_Leu_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00812">
        <property type="entry name" value="LeuRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000002">
        <property type="entry name" value="Leucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000060">
        <property type="entry name" value="Leucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000100">
        <property type="entry name" value="probable leucine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740:SF2">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="13">
        <location>
            <begin position="44"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Leucyl-tRNA synthetase editing" evidence="15">
        <location>
            <begin position="273"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="13">
        <location>
            <begin position="459"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="14">
        <location>
            <begin position="747"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2173328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="909" mass="102927" checksum="439D754302E116D4" modified="2022-01-19" version="1">MLYGMLRSTHRFTPQHCRIFGRFASSQSSRPAAGLDFAQIEQKWQKRWTENPPISPLTTGKSYYCLSMFPYPSGMLHMGHVRVYTISDTVSRFRKMAGYNVVHPMGWDAFGLPAENAAIERNIHPAQWTHDNIAAMKAQLTGLSIDLDWSREVTTCDPNYYKWTQYLFLQFYKAGLAYQKEAVVNWDPIDQTVLANEQVDAEGKSWRSGALVERKKLRQWFFKITDFAEDLLNDLDVLKHWPDRVKQMQRNWIVEILSDVLVLNTFTKDAELPEEMKELEVFTSRPDTLYGVQYLVVAPEHPLVSPSHLPQEHAEKVLSFTESLKKVQNMEDAENSKQGVFTGLHANHPLTGEQLPIYVAPYVISDYGTGAVMAVPGHDKRDWEFAKANNVLKEIKFVVDPVVTEEGQAIDRGQPYTAHGVLNSASGKYQGMRSEDAIAALTAEAQANKFGEPAVQYRLRDWLLSRQRYWGAPIPIIHCPTCNIVPVPEKDLPVELPLDVNFKGKGGSPLQQVQDWVNCKCPKCNGPAKRDTDTMDTFVDSSWYYMRYTDPHNQNLPFDYDKATERLPVDIYIGGVEHAILHLLYSRFFSKFLLKKGFFGEKPEATGNRGEPFKILLTQGMVQGQTFKDPKTHRFLKPEEVDLTDPANPKMIANGETPLMSYEKMSKSKYNGTDPETVTNRHGVDPTRLHMLYKAPPSEVLEWDDISIVGMQRWLSKIYKLASSIGATSVIPTTLDVSKMDREESKIYRFTNVTINQVTDALSVSFGFNTAISDLIKLSNFIGSSSVKPETPAYRHAVESLVKMLAPMAPNVAEESWEILSKDKQSSIFSQQWPSVDQKALIADEIKCVVQVNGKTRYTIQIPADTASNQAQVEEYAKQAPQGEKWLAGKDIHRTIMAKGGKLINFLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGW8</accession>
    <name>A0A8H7PGW8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_005176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGW8"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2173756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="153" mass="17866" checksum="1374905F2D6368A1" modified="2022-01-19" version="1">MRTTLYVAGFAPRMRARDLGYEFERYGRLVRCDIPGQKNPTAKPFAFVEFEDPRDAEDALNEMHGRYIEGHTLTIQWAKSSASSRWRQDRSRSPPPRRTPGANNRYRSRSRSPIKRSKSPRDRSPLPSERRSRYESRSPSPSRDDTRRDPISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PH14</accession>
    <name>A0A8H7PH14_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_005252</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901992">
        <property type="term" value="P:positive regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031137">
        <property type="term" value="P:regulation of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000029">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.150:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000371">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000004">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="HEAT" evidence="13">
        <location>
            <begin position="745"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="FAT" evidence="16">
        <location>
            <begin position="1286"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="15">
        <location>
            <begin position="2022"/>
            <end position="2343"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="17">
        <location>
            <begin position="2384"/>
            <end position="2416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2322"/>
            <end position="2354"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2173832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="2422" mass="276346" checksum="C983773DF229B64A" modified="2022-01-19" version="1" fragment="single">MTTVLAASNPENLDRIFTELKSKNEERRLTAAEELRDAIATAAREQPEENLTRIITDINPRIFQLIQSSDNHEKLGAIVTIGKSPRLQNYFDIGRMIFIVHIFLYCSDKLIDLEPERNADRFNNYLSSVLPYNDPSVMIPAARVLGRLATSQSTFTADLVDGQVERAIEWLQGDRSRLAAVLVLRELAINSPTLIYASVPRILDLVWIAIRDSRQLIRETAAECLSQCLEIIQQRESPQRLAWYHRIWDEITKGLRLNNADATHGSLLAMRELLLHAGMFMTDMYRDVCEIALRLKDSRDHLIRKTVVSILPTLARYDPSAFIEEYLHRCMNHLLSLLRKEKDRKDGKYYQYLAGRPIYFKRHLSICKAFVAIGNISVEVKSSMSPYLDAILMHIRETLAVRSRQRKDIEPAVFMCISMLAVAVGQALTKYMHELLDLMFNCGLSEPLVQAMKSLADNIKPLLPTIQDRLLNVISITLSGQPYKAQGAPTARATVQAVERPVRDTAAGDTKDVETIVLALTTLGSFDFTNHVLNEFVRDCIVSYLEDDVPDIRKAAAVTCCQLFVRDPICNQTSTHAIKVVGEVLEMLLIVGIADLDPSIRLTVLSSLDERFDRHLSQADNVRTLFIALNDEVFAIREIAISIIGRLTAYNPAYVMPSLRKTLIQLLTDLEYSVNGRNKEESARLLCLLVSAAQRLIKPYVEPILKVLLPNARDSSTGVASSVLAALGELSEVAGDDMIPHLDEMMPLIIDTLQDQSSSIKRDAALKTLGQLASSTGFVIEPYAKYPQLLGILIAILKTEQSPDIRRETVKLMGILGALDPYRNKTNTVSGTDDALVDPALASNDVTLLMMGIGPSSDDYYPQVVIHSLMKILRDPSLSTHHHAVIQAIMSIFKTLGLRIVQFLPLIIPGFLSIMRSCTTGMLDFYFHELGNLVSIVKQHIRNYLNDIFELIDNYWTPISNIQITIIALIEAIAKALDGEFKVYLPRLLPHMLLIFDNDTTERRKATLEVLHAFITFGPNIEEYLHLVIPAVVRFFEKPDAPPLLRKQSILTITALCKKVNMADYASRIIHPLTRVIPILPHDTRNAAMELLCALIFQMRTDFAKFIPIINKVLTRYKVSHHNYELLVNKLLKGENLPQELGKAMDNREIKNEDLISADTSAAKKQPVNQQHLKKAWEASQRSTKEDWIEWMRRLSVELLKESPSNALRACYHLASVYTPLARELFNAAFVSCWGELYDQYQDELVKSLEVALKSSNIPPEIVQVLLNLAEFMEHDNKALPIDIRTLGYYAQRCHAYAKALHYKETEFHQEQSFDAIKSLMTINNVLQQPDAALGILTFAQASLRNENMVSWYEKLHRYQDALEAYEQQQLKRPGDMDITLGRMRCLHALGEWDRLAALAQEKWVHSPLENRKRMATFAAAAAWGLGQWDQMDEYIALLTPESPDRAFFRSVLAVHRNRFSDAEKFINRTRDLLDTEMTALLGESYNRAYTTIVRVQMLAELEEMITYKQSSNDPEKQLSIRKTWMKRLDGCQRNVEVWQRILRVRGMIVSPQDDMDVWIKFANLCRKSGRLSLSDKTLKSLMVIDRDNNGINGGPHPKVVYAHLKHMWASASQANNDDQANQIRSHTLTVLRDFTVQKTQDLGLNPDEMAVSLPIDPSRISEDVAEYTNLLARCYLKQGEWQRALTEDLVEDTFPDILRSLLLATRFDQNWYKAWHTYALANFEVIGHYESIHGENMPNNVVEQHIVPAVQGFFWSISLSKESSLQDTLRLLTLWFKYAYHSDVSTAINDGFETISIDVWLQVIPQLIARTHAPNPNVRRLIHQLLIEIGKEHPQALVYSLTVASKSQSVSRKRATFAIMDRMRIHSPKLVDQALLVSQELIRVAILWHEMWHEGLEEASRLYFGDHNIEAMFACLEPLHNMLDRGPETVREESFHQAFGRDLKEAQEWCRRYQETQDVNNLNQAWELYYQVFRRIIKQLPQLTNLELQYISPKLLEVHDLELCMPGQYKAGEPIVRISRFHTNLSVIASKQRPRKLTIAGSDGKDYSYLLKGHEDLRQDERVMQLFGLVNTLLVNDPETLKRHLNIQRMSAVPLSPNSGLIGWLPNTDTLHSLIRDYRESRKILLNIEHRLMLQMAPDYDNLTLLQKVEVFQFAYDKTSGQDLYRVLWLKSRNSEAWLDRRTNFTRSLAVMSMVGYILGLGDRHPSNLMLDRISGKVVHIDFGDCFEVAMHREKFPEKIPFRLTRMLVKAMEVSGVEGTYRISCQQVMRVLRDNKESLMAVLEAFVYDPLVNWRLLHTANPSPRPVVGIAVDRNRSVDQMNAEDIESDPRNFSVSRRQSRQELDAAASEEAAGAPEVLNTRAVDVIHRVSNKLSGRDFLPTQTLDVPTQVDKLIQQATSIENLCQCFIGWYVTVVFMCAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIJ2</accession>
    <name>A0A8H7PIJ2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">biotin synthase</fullName>
            <ecNumber evidence="4">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_004235</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIJ2"/>
    <dbReference type="OrthoDB" id="2414104at2759"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000011">
        <property type="entry name" value="Biotin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="BIOTIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976:SF2">
        <property type="entry name" value="BIOTIN SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01060">
        <property type="entry name" value="BATS_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00272">
        <property type="entry name" value="biotin_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01278">
        <property type="entry name" value="biotin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="86"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="365"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2174214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="393" mass="43128" checksum="72D19234D233678C" modified="2022-01-19" version="1">MSAFRLALKPLKLSQRLYGTATPARMASVTEAKAVAPKAVSAAALHASGPLRNDWKREDIQAIFDSPLMDLMFYGAKVHRENFNPLEVQQCTLLSIKTGGCSEDCKYCPQSSHHKTLVKAQKMLDTGEVMDAARKAKAAGSTRFCMGAAWRDLAGRKSNFNKILNYVTEIRGMGMEVCCTLGMLNEDQAKRLKEAGLTAYNHNLDTSREFYPKIITTRSYDERLETISHAQGAGISVCSGGIIGLGETKEDRVGMLHTLSTLTQHPESVPINALLAVEGTPLEKQEPVSIFEMIRMIATARIVMPKSMVRLSAGRVRFSQSEQAMCFLAGANSIFTGDKLLTTPNNEFTDDQQMFELLGIVPKPPNFEQGSDKPEQPSYNNGIKIKAELPSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIX6</accession>
    <name>A0A8H7PIX6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphatidyl-N-methylethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="17">2.1.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Phospholipid methyltransferase</fullName>
            <shortName evidence="17">PLMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">INT43_005761</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32739"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 17">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Endoplasmic reticulum membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Mitochondrion membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.71" evidence="17"/>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIX6"/>
    <dbReference type="OrthoDB" id="8300106at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000773">
        <property type="term" value="F:phosphatidyl-N-methylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000005">
        <property type="entry name" value="Phosphatidylethanolamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03216">
        <property type="entry name" value="PLMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024960">
        <property type="entry name" value="PEMT/MFAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458:SF5">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005444">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51599">
        <property type="entry name" value="SAM_PEMT_PEM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 17" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13 17" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14 17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Lumenal" evidence="17">
        <location>
            <begin position="1"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="intramembrane region" description="Helical" evidence="17">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="17">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="17">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="17">
        <location>
            <begin position="113"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="17">
        <location>
            <begin position="177"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="96"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="178"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG2174703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="210" mass="23512" checksum="83B18315B5076D62" modified="2022-01-19" version="1">MDSFIDFSKPSLYWSLASVLFNPIFWNTVARAEYRNQLLTRLAGGKPYLGCYGLAVTIFSLGIIRDFIYKAALEEQPVHPLLQTEIAKYAAILLFSTGNILVLSSMWALGVTGTYLGDYFGILMSERVTSFPFNVCENPMYDGSTLTFLATALWYGRPAGVALTVIVYVAYQVALQFEGPFTTMIYENKDKDVKRRAAARTTRSSSKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJ09</accession>
    <name>A0A8H7PJ09_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAM192A/Fyv6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_005920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJ09"/>
    <dbReference type="OrthoDB" id="75720at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039845">
        <property type="entry name" value="FAM192A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019331">
        <property type="entry name" value="FAM192A/Fyv6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495">
        <property type="entry name" value="NEFA-INTERACTING NUCLEAR PROTEIN NIP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
        <property type="entry name" value="FAM192A_Fyv6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="4">
        <location>
            <begin position="9"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2174858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="234" mass="26521" checksum="EBC9DE2C9B33D7B4" modified="2022-01-19" version="1">MSFNISSSFVSREVIDEDGNSKQLEWDKVRSDAEKADAAPSVPTEPYDPRTLYERLQEQKTMKEDALKEAMRFSNLVKRIDDDEMDYYRTLTDTQIQAELAKKRQEAEQLDEYRRAVDQASSAPEPPSLTSTRKNESKEDIKKFNKLPAKRSKSTKDLLQGVVVAKKRNADENGHDAEDKPAKRPDVRGKQEKEGVTKNENTSQLKQDNSLAAKSNRPISSLVSYGDDSSSDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJA1</accession>
    <name>A0A8H7PJA1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_005857</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070013">
        <property type="term" value="C:intracellular organelle lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000004">
        <property type="entry name" value="Heat shock protein 75 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000004">
        <property type="entry name" value="Heat shock protein 75 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000004">
        <property type="entry name" value="Heat shock protein 75 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006607">
        <property type="entry name" value="DM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21071">
        <property type="entry name" value="LARP1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00684">
        <property type="entry name" value="DM15"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="11">
        <location>
            <begin position="1042"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="787"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="838"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1138"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1340"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1387"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1624"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="787"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="815"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="842"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="895"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="919"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="958"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="976"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1146"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1173"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1198"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1345"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1387"/>
            <end position="1401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2174795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1652" mass="185174" checksum="DBC2F4EBE87A04A5" modified="2022-01-19" version="1">MLRIVARSSARLATASVKQAVAENFTVGSIKNASTLVRKSMLEASTIPVGSKFGWQKLSYSTDTTADKPDQLIEENEVVTGQEEVHEFKTETKRLLSIVANSLYSEKEIFVRELVSNAADALEKLRHNQMLQQGLETGKPLEIHISVDQAKKQFIIQDYGIGMTEEEINQNLGTIARSGSKAFLEKLEKDGSGGSKDNIIGQFGVGFYSTFMVGEKIKVYTRSAQPGSKGYCWTTDGQGSYSLAEADNVTVGTKIVIELRDDCKQFASKIEVDSIIKKYSNNSLNPLSPISFVGFPIYLNGGKVNTVEPLWTKEKNSVTADQHKEFYRFIANAWDDPQYTLHFKTDAPIAISSILYVPERHMEIIGQRQEPGVSLYSRKVLIQPKSKGLLPDWLRFVKGVVDSEDIPLNVSRELLQDNILSRLRNVMTSRVIKWLESESKRDAQRYNDFFLDFGQFIKEGVCTDAMHKKDIAKLLRFETSATKDNEMISLKEYTDRKKEEQKRIYYLLTPKRKFAEESPYFEAFKKNGIEVLYLYDTVDEFVVNHLREFQGLDLVAADSPEAADDSLLRQHTENNESSGSNLSEAEAKELAKYIQETLGSNVVKQVDVSRRLVNYPAVVLEHESPAMRRMMQMMQGSAKMEEAEAQPTRLEINPDHAVLKGLFKVRAEKPELAKMVTEQIYDNALCAAGVLDDPRSMITRLNKLLEFSVENVVHQDKKNDSILEVKCTNEIKGRQFVTPNKIHSTTATFRYLEADNHWPRLALGAEKFPGLVTAFNEKFKAKQTVAMSSSTEVTPEKQNQNVEKVEVDTASTDAVKAEDNATEKQKILAPIPSVNVWQVRKSSTSPSSEEPAPIAAEKSEQPAQEETTSKKSKKSKKSADLPSLQDSTSWPAPNEAKELPVEASEKKEKRPPRGKGQWTTITPTITHTTPTPGSRSARPNRRRSDSENKKKSHRGQKDNASVESKSGSAVEKSTPAQAEKAQSSAAKSIEASNTSLENGHGQRGAYRGRGAARGRGRGRGGFSQPAAGAPYMNGRPKSGYVNVDAETLKAFLLQQLEYYFSIDNLCKDIFLRKQMNDQGYVQTSLIANFNRVKNLTTDMDLINEALAQSDILEVDGDMVRKREGWDFWLLNDKAQDHENHASENTAAPASSAAPAQPAAAPEAQRKSSIAEVASKAAAKPAPSLASLAGHPNAKAPQPQLNGNHNGRTNNAPGTKAAEPAKEDDELFEFEEDWGDDAREGTVKKYYLSDEESDDDDDAIDIDDDMVARIMIVTQRKRDKSHVSFERAKMNDEISDMINEGLYHYEDDLQKNKTQQGAASHASNQKVETVNSDHFAELSASAKASHGSQLTGNNMSSTKITQKPISTGKKAPRFYPVRAESLPQSALYGTSAGSLPRNNAVTGNKKDSRQYSSQSAVGWVLSDQPYHYNPNDLLSTSYTGTSPMYSNLSEQLSTSVDMAQSFPNFQHPSHDLLRENGFMQHKYHKYHAKALKERKKSGVGQSQEMNTLFRFWSHFLRDHFNKRMYGEFKRLAIEDANQNYRYGLECLFRFFSYGLEKKYRLEIFEDFMELTLKDYDNGYLYGLEKFWAYLYYRKDKNKRKLPSNDRLNSILAKYKTLDDFKKAEPSKVHTETYTVPHHGKPRGSVSGPSASGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJB9</accession>
    <name>A0A8H7PJB9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJB9"/>
    <dbReference type="OrthoDB" id="2392825at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2174928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="360" mass="40581" checksum="190910235D0F8145" modified="2022-01-19" version="1">MRSSIDLLTDQLESTGQQVTYLRTRLSRIESSSMLLIDQIKQVVDVPESTINTDDPTGWQEDKYRKIRKHLQQLISQAERTLISNGLEDTEEVLVDDDQAVINHKIKINQNESESISQQFTELMKAVDENGEYVCARCHAKPKMEGNKNHLQLVAAKLGIPEDFIITLLRMVPYLARHAFSAFTLLTAILPALRSILGRRKAKLLPKMKVVSVNRTKTAILSEVIYFAILAVTYTSEMFGEDGAFSAIILRGKELWQAIINRDTTDIDADSDDTEKRRQRMLCSFGNLVNKLYAFIETNERNEKNVKKVVSNTVKVENFVGKLTKASRARSSPLMSLATLIIYAAGIVGAWQVSKRSTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJL6</accession>
    <name>A0A8H7PJL6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BAG family molecular chaperone regulator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_006002</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJL6"/>
    <dbReference type="OrthoDB" id="417450at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039773">
        <property type="entry name" value="BAG_chaperone_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12329:SF16">
        <property type="entry name" value="BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12329">
        <property type="entry name" value="BCL2-ASSOCIATED ATHANOGENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00264">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="86"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="BAG" evidence="4">
        <location>
            <begin position="194"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2174940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="29869" checksum="48FB12423DE339E3" modified="2022-01-19" version="1" fragment="single">HTCWSNLHSEIDGRQTGHLPSRFIKIIAQQLAIVYLLLWRAFISTLSSFIGFKRVKKHERKSTLLLKWENHSYDITFKEFSKGLDEATLRDLKEKCKLATGVPVAAMKLTVSGANMKDETAQLSSYGVHSGSIIVLEGKPPGEDEIQETASGNPEEVGLNLRIAQTVEKLKVASVPVIEKYDTEVSEYIAAGTIDEAKRRKLYDMSAFINEQIMQALFTLDGITCASEFTTARQKRREGVRYAQSLLDRLDKIKADLKAHIELLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJS6</accession>
    <name>A0A8H7PJS6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH dehydrogenase (Ubiquinone) complex I, assembly factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_006067</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NDUFAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2175005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJS6"/>
    <dbReference type="OrthoDB" id="270318at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181:SF13">
        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE) COMPLEX I, ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2175005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="35838" checksum="241A35A6F4D07CD4" modified="2022-01-19" version="1">MRLYTSLLPAGRAINTTFRKPLSNVRFASSNTPSIETAQKYCADSVRKHDYENYLCIPFYPRELQNTQYAIRAFNVELASIRENVSNPMIGKMRTQFWRDTIDKTFAKAPPQQPIALALGDALQRTSLSPMWFKRIINEREENLEDPQFMTIKDMEKYAENTASCLLYLQLESLKIRDVTADHIVSHIGKAIGIATLLRALPFHASQKRLILPAEVTAKHNVVQEEVFRQGHSEGLEDAIFEVATAAHDHLLTARSMLKSVPPSAMPVLISAVPTAKYLEKLEQHNFNAFEPKLQLKSWKLPLDIWSAYRKQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PK44</accession>
    <name>A0A8H7PK44_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PK44"/>
    <dbReference type="OrthoDB" id="5516192at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="90" mass="10294" checksum="49C1877273C005F4" modified="2022-01-19" version="1">MSSSDDNQKDSHIVFNRHSNTPSAKPKSHRCNEHLEDVLNGISSWPMDFSKPFGVFWKCLRSQPGQEPTLYRNRNSEAAIIESEFVGDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKD9</accession>
    <name>A0A8H7PKD9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_001299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKD9"/>
    <dbReference type="OrthoDB" id="434253at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243">
        <property type="entry name" value="AGL049CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE ALR4036 FAMILY FMN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2175652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="250" mass="28485" checksum="1B472C07DDE911AF" modified="2022-01-19" version="1">MNGIKRQSSSSDTVVNNPLASSGMSAWYEALKKSYTRNYVYSEEPVFVHMSNIKRSGDVSMHSLHFQDFLEDDCRFLEFLLAMNDNLLMGDIKSDPNARLCWSMPKTKEHFYLHGKFYIASAPIQVTRFPAPKVVNNDIVAADYWEAERLKQWQKLDAPTRAMFTWPPRRETPKAAKIAFSCTSLEDMTSNSTARKPGSVQVAHDIAMDNFCLLIFKISAVEHFQYNNFPPQRNMYTIQGGDCTASEANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLC9</accession>
    <name>A0A8H7PLC9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_005395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLC9"/>
    <dbReference type="OrthoDB" id="308449at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051959">
        <property type="entry name" value="PAK1-Kinase_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675:SF1">
        <property type="entry name" value="P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675">
        <property type="entry name" value="PAK1 INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="154"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2176162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="41235" checksum="3DA30D02E7522935" modified="2022-01-19" version="1">MGSKKRSRVPNVPVEQPKNSIDWDEQTSKKKAKKEVDSDDESAGKTILPVEVLTEQITNEDFRIVAGSYERILYGINAFWEADDDEKVLQQTAVNASSSKLYDLKKRKELGALAGQQQGDINAIEFYGKYMLSASDDATICIWRSKDWELLKTMKGHQGRINSLSIHPSGKIALSVSADKTVRLWNLMTAHKASVHKIGKEGLVVRWNPDGTQYAILFERQVIIYNVADAEPSVTIDSRTKLLCMQYYKDKAADKEYLIVGSEDRCIRIWDAQTGDKVAEISQHKMRIKGIEIITSTPRLDSFKKPIDVLVSVSSDGVMKCWDLQRAIETKGEDIKALGEYDAKCRVTCCAVTLGYKVSKPSEDDATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLE7</accession>
    <name>A0A8H7PLE7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mediator complex subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_001256</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20828at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019035">
        <property type="entry name" value="Mediator_Med12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021990">
        <property type="entry name" value="Mediator_Med12_LCEWAV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09497">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12145">
        <property type="entry name" value="Med12-LCEWAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01281">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12" evidence="11">
        <location>
            <begin position="129"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2175609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1883" mass="215037" checksum="9B36B9A15F08376E" modified="2022-01-19" version="1">MASPYSSSSSPGYYSPNVPKYQQAHNQPLKKYILQPPPRRPLLSKALPSLGYPDMFPQKPGQDEDLLNETTMRNGFFDKNVISNEHTCAHDMVYGKLQDEQRLLNDLGSFMVDVLKRRREAGKLAGPASFKAPNRATLNDQKKDQWMSDLSEGSIPLRKLARNVPHGFKGEKLLDTLAAKQVPFMRATWYIKIVGMNEIRTNITNSSHSAQQHTLQWTIVVANHLKKQLSEISPHVSSAAISYGTPANYPTPRAYKYQGNSQTENSPSVNIAKPWTTPELRQRFEQKWHYSTKLARWQYCEGLLDQRTFLKWSLDSLANSSSFEVMWLTLSAVVKDYLDEYKQNRLLMRILIETLVKATKALTEHPSYVENGNWIYGYLYTDIKRVLQSLFLSTPDMFVIPKLYHQYSQLLYTTLVTNPQTPHQTTPEAIALMRYYWKEISARNETFCGSVREVKSETTEEVPNTLNHLFNLAETKNDVDEEEQLILFLDDVGLTIDSGVGLQIDGANNNEWKDIRGWTASSVCAKIFGSSKRQDDTQALYKKVETLCTWATTTARHGDWRAYLVSSVLCQFIEGITEEPSQVDEAEEIHNNDHTEQTRRNIVQESLMSFLDQNDITDKESLSEDETDMDIDHVEPMSVRSSLGYFFDILIRQGIFSYHKYLLRLIARGDLEPDKRNCEKSKRSLAYLRYLSLAEKMPSYLQNQRRVAIYEAANKNGDLEEDRMLSALKHVAQAALLGKGDPSKGPFGFNVDIMTQPESDDTIQDFQLYLTDHLEQAVQRVVQKSSRYCVVKFSRDWLVSEVKKYVVRNVQIGEDNWRVMTSPGSCLMNARQYLTVIRLFEIVQDYTNAIEISLWTLENTNESTLYPCIIDTLHRHSSVWKLANMTNRIASAMWTKHLLLASRGIPERCIMIFIAQLIQAGVAISDDDRKKLQSDMQIKIMSPEMSLRRQGSKTSMQQELLRLISNPSDVQQIAISLYSRHPGDPNFISTLLNAIFQTLQQLAKEKGVVEAIDSRDIGEEAEVAFAHITNNEGNLASLPTRYLEFRNYIQIFADLMMEITNLCKINGQLDNEIIELLNQGCDLFTDHPATQLIKDAVTGPPRHHGFGNWLFMFVSALVARKVLRLDVLLVRFINPTLDLIAKRLVQLQQDQHEAISNTNKEQLLMQLCNNISIMVRSLIVQDTNIVKYQSAGRRRQSTSDMDEQLSSGTHTWKESQTWVMRLDELFSLQTLRKIYLASTMQGLMEVFHLLHGFAQVASQLALSSPLLHDLTILRSDILSLSWFKCAFLRDMGIIYDHIAEEPTYGATSDENGMPDTANDQTYRSRILSILNELICATSSQNFNQGGPSNVNTATSNIIDKFKDILSNINQWNFERSRVQLCLLLDAKVKPKFSRSDSSGDVNMNMTSSLANAVDQGFDSNRQDNEWSDEDLKAFVRFFFDQAILMNEQDLEQRASGGLQDDQNSNIHQEAALRKTRFLKNLVQSIRNELVEALLNHGVEILAGPTMATEAMSSNFLESILLCSICDSQAPDFASKRHDCRAKSFFEIMQVLIAENVWDNSQKIDFLRTSLTQIKRFTEPSNIYNIMHSCDVSYVDAARALQISSNNTDAAIAALKTDSVLQQESEDVGWERAVKLKDIRISLLVRLRLIIPFVPLIWENPEKCELLQWIVTLVEILETPLIHGNGSQESFFEFVLDLVSLLMDEVPKELRKNNLVQLSTLQQNLKLPPIFASRIKRILPFQTHNAYLTNIKLPAALQTPSTFDHPLNNQQQLQLYLQQPRPWEWIEDYVPEPIQDNDAAINLAWFNARKLKRGEATYSRWFKLGFGSNWIDNDRRVVGNENEEEQEQQFDPMVLDAAGATDVHAGVKRKLDVEEGEIADDNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMB6</accession>
    <name>A0A8H7PMB6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_005713</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMB6"/>
    <dbReference type="OrthoDB" id="417208at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03359">
        <property type="entry name" value="LbH_Dynactin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2176473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="188" mass="20734" checksum="5F1F77B6E32BC3CA" modified="2022-01-19" version="1">MELPVTYYDRAEYIETDTGNKVSRKSVICGSQNIILGGKTIIQTGCVIRGDLRRTGGGHTVVVAIGRFCLLSQGSIIRPPYKTYKGIFSYYPMKIGDHVTIGEGSIVQAATIGSYVTIGKNCVIGRFAIIKDCCCIEDNTIIPPNTVVPSFSIYDGSPGSYKDELPECTQELYEQKTKDYYSKFTPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMM1</accession>
    <name>A0A8H7PMM1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar protein-sorting-associated protein 36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ESCRT-II complex subunit VPS36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_007653</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the VPS36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMM1"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000165">
        <property type="entry name" value="Vacuolar protein sorting protein (Vps36)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021648">
        <property type="entry name" value="GLUE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037855">
        <property type="entry name" value="Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128:SF12">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11605">
        <property type="entry name" value="Vps36_ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51495">
        <property type="entry name" value="GLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GLUE N-terminal" evidence="13">
        <location>
            <begin position="7"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="12">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2176999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="516" mass="56157" checksum="B2F9A91C71DD295F" modified="2022-01-19" version="1">MNRCKPVDLSSSQRPVLLPGERLLASQGQVGLYDGFVLCALTSIHKDKSSLHQEGVCYITSHRLIYVDTKVPRVNSVQLDLDTIKSIDAYAGFLSRSPKITIYFSNARAPSPSTPDTVVSKQVATWLCPICSFQNTDDIEKCQLCGVFRPANIQITTSSSGESVVSASASASAPAPTENTCPVCTFINHPSMQRCEMCDTELHPKSATSVTAPSLEPESSSPSTSSPTPEVMDEDSPFIKVAFRGGGGGYSTCLASLKTAIGNRVWEQVQKPVQEPDRQVTSSRGAGISAIQERIERTQLDAAESLTDAFKDLDGLMAKAAEMVRLAEAITTKINKEPQGSSETDTITLNTYLMELGIPNPVTKDSTGSSYHQELARELSDFLVPVLDRQGGMKSLADVYCLFNRARGVALISPEDLYKASCQFSTLNMPICLKRYESGLLVIQSINLSDDRVAQRIFNHVKKYGPLTAMKISELENLALPVAVEQLHMTEAKGFLCRDASSAGITFYENLFLQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMP6</accession>
    <name>A0A8H7PMP6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcriptional coactivator p15 (PC4) C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_005745</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transcriptional coactivator PC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMP6"/>
    <dbReference type="OrthoDB" id="2505440at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045125">
        <property type="entry name" value="Sub1/Tcp4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13215">
        <property type="entry name" value="RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="ssDNA-binding transcriptional regulator domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional coactivator p15 (PC4) C-terminal" evidence="8">
        <location>
            <begin position="102"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="36"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2176505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="163" mass="18540" checksum="8BD2FD53492EE26B" modified="2022-01-19" version="1">MGKVAWLRAKNSPATAQSAFNFVTYRRVSSRISPSFISDMADSSESDTAYDPKNDSASEEEDVEDVKVAEKEVKKSNKKRKLTDETPESEKTLKDEKGNTYWELSGKRRITITKFSSGEKAIDIREWYKKDGESRPGKGICLPKSQWEKIVDLLPELNEALRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PN26</accession>
    <name>A0A8H7PN26_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Rad50/SbcC-type AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_007672</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PN26"/>
    <dbReference type="OrthoDB" id="10072614at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="14">
        <location>
            <begin position="14"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="602"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="198"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="364"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="620"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2177018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="636" mass="73389" checksum="FA4BEA159E75D138" modified="2022-01-19" version="1" fragment="single">MPDISDTGTIGAMELVNFMCHKYLKMDFGSKINFVIGHNGSGKSAILTGLTVALGAKAMVTNRASNLGDLVKAGANVGQVTVKIINKGIDAYKPDVYGEFIMVERRISKNGSSGYKIKTAAGKTISTKREELIAICDHMSIQVDNPLTFLSQDSARQFLSSSTPEDKYKFFLKGTQLTQLTQDYEQIRESVDSTMVVINKNKNGLEDLYKKAKEAELRYREILEAQELDEQIDQLSNELVWLQIITKEKQVRRAQLDESKANETLQATIARHQRQQEESSHLQQETQNIQRELAELRRQTEPHAVEKRKLLDMIKQKDKDIQAIMDQGREINNQVKSLRSQIGAYDKQIKEEASKLESENRSRREHTTQNIERLQAQLDETRNEFAAMEKKILSITNQEEEDKRRKEEMELDLRRTEREHGDLEKSIRDMKSQKENRLRAFGYNMPDLVEDIAREKRWRGRAPVGPFGRYIKLERPEFANVLETTVGRMLNNFVVETFEDKRLLSQLLDRRKLNNCQIFVAKYDLFDYSSGEPDPKFFTILKALKFENEWVKRQMIIFGSIEKIILMSDRAEADRVMYNNGQPLKNVKSCFTSQGHRVGANSGMRTESLPMYRGTPRLSTDIDEKLREHQQRLDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PN95</accession>
    <name>A0A8H7PN95_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007879</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PN95"/>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051767">
        <property type="entry name" value="Nucleoporin_NUP42"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46527:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46527">
        <property type="entry name" value="NUCLEOPORIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="330"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2177222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="378" mass="38129" checksum="8D8744E601497EEA" modified="2022-01-19" version="1" fragment="single">VMKDSCTPILIYIDSETSIKTDLTTEKPIWDLSIYGPAKEEPNMIVGTDLSPEEDRVKYYQSRLQTGNETQYLQEREQLVQKMNQQVTSITNDTTGAINHFNNQKRQTSTGFGGSSTPAPFEPFIKQTTGFGSGGSFGNNAFGSRGSAFGMGSTNTQQTSAFGGGNAFGGGAAISTPAFGSTGFQKSTSAFGNLSQPAAGGFGSNTASAFGAAPSSTPAFGTTTSPSAFGATTSPSAFGGASSTSAFGAPSSTPAFGSTSTMGGMGGSPAFGSTSAFGAAAQPNTGMSMPGTSSFGAPSVLGSSAFGASTQSFGASQGLGSFSSLAAGANPGFGAPAAAQPQTMNANPSAPSSNQDAFNAPLFQYRMIPEQEPPIELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNI8</accession>
    <name>A0A8H7PNI8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNI8"/>
    <dbReference type="OrthoDB" id="2411579at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="517" mass="57647" checksum="E0EA1559D5A927B6" modified="2022-01-19" version="1">MEPPKGSEATNGSFDDYMTRLSKQSQELSDQIQTILKHQNHRASEDESYSTATPSPPPPQVAYRHYRQRVSSPDSETFGEWRRPQQTYHRSRSVPSLRQAPRYYGPEDSGSSVTEATQSGSDDDAESDISGSQSPQEYTNNQQMVQRRNSWDPMQPAPFDARMQLYDRHPHTRTHSGPMSAVPVGPMSAGPILQRRPTLGYGQPEPFPQPEPFPQPEPFFADPMSPDIPMMAMQPPMMFIPPPPPPPPPPAMGCPPEFMGMPTADSGIMSTGMMNDPPMLEILEGPMPSDRMDGSMHPPPGPPGHDPSAGNTQYQRSPPELYPPAEPMSKNQSRRQRMIGVIKQKLGRAYENRSIRYSMMSQRLYEQGQGAQAAAEAATSTQQQSPPSQQPPSRRGSLRRSRSLRQQASNGAGFDKSEPMMWCFRPQRKLASLPWEPFDRASQMQLTEAANAGEQCTLQDSHFAQPINVVPSSGYGITTKNYGHHAVYSVALLDPTQQVRTIFFCIPIGRRRVDTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNN7</accession>
    <name>A0A8H7PNN7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNN7"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00177">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF14">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="1">
        <location>
            <begin position="29"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="298" mass="32535" checksum="4123AF475B1C69BF" modified="2022-01-19" version="1">MTIIESDNRHAETTRKALTYFKELADSLDGWDFASETSGVKLYKKTVEGQALPIVRGDIILSGKDYTLSQVAAVATQPGCRKIWDEKFDVAEVKEAFTFRETLFWSKLKTPWPMSPRDLSGTAIRDVADDAVYVSMTSVEDADIPEIYGNVRATLYVSGWKLSPVPEGVAVTYVTQIDIAGSIPSSFLASIQQQIPLCAGKVVDYVETHGYPPYLLDCTAVYEEEQFNHDAKEYTLILKGGQADAVATLDISSRLYPNGINVDIEGGAAHKIEDGENGAKVLTIHNIEGAATVKVTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPQ0</accession>
    <name>A0A8H7PPQ0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">25S rRNA (uridine-N(3))-methyltransferase BMT5-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPQ0"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="60"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="306" mass="34919" checksum="C0BE8BBBF467E04C" modified="2022-01-19" version="1">MPPKKLKSALNNLLSAQKEKQKKSEKQKRAQQWEQERRKKQSQQQTQKQKTPYEFNDKILLVGEGNFSFARSLVESVVHGGDNITATCFDSEEVLAQKYEDESKDNIQVIEELGGTVLFEVDATQLEKCKAIKQRKFSKIVFNFPHAGAGIKDQDRNIQSNQVLLKDFFKSAAKLLQSRVEGDENDGEIHVTLKSGQPYDLWSIRTMAKSTDLLRPKTAFPFVPSLYPGYAHRRTLGFKEGLSKSGNEEIIDKKPKTYVFVRSQVMQDEIDKSKEGMAKKRSVMRDMQGPNKKKARTSSHPESDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQJ3</accession>
    <name>A0A8H7PQJ3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">R3H domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_003328</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQJ3"/>
    <dbReference type="OrthoDB" id="278430at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02642">
        <property type="entry name" value="R3H_encore_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051937">
        <property type="entry name" value="R3H_domain_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672:SF8">
        <property type="entry name" value="PROTEIN ENCORE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="77"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ" evidence="4">
        <location>
            <begin position="141"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2178075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="56875" checksum="82651ADEF91269CA" modified="2022-01-19" version="1">MSRSSSPSDEVPVDKFANLNIDASKVQQPTGEENKNDVSESSNSENDTNDDKQDVEEMANPALDAVILAALRKPQDRMFLLKLDLEFENFINNPARVRLDFPQMNSYQRLIVHRVATYFKLTHLFDPVRRSIYLCKNVSTEVPSVRFADLVEKEEEPVSTPKFQIMQRATSDRGHRKGDVSPGDGNLSSDGKNALNRKQMTLEERQVAYEEARARIFQDFGPNSAEGSEVEGDNSQASSNISSPAIKDAGKKISGRSSPVDNGDDAGTVRTTPNRGKPFTARTQSNSKRPSPRDKESNADGSPNPQNRLDPLNRFPPQPYIAQQPLHPAYQQQQQQQQSLAYNSRPFGYAPPYTSPVYDPYNGPQWAPGTDVNANPNFSNYWKQPRPQSAANSTVSPHLTSPSSSSLPPSQPLSRVWSSNTNASNDSWSPSSQEFPAIYNGQPQNLGMRPQRPNISPGTGGHFYNTNANYSNPNVPFQDRRSPINGQMNNGNGQPAGVWSNRPDNRDWGPLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQM4</accession>
    <name>A0A8H7PQM4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_003001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQM4"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000004">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1660:FF:000002">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1660:FF:000004">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001859">
        <property type="entry name" value="PRK00591.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="7">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2177754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="372" mass="41791" checksum="2A27DFA9121D564A" modified="2022-01-19" version="1" fragment="single">LAESSLVTPQLESKLKTLSERHDSLLSKLNNSQSLDNATIASVSKEASDLAQLSTLYSEWTRTNTDLEDLFNLLSTSSNDQDMLDMAREEHEELTNTLQKLEKDIVSELVPKDTADEGSAILEIRAGAGGDEAALFAGEMVKMYERFAQERRWKWELLASSELEGGSKGYKDVTVNIAGKNVFGQLKYESGVHRVQRVPATESQGRIHTSTITVAILPQPTEVEVQLKDSDLRIDVYRSSGAGGQHVNTTDSAVRITHIPSGMVVAMQDERSQHKNKLKALKVLRAKIYEQERLKTDHARRDSRNKQIGSGDRSEKIRTYNYPQNRVTDHRINLTLYELDLIMTGQNLPNIIDRLKLHYDTEALLAISDIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRC0</accession>
    <name>A0A8H7PRC0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_001888</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRC0"/>
    <dbReference type="OrthoDB" id="416729at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014612">
        <property type="entry name" value="Pop7/Rpp20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15314">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15314:SF1">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12328">
        <property type="entry name" value="Rpp20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2179039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="163" mass="18162" checksum="84C33AC3E7FE7691" modified="2022-01-19" version="1">MVHDQAPAAKRIKVEGEIQKRTPQQPATIPTDIYVSNKSAFSAQLARAKKLLLLQEYRSITIHGLGASIEKALQLSLKIQSELQYQVDLKCTTGTIELIDDIVPEDTEQDLQTQTRNNSAVHIIITAKSTITDIRARSRNAPRYKKHHGTGDRQGRGPQTTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRW1</accession>
    <name>A0A8H7PRW1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_001793</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRW1"/>
    <dbReference type="OrthoDB" id="6093671at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023270">
        <property type="entry name" value="RCMT_NCL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="58"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="462"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="176"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2178946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="740" mass="83561" checksum="886E6A16CAAFAF5E" modified="2022-01-19" version="1">MGYGKKRRSKRGNLRGGNADEKKHGERLDYPEIDKHNQAFCDYYKAQGILDDDEFEKFYEVLKTVLPTTFRITGSRDTALELRDQLQNRYVPSMKDIEVEGEAIEPPTPLEWYPDNFGWHFKVSRGVLRKSPAMSAFHKFVVAETEIGNLSRQEAVSMIPPLLLKVEPHQWVLDMCAAPGSKTAQIIEAVHANDKKNEIPTGLVVANDADYKRSHMLVHQCRRLGSPCFVATNHDAGRFPKVHLKDENGRVYGMQFDRVLCDVPCSGDGTFRKNQTIWRTWGVGSALGLHATQIQIFLRGAQLTKIGGRIVYSTCSFNPIENESVVAEVLRLSNGALELLDMSQELKGLKRKPGLKTWKVMTKDKEWVDSLEDITDEKKRSKYTQSMFPPSNVQDIPLERCLRIYPHEQDTGGFFVAVFEKTKPMTGIDNAFIAHQKGLNVDEKEILESEKKDEELLESIAPKVEETEEVPLTQAKESETAAEIEDKDVDLPSKRAVGESAPNKPSKKARSMDTLKEAPFELMSPDNEDIVEASEFYGLAPTLPKTQFLLRSMEGNSKNRSIYFVSEAVKSILSSKDSSRLRLVNTGVKIFVRQGSAMDGGCPLRISSDGLMLLTPHISEKRCIDVSTEELRTIVTKAFPKTEEFDQSHVEWLTALEPGCCIFRYDTTKLADASQRGLWLPLTLPVWKARVSFNLLLNKKEKKSLSLRLFDVEPEEIPAELRNRQMANIQSEEGTPNTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRZ4</accession>
    <name>A0A8H7PRZ4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_001968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRZ4"/>
    <dbReference type="OrthoDB" id="2317425at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2179118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="50788" checksum="4E1E2AC01FD16055" modified="2022-01-19" version="1">MTNILNLPDEILQIIIDYAAISVADDRCQFLGWQYPKHNYYDLKCVAQACRRLYIITAPSLWRDKDFVLPCEDDTIGKESAVGMATDVLGRKTTFHYPQCVGYYVQSLSRDLTSGNQNDMNNSALMSQLVPNLRSLRMDFSPAERNERYGLDLFVKSCPYLDEIYLENCRDTFDDFRSLLDYKRPLKRITLLCCTIKETTLTELMKLSAKTLQDLLFQRVLIEPPSPAEDRQRVFGRGRPMAIAQPIFNRILSFHSLTQLALSDSLSHSTVQTIVTESQNLEKLAIILGEMDTTLTNHCITLLASLHQLTILSVAFRNVDPYSGTYERLPCLASPSAWSYFAARLPHISLIHISATEIRLSAEFFVRLFTYHTRLPNVMLHHIRWAFEDANDDTIREWLGWKDIQEYFMTQEEAQRRGFTCFDMNDRVCFVKGFEEWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSN8</accession>
    <name>A0A8H7PSN8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSN8"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="2">
        <location>
            <begin position="146"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2179055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="200" mass="22530" checksum="FC7814A978155C26" modified="2022-01-19" version="1">MTVDPPNAKPYPNAYPNDTHEPDYPNAKPSRPSVGDSHTTEELLDFLNAQTVDRLEEHDKPKIIESSRSARLRFEIPKTPSRQSAPMVPDREREQQSPKRRWSSPALRNKRQASILEEGPPPIQVGSKVKVLGRPLQTLGTVKYMGDMHLFPGEWIGVLLDERVGTHNGTVDGNFYFEAPAHKGIFLKRSQLEPYCPPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PT22</accession>
    <name>A0A8H7PT22_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_001863</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PT22"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13279">
        <property type="entry name" value="PH_Cla4_Ste20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000139">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000705">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="3"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="14">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="461"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="162"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="345"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2179014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="730" mass="82118" checksum="41D08B28974CF2A4" modified="2022-01-19" version="1">MGDIKKEGYFSVKEDGLRAWMWSKRYGILRDQTLTLHRNEQSGQCIALIFLKDVKSVDRSETKTYSFDLVTKDKTYSIACKSDEELYSWMDEIYNRSPLGASGPTNFVHRVHVGFDPITGAFTGLPAQWNALLKGSKITAEDAAKNPQAVLEALEFYTEQSKRDNEYEIEPTNSPSSPSPRSPDIRKQPHDKRSPSPSFKATRAAPSPPSSRSDNSSRRPPPPRPMRSQESNDSGLEGRMGDMSIDPRGSHTRYHSPPSSRSETSSKDKADLQGLPSSKSRSPGSHSPGASSNSSSRPRPPLYPKDLARSGSSSSSYTQGAQVIQNAMARSNSQRGISPGPSSSSDRRERDRERELIERENERQMRRHKEREAEHRAREMERKQQKERQKERERERERERERERGREREREKESGRAPQHAPGDAPAKPVGRRQKAQQMNEAEIMEKLQKVVSPGDPNLLYKKSKRVGQGASGSVYLATQLSTSLRVAIKQMDLAHQARKDLIMNEIMIMKESHHANVVNFLDSFLLGGDLWVIMEYMEGGALTDVIDNNEMTEPQIASVCLETAKGLSHLHEHNIIHRDIKSDNILLNFYGQVKISDFGYCAKLTDQMNKRATMVGTPYWMAPEVVKQKEYGAKVDIWSLGIMAIEMIENEPPYLDEEPLKALYLIATNGTPVLKAPEVLSNELKGFLAVCLCVDVKSRASAAELVEHQFLKKACPPSSLSPLLKFRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PT40</accession>
    <name>A0A8H7PT40_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PT40"/>
    <dbReference type="OrthoDB" id="10378504at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="441" mass="48875" checksum="BDE9FE371ADEB9B7" modified="2022-01-19" version="1">MVSNASRQTKSKRQPLSSVHRNATPKTMQLKKPASRKLTQTLLKVAKESSLDIKTEVPKENRPVSPSFPSSFMNSHIPKKRVMPQSSQTLHDVADIHTTMVTRHLNRRQGSSRSNVKEKQEQTINLSTTITKVPFSKGISESALQNQKSDLRRQEQKDPKKNSSIPLKKRSLQNTKPIDDVQLTRTNTCSDFVDGAITLTTEQVDISPESASQEISTEDTETQVVKQFEKKCLDSSPTMKTGFKSADRRILKAEHTGQLHTKDTLCDKSPQALNDMTPHTPKLKVLKYTSPALQLGSEDKGKYMFTAVVDSESYTVRSTIDHSRTDSSPLSEIPTSSTDLLSPDVGYEIHNIYPNPLGYTLPEKLGLLNDTPGATIPLSLDASDFDVVPAFPNPTGKRLLEKLALAAQENQSSNMAKNYSTRHDETVDSASTDDIPSSPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PT73</accession>
    <name>A0A8H7PT73_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-deoxy-D-gluconate 3-dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003638</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PT73"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF5">
        <property type="entry name" value="2-DEHYDRO-3-DEOXY-D-GLUCONATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2179852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="27113" checksum="B4B48C3CF2F11444" modified="2022-01-19" version="1">MSSSHLALFSLQGKIAAVSGGTRGIGKAMAIALAEAGADIALLQRDLSNTEVRDEIRALGRKCEVLQLDIADPESCTKAIPAVLEAMGDLDILVNNAGIQKRHKAVDFPDEDFDLVMQCNLKSVWTLSQAAGRHMVKKGSGKIISTASLLSFQGGLTVPAYAAAKGGVANITKALSNEWASQGVNINAIAPGYIATDMNSALLQDDNRRRQIIERIPQGRFGNADDFKGAVVYLASNASNYVNGEVLVVDGGWMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTJ9</accession>
    <name>A0A8H7PTJ9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_002119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTJ9"/>
    <dbReference type="OrthoDB" id="2357632at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2179269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="384" mass="44802" checksum="8665EA0C863A382D" modified="2022-01-19" version="1">MNDTLQFQLLQQLLPLLLPLSSEEHQRALIDNNIMTPKQPRKMDYLLKQLRKHPTSSTVDAIVQECVHMTDQLRTNLDKLGHPSFTEQQLLEISDAWQIVGEEYDKKAQEQQEESQSMLDGLAALVRQWKAPQNIENIVATIISNQPGSLRLVQIDKHNYYRLGLSRHKLGQKYVILETRDREEQTQQVQQIGQDFSYIFAENAKNNLERLDQTYRYQGDINLREKMRVLLQHTTSHHQHHINNNYKLERIKFAATKMPNFAPAEWQWPDLVKVRHPYQPLLLGLYRNRSKQQKETQISTLSVRKLCEHFRKTGCEFYTSILDSAALLYSSDTKIMSQEGKQFLSMSVILQIEQTRSTLRKALVVLHQLRQAFAQQTAQPTSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUQ9</accession>
    <name>A0A8H7PUQ9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nuclear cap-binding protein subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUQ9"/>
    <dbReference type="OrthoDB" id="10252707at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027159">
        <property type="entry name" value="CBP80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015172">
        <property type="entry name" value="MIF4G-like_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015174">
        <property type="entry name" value="MIF4G-like_typ-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412">
        <property type="entry name" value="CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412:SF2">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09088">
        <property type="entry name" value="MIF4G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09090">
        <property type="entry name" value="MIF4G_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G-like type 1" evidence="2">
        <location>
            <begin position="62"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G-like type 2" evidence="3">
        <location>
            <begin position="277"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2179839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="67299" checksum="A84C4DFE3A27C85B" modified="2022-01-19" version="1">MLLKPYELFDEELNQALQLTLKLQHELPTFELPQTLTDATYIAPEQQFRIFYTEDPNPEKFPDSNSLAYFILQETMVDIINLFESNRKECSKYLLGLHNNFQPGTFASQSPSAQEQKADDQNNDMDEDPSGWKLSELVIEHVFGQLLRLPSPPVKHVYYAALILELCKVETSSLNQSLKKATHILFERLTEMDTGLVARLWTWFSHHLSNIGFDWSWDAWENALSLDSLHPQMCFMRETLEKEVRLSYYDRVKTTIPEKFHVIMASEPPAPSQELLNAEHPHSAIAKQILGMLRQKKDADELNGVLAELKQRELESGQTQEQADDTAREVFTQCVLLLGAKSFSHVLNVIERCLEVLRSLNQNPAERLHTVRIIARFWKSNTQLLGVLLDKFMNYRIIDPTSIISWIFENEQSEQVGRSYLWEILHVTLNKVINRAQHVQTKLNGFKDTHSKNEVARRDSISESVEAERQQELTAIQSVESSLETVTREQKEVFMVVLQKFVQSLQDMYSNFQARGLDPNTSWTYRWVNGWYKDVMRTYHKEISTFSVTLESLVFLDSLDKRILEPFVELKNLHQDQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PV77</accession>
    <name>A0A8H7PV77_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Replication protein A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_003897</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PV77"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000168">
        <property type="entry name" value="Replication protein A 32 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000184">
        <property type="entry name" value="replication protein A 32 kDa subunit A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014646">
        <property type="entry name" value="Rfa2/RPA32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036949">
        <property type="entry name" value="RPA32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication protein A C-terminal" evidence="9">
        <location>
            <begin position="169"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2180109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="272" mass="30291" checksum="A7547862DBCFFF08" modified="2022-01-19" version="1" fragment="single">YDNYGYDGMSGVENSGGGFLESSHFDNQGDNQLQSKPRASEQTLRPVTIKQMLNSQSAHGDSEFRIDNVDVTQVTFVGIVRKESEQQTNIAYTLEDGTGSIDVRQWLDQNHEELPEEKEKRAQMMSNYVRVVGRLTQFNNKTHVVAFQIRPITNANEISHHFLEAILTHLQFTKGSAPGGGSMDNFTSSAYNAGNFKSNNDQGSGGGIHKEVIAVINQFAHLDQGAEINQVVSRLQGKYSEPQVKEAIDFLQNEGHLYATIDEYHVKSADSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVA0</accession>
    <name>A0A8H7PVA0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVA0"/>
    <dbReference type="OrthoDB" id="10583449at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="165" mass="17874" checksum="7292257691E68334" modified="2022-01-19" version="1">MLSSPPQPNTGSDSNHAPSSTTDGYNNSSDNELYQQQHQHESFPEIYRSTLTDVPPHSFGCSDATDFSFMKHWPSGSLHGDADDDQSMTKHSSKLSESQDASATASSGPGSGDMLSDEDRERLGSIQRGENTAIVGWLKTIGNHKSHQGQANPKGTYPEMLDLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVD9</accession>
    <name>A0A8H7PVD9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008584</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVD9"/>
    <dbReference type="OrthoDB" id="275748at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12241">
        <property type="entry name" value="RRM_SF3B14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000604">
        <property type="entry name" value="Splicing factor 3B, subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034150">
        <property type="entry name" value="SF3B6_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="26"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2181002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="115" mass="13135" checksum="CAB8BA6BC3DE8A04" modified="2022-01-19" version="1" fragment="single">ISSRKCKRECASASRSESSAFRQTRNLPFKITADEMYDVFGKYGAIRQIRVGTANDTRGTAFVVYEDIFDAKTACDHLQGFNILGRYLIVLYYQPNKVTKKANLQKKEAELQELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVW4</accession>
    <name>A0A8H7PVW4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">triacylglycerol lipase</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">INT43_008885</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVW4"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033993529" description="triacylglycerol lipase" evidence="19">
        <location>
            <begin position="21"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="20">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG2181302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="427" mass="48238" checksum="B4DB00D5A45C2E8E" modified="2022-01-19" version="1" fragment="single">PMLKTFTFIVLLGTCLISKASVLRDDQLSFHQGAMTTENMVLQSQYRDNPDNWYTMDRMDIRAEAGPQPIRLNTYPGIYTVPSKEYIDGMKAATTPRTMFSVLDREHAWRPHIGVLPNVKSRETVLALAQMANNAYSSNDQDKDWRDVDGNWNTVRQIANSSYGYDDSGVRAQVFSNRQKSLYVIAIKGTSAGLWPGPTNSNDKLNDNLLFSCCCAHSNPAWQRVCDCFTGKRNECNKDCLRDSLLDRNLYYRTAMEIFFDVYEQNPDASVWFTGHSLGGAVASLLSLTFGNPAVTFQAPGERMAAQRLHLPPHGRPEWRYPIWHFGNTADPIYEGVCTGPSSVCWLGGFSIETRCHVGRTCVWDTVGENGWRVDIQAHRISVVIDEILKKSESEFPMPECEYERDCADCSLWKFVDSIVNGTETRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PW37</accession>
    <name>A0A8H7PW37_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">proline--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_008733</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PW37"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00779">
        <property type="entry name" value="ProRS_core_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000066">
        <property type="entry name" value="Proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050062">
        <property type="entry name" value="Pro-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033730">
        <property type="entry name" value="ProRS_core_prok"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753:SF2">
        <property type="entry name" value="PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="61"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2181151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="639" mass="71808" checksum="6551132C97F904D8" modified="2022-01-19" version="1">MFLQSVSKSWHHMRGVRCTSSMTPRNRLSKMFMPTSKEKVSASNADAVASHSLMLKAGFIRQSSSGIYSMLPMGLRTLEKIENVIDEEMKAIGGQRLALPLVLSSELWKKTGRWDKMGGELFKLQDRKESDLLLAPTHEEEITHIVANELSSYRQLPIRLFQIGRKYRDEMRPRSGLLRGREFTMKDLYTFDESIETASVTYDEVQGAYQRIFERIGVPFAVAEADTGNIGGFRSHEYHVLSSVGEDSLLTCPTCSYTANEEKAIGKIPAHEQHKVVEANDNTKQTDNVLDQMINDWKNFLLASVTASATSGKDNDTVFEETAMVSVYSHSERDINILKVQDFMRKTMENKAAQQGDFSQVNFTFTPIASNHQDFKTTGDLLNKKQNVHVLHDESLLNYPWFSLNKKREQWKQAMDVVNTPVTVHDLGDFRTAKEGDLCSNCTTHNISSQLVMNKAIEVAHTFLLGTRYSKTLDCSFTPREPVTGGGKLPVQMGCYGIGVSRLAASVIESLHDERGMVWPTSIAPYRVCILVADTRSDESNTIADDLYDQLNGQPSVSTHVLSDQVILDDRKGGFGFKIRDAEMIGYPFVVIVGKKTLNDGKVEIKERRSGQESHQVELSIQEAVSYLKTRITDQLTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PY89</accession>
    <name>A0A8H7PY89_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_007392</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PY89"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.850:FF:000001">
        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="99"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="209"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="421"/>
            <end position="425"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2182462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="537" mass="60033" checksum="9FDEB6138A1CDC79" modified="2022-01-19" version="1">MVSEFLQQEEREFQQQVDQLKQWWSSDRFRLVKRPYTAEAIISKRGTLPIQYPSNDQAKKLWSLLKNHKKNGTASHTFGALDPVQITQMAPHLETVYVSGWQSSSTASSSNEPGPDLADYPMDTVPNKVEHLFMAQLFHDRKQHEARFSVSKEERAKTPYIDYLRPIVADADTGHGGITAVMKLTKMFVERGAAGIHIEDQAAGTKKCGHMAGKVLVPISEHINRLVAIRVQYDIMGVDNIVVARSDAEAATLITSNIDYRDHAFILGATNTSLPPLVQVMYEAEQAGKSGDQLQAVEDKWIQEAKLARYGDAVAEVLKSKGHGSKVDNWYKDIEFRSNSEARTIAKKYGVEISWDWDLPRVREGYYRYQGGTECATHRCICFAPYADMLWMETKKPILSQAQQFSKGVLSKFPDVLLSYNLSPSFNWDAAGMTDNDMESYIKELGKLGFVWQFITLGGLHANALATATFAKGYAERGMLAYVAGVQRKEREAGVDVLQHQKWSGANYADELIKTVTGGVASTAAMGKGVTEDQFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYQ4</accession>
    <name>A0A8H7PYQ4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytosol aminopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_007175</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Release of N-terminal proline from a peptide.</text>
            <dbReference type="EC" id="3.4.11.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.</text>
            <dbReference type="EC" id="3.4.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYQ4"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00181">
        <property type="entry name" value="Cytosol_peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023042">
        <property type="entry name" value="Peptidase_M17_leu_NH2_pept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF23">
        <property type="entry name" value="CYTOSOL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M17 leucyl aminopeptidase N-terminal" evidence="8">
        <location>
            <begin position="49"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="7">
        <location>
            <begin position="194"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2182248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="57879" checksum="4A65BE0DC3A9E2A6" modified="2022-01-19" version="1">MLALRTATRHTRRTRYVGQLRLFSNKHNYDAVVLDAYSDNGRLALSQSSHISNATRTSILEQLQHSNFKNAGDVRVLYNAGGVKQVAVVNLGELKQLTHGDNVAGKRLEAARTAAATGVKALISQGVQKIGIDVTTSAHGAAEGATLALHSFDRLKNPKSRKPLIDVGPFLETVENVDPFLTWETGQIYGASQNLARSLMETPANLMTPKIFAEEIAYLLAGLEKVEVIVRDEEWAKRQGMNALIGVAKGSEEPLRFLEIQYKGGKEGDAPLGLVGKGVTFDAGGISLKPSNNMALMKGDMGGAATVAGALYGICKLGLPLNVTAVTPLCENLPSGRATKPGDVIKAMNGKSIEVLDTDAEGRLILADALYYLSSQHKPHSIIDLATLTGAMDVALGNVFAGVFTNSDKLWSQLDNAGQFMSDPFWRMPLHDGYLKEMRDSSVADLNNLGVGRSGGACSAAMFLKQFVSGIESPIQNISGDASLDDPVPQTEESDNDIAWAHIDIAGVMDSKHSNNYHVKGMSGRPTRSLVELARNLADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZF0</accession>
    <name>A0A8H7PZF0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZF0"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2181951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="130" mass="14164" checksum="6A3BA9A19AC5626E" modified="2022-01-19" version="1">MSGVKEAVFSKKAAPIGAPYSQAIKYNGMIFCSGTTPVNPQGELVGVKEKDVQAQTHQVLKNITGLLEDCGSSMEKVLKVNVFIKDMNDFKAINDVYATYFPDPKPCRTCVEVARLPLDVLVEIEVIAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZH6</accession>
    <name>A0A8H7PZH6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TFIIS central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_007466</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZH6"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21538">
        <property type="entry name" value="SPOC_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012921">
        <property type="entry name" value="SPOC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07744">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS central" evidence="6">
        <location>
            <begin position="97"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="122"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="407"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="599"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2182535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="632" mass="70342" checksum="BFCE26D0BA6F61DF" modified="2022-01-19" version="1" fragment="single">DEELPESPKGRERLKSSTPGKCLLTSCSKTARPESLFCSENCATDHVNEKATTRRKSRTTQSPEYSATRPSTGKESSKKKQPTSAGPQTIANENDPIRRNVTKSLTATLKGLIEVALKKDPTLFNPDEGVNSPSESSAAFDTDKVEDNGAATTEKEDVARSENATEKAVATSPPSAMHIAEKLAADIETAMFQHLAESHPKFPASKPQMCGEKYKGKFRSLLYNLKDKANEIFQLRVITGDLMPENLVSMSGEDMANPELKSMSETLRQKSIKNSIMKVQNIPIIKKTHKGDIIMMPSKDNSNADDSAGIRSPLVKLEEQKPEGDASRSPSSRKSSLSVSTPKSPSVKTDSLDEILARMTNSNDQDQESRKRRADGTNSEERKKRKIDMEKLLGDEDVQLEIGSDDEGIITSSMRNSHDHMNVEEPSSFADSKASPKSPRVPKDYSLQPIWHGKTIMQQVAEFESYAYQIGGRPLSQDAWSDIFTPTIWIEGRIPTDRVTDYLTQTQFSSSKELILIDIKSSQEVGNQEADNLLKYFHSRNRYGVVARNKTTIKDFYIIPLTEQDQLPDCLVALNHDLADTGRNRDMLLGVIVLNKKLSSDSHSPHERHQRHNSMSKRPFEPVTKQIPEPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZX9</accession>
    <name>A0A8H7PZX9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Inosine triphosphate pyrophosphatase</fullName>
            <shortName evidence="12">ITPase</shortName>
            <shortName evidence="12">Inosine triphosphatase</shortName>
            <ecNumber evidence="12">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="12">NTPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">XTP/dITP diphosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_006543</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:29400"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-hydroxy-dATP + H2O = N(6)-hydroxy-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83971"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:233529"/>
            <dbReference type="ChEBI" id="CHEBI:233530"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:83972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>XTP + H2O = XMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:28343"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="12"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZX9"/>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009204">
        <property type="term" value="P:deoxyribonucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000003">
        <property type="entry name" value="Inosine triphosphate pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03148">
        <property type="entry name" value="HAM1_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027502">
        <property type="entry name" value="ITPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00042">
        <property type="entry name" value="RdgB/HAM1 family non-canonical purine NTP pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="68"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="144"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="172"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2183537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="191" mass="21193" checksum="1F74A3B5C58E7A9E" modified="2022-01-19" version="1">MLTCSRHSVFVTGNKYKLMEVQAILKGTVDLESHKVDLPELQGTPEDIAAEKCRIAAEKLQGPCITEDTCLCYNAMNGLPGPYIKWFMESIGHEGLNRMLDGFQDKTAYALCTFAYSKGPGHDPVIFDGKTPGRIVPARGPPDFGWDAVFEPDGFDQTYAELDKDVKNTISHRFRALEKLQAYLAAEKASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0R8</accession>
    <name>A0A8H7Q0R8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0R8"/>
    <dbReference type="OrthoDB" id="10400709at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2183812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="118" mass="12313" checksum="7F01DE1F91F2BEB5" modified="2022-01-19" version="1">MLAAVTGHVAYRPRCHVKVRLVQRTLVAVFATAVQHAKAGSVISSELLRNNTGQVNYFIGACVQPALPDGLSLALDNSTGFVTLAGTPSVSSLPVNYTVIAKGGVNYIGTLNFTLSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0T8</accession>
    <name>A0A8H7Q0T8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_006727</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0T8"/>
    <dbReference type="OrthoDB" id="540503at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034981762" description="Nucleotide-diphospho-sugar transferase domain-containing protein" evidence="3">
        <location>
            <begin position="31"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="4">
        <location>
            <begin position="101"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="576"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="612"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="525"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2183716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="626" mass="72308" checksum="2B56D661200AC813" modified="2022-01-19" version="1">METRTRRISGIGLMVLVLLMSLLYLSTSYTQVVGQVSSQYSEDVQIPITNQMSLEFPEPNEQYMNKIRSQVVQDNVLVIATANYGMRDYVYNWITSLEKTSHDKYLVFCIDDDLYTHMEASGYGDHATKIPAEWFHKPIEASFSDYYSPTYAAITHAKTLVVQRLLYLGFTVFFSDVDIVWLKPHIVDFLAGRLSVREETEVLFQQEGYDQMNINSGFYIMRPTDKMKQLLLDTIVLQDTGEYTQQGAMNQALNNLDMDMRTSAVVLLDLFMFPNGFAYFQNDVPQRWGIEPYIAHANYLLCSLSPQVADEKRDALANHGLWYVDQTKLEKADAIVESKQPKKTKEHLSMTTAAEDTTSTTEYNAPLRRLYPGSRVEDTFQWPSLALDDIESSFSVQEYLQQLIREDYTDIKQLIQLPEGMDSEIWQYEHLRQLCLQLNYLIPSLETECTSETCPEMKADGWLYLCAAHPITKSCPAIDYVVHTLDGATMLLNNSKYFPSRISIPEPSLKHLQAIARRLYRIFAHAYFHHRETFEFYENETYLHERFLRLSQKYNLIPKSLLIIPHNTDEDEEVQDASDDLKVNLSRRSSTSTVQEIAESDDETVHAREPTNEQQNQDSDSVNLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1D1</accession>
    <name>A0A8H7Q1D1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1D1"/>
    <dbReference type="OrthoDB" id="2235872at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2183568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="102" mass="11357" checksum="C733BD4E8FF6A73A" modified="2022-01-19" version="1">MQNLDIQNLYEAAVDELESASEDCVVAIMHCIHLLLQTPFDVSLEMIQSCVDYALEMINGSFTQSNTFPKIVTAAIDMIFQEPLLANHDLNEDDGPIKKVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1G0</accession>
    <name>A0A8H7Q1G0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin interacting protein 3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_006786</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1G0"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005519">
        <property type="term" value="F:cytoskeletal regulatory protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005613">
        <property type="entry name" value="AIP3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00806">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Actin interacting protein 3 C-terminal" evidence="4">
        <location>
            <begin position="185"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="639"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="420"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="645"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="663"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="681"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2183775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="702" mass="79370" checksum="EECBD6D0FD21BAC2" modified="2022-01-19" version="1" fragment="single">GSDSRPLSPHSNRSESPTPSTSTSGDRLLRQQSGHLQRSSSPTPPRSFNPLPVPQKEYSGDFDMNDPKTADALAALNKQENLARRSSVRRASALYRTTSTASRSPGRLRYGSDPKTRVPPVPTLPDQLSPDLPVVNAYDDSERNEDLSSNVSVDRGKEANDDQRINSTSITFDKDREDSGAMDLYLKLGKKVKKVEYNGPVELSSLRMLFIEKFQYIARNDEFPAIYITSPSTHISYELENMADVQHESLLTLEIEEPEATNLGQQISEQITTGFSSMTKEMSDVRQELLAYLKATYEKAPVEDKAPETVPAKIEPVEEPKKAPVDENVKTEPVMPAIKEEITSSTKPISDIDLSLLKEVKSKLSQVESIRRDMGVVRQLHDGFRAEMQGLMGGLREKSSQLKVQPVNLSGARKFVDEGKNELDTTAEDITKRLEDLQDTIDELKLDVTARKCRPSSTQMQHCDQEAKNLQVDITKLADKLQTVKPMWKKTWEEELQNIVKEQQFLKEQEALLEDLQEDHAAILEVFEQLSKIREIQEKSKSGPRRQFRITPIDSGHEGMTSVLKQVTTIDVDPERRLRALNQAEKMRERELANRIDEFEEELTNFVGTKRLRMTGGAQEIERQRQKKNQNMLRQLYEKKKGNEAGTSQDTQDGQTSGNDSDAQDKSDEIIEDKVNEDEDVAGREDENIKEDEHSEPQNEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1M4</accession>
    <name>A0A8H7Q1M4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA repair protein RAD50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_006714</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1M4"/>
    <dbReference type="OrthoDB" id="18797at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000947">
        <property type="entry name" value="DNA repair protein RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13558">
        <property type="entry name" value="SbcC_Walker_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2183703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="27679" checksum="120DEBCAEAEC3D90" modified="2022-01-19" version="1">MAILQEQQADIINKRGGLQGELRQMQDQIERYNSDLNNEYKDIDKIYRKIYVGVKASEMAIADMSKYALALEKAIMKYHALKMDDLNKIIKELWINTYKGGDIDYIEIQSDNEGPASNRSYNYRVMMVQNGHKMQMRGRCSAGQKVLTSIIIRLALAETFCINCGILALDEPTTNLDRDNIESLANSLASIIRARRQQANFQLIVITHDEEFVDFLGRSDIAEYYYRVHKDQAQHSVIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1M8</accession>
    <name>A0A8H7Q1M8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome maturation protein SDO1/SBDS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1M8"/>
    <dbReference type="OrthoDB" id="2567806at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="110" mass="11882" checksum="15F40EE54876E2C2" modified="2022-01-19" version="1">MPEGTPVRVTYKVNGEEFFVFADHEALEKWQKDKTIPLVEVAASFEVLHIPNGGNTGEAVRPSKGELESAFNTSNSDDIVKKILSEGEVKGSVHVDKGNAYGLGGNKGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2K1</accession>
    <name>A0A8H7Q2K1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA-directed RNA polymerases I and III 40 kDa polypeptide</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_000574</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2K1"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000003">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000005">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="8">
        <location>
            <begin position="60"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00081520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2184661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="347" mass="39121" checksum="37B5A3C7CDB46BDA" modified="2022-01-19" version="1">MSLPEQLETLRSRVVIEKDSVHNVSSSDYPHQYPGIDDSWDLEKFKKQFQVKINRLSDLEMEFDLIGVDASIANAFRRILLAEVATMAIEKVYVMNNTSIIQDEVLAHRLGLIPIKADPLLFDFKGEEEGPTDLNTIVFKLNVKCERRDGVSKDETDPKKMYHNSEVYSKDLIWEPKGEQAERFKDDSVRPVEDDILIAKLRPGQEIDVELHCHKGIGKEHAKWSPVATASYRLLPEIQILKPITGDDAVKFQKCFPEGVIAVIEEGGEKVAKVVNARKDTVSREVLRHKEFEGKVKLTRVRDHFIFNIESAGAIPPQDLFVQAVGVLIEKIKAIKPALAQATGNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2Y1</accession>
    <name>A0A8H7Q2Y1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-1,3-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_000866</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNN1/MNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2Y1"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2184953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="64865" checksum="EF5D2DD4720D5CF3" modified="2022-01-19" version="1">MPQSWDLSRHIQLAVLLLILIVMVAFTMRADFWDQWSSAKTVSKDFAEMEQNLAKQAEAIRIYEENQRVAKLKEFEQRRAVLEPVILANDSDLKALFETHDIAVPYPSRNWQLINTDYLLSLAGQSDWANLLTTPEDKPDFKLMTLQERTYKALFQFLDNLQAQGANIYEDPYRETWELFRQLERVLYPWLHLKYNSLFDVQAEQKGAGMIFCVGNDQFFHAASTIRAIRETLKSAIPIEVFYINENDLDEVKREYLETEFTDLRTVDLSKEIDDTWTQFGGWAMKPFAIVASSFSQVILSDADVFFFKKPETFLEDAGYKKTGALFFYDRTLFADWDGGRNWMLSFLPTMSSLVRKTRWFRLRSSHEQESGVVVIDKRKSILGLMSTCKMNDKRERDGVTYDHVHGDKETFWVGYEMVQSPYSFINSFGGVIGGLGDGGEPTRVCGNQLHLGVDGRPWWWNGGLLRDKNRWPDRYMQFTHFAVGEDWDFETSCIIEEDGVKALTKQEIALTDGFLTIDEQRKKDQLAMSQGLWKPKPIASAYDVGDFVKNPTIVEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3C2</accession>
    <name>A0A8H7Q3C2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SART-1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_000693</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNU66/SART1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3C2"/>
    <dbReference type="OrthoDB" id="5583at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000481">
        <property type="term" value="P:maturation of 5S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045347">
        <property type="entry name" value="HIND"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005011">
        <property type="entry name" value="SNU66/SART1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152">
        <property type="entry name" value="SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152:SF5">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19252">
        <property type="entry name" value="HIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03343">
        <property type="entry name" value="SART-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="487"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="651"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="489"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="662"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2184780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="675" mass="77227" checksum="178A347594A9200E" modified="2022-01-19" version="1" fragment="single">MADAEELSLEETNRLRIQAGLAPLGEDTEETMDEDQVAYNNYQQLKEEKEMAKKAKEVQVRIEKAKNRMKATEKLKGKGLGEASDDEDSAMKWIKKSRKREKALAEKRARELAEMDKAYESVNYDSADLSGLKVAHDLAEFDDGGEVILTLKDSGVLDEDEDGIQLTNVNLEEREKLRKNLDNKKKKPGYNVYDDEEFTIGGGAKNILSQYDEELEGPKRTSFVIGQQGRIAADPLKVERASVAEKLKAQAVDLKYEKMQEVKDYYTQEEAALTFKKPKKKKKVRRKAVEADEEQTNENNQALAEMEGQAMVVDEQSTPEAAVKRLDEENFVDDDDLQQALARARRVAIKKKQSTKRMTAEDIANSIAQQRAAEQEQDNAEDTESGGLVISDTSEFVNSLSMDAVIERERRERERLEAEAAQEQASKIVTEMELDNDDIEMANTEIEEEAKEPAKEEEDITAVVDEPLVSKGMAATLALLNQKGFIAKPNEDQIQREKVAASRARWAAEQKRKDVQKERERERDRLRDKERDKGRDRGGREYEREREHEREVEKERRERERMKEYEQRMRDYKPDVNIEHIDEFGKAMTPKEAYRALSHAFHGKKSGKTKTEKRLRRMEEEHALNSMGSSDTPHNLAAAMIDRQERTGSAHVVLSVGNRGVIPDRDNEASKKRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3X6</accession>
    <name>A0A8H7Q3X6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3X6"/>
    <dbReference type="OrthoDB" id="2440287at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034168088" evidence="2">
        <location>
            <begin position="40"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2184860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="290" mass="30527" checksum="A218DFD7F8A18D32" modified="2022-01-19" version="1">MKLEHNVSSSSRTDFSAVPRTRYALVVFLLLIFSFACSAKPSHSTASTSTPTPTHSTNNNKVAGTTDITTTTTSSSGWLLEPFFAPKKAQSKSSTTTIVTTTTQKIQGIPLPQFSPIFPRPQTSTTSTTTTSVHKPTPTETPSTTTATSSKSKQTTQTSDTKTNSPPHVPHFTSSEASSTTTTVSVTDDPMVSVQMVEPSTTVAGTQTITLGIPPQITNPTAPHGELNDPSSPTVIVLVPPSSQNEDTAPPKQIIVLLKGDKGVVANAASVLTLRLDTLLLAGVFLSVFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4V6</accession>
    <name>A0A8H7Q4V6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4V6"/>
    <dbReference type="OrthoDB" id="76224at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013240">
        <property type="entry name" value="DNA-dir_RNA_pol1_su_RPA34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08208">
        <property type="entry name" value="RNA_polI_A34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2185987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="169" mass="19100" checksum="09C15B2236098954" modified="2022-01-19" version="1">MQISPSELTGMKFKLPAERSPGKSLGKLSAHSSYYSLYRVPEQLEETDENIICGGQEMSGFRCLVPYMKRKGKLGFAPKPIKHQLILDEKVEIPDPTEIGEQIKNTPWPIREQPEGMKMRFKPYGFDTGDSVDSAAADSNKEKKKKDKKRSHDDDSAEKKSHKKKKATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q509</accession>
    <name>A0A8H7Q509_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rad21/Rec8-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q509"/>
    <dbReference type="OrthoDB" id="2446053at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2186003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="367" mass="41926" checksum="E6E28816B8037E92" modified="2022-01-19" version="1">MLPLEDVLQSRHQEFRLIWDASSVSLTSALKRARKLRKSILRLKVDQNCHYLSRMETALPMCLQSGLLNGLAKIHHQQCQDLYNNVQSTLLHLNRSLTSSKMSVIDSDTTIARHIANDAQFTNIELLDLHNAHPFENMVAHRYHLLDSMVNEQPYPLATSNINEVIDHNQELVEAPPVNLLPATSLNATELEFDIQEYSSIDDNDQFFLSPVWQYGRNTPESDETVAVQRDNDNLWSLRQQFVLYAVMRDSTKYLNVTAYRVGAMNQIQLPGAHEPIEPHQLSRIHEVVNEAGVSYVSNMARQSKSPDVVIHGNTTEDKNDNSYDTITDPYELEELGVYIDHDKWEAPSEDRPNNRTKSATDTRHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5B4</accession>
    <name>A0A8H7Q5B4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Srp40 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5B4"/>
    <dbReference type="OrthoDB" id="5599646at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039191">
        <property type="entry name" value="Nopp140-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007718">
        <property type="entry name" value="Srp40_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216:SF1">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05022">
        <property type="entry name" value="SRP40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Srp40 C-terminal" evidence="2">
        <location>
            <begin position="303"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2186387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="382" mass="40921" checksum="5597F1A766C4AD2A" modified="2022-01-19" version="1">MAPTNSALDALVYQYLVDMDYKDAAKALKKKLGSIKETDGEKLVEFYKKHSQSNDEEDSSSSSDSGSESDSESESSSSESESENDSSSSESEESDDDNEKDVAMTEKVAVASSDSSSSESESSSSSDDSDSDSSSDEETEEAKAKSESSSSSSSSSSSSSSSESESEKKDSDSSDSSSDSSSDSDSSSSEEEKAKAESSSDSSSESESDDSSDSDSSSSEEEKGEKAKSSSSDSSSESESDDDSSSSSSSSSSDSESESESEKEAAKVSVKRKQESPETSSASSNDTAVETPAQKKQRTQGERFQRVKAEDVNFYDDRLRDNSYVSKGGSDDRSYGWKAHQDLIVTRGDKFRAEKNKKKRGSYRGGQIDFQSHSIKFNYDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5E9</accession>
    <name>A0A8H7Q5E9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent RNA helicase DOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_000939</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5E9"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13154">
        <property type="entry name" value="KOW_Mtr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000002">
        <property type="entry name" value="superkiller viralicidic activity 2-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="180"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="414"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="21"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="381"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2185026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1089" mass="123237" checksum="DA7444D9B02F8390" modified="2022-01-19" version="1">MFDEDGEALFDVFGSEVPISEFTTGELSSGTDHTAEKKQSLNKQQQQNADQHSKDLAHKRSLQETESTNVEVDTDMENGNMKEDFSGHPSKKFKATEEAPQPIVADEFEQESTREVANIPGLQSSSDADNQTGVILSHQVRHQVALPPNYPYVPISQHVPPKDPARSYPFTLDPFQRVSISSIERNESVLVAAHTSAGKTVVAEYAIALCLKNKQRVIYTSPIKALSNQKYREFQEEFGDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSEIMREVAWVVFDEIHYMRDSERGVVWEETIILLPHSVRYVFLSATIPNAMEFAEWICKIHEQPCHIVYTDFRPTPLQHYLFPAGGDGIHLVVDEKSNFREDNFQKAIGSLADAQGDDPSNPQSKPRKGGKSNKGGQKDGPSDIYKIIKMIMMKNYHPVIVFSFSKRECEALALQMSKLDFNDESERDMVSQVFRNAISSLSEDDRQLPQIEHILPLLRRGIGIHHGGLLPILKETIEILFQEGLLKVLFATETFSIGLNMPAKTVVFTSVRKFDGKDTRWVSSGEYIQMSGRAGRRGLDDRGVVIMMIDEKMEPAVAKGMVKGDSDRMNSAFHLSYNMILNLLRVEGVSPEFMLDRCFYTFQNNANVPRLEEELTQKEAEKMSMVIPEEDNIASYYELRQQLDTYSKDMRDVINHPAHCLPFLQPGRLVRIKHEDMDFGWCVVVNYQKQIQKGKNVDGSDKEPKYIVDCLMHCLAGSVVAKNADGSTVGIRPPKQGEPGEMIVVPVTLSTLDGISHVRLFLSNDLKPAEERNNIFKSIMEVKKRFPEGIPQLDPIENMGIKDEGFKKLVRKIEVLESKLLSNPLHNSPELSKLYDSYAKKMELSNQIKAIRKQITQAHSIVQLEELKCRKRVMRRLGFTSAADVVEMKGRVACEISTGDELLLTELIFHGVFNDLSVEQSVALLSCFVFDEKSEETPRLKEELEGPLRTMQEVARRIAKVSQESKLNVVEDDYVKKFRPELMDVVFAWCQGAKFSQICKMTDVFEGSLIRVFRRLEELLRQMCSAAKSIGNTELENKFAEGINKIHRDIIFAASLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7K2</accession>
    <name>A0A8H7U7K2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_004314</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TALE/TGIF homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7K2"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000059">
        <property type="entry name" value="TGFB-induced factor homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="97"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="99"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="66"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2174291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="191" mass="22318" checksum="6E49898F5B5BD6C9" modified="2022-01-19" version="1">MDYYPQRRVFSPIILFHENDTIRDDDPYRQSMLQPHKDRISHMLECNERFWRDIKQTNHTAPLMLNPNLLIDNPESSSSASSNSPSPSTSDDLADIQSHKRRRGNLPKPVINILRTWLINNKRHPYPSEEVKRHLARQTGLTKSQISNWFINARRRILKEMIDVSQDGNPLAKGRRLPRGKRANSSDDQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8H4</accession>
    <name>A0A8H7U8H4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_001489</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8H4"/>
    <dbReference type="OrthoDB" id="660759at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2172012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="250" mass="27727" checksum="836A397C7CD2D592" modified="2022-01-19" version="1">MSSSAESNFRNSLRGFNSTPRSGGIQLPTTGNQEGSALGRTWASFTSGATDAFDNARRTVQGYVPVNAQEEVDEPWFQMSRWEVSYHISTMPSFMPRLTQYVPAIDGLCVMRGAWNSMFRHGELSFYGCQYWPSSPVNSLPLSHVSKPMLHGMGSILMLISVALLRGPWAHVKHMMSLERLPFTAAYLGTMGLTLYFSLGARNYILTIISAVLQIIALLWYFGSYIPGGVATLRYGSWMVGRQASSLLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U998</accession>
    <name>A0A8H7U998_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">P-type ATPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_008229</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U998"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF180">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="6">
        <location>
            <begin position="136"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="5">
        <location>
            <begin position="264"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2171503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="52321" checksum="EB83A12B5D2DBA69" modified="2022-01-19" version="1">MSKSGKIDSDEISCIAGKITFITHAKLGIFLCLFFPMSYRRSFKDWYYQRKWFQHHPQPDGTSSIDDAYDEERSTRSQSTASAHPPPPRRASTNMSLRKGDQFLRRPTNKVKLRKIQKGGRRVFVNLPIPKSDQNAKGAPKQAYASNRIVTSKYTMLTFVPKNLFFQFSRLANVYFLGLAILQLLPYFGIKSPVLTLLPICSVLVISAVKDAFEDYQRHTLDRKFNNQIAYTLAGYHNVNYSTDSPAKKALNLDKSISSLDHIEGKFHPSHSEDVRVGDFLLLRNGDKVPSDCVLLASSDETGVCYVETKDLDGETNLKPRQSMSETLQIQSGQECLDLHFYVEAEAPHPNLYHFDGTLVMLRKLNPPVAESAGRTSNITWEERSKTPISIDNMLLRGHVIRNTRWIIANVVFTGVDTKIMLNSGETPTKRSEIEKELNEEASYIKERQWHEKKPKQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9C3</accession>
    <name>A0A8H7U9C3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9C3"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051604">
        <property type="entry name" value="Ergot_Alk_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162:SF1">
        <property type="entry name" value="PRESTALK A DIFFERENTIATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="2">
        <location>
            <begin position="19"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="382" mass="42038" checksum="D121104D2AE0F759" modified="2022-01-19" version="1">MTSPMLMRSFSAPCSSDGKGSIYVSGADGEKGSHIVQQLLDLPQRHPHLPAYPVYAGMPNATTANGQALKKKGAHLIQFDIFETPELVVEALQGMAKLVLVVDPLSDRITRNNAFHYAKTYIDAAKQANVSHIIFLTPFSPLDPSTSPNVTPPLTPPSSEGDKRRLSLSDSSSYRSQFMMMESHLQLQFPASQITILRYPGILHQHLSFFAKHINTHNRFPLPSKQLQITVESCNMHDIARAVSFIAFSPTTRHSSNVYKLTGPQLLTLQELSERVSAGLGRDLPVDAMDMRSLKHVLSETMGSDDKVAFLLEMWGLQQRLEGRRFEVTRDLELLTGQSGKTIGEYFKDDNVKHIFTPVGAGPHPATQSPTAAATVPSQPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9E3</accession>
    <name>A0A8H7U9E3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphoglycerate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_007858</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9E3"/>
    <dbReference type="OrthoDB" id="418179at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12176">
        <property type="entry name" value="PGDH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000041">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050418">
        <property type="entry name" value="D-iso_2-hydroxyacid_DH_PdxB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008759">
        <property type="entry name" value="PRK11790.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="33"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="138"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2177201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="48693" checksum="45B7F975564E0B44" modified="2022-01-19" version="1">MSDPIEEPRQRRASLQQQKPKLLRPFNTSEVKILLLENINQTAIDAFKKQGYQVETYPKALVGEELIEKIRDVNVIGIRSKTKLTKQVLDEAKNLIAIGCFCIGTNQVDLKTAAKNGISVFNSPFSNSRSVAELVIGEVIGLARQLTDRSAEMHQGIWNKVSSNCFEIRGKVLGIVGYGHIGSQLSVLAESMGMTVYFYDVLQIMPLGTAKQVATLEELLSISDFVTLHVPELEETKNMIGEREIMGYMKKGSYLLNNARGLVVQLPALAKALKSGHLAGAAIDVYPKEPASNGNHFTDYPELLECKNLILTPHIGGSTEEAQSMIGIEVSSALTKFINQGTSINAVNFPEIDLRIINEEESNTVRVLYIHQNIPGVLKVGVPEINEVFANHNVDKQYSDSKGEIAYLMADITQVTEEQIADLYNRISSTRANIKTRLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9F4</accession>
    <name>A0A8H7U9F4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_004676</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9F4"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2173302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="517" mass="56952" checksum="BFFFBCB49CCEAC19" modified="2022-01-19" version="1">MQTYTVEQVAAHNNDKDCWIVVDNKVFDVTKFLSEHPGGKKILLKVAGKDATKQFHQFHNAQIMESVGLPLQIGVIGGAEQPKAAPKAVAQEGNKVGDLIPYGDPADCQDWNSPYYNESHYKLRRFLRAFVDKELMPHCHEWSEKKDIPRSVVKKCAEIGLLAAACGHVPEEYIPYGLPAGIKAKDWDCFHEMICVDEIARCGSGGLLWGLQGGLSIGLPPVLLFGSKELQEKVTRPCLSGDKFICLGITEPSAGSDVAGLKTEAKDMGDHYLVNGEKKWITQGLDADFFTVACRTGGNGMGGVSLLLLERTMPGVTTRRMDCMGMFGSGTSYITFEDVKVPKSNLIGKENQGFSYIMQNFNHERLGIVFQATRLARVCVEESIKYANKRMVFGKKLIDQPVIRNKLGHMVRQVEATQSWLESTLYQVKTLPPSAQPKALAGPIALLKAQATQTFEYCAREAAQIFGGLSYTRGGQGEKVERLYREVRAYAIPGGSEEIMLDLGIRQAQRGLGNAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9H4</accession>
    <name>A0A8H7U9H4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GSKIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9H4"/>
    <dbReference type="OrthoDB" id="5804279at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007967">
        <property type="entry name" value="GSKIP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05303">
        <property type="entry name" value="GSKIP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSKIP" evidence="1">
        <location>
            <begin position="8"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="163" mass="18196" checksum="A17C2CE7BE996392" modified="2022-01-19" version="1">MRASSLSKELESITKDYDFGIVPGSAAIFVKDEENYMGRLDLTILEGILVIIEVTDQGYKALSCSPIFTMETTKPVLDHIESVLYKPFETMESLLMSISPMFREKFQEALYNKLANINSEPSNSSESQQQEFQNNIGQEGMSQEALMALLNNDPADGLGAPWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9I5</accession>
    <name>A0A8H7U9I5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_009150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9I5"/>
    <dbReference type="OrthoDB" id="2449232at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="49371" checksum="9964CE4ABBAE5993" modified="2022-01-19" version="1">MPVTVSTETHTTINSPQREKTTTSKRIETTTESSGHTETSSKTTTTANSPTTTELPDTTQVATTTTADPSTTSQDRSTSTSDPLTTTIDSQTSISSEAVVTTTTESSSSDSPTITSASVVSTTDSVTQTTASESSTESTSSPPSSTTPPISSTLMESSATPTSSQGVTTEATSTSLDPTTTSSEVITTTEATITSEATTTAPPTISSDTLTPTTTSDVITSSSMSTTSDIIPTTTSVPSSSSDPPTTTTEPITTTEMPITTEVPPTTTPPPPTSTIETSSDVQTTTSFVPPASSTPTPDPAPSSTVTSVTTMTTQVSTQAPATISTHFSTSFLTISSNMPVTRTSTLADGEVILVTTVIPTVYVTPSLVANIESVGNNNNTGPPAAIIGGVVGAAAGAAMLITGFIFIRKRRSHLQKDNDTESTYAASFGVDGFPATGEDMNGSENRSSNSDWLSILRRNRQRPERQSEFMREIFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9Z9</accession>
    <name>A0A8H7U9Z9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9Z9"/>
    <dbReference type="OrthoDB" id="2352727at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="69" mass="7948" checksum="F8CD6BC4593998D1" modified="2022-01-19" version="1">MSSVYQSKQTDSEKKSQEQELIDNARYHTELETAKDDAQRASDVHEERTGKSLDISDKNVMEGEFPEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UA12</accession>
    <name>A0A8H7UA12_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Post-transcriptional regulator MKT1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UA12"/>
    <dbReference type="OrthoDB" id="17262at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022039">
        <property type="entry name" value="MKT1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12246">
        <property type="entry name" value="MKT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Post-transcriptional regulator MKT1 C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="223" mass="25383" checksum="1EE7E14820C4A86B" modified="2022-01-19" version="1" fragment="single">HKPTHWGTAFIAAATESNQEALLSAFELIRFDILTSKEYSRSYDVPVQDKHLGDSAKHIRLISRTVSLVPMTFKHDVPFVGQMYRDVLVFNSFVKALNRSYRNLCEMLLLSLFLNDCVKRDRRDYAELSIRLPYVSDINAATGMVAKSYLENTLKEESASKAVETTEKMYSTAIDLKAGLANGFEFWDQVMKGIKVLKAAKSFESTCDMFLEADAWLQGRRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAY3</accession>
    <name>A0A8H7UAY3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_004632</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAY3"/>
    <dbReference type="OrthoDB" id="10267976at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF8">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="3">
        <location>
            <begin position="283"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2173258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="476" mass="52226" checksum="A57A1540984D3CB6" modified="2022-01-19" version="1">MSKTSDVTKPLCSWIETLKWEDIPEEVRERCKFLILDGLGCAIVGSHLPWSAQAVEAVLRMESPGGDCPLLGWKERKTGPLPAALLNSAFIQAFELDDWHGLAPLHSNAIILPALLSLASHQKTVGKTVSGQDLLLGMITGCEVGPRVGLAVGGGNILSRGWHSGTVFGHPASAAACSKLLGLDKDQIEDAFGIACTQACGLMSAQFESSVKRMQHGFAAKNGLFSALMAESRYKGISTVFDRAYGGYLNVFTLGASEPAKPDEVLKDLSETWQLMNMNIKPYACMAGIHATIDCVKELQAKHTLEAQYIKKITIELGGPAFHHGGWQAERPLTEMGAQMNNAYIAAAQIIDHDINMKTFASANLNRDEMWELILKIQCQHREEVDQMPHHNKLCTRMTVQLENGQVLQSEVFHPKGVKKPLTSEEIIEKFCHLTTDLISPQGQQDIIQFVSNLDQVEDSSELFKLFNLDIPNPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UB54</accession>
    <name>A0A8H7UB54_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinol-cytochrome C reductase hinge domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_004558</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UB54"/>
    <dbReference type="OrthoDB" id="405848at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003422">
        <property type="entry name" value="Cyt_b-c1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034840833" description="Ubiquinol-cytochrome C reductase hinge domain-containing protein" evidence="10">
        <location>
            <begin position="17"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="11">
        <location>
            <begin position="64"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2173184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="117" mass="13099" checksum="B7585787139E4475" modified="2022-01-19" version="1">MALADLLSSFLPTVYAEEQPEEQPEEAVEEVEEEEEEPEDPKDAIMEGAKFSCQANIHHLPSVECQNSKECSKVKAHLDECTERVENGAHEDCIEEFFHFMHCADTCAAPKVFAATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBS6</accession>
    <name>A0A8H7UBS6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phenolic acid decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_003534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBS6"/>
    <dbReference type="OrthoDB" id="4415004at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14241">
        <property type="entry name" value="PAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008729">
        <property type="entry name" value="PA_de_COase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40087">
        <property type="entry name" value="PHENOLIC ACID DECARBOXYLASE PADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40087:SF1">
        <property type="entry name" value="PHENOLIC ACID DECARBOXYLASE PADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05870">
        <property type="entry name" value="PA_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2179751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="20022" checksum="CA87591D26D5EC33" modified="2022-01-19" version="1">MYVQEDFSSTKPAELKTVIGKHFIYTYDNGWQYEMYIKNAQTIDYRIHSGMVGGRWVKEQKAHIIRLSDEVYKVSWDEPTGTDVSVTINLQERHLHGVIFFPQWIAKEPTKTVCYQNDHFDNMLSYRDAGPTYPKLVVDEAAKITFLETCAPDDESVISCGIEALPEGYTARNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCG4</accession>
    <name>A0A8H7UCG4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_005880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCG4"/>
    <dbReference type="OrthoDB" id="5328412at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06552">
        <property type="entry name" value="TOM20_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="26"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="375"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2174818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="694" mass="78173" checksum="72162F0D5143038B" modified="2022-01-19" version="1">MASKKLVIEYVKQVEETPELRRSKKSDVLSMHYTGFFEKSNKKFDSSRDRKQPFEFMLGAGEVIKGWDEGLQDMAIGEQRKLTIPPDMAYGVYGVGPIPGNATLVFDVELLDIKEKRSHDASALMLPLLLLVALIGGLFYINFIGGTTKTARLPDQSTESRAIGTLQIMGRPKPTKPPKKEKASKKQAEPSTFEDFMEEGVELEEKGERYGDGEKSQRFYERAAEMYGKAHALNKKDSDCLYNWGRVLFVLLQFLPKRVDPMTKLKLIDSSIDKFRRALALESKNADAMFNLGQALNTRAETVQEVDEIEDGYNQAAIAVQEAISILEEAYTLQENELTPQLQDLSINEPEHQHQHEHEHQHDHDHDHDHDHPQGQDTESGSASTGDPSTTVTEVIPTTAYTLIDTLVATANAQSTMGSMLANYEKSLDLFNSAKDKLHQAEQWLGKASRENEKDYQQAVIQIALQRAQVLSLLADRTMTADGQVDDKSYTLALEQLDFVTSKVDPRHCEAMCDRGDLLSQYAQAKQQSYLRSGRKLDGDASGKEVWQLFSQASKSFQGGLEIEPKNSSILRKLGDLSLIRAQLPLTVAEKNKQQLLKNGEFYYKQVLESDKQDIYGAWLGWAASAWALGNWCADAGKRTEADKIIKMWMKRGGDVDVVQGAYEENDCFPKQFVDWVMVTYFDDEEEDDDDDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UD80</accession>
    <name>A0A8H7UD80_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_008909</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UD80"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051704">
        <property type="entry name" value="FAD_aromatic-hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865:SF2">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="5"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2181326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="405" mass="45758" checksum="8EB28569E96731B5" modified="2022-01-19" version="1">MAPLKVLICGGGCAGPALAYWLAREGHSITIVERFTALRATGAQIDLRAQGIQVVKRMGLLDTIRSKRVEERGWSYVDSQGRTKATIMSNSSGKGAQTATSEYEIMRGDLVRILYDATKENTKYIFGVTIESFEQYDDRVVVHFSNGCSDTFDVLVGADGQGSRIRKAILPPGAEPFRRLGVYMAYWFVPRTEADSEFSQSYHCPGSRMITSRSHSETETQAYFVLKDDSEELRSIPKAPIQQQKEFWTQRFRNTGWQTDRFIEGMRTAENFYCQEIVQVITDTWYDNRVVLLGDAGYCPSPLTGMGTTASFVGAYVLAGEIIRNPQNLSQAFANYQNILQPFIKEVQNINPWMLRLGLPQTQWGINIFQSVVGILCYLRVFELIARFSKEEVGGWMLPDYPELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDQ9</accession>
    <name>A0A8H7UDQ9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_002060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDQ9"/>
    <dbReference type="OrthoDB" id="415358at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040577">
        <property type="entry name" value="Gln-synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052725">
        <property type="entry name" value="GS_Type-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022147">
        <property type="entry name" value="GSIII_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42974">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42974:SF1">
        <property type="entry name" value="TYPE-3 GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18318">
        <property type="entry name" value="Gln-synt_C-ter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12437">
        <property type="entry name" value="GSIII_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="3">
        <location>
            <begin position="91"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="4">
        <location>
            <begin position="197"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2179210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="758" mass="84793" checksum="FF5CF2A6D21B75A9" modified="2022-01-19" version="1">MSANARVNTVTETISRESRNVQYPQKNGKVQWISEIFGQNVFSLNEMSKRLPKPIYSTFLKQIRGNEIIDKTTADAIAHAVKVWAMEHGATHFTHWFQPQTDSTAEKHDSFLTLKSTFRGGYEETTALDTFSGSQLLQSEPDASSFPSGGMRSTFEARGYTVWDTKSPMFLQEGPHGTAILYIPSVFISYNGEALDEKTVLLRSSEILAKTTIELLDLLGPVNEGTTVSYHSHHVHTTLGTEQEYFLIDRGLYSLRPDLKITGRTLFGGLPPRHQQLEDHYFGKIPTRILAAMSECEMELYKLGVPVKTRHNEVAPAQFELAPIFEEAMIAVDHNLLTMDVLHRVAHRHKLKVLFHEKPFKGVNGSGKHCNWSMSTDTGENLLEPTAHPETNYRFLLFLVAILKALADHGGLLRAGIASASNEHRLGAHEAPPGIISAFLGDHLNDVLDSIEQDRPLKKFGSSEFHSVRVGGTVLDLKVATLPNIARDLTDRNRTSPFAFTGNKFEFRAVGSKQSVSFPMTLLNTAVASSLQYINADLKKQMGDKKFASTEDKITIIKKYIKETKKVRFEGDNYSEAWAEEAKKRGLPNISNCPDAFAQLQDKHNSDMLNKLGVFSPGELNSRYHILMEKYAKDIQIEAETLRTMVVQHILPSTFAYRRELAETASLLKSAGSDSSPEANALNALSPIVVGLQKAAAKLEEAVDEFINIEDIDELGKAAHDSLFVRMEETRSYADKLERLVADKHWPFPKYAELFLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDS6</accession>
    <name>A0A8H7UDS6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDS6"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1017" mass="112733" checksum="8212BA4246472BD0" modified="2022-01-19" version="1">MAKGSNPLTSKSNSSIGSQGSNKKVSTGWRNIAIKPGGALKSPKAKASNNIAQNPQQAKQTTTVAPKSESPASAVVTPPPAEEKPKPRELSFVLSALRDSINEQEEKERQKNLGKVAEEDENLDDDDDDGELPAFPTPPIPSLDESQFVIQEQSQPETKAEEAPENAKADKVEDNKADDKVAETPQAEPEVKSEEKADATTEAVASDDKKEPATASTAINDDEASKAEVNDKKDIVEPMPTQATQADAPESVKELENEPVVTSEPQAVAAIVSEPSSPVPDAINEETPKIDTAEALIDVPAPKLDHAPTTHASVIPASSADAFGGVMAGVESGKDHSLEEHNMAEYMSPPTPGIEPSHADQQFRREIEDATFEQEGSSSTTFALKPIDLKAIRPNFLNPREQEDYDADMHTAMSLFFNNKFMKAKALFETKANDDPLYALGLGAMAFIKGMENWNMFLGTLETFSETDMKIAMDTLNQAARFANAQIEAAQAKKPFKDTVSHYFSNLMGSNTTGMPTNTPPLSKEEKNTNSSFISNGALRAHVIKAECCLLNAILQLCSENLVGYLKVGLNLRAAYNSYSLVWQEYKKMGQCFNDHMDRDTISAIQFGIGSVHLLLSSLPPKILKVVAAFGWRADKHLGFALLKLCLEGRRIRSPLASMMLLAYYSILTSFAPQILAAEFTQPAIECLLDAQQNYPNSAFFLYFAGRVSRLAKNLPLSTQSFVYASEISIGEWAEVEVRHLTDYESGFNYAMELDWATAGEIFEQLYEENYWSPAFCKYFSATCMDLLGHRTEAILAFADVSKLGNKKNTSAELYVLRKVEQFQLSGYQDMDFSIPALEILLIWNCFPHMSSENLEQCLSAVDSALSRIYEREKQEYDLRMRELAPNQTPPNYFDQRGVLLLVKSSLQNALGKYRESIVHLNWIIDHREMIKEDLWVVPYAYWEAGVTTWGLGQNAKSRKLWETGLSYSKFEFEYRLAVRINLALNLCDEMGIVHVERPKPSRGLSTGGRKRMSIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UE37</accession>
    <name>A0A8H7UE37_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MABP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UE37"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023341">
        <property type="entry name" value="MABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF0">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51498">
        <property type="entry name" value="MABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034819991" description="MABP domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="MABP" evidence="2">
        <location>
            <begin position="123"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="654" mass="73378" checksum="36D964194FBE23AC" modified="2022-01-19" version="1">MVHKPHLWFCLLLLSITTSHAYVTHLELTSCKQGSACSPVPGFKMLPVNVNQDTDLDSVFLHLRNDHTSPPITDLMLVQAPQPTEIDGWTYMNINLHQNSNQPKKEDSNAIWLYYTRNTTISNRPITSIIIKQGKNQDGGVGYRRLAMDLNTKVGGEHLYYHQDGSAEPITAISAKSCFSDDCYIEGWERVPKDVNEGVIIGFRVYLFFKRERGNSPVTDMVVVLDDQTPPEGYIKVDVDLNSGTVRGASIFLYYKIESNLTEDDLKTAVQQMAVAYGDSLGTPYGWNKINVDLNSQGHDSSDGFGQPTFLFFRRGYEVPEKVPPLTFKADGTFKILQLADLHFSNNKGKCRDVPPNSSCEGDSTTVASIEKLLKSERPDLVVFTGDNIDGIGGVNDARTATLKYSQPVIEQRIPWAMIFGNHDDENDLSREELFEVVRNLPYSISEEGPFEISGVGNYVLKIWTNGTDAKLTEKMHAFTVYLFDSHAYANPEKTVYGEIKQDQLEWYRNVSQSFKTGQADTPNAIAFFHIPMPEYNNLDRDGHQQPILGDKRETVSSGKDTSYSILSTFREGGDIRATGCGHDHVNDYCMNAEGIALCYAGGMGVNGYGAGHLGWPRRSRVWLIEDFGSTIRTWKRLDDKMLTMIHYQTLTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEG3</accession>
    <name>A0A8H7UEG3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEG3"/>
    <dbReference type="OrthoDB" id="2425131at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF161">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2176918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="45814" checksum="89802D05F316405D" modified="2022-01-19" version="1">MSSATVRHFRHHARSCAQRPIVHQRLHTRHYAQRSAAKSRRNTTHTPGGVFEPFLKPTDGASASKITQDPTPLARDLSVKDVLPKDELLKILMTNSNLTMPIEKQKAAVQAVLETLQQVQPSKAAFPKLLELSENKSADLTALGNVILRANSQASQIALVLYECAMEAGDDTAAFSYANMLYRGYGGIEKDIDRGIQILTDLARKGHPYAQMNLAAIVMRTKKDGGKTAVQLYELAGRGGIDSAWAELGRMYRAGLGVAQDHQKAMDYFRKGAQSGNAQCNFMLGVYYSAPQDGSPVDQAAAFRHFQKAAIKGMPEAQYNVGLRYFSGNGVEQNFVNAAEFYLMAAAQGFPLAESNLARMYYEGRGVKPSLEKAEKLWRKLADRGGPIGKDAEKCLEQYINNQQSRSSDKTKCTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFB0</accession>
    <name>A0A8H7UFB0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Maltose/galactoside acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_008470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFB0"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03357">
        <property type="entry name" value="LbH_MAT_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000008">
        <property type="entry name" value="Maltose O-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF23">
        <property type="entry name" value="ACETYLTRANSFERASE C18B11.09C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Maltose/galactoside acetyltransferase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2180890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="193" mass="20601" checksum="DFE7B2AB32357D48" modified="2022-01-19" version="1">MKTEREKMIAGEPYNPKDPELVSGMKAVRDKITTFNHSAHGDSATRKKMLDDIFGTCGPDCYIEPPLSVDYGFNIHLGRNVYANFNCVFLDCAPITIGDDTMFGPNVQVYTASHPLDAVQRCSGVEFAKPITIGKMCWIGGGAILCPGITIGDRAVVAAGAVVTKDVPADVLVGGNPAKLIKHIPPPTNQAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFK8</accession>
    <name>A0A8H7UFK8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFK8"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="2">
        <location>
            <begin position="54"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="1">
        <location>
            <begin position="124"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2179827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="26619" checksum="4F6A698DEA70132E" modified="2022-01-19" version="1">MSLFSIQSTKTVAMSQARPTPSKMRAWRLNRLGPFDETLRLVRDFEVPSEPLRAGQILVRITSAGLNPIDYKTPGMDLSGAAVSVGPDVSDIKAGDKVLARIDLTKDTHGALSDKVYNKGGSGGVGSFGIQIAKILSCHVTKSCSTAKSSLCTELGADEVIDYRTTVVVAHLKQGGPSYDVIVDNVGNLTSKLFSACSDILVPEGKFVCVAVTPNLSTLKTIVKGKLLPRFLGSSACRLSCTLLETIMRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFL1</accession>
    <name>A0A8H7UFL1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase eIF4A</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Eukaryotic initiation factor 4A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">INT43_003326</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFL1"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18046">
        <property type="entry name" value="DEADc_EIF4AII_EIF4AI_DDX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000089">
        <property type="entry name" value="Eukaryotic initiation factor 4A-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044728">
        <property type="entry name" value="EIF4A_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="52"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="233"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG2178073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="394" mass="44811" checksum="541CEF25A0B46DD3" modified="2022-01-19" version="1" fragment="single">NEELKEVLDTEIESNWEEVVDNFDNMNLKTELLRGIYAYGFERPSTIQQRAIMPVIKGHDVIAQAQSGTGKTATFSISILQRIDVTLKATQALILAPTRELALQIQKVVLALGDFMGAECHACVGGTNVREDMEKLRSGCHVVVGTPGRVFDMINRGAFKTDNMKMFVLDEADEMLSRGFREQIYDVFQLLPTETQVVLLSATMPPDVLEVTTKFMREPVRILVKRDELTLEGIKQFYVAVEKEEWKLDTLSDLYETVTITQAVIFCNTRRKVDWLTDKLHAREFTVSAMHGDMSQEQREVIMKEFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPANRENYLHRIGRGGRFGRKGVAINFVTSEDVRMLRDIESFYNTQIEEMPMNVADLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFR8</accession>
    <name>A0A8H7UFR8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFR8"/>
    <dbReference type="OrthoDB" id="10488745at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2178253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="143" mass="15652" checksum="0A3FA87D177672F5" modified="2022-01-19" version="1">MQRNGVPQAAVLQQYPPPPTGAPGQYQYPPPPTPQGNNYYQPPPAAGDGYYPPPSSPPPQNQQDYSSPPPAYNNNKADSNLQANHNNDYNSSVPYNYGEQSSQNYPPPPTQAQTNPDHQGISMPDPSHYQNNHAQQKPNFGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UG77</accession>
    <name>A0A8H7UG77_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003327</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UG77"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="276"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="363"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2178074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="549" mass="63675" checksum="2BA5E671EE0C5EEB" modified="2022-01-19" version="1">MTSKVKKADSVEASDKLVSKFLHEDIPQPLRKRSRLTWRSTPIPQCVKVGIILTNLRVEKPISKEDDQDIVEDFKLSLNDSSEAIETIRKESVFSEEVTESEMEVIQKRVAFQQRQFAQYERRERMRKSAKIRAMFDYICDEEIDEMLLDCEQDEDEVIVRLTKQDYLQSIRRIIASKYADEVETQGNVMNDEQKAAYQQLLKKRSETLKKTSTDQAKKQYRMGGRLGLDDALKQARENKMDLEKAFEGWSQARIRAYQMIDQNPNSYYYRFNAPGEEQRKGQWTEEEKKVFYKRLEEVGANGQWGIFSMSIPGRVGYQCSNFYRLLVETKQIIDPNYVLDEKGKAHYLFDKKNSNGEVEKTFRTHSKHGGGAAESPRPRATRTRAAPSTAEKKTKKRKRRGNRWDSDDEDESDDFEDYNDNSGTYTMSNWGTTKRTRTRASTRTTSDLGAGSEGSGDMDQDEDDEEEDELDTNPLPGFVDPITLDEVTKPAISKYGHVMGYDSWVRCLTNWEGKRNICPLTKKPLTKRDLVILDHENIEEYRSQIVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UG89</accession>
    <name>A0A8H7UG89_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_006850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UG89"/>
    <dbReference type="OrthoDB" id="10248551at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000002">
        <property type="entry name" value="40S ribosomal protein S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="4">
        <location>
            <begin position="34"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2181925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="130" mass="14775" checksum="F5EEE2A845266864" modified="2022-01-19" version="1" fragment="single">FPNVCIVFFIQAKPTTQQKPGFEESADAKIHRIRITLTSRNVKNLEKVCADLIQRSKDKQLKVKGPVRLPTKVLRITTRKSPCGNGSETWDRFEMRIHKRLIDLHSPSEIVKQITSISIEPGVEVEVTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UG95</accession>
    <name>A0A8H7UG95_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 62 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UG95"/>
    <dbReference type="OrthoDB" id="2405412at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF6">
        <property type="entry name" value="MANNAN POLYMERASE COMPLEXES SUBUNIT MNN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="44184" checksum="99C4B40BFAFF4F31" modified="2022-01-19" version="1">MKLSTSNVGNLRSNKRFLVVSLITAFCLLFTVFSMGPSLSTCHGTIRTVNSAQALSSDGAKQMTFSNLNHLTATASARDNKEHVLILTPLKNAVPYLERYFELVDRLSYPKHLISLAFLVSDTTDETVSELQRHARELQTRWHDRYHSIRIFEKDFKFELTEEERHKYELQPKRRSFMARSRNYLLTAALTEEISWVLWLDVDVVEYPSTILEDLQSVDEDVVVPNCLLQREDGAFWGYDKNNWQETPASLEIQKDLAPDFVLLEGKKIAKVLHISSFFVLHHICADSDKLTPLPHLFTGYYEFPTYRNLMVDMPTHNDKLDKVPLDGVGATFTLVKAQVHREGANFPSYPFQHQVETEGFAKMAKAMGFTVYGLPSYIINHITNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGQ6</accession>
    <name>A0A8H7UGQ6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein mL67</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_008624</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL67 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGQ6"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024629">
        <property type="entry name" value="Ribosomal_mL67"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28184:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28184">
        <property type="entry name" value="MITOCHONDRIAL HOMOLOGOUS RECOMBINATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12829">
        <property type="entry name" value="Mhr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2181042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="177" mass="20249" checksum="E510923916EC254C" modified="2022-01-19" version="1">MSSSINLFRHIQTSQVIVSTKKAMKPNAHHQLDAAIQPVRLRKDLWRPMVTIDGFKDEKTAQAVTDALLQRSEIRQLETKYSDEHLKLAKRYRKPIEQDIVEHSLVSLREALETVVPRHYSEGSPKLTALWEQQKFADIAGAGAENKWPEFVQHGKLELQRNRFVSQIAKSNQAASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHS7</accession>
    <name>A0A8H7UHS7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3 8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_006581</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3 8"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHS7"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="10">
        <location>
            <begin position="9"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="8">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2183575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="362" mass="41127" checksum="0583BE7B30D7F517" modified="2022-01-19" version="1" fragment="single">MEAQTKSSEWLETDISPGSLTELCKILGTKGVQVEELMSADMETLDIMSPVFGFTFLVHYTPNKYHKDDMVVVGGDIYFANQLVNNACSTQAILSILLNCEDVLDIGDDLHAFRESTKDYSPLVSTSVIAERDLISEDSSKTSEIEDDAMFHYVSYVPVSGYIWELDGLKRGPGRIAPLADKSWLDVAGPELQRKMELYSKSRINFTLLAVIKSRVLVYEDQLQAKKRLKRAIESKLDALDPEWRSKCNYSQWEEEFHFTIAEIRKQYHGESSAQPAREIIEDLAVQGASPDSPPSEGWTMPSQTPATLRTREEHVFEENMTLVANSSDPRLMMDMWLQIQEDCVRLHESIAQEEEKISNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UI03</accession>
    <name>A0A8H7UI03_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UI03"/>
    <dbReference type="OrthoDB" id="332390at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013136">
        <property type="entry name" value="WSTF_Acf1_Cbp146"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075:SF6">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10537">
        <property type="entry name" value="WAC_Acf1_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51136">
        <property type="entry name" value="WAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAC" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2182437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="86" mass="10445" checksum="A1CB0C971ADCC67D" modified="2022-01-19" version="1" fragment="single">MLYRQPIWQCETTGRSNLTYVQALESERKAKERVDDRFPEQLKACVLKRLQFRTERLETVVEDIYNYYVDRYLPGEVIHCRWDDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UI50</accession>
    <name>A0A8H7UI50_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UI50"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2182572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="99" mass="10779" checksum="EF25818F36A774B0" modified="2022-01-19" version="1">MSVFQFDDDDHPALRDHAFDDELASGPGNTIAHLRLTDSNPPSGYNSDADEAKPSQDKDKEFEVKLDETFVSSKAQEAKGNKKVGPEDFQALKVIGKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJ09</accession>
    <name>A0A8H7UJ09_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_000838</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJ09"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00014">
        <property type="entry name" value="CH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06627">
        <property type="entry name" value="STKc_Cdc7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="527"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="112"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="350"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="434"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="941"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="999"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1044"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="452"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="944"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="999"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="556"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2184925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1106" mass="123514" checksum="09E8F9B9359BA35F" modified="2022-01-19" version="1">MQDTTVNNHNSDLNLDSTWEAQQWIEKVLGYNLPTNDLRYDLQDGVLLCLVLNKVRPGTILKIGYKDHPYVKLGLKSSELFQPDDLFEGKNMKAVLNTILVLRRKLSAQPLPVVNRKSHSSTSKASFSKSTPFELYEDLPPPSQQTTSTSSDMRRRSALNYIPSTEITSTKSIGTYNSKNTTKSKYSHSKHPSDLSYVMDPLTHDIQPHRRKSRAEIVTEPNTRAKYEKQDRSQYRHVKDILFDMQGPTDHYTSTEANTQQPKNDLLNFPSNIIKKANELTDAAQTFLKMGDIDEEETAASNAAKSPSDSGYGTNERRRLSKQPSIPASFMSVINGSSNSIAAASTVTFSSNSHNNHDQSHGRETKHTSSISSKHGILNNLPFPKKNSTRQKIPFHTRYQEWSEQNKEKFNSSRIHNTSDLLFDHDASPTSLWHDLSNTSHEQYDNSETLESQQSPNPFPSMSSPMPTLKEPVKSLDVFKGGSVGKTKANRQSIVYSMKTSDTKLMADITKERLSLFDDEGELVAQYQLGNCIGKGQYGSVYKALNLGTGQMVAVKRIALENANAKEIDELMKEVDLLKSLSHPNVVQYEGFSFSENHLNIILEYVENGSLRNTLQAFGAFPERLVASYCVRILQGLSYLHQNEVVHCDLKAANILTTKAGNVKLTDFGVSLNLKMNNVSDGVVAGTPNWMAPEIIELKGACFQSDIWSLGCTIIELCTAKPPYADLIAMATLFRIVEDDCPPLPDNISEDLRDFLRQCFRKIAADRPSPEELLNHKWIHKNVFSLSTELSTDISQSPRHAHMKRHTTDPDVLLPMDASFSSTADINPPFAYKQSNYSEGNLPASIPIQRRSLDLHVRQGDSPLGSQPPNTRSVGFLVSKGTSGVTSRLFSRASKRFSREIEVADLHRFVKTSFSKYCSLVCHERCKQDMPPCSIYVATRPSMDEQSPSRDQSPNLDDEVDTKPSVNGRPRPFSEPPKPTRRRKSAATILEEATNVESLIAQSANSPPTPSKSISSNLRQRTRKISKAISSVSTNNLHQHFAELGRPNRNRDTHSFSLGDADSLYSPNAINASSNDLRSYSSSDLGHENVPAAKLRRHDKDECIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJU0</accession>
    <name>A0A8H7UJU0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">OPA3-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_007338</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJU0"/>
    <dbReference type="OrthoDB" id="2129069at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034303650" description="OPA3-like protein" evidence="4">
        <location>
            <begin position="16"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="99"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2182408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20740" checksum="DDA57585BE787568" modified="2022-01-19" version="1">MSTLKLGALLVRTLAKPVATSIKTQAKQHAVFREFCISIAQLSHKLEMNMKMKFLGYRKEVIRPLNDTKAIEAGANFLSESFIFGVAATIILAENWRSRVSAKNRRNLVDESLEKLETETNGLRETIQSMQSGQAALQSRMDETTQENEQLKKMLDEILSVSLGLRKHTGYEQPTVIQLPGFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJX0</accession>
    <name>A0A8H7UJX0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucosamine-6-phosphate isomerase</fullName>
            <ecNumber evidence="6">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_002323</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="6"/>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJX0"/>
    <dbReference type="OrthoDB" id="7663298at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006043">
        <property type="term" value="P:glucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000002">
        <property type="entry name" value="Glucosamine-6-phosphate deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280:SF5">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2185885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="330" mass="36847" checksum="CD15C153E1594446" modified="2022-01-19" version="1">MRLIIRQDYDEVSSYVAHYVKERVNQFQPTAERPFVLGLPTGSSPIGVYAKLVELHRAGQLSFKHVITFNMDEYVGLPRNHPESYHSFMWNHLFKHVDVNIKNVHILDGNAADLDEECRRFEATIARVGGIELCLGGIGPDGHIAFNEPGSSLTSRTRVKTLAYETIIANARFFEGDVTKVPKLALTVGVATVMDAREVLVVITGAHKSIALAKCIEEGVNHIWTVSAIQMHPKGLIVCDEDATLELHVKTVKYFKSIEHVHQSLIGPHNLGLQGNLLRSMKDTDENVTKRRKLFLGTVLNTDEEPPVSSDDKYVAKKNGNAGWKRKMDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKL6</accession>
    <name>A0A8H7UKL6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_007264</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKL6"/>
    <dbReference type="OrthoDB" id="2150324at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF149">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="600"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="626"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="656"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="23"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="209"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="10">
        <location>
            <begin position="392"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1015"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1016"/>
            <end position="1025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2182334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1090" mass="123166" checksum="4D9C2DB947F301D9" modified="2022-01-19" version="1">MSSVVSFDSQRSQDAALDVKGMATQLGINLAISVGVLLGFQLLRPKNTLIYAPRAKFGTNEITKPPQVGNGLFDWIKPVLHTKDDVLLQKIGFDAFIFLRILRILRHILYTMTFVGVCGLIPLNIIATSRTGVWPPGASIDFLSISTINNVNGKAPSNANYTWYWAHVAVTWIFTLAIFFFFYRGYVIYARIRQQYFTSPDYVASVHSKSILILNVPKECVNDSTLKRWAESIGIRSRIAEASIGHNSEKLSKLVVEHEQAVKQLEITLSSYLKDGKHVGKNRPTMNVGGFLGCGGRKVDAIDYYTKESSDLEKEIKTLRAHLGDQKASNYGWLAFDKISVAHSVARQLSDGKHFEAKYEKELDKPKVSIAPAADDVIWGNLGMNLAVRRTKRIIGMALYWALVFLWIIPITALSATSNIKNFLRLVDPSSTFATNFPILVGLIEQWFTPIVFSLFFTLFPYLLRYLSQQQGYISQTSLDRQVLSKLYAFFIINNLCVFSLSNMLIAIYGQIMDIIVHQGSGAHLAETVSQNVNQLAMNLTSVSNFWIATETTKALGITMDLAQLVPLVTITLRKFVTRPSPRQLQEIAKPSEFGYPQNYNLLLFFFTVGLVFSVMSPLIIPFTLAYFVIATMTFRYLLLYVYETKIETGGRMWRVVFNRVLASTILFQIVMIGVLNLKGGHLQSYTLIPLPFLTLLYKYLCSRQFDKKSDMYIPRRGEEEAILAKVQPTGRNSHLSSFAEPSRFTKLSTPTVHEDVKHLLPNVYHGKVHDSIKTVRDRKTHQTHTNHNTILESGDGVNIQFNSMNNEQIASEPLESAYGGVYGDRNSEDVDSESRLRLIKTNSGSQYDAQSSHMAYPADAVVHNSVNYGHMGQLPGGFIRSMPDPRSYSAETQYYTPEPEKMHVWPGSNNSYRESYELYNMPPNVPAHDNRYRDSAKELVEDDPVDFPDESTWDEKTEDVIYNDPDTMSFESSNLDLDYIQINRRNTEPCLSMANQTIDEDRRNTMPNIKIKSAVKSDDTKEQPLRSSTMPLSGRYPSNDHNVPRSHTLPPHMQTAVQQSRTGGNRWSTMTETGTGSRYDRVHYGGGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UM22</accession>
    <name>A0A8H7UM22_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_006785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UM22"/>
    <dbReference type="OrthoDB" id="21573at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="entry name" value="Translation initiation factor 3 (IF-3), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="entry name" value="Translation initiation factor 3 (IF-3), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938:SF0">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="Translation initiation factor IF3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="Translation initiation factor IF3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor 3 N-terminal" evidence="6">
        <location>
            <begin position="71"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Translation initiation factor 3 C-terminal" evidence="5">
        <location>
            <begin position="148"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2183774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26553" checksum="5E48A5EC9339788F" modified="2022-01-19" version="1">MLGRLLAQSHRRVLVAAVPRQSLSFLQTRTVKRQVRDPLGAVLAAAATESPQRPTTPSPPKQKKLGRQRRDEEITARFITLVDAEGTVHRDVRIRDALSKLDRQSQFLIEVDPLAEPHPVCRITPKKSVFEKNKAAKRQNTSRPEAVLKEVTFGWNVSPHDMGHKLQKAEQFLSKGNKVRIEVVAKKGQQRLPRDAQDEVVEKIVAQLKPHSKAMKNPSFVQNSTCIIVFEGKTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UM43</accession>
    <name>A0A8H7UM43_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_000721</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2235682at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF41">
        <property type="entry name" value="CHITIN SYNTHASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1014"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1050"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1079"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="9">
        <location>
            <begin position="1526"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="856"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1333"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1448"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="874"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1333"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1344"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1503"/>
            <end position="1517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2184808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1586" mass="179034" checksum="3275A307FD155ECC" modified="2022-01-19" version="1">MSQWNLNSNSKDVDKNGAVRANSQPTYRSTSPNESSQATSAERSPVLISNPFASEADYQIDTPISEHNVLASSPTSPIAGSSTPHGRNILSPSTLQRGPVEYLAESTTPPPAGYFHSNLPHRRRVHTWRDSMSSTSSNLTHHRTESNEKMLSTNSTFISDQRSLGFSEPFARHETGRNGYGQVTFKSTFEEGEQEKPARKSRASYYSLSNLTVSGRRTSIPRFLWASFAFLCTFFVPDFILKHVGRMKSNIARQCWREKMAIVYIFIFFSAFIAFWLEYITSLFCDPPDYFPYRTLNVANSKWAEVNGKAVNMSKWTSESSMAAEVSKYPGYDLSPMFPTFTLLAREQDNSTYSDPDIQKCIGDLNMTAAADRWLIYRISNDTGYSEQNQQLTSCPLPTSNGSVTGAPCYYHDSDLQELQKGIKGDITYTRGYIYNNCSSLPNGDNPGSGYVILNGNVYDVTDYLVATSDLMNFSSEITTRKLVQERMFFPLNLTMLMLLNLGEDITPYYYGNVTENADLYLACMDRLFYKGILEDYIDTGCAKINPALWATMGCILLLFLFKMNLSNLSRLPFMRRLLFSSTENDSYMINPSSAPYTMLLVPCYAEVTDVLKQTIESMAITQYADSRKMFMFVCDGPVSNASSNRETYLEILDLLGYSGTEEPLPQAYPSLGEGHKKTNFAKVYSGFYETGRNRVPYLLVVKVGNPRERDDLRRGNRGKRDSMVMAFAFLERCMDLASNRITPLDYQLFNQCYNLLGIDPRMFKYMLVIDADTQVKGTVLQKLVSRLEKDERLIAISGDVRPANPEENVTTMLQIFPLYMRFFSGLAYEACLGSMITINGGFVMYRLWQDKPKDSVTVPNRSYSSPVPPSRPMDPKLSDEVPRNDMHLSSDTNLDGYDKRTTILTGAESNFSLSTPVDAMACCIHPTVLREFATPPADTLHMRSVLLLGEEQYLSIVLLKSHPRHRLGFEPDAIGYTTVPKTLCNLQAQQTRLLRTNFHNNFEMLKVASQIGISYWILAFTKVLDTIVSPVMMVYLYSVFIRFFIGYGLAYEVIAICFLGLVGLHIFYFFLRRQFKYVLWFLLYCLAAVPLFNIWFPVVALWCSNYADRWYDIWKTKGAPKSERLHGIIDTEHEQKESETRDEGTLMMNDTTLGDRGGDWQIPRMRLVEFEAAEERRQSAGVMFEDFDAELVDSEYNGFAGQSSPRMSVSSLSSKRYNSYNGRPAYGDELISTPPMAQIRDGIHSVRTGGSSRKYEYGSAKMKKQAKQPHLRDIFDDLQLLPPSNHRNNDSLMSPDESSLDPFASSMDNPFDDVYTSRNSPFGDNMLTLSTGRPVSRHQPTQSQSSYLSFSSRSTNDPHHAAQNVYADTSTIPSSINSSGFASAPRHNRFVARPKDIIGDYSKSMDDLALNDRNSIKSNISLAESYVSSNLSLDPEESMATMYSVPRSALAQHRRQASEPNKVASNEEDESLGRRAARHNRLGIRIPTNGDPEADIKRSESPAPSTLPIITSTSKASHSDIEFREAIQREIASYLQHADLNKVTRAKVKQHLSSKFGKQVDECQDLQTFVHDSIEQATLDRMTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCL8</accession>
    <name>A0A8H7PCL8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_009093</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCL8"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04197">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000066">
        <property type="entry name" value="Translation initiation factor eIF-2B subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035543">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="10">
        <location>
            <begin position="542"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="427"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2171432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="711" mass="79986" checksum="56DB27672F2002BD" modified="2022-01-19" version="1">MPPKSKLKQSHNETEAEQPLQAVVLADSYNSRFMPLTYEKPRCLLPVCNVPLIEYTLEFLAISGVQEVFVIATMHAEQIKAHIDSSKWSRKNDSTLQVEVIHASECLSVGDALRELDARQLISTDFILVGGDVVSNMTLDKALEEHRSRKRNDGKHTDKNAIMTMVLREGSSHHPSRARGEESIFVIDPTTSECVHFEPLETFPRTKRVDLNTEIFERHTEIECRNDLIDPLIDICSMEVPALFTENFDWQSLRSDFVRGVLTSDILGKTIYTHISNESYAARIQNSQQYDSVSNDILKRWTFPIVPETNLQETDLYEYSRGNIYKGSRVILSKSCIVEDNVQIGSGTVVGENTRIINSVIGKNCKIGNDVNIEGAYLWDNVVIGDGTNVKRSIIANDAIILDDTILSEGCIVSFNVTLGPNIKLPRYTRVGSQPQPKDDFFDDDENSDDDDQDDSARPDINLGEQGAGYIWIDKGDNDEDSDPRNMKIASLAFDLQDLNVGKDHGDGSDSASEIGDISDSDSDMGSTSEMWHPEQSQILAARKVEEFKRELEQSISRAFAEDHTVELAALEITGLRMSANGSYDDVREVVVPAILNQVDMSKPLPSIKAVMQKWASLIEKVTHGKDDQVHVLYILQMYCADHEQMQKLFIPSIRLLYEDDVVEEDAIFKWYNSDRSKQLGSPATSLREKATAMIKWLEEAEEEDSDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCV3</accession>
    <name>A0A8H7PCV3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Agmatinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_008239</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCV3"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034537243" description="Agmatinase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2171513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="42213" checksum="0C93A2D21C793706" modified="2022-01-19" version="1">MLYSPLATVATSVLLVSQALAHQAVYHQESGSPDPFASNSKRPVLSKDSYVPSFSGISTFAHLPYVQCWEENVPDDYDIAVMGVPYDIGVTFRTGARFGPSSIREGSKRTKGWNSEIGINPFKSWAKLVDCGDIPFTPFDSLQAIEQIEQYTKYVLNRPMVPGQLEPKIPQLITLGGDHTVLLPVLRAMAEAHGRPINVIHFDSHLDTWSPEAYGIKPPSVFNHGNPLYHAAKEGLIANGTSMHVGIRSSLYESDDFEKDEALGFRIIKANDIFDIGVDGIIARMHEFLGPKEDAMVYLSIDIDVIDPSAAPGTGTLESGGFMVREMRRIIRSLRDYHLVGADVVEVCPPYDNPAQITSITAADLLYEIISMMVKKEADNRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFP3</accession>
    <name>A0A8H7PFP3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_000175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFP3"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000059">
        <property type="entry name" value="N-ethylmaleimide reductase, FMN-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF129">
        <property type="entry name" value="FLAVIN OXIDOREDUCTASE HXNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2172825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="376" mass="41398" checksum="3BBD1C6EDF5501C5" modified="2022-01-19" version="1">MSSKGLFQPIRIGNHELKHRVVLAPLTRLRADPETHVPNEKHVQYYGQRAGNGGGLLITEATNISPMAGNYPGAPGIWSKEQIEGWKKVTKAVHDRGSTIFVQLWHVGRATHAVWLPNNAQPVSASAIAINGSDTFGIAHEVPRALEINEISDLINDYAKAAKNAIEAGFDGVEIHGANGYIIDQFINSNSNQRTDRYGGSIENRTRLALEVVDAVVKTVGADKTAIRLSPFTHFQDVDDATPNDTWGYLVQQLQNNHPDLAYLHMIEPRFTFEDSAGASEHNLDHFRNIWKSVFINAGGFGHDLAGAIEHAEKTGDLIAFGRYYIANPDLPYRLQQQLPLNAYNRATFYGAGPEGYTDYPTYEETQIAPVTAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFU7</accession>
    <name>A0A8H7PFU7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_004551</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFU7"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF127">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="17"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="136"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="643"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2173177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="720" mass="79556" checksum="10C0CC44E67DA380" modified="2022-01-19" version="1" fragment="single">TTVDSVHAITLSFAMTAITKVLIANRGEIACRVITTCHRMGIATVAVFSDSDANGRFVKMADQACHLGGSLASESYLRGDKIIEVAKLTGANAIHPGYGFLSENAEFAEKVTQAGIIFIGPTPESIRILGDKISAKRYLAEHAPKVPVIPGYNGDDQSVETLKKAALGIEFPVLLKASAGGGGKGMRTVYKAENLQSEIEAAKGESLRAFGSEQLLIEKYFTSVRHVEVQIFGDQYGNIYHINERDCSIQRRHQKIVEETPCPQMTEELRYSMTAAALEIGRKLAYVGAGTVEFILDAKTNKFYFLEVNTRLQVEHGITEAISGLDLVELQILVAQGENLRKVPGINQLQFQGHAIECRICAEDPGNDFAPVTGKILKWRQIDHARQLPGVRYDTGFEDGSEITIYYDSMIAKLIVHAPTRKQAITTMALVLSQTVILGIVTNQKFLLNIMKNQRFQSGVYDTGFIGLEIDNLVPALTNVEEDRLALVGFMFDWAMRNAQRSALRNIPGGWRNNSRTKFPQKLIVEDQDVLELEYEHQLQGSNQHKFVFGVSRGEEKQESNREAILQSVSLDQGQLQAPGQHMVTGVLTCTIGKVLRACQHGLREQFFVADSPSGINDRTMYVHTASYGSQVKVVKQDRLKSANQEDDSDNVSPYTSPMPCRILKVLAPTGTKVKKNDPILTVESMKTEVKLLSRHDGLVTIKVEEGQMVDARVVLCLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFW1</accession>
    <name>A0A8H7PFW1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFW1"/>
    <dbReference type="OrthoDB" id="2104804at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022127">
        <property type="entry name" value="STIMATE/YPL162C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735:SF1">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12400">
        <property type="entry name" value="STIMATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="740"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="783"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="814"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="869"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="909"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="946"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="962"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2173130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="971" mass="112172" checksum="8473B0172CCBB936" modified="2022-01-19" version="1">MTIKRAPSLLPTSATATWQRWGRTLTYQKLNEKYHTNVPRIPFRRRSWAFVMSFAIITLCLFGYGVQYLRLTSMEKSRQAWLFARFPELQGVWKDVAKDESRYQEAIMLRWDNRDIYSCDNYHLSYSTLNQIINSEWNLDGSTHITHQAVRSPHLIVPPFDPSIPVTLKPNQKYCVRVVVPAQLFQFPNINAYNPIDGSPWDSIMMTAVRQSAANTTVPIKLKLWNGHAKLYEANEHNAGRSAHDVPLHEFVNRSGLHVYEAEIALVDEGNYALETRLEYTQGLWNFERETIISYQPEMVKPPSANMTLRVLGREMDHFDLPLCTRGDHPGRWLNLKDYAPERRNMIEPSAVDFQGNFWAPYNCRYRHIPYQDFTQCLVKKYPLIHWFGDSNSRRAIKKMVTDGEWCGDYEAIKSNTTLARSCHCEDYHDMTWNSSVFDPWSRASAIKRNPLANVSKEWGTVDVDAQSEVWFYKMDGLTNLNDPAWEESFKDYPPPENMVVHIDGLKVDEIWNTRFGKPLHIVEPPSSEPQAAEEKKEDDTPEIDNHDDNNQDVAKRSVRLDKRWYLTLAPPQVLMVSLGNWDTSWMPYVDYQIAVQKLVNYIKQRYVPYKTAVIYRAPQYYCCRVDTSDWQRRLSTRRMEAYDRYARDMLTQHVGAKVWDVYALGEARSWQDKQASTDCPSNHVSSDLVAVENQILMNSLCNVDDWFADCEKVTDSCSLSTFMPPEGPPPPESDSGCKLLDGFAILIQLLLASTALATLAIKRARERPQRPVKIWVMDGSKQFLGGVVIHSLNLLVSYSRGRPRHGGPSNLCVWYFLNVGVDTTLGVAILWCILHCLQWSLQRLGVTGIRTGDYGTPPSMRRWAKQTVIFIFALAGMKLCVFGILRFFPFFFDFGKWVLRWTRDNYRAQVVFVMLIFPLCMNAFQIWIIDTIVKNKILKIDDEEAQADDERTRLLPDQPAATHNTTSPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PG26</accession>
    <name>A0A8H7PG26_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_004681</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PG26"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="160"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2173307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="598" mass="66250" checksum="8B01B6C363829768" modified="2022-01-19" version="1">MQRAIFRPRTLRLYQPLIAPARLLSTARPINRPKPSRFAIASAITLGSGYLIYSSTRPPAHSEQLQPLSAFTSSTPNSVQAELDDNFNRIAVKSKSTSELLLSLAIYKACATSWLVDVAPHLIAAAEKVGLSAPVYWIIKRTFFQQFCGGESADECAPVMERLSRFGIGSILDLSIEADIDHPGDRDEYTERADAVTQLTKECVRAAAGEGGMAAIKVTAFSSPMMLLNVNKFFERAREEFIAHMDDNGRIRRTDLCNITFKLTSGQAQVDLMPLQETEVDWIDYMQLLSPKNSAAQTVMTAAGVSQDDINDFKSCLVRLEQVCDMAKQGQVKIMVDAEQSYFQRTIDHIAMHLQSKYNQRTDEDDASSPVVLNTYQMYTKDAQSKLAIDAEQARRQGFVFGAKLVRGAYMHSERKRAAELGIPSPICDTLEDTHNSYNGGVIFLLNKIQQHAIETNQPISLKTTPIVFMVASHNRESVKLTIREMDKNGVLPRTGVVTFGQLYGMQDQISYCLGKNGYPIYKYLPYGQIQEVIPYLIRRAQENSAILGGGAVAMERQLMWDETKTRIIGQPTPEVITAAPATDAAAATPAASSESVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PG31</accession>
    <name>A0A8H7PG31_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sec20 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_004696</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PG31"/>
    <dbReference type="OrthoDB" id="77989at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="11">
        <location>
            <begin position="143"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2173322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="786" mass="86751" checksum="5ED4086002D3F428" modified="2022-01-19" version="1">MNSTVEARCQTVDNHYTTCRQSIDRLQRLHGDVAVQQELAALVRDQVRTFAHAIQALRQLADEQDTESARQSVLERYSLGEKQLKSLQANSRKALLESKKRADEQAKRDRELLFSSKAGRNMEQYELKDRKNTSQDQSLLRASNDVTESLKRTSTLMQQELERSAFTTTVLADSSRTMSSTYSEYQNFGSLLTLSKSIITKLETSDWLDRILLGLGFLFFLTVVIYIIKKRTWDVGISWATWLMGKASPKAAKAAQSARQALTHTATQAAAQATSSILESMQTSATVSSSTTTSATVISEVSSTFSSIVEEATSIVEQATSILKDELMDTSEATLTRSAIKPHPLRPYYTPGLVPNYTSITTTNASSSTPSSLGLELPGSNAQQTFTEYARFAGLRFMTTAVLGPFETGKTLLQVQYLPHEDIEVVAPLATATPAAKVENPISDYYSSSEEEDEDDKFFSSNVHLRKANQGSRSNLPRYNSSYTVRSVYDDNARPQHQLAPIEGGILDAIRALINHSTEGWRSLLKGQYTGWLHGMLQLVLQPSVEGSLNDLFDLYDDTIPLIHLERIGPNLATLLASHVLVGVLLSPLEIARTRLIVQSSAPGVRSYSGLMNCLSSMKQNEGGLKGIYLSPNLVPTILYHFITPLVSSTAPLVIDRLFHISASDAPIAYGLAKLLLSTLEVLMTLPVETIRKRIQCQVKFKDGKPFNTCVATRPVRYTGFLDGMYKVMKEEGTSLKRKNHHGQESVEKKSSAWGVQALYKGFGIQCASNVLSSLVHTLNGIEGQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGD6</accession>
    <name>A0A8H7PGD6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGD6"/>
    <dbReference type="OrthoDB" id="2389992at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="205" mass="22983" checksum="FCF3399DD1B8479C" modified="2022-01-19" version="1">MERPPLTDRISFSFATTATQEEPLSTWKQQLGTVWTSIDWRMITRILKCDVAVTVSFILILSNWGWSQIGTGMVLSSIAIEFIHPAGSYGRIWENAAFGVFMSSLATAWSILGTYCAHVVRNPDDPTLTQPSVCVVLYTFLIVGAFVLNYVRVKWEQTNVAGLFSATIMILSLVSAVRDTQWSPRTVVRYQSIVISLLQIVELRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGI2</accession>
    <name>A0A8H7PGI2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL28m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_004649</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGI2"/>
    <dbReference type="OrthoDB" id="361870at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.40:FF:000003">
        <property type="entry name" value="54S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="entry name" value="Ribosomal protein L28/L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_bL28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribosomal_bL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="Ribosomal_bL28/bL31-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribosomal_bL28_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="L28p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2173275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="119" mass="13716" checksum="5AED46EA378FE51B" modified="2022-01-19" version="1">MFSAQPGYALARATFKRAQRGLFGGKHIQFGNNNPFSKKKTRRSWLPNVQSKKLYSELLDSHFDLKVTTSVLRTIDKKGGLDKYLLDTRDKNLFSDKALTMKKDLQQVIRQKTVEKPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGY4</accession>
    <name>A0A8H7PGY4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_005206</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGY4"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="6">
        <location>
            <begin position="334"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="7">
        <location>
            <begin position="410"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="9">
        <location>
            <begin position="665"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="8">
        <location>
            <begin position="760"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="5">
        <location>
            <begin position="885"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="131"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2173786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1019" mass="113431" checksum="2DC561405E88C2BD" modified="2022-01-19" version="1">MSVGNPPPPNNMNPNRPPFRPANSPQPPAQYGGPIPQPRPHVQGQGAAIRPVPNYSGMPRPRPVNAATAPLPQQPGQGRPQYQQAHGPNMMPQQQQQQQLNQNALTAGMQNMNLQPNVAAAAAARQVSFMPSIQSPPVGPLSQQPSHHGRAKRVYPAAPGVTSMAQNGPSPPPNQGAAAPPWPHGIAQQPNQSPVRGSVPQQHMQQPMQQQAQQRPQQQMDPNMIPPSQPRPKVDPDQMPAPVQVREYDQNLHGGKFVGTCDREHIPLSTTDFLAMDQGNCNPRFMRTVTNSIPRNKELADVAALPLGLVVQPLAALSREEDPIQVVDHGPDGPVRCTRCKAYINPWCIFVQGGNRFMCNICGHSSEVPQSYFSNLDVSGRRLDLEQRPELRLGSIEFEVPEAYHSSKQPAPISHIFAIDVSFNAIKSGLTATVCEALRRSLFDIEPHSSLLPDNSRIGIITFDHSVHFYNIHVSMACGPEYQPDCEQAQMMIVGDVADMFVPIQDGMLVNPWDSKDIICELLENIPGMFAQSQRNDSMYTSAVQGGMLGLSVHGGNLHVFQSTMPISGPGALKARDEASLRNTDKEKQLFVPQNDVYKDLAKECVKNSVCVHNYLFPFAYIDVASLSTISSTTGGDTFFYQQFTPADLDRVMYDVTHVLNRYSGFDAVMRIRCTDGLQVMDHYGNFNMTNFTDVELAGIDEDKAIAVSFKHDGKLEAERGVSFQAAILYTTKNGQRRVRIHNLNVPVTEHIADVFRQGDHEATVTFLAKKAMYDELHIPRKEIREKLSELCVKILSAYRANCASSTSPGQLILPEAFKLLPVYTAALLRSKALRGVGQDITSDIRVADMKLIMGQSPRETSIHLYPRIFSLHNTADDFFHGASPKTIRASYERLDPKGAYILDNGDCLYLWLGSKIESSFLQDVFGVADKNEIDIQMANLPSLDNRLSKRLQIFITELRASHPKYLKLRIVRQEMDRIEFEFATNMAEDRNAEVQTYVDYMCVIHRQIQEEVKKTKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGY5</accession>
    <name>A0A8H7PGY5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_005073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGY5"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2173655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="75" mass="8314" checksum="E3DA4B9D13C0659E" modified="2022-01-19" version="1">MDMFSKLFLLVLSKLQTLMKTICVLSAIIITMALGSPISLSHVWQEKRDGKHKLAASVDGEYLQDLPIGVPVEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHN7</accession>
    <name>A0A8H7PHN7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHN7"/>
    <dbReference type="OrthoDB" id="66510at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="463" mass="53781" checksum="AB0EB96A083CFE94" modified="2022-01-19" version="1">MQSAECQKPRKNRRSSIENLPNPSHDALQPNDDESVLFQDFHLEPLDYSDIFGQNITQQRRMETNSLHHPERILIPQDILDTCSALDLSCLYLLDAFVLRYSTLTVDHDLRNCHKMLSELISRHSKSSMHNEILGSIRVQLKSVIKSKDTQALIDHLITIAINLQQVLQQADKAISRKNTWQFTNEDTDEAMMVVRQITDDLKSLRTKDSTLSGDVWDNIDTCLNSIDNLIDTILSDSQLPLYDEACEATKQDDKLPSYYTNADNLDEKTSSDGELYDLDGLFSALDRITISVPRLHDQCFDMNNEQHDVLDASTITATLERLNRGRLNDQRADTPRQDALNQTAHNPKRTSVEYQKQRNAQQKYPEQVFLSMMRRWIQHVLNYGERRRDRSRQKTKAERDSYTLDLITRFDRLREKTRFHNQDAVMMLCYRELDQILSHLDRSKSQFTNQRATFRTAPTTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PI56</accession>
    <name>A0A8H7PI56_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_004246</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PI56"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="44"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2174225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="472" mass="52088" checksum="E7132BC5F0E328D3" modified="2022-01-19" version="1">MALSSSNAHIEDEFNHASRISIEDTKENSTKEYSSLSVAQKYGILAIVATAAFLSTLSANIYFPALGVIQKDLHTTPELINLTVSLYMVFQGLSPSFWAPLADQWGRRPVYLATTTVYLIANIALSLAPNYPAVLVFRMLQAFGSGPVIALGAGCISDIANPTERGIFFGIYTAGPQVSFAFGPVIGGIIAQNLGWRWIFWVLVIFAGVLLIAITFLLRETLRSLVGDGSGYANPTPSQWLKKHVKRDCPGSTTDYSRFLHCPNMLKPLIYAFQPDIGLCLIYNAIAYSIFYAMLASYSGLLETIYELDQLDTGLCYMPTGIGCILGSIVGGKILDRDFRIISKRHNYDVKILTRSSLDIDYPVYAARLRTVWINHTIFSGKKANLTSEIIPSHFDLIWFHAADQSAFSLDLGIPIHLAAVTASIAPGITYLGVQYMFLMLGMILLLSNVVLWVVKRKGPAWRKRRAENTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PI68</accession>
    <name>A0A8H7PI68_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED10</name>
        <name evidence="8" type="ORF">INT43_004211</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PI68"/>
    <dbReference type="OrthoDB" id="337270at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="174"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2174190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="230" mass="26073" checksum="585CBA744FD91876" modified="2022-01-19" version="1">MSEHSPHEEIMAEATEDPSRASSSNAKDAVETHLQELLQTLLDLSIIVYDFQPEGNRLVWNKINDIIAQYQSIDQLKDEISEYIPEEVINYVEQGRNPDIFTRAFIERAAGENQYTNGKIQAVSFRTGYAHSLPFLIKEFRDLLQNELLQSFPDLELPSLNDNEGDSAIDKMIESSNRLPSSNDKGERLADTAFPDQQQSQLDAATNELEKEYSNDNDNDNADSDEVMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIC3</accession>
    <name>A0A8H7PIC3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIC3"/>
    <dbReference type="OrthoDB" id="2203282at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034089752" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="23579" checksum="18884BD2AEB23EB1" modified="2022-01-19" version="1">MARLSLVVFALVALLISFCAAQGGVSKTGKKDGTAIYKATKQPSAGTYKIKAYGTHSYMNFNSHGNIVSPSSSATKWTLKHHSGSKYFSLQIKKGTLPKCVSTRWTTKGKGGGYPDAAVMWQCEVDGYSYHGKRAENGTSILQKRYSKIVTEKQEWAAVPVHGKSNTYKIFSASHLYDMTPRCISHSKISGGTKLQECKVNTRSNSLYWTFEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIT2</accession>
    <name>A0A8H7PIT2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIT2"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2174762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="172" mass="19434" checksum="1F79F79301F2CACC" modified="2022-01-19" version="1">MWLSEEVQLVEEEHLADSCRYCCAICDETFVSVADINIHFQVQHLEYQSGADETIEEQNAETDASTAGQIVKVEEEIEVLLVSEQIKNPFLEQGNPSVRVASRRKSNSEQLLSENLYSTYRPKLTTSDFTRMAGSFEFEVVGHSNLLTALSKMVTIPWLKPALDLDPPSEMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJ19</accession>
    <name>A0A8H7PJ19_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_006036</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJ19"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="516"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="547"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="656"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="684"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="556"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2174974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="737" mass="81108" checksum="4050B2267CB65F39" modified="2022-01-19" version="1" fragment="single">YSKMAANNSIVIDYEQTNYKEEARHHIQKLPVYAKEYARDLFPIFQWIHKYNLTWLVADLIAGITVGIVVVPQAMGYAKIAQLPPQYGLYSSFVGVCIYCFFATSKDITIGPTAVMSLLIGQTITRLTANSSQFTGPEIASALALFGGLISVFIGLVRLGIVVDFIPNPAIAGFMTGSAITISIGQWPNLFGIKGVNTQDSAYLIFGHFFQNLPNTKVDVAFGLIGLLWLYGVRFGTNWLTRRYPKHERALFFINIMRNGILVIFGTLIAYLVNIGKSTSPISILKTVPAGFQAMGVPKVNPTLLSEIASSLPSVVLILILEHVAIAKSFGRINDYRINPNQEIIALGVSNIFGSFFGAYPNTGSFSRTAIKARSGVRTPIAGIFSGCVVVLALYALTPAFYYIPSAVLAAVIIHAVSDLVSGPSFVKQLWRVNPLELFTFVAAVIITFFTSVEYGIYVSVALSIVILLVRIARPRYSVLGRIPINSGDNKNPESQYLYIPENHPSLGNRVESVAPGVLIFRFDEALTYPNSSFFADRIIEQVHQRTRRGKPLAAKKGDRPWNDNSSPKEDELSASLPKLVAVVFDFVTVNNLDSTGIQTLLDVQNAINKYADREVEWHFANINSPSIRNALLAGGFGTSNSVHEREILPVVPASQDGPVRRSAQKQSSDIESHQDFDEAISDHEQKHSIHKEHRFSNDSESLSLPGYPVDRYPLFHWNLEEAVRAASSSALAANNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJ46</accession>
    <name>A0A8H7PJ46_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_005778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJ46"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF8">
        <property type="entry name" value="ACID PHOSPHATASE PHOA (AFU_ORTHOLOGUE AFUA_1G03570)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034334536" evidence="2">
        <location>
            <begin position="21"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2174720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="364" mass="41655" checksum="47EA6D6BFB09227C" modified="2022-01-19" version="1">MKLAGIFASSCALLAAMAQGKPVQSEHGHSHGQTGPNGVKYVKGRQFDRIFQIVFENHDVWPVHADPWFGHFWKQDNHRLLGNYHAITHVSQPNYFNMIAGTDFGDNMYNAVNGNPNAMSNLTLLAGSDMPINFTSSALTVVDVLEEAGVTWRAYAEESRNSSQYQNPHHLYTLDPIHQGCDFDYMPGDPDFQWSEGNHTYTRRHFPFVSFPSITSRKERCANLFNADQFFEDYKKGELPQYIYYVPNLENDMHDSNTTYGSEYIRHTWKEIFDSKYFMENALNILTFDESANFTLTDMNNQIYTVAWGSGVETNSAWDHIDWAYYNHTSLISTVEDNWLGKIGQLGTNDTYANVISVKKPRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PK43</accession>
    <name>A0A8H7PK43_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pseudouridine-5'-phosphate glycosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_001251</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PK43"/>
    <dbReference type="OrthoDB" id="198885at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="Indigoidine synthase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2175604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="29410" checksum="469B154ECA549D17" modified="2022-01-19" version="1">MPYPQNVETARAVEQIIYDNGAVPATIAILKGKVHIGLNDTELDHLGKHGKQAWKTSRRDIPYVMANSLTGATTVAGTMVFAHAAGISVFVTGGIGGVHRGSEQTMDVSADLLELGKTPVAVVCAGAKSILDIPKTLEVLETQGVPVTTIGNNKAFPAFYTPDSGLQSPFHVTNAELAAEMIYANQKMGLQTGMVFAVPIPTEHAGDGENIASAIKTAVQEARSQGVYGKDETPFLLKRIGELTKGDSLKANIALVKNNAVVGAKMAVSLARMKSSANQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PK78</accession>
    <name>A0A8H7PK78_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_001165</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRN7/TAF1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PK78"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048538">
        <property type="entry name" value="Rrn7_cyclin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048540">
        <property type="entry name" value="Rrn7_cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033599">
        <property type="entry name" value="TAF1B/Rrn7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576:SF2">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20645">
        <property type="entry name" value="Rrn7_cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20644">
        <property type="entry name" value="Rrn7_cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="594"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2175518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="656" mass="75899" checksum="BBDC7FE83CEFE097" modified="2022-01-19" version="1">MAKAPKLPPCPVCKTKKYRKNATGNYVCKYGHQLANYHEEAAEEGNVGGNMRAISKNKGGPKMVKEKRRLYGPRATFLYYQMFQQCLRKMVQVLIKKFAAPPDLENAVRQIWLLYVAHSEIHFDYRRAAKSSQDASQSNEPEEDELEEDYEHNMSTAAAEAIAEENADLLDEGQTVTMFKTMSRWPNITYRHLLVFIYMGCVWLRWPILLSDLHRWSVVGKLPYVALTKDLPADFLEVISGYKLRDVKMIPSMPNLYYYTRWYFYAFRLRCNLKFPSSNYAPLVYRATRELMLPVESYSLAMYLMDEMENMHEVYPVDAYDARSARYLFSLCSIDIKIMAVAVFITKLFYKLDDAKTWEQPTGDDLYIPSKDNWLTAFRASKYRWESNLLNGGKKLPGEDEPDEENLRDMADMYKQTTHPNVSRQQKRDNILLKLLKNYVEELREKERINRVGAVGPVTRTKSSTGWEEGSTFTMIRDPYVRASMSDMEPLYRDISQAHSASDSGDQDDNRHEHRESFDEKYILKTGIARHFASQHLFSDIHSSEYDLVVDFASKLVGLTKADMIRVELSIESYLISKAQSQQHVLKAPKAKGPPGSMECFNCNVTKTSLWRYTSDGAHILCNACGLYYKEYESHRPLHIRQKPITVPSHNPLDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKS3</accession>
    <name>A0A8H7PKS3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_001340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKS3"/>
    <dbReference type="OrthoDB" id="429671at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="187"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2175693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="546" mass="60559" checksum="0D09BA48E8473531" modified="2022-01-19" version="1">MDTINQSEPRSNDDSNLSRESVRIPHTNICFGDLTREEINNVLTTAGASLIPPKSVPFATGGKQRIRRRQKPPGTKGNKSSVATTPDETTANGVQSQDSTQSSSEQAPVSVAPQPKPKPTSWAALLKPAQAKAQQPGAPATQISSNQNQQKASDSSDNDLPTSQFTGISTIVNTYQPTFDWTLLEPRGLINNVNTCFVNVILQPLVHCPPFYNLIKTIGQYVAHSFNSKTPLVDSLIEFVNEFKILSESGKPEEAFGAPFAPEYVYDALRGRKRFDSMKGRQEDAEEFLCFLLDGLHEEMIADVPKKEVVKELEEISSAVNEMDGWMEVGPKNRTSTVRTMEVPESPISKIFSGNIRSILRCSGSKDSVTLEPFQSLPLDITPDHVGSVEEALHNMTVPEIMHDYVSSKGLTVDATKQVFLETLPPVLVLHVKRFVYDNIGGVQKLQKPIRYDAELTIKPEWIAAAKRPTEPTKYKLFGVVYHHGVSAGGGHYTCDIRRQNNQWLHLDDTTITEIPESSVVMDDRAAKYNHFTGEQTAYILFYIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PL96</accession>
    <name>A0A8H7PL96_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 12">3.2.1.106</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_005360</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 12"/>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PL96"/>
    <dbReference type="OrthoDB" id="410058at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034840812" description="Mannosyl-oligosaccharide glucosidase" evidence="13">
        <location>
            <begin position="26"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="15">
        <location>
            <begin position="44"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="14">
        <location>
            <begin position="309"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2176127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="809" mass="91944" checksum="14885CF94FA1BB47" modified="2022-01-19" version="1">MPWKGTLAILTASATLLGSFDPVQSLSPQEAQLNVAAGKASNDSLLWGTYRPNLYFGTRPRIPESLLTGIMWFSGDNAQGFQHIRHACEQGDGLHGYGYFKHDGRSFAFQKMKDPLTDIELSTEFIKVPGGRHGGEWGVRIKGKPLTEGAMPVTNLVFYAGLEGEGGIDIVSKLRDDGLRSPVKLEGDSPQLGDFSIQITDGPSNQAPHSTLQRDLTRTYYWGLQSAEDMMWRAKDYFLEQVFGAARERSSKLTPDEAMANLPSLFLLSNTIDESESEVANLYFLQKVFEGAFELDIVFNSDSSVEHLKTQDLNNKLTAASKNFDQKFEQTFHLTEKGFKSLEEIEFGQFLLSNLLGGIGYFYGSSIVDRSHGAFEDEEYFTAQPMNAELTPPHELFTATPSRPFFPRGFYWDEGFHQQVIGKWDNDLSLDIIKSWVSQIDENGWVAREQILGAEARSKVPEQFQTQFPHYANPPTLLLAVQKFIDRLEKHTESQMQMSDEPVQNRMHVSTLDDPETLPNLHLNNPALATQWLTTIYPKLRLNWEWFRKTQKGHKPSTGNDEVYRWRGRSANHTLTSGFDDYPRAEPPSASELHVDLISWMAFSTRLMKSIATHLGEEYKSDVEQYDEVFQNLLSNIDTIHWSKDDQAYCDVLLTDSGLDPVCHKGYLSLFPLILGLLPADSPKLGAILDLIRDEKELWTPYGLRSLSASDPKFNTGENYWRGPIWMNINYLTLQSLHNNYMVIPGPHQEKAQQIYKELRSNIIKNVFEDYKRTGFVWEQYSAFTGEGKRSHPFTGWTSTVLLMMAEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMX1</accession>
    <name>A0A8H7PMX1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_005593</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMX1"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="9">
        <location>
            <begin position="76"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="7">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2176359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="242" mass="26100" checksum="A31A1AEAF596BE1A" modified="2022-01-19" version="1">MFSTRLASRFGSRMASNAIKARSFSTGARAGAVAGARKKLVVGAVAATAGYVYYQSTQAPILADSKSVAGVKGTDSERTFIMIKPDGVQRGLIGKVVSRFEERGYKLVAMKTVAPSKDLAEKHYADLKNKPFFPSLVEYMSNGAAPVVVKELSQELIYMSIVSVWEGTDVIRQGRVMLGATSPLDAAPGTIRGQYCVSIGRNAIHGSDSFESAEKEIGMWFSAAGELVSWEPANWKWVMSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PN50</accession>
    <name>A0A8H7PN50_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pumilio homology domain family member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_007941</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PUF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PN50"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000004">
        <property type="entry name" value="Pumilio homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="9">
        <location>
            <begin position="568"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="588"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="624"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="660"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="696"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="732"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="768"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="804"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="840"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="135"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="232"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="287"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="943"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="233"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00081811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2177284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="963" mass="108204" checksum="2015B5D8FCE77BA3" modified="2022-01-19" version="1">MYKGPVMMPRNFLDDQSIPANAQQADIYQPKATNQPQGQLAALIHGKMDYDLFNNPNNGLLSEISQDRVTSAPPSQANDLGMYQQDNLGSESQSGGYDSPQSWNLWKNTSSRHTFPDNDTEGDQQALRHNQQYGMDSHAGYGHQQNARQAKQQRPGVKSPIMDDASNQGFSRRGRLFDMIQDDFPRTPSPLFALQQESSQRQSSMNLGSDDMNAGSNADFEAMQKQYRDHFQSSDYKNGNPNAAMSPSQRQHELQQNSAQSAFQAGMHDKSSSAAISRINALRALSPPLRNNFSSPPPARSNSTPPTRSFDGQEQDQDYMNSRVFDSQAESLNRQLNSLGLNDEDNFSSYHPPRGLQAQAGANYESQFYGDNGMASPHLNQFQGFASPRADSGNDNLANSTWDNRDDYIRNPLTSDYYGGPNTPNDMMYRRSQQGGTPRAYDTDYVSFKRNQYGNQQGTTSIASAAAAMGLGPNGPMTAPAGLGLPGPQGAVKGPMGHMNEKKLRALQVQQQQLLIQQQQQLIAAREQLLMQHQMQPFNNQGIARPRAVNQEMNVRSPQPASDVTLGIRSQLLEDFRNSKSRKFDLKDITGHIVEFSGDQHGSRFIQQKLETANSEEKNLVFEEVLPNALQLMTDVFGNYVLQKFFEHGNQMQKTILAKQMEGHVLTLSLQMYGCRVVQKALEHVLTDQQASLVRELDGTVLKCVKDQNGNHVIQKAIERVPAQHIQFIIDAFHGQVYSLATHPYGCRVIQRMFEHCTEGQTGPLLDELHRCTAQLVQDQYGNYVIQHILERGREADKSMVVSKIRGQVLQLSKHKFASNVVEKCVDYGNKRDRQLLIEEVLQTKADGTSPLVSMMKDQYANYVVQKMLDVVDDDQRELLVTKIKPHMQSLKKYTYGKHLIQSKFSWGNTWPLRYLFCRILTTLPPFAEVEKLIPLINGTDEDQLNEANKNRPEEAQAVSIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNG5</accession>
    <name>A0A8H7PNG5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_007984</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNG5"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF22">
        <property type="entry name" value="GLYCOSIDASE CRH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034551542" description="GH16 domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="5">
        <location>
            <begin position="30"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2177327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="261" mass="28718" checksum="E7EB65456BF63F98" modified="2022-01-19" version="1">MVSFKLSSVIALALAGSALNINAAAVGKRDGAAIDKRPSYTGVKAVDNCQSFTDNFDPNTDLHQHWEKMNNASTYSLTSDGLEMKILNPRGSGLGPGSLFSSKRLMQYGFIEAKMKSAPAGGLVTAFIFMSPNGDEIDWEWVGDEVQTAYYYQGIPDFSSADAKALKDQSTNYHTYGIDWQPDAITWYLDGEVYRKVTKESTYKDGEYHYPSEAAHVELGLWDASGSESTAAWAHGPINWSEHPDHVSAHVKYVKVDCYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNP8</accession>
    <name>A0A8H7PNP8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="2">2.7.1.25</ecNumber>
            <ecNumber evidence="3">2.7.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_007820</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="11">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homohexamer. Dimer of trimers.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="2"/>
    <dbReference type="EC" id="2.7.7.4" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNP8"/>
    <dbReference type="OrthoDB" id="468at2759"/>
    <dbReference type="UniPathway" id="UPA00097"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010134">
        <property type="term" value="P:sulfate assimilation via adenylyl sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.10:FF:000003">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000802">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000052">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03106">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027535">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050512">
        <property type="entry name" value="Sulf_AdTrans/APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004040">
        <property type="entry name" value="PRK05537.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700:SF1">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-sulfurylase PUA-like" evidence="15">
        <location>
            <begin position="15"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="14">
        <location>
            <begin position="187"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="APS kinase" evidence="13">
        <location>
            <begin position="407"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2177163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="585" mass="65121" checksum="F37B2D8F8FD46BF4" modified="2022-01-19" version="1" fragment="single">LPFFPSNTFTTMANTPHGGVLKDIYLRDADKHDVLLAESEKLPSLDLDDRQLCDLELILNGGFSPLEGFLNQKDYDGVVENMRLADGNLWSMPITLDVSQERIDALGIKPAVRITLRDPRDDQALAILTVDDVYQPDKTKEAVNVYGADDVAHPAVHYLHSIANDFYVGGKLEAIQPPSHYDYVSNRFTPTELRAHFKKLQWTRVVAFQTRNPMHRAHRELTVRAARARKAHLLIHPVVGLTKPGDIDHYTRVRVYKALMPKYPNGMAELSLLPLAMRMGGPREAIWHALIRKNHGVTHFIVGRDHAGPGKNSQGVDFYGPYDAQDAVEKYKDEIGIEIVPFQMVAYCPDTDEYMPADEVPAGVKTLNISGTELRRRLKQGLPIPEWFSYPEVVKVLRQAYPPRATQGFTIFLTGLHASGKNSVARALQVSLNQQSTRSVSLLLGETIRSELSSELGYTKRERDINVQRIGYVAAELTKAGAACIAAPIAPYEAARQSAKAAIEKYGGFYLVHVATSLEECERRDREGVYKRARAGEIHGFTGIDDPYEAPGNADLTVDITTQSVSQIVHEIVLMLEKDGYLGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNU9</accession>
    <name>A0A8H7PNU9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNU9"/>
    <dbReference type="OrthoDB" id="2388351at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016071">
        <property type="term" value="P:mRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028322">
        <property type="entry name" value="PNRC-like_rgn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15365">
        <property type="entry name" value="PNRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="220" mass="24493" checksum="2CE63C0E57C07994" modified="2022-01-19" version="1">MISSQETESSLSKKTSPPKSQKPRSPRTKSKKTSKTSVEDQHTQTKPMKKATKQSKAESPTQRKKSNNSHKKSKSSRSQSPSTEVPQLSYSSTSGTESDDSEHLDTQLTPPMYSMNLNSSPSQHTKQNQRVTIAKQEVKYAGPTFSNAPAPDMLPLPGFSNKHAEAPSQIELQRRSRDLFNLLQPQAPMNNVYTPPAQVDRPMSLQDIEQGLRTFLKIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPJ3</accession>
    <name>A0A8H7PPJ3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_002978</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPJ3"/>
    <dbReference type="OrthoDB" id="1747252at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000001">
        <property type="entry name" value="50S ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2177731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="245" mass="26406" checksum="FD928395C94BBC47" modified="2022-01-19" version="1">MFTAKRAASLITARSTINIVQQTAGYASKKVVKVNPNALDLHEAIRVIKAAEVGRPQHQLEMHVQCKIEKSTPPIRGSIILPRNVKQEATILVFAEGKKAEEARAAGATYVGGHELIEQVKNGDLKFDKCLSTPDMLPAVAKIARILGPKGLMPTLKKGTVTEDILTTVQKSKGSFDFKGDKNGVLHTGFARVSFTPEEIEANLKAILDEVKAFGKAHSLKGVIRNVVLSSTRGPGIHISGSQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPM7</accession>
    <name>A0A8H7PPM7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_007640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPM7"/>
    <dbReference type="OrthoDB" id="10256463at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="105"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2176986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="288" mass="31979" checksum="1B64F1A22EAC3411" modified="2022-01-19" version="1">MAGKGQYNVIVEMDDEPTIQADSIDNDELQFQDFSSSSAGSNSGRINSGKQPFAASAPAGNFFDPHQQIQDQAMGRKPMWALDYYSQFFDVDTSQVLERCFRSLYPVGLFEEVLNDNPDLYGPFWVTTTVIFTTFVTSSLAASIVAYMSGTEYVYQFGTLSFAVFVIYSYTFGSAFLCWAATKYFGCQPSLLNIINLYGYSMTAWIPVSILCVMPYDIVRWILVAVAFALTGVFLIKNLYAIISRADAKTSRLLLIGILAGHAIFAVTLKLSFYSNDFRDASQETPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQ76</accession>
    <name>A0A8H7PQ76_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003042</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQ76"/>
    <dbReference type="OrthoDB" id="2287999at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="82"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2177795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="387" mass="44803" checksum="B301D3928F12FAB4" modified="2022-01-19" version="1">MSSNMVSDPLLIGCITWDFVVPEVDSIRVERSFSNVKLTKMERVSLDLVNQMTLQDCRNLVIAHNEKEVIVNGFSDDKTAPFVISLLRNCMQGCTCMTNSAPNSRGRKKTCRHMFLVNRALNKSFEWEQHVKRRKLPIEQVVLGTEPRSRYKEANDVTWERALMLIAGNHRDKIQVHSFTNYSKLYDIALDEEVMISCTCADEMSICKHMYLGQRVLNKLVMYERSFQNERHLTLKDILRMKEDKEIDKKKEAFQIWQQEAEDLVKLVRQRWGNPDWYEKENGTNEGSSESSKPSEDKDKEDTEKDEPAAKRQKIGDVTKESGEKDDKESTESIKRAALESFRQQAEMLGNLARAQKIDDIVQTWGLQQINSIIGDLRRMKQMLGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRL0</accession>
    <name>A0A8H7PRL0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_001672</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRL0"/>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase UBR2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="12">
        <location>
            <begin position="124"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="124"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="201"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="307"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="494"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="495"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2178826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="569" mass="63015" checksum="692DB8388FADAC80" modified="2022-01-19" version="1" fragment="single">MFMDSNDGGKDMFAIPSSPQSTALPLKRFLAQAPKRSLYQYNSIAEQAILVKCFQSLWHDNIDYMQKYFFPNATGDRRNLSSIIARRRQQLGAVGTTTLSGNTENVVLDEEDDGPEYWESQRGRQCGHVFKSGEAIYSCRNCAFDDTCVFCSRCFHATNHDGHDVSMSISPGAGGCCDCGDPEAWKVPVVCGIHSIEAADQLENEEDKEKSSSGTTSPGASATPRQPADSVPSDLKDSIRGTISGVLDFIIETLSTSPEEISFSRTAEEIEEEARETMIALGVLPDFSNKDDTNQNAFDGDIIEDMEDDASIPETRHRKTPKYGQSLEDSSMREKNPLQGSISDEDDDEKEIYALVLWNDEVHSFDDVIRIVTESIGCTAARARAIAEAVDSHGRDVILQSTNLQDLVHAAEIIASIGLAVTVRSARDVFREQICNLLCDWMKDIVSGHYKFFQGVEDGSCIIRDIICEELCREWALKPAIAALSTRYRRKSIIDDDSEGSDDDDDDGDDDTPFPAGPTMMEAIIMNTADDEEEGDDVDDTEMDMDMYELLGAEPTDLVDTHPTLARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRR0</accession>
    <name>A0A8H7PRR0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRR0"/>
    <dbReference type="OrthoDB" id="2282747at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="214"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="271" mass="30693" checksum="0B8A958F684C2CFD" modified="2022-01-19" version="1">MTNFASNRHNVSLERAQQTSMANKRWLLVGAQQAGASERRIAELAQLPRATVRRILSNFQRTGVPSLPPRQRRKVQDMSLVEYDEGGNITNHSEDVLSVKQRGPGKPRARDLIAYVLAQKALENEKKKQSHKKVQDFKSAPTLQPATSKPQLQVMTPPHESDKMPPSPTFEQAMVAPLGNDGRRVSLPPSPPLHPVLSSKRPCKDFQDIQGFEPWTKQDDLILLKQVFRSIRTDDWQEIDGKLNGRHNATMCQQRWAQLQSAMLKGFDELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSE2</accession>
    <name>A0A8H7PSE2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_001899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSE2"/>
    <dbReference type="OrthoDB" id="2246451at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2179050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="469" mass="53922" checksum="16B15AB02B1FF7D8" modified="2022-01-19" version="1">MDWQCFLRLVSLCSDESQSATSLKPYDPSQLAETIAELDKCFELFSELLEKLRACQSVEECASRYPEAGYILTRASLNAILAANKQINRLILQCLMEYCKLWDAPDRSLDQQDASKLWCLTRMRRLMHRPRATDSALVHLVKKITKSAQVRMFSLGQTEIHELSNYCVPLLQNSETHPIVLQLAKLACNVAQRHHDRETYCTLSPMFVNTLLEQHLRVYESWDLPVKQDLWSNFTSFVDYELTNLIESVFLHNGQVWHKEIDLIQRLQNSSENSSGIFLVTTQNRSSVYRRAFPLMAAIMQNGVDWRILQILETIHSMVVAQSSPPPPQHTPFSPRDNPLPDLLHTYLPHSIGQLLIRESVPSYVASVQQRIDQCLFKKLNDYELIRMQVWLLLMVSGSLLSLFAWHAVNPVEDEEVCVNITIQVPILLLLKLFPPVYRRLLRAISSAGYAVLLMTNDRDKPRKQCNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSJ9</accession>
    <name>A0A8H7PSJ9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_001975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSJ9"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2179125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="118" mass="13227" checksum="90B86DDC396FFDCA" modified="2022-01-19" version="1" fragment="single">MLEDHLPTVIQACRVTESVDARIKGISALQLLSRTEANKKKLVDAGALDVLVDMLKSVDEDIPETTHRSAAVALCDLIQSHDDRKIHILEIGVLEPLKRILTSETLRNNELKYWSLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSV7</accession>
    <name>A0A8H7PSV7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_003711</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSV7"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14500">
        <property type="entry name" value="PTP-IVa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000086">
        <property type="entry name" value="Protein tyrosine phosphatase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="29"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="102"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2179924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="232" mass="25574" checksum="F3D0D08525CC3C98" modified="2022-01-19" version="1">MNMINTTDGRYSSRARSSPLSRAFSVIETPAISLSPLRFLLLDCPTDSTLHLYMDEFRRLNVTDVVRCCQATYNSNRLAEEGINVLDLPFRDGGVPPPAVIGQWLKLVETRDREARMNASTSQDDPDMRPTIAVHCVAGLGRAPVLVAIALIEMGMQPLDAVEYVRRKRRGAFNKPQIAFLDTYKRSTKSVKSRSLSNSSSVNSTSSLKFSLGKMFRIGSGGGNKKEVVASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PT25</accession>
    <name>A0A8H7PT25_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PT25"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="823" mass="90513" checksum="D6A3B6D7E5D0D268" modified="2022-01-19" version="1">MNLTVKPQYTLFAPNTSKQLFMIHPTANTYGSHAPTYPQPTQIPPGVPNHPYHTKPIDDMMAAQQHQARQQHAVMAGAAAVQPQHPSMHYSGHNPMSAQPNLGQPQHPIPDPTPSMNDHGVQPVNIPQLAEFASSMVFLMWHARRPSVLALYNSSNTTSPVGTPPSSSSPTGAGATASGQHRQNISIGSSASPAFKKFCLQVLTATQLSESVVVLSLKYIAMLLQNNPNIQGAEGSEYRLFTVALMLANKFLDDNTFTNKTWSEVTNMKIIDLNIMELEFLDVLRFKLFVKQEEYERWKAALFKFRNQLSNVTDNEAQQQRQQQAQVIEATLRSMGLTSPQQDQQAWAAQQQQEVARRHAQAQAVQAQAVQQQQQQQQQQAVAQQQYQMYLLSKGQQPQFPLHPPSRPVHRVPLRLPVHPVYIPPPTVHTAQVIHSTTSPAQQAMMNSYYDNAVVAAANAHQQAANAAMAQQQQQQQQQQQQQQPPTTSAPGPGIGQSRTPQAVHYDTTPQQHTGLHQQVQPPQQGRTTPLSAGASGGFEYPPPTSMGQARNENMTYAQYNNYPGQAAPASMAHPTTSQPSYQQPVVSHAGTSGSAGYNQQAIQRTSSLPQGATSVASQSFPAVSTSQPSQSLYHYPTPNVTPSMPTNVRTPENNGPISYASQAPPNQTGFGNTHVASQPPRNYYGQDGHASAPRPAADYQYGPQANAQLDPRVQQYQGRSPMMRTPSTPGYYENDKYRGEEYTDRHDPNSLSVNATVFHPRQPGYYPQQQPPPQQYQARPQPSSGGPQPEDPRSAAMSYRSKSNGPMPEDPRTAADSYRSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTL4</accession>
    <name>A0A8H7PTL4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_003864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTL4"/>
    <dbReference type="OrthoDB" id="509821at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019176">
        <property type="entry name" value="Cytochrome_B561-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09786">
        <property type="entry name" value="CytochromB561_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2180077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="408" mass="46274" checksum="5BE839B107AA50A6" modified="2022-01-19" version="1">MFTKPQDKKTITTTQSEGSETWQAIKNLFTSVYNAFNSPAKPLPVPAQSTTQPAPAAAKDMYPSMHKLFPDLYPEQPPRASQPVYKQVEPCLDISALKANVASSRPMSATTPGVSGSQRERQLSSFIAQPTIAPGQSLQAKPTVIPKVMFQSCMLNQDIQLTDDSNTEADDSKKINISEIRKEQQVCFRYAMPNGELYINAKDTQYKDIKEQWDKLDELQCVEYCHRLRDWISVRMIRPLVEMMDKVNKELDANNYSHLNCYNCTLFTSTTSPSVPMPHSLYQLAQIYSNVPITNQRLDTEKYLLIPGFEQVEHRAYIIKRMKELGSGWRLAGFSIVKSEANQPTDRDIVLHIVKTYLSEMHTDVTPPLVDPPMDLMRFLVAYVWATPKLHYVFTGNHPDIDGSKKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTP6</accession>
    <name>A0A8H7PTP6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTP6"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="159" mass="17800" checksum="632CF86D4404E277" modified="2022-01-19" version="1">MDLRAYSDKDYDFVKSLYLKALSENTGKAVKSVMFQPRITRLLSLLLPAAGYMVFKGLTNFMLWSPQKSYAATLLSIGFVCLLIIASTYSMFAAGMKRSVTASFERDMADIPSSFDLKTINDGQSYHPISVSNRCKKLRDTEIGGLTKIPASWLWRDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTX9</accession>
    <name>A0A8H7PTX9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inclusion body clearance protein IML2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTX9"/>
    <dbReference type="OrthoDB" id="2154985at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="919" mass="103363" checksum="3180979B5FAC4A76" modified="2022-01-19" version="1">MAAASTLNSISSYGQNEEFPSQATIDFWVADTQRGLDAFFNDQFDTAQHIFTQYAGESPFHAIGFALMGYVEAMLGFESERIAVALARLSEAQNLAHSFAKRARHGKECVYEPKLGDENPSDIDMNELEIGQQPSLDFSRRSSSNSSAISGGSDNDEKRYSCPAHDEQKPCAHHLPSTGLIGMEYDLLEANCILMSATIQFLRDSWIDYMKAAYKLRKAYRMYEHMFEAITGTTTEKYDLKLRKEWKKQKQAPQSKEDAAFKISSPTPTCDLIENGSLLSSVSPSLTATLLTASPPPSPLPCINGSKTPSGCNSDANTIETSPSPASFNSKEASSFTDFLASTHFDAPKENKRHSLWAPNSPLETASFEPTLFSLADIQRKSAEADKAKKQQRRRSMPILNIDPTRKFSKDADWSDKSSSSFNTSTPISMVEKALESGVFFGVGLFALIFSLLPPKGTYRSYDSVVDIIDINLVNVLSASKLLNTLGFHSSRPFALHLLQSSYASCGLYSTLSSLTLFAYYTNLSLFLHPQLLPYSLRFRDIRIMLDKMKAKYPSGRIWMLIDGKLCKIEGFTRRGVETLRDARRRESGTRVKASASMAMFPDKVGKVTGQVDGAPRSRMQQQSMNGGMAQLQALAVYEMGWGQIWLGDYFQASETFFRLEGMNNWSRAFYHYIATCCMFADEEYDKAAIEYMQIPEILRRQEKFGGRLLPDEMFASRKIQSWKKKAEVLNPDNAQCLNGVTLKRIVVVNPLWELIYLWNGIPHINTDVLTNMKSKLHSQIVQLQKTPVECSSLVTNMTTESDVAILYLLYGTVIRELGEVDLSQHYLGKVIAMDQKITEDRWTVPYAMYELAIILAMDPTRANDAKVWIKRAETFFQGTLHYSARSPSELNTNNGGDTEWENRLHVRCQLLLERVEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUI0</accession>
    <name>A0A8H7PUI0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_008388</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUI0"/>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02657">
        <property type="entry name" value="Peptidase_C19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16104">
        <property type="entry name" value="Ubl_USP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="104"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="358"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2180809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="504" mass="56876" checksum="5FE11FA875E525D0" modified="2022-01-19" version="1">MVKVSVKWSGKKFDDLDLDVNESPELFKNQIYSVTGVPPERQKIMIKGGTMKDDTDLSKLTVKEGHTFMMMGTAGELPKPPPEPVVFLEDMSDKQLAQALDIPAGLENLGNTCYMNATLQSLRVMPELHTALNRYQGGITGMDTRGNLTASLRDLYKQLNNTSEGFPPLIFWQMLRQAFPQFSQSGAGGMPMQQDAEECWGELISVLRAKLPSDEASNQSFVDQYMTGQITSELKCLEAPEEQSVIDTETFSKLDCHISISTNFMQNGILDSLKQDIEKHSTTLDRTAQYQKISKVSRLPKYLVVHFIRFFWKPSERVRAKILRKVKFPLDWDATELCTEELQNKYSKVKAKLREVEDSKLEQERETKKRKMKNEIEGEGEGDSAHKDGPEETASTPKESTSSAMDTDPKKDSVDWSQYVDESLANDAGANVTGQYELCSVLTHVGRSADSGHYISWVKKGANEWLKYDDDKVSIVKDEDIQRLDGGGDWPMAYIVLYRAKQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVJ7</accession>
    <name>A0A8H7PVJ7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_008605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVJ7"/>
    <dbReference type="OrthoDB" id="2283488at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="67"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="705"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="729"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2181023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="758" mass="85181" checksum="CEE00666F5CF2E2A" modified="2022-01-19" version="1">MLAVPSTADNSASDLNSPKPTQSSGSHHHQQRNNSNQGHPDGGKNVDSFINEALDIFNKVGVASKMSLPHTSTSSTSDKGGTSFPETETADLNSDFKENEDDEEDDDPDAVTWKLKLSPSMMILDTNILTVSGLQKVLEQLKINVHPQAQYETVQSARINRSLVSPLPKRKAIMSAINSIYPPRQNADPSTLAFFQKLISSKLTNDCVDEFFSCYNEPLWFVNQSIFMSSYTSTNIADWTPEQDSTIDIVLQAAVCSMTVGHLLLVHQKLPSHGAVGLIESYYTRARDILEDHFDTIDLRIVTALLMLSQQSHAICGERLHSPLEQNALLILAVKMSQELGLFQIDRRKDILPDREQELEQGRRMAWVVLCMEFASSHNSTQPVGHIDLRFWKVDYPKHIPIESINTKPSVEFLAQYSKLIVIYKTGYQNTLRMLDQRPLDFSSIKSMAQRHRTKKLDEAAEYMELDVEQAIYGDLHQTMTSISHQRKRGLYCLKLYLTLESMALDYHISVLSISTSKDIQADDTHTDIGQSNADDQLRKSMSSAQIVNGSPMNSQMSPKPSSEVGTVSPELESYIMISIARAATTIMGLLELLLVIDPTTCHHEPFHWLLFLTEACHHLQSHSTDDELLLLCNMNANRAQNHLERMPLYHAGESAHVELMKRLRSRLGIKSQTSNAIPLVSEANLLRASAKDLMQRLEQRPEMIVDSQAAWSPPRPSSIPRHSTQTSDGDHQVKLEQYDEKITPHDDGYSSESSYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVP4</accession>
    <name>A0A8H7PVP4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVP4"/>
    <dbReference type="OrthoDB" id="2141050at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2180061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="83" mass="9032" checksum="D440FD625A45BB2E" modified="2022-01-19" version="1">MTLVGSVAGFATLGFTVRAYALGIQKRPIFEGISGHFLTAGAFGAAGYWIYNLQNKQIEQIENKKKLLLSNRARVESAVAEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVS4</accession>
    <name>A0A8H7PVS4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 15">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="5 15">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_008553</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="5 15"/>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVS4"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000185">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000027">
        <property type="entry name" value="protein disulfide-isomerase A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034862701" description="Protein disulfide-isomerase" evidence="15">
        <location>
            <begin position="29"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="17">
        <location>
            <begin position="12"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="17">
        <location>
            <begin position="322"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="471"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="59"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="391"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2180971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="497" mass="54320" checksum="BB63E1322E8C84AC" modified="2022-01-19" version="1" fragment="single">FTFNLSTMVKSSFILAAAASAFLTFVQAKSDVVDLDAKSFDKHVQKEDLTLVEFFAPWCGHCKALAPEWEKAATELSGTVKLAKVDCTVEQDICTGQDVKGYPTIKVFRNGVPSEYGGPRQADGIVSYMKKQMLPAVSKLDAKSYKDFQTTDKLVVIGYISSKDKETQEIFEELANQLRDDYTFGLVTDKKVIAAEGYEGASKIVMYKEKEPSLVYDKEIDTAEIASFIKLNALPTFGDIDGSNFASYADLGLPIAYSFYADKDQAEELDAALRPLAEKYHGKLSFVKIDGSQFSGHAEALSIPTEFPSFGIQKLDDASKYPLLGKKATDVEAVDALAAAVTEGSAQPHLKSAPIPESNDEPVKVVVGEQFDKIVLNKDQHVFLEVYAPWCGHCKNLAPIWEELAQHYADDKNVVIAKLDGTENDLPASAGLKIEGFPTLVLYKKGTNELVNYNGARSLEELKEFVDALDATEASGEEAAPEAEAVPKAAEESHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PW75</accession>
    <name>A0A8H7PW75_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_008582</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PW75"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000004">
        <property type="entry name" value="Pepsin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034456064" description="Peptidase A1 domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="8">
        <location>
            <begin position="75"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="106"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2181000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="387" mass="41920" checksum="08C489FF938257C0" modified="2022-01-19" version="1">MMQKFTALFALVNFIGVVLSSPVVNRRELEISTHSRPVEIQDRNVTHAKGFNRKHVQKFAVAKEKQVAYMGNTGYFGEITIGEPPQTFKVVFDTGSSDLWVVSDDCTTEEYCQAHSRYASSGSSTFASSDEEFSIRYGTGAVSGRLGTDTVSVAGLTIPEQSFAIASTLSDNFAYSPFDGILGLGFPSISTSGLQPPFHNMMAGGLLDEPVFAMYATKEGGEIDLGGIDKSRIQGDITYSNIIEEGYWKIQMDKFGVNGQKMGTRRAAIVDTGTTLIIVPVADAELIHDKIPGAVSAGDSSYLIPCSIKDSDFVLSLWFNGKVHNLKGADLVMAPVDTKRGMCLSGISGQEFSKSTPTWVLGDVFFRSFYTIFDAGKSRVGFAQIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PW86</accession>
    <name>A0A8H7PW86_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_008555</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PW86"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041672">
        <property type="entry name" value="Bap31/Bap29_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18035">
        <property type="entry name" value="Bap31_Bap29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="13">
        <location>
            <begin position="3"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31/Bap29 cytoplasmic coiled-coil" evidence="14">
        <location>
            <begin position="163"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="150"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2180973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="215" mass="25136" checksum="54FD41C355FE38F4" modified="2022-01-19" version="1">MSTLPYTLVFILLVLEMTMFGLLVLPLPPHWRGALLKFISRSPMVSQCLYVMKILFVFVFLLFADSVNRLSRVQTPTTNNGNMYGHDPRLDAALSSKKFYTQRNLYLTGFTLFLSLILERTYKLVLENVHRGEEIKSLKNQSTTASKDYERRLAEKIDEHKLEISKLQKQIDNKSTDLETLKKQCKQQSEEYFRLADQHNELERRSLPSETRKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWE8</accession>
    <name>A0A8H7PWE8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_008702</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWE8"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="31"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="197"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2181120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="47591" checksum="6639DD740253F349" modified="2022-01-19" version="1">MRSFLSKNRIAIDLVEPVVYLRGLQDQATHTTIRGAVKLDLKDSATIRSISLRFLGNSRTTWDEDGPSGVIGQSKRYDSFKSFINSVIPIYQASEAGLQQQLVLPPGRHRYPFEICLPNSLPESVDMSEAKVSYKLIATVEDDKRQNSNVIPEFLKSSQDTAEAAIQLVRLPSNADLTNDNSGESITSHHHQENLCDFDITIEKSAISPGSLLPVSLQVTPLMKGIRIEQIHGRLQERRNLQIPEQQAKRSSEKNHFLEQKGPSKNAVKADLDSLGGQWGKRIVFAMPESQNRPKLHHSTDAHPEISVQHWLQLSVWVSCPEPGTKNKRMQKSLVFDNQINVLNQCVAGHANEDCVALPIYQKAARDPSISKNQTLNRYMSGGYRAYQLVEPCNPTVQPVVNQDGAPLHPPPPEYNDIFETPQVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWV0</accession>
    <name>A0A8H7PWV0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">mRNA export factor mex67</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_008871</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWV0"/>
    <dbReference type="OrthoDB" id="25872at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14342">
        <property type="entry name" value="UBA_TAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057125">
        <property type="entry name" value="NXF1/2/3/5-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24048">
        <property type="entry name" value="LRR_NXF1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03943">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00804">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="9">
        <location>
            <begin position="375"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="TAP-C" evidence="10">
        <location>
            <begin position="569"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2181288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="626" mass="69504" checksum="743CD8D09EEB7025" modified="2022-01-19" version="1">MAQPRGFAGMFGNAVAKLTDIRPISAEDVGMGETNRSGGGKANRISRRDRKNQTAKGSLRAVVKASEDIDMKGTVPTGRGKFDPYNRSGRRATFTRDVVQGAKEPKEVVITGYAPGTENGLLQFLQQKTKTPWKVLAVKFVEQSLHIMVENIVVAKRIQRLTGYAYETNQLSVYIVEDDPSLIEEGTGKSTVDTLRSFLSRRWDASTKYLNLEAIADDAVLQDAGIEIPGSEDSNKVGGALMKLAGEMFPDVITISFARNQISKLKPYSLIAKYIPNVQHISFQHNKITNVAQLGFLGASGKLPKLKELILSDNPFRDKLIEKDPTGATYVKDVIKVYPTLQILDGQHINSGKSKQDFPVPCLGGFIDNDVTGPLVDAFLEMYFGSFENDRNLCINLYAPEAILTVTTNLKLGPAKARSKQERLANKKKETYTWETLNRKVGTKSKNKDNIFCGQDNIREALARLPATRHNLDKKEMIIDAFMLNVIPGYPNAINLHIHGDFISGETSTKRTYSYDRILIIAPSLPGSISQACGAPFTILNDQLRVRDYSKLPDWPTATLPTPPSTETDLRQKLIDDVQRISGLKSEFAIQCLQENNWDVQQAIAAYQRLREAGTIPAEAFVHHRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PX62</accession>
    <name>A0A8H7PX62_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">VLRF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_006847</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The VLRF1 domain mediates binding to the 60S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ANKZF1/VMS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PX62"/>
    <dbReference type="OrthoDB" id="429841at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047139">
        <property type="entry name" value="ANKZ1/VMS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041175">
        <property type="entry name" value="VLRF1/Vms1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036">
        <property type="entry name" value="ANKYRIN REPEAT AND ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036:SF2">
        <property type="entry name" value="TRNA ENDONUCLEASE ANKZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18826">
        <property type="entry name" value="bVLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52044">
        <property type="entry name" value="VLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VLRF1" evidence="12">
        <location>
            <begin position="217"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="553"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="553"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2181922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="647" mass="73443" checksum="C1C392056777B196" modified="2022-01-19" version="1">MVKHPKNITLSYLRKQHINVFRVPEELLAIMVRHDDNVPNIVPPVEESPRLIDRSVDSEGNPVLTCSKCGIQFEGSEKERQRSHFRSDWHRYNVKRGLEHPNLPPVTEQQFQDMLEDLTESISGSDTDESASDNESDGSADDNVNILISKEKLRMAALERAKLKAEQKQKVHLHNNSPLSWYTAAPALPENVHLGVYNCVRRNVHAPLSADQLPAGYTRTWTMIMVGGGHFAAAVIDVGKSQAQENNSSRATSVIAHKTFHRYTTRRKQGGSQQANDNAHGTASSAGSQIRRYNEVALQQEIRELLSQWRKYLQESDTIFIHAPSANRKIIYGYEDAPLDINDPRIHSFPFTTHRPTLNEIKRAFFELTDLKLFEIDDATLRRHEQDLACAEEARLQAISKFEELSMASPSEPVGSVEPDAPKPDADIEKAILLTKQGKVHVLKSFIERCTQQGKNLPVVDMLPATTKIEDSRRLTTLLHVASNYNQSDMVNYLLRECNADPTIPNEGGKVPYDLTKEKAVRNVFRRCMSDMPEKWEWLKGAKVPSPLTAEMEKQQLEKEEQKRQKELETRRKIEEQKRKKEERKLANAPAEESSLKVNKASPLQGIYGGNAMNTASMSPEARMRLEREVRARAAEARRAKVMSERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXN8</accession>
    <name>A0A8H7PXN8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXN8"/>
    <dbReference type="OrthoDB" id="2273669at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2181036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="504" mass="53662" checksum="3771B62A896EE519" modified="2022-01-19" version="1">MSDKFSDDDGFYDTEDEEWDAPITASWGVPAAAAAAPEAQDQTSETADVNGWHQIADPNAKIRADGVGAGNLHRKGKNFQPVDEQHILNQRLGKAIPKSKTKQIAVAKKATKVSIQPIAGNKPPHVLSVPGTGKKAAKKARSSALSAAAERARAVERAAAAKQPAKHMANPDPHVNSVWKAGTSLADTPFWEQASSRQSIHAPPTTKAPTRTPAPAPVHPPVHAPARDPAPASALQPTKERRLQSPTQPAPHKEPTKFTFIPPSESQQLPQPTKFTFFPPPPEFQQPTKPKVEFQIKGAAESIRKVKAANAAVTSDVPNKSKPKREITIGLPKPKQEPKLPISTAKPVAPPPTAPAPARARASVPPAAPALAPSKPVKPAQPAQSAKVTKPNPPEPAPQPTKSAPPVNKTGAGSSDSRWASTPSNASPSCQKQAANNPVIVTLNIELEKGEALPIIVRAKDDPKELATAFVERLSQRKNNISIDNNIVQALTQLIEQKIRDKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYF7</accession>
    <name>A0A8H7PYF7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcriptional adapter 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_007469</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYF7"/>
    <dbReference type="OrthoDB" id="270417at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070461">
        <property type="term" value="C:SAGA-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02335">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000110">
        <property type="entry name" value="Transcriptional adapter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000087">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.90:FF:000008">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041983">
        <property type="entry name" value="ADA2-like_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016827">
        <property type="entry name" value="Ada2/TADA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055141">
        <property type="entry name" value="TADA2A_B-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF20">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 2-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22941">
        <property type="entry name" value="TADA2A-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25299">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025024">
        <property type="entry name" value="Transcriptional_adaptor_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="12">
        <location>
            <begin position="28"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="14">
        <location>
            <begin position="88"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="15">
        <location>
            <begin position="93"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="11">
        <location>
            <begin position="93"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="SWIRM" evidence="13">
        <location>
            <begin position="393"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="366"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR025024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2182538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="497" mass="57252" checksum="B1A2ADFAC3A269B3" modified="2022-01-19" version="1">MTITHRNKPQATAGTTGAPSSGSDDKEPPKYHCDACSTDVTNTVRIRCADSDCPDFDLCVTCFCSGVEPVKHKSWHDYRVVKPHSFPIFAEEWDADEELLLIEGAEKMGMGNWQAIADYVGTKNKEECEKHYLDVYVNSPYWPIPDMSIEFNMSEDEYRQRKRQRLHAMSGRSPAAPARSQKPITSGPTFHEIQGYMPRRYEFETEQENEAETFVKDMVFNEDDTQEEIDLKVMVLDIYNSRLDKRIEKKKFILERGLLDYKKTIAAEKKRTREERELYNRTRVFARLQTSEDYEIFVEGLLKEQRYRDRIVQLQEWRENGITTIKAGEQYERDKIQRTTNLKGLIAREAMLANERNHARNTLRAQLATQSGRESSPASRGSTPKPSSASQVAAGRKPANPLNIKEADGVHLLSEDEQQLCSTLRILPRPYLVIKDTILKEYAKHGYLRRRQARELIKIDVNKTSRIYDFFVESGWIKAFKSADNTSNQPTASIAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0X4</accession>
    <name>A0A8H7Q0X4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0X4"/>
    <dbReference type="OrthoDB" id="2372811at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="302"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2183505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="463" mass="51159" checksum="94919275D523E186" modified="2022-01-19" version="1">MTSEVYSGLSNGCTSQFHSILPRTINALSSGRSTPVPTPSSTPTPRVNHDQNEVLAVALELEQPSKCFYPGQTVRGRLHIHAQETIGIQYIRIAAIGGLGLRSATKHDAPELHGGYELVVLNTGVRVTRQGGGGKDHITGRSRRERWRLSYDRVTLPAKSGRYDDSDAEQDDGDAMETSSRGSRRDSKYASMSSYGSSVDSYFMLDTRSHEIPFALPIPRNNVIPPSYKSSQCQIQYEVVALLHYETMDSSIVHVKQSRQLIRLASLTPTSTPLYNSPIIAKSPRQPVTTHQQKKLKSMPTSAGWIEASAYTPRRAFLPSDAIPLSIKINNYSDFHPCQATVEAALVQHLLNSTGLNIGNNGEKINGVIGVFDGISERDQEVNLDMDSLLSIPGKCCSTIFSDMTQGMLEVEYKVRIKVTLTGFVKAKKKFSCLRRNKIDEKVNHVAYMDFPIVIGSLRKCDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q152</accession>
    <name>A0A8H7Q152_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Ubiquitin-like protein ATG12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_006134</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7">Forms a conjugate with ATG5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Preautophagosomal structure membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATG12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q152"/>
    <dbReference type="OrthoDB" id="10003551at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01612">
        <property type="entry name" value="Ubl_ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000150">
        <property type="entry name" value="Ubiquitin-like protein ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007242">
        <property type="entry name" value="Atg12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385">
        <property type="entry name" value="AUTOPHAGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04110">
        <property type="entry name" value="APG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="5 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2183139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="129" mass="14452" checksum="B40CEED828FAFF19" modified="2022-01-19" version="1">MEGSEVGNQQESNKDKETTEHVASPTETLEQVIRQKKEKDITKVIVQFRAIGNAPILKQKLFKITASQKFQAVTIFLRKELNYGASDPLFMYINSAFAPAPDEIISNLYKSFGTDGFLVINYCTTAAWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q175</accession>
    <name>A0A8H7Q175_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_006663</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q175"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032161">
        <property type="term" value="C:cleavage apparatus septin structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043934">
        <property type="term" value="P:sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000260">
        <property type="entry name" value="Cell division control 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="7">
        <location>
            <begin position="24"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="305"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2183655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="336" mass="37634" checksum="E0C5CBCF6520E379" modified="2022-01-19" version="1">MSGLNGYVGFDTITQQIEKKLLKRGFQFNVMVVGQSGLGKSTLVNTIFASHLIESKGRVAHDEPPRQTTEIETVGHIIEENGVRLKLNIVDTPGYGDQVNNENCWEPIIKYIKDQHSAYLRKELTATREKYIQDSRIHCCLFFLTPSGHALKPIDIVVLKKLSEVVNVVPVIAKSDALTLEERAAFKQRIKQELTFHNIRLYPYESEEDDEQEQALNESIRDLIPFAIVGSERNVVVDGKAVRGRKNRYGVINVISSAVENEEHCEFVHLRNFLTRTHLQDLIETTAQIHYEAFRSKQLLAIKESTQQPQSPGAVSSPTNGNVASPALTSPTASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1D9</accession>
    <name>A0A8H7Q1D9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1D9"/>
    <dbReference type="OrthoDB" id="1001765at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00657">
        <property type="entry name" value="Ferritin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052965">
        <property type="entry name" value="Pigment-catalase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694">
        <property type="entry name" value="DESICCATION-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694:SF26">
        <property type="entry name" value="OS05G0151100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2183745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="281" mass="30720" checksum="20196C6E09106CF2" modified="2022-01-19" version="1">MLFAAAGIVKAAPLERRADAYTDLDILNYALTLEHLEDTFYRQGLEKFSAEDFKSCDLDETVYDRFKAISQHETTHVAFLTSAIKAAGGSPVPQCEYKFGYTDVQGFVALAQLLERTGVSAYDGANQYIMNPAYRTAAATIVTVEARHSAFLNSITNRSPFPYAFDTPLSLNEVITLAGGLISSCPYDVGIKPYNTLTVTTTSEKKDKLKLSYPNSNDNQYAYFLWGSNTTSTQIGSNGEIEVPKEITAGDVYIIVTSDNSPPSDSNIVAGPAYYSVPANW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1M2</accession>
    <name>A0A8H7Q1M2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spliceosomal protein DIB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_000361</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DIM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1M2"/>
    <dbReference type="OrthoDB" id="147752at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR017199-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2184452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="142" mass="16787" checksum="DAAD315024176857" modified="2022-01-19" version="1">MLYFLPHLTNGWQVDQAILSEEERVVILRFGHDWDPTCMKMDETLYGVAERVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFYRNKHIMVDLGTGNNNKINWSIDDKQEMIDIIEIVYRGAHKGRGLVVSLKDYSTKYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1R3</accession>
    <name>A0A8H7Q1R3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Propionyl-CoA carboxylase beta chain, mitochondrial</fullName>
            <ecNumber evidence="3">6.4.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Propanoyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_000421</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>butanoyl-CoA + hydrogencarbonate + ATP = (2S)-ethylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:59520"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:60909"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:59521"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57327"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:23721"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The holoenzyme is a dodecamer composed of 6 PCCA/alpha subunits and 6 PCCB/beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.3" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1R3"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000017">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit beta 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000016">
        <property type="entry name" value="Propionyl-CoA carboxylase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051047">
        <property type="entry name" value="AccD/PCCB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842:SF2">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="9">
        <location>
            <begin position="41"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="10">
        <location>
            <begin position="287"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2184512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="546" mass="59385" checksum="442746E46C9BF989" modified="2022-01-19" version="1">MFRLSAVHSARQALLKQHLFTAQRYAMPAITRAYATGGSRENAAVSMIERKRADAQLGGGQKRIDAQHNKGKLTARERIDLLLDAGSFREYDTFVEHQCVDFGMEKNKITGDGVVTGHGTINGRKAFVFSQDFTAYGGSLSKMHAQKIQKVMDKAMLVGAPIIGLNDSGGARIQEGVDSLAGYADIFQKNVLASGVIPQISLIMGPCAGGAVYSPALTDFTFMVRDTSYLFVTGPDVVKAVTNEEVTQEELGGASAHTVKSGVAHNAFENDIEALQRLRDFFDYLPLSNREAAPVRKLDESAIKDDPSLDNIVPVDSTKAYDMKDVISRIGDENSFFELAPAYAKNIIIGFSRLNGQTVGIVANQPLVSSGVLDINASVKAARFVRFCDAFNVPLVTLVDVPGFLPGTGQEHGGIIRHGAKLLYAYCEATVPKLTVITRKAYGGAYDVMASKHLRGDVNVAWPTGEIAVMGAKGAVEIIFRNSTNREQAEKDYVEKFANPLPAAQRGFIDDVIMPSTTRRRLIEELSLLKDKKLSNPWKKHGNIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1U8</accession>
    <name>A0A8H7Q1U8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein bL31m N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1U8"/>
    <dbReference type="OrthoDB" id="5587740at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034600">
        <property type="entry name" value="Ribosomal_bL31m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048874">
        <property type="entry name" value="Ribosomal_bL31m_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL31M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21492">
        <property type="entry name" value="bL31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein bL31m N-terminal" evidence="2">
        <location>
            <begin position="24"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2184889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="136" mass="14672" checksum="606F6D5ECA4D4A55" modified="2022-01-19" version="1">MLVAQRISSAVRRQTASIAVRHASGKAASALPEQFTQTIVLSNGATYNVRTTSPKAQVRLTKDTRNHPLWNPSMLREGVNDESEQLTKFQKRFGDLGGLEDISFVESDEAVSKAMQKAAASGGQTAKAAKGKGKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q260</accession>
    <name>A0A8H7Q260_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q260"/>
    <dbReference type="OrthoDB" id="10287779at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="117" mass="13339" checksum="F199669F7F535E35" modified="2022-01-19" version="1">MQSGKLICRYRATLSSRIIPTAAAFRQFSMSAPSFNKKEEGGPRSVTHTYFEEMKDYDEEESKSYEKDRVDGSFWGGDPGQQQEGDKNEMVDENSPNVHEAYKDSNKSEKKSVRGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2F6</accession>
    <name>A0A8H7Q2F6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_006457</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2F6"/>
    <dbReference type="OrthoDB" id="415358at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040577">
        <property type="entry name" value="Gln-synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052725">
        <property type="entry name" value="GS_Type-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022147">
        <property type="entry name" value="GSIII_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42974">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42974:SF1">
        <property type="entry name" value="TYPE-3 GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18318">
        <property type="entry name" value="Gln-synt_C-ter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12437">
        <property type="entry name" value="GSIII_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="3">
        <location>
            <begin position="91"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="4">
        <location>
            <begin position="197"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2183451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="755" mass="84399" checksum="10493B7B4BB4AC1D" modified="2022-01-19" version="1">MTQEARVSTVVESLTKAPRNIAFPQKDGRPQLISEIFGQNVFSFKQMSTRLPKPVYNTFLRQLRGNETIDKNTADAIAHAAKVWAMERGATHFTHWFQPQTDSTAEKHDSFLTLKSTFEKGFEEVECVDTLSGSQLLQSEPDASSFPSGGMRSTFEARGYTIWDTKSPMFLQEGPHGTSVLYIPSVFISYNGQALDEKTVLLRSSEVLAKNAIKVLDLIHDPENEHRVRQVHTSLGTEQEYFLIDRALYTLRPDLKITGRTLIGGLPPRHQQLEDHYFGKIPSRVLAAMSECEYELYKLGVPCKTRHNEVAPAQFELAPIYEEAMIAVDHNLLTMDVLHRVAHRHKLKVLFHEKPFKGVNGSGKHCNWSMTTDSGINLLEPTAKPEKNLPFLIFLLATLKALQDHGDLLRAGIASASNDHRLGAHEAPPGIISAFLGDHLTEVLDSIEQDRPVKAFNSPEMQSVRVGGTVLDLKVATLPNIARDLTDRNRTSPFAFTGNKFEFRAVGSKQSVSFPVTLLNSAVASALEEVAAELEKQKGDKEYASEEDQIAVIKHFIKLTKDVRFEGDNYSDAWVEEAEKRGLPNIKNSYDAFSRLREARNADMLEKVGVFSKEELHSRYHILMEKYAKDVRIEAQTLHTMVVQQILPAAFAYRKELAEGASMLKAVDAGAEPELKVLKELTPILTNLQAGIVDLEKQIAASDDITDDIAALGKHSQAELLPAIENVRSYADALESIVGDKFWPLPKYTELFLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2P9</accession>
    <name>A0A8H7Q2P9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="6 7">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_000760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="6 7"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2P9"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05927">
        <property type="entry name" value="LC-FACS_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045311">
        <property type="entry name" value="LC-FACS_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="9">
        <location>
            <begin position="78"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2184847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="692" mass="76493" checksum="9B558E4B8209481B" modified="2022-01-19" version="1">MVSGKIDFNRQSVEVPNSRKPGQTGYFRNAAHPNELVAQINPKVNTIYEAFRQGLKISRDRPCLGSRPIIDVKTGKRGPYVWETYRQVSYRITNLGSGMFNLVDSVLGAERGRASLPIGLWATNRAEWFIADMATAAYGHYSVALYDTLGPDTVEYVTNHAEIEVLVTSADHIADLLKLKHKLPTLKIIVSMDRLDDDVAPVAGAPNKSAIIKAWAEEKGIVLVDMYTLEQDGRKAKRAHRAPKPDDLACIMYTSGTTGVPKACDDYGAMLSHRNFVAALTGSLLNLDSNQDDCNISYLPLAHIFGRVCDLSIIQAGGRVGYFSGDVLQLLDDMQALKPTFMASVPRLLNRIYARIASQTIEAPGITGVIARKAVAAKLENLNNGGTYAHAFWDRIIFNKVRQALGGNVRAMITGSAPIGKDVMQFLRIALCVDLREGYGATESCAAISVHNPGEYRAGHIGAPFPHNEIKLVDVPEMDYLSTDPYPRGEICARGPNIFLGYYKDEEKTRETVDSEGWLMTGDIGMIDERGCLIIIDRKKNIFKLAQGEYIAPEKIENVYAKNTLLAQLYLHGDSLQNSLVAVVVPDPEALSALAAKVPAVASNKLSYQELCKHPEIKKALLEEMNKTGRKGGLRGFEFARNIFVESEPFTMENDLLTPTFKIKRPQAAKFYKTQIDAMYEELDRQTVKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3L7</accession>
    <name>A0A8H7Q3L7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-galactosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3L7"/>
    <dbReference type="OrthoDB" id="5348797at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021459">
        <property type="entry name" value="GH101-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11308">
        <property type="entry name" value="Glyco_hydro_129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034948790" description="Alpha-galactosidase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="646" mass="71076" checksum="8BEDAA3777C4A820" modified="2022-01-19" version="1">MKRLLLIAASSALSTCVLSRAVNCHPSASPCVDSKYVAIGINGGIARITLATLEIKMHIDEAKLLQVSAPAKAIGNGDFTAEDVSTHNGHVNWTLLPLQYKVSAYEEDGRLAVSIHANNGTIQWPTTTSSGSLLLPRGPGLHIPTQDTFWNSEEAGLLDSGVEDISSYLNMPFWGYQVNQSIGFSYILPEDIGTTLSHTSINGQLALKFNHTFQSEEDTLSYKTLFELNNGSLLAPAMSYRKYLLKHQGLVTLKSKIQKQPNTKKLLGAFHTYVWGPGGLTVDAMHNMTSLGIKKLWIGYDANGNPMTGAAVGAAQDSGYLVGPYDTWANGQDPKTADSSVFSWPEGVYTQQCVMQDGEILIGFGSRGCYLSSQAQKLSEPHSHNIADRIKNMSSNGVEAYFLDVDAASELYTDSDPKHAMNQKTDRQNRLERLTMLSEHFVVGSEEAHGWSNSAVAYGHGSFTPVDSRVYPELERNTTLWGKWYPVAAPGFFFQEVQLLDKFVKTMFDPVYRLPLTEAVMHDSIISLDRWEMSLYKFPNVVNNRILLSMLYNCPLMLSIDGAMLQQHGSAIAKYQNFFQPLHELGALVTLDAFSYLTDDQQVQRTEFGSGSLIITANFGNSDYNTVKSGCVKAELHGKPATTLCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3M1</accession>
    <name>A0A8H7Q3M1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3M1"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000431">
        <property type="term" value="P:regulation of cytokinesis, actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026817">
        <property type="entry name" value="Ect2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16777">
        <property type="entry name" value="PROTEIN ECT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16777:SF2">
        <property type="entry name" value="PROTEIN ECT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="102"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2185864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1017" mass="114563" checksum="E1D38344652499A0" modified="2022-01-19" version="1" fragment="single">ILRTTLSESGFIYKCKPVNSKTIPETGFQEGSSQLQPLCQFLDVLVDDKCLTTTSSDERQHFQQFVNSIGHSTIHGPYSLKTDRVTIDPCTLSNDFVLDDERRQSLIEELITTEENYVGNMTAFCNLIVSPLRLRAKGKQHILGLYQCNTIFNNIEQILQVNQEFLAELQSWKLVRDNLFGDICAKYMYNMECYTKFLQGVDAAQEINIQEQKTNHLYRAYLQVAKQNPSLGSQTLYDMLAQPGQRIGRYTMLFKEILKHTSPSVQDHSSLVAALKKAEEIATLADDSPVRLAKIFFNMHRSIQNCPASLISQSRTLVSHLDAVELDPSTLKPLRPITVFLFTDKLMIVRRPAYNLRGLDLCGLQSDSPVFESKLLKKLEKNVMKPDRQLKFKDWVNLEDVDLLQGNQGMRSAKPIVSYENSSLPTAELMTSFRLRARNTSSKLNAQISGHESSNYFADQPIRLFAVSFNDIQYNNTVNDRENLQIKATFVKLFGRTKARIYQNEVMTTTYHREWNNINLYSNLYSLDQYNLCNHKSDVCVIYVEHVSDDDARFVAEISDRPTVAMMIEPISNDCYRLNVRSKSKLKANGATDSTSSLLQYEFADVLCANILYFSMKVNSQTDASVDAQKALRRRNSRGVLVSPTLSTSRLLGGTSYLPLVTTSMSTSRPRPKSTASGSDILKNIESRIARRNSYASTLNSKPSVDSNISLQSNNSDVEEPTNQSGLSVASNVSFENEQDLDDGIILSTQKLTTSKVVARARRLSIADQGRAQTSRKSSFRLPPVSVSDGPLFGPMIDVEPVARSASRGSLSSSIHSSEPGSVFSTITSRTSTLSTMSNNSKTRKGSVEQNVSQMMRWMQNQQAKSSLETRISSLEKFMAVADKLKGDLSARCESLMDTYEQLKLTQEVLIRKVKEKDGEIESIQNMYQDAIDENQILYQTFNDELDQLLKIVARESSSDHRPAHPTPEEQIKRKLKAVLKERNEWQQIASELEKKLYGMTTAQAQNSNPNAATHDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3W3</accession>
    <name>A0A8H7Q3W3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_000488</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3W3"/>
    <dbReference type="OrthoDB" id="19606at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055412">
        <property type="entry name" value="UVB_sens_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24160">
        <property type="entry name" value="UVB_sens_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="7">
        <location>
            <begin position="107"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Root UVB sensitive protein C-terminal" evidence="8">
        <location>
            <begin position="370"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2184579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="503" mass="56231" checksum="5987C0D5707656EA" modified="2022-01-19" version="1">MQPGKAIQSRIFRGLSTQASGPQPSDEQQKPDHTILTEYVSGRTRIFTSLPTGAGSGRGSKQSPSSPLTSPLSWQWLQPQSSQMGRKASRWSQKRQKLLNLGVFSGLRQSMREMFLPVGYPESVHECYAKFHAWLFLETYVGSAIGVLCSQAMLASLGLGEAEAAGGAVAIQWVLKDGIGEVGKLFFIKRFASSFDSHPKTWKMVCEGFSSVGSALQLCTAYVSPKFFLPLAATGNMFELIHYSIWAASHMTFTRNFALSGNVGDIVAKDDAQMSTAHLMGMISGVGLISISHDPTFLFSAFAILSPLNIWFTYKLLKTAQFEILNQAKLTLLSRSYIDTGKVVDIDDLKDREFMFGEFIKKIPGRGGIAVNIKLGAGADKAFRGAGEVERIVEVMRNENYLINYHNNCMWVMFHDDAESNDVIKSVLHSLRFHDLLTSQNADKEHDWDKYAQAMNESLQWTREKFPEFVASLDSKDWQSDSVYWNDSGVRVEWDRPQKTEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3Y0</accession>
    <name>A0A8H7Q3Y0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3Y0"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF86">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="80"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2184858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="481" mass="53753" checksum="0C31BC63D97966A9" modified="2022-01-19" version="1">MHQYAPITAHHPSLQCGKQVFGRHYSSLARQICQKAFPRRSSRLHPDDEKCSDIEIDDDEEDFSSVTSGSESSTTSGGIRGIQNLGNTCFMNSIIQALSNCSPVRDHCLQSSTRRRNSDAESTSIAVEFCRIMKELWLATQPPPTSSSIYRSSLVPISPLSLYDTVLKAITSFSPAEQQDAQEFFTYFLDRFYKTVPKKLPLAVNPSTEDTITTVVNDSNPAGLDELFRGLLLNKITCKDCGYTTRKEEPFFDLSLDLPEHSVMYSRRTRSQHKSNVCSLADCIKDFTKVTELDEFQCTKCQGKCTKQTFLMQLPQVLCLHIKRFGMVASKRPKACKLTAHVSFPVDGLDLESIGSDPANYELSAAVVHRGNTLSSGHYLTYGRNDGRWFRFDDNRATEVSRDTLADDEVYMLFYELVGSGSPPGSPSWSTSSQEFWSATSSPESDISSYAEASDEPSALVNKKRKTSVSTAPYIKRLRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4I8</accession>
    <name>A0A8H7Q4I8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Chromatin assembly factor 1 subunit A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_000822</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4I8"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021644">
        <property type="entry name" value="CAF-1_p150_acidic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022043">
        <property type="entry name" value="CAF1A_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272:SF0">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11600">
        <property type="entry name" value="CAF1A_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12253">
        <property type="entry name" value="CAF1A_dimeriz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromatin assembly factor 1 p150 subunit acidic region" evidence="8">
        <location>
            <begin position="310"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Chromatin assembly factor 1 subunit A dimerization" evidence="9">
        <location>
            <begin position="512"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="330"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="551"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="330"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="556"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2184909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="750" mass="85545" checksum="EE2AA2923BCE2706" modified="2022-01-19" version="1">MHNTDTTVLNSENSLVDEHTEESKDHVCESLENDAPSSGRADMAYGNDLHQAANQLQHLRMSDTAKHTLNRPETKKVIIKDGKIVYPEKKLRMNNHELVVNDMIVFRKFRATVSREAGTGSIVIPESFHTLIALLVQDSDEAITALSTRLNDTLSQFQADDSDYDEPEDEKRWIDALESTIKALASRERYGVSNDVLAGQTDVPNVVPAHLSIYRWEVKDIANFPGDIKHAIERRRRRRMSTIATGLFRTLTNEQQLQLLCAKRKKNSAPLPRINVFTTNSEVSFYAKENHPTIASNTLKISEEKPVDSNEQKKMEELRKIAEVKEVELEEKRKKKEEERKRREDDKRKKDEEKRKKDEERKMKEEEKKKREEEQQKKERSQLRLTSLFKTTIDDRSSSASEVQIESHTQQIFPPFHVKEYVQMASPAAFSCTLSDNFEEIIRGDYSFEGQDITPTVLLHDFKQSFRSELRKQRGVDHNIDLRTLLGHDPSMPLATAASLDGRDLRSLLKMKFLQFREDIRPAYWGTWTKSSKKISPRRPLDKDTEYLDYEHDSEAEWEPEEEGEDIKSGDEEDEDVDIADPDDAGWLVPEGYLSNDEGIGSDNEDEGLQSRTASRRNGPVKQVCIGVIYEDSTDEEDGLSPYSIQVLGPNTPINPFAVITNKQPAESEASGSLALATDKRAATIFPTEQTPVLIDAIKGKAEAMPKLIAEVKAMQGFEDVSKRQIEAKIKTIAVKEKRGTDARPIWYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4J0</accession>
    <name>A0A8H7Q4J0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_002420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4J0"/>
    <dbReference type="OrthoDB" id="2157641at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF373">
        <property type="entry name" value="PH AND SEC7 DOMAIN-CONTAINING PROTEIN C11E3.11C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="3">
        <location>
            <begin position="527"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="847"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2185982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1145" mass="126322" checksum="0EDD48AFC1032904" modified="2022-01-19" version="1">MLPNSRKIPTVPSNKSSHVDSSPALQDGQRSTTTSSHQPSAVPSKSGSFFSRFSRKRSKSATAPTTAQLPNPAASTSALTSKASTLPTINNHQPIDAKPYANHTPLKVQRKPIGSDNTIKSPQRHNTDLDPPKKLVMPEPVSSASLGSPKPTIVKKKSSAVSLDPLRKLSHKLEKTGLSSSLSSSKSTTNSPVVTKDTTTYSTPHSPVMTPPLSNSSSFNSDFLNTTPELKKSASMSRPLYQISEDKPESKPLVNRNNTSSGRSSPQTIPPIDAHETDLRALGVKEQDLKAVQESLDRLSSGGSAKRTDSSSSLYKTFETGKDSTRSSVNEAEVDNQSEPAEPLSLADIVLQNTRARLNTKVISDAEGRRLSRLEAYSVSKDQEASINGLAEEMVENDEIVTESDSDDDSDEGETTEEAFVDATGVSQDDIEREQAERRLSKRLSGGHYGSAGGLLLSIAGQQMDKKHRESSTPSFSSVEKALNELEFRTSVSDDMKLGLTDMNQRNKAVPPVPPSKDNIVRDMFIEPEIVIEDISTPASEISDVDSVSPSVDDALREEAETAAKKLWSEDANFVEKDLMTEWMGQPKPLNSLTLVYYMAMFDFSRMRLDTAFRRLCSKLYMKAESQQIDRILEVFAKRYWQCNKKSIFGSADVVYAVTYSLLLLNTDLHVVQGGHSRMTRSAFVRNTMSAAYAQGPGNDRHQGQQAKQFPKWWEAEMEIYLRELYYSIKQRQILQPKEHQLDNNRPKSILDTSGVSAFKRSVNSMVRLSSRESMILNTPDANQPSPRPSISSLHRPTSPPNMRRRQSATSLASAGSHGSSPRTPASPYQAMMSLPGQNASCTSQPPFYKEGLVIRKHLLESADQKAKTRDWKECVIVVNRGELQVYSSTSVGGENNPRRSMLRASSASLVNLADSLKTGVAPAQPSIFNGNAQLIESLSLNHSLSNALPPPGYNRQRPYVFALQLPNGGVYLFQAPSQEQVNEWVSTCNYWAARGSKEPLVGGVSNMEYGWGECLSDVILNLDAVENGDDDVGAACFTNPDQIVLYDWRPPVPPLVSCTLSETEQLASLQRQLATLTADINAHREIKKKIEVKFPVRSTNNIKALTNWENRSRYLLHEIIKLQNYCDILERAQAIYDKEKSEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4K1</accession>
    <name>A0A8H7Q4K1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Gamma-butyrobetaine dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_000470</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4K1"/>
    <dbReference type="OrthoDB" id="406634at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000001">
        <property type="entry name" value="Trimethyllysine dioxygenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF25">
        <property type="entry name" value="OXIDOREDUCTASE AIM17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="10">
        <location>
            <begin position="69"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="9">
        <location>
            <begin position="184"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2184561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="50612" checksum="C44C6CAD8E276CA3" modified="2022-01-19" version="1">MNLQIPLLTRHFTKIARQGVRPAILRAFSTANDQAQELLNGNANSVVQVGSDSVEISWPAIQPTDANMPHTSAYSHLWLRDNCPCPQCLHPSNRQKLHSSADIPLNISPENAILRDDGIEITWDKPLRHHHDSDKHRSFYPLSFLSKYSSPTARQTFRYNNMKYITWDRDLMHAENKFIHYDEYNTEEGLYKTLKQLFDYGIVFLDNVPTEDCKVTQVAERIGNIRESFYGRDFDVKSVAKSTNIAYTSLYLGFHMDLLYFEAPPGLQLLHSLQNTVTGGSSIFVDSFQAVEIMRKSHPEDYQALCEIPVTFHYVNDGHHMYYRRPTIVKDHNQEGGSWGMHVNYAPPFQGPLDIDDPKEAKRFYKAFQTFADIVEDEKLRFELTLKPGQLVIFANRRVLHGRTEFDPTSGDRHLKGTYLDMDVFKDKLRVLSEKHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4N3</accession>
    <name>A0A8H7Q4N3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_002320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4N3"/>
    <dbReference type="OrthoDB" id="2148442at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="17"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2185882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="358" mass="38678" checksum="27993A2097924898" modified="2022-01-19" version="1">MTLAQETNVNVVLRKQGEIVLEERPVPTIEPDQVLLNIKVTGICGSDVHYWLHGGIGDFKLKEPMVLGHESAGIVVAVGDKVNHLKVGDRVAVEPGVACRKCEECKTGRYNLCLEMRFAATPPIDGTLCNYYAHAADFCYKIPDNISLEEAACIEPLSVAIHAANRSKIRSGDRVFIFGAGPVGLLCAAMAKASGAGHVSMADISPQRLEFAKSYYTDSQIVLQRPDAGESNIEYSRRTSKAILETEEKADVVIDATGAETCVQMSLMLTKNGGCVVLVGMGSAVQNIPVQEISAREVDIRGIFRYCNTYPRAVKMISTGSIDVKPLITHSYPLKNAVDAFEHVKSGRDGAVKVVILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7J0</accession>
    <name>A0A8H7U7J0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_008316</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7J0"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000679">
        <property type="entry name" value="Thymidylate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="10">
        <location>
            <begin position="20"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2171590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="195" mass="21873" checksum="D51CDEE16EE03CB9" modified="2022-01-19" version="1">MPPFIPKLFNMAKRGALIVVEGCDRSGKSTQCAKLVEYLAANNMKAQLLKFPGKCLTHRTTSTGQMINSYLTNAAELNDQAVHLLFSANRWEAMDNMRALLLSGTTLVVDRYAYSGVAFTAAKGLDISWCRNPDIGLLTPDLVLFLDLPIESAERRGGFGEERYEKRDMQIKVRELFLQMQDPLWKASTAKTYDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7N2</accession>
    <name>A0A8H7U7N2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="10">DOHH</shortName>
            <ecNumber evidence="10">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LIA1</name>
        <name evidence="13" type="ORF">INT43_008195</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="10">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="10"/>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7N2"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000099">
        <property type="entry name" value="Deoxyhypusine hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="11">
        <location>
            <begin position="79"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2171815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="322" mass="35834" checksum="07E5892852A9CFE8" modified="2022-01-19" version="1">MTTVDTLQPTEAKYEEMESMLCNTSGSVPLSERFRILFTLKNIPNDRSVEIIGKALKDDSALLKHELAYVLGQTGNLTSIPILNEVLADAKEHEMVRHEAAEALGALGQLDSLPVLEQYLQDPSTAVAETCELSIAKIKYDNDPKNKEEREKNHSAYSSIDPAPPAVNTQSIPELEAEMTNTKLPLFERYRAMFALRDIGNTEAVESLAKGFNDNSALFRHEIAYVFGQMQHPASVPSLTEVLKRPNEVHMVRHEAAEALGSIATPEVFDLLKEFQTDQEIVVRDSVVVALDMAEYETSGELQYADGLQKDHHDNMHSLKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U972</accession>
    <name>A0A8H7U972_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_007630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U972"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF152">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="53"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="522"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2176976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="545" mass="62747" checksum="CDAA97FA2F283208" modified="2022-01-19" version="1">MQQRKPQRRHSSRSRDARPYARLPPNLRAKVRETSTMVKEYDTETGNKIINDYLILEEIGRGTYGKVKLAVDLRIDEFVAVKIVERHSRRKHLEMHRSSQDRSRDRSGLPTNQGNVLKIQREIAIWKRCFHPNVVKLIEVIDDPSSKKIYLSKLIISYPMIFLEHMEGGEVVWKDEDDQPTLPLDRSRAIFRDIVNGLDYLHYRGVIHRDIKPANLLVHNDGTVKISDFGVSYLQKPYVDGVEKAEDLERELSKTAGSPAFFAPELCYTGEQRDSMEETNFAGLTRSRSMRRTSSYSRPRITKAIDVWALGVTLYCLVFGGCPFVAETEFELFNIVPREDLKFPHDDVDDTLKDLLHRLLDKNPDTRITLDEVKRHPWVIEDVPNPEQWIKDTAPESYHDIGFEGDDIDVVPPSQPNRFMRKLIKLTSAFASFTGMKKNKDSSNNGNTRIPRTDLKYQSMVSLHSRKEKIKEQRYSTGAVENWNAGLVNANSRDPTTGPDHVGLAARLSDASEDDFPGFMEFTTRRADPRPELDTQYNSRKIPFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9R5</accession>
    <name>A0A8H7U9R5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_001475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000146">
        <property type="entry name" value="Putative two-component response regulator SSK1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1033"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="596"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="756"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1188"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="596"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="779"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="820"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="862"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="934"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1208"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1266"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2171998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1335" mass="144119" checksum="7D3143853680EABB" modified="2022-01-19" version="1">MDNEEPRTLSPEPLMSDSSKLTVEKPLLQALEQATDEIASFQDHHSANSQEHIPLNKANSQALLPHVAKLSALLRSLGSFEDEPFSNHAELEDFPDLINLSKLEHSNHQPDFSEMDKTITRASLFTCAVCFGNSLSAAVTSLSGNMTLASATYTAGWVALTSFWARSAIKMMKNKPQKTRLLSKAAKKSSVFTTIALGAHVALSHMFPNVVPPVRFSHSVVQVLCTCFWHFIYAVNKEKQAAVGSVEKINLDEQSTIKSSLQAYDDNRSTFLTTLANEIEDATVMLISTLHYFSPSRILEGSHELLTACSIPVPIASISAINTTTKQVRYISSNLPLLARMSLAQNIVEDTIERSTVQKEFDIGEMLQAVGDAMAGVAAKLDVKLVIYHSDNALHYTNVQGDEDVLRHTLINLVRNLLDSCTTGSCIELGLNVTPISSDNENEAPRLLVTFSMTLELSSNSESSLLPNANLTSKLLYYLGGSLALENIGETNTSFIIRLEMNQGTRTEKVRDVRERPHERLHRQLSNIRFSDEPTLDELSIFVNRLSGVKVVLYAPNQSIFAKHLTSCLAGWNVNISHVSVARPNDDDTYFRATDSEVTTPGSEVSAAQGSVGTNAELPTRPDVTSPQAEQTLLTAPAMFVLIDDDVYTLEQQLHEFRAQAALIANAHSSRRHKRGKSAAQANHTTAIIHFTALSEYKKVRDTINWFHTVSVLNPQGIPQVIVVPKPAGPRRFLTALHTAWSNAVVEPQYLPIATSPSSPMTPSSQKSIWNGGFPGSLPSPSHTSGVDDSGSSNESSTHAARRPTSAIYSPPIVPIPNDEGSNYFTAPGSSKVTSPSGIHAHEVQGSPTGVSTVEGVLFDPSNKSASLSVGSTPSARSSLNRYRSGSTSASAHATRRRSNTDLRGNLDGTSHISLPTGFHHPPMDQVSPGGSPLKQSTTASQGSPLDTPSPHTTTAKISHAVDPAFIPPEKNVIPATPSPSNVVVTEQNPMDAPAVAAIPPVIKPISEKSSAVSRRRRKEKVASSGVSSPPINVLIVEDNVINQAILSTWMKKHKIKFGTASNGQEALDKWNGGGYHLILMDIQLPVMDGIEATQRIRAIEKEQKTGKLTRPAVTDSQEGVSVFRSPVIIVALTASSLASDREAALSAGCNDFLTKPVDLVWLEKKIIEWGCMQALIDFDSWRKWKRSEATTTQKPSAPPPPPKTAEEPATATTTTSKPASPQPSRSSDTMATRKGVLLPGASGIKRRGSNVQDIKSGLPPRRTLTRASSDPQIQTSTPPKSNVSANTDTRTGSLSPIKESSGSSTDSTVKMMSEIAVNEALNAGSNQSNQQEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UC34</accession>
    <name>A0A8H7UC34_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_003899</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UC34"/>
    <dbReference type="OrthoDB" id="1112565at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF16">
        <property type="entry name" value="GH01042P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="385"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="448"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="512"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2180111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="585" mass="66208" checksum="02C6FCB9E40C73EC" modified="2022-01-19" version="1">MHKTSDPRISQILPTVTCSDCGLPVELRKLGEHVCSSAPPLPPLKAPAVPAKEDKLSLPFLEKYSKMTGKAMTSLRTAAAAAPSLSEGLYKSVTSRTGTYNNSGSNESMHVDTPLSTSPQNIAADPKKSYIPESHDRRPSIASSASSGTRRNNSGDDNSSSNRYFKDTRGIDPILEDEDNYNPTPSRSARTERHDDFYGHKPLSNSMSTSRKKGPFFLGNLSQENINQTRKNSYSSYRRSDDDDFYALEDESSPSNTNYGFLRHDTSPSRSSSGDEVNSPRTPGSISYKEESGFYNSRFNINDTRAEPKPSGVRRPSMKNKPDTDVLDSMMADLMKDVSGDFDPCHRECLSCTLCRAELGDRTPYFEFEHQLYCERDYNVVRRRVICTACEHPIASNAKSIKALGGQYHVGHLRCHHCREPVDKDTTGIVEHKGRVFCKYDFKELYLPKCTACKKPVEREAVSAADGKLKGKWHRECFGCHTCRRPFPNNTFYVFESLPYCKRHYHRLNNSLCRQCDEPIEGPCAQTAEGWRFHPPCFTCQVCRCAITDVYYMLENQIYCEVHIGHMQRKKNMRAEKRRTQFGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCX5</accession>
    <name>A0A8H7UCX5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008563</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCX5"/>
    <dbReference type="OrthoDB" id="2257454at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013219">
        <property type="entry name" value="Ribosomal_mS33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08293">
        <property type="entry name" value="MRP-S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2180981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="105" mass="11842" checksum="8F8FBACF962E655C" modified="2022-01-19" version="1">MSTPPSPARLAKLTQTVCKIFDTVYNPTAVRSGNKILRERLVGPSVSSYYPQPLIHFRDIKAAVPQLKLIDMDEKERLDEIARRKRRGKGAPKKGQGKRASIKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDF6</accession>
    <name>A0A8H7UDF6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-methylacyl-CoA racemase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDF6"/>
    <dbReference type="OrthoDB" id="16747at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1540.10:FF:000004">
        <property type="entry name" value="Probable alpha-methylacyl-CoA racemase mcr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF5">
        <property type="entry name" value="ALPHA-METHYLACYL-COA RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2175419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="48051" checksum="7A0A22A209576C72" modified="2022-01-19" version="1">MPVLSRFRLSTCHLKLWRMDDESKSFGVDSELQYKVLVYLNGPRDFTTQALLTLSFTTSTMQLPLKGIKVVELSGLAPAPFAGMILADYGATVIRVDRPVNFNPDVLARHKRSVALDLKQPVAIKTLKMMLKSADVLLDPYRPGVLEHLGLGPDVLLKLNPRLIVARLSGYGQTGEWSKVAGHDINYLAISGVLSLIGRHGENPFFPVNIIGDFAGGGLMCVTGILMAIIERERSGKGQIVDANLTDGSSYLASFPYYMKKNGFSWTEERGKNMLDGGAHFYEVYRTKDDKFMAVGAIEPQFYTALIEGLGLSESELPQQMDTAHWEEMKDKFRSLFSAKTQAEWVQIFQNTDACVTPVLEYNAEDDNVKGFANTPKPAPLLSRTPALDSSNVSGVLEPGLHTTEVLKEFGLTETEIQALIKKRVVKANDIKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDH8</accession>
    <name>A0A8H7UDH8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial distribution and morphology protein 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_001802</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MDM31/MDM32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDH8"/>
    <dbReference type="OrthoDB" id="17678at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012571">
        <property type="entry name" value="Mdm31/Mdm32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068:SF0">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08118">
        <property type="entry name" value="MDM31_MDM32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2178955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="761" mass="86824" checksum="2C29F61C9BB9849F" modified="2022-01-19" version="1">MKAALSRSRKQLLARSLSPGFFAYNANTTGYHEAVTNAPTVSNLKQAIESFESTLSNRNLETDATHNLGNHFRSARCPQRTWQACTQAYAISSLKTTQRQHLSTMKPMLMERSLHVERIPLLLRRTDNLRLLQRYYSSMPHLPHRPTKAEVLAQARGFFERLRVRIRFILMRSMRPWTLNDIGAVFSWVFLGQTVWLLVGTTSFVSLILWTANSLQFQEWIAYRIGQYLTSATGAIVTFDSAIVPNWKEGKITFTNVRISRMPRSERAKFERKSVLQDEDEYKLQTSAGSPISTGALESIARLTNSSEPDSFDDNPLAGVHFDEDEKNSEALRKWMWFDLTIESIEVTLNLVRWLDGKGLVQDADVQGVRGVVDRRHVRWDTKVPYDPAAARQKYTPGDFELEKLTVDDLLVTVYQPYGFRPFPVSIFNAELNRFRKQWLFYDMLSATSIVGSFDKCLFSVHTPQLEKSVLEQSSHIDSPSKYRSHDIYHYYPRSNTDGVVVGDESERFGVINEHAMEERGYKRMSRLRIDGVNTDHIFRRVEGPPGWISSGQVDVSADIYIPTEATTADSTELLRKLVYEIADKIELPQPVVLGTGNGEDEIVIGAHKTEDRQKEKAHIDAEPQFVMDIDFRFKNTKANIPLQTPELGYLSNAMVRPIVAYINRSKSIVPIKCRVVLPLSNFDGAWTAYDSQLIGSISEQLGKGFVDLTVDQQERNRRLKRIGFWSLQEITRNLVSLHELMKGTSRGFWSFLGSTSSYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UE44</accession>
    <name>A0A8H7UE44_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_007246</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UE44"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000007">
        <property type="entry name" value="Thioredoxin-dependent thiol peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF4">
        <property type="entry name" value="AHPC_TSA FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="11">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2182316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="156" mass="17283" checksum="A0DE7840491F3BFC" modified="2022-01-19" version="1">MSHPLLNKAAPKNFTLLNQKAEKVDLAEIIGIKSTVLFFYPKDNTAGCTKEVCQFRDQFDVLTKHGATVLGVSSDSVDSHKEFAAKQRLQFDILSDENQELRKAYQVPKSMLGLLPGRVTFVISKDGTVKEVFNSQLDTSGHVKAAIKTLDAENKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEK5</accession>
    <name>A0A8H7UEK5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_003883</name>
        <name evidence="7" type="ORF">INT43_006706</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEK5"/>
    <dbReference type="OrthoDB" id="10263513at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2180095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2183695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="109" mass="12177" checksum="DF39F252DEC9D964" modified="2022-01-19" version="1" fragment="single">AKKDAAAKPTSSSGGKKAKKKWSAKKVKDKANNMVVLDKQTYERVFKEVPTYKFISQSVLVDRLRLNGSLARVAIRELEEQGAIRRISRHASQVIYTRATGGDDEKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEP8</accession>
    <name>A0A8H7UEP8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycolipid transfer protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEP8"/>
    <dbReference type="OrthoDB" id="205255at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="68"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2180230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="244" mass="27469" checksum="36EB16AC076CD856" modified="2022-01-19" version="1">MEIDNANQKLLSGGGSCIMYKIKTPPRYIKHLDRGAWCFTLLATYKPIMTFFDTLSRSYADVDTSNGIDTDQFLEASTGLVKMFDLLGSSAFSVVQSDMNGNIKKIRDRYLTNPTANNTLQNLCANEAGEKKRTATEGLLWLTRGLDFTAQALRRSLDNPSEELNVSFTKSYENTLRKFHSFVVRPVFGLAMKACPYRKDFLEKLGGDNETTKSQMEAWLSALEKIVAEINALFQSHPQYIKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFM3</accession>
    <name>A0A8H7UFM3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFM3"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524:SF1">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2181250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="196" mass="21937" checksum="784A6A10E547CBF4" modified="2022-01-19" version="1">MSGSDKQKNRNSSQMRNRALPGTSQQQAQNQFTPSLEPIPGPARDRSAKGQNKQQSKVMLGMPDIPIDEDNDNDAYATKIGGKPIWLKKNQYPQNSVQYCGCCKGSMYLIFQGYAPLENSIYHRTMYVWACNRRLCIKQPGSIKAIRAHQVDPEYLKQQKKKAAAKLRKEAQIKAAKKRNAFVGTANGSKFQVGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFQ4</accession>
    <name>A0A8H7UFQ4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003461</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFQ4"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04435">
        <property type="entry name" value="DEP_fRom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF2">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="555"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="777"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="936"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="276"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="444"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2178208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1256" mass="141270" checksum="58B610554E3FBE64" modified="2022-01-19" version="1">MGTTSNSTNNAHNRDDVPASQQDMQPRTQTYSLFRIPSTSTRSPSSPRPTGVNGQSENKPGANSATPGRFSQVARLNASNADSSTTMSASATIRDLYYQSQKAQDVNAEVERPSYQTQQEVVAKNRIHRKYDENSSIYDLSTLHDDDSDDSDENDFVYRSTATFMQFKEATPSLYSLSDAGSVFSLRTIYNDIDESKSATQTSTILGNTERPRVEDMRSVSPIPSRSSNMIAKRAMEPKIVVQKEERRPTSLSGSSSSNLLSRLSKSTAPARAKLFNTTPARTSHLRAGSASLTVPSKAPFEIPRHAGPRPRVISDVSEHSLEISRLKEKSKPLHLQHHRGRSEDNIPIVNPALLSRVAIAFKDRVTLGTKVKDGIEYTDAFDGTEAVDKLAYIIKTSDRNLALLLGRALDAQKFFHDVNYERRLKDSLFEVYQFKELMSTSLSQENQVQDSNNEDDDVDKPESASVSSETDSELPTGVFTLLTDCYSPTCTRERLCYSIACPRRLEQQARANLSLSSVLERSVSKSSLSEENERLWTNTVSKEIANTISKQERKRQETIYELIYTEKDFVKDLEYLEDFWIKPLLESDIIDAAYRETFVVDVFWNIAEILSVNGALLDDLEKRQAERPVVDRIGDILLSHVDNFEPFVQYGAHQVFGKFAFETEKSRNKMFTSFVTTVERQKESRKLELNGYLTKPTTRLGRYNLLLREILKNTPEGHPDSIAIPKAIATIKTYLSKVNAETGKAENRFNLMLLKERLVSKDAAQFNLELEDEQRQLISKGQLKKKGTGSESADLHVFLLDHYLLITKQKHIQKAEKYKLYRPPIPLQLLSVSLPDAAAKRVSSILPSTGPARNLAGAIKSQSTSDLSSMAMKTSYPIVFSHLGREGAAPVTLYCSTSASRRQWVDKVEKQRQTLTREQTVFRLVNINSRFFSGMNRVRCVSILSDGTFVFGADQGVYVQRSTSKGTPTRVIALDRVSQIHILEESRLILVLSDKTLYTYSIEALMAGDTAPKRGRRVSKHVSFFKVGHTNDRTLVCVVKSSAITSTIRTLEPVATNDPKKSKSNFGRLIRGSSEALKIYKDLYIPGEATSLHIFRSNICVGCDRGFEMVNLSSMRNQSVLDPSDEALAFVFQRENMKPISMFKLQDGEFLLCYNQIAFYVDKKGRRSRKNWVIEWEGHPLSFALRYPYLVSFDTTFIEVRHVDTGALLQVIPGANIRCLNPESSGPIHCVSDNNGSLESIFELELESRKDQKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGB6</accession>
    <name>A0A8H7UGB6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">calcium/calmodulin-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_001699</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGB6"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000449">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="26"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2178853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="346" mass="39258" checksum="E44521FEB4F5C115" modified="2022-01-19" version="1">MGFRDSISAIVHNKKQPDSYDKKKEYTITKVLGNGTFGNVRMANRISDGQPVAIKSIPKKNVAGHFEVVYREMTVLQGLQHPNITTFYDWFESRATGGELFDRICERGKFTEKDAVATMKAVLKGVEYLHSHQVVHRDLKPENLLFKSEDQDAELTICDFGIAKHLTDESAVLTTVCGSPGYVAPEILLRKGYGKPVDLWSLGVITYTLLCGYQPFRAQDRAELLDEIIHARYEFHDRYWHNISSEAKDFINRLLSIDPRKRPTATEALNHHWMTTDAALDQDLLEQVRENFNPRQKLRSAIRSVQALQRMRTGATAHRLSMKLTEQSINEEKIPQNASSSPAAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHH7</accession>
    <name>A0A8H7UHH7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_002459</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHH7"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054295">
        <property type="entry name" value="CHS4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF16">
        <property type="entry name" value="CHITIN SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1032"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1060"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1086"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase 4-like" evidence="12">
        <location>
            <begin position="347"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="522"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="551"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2186021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1171" mass="131311" checksum="CA366142FD6FEB9A" modified="2022-01-19" version="1">MPGSSEQAERGLLSDDVTAGSEDHIATSDDNTTRDTHANESETVKDTELEPPTKPLPSIPHTPTKGNGQSVTIVEDIEQEKYPHTESSRQVVRRSKSLSRPERHRPRTSAERRRLEMAAIGRGDYASADLFRTEEKQRRSVASHMVSDSYAGKHKCPGCWTLTSWIATWWALPVMLKSFGLHDRQMQQAWREKVTLVFIIVGLCVAVGFLTFGFNVTVCGREAARIRPAGVQNDQIVISGRVFDVTSYQHPSNPNVPESGNLQDPPLSAGGKDLSFMFQAVNQNCKGIFKPLKADDDKGNVVNYFPCVPLDRYAPSMNGTENANNVGCHVSKTARTGLKDLTLVGDVYYNWTDIQKSKTSLVAFNGNVLDLSRLRYLVPNVPLPTQLAQFAGPGNPFIGHDATYWLSTTADRLQLGKCMQDVLKVGVLDNRSTGCIISDVVLWISLAVILSVVFIRFFLALIFGWVLSWKLGSIREETSEERRKRREAVLQWEMENNDDMHYPRSRSVVSFAHMNNTNQLNNVPNESSLSMVRPVGTPYSATPKTRRRFLPTTSRFTQPTSTPPLSRNSSPYNPPLSSRFNPAASRGSYQRSSEGSVNFGSQHFGSSYLGSQTAGSQYFGSQHLGPPTREMLDNQMADLQAQTNYNFNFDLIHTFMVVTCYSEGEDGLRTTLDSLANTDYPTSHKMLLVICDGLITGSGNGMSTPDIVLSMMKDFIVPVDQVQPSSYVAIADGTKRHNMAKVYSGYYRYNDDEEKGIVVEPENQQRVPMIAIVKCGSPEEATDKKPGNRGKRDSQVILMNAMQKVYYAERMTQLEYQFCKAIVKLSGQHPSRFEICLMVDADTKVYPDSLARMVACMSRDPRIMGLCGETKIANKADTWVTAIQVFEYYISHHMSKAFEAIFGGVTCLPGCFCMYRIIAPKNGQYVPIICSSDITEMYSENVVDTLHKKNLLLLGEDRYLTTLMLRTFPKRKMMFVPQAVCKTVVPDTFGVLLSQRRRWINSTVHNLLELVLIRDLCGTFCFSMQFVVFMELVGTVVLPAAISFTLYLIVISFFVTPVPVIPLLLLAAILGLPAVLIALTTRKMVYVGWMLVYLFSLPIWNFVLPCYAYWHFDDFSWGETRRVDGEAKGEDHGGKKGKFDGSQIQMHHFDAWARLERKLAAETRQATLPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHI6</accession>
    <name>A0A8H7UHI6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_006295</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHI6"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF50">
        <property type="entry name" value="BIFUNCTIONAL ALBAFLAVENONE MONOOXYGENASE_TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2183290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="62452" checksum="BAC9441DF3ED4B5A" modified="2022-01-19" version="1">MTSLSLQRLTAEVLKNVNNISGFYAQHVLPYLAKQRKASYIASAAVLFICYQVYQFAHIPKKLKHIPAVPFWAYMRSVLSGEGPDKRLNLIYSVLSDSPSGVFLKPHRVGWTVGAVGPQALKTVWIRKDDYPKSQSLIEDKRFLFAKMLGVHNILGLNGAEWKKHRMIANPAFHRHMPVKLFGKLCERMMSRFEIEEIGLSSVDISALMQRFTLDVIGLAGFGYDFQSIENPDNQKVMAYNSVMDGLKDPFFFFFPFFEKHMLWAFSSRREQHLNCESLHTTYQNIIENKKRVLLEQKGRQEDPEKDLLTLMLEAGEDDPSQALTDEELRENLSVFFIAGHDTTSNALSFALYWLAVNPDIQEKARSEVIKVIGDGADVFYPTENQISQLKYIYMIMKETDTSFLQTLRLCPPVLSSQLRHTEEDIELAGTVIPKGVHIQAEIFVAHHDPSVWKDPEQFRPERFAAGGENEENARKGLAWSPFGNGARQCIGMNFSLAEQRVVLSMLLRKYTWTLPKDSIHKGHPVFVGGSSLLLSAQDLHLSFKNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHX9</accession>
    <name>A0A8H7UHX9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHX9"/>
    <dbReference type="OrthoDB" id="3044029at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034492559" evidence="2">
        <location>
            <begin position="20"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2183725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="481" mass="51412" checksum="01897B2AE96FEA10" modified="2022-01-19" version="1">MRVSLSVLALVASVALTSALPVDSFNAYHEDAAHVTTTATTTKAATTTKKATTTTKKVTSTKTSSSPTSHPTAPFGREISVKSTADFCLFLPPTPGADVATTEDFGVLYCAKGTAGAPGAKTFPSGFITTSHFAKSSSYIQVTGYLDRTKYKLKASDEGGQYDNHGNGKPTGAQCKGYNYFVSLIEPANNRFCIRCCQNKVDCNTGRSGYGCERVVPGDYSQSSSHSNTDYASVLDEISYGHINAIEPTNNNTANTPLLAFPPEITKLETLSEDETVEQFKAEWTSFVSQLKTSYPNSVSDIEALDNATENITDVEGWHQFIALLKTKVDGYLYPGESSDDDTDNNTAPAAAPATNENDASVWHEDDITPPTDNTATSDDTDGSDSTSDADNDTADTDPPTTSNDEEVNNGTNSTGTVSDSFDDYVTVQDLDTELNSKFDAFESKLLDEIKSIINNQGSSATTDDSTVSPSDSTHNNQATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UI00</accession>
    <name>A0A8H7UI00_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_003582</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UI00"/>
    <dbReference type="OrthoDB" id="249612at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019335">
        <property type="entry name" value="COG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21443">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21443:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10191">
        <property type="entry name" value="COG7"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="504"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="575"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2179799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="962" mass="107925" checksum="00AEF8037339D94B" modified="2022-01-19" version="1">MAEHSATSDIPNVDHFSKADFEVKNWINLTLKSLAAEKKTDSVHSVHLEERTNVMVTRLQLHGSQISHKVKTTTEDVMQSIPLVLYDLQLMRNQVDSIKAGIETVRRDMSDEDTGNRSAVQRLRQLGLVKSRMEDCRTALRETENWSNLEQETRSTIQAGDFAKAAGQLASAQKSINVFQNTPDYERRKELLNQLQDELSNAIRPQLDLALKEHDAVTCHNLYNVCSQIALPEVYLDAYFEYCQIPIVQLWESAHLKEDQAGSKDSLKDFLSNFFKEAFIHISEEYNWCRSVFPDPREAMQAFIQNLFLNLNPSLSDRVASAQSYYGSDGLAHVADVFQITESFGLSLERLFSKSVVAAAENEPSGHRRSGSISARRKSQQILAIPLALRTSAHSEQEGWAYVLYDPFLQWQSQFTEQQKKILESVATALVHKLESSQGGGIDISHISSFRTSDAFEAARQAIDVCVKLTHGFGAAGLLKDLNDYFSNLTNKLIALVNKLNQDDDNKIDSAENNNNTVSMSDDEDELGSMQDQGDWSKFQNGLRLLAICKAMSQELMSLELRIQNSLETVKDIVEDKDHDDSPESSSPKSTRPPSIGPFSATTPTREQKRASIGHDNNTSKLVRRESASFRQHLVSEHSKTRFPKASISLLRSSALNNFELARLMSNISAIAEEESEKESSNGHIRLLATAQQAITQFTLACQHFVFDVVLRPVTDNFDKIMGMADIWTANSEEEGYGKRAVDDVELPQFSQAPSEYMTRIGEQLLILPQQLEVYADDEVLSFMIDELPFLSKSKSTASDRDIESKAEAIDQVNVEFDNTGENLEDTTYDESTYQNEDTEAPALPPIADVSTSVNEDLMAEEVLQKWTLAICHGAMQSLVHHITSDIRSLSPQGSQQLRVDIEYMVNVLSALDVRPSPSIIQLHMLLGLSDSELSQRLKDGNQEDKVLQRVAKVRGIELLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIG5</accession>
    <name>A0A8H7UIG5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DSBA-like thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIG5"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF2">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="29"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="219"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="428" mass="47974" checksum="81C77205852B0847" modified="2022-01-19" version="1">MQRGQSSFMLIYGAMIDTPVLLGGIYQATKAPQDVMNPAKQRISQGTLARTLDKFKVPFNFHPNHPVRTVNALRLLYAVEQSHREKLTDALYHAYWVENADISQEETLLSIVKSLSIPFEASSAIFKDEKHQNALREATSRVVELGAPGVPFFQVSKDDNDKNGAVFWGQDRVLFVETAIKALQAGLDPMDWEKVPNIVDVLESKLKTPSPHVGKGKKVTFYYDFASPWSYLGYTQLYRFKALGCDIDYRPVVVGALFKSIGGPNMPMAAMSDSLRRMQLQDLQNWTLFWKAVMKQSGMEAGKVDKAMQVNWPDKFPIRSIVALRVGLLEPATTDCIYQASWVDNVDVSDNEQLKKILNDNGFDGEKLLQQVADNKDEVKETLFANTKMAIDAGCCGVPSYQVDGDRVLFGQDQYHFIEDLLNGGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIQ8</accession>
    <name>A0A8H7UIQ8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HpcH/HpaI aldolase/citrate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_006221</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIQ8"/>
    <dbReference type="OrthoDB" id="1773at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308:SF0">
        <property type="entry name" value="HPCH_HPAI ALDOLASE_CITRATE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308">
        <property type="entry name" value="LYASE BETA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="87"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2183217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="386" mass="42405" checksum="604648B0647A0D45" modified="2022-01-19" version="1">MTVALRSLSLLARSAEPQLLRSKTVGVVTRPSLLRSSVLSTVRLLNTATAPEAKNGVSSKLSENRPRRALFYGKSIGVYVNELPILVPGSDERKLHKSISVGADCIVYDLEDSVAASKKGSARQMIMDALEASEHGKAEKAVRINAVGSGLELDDLNVVLHTKRLQAIVIPKVQSARDIQFVSRMIDSVAPESNSRPNIRLIASVESAMGIMNLREIATADPRLDALIFAAEDYCADLSLIRTPQRTEMLYARQKIVTTACAYGLQAIDLVCVDYQNMDILKEECREGREFGFSGKQAIHPGQIEVIQEYFLPDPKDVERAVKIMDGYEHYAKKGVGAFVVDGKMIDMPVIKWAQKVVAKAKAGGMELPEFGEKETTDKNKNTKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIT0</accession>
    <name>A0A8H7UIT0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="14">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">INT43_006297</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="14"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIT0"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="18">
        <location>
            <begin position="140"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="38"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG2183292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="487" mass="55106" checksum="02FC2FB8173C0A5B" modified="2022-01-19" version="1">MPPSFFKRHKKKLIGAAALAALAVIIIPSAVIGTRNNNSATSQSHGNNGNSTIDNDPDAFDDSKQVNANTPPLNQKFKYGEEPIRGVNLGGWLVLEPFITPSIFEQFDPSEGVIDEWTLCEKLGPDEAKKQLQDHYETWVTEDDFKKIADMGINHVRIPTGHWAVNPVEGEPFVPNLAFQYLVRGVQWARKYGLRVMVELHTAPGSQNGWNHSGRVGEIRWMSGPNGTHNANLTMNTVLPMVDYFSKPEWSNVVTMFGVLNEPAIYKMEEDEVKQWYLDTYYSIRNITGEGKGPLLTYHEGFIGLTKWKGFMPNTTFDRTVLETHTYMIFDQGLVSMSQQKQSEYPCKEWKADLEQSGNDFGQTMVGEFSAATNDCAKYLNGIGVGKRYDGTFKEGTPAVCPNCTCNGTEDWQTWTDDYKNFLRQFIERQMDAFESNIGWYFWNFKTENHANPHWDYLLGVEQGWIPTDAGNRSFSCAQITNDGDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIV2</accession>
    <name>A0A8H7UIV2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_000658</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIV2"/>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000002">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2184745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="239" mass="26321" checksum="96C4233D25F12BC3" modified="2022-01-19" version="1">MSAIALIKTAAVSSARMATVQKAAPTLSWAVMSRRAYATDNNGENSTEAPKPASEEATEKKTEGGKTAEELTATLAEKEKKLAEIQDAYLRCLADQENLRVRTRKEITQTQEFAIQKFAKDLLDTVDVLGMALNSVPENLRSKEEAAKHDLEKVADQLSNLYTGVSMTETELLKILKRHGVERYSPEGEVFDPNLHQALFQAPMPDKEAGTVFSVQKAGFMLKDRVLRPAQVGVVAEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJ71</accession>
    <name>A0A8H7UJ71_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="13">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">INT43_006723</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="13"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJ71"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000020">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034401837" description="DNA-directed RNA polymerase subunit beta" evidence="14">
        <location>
            <begin position="25"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="18">
        <location>
            <begin position="77"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="225"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="481"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="582"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="664"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="15">
        <location>
            <begin position="711"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="1085"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAG2183712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1174" mass="131800" checksum="AEDEF74D2475777D" modified="2022-01-19" version="1" fragment="single">CKARNSWHLYLFSGWKLLVSMVAATKSSKQENDHVHGKKDGFEPLLNETYEGKHLSDPVPEIQDKWKLLPAFLKVKGLVKQHIDSFNYFVNVDLKKIVKANERVTSDVDPHFFLKYSNIRIGVPERQDADGVNRSVTPHECRLRDLTYSANICVDIEYVRGRTIVRRRDVVIGRLPIMLRSQQCVLTGKSEAALAKLTECPLDPGGYFVVKGVEKVILVQEQLSKNRIIVEVDKKGNVMANVQSSTHERKSKTAIIVKHDRIYLKHNSVSEDVPIVVAMKAMGVQSDKEIAQLICGNDHDLLDLFAINIEEASKLKIYTQKQALDFIGSKVKVNRKISAPRRPWADEALEVLATVVLAHIPVENLNFREKSIYAAMMVRRVLQAMNNDVEVDDRDYVGNKRLELAGQLLSLLFEDLFKKFNSDLKLNIDKVLKKVNRTQEFDVYNQLILHGDHITSGFIRAISTGNWVLKRFKMDRAGITQVLSRLSYISALGMMTRITSQFEKTRKVSGPRALQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDNEEGPIKNLVFVLGVEDVNMLTGAELYQPSVYVVFLNGSILGVTRRAQQFVANFRRMRRAGRVSEFVSVFINEHQRTVNLSSDGGRICRPLIIVENMQPRVKQHHINDLISEKLAFEDFLTMGLVEYLDVNEESDSNIATYERDVIPETTHLEIEPFTILGAVAGLIPYPHHNQSPRNTYQCAMGKQAIGAIAYNQLNRIDTLLYLMVYPQQPMVKTKTIELIGYDKLPAGQNATVAVMSYSGYDIEDALVLNKAGLDRGFGRCQVMRKYATMVKKYPNGTFDRLADPPQKDSDAYNPTYDALDADGIASPAEPLETGSIYINKQVPSNTNVDMGVANGIQNVTYKSAPMRYKSPQTGYVDKVLLTTTESDQTLIKVLVRQTRRPELGDKFSSRHGQKGVCGIIVQQEDMPFTDLGVTPDIIMNPHGFPSRMTVGKMIELLAGKAGVLAGKLQYGTAFGGSKVEDMSKILIENGFNYSGKDYVTSGITGEPLSAYIFFGPIYYQKLKHMVMDKMHARARGPRATLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEIHVCEECGMIGYAGWCQYCKSSKKMKSMQIPYAAKLLFQELLSMNICTRLMLDDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJ99</accession>
    <name>A0A8H7UJ99_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJ99"/>
    <dbReference type="OrthoDB" id="3360032at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019433">
        <property type="entry name" value="GPI_ManTrfase_II_coact_Pga1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35465">
        <property type="entry name" value="CAVEOLIN-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35465:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10333">
        <property type="entry name" value="Pga1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2181029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="267" mass="30658" checksum="BC6CAC3E625DA1B0" modified="2022-01-19" version="1">MANSILYAEFSQLMMRTFFYQAVLIAVVWANTEKIIFHGSKEIESTHDPHNYHHVNSWAERKAWPTLLAPYASHPDSIRPRSALDEGPNPINAEDPHYEFQNEIPFQRWYRLQGIESDGGYEARISYPATSPTDFKIMLLNYTQVYNILSDPILHGSSNSAEFQDFLESDNDLDLKDLRDKEYALYLFVEGNYTGVSTVEGVEFRPVKYNLALEQLHLGFIPNQAYKLAISLLLVVGLGVCFVVPGFWKHIMDTISEDVSVERKKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJD4</accession>
    <name>A0A8H7UJD4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_008716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJD4"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2181134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="78" mass="8952" checksum="AFCC5284F6515A38" modified="2022-01-19" version="1">MPVAQAEHHKGLGNKYFAEHDYRLAIQEYSTAIIKDASQVTYFTNRALCYSKLERYNEAIQDCRRAIELDSHTGEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJF8</accession>
    <name>A0A8H7UJF8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">diphosphoinositol-polyphosphate diphosphatase</fullName>
            <ecNumber evidence="1">3.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_006959</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:79699"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:79700"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:56312"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:140372"/>
            <dbReference type="ChEBI" id="CHEBI:140374"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:56313"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:22385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>6-diphospho-1D-myo-inositol pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:79703"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:230534"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:79704"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Atypical dual-specificity phosphatase Siw14-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.52" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJF8"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052840">
        <property type="term" value="F:inositol diphosphate tetrakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14528">
        <property type="entry name" value="PFA-DSP_Siw14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000024">
        <property type="entry name" value="probable tyrosine-protein phosphatase At1g05000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020428">
        <property type="entry name" value="PFA-DSPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF48">
        <property type="entry name" value="INOSITOL PHOSPHATASE SIW14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01911">
        <property type="entry name" value="PFDSPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="62"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2182033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="231" mass="26665" checksum="AB6D40ABC1E3A402" modified="2022-01-19" version="1">MAESAIDIDIKAQEQAILSATRATARPQHSITVSNPPWSALDDLLGDEEEEVFEEALIPPENFNMVSEYIYRSSFPKKKHFTFLKKLGLKSVLTLILEEYPAQNMKFLEENNIKFLQFGIAGNKEPFVQIPEEKISAALAAMLDRRNHPMLIHCNKGKHRTGCLIGCLRKLQHWSYTSIFDEYRRFSHPKSRSMDQQFIELFDTRQVWELIDKEHMPNWPILGKFSANPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJP0</accession>
    <name>A0A8H7UJP0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Alpha-galactosidase</fullName>
            <ecNumber evidence="5 13">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_007200</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="5 13"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJP0"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000177">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF91">
        <property type="entry name" value="ALPHA-GALACTOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0430">Lectin</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034142791" description="Alpha-galactosidase" evidence="14">
        <location>
            <begin position="23"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="15">
        <location>
            <begin position="410"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2182273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="524" mass="57167" checksum="69AA09B8D1CE0F3D" modified="2022-01-19" version="1">MHPQKVFGTSLSLLATTQLSSAILQPTPPMGFNDWARFMCNINQTVFTDAVDAMVSTGLRDVGYKLVTIDDCWPEHKRTANGSLTWNTTLFPNGLEWLSDYIHKNDMLFGIYEDAGTETCGGWPGSYGHEETDAKTFASWKVDYLKLDGCNVDSVPGQSDEETYKQIYHKWHTILPELQISFSESAPAYFVSDKSLSDWYKVMDWVPSNGQLARHSYDIATWGSGDVWDSVMTNYGYNIRLPRVQKKGFYNDPDFIIAGDSNLTLTEQKSQFALWSSFSAPLILSSNIPALTKDQLAFLMNKDLIALDQDELVQQATLVSQDSTFDILSKTLANGDRALTILNKGSSAATATVPFSKVGFSSAKSCKYSVKDLWTGETSSLSKQVVAQNIPSHGTAVYRITPSGQCKTITPGGQIFNTFTMDCLSAGSSVTSTKCGATNAEFFSISKNGTISASLAGGNCLTANGSKVTMETCTSAPQQVWSHNIQGYLINKASSNCLTAKNGTSISVAKCGDELDSQVFEIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UK69</accession>
    <name>A0A8H7UK69_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_006854</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM U1 A/B'' family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UK69"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12247">
        <property type="entry name" value="RRM2_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000029">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="77"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="221"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="174"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2181929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="295" mass="31943" checksum="34287A1B4485F0E5" modified="2022-01-19" version="1">MAQQGMPPPFPGIAPPGAPPMGAPPMGGPPMGGPPMGGPPMGGPPMGVPPQAMGIPPPKLVGGIPTPRQPPNTTPSRTVYVNNINEKVQIPVLKKTLETLFQQYGKVLDVTAYSNIRARGQAFVAFEEEDSATKAIKELQHFVLYDKPLVLQYARQKSDVHAKLDGNYDEHHAARVEEKSKRPPLSAPLGPRPGMPGTGFPPGAHLPPGHQIPDEFLPPNNILFLQNLPEDIQQAQLMDLFQTYPGFREVRMIPTKRDIAFVEYEDETLAAAAKSALGGHEIEDGKPMKVTFARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKC7</accession>
    <name>A0A8H7UKC7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_007006</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKC7"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03199">
        <property type="entry name" value="DHHC_PAT_PFA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033682">
        <property type="entry name" value="PFA4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="110"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="458"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2182079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="490" mass="56208" checksum="97DDBDF99E519269" modified="2022-01-19" version="1" fragment="single">PFTGPDVQSLFCHPQMRVELSGRFFIGGVLTLISTIAYSSQIFVFYSALGGWSWSTLKVLGPLNVIVAMIFYNYYLACSTDPGKVPHNWEPPAAISQPSEEAKRQGITAPRFCKTCNVFKPPRSHHCSECRRCVLKMDHHCPWINNCVGYDNYGHFVRFVIYVDLATIYVLALMVWRIRSIMDDIRHFRFQAEPSTTEIVFLVIDLVLDIVVLMCVGVLSVYHIYCTARNQSTIEGWERSKVKTLIQRGKIPPTNYPFSVGIVKNIKSVLGNNPLLWLWPQKMPSDGLHFPVCNGIDPRAAYVWPPRDPDDLRPSIFSRPHQLPPTAHNGKPRKPRYYIEQNQRQHIRRDSEGFLVREITAEERTNMIDSYVAPDDLEIYEMGPQISDEYMGHEDEYYDSGSAMTDSGDDIDFNEDEESMRRAVNDYDYASGHYEDDTHWQEYVAADYAGRNDIVYDGEDDDHYFDEDNDDTPLAKLIPKAPAKGSKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKQ4</accession>
    <name>A0A8H7UKQ4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_007369</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKQ4"/>
    <dbReference type="OrthoDB" id="10263032at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1040:FF:000003">
        <property type="entry name" value="N-terminal acetyltransferase A, auxiliary subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021183">
        <property type="entry name" value="NatA_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF2">
        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12569">
        <property type="entry name" value="NatA_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000422">
        <property type="entry name" value="N-terminal-AcTrfase-A_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="596"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="609"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2182439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="747" mass="85990" checksum="74224DE42B350D51" modified="2022-01-19" version="1">MNAKRELPAKENAIFKNILRNYEHKQYKKGLKLADTILKKFPEHGETLAMKGLFLNNLEKKEEGYEFVKKGLRYDLTSHICWHVFGLLYRSDKNYEEAAKCYTHALKYNKNDMQILRDFALLQTQMRHYDALIETRTQMLQQKPTNPPFWVGLAIAYQLVGKYDLAIQTLEAHESALREMPVNFEHSELLMYHNRLLEEKGDIQAALEHLNTIEPKVCDKRALKEKRAQFLLKLNRSEEAEKAYRQLISENPDSYAYIRGLIAVKGFDSGMKEDLSLHDLTAEQQSTMLGIFDDIQKDYPRSNAARNLPLNYAKGENFRNRADVYMQTALRKGVPSLFVDIKRLYTNAEKERIVEELVTGYAKSLEENGHFNEDGTQAIEPPTAYLWTLYFLAQHYDKQRKTDLALQTIDKAIEHTPTLVELYMTKGRILKHGGKIEAAARVMNEARELDLQDRFINSKSAKYYIRDDKIAEAEKILGLFTRPDAASPLQDLTDMQCMWFALEEGDSYQRQGKLGKALKRYHTVDKFFADYFDDQFDFHTYCLRKTTLRSYIDSLQFEDNLKSSAYYIRAANGAVKAYMTLADIPKTANGMDEANMTEAEKKKARNKARKAELKAQKDKENKPPKKEQVKEEAAPKKADVKKPTDEDPDGEKYLKTQDPLASALEWIHPLEQLAPKVIDTHLLGFEVYLRKGSLLLALKALVNSHKIDKNNGQVAKNVTRFKEAVKAHPPTNEDVKAVIESQLATIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UL52</accession>
    <name>A0A8H7UL52_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_002219</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UL52"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01377">
        <property type="entry name" value="MYSc_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000002">
        <property type="entry name" value="Myosin heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="12">
        <location>
            <begin position="38"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="11">
        <location>
            <begin position="93"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="8">
        <location>
            <begin position="665"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1150"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="851"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1152"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="186"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2185782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1239" mass="143486" checksum="E0502A4ED021AA4A" modified="2022-01-19" version="1">MTQGPSLRGSYIDSHGTKVFLKSHSERSQDAVAQAAFNEKRWVWVEDPEEAYIAGDILRELDGGQSFEVALSSGPVRIVRANEIHKMNPPKFDRVEDVAELSFLNEPSVVHNFKMRYLHNDIYTYSGLFLVAINPYKRLPIYTEEVIKMYKGRKRGEAPPHIFATADQAYYDMLQDQENQSILITGESGAGKTENTKIVIQYLASIAGEGRSTNKSANRLEQQILQANPILEAFGNAQTIRNNNSSRFGKFIRIEFNMQGQIAGANIEWYLLEKSRVHQQSPKERNYHIFYQLMHADAATRGINPPFSPAKLLLDSDIGKYNYIRKSNRIIDGVDDEIEYNKLKKSMDIMGFDEKEQFDFFRIVAAILHIGNIKVLAERDRADIRDFAVIERVCHLLGVPAQEFRKCLLTPRIKAGRDWVNLARTQAQVVSSLEALAKALYERSFSSLVGRINKAIDRNLSGDKLGFIGVLDIAGFEIFEVNSFEQLCINYTNEKLQQFFNHTMFEIEQEEYRKENIDWSYIDFGLDLQPTIDLIEKIKPVGILACLEEECVAPRGTDQRFLEKLNRTWDGVESKYQSTRFQDGFVIQHYAADVQYSTKGWLDKNKDPLNEDVTRLLAQSSESYVATLFEDYLEEDEEETLPSLAKLRKGGGSFRTVGQRHKQQLLSLMKTLRLTHPHFVRCIVPNVHKRAGDMDIPLVCDQLRCNGVLEGIRICRKGYPNRLPFAAFRQRYEMLCPDVLGNGFVDGRTACQTLLKCMELEPEKYRIGTSKVFFKATVLAEIEETRDRKLSSIFTNIQAICRGRIARNRMNKKARRTEALKIIQRNSRIYVNLREWPWWRLYSRIKPLLGVHNMESQLKLKEKTIVELKQQITTQETELHDAGRKQRDLEAEKREYVHLLEQERMVAQDTAASLSSNQEKLTLVEEELQDKAAKLQKFENEMAKQQDLLQAAQDLNEEKQSQLQQLEDRLAQEEEERISAQTQLKEMSRNLSRLERDVEEKVEANSKLSAENSAQLAMISKLHNELKDTDEENQSLGERVDVLEENEVAKDRRIKELEQNEEVKDRKIKELEDEVQALIEQAADTTEKDLEIAEVKNQLDVFMRKEEDTRRNELEERALLRKQFEKSKEEFEGKLENMTQKAKTLEQALTSRNDEKQNLEKQLEDKTSNEKQLQSQIRELQSALEKQQQDNQELRNNNDELEDEMSAMVELLRAEKEEATARLSRLGLHMERPRLLRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UN00</accession>
    <name>A0A8H7UN00_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_002158</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UN00"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF65">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="84"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2185723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="553" mass="62938" checksum="7E120031B9C5470B" modified="2022-01-19" version="1">MSSGESSPTTLKSHSVFESTNEKKDVEVADIEEIGLEESVFDDPNLAQYYQPREDYEGYHRFDPKAVWTAKEEKAIVRKIDFRIMFWCCIMFVALQLDRGNISNALTDDFLPELGLTTNDYNTGQTIFYICFLLMELPSQLISKKLGPDNWIPIQMTLWSVVAMSQSRITGKSSFFATRALLGALEGGFIPDIVLYLSYFYKGEELPVRLSYFWVSLTSTTILGSFLAYGILHLRGANGWSGWRFLFLIEGAFTLIIGIVSFFYLPPSPTQTKGWLRGKNGWFSEREEVIMVNRVLRDDPSKGDMNNRTAVGPRDLWRSLCDYDNWGLYIIGLLAYVPTGPPAVYLTLTLKNLGFGTFNSNLLTIPSSILFILNVGIVGLLIDNIGLTYLSRWTKERSLTSMLAVVWALPFLIALEVLPGDINQWVKYAIVSLLVAYPYCHPILVGWNSINSNTVRTRTVSAAIYNMMVQLGSIIYSNIYRANDAPLYRQGNKVLIGICVFDIFLFIGVKRYYIWRNKTRAAIWDAMTTDQKSEYLATTTDRGNKRLDFRFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCN7</accession>
    <name>A0A8H7PCN7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_009098</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCN7"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051965">
        <property type="entry name" value="ChromReg_NeuronalGeneExpr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040:SF3">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="183"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="183"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="149"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="253"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="360"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="360"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2171437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="451" mass="50030" checksum="DD5D70C5C57A19A3" modified="2022-01-19" version="1">MSLPSNTSTQPSSQLDTQRVKDLLGRCGLNQYYERFAAEGFDQLKSVRTYVWHWLMAPTTRLIIYIYNYLQLFDITEADLSALNVKRGHRRLLQREIASRKGIPVDQPLLVESQFSPKEHQSPLTSTSTSGYSSMASFHTNHDPSISLECSSSISSTEEDTSSSSPLQKRKYRRHAKPDKHAPIKPPSAYVMFSNDVRKELKDYNMSFTELARIVGNRWKNIDVELKEKYEDAANMAKDDYLREMSEYQKTDEYKQDAAARAVGRPRKRAKTESPSSGSIADSSSNGNGNGNGNGNSLSSNGNSSNGGSSGFYNNGYSTNGTSQSSISSGTTPKFFTSKAAADGRLSTARLAAQDAYYNRMSSQPSPNNGSQARSVDTNPDTPTAASSHAGSEEPVFRSLRTVVPEPHLQQLQSDVRSDDYDSAESGRSQFSDELPSTPRMRRHKSFHLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCR4</accession>
    <name>A0A8H7PCR4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_009156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCR4"/>
    <dbReference type="OrthoDB" id="2313712at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2171495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="210" mass="23006" checksum="BDC6D29B00317941" modified="2022-01-19" version="1">MVSNTLKHLRWDCSCCRTKYVFPPTVSDEIPATPPNSAVDDRTDFFIAAYGLSNLNLGGGATPGTPAYELERPELYFSSTPTFCYVSARFNNFNCTRCQTYNEAVTPADQQVSFYAICSQKCLDKAVNTQTSPISLGASFRCKGCNATQIPSVRVIPINDAKAKKSLDAKLKGKASRLLALRNEGRVSAKTRFDHSLIKTRPVVSRSATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCT5</accession>
    <name>A0A8H7PCT5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_009144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCT5"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034998393" evidence="1">
        <location>
            <begin position="24"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="178" mass="18981" checksum="DE17B47D0BECE7A4" modified="2022-01-19" version="1">MPHRWASLASAFVLAAAGSDSNAATEQSSEVGYTGLSDLLYPVPCLKDSFAFWVSKVASKGTGNSLTQEGLIQVDNGLLSLLGEIGIAPSTPPPQPQLVHASVIHQTNGSGYPLIRVYSRIPHPYFVQPLHNMATPMAVNARILCGLSKNVLPNVTMRYVLGTTHGYLFPASDWPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCX8</accession>
    <name>A0A8H7PCX8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_008338</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCX8"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="292"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2171612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="707" mass="79223" checksum="F89BFD9DF71B7889" modified="2022-01-19" version="1">MPPEENCVFKNPIKKRGPSKESLEDRLHKVEAMLSSLTETSPELQSMQEDTESIEGHSYGSPDSGKTFTDMPIGNESYFPAVPASTDLILTKKYSGFAAVAKSPSKSMEDSSRGLENLCVVDHYGYIRYYGSASGLSLFKKASYFRDRSFNVQDGREKIAYLELEKKKDPERSPLVAMPPPDLAQDLIDLYFEHCYPLLPILHKASFLEKLKSKTNQPSPLLLNAIFAVTSRFSDDERVKSASGSPYDNGSVFFDRAKELLDKDLDKVNLATVQAIILMSTHQYGVKKGNRAWLYNGMAFRMAQSMGLFRDCDHWNIPATEREERKRTFWCCFIVDQVTSTHYGRPTTLNEDDCDTTYPSEEDDISNGSAPVVEYMRCAIDLYKIMGRVMKHIYPATPKGLLSKSADQVVGALHDDLNHWHSNLPPSMRYNSLQEHGTHSDTRPPLALCQLHMCFYTVKIMLHRPHMLKVESQPVVSFPSLEICTSSAYAILNIIDDLASEKRLRFIGHYFIECMLAAGGTFIFLASSSSARGRDEAKMAIKKLLNAFETLDGNWAAATRYKKLFVVAATNDSREADKTDLSNGKKLWKGKAVLTQKTSSYSHDEAASLASDYDTPSNNIPDASVVDTPVNIFSTTDTAMDYPVESQYNGQKSPLITDTATVPLGMGSLNASYVESHGLYDPHVLQNMQDFTTQFLDFPTLEELFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PE21</accession>
    <name>A0A8H7PE21_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PE21"/>
    <dbReference type="OrthoDB" id="2280493at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="139" mass="15172" checksum="33CDFDC550195FB6" modified="2022-01-19" version="1">MEKSLDDYDKSLEALDKEKEKLEMLMRRMGQEWAESGAGIGWMGSLDGLTSPAEQSTTDTSPDLDGNSEFLISPPISDYVQSLLNANQQAQISINDATVLESSQPLTEIIAPPMSTTKRSSLIVKTPFKLSDSPPPPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PE77</accession>
    <name>A0A8H7PE77_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_004831</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PE77"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05574">
        <property type="entry name" value="STKc_phototropin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="105"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2172289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="790" mass="89361" checksum="815DF73993D7266C" modified="2022-01-19" version="1">MLRSLKASFTGSQREEVSKTSTSVTNDRTSIDLSYNKSSLSELPRSYSELDLSSVPPFHNKEAQYFSRRFQASEQKNVSVSTGEWRSYAGSNGRCRPSNVAPSDFMNIGMLGRGDVGHVYLVRKHGASNLMAMKVLSKKDMIQRKKIDRALMEQKILLRLNHPFLVTLHETFQTDTHLYFCMDYCSGGEFFKALQSLPGKRLCEADALFYTAEVVLALEYLHLMGFIYRDLKPENVLLRDSGHIVLSDFDLAKHDAFGHPTLQKGLFRKGDHFYDQVPRLNTRSCVQTLRTNSFVGTEEYIAPEIVLGQHHGSEVDWWTLGIFIYEMLVSNFPFQYATTPFKGSSRNKTFQNILTGSVWFPEAIILPSSPKAQSLPPKLSSGCKSLIRTLLNKDPRGRLGYRAGAGDVRAHKWFKDINFALIRNTKPPLKPECCEIFECSPGKSLEWLKEKKRKQPNLSGDSTDPFDQFCSVTTWMFWLLLSITHLGLSRYLFILFTKPQQWHKSWMLNDPEEKTILWVAENVKSQKKEELYDRVRNADLVLVWSHGGAITFGMAAQNMDLFVRIIKLLKEKSNLNTVVCAVEYRLAPEHPFPAQFEDTTAAYSHLIRKMNVDPKKVIMGGDSAGSLLMPDTIIYNQLYGTILGTSDSLPTPSGYIFSSPVTSTLPNCASEKENRKTDFCPIGVDWVSAYLNSVPKGMNPAPWAFLKETKLAEHSARRVLVIVGGHEIRRDENLLVAETFKNAGVQTTIIQEDYPHNWFCLGDTIVGDPAVMEKANANFALWISQTLTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PED5</accession>
    <name>A0A8H7PED5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_004922</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PED5"/>
    <dbReference type="OrthoDB" id="532630at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977:SF1">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2172380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="90" mass="10336" checksum="3802E4D79E1E059C" modified="2022-01-19" version="1">MHPPLATHKHQGCEDIIQALDECHSSGLLNKYSGKCNDIKLKLNECLGEEFQIQRAENKQKAAAKREKIRQVWKEMEEPPAGFYDNQQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFZ5</accession>
    <name>A0A8H7PFZ5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_004626</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFZ5"/>
    <dbReference type="OrthoDB" id="79171at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="4">
        <location>
            <begin position="81"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2173252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="238" mass="26298" checksum="C55A9CF41243FB4F" modified="2022-01-19" version="1">MASADELADYRYQIEQIEASLESDPQNSELLKLKSDLEELISLTSQFETVQSSPATPTKKTEVKQKEEEKPASSAVPLYQQYSVGQEVMAKYQADGKYYKAKVSNVGGSGVVYSVIFSGYQDVEIVKAEDIKPIDNKNKNKRPAGMFQESSDKKAAPVKKPKKTAAVEVKKNAWLNFANKSEKKKKISATPINKKSMFKTPDNPEGKVGVIGSGRGMTGFQQRGKHQYSTDGNNAEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PG39</accession>
    <name>A0A8H7PG39_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sds3-like-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_004627</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PG39"/>
    <dbReference type="OrthoDB" id="70376at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="16"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="331"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2173253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="48007" checksum="B6525E34B9833153" modified="2022-01-19" version="1">MLPQFGYVFAQAGADRNSHNLPLAPPIHQYSNEPPSQKYQQQQQHQQQPPPPPHGPEFTPPPSMGFRDSQREDPYYEHMPSSYSAQHPPAPPPPTSSYPPYTQVDPYQSHVEGYRGSEPPYHNHVSMKVYNQMDEPVYRYEEEQRWHADSENYQHPYHDQRQAYAQDWSDDGMDIVESRLSRKVREYSERIAWLDKDFDDAKEDIYRDRLRNLQEELQAIQDEFAQLNIIMFIGTHSAFLEVVRDLEEMRDKAIADAKAFGDYQYQCVQRQYELDSEAVEEEYQYEKQNLHDMMLAAIAEKKKQIVDDRDDIGERSSDLVRDTSYRASSKRNLRKRTAAGLDLPDRRSNGYSSRGDTPRRRAAADRSGTPLRLEAPISNKEEDELENEYMQLKVKRKIGVLHLDMAQSTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGH4</accession>
    <name>A0A8H7PGH4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGH4"/>
    <dbReference type="OrthoDB" id="2360820at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2173260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="387" mass="44073" checksum="BEC30C353EB16941" modified="2022-01-19" version="1">MYTFQQAADAARICMQEIVERGLDERKILLKTEQSSFLLNKFMKEKVCSGHDLRYESIHRVATLMKDILWLCPERIISRKAWRSINYQTCMIENLASIMTENAMTFLLELMDFLLMLMSHKSCNLMTARRLGEAMGKVTFGPRDCNPMMAERCSNLVTKLLIERSRKSSNGLGNVNVLSPDRTASPVIAERSARLASKKSFERIAQKANDWSNNLAGVLDLFESDCQQHNQDDLQYVSIFSTELSPAEIANGDPTLVRMVRNINENCIVEPCQESICSDDDHSYEYSETIVNDLEITDLPSIDTLSKAQPYPQPHKVPSKRFTWSLGERLSSKQSFVKDSRKSKDFSEKSKARPKSLITGVNRQITRIRSLKNLSFVSSSSRDLPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGM9</accession>
    <name>A0A8H7PGM9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homoserine kinase</fullName>
            <ecNumber evidence="3">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_004673</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Commits homoserine to the threonine biosynthesis pathway by catalyzing its O-phosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGM9"/>
    <dbReference type="OrthoDB" id="195231at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000068">
        <property type="entry name" value="Homoserine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF1">
        <property type="entry name" value="HOMOSERINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861">
        <property type="entry name" value="HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00958">
        <property type="entry name" value="HOMSERKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="13">
        <location>
            <begin position="72"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="14">
        <location>
            <begin position="262"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2173299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="355" mass="38169" checksum="4C0D67106B1CCC2F" modified="2022-01-19" version="1">MSNLNTPRKFRIKAPCSTANIGPGFDVLGISLSLYLTLDVEILDGSQGDVKDFEMTYTGEGADDVPLIPEKNLITKTALYVLAANEIKSFPKPLKIHVHNPIPLGRGLGSSGAAVVAGVALGNALGQLDMDKDRMLDYCLMIERHPDNVAAALMGGFVASYLRELDAADTEIASIPASETFETVTNGSGPAPPQPPKGIGHFVQLNWAKEIKCIAIVPRFEVATAKARAVLPTSYERQDIVFNLQRLAVLTTALGRSPPDADLIYNAMQDKIHQPYRKTLIPGLPDVLSSITPQKYDGLLGICLSGAGPTILALATHNFDNIAKEAMAVFKHIGGFDCFYEVLDVVEDGTTCTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGR3</accession>
    <name>A0A8H7PGR3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NTF2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_005086</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGR3"/>
    <dbReference type="OrthoDB" id="25872at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040736">
        <property type="entry name" value="Mex67_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057125">
        <property type="entry name" value="NXF1/2/3/5-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24048">
        <property type="entry name" value="LRR_NXF1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18444">
        <property type="entry name" value="RRM_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03943">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="9">
        <location>
            <begin position="376"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="TAP-C" evidence="10">
        <location>
            <begin position="699"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="577"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="577"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="621"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="662"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2173666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="744" mass="81605" checksum="5054BF8F6EBAE45C" modified="2022-01-19" version="1">MEIRGRGRGGNSSITSRLSGYNDSSNNSYGDNNNQNYNYNNTQGGGGGYRGRGGRGGNRGRGGRGGGRGGGYNYDGDVQMNPNANSGGGNVEIIVSNYPPGSEHALVEFLKRKSKRQWEPLQTQPLDDGLHLLVQDMNTATAVTRLNGFQFMQNNLSVIVLGDTPTSAPTQHGHQSNRQQSAPVSSLDTLSQFLQQRWSADQRFLNLEKMGLDPLYKRLMHSSSNDFRPALFKLAAETFGDVTTVSLTSNRLRNLQPIAALAEYLPNILNLSLQDNNITNFTDLEPLAGKFNHLNELVLDGNPIKAREVERHGSDITYRSEVTRRFPTLKLLDGVPVAQAIQFDIQAADLEATTKQVQLPARVKGSFFDQDSSRMAANDFLGTFFQTFDGNRSALFNLYDDTALFSVSVSTTFNASKSRNKGGAFNQGHHNQGPPSDWRDISRNLTRNKSLKRRVECLYYGSSAIVQLISTMPPTVHDLSRADNFVTDAWQMSGFSGYPAVLFIKVHGEFREGTAPNSAKYSFDRVFIVGPAGPGSRAQNAGWQYVILSDQWHIRNHSGNRAFQPEPEQPAAPAFGAVQQAPPSFSQPPQQQHIPQQPFGHPQQLSPAQPQAQTFGHQPSFAQPTPQHQAPFAAPPIQQQSQSFSPAPSSYTPPIQPVSQPFTPPSAQPTPPPPVAPPPTPQSSTPVPPSAERPPGLTDQQHMQVMELKQRSGLNYNFALQCLAENDWNSANAMDSYERLKVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGY1</accession>
    <name>A0A8H7PGY1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_005197</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGY1"/>
    <dbReference type="OrthoDB" id="8093034at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF5">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="9"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="132"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="239"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2173777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="375" mass="41217" checksum="D957EEDB28D6A692" modified="2022-01-19" version="1">MAADDQQTRTIYVGNLDSRSVHAPNALATVTLFNISFAASNNTALPPTFALTLVETTDLAGACPICPPRKHTTFQYGQQPALSYGFVEYTESAAADKAINEFNGKKIFNHELKVNWAQGPNTGEKQDTSNHFHLFVGDLAPEINNEALSAAFGAFGTLTDAHVMWDQLSGKSRGFGFVVFKEKADAEKALAAMNGQWLGSRAIRCNWANQKGQTATPAPIPGQVLPIETVVNQTPDYVTTVYVGNLPPTLTQEEIAPIFGQFGIVQEIKLQAERGFAFVKLDSHQGAANAIVQLQGANIGGRPTKLSWGKNRENWANYPMGAYQNQVRHRAPNPSYRGQQNWNTMNDYQKMNLPETSPGARMNSQRFGNWPEQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PH06</accession>
    <name>A0A8H7PH06_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PH06"/>
    <dbReference type="OrthoDB" id="2324139at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034712355" evidence="1">
        <location>
            <begin position="20"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="271" mass="29588" checksum="B3FAA268CA8B6FA9" modified="2022-01-19" version="1">MKLSIGVTALAALAAVVGACERDCRLGVAHDFAGVYHGAIAHTLQLLKPELTQISVHDALPSQISAAVSEDALRAGIEAGVSSSIDKMISATTGETLDKLYYAELFNPNFAKDVFKGDCNAPLPETGKPRLTRKVPDPPGSSWTLEECEKMDYICGNPPSICHFLPQVKERLLNQTRVRLSQYSAVNGVFHHTLDTDVRNSIVSVLSREGAGSLVDDPIVDDMMNTIITKQLIGLSNWSKRDVQNLCRSSDQDILCNSWDAEIKKKILVWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PI45</accession>
    <name>A0A8H7PI45_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_004291</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PI45"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="121"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="376"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2174268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="432" mass="49579" checksum="F8C88EFE67166547" modified="2022-01-19" version="1">MASSIDASPHSQPQSPASPQPSPSPLIHPYDHSKIASDCQVILHPPSPPSPDSQKPPVQFNSQSPQSLYHPLPSPTQQQNTLSSYHEQEIQRQQEESSKWHYWHTLPSPYVRKPSFGLNHIELLDTLGTGTFGRVYLARLKDSQKYYAMKVLKKQEVVRLKQVEHINSEKQILAFVKFPFIVNLYCTFQDDRNLFMMLEYVVGGELFSHLRRAGRFTTDIARFYASEILLAVEYLHSKDIIYRDLKPENLLLDHKGHIKITDFGFAKTVVDRTWTLCGTPEYLAPEIIQSKGHGKAVDWWAMGILIFEMLAGYPPFYDNNSFGIYEKILAGRVMFPAHFDPYAKDLLKRLLVGDRSRRLGNLKGGAEDVKRHKWFRDVDWFGLLEKKVQAPIIPPYRHPGDTSNFEKYPNAIDVDHSRIPTGDPYASLFPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIV6</accession>
    <name>A0A8H7PIV6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Plasma membrane ATPase</fullName>
            <ecNumber evidence="13">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_005854</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="13"/>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIV6"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000042">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000211">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="663"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="689"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="721"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="759"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="790"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="824"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="30"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2174792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="936" mass="103133" checksum="0A00438B7E5D5849" modified="2022-01-19" version="1">MGSEIEEKNPQVAPDDEKVGNVQLEEQAHHEHEDEISPELEALIQTDPSKGLTASEYEERLARFGKNELPEKKKNPLWKFLGYFTGPISYLIEIACIIAGVVGDWIDFGIILALLFINAFIGFFEEAKAESALDALRQTLALKTRAWRDGKLIEIDVVELVPGDVIVLRLGDIVPADARLLGIGVTGEATEGDLQIDQSALTGESLPVSKKKGNTVYSSSIVKQGQQLAVVTKTGADTFIGRAANLIAITADEGHFQKIISKIGNVLIWSTVVLVVIVLIYQLVKFRGTPDGNWKVVLENCLVLTVAAIPVGLPTVMSVTMAIGAKQLAAKKVIVKRLTAVEELASVSVLCSDKTGTLTLNELTFDEPYLSPGFTADDILLYSYLAAEPGANDPIELAVRRAAEGSLEVLKNRESQHDVPGYKVTSFLPFNPTTKMTQATVANLETKDVFKVAKGAPQVIIKLVGGDDDAVRAVNALARRGLRALGVARTVPGQLEKYQLVGMISLLDPPRPDSGNTIRECNAFGVDVKMVTGDQLIIAKEVAARLGMGRVILDANHLVDPSKSEAEVTEHCERADGFAQVIPEHKYRVVELLQKKGLLIGMTGDGVNDAPALKKANVGIAVHGCTDAARSAADIVLLAPGLSTIIDGIKTSRAIFQRLRSYALYRITSTIHFLMFMFIITLAEDWNMPAVLLIMICVLNDAATLVISVDNTQISDRPDKWRIGQLLTLSVILAIMLAGLSFAHWFIANNVFHVSTNELHSIMYLHISSAPHFVIFSTRVPGYWWENMPHWIFATCIIATQIVALFFSVYGIFGEGEHVAPCGWPWGITVLAISLVYFMILDVVWMKFLFYFDFWSDEFSVKVFVFRRWNFALTARLFPTPARKAKLRQRIDEREKHLAIKKSWHKVYHVVEAHRIASAFQKLGKEQHGPEVPTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIY6</accession>
    <name>A0A8H7PIY6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_005776</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIY6"/>
    <dbReference type="OrthoDB" id="10029326at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051704">
        <property type="entry name" value="FAD_aromatic-hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865:SF2">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="17"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2174718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="421" mass="47330" checksum="86A5E2FDF424F36B" modified="2022-01-19" version="1">MAHWKTPTDLLPMSPLKVLICGGGCAGPALASWLARSGHHVTIVERFPALRASGAQIDLRAQGIEVVKRMGLLDTVRSKVVYQAGISIVDEQNRNIATIMANRSGKGAQTFTSEYEIMRGDLVRILYDATKDNVEFIFGKTVEHFKQYDDRVEVQFSDGRTDSFDLLVGADGQASRIRKEILPPDAPEPYNRLGIYLAYWFMPRTERDSNMGKRYHSLGSRVVMSRSHSVTETQGCFAIKDDSEELMSLSKAPVEQQKEFWAHKFSDAGWDTARFIEGMKASDYFYCQEVLQVKSDTWYKNRVVLLGDAGYCPSPFTGMGTTASFVGAYVLAGEINRNSQNIPQALANYDRVLRPFVDELQVLNRPLIRLTFPQSQLGISILHFIAGTICYLRIPELVARFSKEDKGGWQLPDYIELQQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJ11</accession>
    <name>A0A8H7PJ11_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_006021</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJ11"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="38"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2174959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="148" mass="17142" checksum="0A380DD40C9058DA" modified="2022-01-19" version="1">MSLITVNDPNYDRLERRLNQVFDHFFNDLGWSRKANQENSSAITPAIDISETDKNWVVHAELPGVKKEEIKLEYHGNAMVISGESKRSEEYEKENVRYQERRYGSFSRSVPLPENVDKTKINAKFENGVLEVLIPKSEESTPRKIEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJ27</accession>
    <name>A0A8H7PJ27_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_006051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJ27"/>
    <dbReference type="OrthoDB" id="8883818at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01786">
        <property type="entry name" value="RA_STE50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12573">
        <property type="entry name" value="AT09986P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12573:SF4">
        <property type="entry name" value="AT09986P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="7"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="3">
        <location>
            <begin position="220"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2174989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="517" mass="56938" checksum="E74B2ACE2B63F16E" modified="2022-01-19" version="1">MDSVLNWDEVKVCKWLSSVGYTGYEKKFKENGITGDVLVNLDSEALKDLSIQSAGVRTALLKNIYHLKVLYRIPINDWDYIPPTITYENEWLGHNGMLDYRKIEAAFQERDATVRQLTDEISKTINDVARLRDEMMSMWKVIKDKKPLPVPDFEKAKPTNSKYPNPWSPHNLRAMSPYESNQEGWPQSPLEASNSMRRIMHDGATFDEIQRGQQPVTVNDGGAIKVYGGRIANNSKVELEASKNVRLLLDDPCSKVIPVALKKYNVADDWQNYALCIQWGPEDNLQERVLSYEEKPLRVLQKLKESKQNPMFTLKHIKDSKPLTPPGGDSNMAALTSPNLSPPAGMLGRSQSYKAATSMSNPNSFSPSRPVPLKPSSSVSSNLHQHKDLPTSPNDWSVNGTSAAGSASGQSTTQSTLRSLMGPLTKSNKSSSQSQIDASAKSGSGNHLAPKSNLEAPVMAPSISAPTASTSTNTSQAKPEHFLGDLGLESGMADAIYSYMMSRSENNSKDSNGNDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJ57</accession>
    <name>A0A8H7PJ57_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_006111</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2175049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJ57"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034789787" description="Galactose oxidase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2175049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="60723" checksum="8221D8D6D9008C6E" modified="2022-01-19" version="1">MKYPQYRLALFAAWSLIIPYVRASLSPSPRWGQAASIVNNRFCFQGGKTGSLGVNETTAINTNDLLLLNSIHTITTQSAPWALGPADGPTTCYHSAIPGGENNHHLIIYGGQTAGGSENDSSTSTLYYYDSVSESWTKPNIDSPPRRIEHTMVANLNTGIGYLFGGYPLTNELWSFDTNAMTWQQFSNQTFTPSPRYHHTATLLADGRMILIGGFDGNKTINMNDTYVFDTNALEWSLLNATGKIPTSRRDHAATLLPDGQSILIHGGTDKNYGVFMSDIAVLNCTLPDACVWQTLPNLNPPVGRYAHTASLIGFTAKETGDSNIYIYDLTKSVWANSYQPATSSIDSTSTFMTIATATASATTSPPVIPSTPVQTAIASDASPGTKAGAAIGGVAGVAALGALIFVFYHRRSKGRQAEGAYGTKRNSHYAGDRFSIISQSSAGGRGNRLSALFLGRNSAEPQRFSYHAGQSSRPVTMYGDYYRANRMSAISQPAASHPHTNRFSYAAGNVGTINETPGDLIGVDIGNSYFMPRRELFVVNGDADSKQSSRPPSEMSDVQYKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJN6</accession>
    <name>A0A8H7PJN6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear pore protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_005812</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the nucleoporin interacting component (NIC) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJN6"/>
    <dbReference type="OrthoDB" id="1918363at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007231">
        <property type="entry name" value="Nucleoporin_int_Nup93/Nic96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04097">
        <property type="entry name" value="Nic96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="4" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2174754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="422" mass="47833" checksum="A4EC827699F0C1A9" modified="2022-01-19" version="1">MPITLKQLFEKSQLLTTSVNESELPYIERRLDQIESQSKNLLNQSSKESQKPQDINSRAHFLLANAGINTHQLVNDLDAIQLDKALSPVAPLYSTDVEGFLKQVHQESVISALEDSQYLPGCEQVNLLLQQHTENGANDSHKANTDNDMQGVSEDKWKLPTYTKGTNLLAAIRKRNLEAMKAKGGDKKDGEMKGVEEKSKTATDTKPLATSSPANVWQLIDRLLEANPDANNTANVEQNSALLKSYKTFLEEHAQKIRRLDNAKTGGTYYIDHLNNCRADVALEFVGRNEALFKTEPQFIYYLQEYLADANHIPSKHTRSTILESYRRLCYSTEGADPYKMALFKILGRCELYKKNLPEVTPSIEDYLWLQLSLVREISNSMDPSTDAYTLNDLQQLLKKFEPQFRSRSNPSISQTSPFIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJZ3</accession>
    <name>A0A8H7PJZ3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_001059</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJZ3"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="140"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="488"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="711"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2175412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="746" mass="83923" checksum="62B2690B62EEE2A1" modified="2022-01-19" version="1">MQTFSKPVAETVASALAQRKAQLASAAVVSFAGALLVNSRRRQAAADQKKNDLHLHSRNEAVERVLLPFSQQSIQKPPKTLLAITSQETIRQHKRFFKPVDTLQKVGVNKEFIRQLKAIAKIIMPSFKTKEFLLIVLHSIFLVLRTWLSVVVARLDGRIVKNLVAANGRAFALSLVEWFAIAIPATYTNSMIRYLQSKLSIGFRTRLTRYVHDLYLDDKNAFYRIINLDNRIQGADQFITTDIAKFCDTLASLYSNLAKPLLDTVIFNYQLTKSIGMAGMVGLFVNYMVTARLLRAVTPSFGKLAAIEAKLEGDFRGAHTRLITNAEEIAFYNGADLEHSILEKTYMRLIKHINSIYKIRITYNMFEDFLIKYVWSAFGLGMCAIPVFLPEWAGTVIPVKAGDSPESSRTRGFITNKRLMISLSDAGGRMMYSYKELAELAGYTSRVYNLLSVLHSLHANEFQSSENPDAQYSLDNIQGKIIANYNGIEFKQAPIVTPAPGNERGGEMLVKDLNVSVKPGEHLLITGPNGVGKTAVARVISGLWPLFSGCLAKPGTDDIFYIPQRPYLSIGSLRDQVIYPHSHEDMLREGRTDKELLEILNVVHLAYIPDREGGWETKKEWKDVFSGGEKQRIGMARMFYHQPKFAVLDECTSAVSTDVEGLMYNHAKDTGITLITISHRPALFRYHQHLLRLTGDHGAWEMETIGTKEQQLSLEKEIQALQGQLKEVETMRTRLQAIDTELSLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PK81</accession>
    <name>A0A8H7PK81_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_006071</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2175009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PK81"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="99"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2175009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="186" mass="20283" checksum="0F42E8503057F427" modified="2022-01-19" version="1">MLSSPYSKNASFATGQPLDSSQMSSSSSATQGSSAGSMAASKRGAAQRANSSPYRQPTSRTSRKQQRKSESDEGASTSSSKPRAGRGKKPPHELLSEAEKKANHIASEQKRRQNIRVGFDQLVEIVPALSQSHRSEALILQKSVDHIHKLVAAKNDLKERVRELQTVLGEMPPDDDSSEDEINYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKY9</accession>
    <name>A0A8H7PKY9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_001292</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKY9"/>
    <dbReference type="OrthoDB" id="306304at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SB" evidence="6">
        <location>
            <begin position="98"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2175645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="174" mass="20023" checksum="801155F55AB5F637" modified="2022-01-19" version="1">MQSNPTDLTPLQQQAYRKLVDRMKDFELSISVDMDRLLEANRQLNDGEQQIGYEQRLLTDAKQRLQNNIELVQQKNQEIDKTLEQVNNLPDVVVDESLCGTTVVYNQLFDLVAEDNAIVDTIYYLSRALNTEVIDLATFMKASYQMSDLTRTLSKEQFMKRALVQKIRESAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLC6</accession>
    <name>A0A8H7PLC6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC3/GANP/THP3 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLC6"/>
    <dbReference type="OrthoDB" id="264795at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="2">
        <location>
            <begin position="160"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="2">
        <location>
            <begin position="239"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2175579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1244" mass="142453" checksum="BF426496848E400F" modified="2022-01-19" version="1" fragment="single">MNTSLSRGRAASVSANRGSGRGRPKAGSSSPFTPHTIGQAGKNDNAWPNYKGGQQSKRGNGRKQPHHRNNALNHSLDDILPGSDDEIVSQPRGKGQTLDERAARFSAHANAKKVHYEEIQLKKQRAHEREIAIEKGLIDDPDKPRKLQDAIKFAGTCQDMCPQFERLERELQHGLDSLEKDEQGNADPAKCVKTYRRSAAGNEQELPSDVRPSPVLEVNFYLTRFEYSYEKSSKTCVPQRTLDYLFNSVLGSNPIERCHVFVRDRTRAVRKDFGVQNIKDMNAVLAHERIARFHILSLHEMCELDEEKFSEQQETEQLRKVLVSLAQFYDDLNKVGIRSENEPEFRAYQILSYIRDQDTVRWAQTLPLPIFKHPLVQRALDFHALAQRNNEIMGTSARRNKPTNCEAAQNFFTRFFKLVADRETTFLMACMLESHFPDIRKGAMKAMNKSYHARYSGLSAETVRQMLGYDTVEDCIKEAELYGIPVDYSKPVPTLQFSTVTLTGTRKQLFIEPLSNPKTKKSHLLVEPKKAGMSYSQIISSGLGGAVRIRTNNAVPIIKAPIIQSQNAQTTPYFSQFTSSTRRETAPSIPNKSIVPAVKAAPTFPAQLKAGFFARANVEAMEQKYKPSASQQNQQSDAEKLQAQKEASEKAERQLAEAKRQLEMAEKAKAEENKRKQEAEKRRLQAETEAARAAEAERLRQLEEVKRRAEEEELAKKKADEEAQLKFLAQTRKMAIVSQLQRKLCNELIEEVLQQQVRQIAFARYFDLTRMKRVVNVWRARTQKKVSERKAEAKRLEKIRQTLSRMHVANPIVLARLNIQEDINMNSTPPKIQHNPNGTEYEDIEMYTEQLIRDVEQESKWRDQLWQKVDFAKYLYPDLLPASSTNSMTSKPQQWQLLICMESWTSQPAQWLLHKFDIDAVSGMKRVQHPQLDFVFNATTSDSTVDDKSLSNTGAIIFQLSDQRQQQYGDIEDSEYWTREKTRFHAFLQQLHQTMPQFRAPVLILYWPFQQNLDEDLSKLIPQLINVYNSSVVSDYRVVIMTPQNACEELPSSIEWLGKTGRKPAPLFKTPKVEVTMQKLWEIMNWSMAYIYQQMSQAPNTVENTVQGLNHLVSIHNTAMKHLNSIINNGVFYDTYMLPNMKTRPFSGRTITSADLYLLHTEWISQIQFNLPKLTVPSTAQVTGTAFHEIQDQLLECKATAANDTQVRGEIELFQQQAIDILQKSVKSVKKRKYPMDGLTLSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLF6</accession>
    <name>A0A8H7PLF6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Exostosin GT47 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_005396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLF6"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062">
        <property type="entry name" value="EXOSTOSIN HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062:SF281">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exostosin GT47" evidence="2">
        <location>
            <begin position="34"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2176163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="398" mass="46682" checksum="687E8B80D6DE6D4E" modified="2022-01-19" version="1">MSPSNIKKPRPAPLPLVNTKDYWPPRVEDALCRPKIYVYDIPASIQVSKTARETTCYRSNYKSELMLHDALTDPSSIFNKLYVTKNPEEAELFYIPFFGSCWLFSQCWSQKNWNFEERCGVDDAYVNPVMDYIIKSNPYWNRTGGLDHFMVHPMDHTYNYYQSNERFQPAMFLTTIGDKREAAMVKLRFGRDIVIPSATELLHMAKLDPMSYLTSTGSPQYSVERTRKRNILALFRGLGEDNKPEDIYSHGVRSLLFSYFRHLPNWDIADRASTEEYALLLARSKYGLAPEGWTLDTTRVWEYIAFGVVPVIIADGIVEPFENDIDWDSFSVRVRRSEVHRLDEILLSISDEEYERKRINVWEHGRRIGLEKEAWHFIVRDLCRIRHIHRPENLHLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLK0</accession>
    <name>A0A8H7PLK0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SCAI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLK0"/>
    <dbReference type="OrthoDB" id="525027at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022709">
        <property type="entry name" value="SCAI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21243">
        <property type="entry name" value="PROTEIN SCAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12070">
        <property type="entry name" value="SCAI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="700" mass="78466" checksum="CF753E79D65E38FD" modified="2022-01-19" version="1">METRTAAKSIQPASSKEEPRQFQGGSVPAEGSMDRDDNSPVVSAPIATSAVVTESDETAMKNQKLVEEFQYLLEKSQSLFAGLRDLPPTGSNRQWKPYFEKTFEVYTKVNLTEIVQLIAEHFPLFSGLKGVCIWCRAILEDKNYYGLKRWEIGEIASKIGQLYYHYYLRTSETNYLNEASVFYQAIHDRQYFKDILDVKNPALMIKKMRYYARFIVVCLLLNNNDDIRYLVSELEGFVDEYVKTFKPGDANEWHMVIEEITTFMDAEKKLIPINADKKPVNVVHRLPAYSIPLKDKDTAPKLRLQEAILVGNYQKQIKFSELTLDMYRMLQSLEKEPTTTRPNSTVAAANNEGMDGDKKEGPPSSKIQKLDDQATVKSAPNAAQTSNISATSTVTGANGPTEKMAKRVNPHKYLLHRPALSQLMVYISTAFKDISDTSAMLLYLSADGLSKQENTATDGDKIVKTLGYSAGVTTSQRKLNEKGSETSSPLGLASGLYPGDLVPFTRKPMFLIVDSNNSWAFKDMANVFDQPYMAILSPMEYPSSVQDKSEIGSLFTLFLHAPLLGFCAVSDIGNLEQTIWNQCVSKVIELELKISDLLLSHPETDSSVMRFMQDDFLRSFIVRTVLCTVILRCHLSFKEEKSYPATHPSLPQDIYSSPEVIIMLRDLTLLADVSTYFTFPASYVNPAPTTAPAAPTSNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PN89</accession>
    <name>A0A8H7PN89_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_007809</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PN89"/>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11281">
        <property type="entry name" value="ADF_drebrin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11819">
        <property type="entry name" value="SH3_Cortactin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF25">
        <property type="entry name" value="DREBRIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="ADF-H" evidence="5">
        <location>
            <begin position="6"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="389"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="475"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="175"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="453"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="211"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="316"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2177152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="535" mass="60369" checksum="16C47C43969C445B" modified="2022-01-19" version="1">MSLQVGFSTHSKDLQNAYDQVINSSSPVNWLIYTYDKGTNDLKVQATGEDGLEELSEEFIDGRIQYALARVTDPNTELPKLVFIAWCGTGVPESRKGLFNSHLNDVSKYFKSFHLQINARNEGDVDPDAIMKRVSESSGANYSFHKESRRMEPAITPVGSVYKRTEIPDIATMQRQTMKSEPAPAPVSSVHQPVRTTPGKLASKWGQDQDDQSKADQVRADRERAEKEAQERDQAMAAEREQRAREDAAKLEERQRAQQEAADNQRLRQQEQDRQRQEDESKRQQQEDLQRQQEEEALQRQQEEEALQQQQEEEAERQRLEEEESARQHQAEQDRLAGEEAEKARQQQEEEERQREEQAQLEAELAASAQHAAQTAGHAADEAVEHQQGDSVSAVVLFGYDAAEDNEMSMAEGEVIHNIEQLDEGWWSGVSEDGTRSGLFPSNYVQLLETTPEAQEPVQEEAHAEPEPEPAAAEAAGPSAVALYDYDAGEDNEISFKENEVIRDIQFVSDDWWSGLAPDGTAVGLFPANYVELQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PP01</accession>
    <name>A0A8H7PP01_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="3">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_007837</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PP01"/>
    <dbReference type="OrthoDB" id="7773036at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF2">
        <property type="entry name" value="CATABOLIC L-SERINE_THREONINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="7">
        <location>
            <begin position="19"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2177180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="434" mass="46436" checksum="27B3CD2B64165A3F" modified="2022-01-19" version="1">MLTSQDDNQVTADNEYLHVKTALLHSPSLSMKLRCNTWLKMENMQPSGSFKIRGIGNMCMKAVELRGPSIHFVTAAGVNTCLAVAYAARQLNVEATIVLPKIVDERLFDLVKLEGANLIAMGEDFEQAEVHARALLSKMRNGIYIPSSDNPCIWEGNSTIIKELKTQLRGEPPAAIICPVGGGGLLNGIITGLQQVGWKQVPVIAVETHGSNSFQAAVVAGKLVTLPKSKTIAKSLSVRTISSKSLELSLDHPVVPFAVSDAMAADAVRHFADDHKTMVEPACGAALSLCYTQVIRDILPSLSENSDIVVIATGGSDIFLDDLDAFRRKYANPPIVVKSGSEVFLKLGDSLSSIADVDTEAAAAAGVGMAVIDNIRNDRDPGALDGFTRVVNSAKYIASEQQNKAEISNLQDNEGIAHEQASLPSIKQEIIPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPC6</accession>
    <name>A0A8H7PPC6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPC6"/>
    <dbReference type="OrthoDB" id="2115692at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="474"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="641" mass="72491" checksum="9C4C7D09D4D7FE91" modified="2022-01-19" version="1">MLTSTSPEQPMLGAQSPLNKALTKPTVDISPSTPLSRNSPTLERVNRLLSRASRKVTPSTPSTPSIPITPMARLGVASTPRSSRPTPRSPRTSRSVEQLAMYRRTSITKSATTPAAATTPASGLDSPRRSQEIHSLCRRIAFKQNVFNLNSRSISNDTMRDFFLDLKERNRVERVRHYQNERKHEREKRWYRLRGTKAGPLHLLTELEPSPLGRAPLTRQPTLQDVCLSFKPGEHHERRGSWHIQAKKARKDEENYRIEKLKWYKNARIALLTDNTSEMLQPGPHAVFVTDLSSFTPLNRCNECYSDDCFHQFETMATYRGKFAILARRSANRKAQLKINTRKPSIEFTDWANRGKRWGQLRLQSVLNMGKAARGWEVLKRRRVTTTPTVEKRRSSASITSLDKQSTNSNLDPDLEIDLDQTVLAPNESTKNRAAKKNNGRISPMDDGTAGNPMDNILVVSPSDSNAVCTGAIITIQTIGQVLQNKTLKQLFFMANEAVRLATERNENSSMDVSLASSLEDYLSIDIFCDEAMNIKGVLEYIFLQRYLCINKIVIPEKYQGNGIGSVMMKRMHLLAKWRHKDLLVYAPPKTVPFYVKWGYETRKDIIADDDSVVMVKPVAAPERAESYGFSIGKCNTLLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPJ2</accession>
    <name>A0A8H7PPJ2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SWI5-dependent HO expression protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPJ2"/>
    <dbReference type="OrthoDB" id="2378230at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="66"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="34805" checksum="16FD81C27C4522F6" modified="2022-01-19" version="1">MSQSPRRLSISRIRKFEYELTAPPTPIPSPPQTLLQPPPLKASTSERSLRVKHELQAHLQQIVSKLDLYKSELSIATTQQEEHENKCIIEKKKTADLRQRVSQLSAGLESKQAQLEEIRRTTSDAEDRVRSLRERVTHLRSGQMDSDEREVYIIKETERYREMKQMTENRLVAAGSSLDRLKHRYEIEMSHLTQELNRLRALCQHKRLAAQFSMMESERLISSMLEEQEYARQGVTEAYQQLADKDHQIQNLALKDIQTLQNNIAVWDTADTQLGQQVRECLRNMQSLSNRIRIYQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPP0</accession>
    <name>A0A8H7PPP0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003392</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPP0"/>
    <dbReference type="OrthoDB" id="10265969at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="NADAR" evidence="6">
        <location>
            <begin position="95"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2178139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="432" mass="48046" checksum="6E7993EDC88FC53D" modified="2022-01-19" version="1">MSNSNDQSAESSPTNTTGQAENSSTTGSLPLEFEDSELFRNDTVFVLSSASVVKPVGTAPGEMCPVADIKSNAYYALNDNHPHWRRMLSTSYMRTMFTNSAKPSQKQTRVLRLFDLDHHGWASVEHCLQYLKLEPIDPDYASRFAMGDNKSHAFSRAEASVARRAGQKALLSDEQVRDWNERRPRCILRSQWAKFQQNEDLAQVLLATGDAKLVSITGKSKVERVERELMIVRKMLREGRDGRAILGLSADEEVTFESILHDIEDDEEDSFNVTVTIPKYSKPKTSTNGTTISPAPNTAVAAASVSNDKPATANDTTKAEESAPALKPMNVTDAMAYIQNIREHRDPTVYDNFLKIMTEFKSQRINTPQVLERVATLFKGQPTMIRQFMQFLPPGHVLQSADAEKSDAQPIYVLTPAGSRIIIDPTTGTIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQ41</accession>
    <name>A0A8H7PQ41_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_002997</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQ41"/>
    <dbReference type="OrthoDB" id="1594986at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00014">
        <property type="entry name" value="CH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13246">
        <property type="entry name" value="PH_Scd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010481">
        <property type="entry name" value="Cdc24/Scd1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033511">
        <property type="entry name" value="Cdc24/Scd1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053026">
        <property type="entry name" value="CDC42_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06395">
        <property type="entry name" value="CDC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="177"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="375"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="4">
        <location>
            <begin position="770"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="617"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="647"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2177750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="856" mass="96391" checksum="CBA36E0DDC640247" modified="2022-01-19" version="1">MAQQIDLPTPATIHSNKSVSLYHTCLTVLDKLACIPGFDYYEIQDVSTPTSLTVPSSTATVDPVSKLWNICRKGSSLCFLFNTLRPHTPVKVNEDASLTSANACKANVYHFIVGCQKELHFSDDDLFTICDLTQDDTNGFVKVVHTVSKILDMMQAEKIIKVPSLKRVSDPGAPKDIRAKIVNELVETERKFVQDMEALQDYMREIQTQKILPPDTIHYLFSNLNALVDFQRKFLIKIEEIAEQSPATQRFGQLFIQMETVSSVYDVFCANYPMALDLVIQETPKLQKLVDIANPTYELQSLLIKPVQRLCKYPLLMQKLIEETNVNWPYYEETKEGYEAISRAASRVNEVSRRIENQKCLEVLKQRVDDWRGLSVDQFGKLLLDGKFIMSSNDAEKELLVYLFDKILIICKEMKEGAKSRLPKTNSIGINKKKRRASLLLKGKIFVSFIIKVVNTSGDGVYSLKIYWQNNDVESFSLKCRNEEDLQRWESTLNNLLGETNKRQTAESEFDIKQYSTNWQQLSANGNPINTVPGSNDEDDEPGIDENDDEEDYDCDGDENTDRQYRARSGSVNNEAEHAKYYASKHRATGGLAGVPGAVPMRHYNTIPGMTLPPLPRSNYSSSSASTPTSQTDYNRYPASPPPSMPSSPTSSARASSGSNSTINVWQRRGVDIQLTDTVAKFMIGDEIPTPTDEHRSYATIPIGRTQSQTPTGVKKSSPYGSIQSIQMRSRSKSSPDVHKSRNSWGQMKDHDVYGLPFVRPLPFNGDVTSNQVKIKLNYPDGIYVIRVESQIKYTDLLNRVARKIGSHRLSTSAESLRLKYQDEEGDYITINSDEDVQMGIEGRGTGNTVNLFVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQ53</accession>
    <name>A0A8H7PQ53_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Survival Motor Neuron Gemin2-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQ53"/>
    <dbReference type="OrthoDB" id="197400at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22851">
        <property type="entry name" value="SMN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040424">
        <property type="entry name" value="Smn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049481">
        <property type="entry name" value="SMN_G2-BD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267:SF1">
        <property type="entry name" value="SURVIVAL MOTOR NEURON PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267">
        <property type="entry name" value="SURVIVAL MOTOR NEURON-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20636">
        <property type="entry name" value="SMN_G2-BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20635">
        <property type="entry name" value="SMN_YG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival Motor Neuron Gemin2-binding" evidence="2">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="209" mass="23666" checksum="776C35A92AA5C849" modified="2022-01-19" version="1">MTEPYDEDLPDAEAGDEEYDEEYEEDAEYEDFDAPQVGDSIPISTEDNDAWDDTALIEAWDEAVKEYQTYHSAPAPDDPPFSNKSSKSESTHRKRVAPPKTAKDMNGSSANKKARRVKTPATKPAPRQEDYTAPEEAQQQEEHQTDWNQNYWAYQSYQDNAGSSIPPPPPPNPPQASAAAGEDEALSNLMMAWYYSGYYTGYYQAMRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQN6</accession>
    <name>A0A8H7PQN6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQN6"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034478013" evidence="1">
        <location>
            <begin position="20"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2178135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="66" mass="7127" checksum="23FC9DDA25B73952" modified="2022-01-19" version="1">MHTKIISLAILLAAATLQAAPVLELGEVDDKMVVHALPVVPHGLKARGEPEDIQTRKTTCRNDICN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PR34</accession>
    <name>A0A8H7PR34_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldose 1-epimerase</fullName>
            <ecNumber evidence="5">5.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_003483</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="5"/>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PR34"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008277">
        <property type="entry name" value="PRK11055.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF6">
        <property type="entry name" value="1-EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034803919" description="Aldose 1-epimerase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="104"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>beta-D-galactose</name>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="202"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>beta-D-galactose</name>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>beta-D-galactose</name>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2178230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="387" mass="43210" checksum="2397C798BF946C28" modified="2022-01-19" version="1">MKFAFAGLLTLAASALAFPTRGDHGSHGGQTLPWDDKSVYEKHTIKAKGIEASFMEYGAVITNLWVNDKHGVKRDIILGWDDTTQYNVNPQHPYFGALVGRYANRIKNGTFEVDGTKYYTPINEHGVDTLHGGLTGTDRRNWTITDKGEDYVVFEMFSEAGDQGFPGNLLTKVKYSVNDNAQWTIEYDGTPDADTPILMSQHTYWRLDAFTSSDATVKDHVMQIKADKFIKCDEYEVPTGEISTVKGTPLDFTEPKAIGKDLLKAQECGTNCTGYDNAWVITDPNPKEKTLVVYSPVTGIELSINTDQVAYQFYSCVTMDGTIPIKKTQLDNGAKHKMVEQYGCFVLEAENYIDGINNPQWGEQYTGLVKAGDKYTQKTTYTFGIHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRI6</accession>
    <name>A0A8H7PRI6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial Rho GTPase</fullName>
            <ecNumber evidence="15">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_003442</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Mitochondrion outer membrane</location>
            <topology evidence="2 15">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="15"/>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRI6"/>
    <dbReference type="OrthoDB" id="10020961at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01892">
        <property type="entry name" value="Miro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000011">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000553">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021181">
        <property type="entry name" value="Miro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020860">
        <property type="entry name" value="MIRO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08355">
        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037488">
        <property type="entry name" value="Mt_Rho_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51423">
        <property type="entry name" value="MIRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 15" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Miro" evidence="17">
        <location>
            <begin position="2"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="174"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="297"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="17">
        <location>
            <begin position="406"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2178189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="633" mass="70876" checksum="92B04275ADE3F02C" modified="2022-01-19" version="1">MRRDVRILLVGDDGVGKSTLITSLIKESFIPNIQHVVPEVTIPPEVTPEKCTTHIMDSSARPENREQLETEIRKAHVICIVYAINDPNTFNRLPLFWLPYIRSLGVNVRILAPFDIGPLQIIHNNNAIFEVETCVECSAKQLLNVSEVFYFAQKAVLHPTAPLYDSREHTLKPACVDALKRIFQLCDTDKDGALNDEELNEFQRKCFNAPLQAQELEGVKDVVREHEPTGVSEAGLTELGTFGFLFLHTLFIQRGRLETTWTVLRKFGYGDDLSLRQDFLLPLFDVPVDCSVELSPDGYQFFAELLQAFDKDNDGALNDNELNSLFGTSPGNPWAQITAFPHTTITTESGAVTLQGWLAQWSMTTLLDHQTTLKYLAYLGFEGDTRRALKVTRPKKQDRKKGKVQRNVFLCYVFGAPGSGKTSLLKSFVNKPFSEKYVPTTKSFNVVNSVEMKGVEKYLVMEEVGAKNEAEFLSNKKRLDACDLLCFVYDTSDVSSFEYVAALREKYKIDHVPSVYVATKCELDLVTQRYDIQPDVYCRNLELAVPLSVSAKEQQMADLYHILTGVAMNPAIATPGSVKDAKSQNWTTRRYVTISVVAGVVVLTAVLGYRLVKQHGGVAGVFSSASTSKRDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSZ2</accession>
    <name>A0A8H7PSZ2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_001816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSZ2"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2178969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="308" mass="33847" checksum="0F83BF76AB3500CE" modified="2022-01-19" version="1">MTSWRVTFDSCENPDQLRLAFQQLFAQKPRPPQRTLVHAIEACSRLAENTNIGHQTKSPTISPSADRLDAYLLSLDQPSQQSSKGIYDRGQVIQLAQDDIIGNIPSNRMTAPVYASYLSLLANWSDLPTTLSAFNRAKKAGILPDMDMYKALITACAKTGDYDTAYKIIDEAAMAALKVMKTGYWLQIALRLAVGAEVGKYTAIGLMGLVPNIGTTIPAGAGLTIGVIVGARLAVGTALREATIFLPRRTLLQRNIAEKGATRDQQILTEQKRSRFGSLRDVIPKSDKDVRVELNSFMVNEFRKMDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PT54</accession>
    <name>A0A8H7PT54_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_003633</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PT54"/>
    <dbReference type="OrthoDB" id="274944at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037188">
        <property type="entry name" value="U6_snRNA_Lsm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="38"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2179847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="128" mass="13748" checksum="A481C0D1D14B17E1" modified="2022-01-19" version="1" fragment="single">GGRGSNRGGGDRGRGNTRGGRGGSRGGRDSDKEKPKKESILDLSKYQDKEIRVKFSGGREVVGVLKGYDPLLNLVLDNTIEYTKDVETEQVTSKTRTLGLSVLRGTAVILISPVDGSEEIENPFLAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PT81</accession>
    <name>A0A8H7PT81_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_003678</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PT81"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048938">
        <property type="entry name" value="ATPD_C_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21334">
        <property type="entry name" value="ATPD_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="14">
        <location>
            <begin position="35"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="F1F0-ATP synthase subunit delta C-terminal" evidence="15">
        <location>
            <begin position="121"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2179892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="165" mass="17454" checksum="E821351F29DB7F4E" modified="2022-01-19" version="1">MNVLARSARAAVKPMRMARFYASEAPAAAVSDKLRLNFAVPHQAIYKNTEVQQVNLAATSGDMGVLANHVPTIEQLKPGVIEVLENASTTKKYFVSGGFATVNPDSSLNINAVEAFELSQFSPEAVKAGLAEAQRTASGSGSEEEKAAARVEVEVYEALTAALAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PV53</accession>
    <name>A0A8H7PV53_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit</fullName>
            <ecNumber evidence="3">2.4.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GlcNAc-PI synthesis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_008721</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PV53"/>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03796">
        <property type="entry name" value="GT4_PIG-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000026">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039507">
        <property type="entry name" value="PIG-A/GPI3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="11">
        <location>
            <begin position="42"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="10">
        <location>
            <begin position="189"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2181139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="453" mass="51483" checksum="7796CBC22D513D90" modified="2022-01-19" version="1">MPYNICMVSDFFYPNVGGVESHLYQLSQRLSQRGHKVIIITHAYGNRTGVRYLTNGLKVYYVPTMVIYSSATFPTIYGFFPIFRNIVIRESIDIVHGHQAFSSLCHEAILHGKTMGLKACFTDHSLFGFADASSILTNKLLKFTLSDIDHVICVSHTSKENTVLRAALSPRHVSVIPNAVVASQFLPDPTAADPNYITVVVISRLVYRKGMDLLVAIIPRICAMHPKVKFIIGGDGPKRIDLEQMREKHLLHDRVELIGSVKHHDVRNVLIQGQIFLNTSLTEAFCIAIVEAACAGLLVVSTKVGGVPEVLPRHMINYAKPEEDDLVIAVSKAIHMIRYEVPKPLTFNEELKDKYSWKNVAERTEKVYDLISYSQTSPLIERLRRYYGCGFYAGKIFCMVMALDYLFWIFLEYVFPREAIEQAQPFPYKKYQSFDKSERYQTTNKVKPSLIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVG9</accession>
    <name>A0A8H7PVG9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_008917</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVG9"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF11">
        <property type="entry name" value="AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="86"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="236"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2181334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="539" mass="59785" checksum="27F61F18ACE39173" modified="2022-01-19" version="1">MTIIESTETPRYEALAQAARERREKQLPDEYRIPKDKMPDDSVKDVSNFPRESGLYTEQELEITECTVPVLLKAIEDKKWTAVDVSKAYFKRAAHAHQLTNCLSEMFFERGLEQAKELDEYYEKEGKLMGPLHGVPISMKDNQLIKGTLASIGFCYWTEEIAQEDSTLVRLLVSLGAVMYCKTSVPMAMMSADTDTRLFGTTTNPKNRTLTVGGSSGGEGALTAFGGSPVGVGSDIGGSIRIPSNYNGIYGLKGTFGRIPALGSKAGLGGQVHIKSVNGPMSRYLASVEYLAKVIFDSHPELLDYNLVPLPWREPTLPKKMVFAVMKTDNNITPTPAVTRALEKTVKALEEQGHQVVEWEPIEHGKMAKILTGFFTQDGCEFIKAALKDEPLLEYKQGNEHLLKDMPSSFVWGMQRARLDVENAVFAQWNKLGIDGLIAPVTPVPSHPHKVTISHSYTSYWNAMDYPAVAFPVLRADATIDNKPDHTPVSDDDKALWALYDAEKYDTGCVGLQILARRYQDEKVLKMASVISEALEHAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PW11</accession>
    <name>A0A8H7PW11_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit SPC19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Outer kinetochore protein SPC19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_008861</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PW11"/>
    <dbReference type="OrthoDB" id="5390at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013251">
        <property type="entry name" value="DASH_Spc19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08287">
        <property type="entry name" value="DASH_Spc19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="91"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="162"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2181278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="470" mass="54076" checksum="361E2B3E876E3797" modified="2022-01-19" version="1">MLAQSASRSQHNDSNSWAKPHSVLENLQGSVDKLSHTLNALQGSVELLQPSTKDFTRLKQVMQFQRQYDLVSEKDIKAAQSQIAQDIRPQIDKLLSDAEGAMTKLMSEERELEATVEKQEEELKVQQSKYTGSQRHGMLHDRMKQGDQDKSDPDAIESMRRIKNLKLKKDSLIRSIEDRSEEIERKEHQLRKLQGDSVRMQQIKQSTTMEGTAQESPLQQRKRQLMAELATIELKLSQKQKAIKSQRPNHSSTMVDVSKDQKPSRRRKFMEADMDGSLGNDEPHWMFYPQHLRFIQGVLERICDSSYRGDPRILKELESQGRKYLQQIQKARTTISTVSQTDRKQWKRHSVKQMKVMCKILFPDGTVGTTMGRIIEMLFCDDSTKKDGSSQKSQDDEMMIDILERGVPVKVLAREFPPAQERRHNLQKAIQILSDIGVIETLQEVDDDHDESAPGEMIIRVKGVESILQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PW45</accession>
    <name>A0A8H7PW45_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1783-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_008748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PW45"/>
    <dbReference type="OrthoDB" id="2100652at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014807">
        <property type="entry name" value="Coa1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042432">
        <property type="entry name" value="Coa1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08695">
        <property type="entry name" value="Coa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2181166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="19983" checksum="D0E4463F193CB549" modified="2022-01-19" version="1">MSGMRSTRPMLSAARAMTSTISGQTRRNMASMPRKEHRPLPTIAPRRAPMLIGAGIVGVSLWIGGLSYAMNFQRQSSSVVHGTMFTVRYHQGVRDLLGENVGYADSWAWIDGSVNHLKGQVNIKFDIKGDNGHKAKVHFASRREGANWRTIIFNVTRDDGVTLNLDQQSLTDTGAPVMALSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PX22</accession>
    <name>A0A8H7PX22_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Exocyst complex component SEC15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_008903</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PX22"/>
    <dbReference type="OrthoDB" id="10267033at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025007">
        <property type="entry name" value="Sec15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="6">
        <location>
            <begin position="87"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="5">
        <location>
            <begin position="438"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2181320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="782" mass="90340" checksum="B5D2177EEB7478E5" modified="2022-01-19" version="1" fragment="single">PSSNTLPRPLMSFMDDTAPRDPQLLQLVHAIASSSLISDNSVSLQSSIDSSSLKVTAGLDDAESIEQLGPIIKQISETNKQEAFLDQLDAFIRKKDGEIERMCNANYQEFVHSVDQLLKVRQGSLQLKRNIANLNNAVRETGTEVADKKQKLLEVRKVQYNLEKTMDSIQDSLIVLELAESVRLRIENGKYYAALKILGRLQNQHLRNVSQYSFAKYLEESIPVMQDMIKDSVNAQLKEWLYKLRSTSRKVGMLAMKYMQERQDRWRQRTAENPKLKSLQHHNVNSAIEMAVNEGNESNILDEVNIDFEPLYRCIHVHNTLGMQDEFKNSYEEDRRAQANLALTVPLNLQDGNMDNFETLLQDIVGFFIIEHVIMHSTTDFRSQAEVDALWEMVTTKVIAVISNSLRGCRDPELFLKIKYSLLIFNQTLEGFNYPVKQLHETLLALFQRYSELLINQYSEVFERIVQEDECMPMTVANQEELEEVMQFTRYQPERDIIKRNGFPFTLPFSKVFPTCCRDVSIFVHQFYQFAEGFSQTHGEMDDILKKAVDSLLISKVNAILLKKLESTNLSQIVQIIINIEYFESTCPDFEMLLMETRSFHRAGPIQLRATSTFKETRQTAEKRIFRVVNLKLDEFLELSEYDWMAQERQDQPSSYLFDLVTFLTNVINAALLNLPESIKSLIYFDALDHLSHAMMDLLLDHNEPALTDIALQNFDVDVRFLEDFVKNLGDPTIVDTFLELRQVSLLTLVQSDNAEEFLNPQLKNKKYSRVQPQHAVIVMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PY44</accession>
    <name>A0A8H7PY44_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_007433</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PY44"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="28"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2182502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="483" mass="52911" checksum="917187C13E793CDD" modified="2022-01-19" version="1">MDSDISEKFTVITAFSKSKGRRRTVYLSSILAATGGFVTGYDVGAIASILALPTFLESFPDMDVSLQSVLLMVTLAAGAIGAFSSGYFCDHLSRRYTIVTGAFVMVIGMVLQIIGLKTGLLFTGRIISSFGGGMITCTIPLYHSEIAPADIRGRLISLFSVMNSMGTLVGYFVTFGTSYLTTSWGWRAVWLIQCILCAALGLFACYLPFSPRWLIDHNRYEEALQILSSLRELPADDKQLQAEYNEIQQELELEKGFGKRTYIELFKKENFMRTYMSAGLAAGSALTGTQAVSYYAPAIFKSAGFSDVSTSLAATGGLGAASLLGTCVTVLWLDKFGRRVYLISGAFILFVAMIIIGVMFSCYADVDSDGNITMHSISARNVVIAFLFLFNFVYNATLEPISFVLPAEVYNMRCRAKGLAFATGLWWICAIFTTLIMPPLSNTYPASPYYLFAGCSFVVAIMMCTFPESKDLTLEQMEVIFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PY72</accession>
    <name>A0A8H7PY72_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_008904</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat MORG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PY72"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051980">
        <property type="entry name" value="WD_repeat_MORG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842:SF3">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="12"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="222"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="264"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2181321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="296" mass="32550" checksum="BF0EE108DB06F730" modified="2022-01-19" version="1">MAPYPTKSVRTLAEHTGAVHCVTYNSNGQYCLSGSRDRSVMLWNTATGARIKTYSGHGRDVLDVAVTRDNSRFASCGNDRAVLCWDVSAGSVIRRYAGHYESVNCVGFNDDGTVLASGSFDTTIRLWDCRSQSHSPIQILEDCKDSVMSLQIVGVELIVGSADGRLRNYDIRMGQLHEDYIGAAITSVRMSKDRNCILVSTTDNTLRLMDKANGTLLNEFKGHQHTDYKLHSAFSNDDAYVLSGSEDSKIYIWDLLEGTQVATLEAHKGSVTSIDYHPTDPSMISGSVDGSIMIWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYL8</accession>
    <name>A0A8H7PYL8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYL8"/>
    <dbReference type="OrthoDB" id="2282382at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA" evidence="1">
        <location>
            <begin position="98"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2182305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="223" mass="24697" checksum="B673BCA9B38D759B" modified="2022-01-19" version="1">MRFGTRLSAGQNFQIPLEAVQPYFSSDKLSLGYHFSTGAILQLRDNSATSNFVVLHVGSSHGLSYQQIIAARALFGSSSQSYKAADLIMFDPRSEAFSACSDYTYEEEEIMDGKVVMVGRSHCDFHEQALKAQEAGAIGIIMVNGEQNRVFNAGGIPSIKEKIYISCFMVSLEDASELLGYRMDHAFPLRIPNVKILDFPRSRLSFDTKLIIKGSTVHNIVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZ12</accession>
    <name>A0A8H7PZ12_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromatin target of PRMT1 protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_006334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZ12"/>
    <dbReference type="OrthoDB" id="5599506at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Chromatin target of PRMT1 protein C-terminal" evidence="3">
        <location>
            <begin position="73"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2183329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="178" mass="19334" checksum="9BEAD443D53CD739" modified="2022-01-19" version="1">MPTIRYCRFSQIAKGTTSVQKGKPAIANRLGPQKAGKINAANIQNRLGKPKNAGIKKSGPVRKLKGGATPMEGVQRTGKVAARNQKGLANLRQKKGGAVSAQNKLGRNKGPQRAPAANGKDKAQDNRKKQDQKPKQVSKDDLDKSLDEYMMKDPKTAQARLDDELNQYLADGDLVMDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZQ4</accession>
    <name>A0A8H7PZQ4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="2 6">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_006232</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="2 6"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZQ4"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.170:FF:000003">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000042">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="9">
        <location>
            <begin position="116"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="10">
        <location>
            <begin position="289"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2183228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="502" mass="57256" checksum="D4FD1E9E3FA08193" modified="2022-01-19" version="1">MPQKKDKGKAKADAPPKEITEKDLQKLASSIDKIAGKVQARQEKALAKGEAPKEKKVDPVKEAEMRKKVEQMLQALSTMEQTGAIKASGQKDMGSHQFWNTQPVPQYGENITEEGPIEPSVPRDQVRQEPYALPKEFEWCEVDITNEKEITELYQLLTLNYVEDDDAQFRFDYSAPFLKWALQPPGWKKSWHVGVRVSSNKKLVAFISGTPAAVRSHKTVHHLTEINYLCVHKKLRSKRLAPVLIKEVTRRSHLEGVFQAVYTAGTVLPKPVATCRYYHRSLNPKKLVECNFSRVPRGSTMAAMVKKFKVAEEFSTPGLREMKAEDAPQVKELANKYLSKFDVAPVFETDDDVCHWLLPTKDVVWSYVVEDPKTHKITDFFSFYTLPSSVIGNAKHSSLNAAYMFYYAVEVPEKEAADSYDNTRYTKQRLTELMRDALVAAKKVSEYSLTANFDVFNALSLMDNSMFIDDLKFGPGDGYLNYYLYNWRCREIKPHKVGLVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZW1</accession>
    <name>A0A8H7PZW1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_006323</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZW1"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2183318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="41881" checksum="F85828090C4F7C75" modified="2022-01-19" version="1">MMEDEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLRYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKSNREKMTQIMFETFNSPAFYVSIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYSLPHAILRLDLAGRDLTDYLMRILAERGHAFTTTAEREIVRDIKEKLCYVALDFEQEMQTAAQSSALEKSYELPDGQVITVGNERFRAPEALFQPSLLGNESPGIHETTYNSIMKCDVDIRKDLYANIVMSGGTTMYPGIADRMQKEITALAPSSMKIKIVAPPERKYSVWIGGSILASLSTFQQMWVSKQEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0F7</accession>
    <name>A0A8H7Q0F7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_007376</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0F7"/>
    <dbReference type="OrthoDB" id="2018507at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14037">
        <property type="entry name" value="STKc_NAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="68"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="353"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="458"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="710"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="458"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="599"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="629"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="728"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="759"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="782"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="826"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="847"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="873"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="906"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="930"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="962"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2182446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1027" mass="113123" checksum="5AFEA23EC14270AD" modified="2022-01-19" version="1">MSSAFNDFSSPSSATQYQQDYRQRIPQQQGVGQTLPPNPVGSIPHNTPPPPPGAMPPGTQVVVGQHKVIIQVYLAEGGFAHVYLVRMKDFSDPIVLKRIAVPDTERLKSVEKEIVFMRRLGNHKNIVRYFDSQVSPLPTGGFEALILMEYCPGGGVIDLMNRRLQQRLTEPEILKIFGDVSEALAYMHYCNPAALHRDLKVENILISASGRYKLCDFGSACLSKGQYIPKTLPEIQKLEDDIQRHTTLQYRAPEMIDIYQRRPINEKADIWALGVLLYKLCYYTTPFEEQGPLAILSAKFTFPHYPQFSDKTRNLISWLLTEDQERRPNIYQVVESVCKLRGKDCPIRNIYANNSVTSSPKSQTGEQTKSANERHGSDNIFEQRVQPKQHTPNITPMRRGRPDRKDKENHDPITKEDKVSKDKFDPFDPNISSPSQRKQPVLDFDPATVFSLNEKTAFTSKSASTDSETQNSQSRSEKLATSSAQTQPPRFTSSPVGGQSQSSSVKPNQFQHAAGSSTPDSFKSPSLNPRIQHLTGDSKFLPATPSGGQSMSPARTPSPAAYSPNANVTGERLQQAVTPSDLLKNSKLETSSAGSSPVRKFEAPKKLPDIKPDQFADLNPKITQAALPRSTSMQAGGQATTASNASRASFDKIKPSFSSSKGDSVEDFNLKFPDLSSLDQHFSGASNSSRKNDGSAAFAAIDKFDNKADEQPVIVSKSNRHSVFDRFSSLTEETKASPNRRSSMNSTDMNSKGNQIQSKVKEQLQRFEMANNERKAAEQRIQRSSTKATPSAPKSESNDVKLQESKVAQPRGTEWQITGHQRERSPSSSQASSAKEPSSELAEMKKSLQSYRQMLQSPSPSPSPKDDTATFDFVNTKTSPERFSSSAKSPTKSPVSSAATLVDASPSRSSTKSPQDIASLINRQKEDTTPSKSASPSPKSVPATQTGPYRPTPPPKPARFRMSSTMVTVLTPSSIANKSEAMSSPRNLVNNSQHASRTKLTREPSITDFESKFPSPEQLQEGLPNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0T1</accession>
    <name>A0A8H7Q0T1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_006451</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0T1"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22927">
        <property type="entry name" value="HFD_SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037782">
        <property type="entry name" value="Spt7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="8">
        <location>
            <begin position="308"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="132"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="395"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="745"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1030"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="745"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="768"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1074"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1130"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2183445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1158" mass="130555" checksum="16A6227F1E78388E" modified="2022-01-19" version="1">MEGKKGQQLPALTKVSFIIARHLDSENLYSQYLTPSESQIFKDAVANFDKWSSFIKVANKIGTTEVDQNDEQKSVSNQMSDDQVAAFRVRAMIFDQLVPQLYQCSKPCCKMSNGIDDILKDLSNNKYDELIEQSSSLPEEPSRTVLSTQQSDAEKTPNNHVGEASESNDDPDAQQVDGEATGDALISPLELAHIPLTNVYHTFETDLVAMIEQRKLEEYEAQEEMNDKENQSEKTISILNANSNFSLKYLLEAIEQNRAVTKLGDRELRNLLTDVRPHRSKWIKANEEKLGQEELYESCEKVLMDLKNYTEHSTPFLNKVNKREAPDYYDVIKKPMDLGLVTKKLKACQYKSKKEFADDLYLIYENCLVYNTNPQASEYRKHAIAMRKKTDKLLQQVPDVSIRDRSEYDAEEEAEESDDHEEDDHKASRKAPGASKHLANKTVQAKNANDAVVSTPSDATREPSLAPSNDDSQADHDIDGNGNGNGTGQLGMKGLSGQSNSDNAIDREQEERNINAEIEANMGMIQDEIWRELTKKTRAKVSSDADKQSKIPFGERPVITRSAVDMKRFSMIEQAHNHPETVRKIITASNEGIVRWIEQGNTGLYDDCDSDDDDSFDDGFLSRRMAKSNTAQVDASSRADLYLPEYAITSGIPEIIAIPEEITDKTRRGSIDGLENELEYGLSDVSLDRYPTVAIPNHGTSEMIDQNLHTLREIRRVYAKCVAVRNDVPVSIAALNTSQAYQDDSQIGENDIASPSTTEPTMNGTVSESKEAIHDAEDKEPAQHQHQLPEEEQELVPLILNQESGQALMQRTVVKLIEHAGFEGSQTSALAVLSDVATNYFTSLGKTLRVYWDGYCNNMTDEEILTHTLYDNGIEAIQELEEYISDDIEKYGHRLNDIHRKLTSSYNELVNGSTDVQLPDDSFFQSEDAFINGALGDDIGEDFFGFKDLGLDKELNLDRINIPSRLWYGKDKAKDHVIGPKSNEPVLEFLPPPAFLRVRNTDGIIKLLQPYFQEKLEKTEGNLVEDEYQTTRRSKPRYPPILSKAGGLNRKRPLKDANGELKKAKKKKPMEMIQAERAEKRKLKQEARAQKVAEREQKKKMREELKERDRLAKLEAKREKKAMAKKGGSIANSHDTPSVTGADETSPLPLDSEEQDWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q102</accession>
    <name>A0A8H7Q102_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q102"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="66"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="323" mass="36628" checksum="E646D30E2FFB8403" modified="2022-01-19" version="1">MATDTAFEELTGDPHNVPRKMPELNWSYPCKQGFAPVAQDRSSVPVNIYYELHGDGPRRILLIMGLNTTCQAWDYQTGEFARSGDNTVLTFDARGVGWTDGSWDWYNTTEWAKDALELLDYVGWTSDIHAVGYSAGGQVLQKMMLMSLERFKSAALVCTTAGGSRPFTGAYTLIRNLFEKDPNEQLRNLIRINYTKTWLNQRPDDDSSVDTNFEKVFNLQLTRSKRNRPQQVGAIASQAVASMRHWVTAADLEKIRSSGTTFLVATNTWDNFVHTSDSFYLRDHLKPYKFMVFEDSGHVVPTAKYTEFNAALVDLWTKAELES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1N4</accession>
    <name>A0A8H7Q1N4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_006729</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1N4"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="166"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2183718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="455" mass="51509" checksum="53D518FF57EF8684" modified="2022-01-19" version="1">MAKDHSGQVSMLTKALVFSKYILTSMLPRVLSVLSRWLKLQYEDFHYDDILLQRLEAFLSGDIQRAGFTAEAKLLKESIKMQSVRHARPGHTLITLSADPLLCSEYHQGSYSSPSTPIPKSPTRSAFSSRRPSGASSIFSFVTSITTPPESPTLPNVSSSSLISFESKELAQYLTLADFYYFKCISSFEYLNGSWRTGAQMNSSECTSYPAHSYVHKMTKRANMASILSRWVAHETVSAKNLKHRRAMIRKFIEIAKLCLDWNNYHTSMVIVMGLKSNSIQKLVETWQSVPTRELSTLQSLEKLLDVSGNMRTYRTSFAAAKAPAIPFFPIVLKDLTFFIEGNKTYLEDLQPEPNFNSLSSFKQFREPPQNNEHTLINFAKFRTLTRFVMDMLALTSENYPFSGQLETTPFFNITAGFEVEYSAMSTSRFVAPLDSLAYTIERRIQIVPTSNSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1S0</accession>
    <name>A0A8H7Q1S0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_006731</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1S0"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00179">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000008">
        <property type="entry name" value="Syntaxin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="269"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2183720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="379" mass="43631" checksum="3052C713366F7E95" modified="2022-01-19" version="1">MSRDRLAELRGNSRENERGYGRLSDEYDEQPPPMPAAQYQRSPTPNSYHSHHSQDDYGYRQPASPSPAYQKSSRGDRYAEETKYADQYEMTPPPARKGGDSLASTEDFFNEVEGIKDLVRKINDQIGKIEELHSLSLVNINESQAEENSHQLDRMIQRTMKMNNQAKDRIKAIELSNASMSPTSGELPMRKTQHAALKKRFLETIQRYQDIERTFEKKYRQRVERQIRIVKPDASPEEIDDVLDSDEPPQIFAQSLMQQQRSGQARAVLSEVQNRHMDIKKIEKTILELHELFIQMNMLVEQQGEVLKEIDMHAQDTVIQLDEGNKQVDRAIVSARATRTKKWCCVILVIVLILVAAFCIWWFAFGHKGITLPSQKASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3R6</accession>
    <name>A0A8H7Q3R6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_000413</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3R6"/>
    <dbReference type="OrthoDB" id="346839at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12418">
        <property type="entry name" value="RRM_Aly_REF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF35">
        <property type="entry name" value="RNA ANNEALING PROTEIN YRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="99"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="173"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2184504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="243" mass="25969" checksum="6E35CE71BB1204A5" modified="2022-01-19" version="1" fragment="single">MDAINNSLDDVIKQGRQDKKQKSQNTKRSQGINKRPGPIRSSSSGRGSFRKSPIQGRRDTASPWKHDLYEDANGGRGSRSIVGAASSIASRLGGGAGSNSIKVENLHYEVTEADVNELFQMVGPCKARIQFDRSGRSSGAATVKFDKPADAQTAVKKYDNVELDGRPMKITIETKSEGILGRIGKPSNSNTNSRGASSNSRGASSNPRGARKPARGGRGGGGQGRRNRSENDLDKEMSDYMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4B2</accession>
    <name>A0A8H7Q4B2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="8">ATase</shortName>
            <ecNumber evidence="3 8">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_000966</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3 8"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4B2"/>
    <dbReference type="OrthoDB" id="191723at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="2"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2185053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="518" mass="57418" checksum="DF3EA455A02C1805" modified="2022-01-19" version="1">MCGITALLMADPSAMTSPDLFEALGILQHRGQDAAGIVTCGQRGRLYQCKGNGMVRDVFDSKQLANLVGSLGVGHVFQSVRYPTAGSSSTSEAQPFYVNSPYGLVFAHNGNLINAPELRQDLDARAHRHINTDSDSELLLNVFADNLQQTGKFRINEEDIFKAIKDLYVKCKGGYACVAMIAGFGIIGFRDPNGIRPVIYGRRKSDTVDGFDYMLASESVVLDALGFTDQVDVGPGEAVIITRDTLTKRTLIDDVVFSPCLFEYVYFARQDSIIDGISVYKSRLAMGEAIAEQVKIYFGDKLDIDVIIPVPDTARAAAIQTSQALDIPYREGFNKNRYVGRTFIMPGQQTRRKNVRRKLNAMSLEFHDKNVLLVDDSVVRGTTSKEIIQMAREAGAKKVYFASCAPPIRYPNVYGIDMPSRQELVAYGRTNEQIAEEIGADGVIYLELEKLIHSVQKFQPSITMFDTSVFDGNYVTGGVDEAYMKHLEDARSDSVKSRNDVDSSETLGLHNHYYDFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4C0</accession>
    <name>A0A8H7Q4C0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_002707</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4C0"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF20">
        <property type="entry name" value="AAT FAMILY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="49"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2186269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="548" mass="59512" checksum="81956805FD0C7EB9" modified="2022-01-19" version="1">MENEYEKDHQHVEEPYINGSKEANNYTDDMEGGLEMPERTLQRQLKNRHIAMISIGGVIGTGLFLGTANSLKNGGPLGLLLGYAIMGSIVFAVMNCLGEMISFLPVPGGHIKLAERLVDPALGFAMGWNYWYNWVIVLPAELSAAAVLIGYWTNGSINNAVWITLCLIVVVTINMFGARAYGEAEFWFASIKILTIVGLIILGIIIAAGGGPSHVATGVQYWKNPGPFVQYEGIPGALGQFLGFFSVLINAAFSYIGTEIVAIAAGEAANPRKNIPKAIKKVYIRICLFYILGTFIIGLLVSSADPRLGSSAGAGTAASSPFVIAIEDAGIPVLPSIINACLLTSAWSAASSDLYTSSRALFGLSVSGSAPKIFRKVNRFGLPYLALALSVAFSLLAYMAVSKNAWVVFNYFGNMTSICGLITWCGIAITYLRFHSGMTKQNIDRTTLPYRSPLGAFGGWYVLVSLCIILFFSGWEVFLAGHWDTSTFITTYLPIPFAFILYFGYKLVKRTKIIPVQDIDFVTGVREFDDEVDEEPPTTVLGKFFNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4D2</accession>
    <name>A0A8H7Q4D2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gonadal family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4D2"/>
    <dbReference type="OrthoDB" id="21617at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018858">
        <property type="entry name" value="DUF2458"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010849">
        <property type="entry name" value="Gonadal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13054">
        <property type="entry name" value="DIGEORGE SYNDROME CRITICAL REGION 6 DGCR6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13054:SF2">
        <property type="entry name" value="PROTEIN DGCR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10454">
        <property type="entry name" value="DUF2458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2185083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="260" mass="29293" checksum="C991199FFB9B2EC1" modified="2022-01-19" version="1">MSLSADELLTLIQAAQSNSQNVEGAGRGAAQVSCVALLQLQAQDLTIAHNSLNQTFASATSQAPNLQPSYNIDFSLLDPALVSQVRSEYLAQKSSNNAPPAPKAMESSTSANDNLEAAKSITPEVLVRLSQLAKDTDLLTVLHDMQEEQHNREKEMWSRREKLKGTLDKEREHLLASHQFCLRDMIGIDVTKELEELDTKIANEMKRFDHSIIRDMDRQKKRQEEELIKLQVPFFHKTQDPVLIKLQAKVFKILLDMMDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q531</accession>
    <name>A0A8H7Q531_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_002545</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q531"/>
    <dbReference type="OrthoDB" id="2403262at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090149">
        <property type="term" value="P:mitochondrial membrane fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039158">
        <property type="entry name" value="SLC25A46"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21252:SF2">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN SLC25A46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21252">
        <property type="entry name" value="TB1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="334"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="278"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2186107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="453" mass="51695" checksum="92BBBA66A3A90DBC" modified="2022-01-19" version="1">MSPPQLEAYLCRLTLGRNALADQQERNSSETAEENRHALELRSEVERSEAEVLATVGFYNAPDIQQEASENFAGFSLAVGAMVSNYVLCFPFVVARHRRQTIPSMFYKRKDSPIDTMDYLVRLQNREGWKALYPGFGLGLLAQGFAVTYESALNMILSRTINKTSPGGSLVTQVTQLTAAKVLELAVYIPLHPIYRSALIMRTQTQSPTSRRVITSYRGFWRSCKTELYRFLNYRTVTKPNQLPLVSVFVPSCLLSIISEKLLTIIYKYLNRLITKPKSTEKRSNRRNQRRQRPTTLRHSLSRDLLETPTSSPAEDTALRDTKSKRLADETTLYSFYPEIVCGIASSILTRAIVYPAETIVFRLMLQGSGVLIQDTTYTGFWDCLITIVKEEGCWNGLYAGVGSWLAEVALGYVILESSWIALKLTKWRLQRKHDREVEMEWRNRKATIRNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5M3</accession>
    <name>A0A8H7Q5M3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ras GEF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_002433</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056685">
        <property type="entry name" value="DUF7783"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25006">
        <property type="entry name" value="DUF7783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="5"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="8">
        <location>
            <begin position="154"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="8">
        <location>
            <begin position="299"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="9">
        <location>
            <begin position="881"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="7">
        <location>
            <begin position="1048"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="231"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="708"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="756"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="722"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="758"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="786"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="801"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2185995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1300" mass="146857" checksum="83CE0E51E50A7D67" modified="2022-01-19" version="1">MSGPRVICRVQAMYPYQSGDSSALSFGKGDIIEVLTQLESGWWDGWCNGLRGWFPSNYVVIIEDEPEMIAGDFGSQQSNKMYDDHENQWFDESGFQQYSESVQQQPQFREISARSKEQLRLSLASSDRSYTATPTKSRSRTNTTERYESPSIRNGLPPNWIKQTTEDGTSFYYYNVVTHKMRYTHPDEGEEDEESMGDLSDDNEPNFQVYDHQQQPDNSALHQHAIEAHGHESDISQDEDLSDRELEPRIPPRSANRIKMTEKFVDDRSMASSGNRSRLSSVSSQGTQNKYLRGMEDQEQYPPNWTKKLTPQGRPYYCNMLTNETTWNIEDVDPSTGELLIQPGTPTQATIASATEMATANVSNDHESKRSSEHSHISHRKAMDQQAGEPLNWGKLSSLIAHAIHDLNSAARNGSRHLYKDLTTAVVESIRLMLYASNSIDKENSPHLKNDKTLRAQYRAIMAALSKLVLSAKLASTMWSPPDAVVKMETDANDVLVAVRNYLGSAQEAGIEVQDNDPRLVENGATSISSLQWRRKRSNSQNTSRGLDLLEEAQPRFVLHPDQVSILQNSATGMHSAIISFIDNVRKISEKPSNSKDMSTNTSIQSATPLIIAQFRNLGNIISQFLNHVEDIAVDSSLAHAGDLKYAKQCLYNSMGALFVATQFVTNDSPSPDELDANVAQVEQCATTVEESVWDICRAMSKLTAEKMSKAPADIQPPAPSPAAQRASQRSPTNGHQIRDANDLLAWKIPETSLTIDTGRDTSQDFFSHDDDGRISPDTDVSGRDELDDILASPEDDLAQPLSQRSMSESNLNRRPDDKLKKFFGEDAAAAAKRRETTIGPPSNMSAMPSTIGAPSTLGANGDVPWYLGYDYTTNDIVFNMEGQVKGGTLTALVERLTLHDFLDSKFINTFLLTYRSFCTTDEWFDLLVQRYNLLPPQGLSSEEIEIWNDKKQKLVRLRVFNVIKTWLENFYNEEEDQHIISRIMEFAEVTIRESMQFAAEQLIKLVKKRMDTDDNSQFRKMILTLGSTAPPPILPKNMKRIRLLDVDPLEIARQLTVMDSRLYIKIKPVECLDKNWGKEDSENMAANVKASIEYSNQITAWVTDSILSQTEIKKRCAIIKHWVQVAEKCRILNNFNTCMAILSAFDNSAIGRLKRTWDSVSARTMQTLAYIRKLMGANKNFTEYREIIHSVNPPCIPFLGIYLQDLTFIEDGNTNFLRKSNQLINFAKRMKTAEVIREIQQYQSSPYVLNAVPELQLFITTHLQSSRDEETCYNLSLALEPREREDEKIARLLKESGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5Q3</accession>
    <name>A0A8H7Q5Q3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Adenylosuccinate lyase</fullName>
            <shortName evidence="12">ASL</shortName>
            <ecNumber evidence="6 12">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_002478</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="6 12"/>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5Q3"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03302">
        <property type="entry name" value="Adenylsuccinate_lyase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.60:FF:000001">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000005">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="13">
        <location>
            <begin position="371"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2186040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="480" mass="54323" checksum="FD8E21D75D88BCC4" modified="2022-01-19" version="1">MSHSKYQSPLTSRYASEEMAHNFSEDKRYTTWRSLWLNLAIAEKELGLTDITESAIEEMKANLDNIDYGVAAAEEKKRRHDVMAHVHTFGLVAPSAAGIIHLGATSCYVTDNGDLIIIRDGYDILLNKLARVIDILSKFAAEYRDMPTLGFTHFQPAQLVTVGKRATLWIQELLWDLRNFERARNDLKFRGVKGTTGTQASFMALFNGDHDKIEQLDQRVTELSGFTDPYPVCGQTYSRKIDIDVLQPLSGFGATVHKIATDIRLLANLKEIEEPFEKDQIGSSAMAYKRNPMRCERACSLARHLMTLANNALQTSAVQWFERTLDDSANRRISIPEAFLCTDILLTLLQNIFEGMVVYPKVIESRINQELPFMATENIIMAMVKKGGDRQVCHEEIRVLSHQAARVVKQEGGQNDLIERVRNTEYFKPIWDELDSLLDPSTFIGRAPQQVDSFLEKHVKPALSPYSDSLKTYAKAELSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5S3</accession>
    <name>A0A8H7Q5S3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5S3"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="557"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2186070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="629" mass="70468" checksum="D5969BAF25722C9A" modified="2022-01-19" version="1">MVVKPVRIFSLELPLVPLPLNSMTDQPTYKYGHLATAEKDTQMSDEKFNKEDLAFTEENISIPEDAHEFDGLRRVAENIPVGAWFIVLTEFCERFAYYGGSAPFQNYVQFPAGDNGIDVRGALGKGQSTATALSNFFTFFCYVTPLFGAFVADSYLGRYRTILLFGTIYFSGWLILTCTASPASLAAGAGFPGYVVSLIIIGVGTGGIKSIVAPLCADQFKNTAPVVRTEKTGEKVLVDYDLSIQHLYQWFYWAINAGALIGGIACPLIELNYSYWAAYLLPTCMFAFAMFIFVAGNKFYVKPQPTQSILVKAVKVFRFARKVANRPENKEAKKSNKYRLDFAKMENEMPNSAPLTSDDLSYMFWDDIFVEELKTTIMACKIFIPLSLYWVCYSQLSNNLLSQAAQLNRPAGLPNNIMNNFNPISLIIFIPIFDRLIFPALRKFKINLFSQQRITIGFFLGACAMIYASVLQSFIYKDPVWVETEVSSISVFVQIPAYVLIAISEIFASITSMEFAYTHAPQSMKSMVSALQLLPNCFAALIGLAISPAAVDPNLTYVYASVAVAAAIAGVLYYITFRHYDQMDEENRIKRMEAHRRNNSAPYVQYVEGKGTENEKTAHYEAEINFDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q653</accession>
    <name>A0A8H7Q653_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SURF4-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_002468</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q653"/>
    <dbReference type="OrthoDB" id="7859621at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002995">
        <property type="entry name" value="Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF1">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02077">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2186030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="31164" checksum="E69B052668920370" modified="2022-01-19" version="1">MSEVKEQIQQFSSKAEDLLDTIGQPLKPYIPAISRFLIVATFLEDSLRIITQWGDQVFYMQNHRSFFWGLSHLFLAINVVLMIGGSTLVIIKKHQDLAAYALFAVVVLQAFGYGLVFNMSFFLRNLSVVGGLLMVLSDSYTKRKQMFAALPQMSETDRREYFQLAGRILLIFLFIGSAFHGDWTFGRVLVSLIGLAAAVMVIVGFKAKWSAIFLILFLSIFNVLINNFWATQHNHFQRDFLKYDFFQTLSTVGGFLLLVNIGPGGLSLDEKKKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6R4</accession>
    <name>A0A8H7Q6R4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin-related protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6R4"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10210">
        <property type="entry name" value="ASKHA_NBD_Arp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2186345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="45485" checksum="BC259694788B5244" modified="2022-01-19" version="1">MLETLILDNGAYTIKAGVASNPNSLRYIPNSIVRGKHDRRNFVGDELYSCQNYSSLYYRLPFEKGMLINWGVEKNVWDRIFSNNVLKIDATQHNLILSEPCFNLPNLQETYDQIVFEEYDFAACYRTIGNFRKAIISVNMLSVWEADILSKLFTAPRLCLYNDIPSLYGQKQSLAPDCVVIVDVGYSFTHIVPFIDGVPVTSAIRRINIGGKLLTNQLKELVSFRTYGSKNSIIQEYVLPDFTKRNKGYILPRDEDGNLTSRKADGTDQILTMNNERFMIPEILFNPSDIGMNQAGIPEAIFQSVEACDSDAQGLLYANVVIVGGNANLPGFKQRVQSELRHLVPAEYDVRVAIPPNPIDFAWTGAQYLAAADNGARLEQKLVTRKEYLENGSEVCRIKFKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6Z9</accession>
    <name>A0A8H7Q6Z9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_002841</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6Z9"/>
    <dbReference type="OrthoDB" id="660550at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034203850" description="Peptidase A1 domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="8">
        <location>
            <begin position="77"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="9">
        <location>
            <begin position="634"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="108"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="330"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2186403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="689" mass="71956" checksum="02B25DC8A9175A39" modified="2022-01-19" version="1">MVNLLSGAIALIAAATLVLAKSASIEITRKHSPTAEQALSASQSRAKHLSTQISASKSNGDDATVAAFSLENAQYSYYMNITLGTPPQSFSVIVDSGSWVLWVPDHTCSPSSCQNAQHYFDSSASSTYSPVAGISLDAYYGKGSAFGILGTDTLSLGNGAISINHQEFGQAQSQTYITDNGNDGIFGFAPYLGSIFTNSAHDLIQNPLGNFVSQNPGYSNIIGVKFEPVPDGQVFAQNGLLSFGGLPDSSWYSGSLAWIPTVQDESLSLWWTIQVESVFLGDTGAGSIPNAVALVDTGTTLIFLDNSTFPTLYDSIDGSSMEYGYWSIPCASVKYLPDLTFNINGNSFTLTPSEYMLSQSQASTANTWGFPSGTCVSYVAQGDFSSTDYQMVLGQKFLENFVSVYDVDNKRLGLAPNAVSSAMTTSTTMSTTSTTASTTASTTTSTTTSTTTAKATTTGTANSCACNSGYSGLKKGNGPTGACCTSSDDCKDTCNKDGRCGISGVLATCTAKTTTVKSTTTAVATTSKTTTTQAPTTKASTTKAITTKVMTTTKAASTTSSNTCACTSGYSGRRNGSGPTGACCTSSDDCQDTCNKDGRCGASGVLATCKTVASTKTATTAATVTSGPVALTCQTYQVQKGDKCYLIMHRFNITSKEFYAWNNEIKTDCSNIDEFIGETVCVSVPTATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q7K3</accession>
    <name>A0A8H7Q7K3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_002649</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q7K3"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="309"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="372"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="412"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="210"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2186211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="813" mass="89297" checksum="286A54C83E7FD626" modified="2022-01-19" version="1">MNILSNLVPKFGLANSKTNETNVDSDLHEAPQDLSIVEAQHHGQSVGEGDTDTAPGHINIPPNDFSDTTSSGTPYSAYQTPSAAMGLDSVSKSLEHADSHNAGKRDRPESQPSIDPLSAHIIRRVSYRVKPEDDVKPLASDMKPIPDSDNTEQDTPNETSDSTPPQTQTSDAQIKAGKSSLFSRIGRKKPEHKTIPEHKAEEAVAENDDVSSLSSTDGRNSIDSQRSAARSNITSNNRAMSAAPHGLPVVKTRSKIKANRAFARMVFAQTLTAPRLDTNATPTDTNDSKPVPGINEDDYFSGEELVGAVWVLKFSKDGKFLAQGGQDCVLRVWQVLGQQANSTLAVPGEHNRNSEATNETIKVFEDKPLHEYEGHMADILDVSWSKNNFLLSSSMDKTVRLWHVTRKECLCVFQHLDVVTSITFHPRDDRFFLSGSLDCKLRLWNIPDKKVAYWNEVPDSNMVTAVGFTQDGKIAVAGSYVGSCFFYETEGLRYNTQINLTPSKGRNSKKARKITGIESMPGMPPGEEKLLITSNDSRIRLINLKDKGLVAKYKGLDNPSMQIRATFSDDGRQIICGSEDRNIFIWETEQAGFSPFHYLQDSRYKTAATLGHFGEQLVQTAVNSTHHNGQPTRVSGWLKRGGEKVKEKLKGGYEYFEGHSQVVTTAIFAPTRTRQILARSGSDTIYNNTIIPDEPKKSIGNRLVRSGSTASRVSTSQAELEAEQSEQARQQALNYTYPDGHIIVSADNVGVIKVWRVDCGNYGAGSNLLSPTTSRQEPVVGNSVHLHSVPSNDSTIKPAKAKRNIASMFGKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U6R5</accession>
    <name>A0A8H7U6R5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ornithine carbamoyltransferase</fullName>
            <ecNumber evidence="3">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_008061</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U6R5"/>
    <dbReference type="OrthoDB" id="10252326at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019240">
        <property type="term" value="P:citrulline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000009">
        <property type="entry name" value="Ornithine carbamoyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001986">
        <property type="entry name" value="PRK00779.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753">
        <property type="entry name" value="ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753:SF3">
        <property type="entry name" value="ORNITHINE TRANSCARBAMYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase carbamoyl-P binding" evidence="9">
        <location>
            <begin position="15"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase Asp/Orn-binding" evidence="8">
        <location>
            <begin position="182"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2171681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="343" mass="38125" checksum="274FEB689AFD9A53" modified="2022-01-19" version="1">MPSSKSFSTKTEKPQHFISTADLTKEQLYNLLTRSIELKVEAKYNVSTPVRPLTGKTLAVMFSKRSTRTRVATESAMAYLGGHSMFLGSQDIQLGVNESLLDTSRVVSSMVDGIMARVNGHDEIETLAKESSVPIINALSDKYHPTQILADLVALHEYRHHGSINPAEYTAHQQHPSETLPGLKVAWVGDANNILQELMVALPKVGIHLTAACPEGYTCQQDVLEIAQAEAKREGTTLAFTHDPEEAVKDADVIVTDTWVSMGQEEEKAKRLAEFKGYQVTMDLAKRGGAKPDWVFMHCLPRKPEEVDDEVFYSDRSLVFPEAENRKWTIMAVLDSLLVKKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7C6</accession>
    <name>A0A8H7U7C6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_005231</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7C6"/>
    <dbReference type="OrthoDB" id="88at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="7">
        <location>
            <begin position="30"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2173811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="136" mass="15526" checksum="43B2226C044BDA3C" modified="2022-01-19" version="1">MSAQRLASVTKNGVGTYILQCRKMVFNYCENWGSNKGMIQYLKKDLVEFAKANPQIEIVVEPRPAHHPIIRGEYLNGRDKVICVRNMENSEIKRKVQLLRDSSGSKLKNLTKKSVISTSESVRGIWSPFHTNPHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7S5</accession>
    <name>A0A8H7U7S5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_001532</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRP40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7S5"/>
    <dbReference type="OrthoDB" id="340500at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22526">
        <property type="entry name" value="KH-I_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05790">
        <property type="entry name" value="S1_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000112">
        <property type="entry name" value="Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000038">
        <property type="entry name" value="exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049469">
        <property type="entry name" value="RRP40_KH-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041054">
        <property type="entry name" value="Rrp40_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037319">
        <property type="entry name" value="Rrp40_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18311">
        <property type="entry name" value="Rrp40_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exosome complex exonuclease Rrp40 N-terminal" evidence="11">
        <location>
            <begin position="34"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="161"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2172055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="240" mass="26252" checksum="1FDC2741E9A07B66" modified="2022-01-19" version="1">MTSDLKVVLPGDLISVNNESDESSMNVDDDVPLVRLGPGLTQVQEDIVSMKAGVLKHQDPGNKWWLESNQRRYVAATGESVIGIVVARLAEYYRVDIGGAQAAILPVLAFEGATKKNKPNLVPGTLVYARISLANKDMEPELQCFNPSSGKADGYGELKGGFVIRCSLGLCRRLLNPETPILRFLGEHFPFETAVGMNGRIWVNSENPQYTILLANAVKNSEYLSEAQCKAMVESLIDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7V8</accession>
    <name>A0A8H7U7V8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_005968</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7V8"/>
    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.54.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="11">
        <location>
            <begin position="24"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2174906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="891" mass="100521" checksum="235EBD3E34E39F23" modified="2022-01-19" version="1" fragment="single">MLSCKLLRATHRTSLPLRRSMKTLSSAEIRTKYLDYFEQKGHTRVPSMVPFKEHFLKPDMAPYKSATSLQKVIRAGGKHNDLDNVGYTRRHHTFFEMLGNFSFGRYDKKEAIKYAWSFIRNELDMPADRLRVTVLNTDEETYQIWKNDIGLPDEQILRLTEEDNFWSMGDGEGPCGPCSEIFWDTRDTTLCDDDRYLEIWNLVFMQNFRHADGTLSSLPTLCIDTGMGLERMALVLQSKENTFQIDQFQHLVSGIRGLLKQQKLPFEEADDPSVHEKIIADHLRSMSFMIGDGIIPSNVGRGYVLRRIIRRALRSGRQLGFKEPFLTELYPYLTDNFGNEWYPELKSRADTIKSIIHSEETIFLATLDKGLGLLESVFSQANLQAAKEILPETAFKLYDTYGFPLDLTTIIAAERGWHINLVEVEKLQEKQKAQGKESWKAGDNLAKGRLAEWRNKQIFPEFTGYDHSLLHQESQIVAIDVNTKGKKPEVLVSIDPCPFYGMGGGQVPDSGLLTLTNGQEWEVMDVFQPYDGGLAMRIQPKDNSTTFSEQLLRDEECLKVGNLVKTNVNLRLRQGAEIHHSATHLLNAGLRKILQTDVVQAGKYSISRSAVEPGRLRFDFTYGSAITPKQLEQIENWVNEMALTDVKTRTLHLPLQKAVDSGAIAVFSEKYSELVRVVEVPEVTKELCGGTHVTSLRQIYPFKIINQSSVAAGTRRIEAVAGDACIDWYRNEYSYIPPVLANLRANSSADLGAKVDKLANALKDTQRQLALYSEKLAQADTGLPILSAIYQDRNVKVHQIDSTMDSNFMLQRANYLKSQEADSIHVLCSPTTVMVALNNKTIPGITAQNVLKQVLTTVNGKGGGKAEIAQARLLDKNLQQSELQAKVLESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8G2</accession>
    <name>A0A8H7U8G2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_004599</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8G2"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="477"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2173225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="505" mass="55444" checksum="AF1E1972BE784D90" modified="2022-01-19" version="1">MGVIGGVLGFASFQKHFNITPAESAQLNGNVVSILQVLSLTFFIPRWLLVSYPKIDAAVGCLVGALSSNLIGDRFGRKLAIMAYSLVFILGGVLQTIGADLSMMYAGRFFAGFGIGANSCLVPIYIAEISPQNVRGKLGTLWQVFIVFGIAISYWINYACKRTISSDDDLLWRLPLGLQCLWAVLVIVGMLPLTETPRWLIAHGHDDRARKALRFLRGQEAEEEFAEISEGLAAEAALGPVKWTDVISKANRKRLFIGCCLQMFQILTGSNVINYYSPTIFKSIGLSGDESDLLATGVYGTMKVFVTLFTAFFITDRVGRRKPLIYGGIGMAICMFMVGAMVKTLPLKADPNAAIGANSYVGIVFIFLFAVVYSMSWGPVVWVYTSEIFPNHIRAQAGSLYTAINWAFNAIIGKVGPLLLASIVYGTYFLFGSFCVIMAIYTFFLVPETKGTMLENMPALFQGNARKGLAHLQDDEENVSENRLNGDNNSVNKFQAEEIERQASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8K9</accession>
    <name>A0A8H7U8K9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Actin-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_005339</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the actin family. ARP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8K9"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10216">
        <property type="entry name" value="ASKHA_NBD_Arp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000205">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000018">
        <property type="entry name" value="Actin-like protein (Centractin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000008">
        <property type="entry name" value="alpha-centractin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2176106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="41706" checksum="B4098A52DE8AF18E" modified="2022-01-19" version="1" fragment="single">VLTNQPVVIDNGSGVIKAGFAGEEQPKCFFPSFVGRPKHMRIMAGAVEGDVFIGRRAQELRGLLKIRYPIEHGIVNDWEDMERIWQYIYTDELKTLSEEHPVLLTEAPLNPRQNRDTAAQIFFETFNVPALFTSVQAVLSLYSSGRTTGIVLDSGDGVTHSVPVYEGFAIPHAIRRIDIAGRDVTEYLQLLLRKSGYNFHTTAEKEVVRIIKEKTCYIPVNPIKEEKETSGKTDDFMLPDGNVIRLGAERFRAPEILFQPELIGQEYLGIHQVIVDSINRADLDLRKSLYSNVVLSGGSTLCRGFGERLLSEVKKLALKDLKIKIYAPPERKYSTWIGGSILASLSTFKKMWVSAEEYSEDPDIIHKKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8N4</accession>
    <name>A0A8H7U8N4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_005445</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8N4"/>
    <dbReference type="OrthoDB" id="289162at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19494">
        <property type="entry name" value="Elp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="364"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2176211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="431" mass="46869" checksum="D99E88A90B294FBC" modified="2022-01-19" version="1">MSFKKRTANAPKLPAGSRISAYNGQLLISTGVPSLDDILGGGLPVGTMLLIQEDQHTSYAQLLLSYFLAQGVACGHHCAIASVDESPRQILENLPWIAEENRSGKEEKESKQESEDDKMSIAWRYQSLKRFDSGVTPRSTPAPISQPNKPAGAGSPEINFCDTFDLTSKIKPEALENAKTTFISPPTCFDDNYDKNHDDYELLMKDLQSVIVDGGFSSLVPAPPGGERNALRIGIQSLASPNWQSKNPEDVLKVLLALRGLLRFSFGAAVITIPSYLYDAAFQRRLQHLCDAVVEIESFAGSISHSAASYAQTYHGFFHVHKVPVLNSLLPSSTKLSVLSADGSNNLGFKLRRKRFAIETFHLPPEGGVSTRRTTPSETKEEKSKSKPDGKTSGSDSSKGRLVSSLASLSMDRSTPVGCGSTPKHKDPLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8Q4</accession>
    <name>A0A8H7U8Q4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8Q4"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051240">
        <property type="entry name" value="Mito_RNA-Proc/Resp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47933">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47933:SF11">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="180"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2172402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="557" mass="63171" checksum="D196689788E9FED5" modified="2022-01-19" version="1">MLARNIVRSQCLSSFRRQYATGISAQQNRKTFKSAETQAKSLGKPTGRLQQDPYYLSKKITKLLNKDSLDEAVTAVKTSPISLQNEVVWNQLIAKHAKQGRSGAAFSLVTEVSTAPNTRKSHDAPYADHFLTFQMKRRGFKPTDQTFTSLLVALSMNPGDNVLQKANDLHTSLSEAGQMSKYHYNSLLQVYARADAHRQMMRIFNEMKSTATRPDAFTYNIVLNSFARNDEGDYNELMEVWWQLQQQVREDSERAIGQSKTLSQSSDLKTDHRLLAALLQGIRRTSTLSKQLYTGIATFDELHHLNISGRKSEHPDLNSQNSLQPNSISFHALLKLLNSARKFGMADTYIKSLYDQIDPDTPTINAVIAIRYSQKRYTEAVNLLDTMNDRAMAPNASTFDMLIRCCGNMYKGRYASDPVVWETMSKVLNRHATEKADRIKKELPLKDLELSSKSCTEILRIGRAAAGGTNDITRRREIYNLTVSCIESQRWRRAVSKGWNERNDMLAKWMVDAYTVLLDTSDSQPVSKDTLETWRENLELAEKLVKKQASPSSVSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U928</accession>
    <name>A0A8H7U928_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U928"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="81" mass="8944" checksum="BA3D30D7D817181E" modified="2022-01-19" version="1">MESAVAQEYMVEMENASAHIQDLLLVQMILIVSVVVVAQTMSVVVERAVEGQDVVLEGAYSNQLDILAASHYTIIYIYNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U992</accession>
    <name>A0A8H7U992_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U992"/>
    <dbReference type="OrthoDB" id="3360610at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046491">
        <property type="term" value="P:L-methylmalonyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07267">
        <property type="entry name" value="THT_Oxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000034">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000039">
        <property type="entry name" value="Trihydroxytoluene oxygenase (AFU_orthologue AFUA_8G02470)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051785">
        <property type="entry name" value="MMCE/EMCE_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048:SF3">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="46"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="192"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2173122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="351" mass="39512" checksum="74E907C2F8F500C1" modified="2022-01-19" version="1">MTHNLVLPNQHAAVSDVEAAEGTGSSVADFRKEFDIDVEKQVRLVKISHMRYQHPNLEEITQFLLDFGMTIAKKTDDKIWFRGYSTDQYVYYVQKGPKQFLGGTYEVESYLDLEKAEKLAGASAIEELKDAPGGGYFVSVIDPSGFPVNFLYGQTPAAKGKTPAKVSANYTDDKPRKRVFQRFTPGPAAVHKLGHYGLSVTDLKGQLEFYFKNFNLVPTDYLYVEVEGVKHRVSVFAHIDRGDDYVDHHTFFLSHGATNHVHHSSFEVHDFDTQELGHQWLASKGYKSVWGVGRHILGSQIFDYWWDTTGNMIEHYADGDLVNDQTPINNVPAGSESLAAWGPELPKEFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9F8</accession>
    <name>A0A8H7U9F8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U2 small nuclear ribonucleoprotein A'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_004691</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the U2 small nuclear ribonucleoprotein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9F8"/>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000026">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044640">
        <property type="entry name" value="RU2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552:SF6">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2173317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="253" mass="28665" checksum="1AD39CF30BF957A4" modified="2022-01-19" version="1">MKLTPDLLSNSISRINPLKDRELVLRDNKISAIENLGVTKDLNDAIDFTNNDIRQLGNFPRMLRLRVLLLANNRIGRIDSQLVDYIPNLTTLILSNNLIQELGDLEPLTKCAKLEYLSLLDNPVTKKKYYRLYIIHKIPSVRVLDFKRIRKAEREEAKELFKSEEGKDNELAISIGEAKTKTFDVGDGLDNDDHKKSNAPGLSAEEQAKIKEALKNATSLDEMQRLENLLKSGHLPGDKRKGAAADDMEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9J3</accession>
    <name>A0A8H7U9J3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9J3"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF152">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="336" mass="36587" checksum="89387B4BC7C66CA6" modified="2022-01-19" version="1">MKLDRQTDFPAHQIVKLHVEPQNLQGKTIVITGGNSGLGLASAKSIAKMNPSKLILACRNLDTAAEAVEAIKADGFDAVEVWQLDQSSYANVKAFAKKYNESGLDLDVLLANAGVLPGKPAGKPGLNADGNEEILATNHMGAALLALELLPSIRRTAAKAKDNQLPRIIIVASDVHYWAELPAAKEEGNIIKTMNSEKTWSNVLDRYMDSKLLNVFFANELANKLKQSNVPEDKKIVVTSCNPGLCMSAEDAANPNHPIPAPLREIARDYTEGCKTHVFTTVDPSVNKPGQFVFYSNCAPLETADITLGKDGDVLRERVWRDTLEVLGVTEQQYQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAH1</accession>
    <name>A0A8H7UAH1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleoporin Nup54 alpha-helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_000125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAH1"/>
    <dbReference type="OrthoDB" id="6162375at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024864">
        <property type="entry name" value="Nup54/Nup57/Nup44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025712">
        <property type="entry name" value="Nup54_alpha-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000:SF0">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13874">
        <property type="entry name" value="Nup54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup54 alpha-helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="345"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2172778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="496" mass="52748" checksum="169C2270A6BFDBF0" modified="2022-01-19" version="1">MAFSFGAQPATSTTPSFGGGFGTNTAGSFGSTAPAPASNTFSFGGSSAAPATSTTPSFGFGASNTAPATSTASGFGFGANASGTSTAPAPSFGGFGATNTATSQPANAGGLFGSTQGTGGFGTNNSQPSMFGSNTAATSSAPSLFGSNTTATSTAPSLFGSNNTASAPSLFGSNTAATSTAPSLFGGASNTTSLFGNTSGTSLFGSNAAKPGLGGGMFGGQQQQPTIGANANAQQQQNQQVWQYLSQQEQSAQQLNQRLLPGQHTNPQYIWQSLALIKSEWDPNSTNCKFKHYFYNIVHPSEVQRFTKPPNEEDKAWEMAMKNNPDPTCMVPVRAVGFEALRTRIETQDKQCQAHKIKLEQLEQKIKEVRRKHNIETVVKLQEYKRRHVDLTQRVIQQPVSLTLLTFGVKKFLKYAQILRNKGFSIENEEETLRSKLETVQSRLQQSDQFHGKLNQLWAQLQLVRESSRIYDGQAGDQGWSTVSEKDMATISKVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAN9</accession>
    <name>A0A8H7UAN9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_000066</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAN9"/>
    <dbReference type="OrthoDB" id="2098326at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03189">
        <property type="entry name" value="GST_C_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000156">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01150">
        <property type="entry name" value="Main.1:_Beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="11"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="98"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2172719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="232" mass="26551" checksum="13EA29C70CBF6F49" modified="2022-01-19" version="1">MSESTTTKIPPTPIILHHLNNSRSQRILWLLEELNLNYEVKKYQRGSDMLAPAELKEVHPLGKSPIITDGPHTLAESGAIIEYLVNRYGDGKMKPTNGSDEQLQYTYWLHFAEGTLMFPLLMTLIFMEVTKQTPFFVRPIASAISSQVHKLFIDPNLQRDFKYIESHLEKNEWFAGPEISGADIQMSFPLEAASMRADKFIGPKTKAWIKMIQDRPAYKRALEKGGEYSMNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBW4</accession>
    <name>A0A8H7UBW4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">cAMP-dependent protein kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_007887</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBW4"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12098">
        <property type="entry name" value="DD_R_ScPKA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000039">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000006">
        <property type="entry name" value="cAMP-dependent protein kinase type I-alpha regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0114">cAMP</keyword>
    <keyword evidence="4 8 9" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="181"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="304"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="52"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2177230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="435" mass="48991" checksum="4A202E8A7F70D983" modified="2022-01-19" version="1">MAFATSNINNSSVAKEYEGILNDLNKAVYENQPEDVLQFCYNFFGTRLEQERSHSRQQATHSAQSKDESKDQPKDESKADDAGHPHDLEGLKFPPVAKTEFVDQGHLTDSSDEEDLDDEARDSFGSMPALEPGAGHNRGRRTSVSAESIQPSQNQNFVKKVIPKSQEQRDRIKRSVKHNFLFKNFDDEQYQDVVNAMEEKRVPANTTVIEQGGVGDFFYIVESGTLDCFITKDGGSPHKVTEYNAGGSFGELALMYNAPRAATIKSTSDCVLWALDRVTFRSILMENTSRKRKMYEAFLEEVPLLRSLEPYERHKIADALESSYYEDGDEVVKQGDVGDNFYMIESGKAIAYKLAEDGTKQEVYRYEKGGYFGELALLNDSPRAATVVAVGRLKCATLGKKAFTRLLGPVRDILKRNSENYNAIIEKEREHDQHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCC9</accession>
    <name>A0A8H7UCC9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketosynthase family 3 (KS3) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_005771</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCC9"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF21">
        <property type="entry name" value="NON-REDUCING POLYKETIDE SYNTHASE AUSA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="4">
        <location>
            <begin position="62"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2174713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="553" mass="59789" checksum="CC3BC2E0028112AE" modified="2022-01-19" version="1" fragment="single">VAKQIAIDLAQSSTKDVNVLAIGPSTSTANQVVEVINRSGDVRAKLVDFTDGHIKYKADPFEGKVAVIGMSCRFAGANSLEEFWQVIENGLNMVKEVPNYRFNINDYYSKDRSKPNSLYTKWGNFIDCADKFDPRFFNISPREAINMDPQQRVLLQVAYEALEAAGYTPDSTPSFDRNTFGCFLGASTNDYTDNLCRNIDAYYATGTLKAFLSGRISYYFGWSGPSITMDTACSSGLVSLHYACQSLLTGECNAAIAGGVNIITSPDLYLGLGRGSFLSPTGGCKSFDASADGYCRGEGCGLFVLKRLSDAIADRDPIIGTISASAVNQSGTTHSITFPHANTQAELYKKTCDIAGLHPHEVSVVEAHGTGTQAGDPIEMQSIRTWYAQKRSASNPLYVGSVKANIGHAETASGAAAAIKVLLMLQHKKIPPQVGFQRLNPKIPPIEPDNIVISKTCQDWKPSKLVASVNNYGAAGSNASVLIEEAPQNYGRIGTDPRSAIVTLSAKSVDSLEKMRKNLLSFLEANPNAPLQDIGYTTTARRMHYPHRLAVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCT4</accession>
    <name>A0A8H7UCT4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_008456</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCT4"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="37"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2180876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="325" mass="37466" checksum="63A388F764BFDCCF" modified="2022-01-19" version="1">MDKYNTNDPTTYRHCTVENLNGIRIHYIDENSSSQKVLLLLHGFPEFWFGWREQIPFLVSKGYRVIAPDLRGFGETSCPESAEVYGHKTVSDDLVALLDYLQIPTVTVVAHDWGGAVAWRFTQYYPERTLAVAVFNTPYFPPNKTYVPLEKVVEALPNFRYQMRFCAADCDQELDADPEAFFKRILRLHTEAAGPLYDAENDSIIRGRPQLERSKAITEEQLKYYVEQYKRNGFHGALNWYRTTKVKYEESKDLDPIIKHPAMMVTASDDKALPPSMASGMHKFIPNLEMQHIENAGHWVLWEQPAECNRLLDGFLSKVYGNSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEQ8</accession>
    <name>A0A8H7UEQ8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEQ8"/>
    <dbReference type="OrthoDB" id="2412974at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2180260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="88" mass="10298" checksum="416AE16AB3A89DD9" modified="2022-01-19" version="1">MAEVSILQLALLVGTMTILMVAGVCWCFCCGTCVGRDLLRMVGADRFIPTSHRYHRHRDYHMPTMEYDIHEQQWEMNPYNYNNSQLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UF24</accession>
    <name>A0A8H7UF24_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UF24"/>
    <dbReference type="OrthoDB" id="2326968at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034053970" evidence="1">
        <location>
            <begin position="19"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="160" mass="17515" checksum="02A9FFCBC6089417" modified="2022-01-19" version="1">MIKLILSILVALALCVSAAPAKTTPMAGTFAIHFHSYLDGEVVLVKNDVANKPGSFLYFHIKEGLETNATYHDYKIQFRNGHDCKHVMGQVVDVDTPPFKINAQGGTDAWCIDKSLDMTKVSTVQVLYKNEPVACSPLVADPNFKIKHPTKVNACIRGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFB7</accession>
    <name>A0A8H7UFB7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFB7"/>
    <dbReference type="OrthoDB" id="10485383at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="189" mass="21251" checksum="EDF547C689695694" modified="2022-01-19" version="1">MHYSYLPHKCSKVYDIFNIKLNRPLKKCSVILNGIPRDAWICNSAQGNVLFQLTLGNFGLVNLEIIGMDEYDELYGVSGGNNDSYYGNQDIYGDDQDNSQSYDPEKATLYSNQPNKAEGQSQQEKSDSNPTYDQQQQYYGGDSDNTRDAPQQREYDQTHDQDQSNQSVGGQEEHESHPSVASAANQDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFI5</accession>
    <name>A0A8H7UFI5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Translocator protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003236</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFI5"/>
    <dbReference type="OrthoDB" id="8841220at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033013">
        <property type="term" value="P:tetrapyrrole metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.100:FF:000001">
        <property type="entry name" value="translocator protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="entry name" value="TspO/MBR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057:SF0">
        <property type="entry name" value="TRANSLOCATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005859">
        <property type="entry name" value="PBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2177983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18401" checksum="E95C7448337D59BC" modified="2022-01-19" version="1" fragment="single">LPVSLGVPLVGGMAMGLITKSSVNTWYKTLDKPEARPPNWMFAPVWTALYAAMGYGSHLIANHAAYSPVPEIRDLANLGLTLYYSQLVLNFAWTPLFFGVHKVKLAAIDCGLLTANVAAMIFTWWKVDRRAAQIVMPYLGWSSFATYLTISVYQRNFAGRPRKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGD1</accession>
    <name>A0A8H7UGD1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_001745</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGD1"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1690.20:FF:000003">
        <property type="entry name" value="Mitochondrial inner membrane AAA protease Yta12, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="315"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="734"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2178898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="759" mass="83572" checksum="459C03A29C3C2E1D" modified="2022-01-19" version="1">MARFNARIPSRAVLRTENSQIGHFARQRRPYSSEKDQPKKHNEQNAEKDSKSSDNGKPFNIPKGFEGFFGRKAADGSAKRGADEAAKQHAKKASGEVPKPPPGGPKGNGPPEIHLNLNTIVPTLFGTWLLWKMTSPTDNSREITWQDFQTEFLDKGLVDRLMVVNRNRVKILLRPEASSIGASPQAVYYFSIGSIDNFERKLDDAQRELGIPSSERIPVAYHDEISLGSTLLHFAPTLLLVGVLYYMTRRAGGAGGAGQGLFGIGKSKAKMFNQETDVRTKFKDVAGADEAKEEIMEFVKFLKDPSHYERLGAKIPKGAILSGPPGTGKTLLAKATAGEAGVPFLSVSGSEFVEMFVGVGPSRVRDLFATAKKNAPCIIFVDEIDAIGKARGKGGQMGGNDERESTLNQLLVEMDGFNSNEHVVVLAGTNRPDVLDPALMRPGRFDRHIAIDRPDISGRAQIFKVHLRPIKTTEDIERLSNKLAALTPGFSGADIHNVCNEAALIAARHLKNEVTEIDFEHAIERVIAGLEKKSRVLSPEEKKTVAYHEAGHAVAGWFLEHADPLLKVSIIPRGVAALGYAQYLPKDQYLYSTKQLMDRMCMTLGGRVSEHIFFDTITTGAQDDLSKVCKLAYGQVATYGMNPVIGPLSYQDPNGQESFQKPFSEDTGKLIDGEVRKLVNVAFERTHKLLTDKKAEVEKVAQLLLTKEVINREDMENLLGKRPFKEKTVYDEYVRPKPSSAPPPFPEDVPEPPVTPDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGL4</accession>
    <name>A0A8H7UGL4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD repeat-containing protein 61</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_000944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGL4"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051510">
        <property type="entry name" value="SKI8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090:SF1">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="12"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="139"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="181"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="223"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2185031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="32745" checksum="65434E41173D4740" modified="2022-01-19" version="1">MPTTYIPTIVKDDAHREGIWCVAWAPSSDLVLTGSLDNTVKCWNGTTGDEKHILEGHETGIISVDTNKQGTLAVSTSIDSNIRVWDLENDGKLLHSINAPPGQAWTAKCSPDGAFVASGSHSGNLNIYKIEDGSQASSLSTKNQFIMSTAYSSDGKYLACGADNGTIYVFDVEANHLIHTLQGHALAVRTLSFARDNRTLISGSDDKRIHIFDVQHGKVAAALTGHNGWVLSVASNPDTSKQQIASSSSDKKIKIWDMGLHQAIETHEVHTDQVWGIAWNVEGTKLVSASDDKSVKWFASSGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGL9</accession>
    <name>A0A8H7UGL9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_000959</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>precorrin-2 + NAD(+) = sirohydrochlorin + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGL9"/>
    <dbReference type="OrthoDB" id="1721126at2759"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.110">
        <property type="entry name" value="Siroheme synthase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3280.10">
        <property type="entry name" value="Siroheme synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330:SF1">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="8">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="7">
        <location>
            <begin position="161"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2185046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="247" mass="27752" checksum="C8C1F28C65744D3E" modified="2022-01-19" version="1">MTSYAPIRPGGSLILAWQTKGRKVLIVGGGQVAAGRIVSVKEADAQVTLICPEKGLCHEVKHRIHVDKVVNWVDRWFQDSDLDQHYDMVLTAIDDHEESLRIGQICRERRIPVNVADVPSMCDFYFMSQHRDGPLQIAVSTNGQGPKLANMIRQKIASSLPQGIGETVRRMGALRAKVRQWDPEISNSGPRMRWVTKLCEDWGWSGMARLNNLSQDEEKDMYTSLQKAYETGEVPPVDTVLPEEKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGP9</accession>
    <name>A0A8H7UGP9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_002093</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGP9"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000013">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000009">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="51"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="250"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2179243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="465" mass="52363" checksum="9D9D24B36538626E" modified="2022-01-19" version="1">MREIIHLQVGSISFQPIILIGTKFWETISQEHGIDANGAYIGDNPLQLERIDVYYNEGNKGKYVPRAILVDLEPGVLDSIRGSKMSKLFHPDNYIFANNGAGNSWAKGYYTEGAELVEPIMDVMRKEAENADCLQGFQLAHSLGGGTGSGLGSLLLSKIREEYPDRMLSTYSVFPSPQLSDTVVEPYNEILSIHQLVEHCDATFCFDNEALYKLCQNSLKIASPDYGNLNNLIAKVMSGVSTSLRFPGQLNADLRKLCVNMVPFPRLHFFIVGIAPLVAEGSSQYSVQSVRELTTRMFDSKSMMTEFDIRQGRYLTAATMFRGKVSTNEVETAMLNMQQKNSNWFVEWIPNSVKTSLCDVPAIGVEQSATFIGNSTAIQSLFTRANDQFTPMFRRKAYLHWYTNEGMDEMEFTEAESNMHDLVAEYQQYQDAGVDDEIVDGEMEMDEDYLNEGHDKVPLEEEELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIB0</accession>
    <name>A0A8H7UIB0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_003902</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIB0"/>
    <dbReference type="OrthoDB" id="93019at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT XANTHINE DIOXYGENASE XAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="17"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2180114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="378" mass="43163" checksum="3C68209B05D2A383" modified="2022-01-19" version="1">MQFRELQLPSTQTGVDFGIELVDCDLENLTDEQFKEIEKAVYSHQVLVIRNQSHVSPETQYRLTKRFDPEVDTYGHGTSHQSKKSVIARDLSPLPGVPQVQLLGHGTVHNHHGIEERELHHPSHHSFHQTQLSEEDEKAGKTRFYRWHMDAALYELNPPLITTLFAVKTPEHRREEVVYDDGTNQKLDVQLGTTAFISGAHAFDILSPEMKDLAFRTQVKYAAHPYLWISKARAHSTGLGIVSEDRELPKDELPPIKEDAIKIYPMLWKNPVTGKIHLQVHPCAVEDLIIDGKPVGDLKKVREMLYQIQRPAINPENVLAHEWEDGDMVIFHNRGVLHSVVGSLRDTDKRVYHQCNLASAKEPQAPTEEDRKPYVLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIJ7</accession>
    <name>A0A8H7UIJ7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_000324</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIJ7"/>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13437">
        <property type="entry name" value="SPFH_alloslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="109"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2184415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="344" mass="37992" checksum="D3664AE809DB1FA2" modified="2022-01-19" version="1">MSRPQHPDQPLELTDRSSSASYPRASNMHADNSEAGLGQQGLQPTYAMELGLETIPHVRLLWHNDEQVFLCNFSIDSESVNNMLCPLLCSCSILDGIGACVGFFGAHVNRNVFILIGNVGLVSRFGKFYKCVDPGLIKVNPITEKVRKVDIKIQISEIPEQEIMTQDNVNVKIESVLFWHIIDPYQSQYAVTDVERALTERTQTTLRHILGGKVLQDAIENREAISGEIQDVIEPSAKVWGVKIESILIKDIQFSPELQASLSSAAQAKRLGESRVIAAKAEVDSAKLMRDAANILNTPAAMQIRYLETLSSMAKNGQGPKTIFMPLESSNRMTQNIGQPSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIN6</accession>
    <name>A0A8H7UIN6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Pyruvate kinase</fullName>
            <ecNumber evidence="6 17">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">INT43_000444</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="6 17"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIN6"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000025">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 17" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0630">Potassium</keyword>
    <keyword evidence="15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="18">
        <location>
            <begin position="27"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="19">
        <location>
            <begin position="387"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG2184535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="508" mass="55380" checksum="19B43F21454356AE" modified="2022-01-19" version="1">MTTNTTITSSLQWVSQMNVDVEPKAARKTSIICTIGPKTNNVEKLTALMEAGMNICRLNFSHGTYEYHQSVIDNCRAAAKSRPDHPVAIALDTKGPEIRTGNMKDGVEIPISAGHELIITTDDKYADASDDKYMYVDYKNLPKVTEVGKVIYVDDGVLSFEVLEKASDHVKARAINNGKLCSKKGVNLPMTPVDLPALSEKDKSDLRFGVQNGVDMIFASFIRTAQDVKDIRKVLGDDGQHIKIICKIENHQGCLNFDEILGETDGIMIARGDMGIEIPCERVFIAQKMMIAKCNLAGKPVACATQMLESMTYNPRPTRAEVSDVANAVLDGADLVMLSGETAKGNYPLEAVNTMAATCCLAESVLSYPVLFNEIRGLTSRPTETTETIGSAAVAAAMEQDAGAIIVLSTSGSTARFVSKYRPSMPIILVTRNEQTARQSHLHRGIFPFVYKGDKDANWQVDVESRIRHGIEQGKKNGLLKSNEPIVIVQGWKGGLGNTNTIRVLIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UK32</accession>
    <name>A0A8H7UK32_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UK32"/>
    <dbReference type="OrthoDB" id="5598695at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000087">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF21">
        <property type="entry name" value="SWIRM DOMAIN-CONTAINING PROTEIN FUN19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIRM" evidence="2">
        <location>
            <begin position="222"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2184657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="316" mass="35924" checksum="8214F5AA4BE861E0" modified="2022-01-19" version="1">MTTTTSLLSPPLTPTSDNQSIAEDVPWAVDHKPSSKPNLPIGNYTKASSPPELNARKSRNKSLIRYQQAMVMPQTPRPKKEYIHLNHLISVKTSPSSSAHSRKSSRPRRSLQRDERSDQKVFQLRVYDTDPSKLLQCSSRTIQPPMIKSDSADEGSNSEEEQVIAQMKRRRALSDANESMSKKCKTDAAMAFDRVHVEESDHEFFDPEWIPSYQVFDQRPPVRVVWKGSPLQISNMPYYDKLHLGEVNIASTLRLTPEQYIKCKRTLIQAASRYESQGVPFRKSDAQKLCRVDVNKTSTLWSIFGKLGWMGNGCIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UMU7</accession>
    <name>A0A8H7UMU7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UMU7"/>
    <dbReference type="OrthoDB" id="2377025at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="194" mass="22138" checksum="E4E0E369C4E54E36" modified="2022-01-19" version="1">MPTADHFSAHPETFDSIYRHDNHKKYSPMKDINMNFPHNNTYTTSFDVAEAARTKLAEHYEFSRTDNSIRRLVLLSNMLKSVSQQPSDRGTATPMTALATDPEKQKMAQSWFDSCIDDLIQEDDSDQPTAPILYKPISSAVNPEWLPTFEPIELDDDLDEDDESLIDETDIPQLCSSASSDDSFWSNDDLYDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UPC2</accession>
    <name>A0A8H7UPC2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_002567</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UPC2"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF745">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="110"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="230"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="270"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="310"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="350"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="390"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="430"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2186129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="512" mass="57922" checksum="1BFC6D4AFBE00D61" modified="2022-01-19" version="1">MSSSPPPKTATGSPLSLKKVWRYFHQSLHSSSSKSQHHREFRTIATSSSCPPHGSRSFTNISGRNSLSPTKNLTKNFSLTVVPVDQTSRIDEGFYQVAKPSFNDKTTATIDFLTQLPHEIACHILMFLDDVRCLVSASAVSKAWHCLCTDNLVWKQSYTLNKSWMRTLPPVGFLDYRDLYIRRMWVADRWKKGAVTTSYLTGRLTNYTIETNTIFADPPVCHSTLFLTLRLGHTDSIYCVQFDAEKIITGSRDRTIKFWSMKTRKCIRTLTGHDQSVLCLEYDKDTMISGSSDCTIIVWCMQTYKQVKRLRGHSAGVLDICFDDKYIISCSKDTTIRIWDRTTGDWLRSLQGHRGPVNAVQLRGNKLVSGSGDALIKMWDTETGECIRQFSGHMRGLACVQFDGKRIVSGSNDQCIKVWDAETGECVLTCEGHTDLVRALHFDDDRIVSGSYDQSVRVWDIRTGACLLNFQSGHSSWVFDVMLSATKIVSVSQDKTILIMDFAHDIELKHIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UPH9</accession>
    <name>A0A8H7UPH9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S acidic ribosomal protein P2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_002717</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UPH9"/>
    <dbReference type="OrthoDB" id="1227494at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2186279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="11281" checksum="40CE8190822F7D87" modified="2022-01-19" version="1">MKYLAAYLLLTAAGNTTPSSENIKEVLSSVGIETNDKDVASLLSAVEGKDINELIAEGRTKLASVPTGGAVSGGAAAGGAAAGGASEEAAAEEKKEEEKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCK4</accession>
    <name>A0A8H7PCK4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_009038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCK4"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000043">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF18">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E HOMOLOGOUS PROTEIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="254" mass="28841" checksum="466402D676ED1399" modified="2022-01-19" version="1">MDTAQSVDWTSSDVSSQYLENIVTAGKRSNTSNSISLTPMTPVFSSATSTGKPLKSSSEGLTIKLLDQNTHEDQRHPLRYTWVFWFMHRPPGAKITNYESGMKKIATVSSIEDFWAVYSHLKRPHELPNISDYHMFKHGVRPVWEDAMNVNGGKWIVRLKKGLASRYWESLTMAIIGDQFDVGQEICGAVLSIRGAEDILSVWNQSAREGRTNLKIRDTLKKVLNLPPDTIMEYKTHNDSLNDNSSFRNTDIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDL4</accession>
    <name>A0A8H7PDL4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_008140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDL4"/>
    <dbReference type="OrthoDB" id="43122at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700">
        <property type="entry name" value="YALI0E22418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="3">
        <location>
            <begin position="145"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="233"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2171760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="656" mass="73913" checksum="07DE8C601FF7752D" modified="2022-01-19" version="1">MQSSDDDSDDMPVALSHQLRRTKQQGPPSQTDRRHLARAKTMNSSSTSRNQGNLTRSNTEHHRSRGHREERPVPESSRKVDDDNNDDSPVRGRGTERNDRGAIANKPGKIRTHDVRNIQADLHRLQLASVQKIASRIYVIDSSKYVNLQLTSLMTTAMVLESLRERAVIDQEQSWTLFELANKVGVERPLRDWEIVTDILSTWDQDEKNALLVKKYSYKPTLTPESVLGKNEFVPPSGHLYFEYKRGKWHKRSFTVKGNGIYLSRESKKTGDAPIVPLANVDVYTLTIPIKKAPTPFGFILKAQQKARIFENPEDFVFSFCAEDMEQLKLWVLGLRQNLAFYASNPARLLSPLKPLELPPLPQSVVHKVLSPSENTPLIDQQQLLNSDPEPKPIPSVSSEISKGSASKIHRSATLLERSMQTERIDDGNKVSVRRYKSTRDIKSSSRQAEPLVVGNDVETDYRRQPDMPPAKPIMLRPSKSLGTRRTANSSRHQDHSADVPRIGRSEDRRQLDKGNISATNERYSPIQPDDGSSLLKLNENFQFSDGSLLQQASDTVVPRGRSKSISRDPRRVRSQSRPRHASVSDNNEQGSSATRSKSLRRKPTVKGANDREPEAHPPLPKASGEDGPLLQLDLTPEASHTKALRDRQVKPLITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDN1</accession>
    <name>A0A8H7PDN1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pleckstrin homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDN1"/>
    <dbReference type="OrthoDB" id="2407685at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pleckstrin homology" evidence="2">
        <location>
            <begin position="68"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="302" mass="33310" checksum="BC0AF4FCB855B7D8" modified="2022-01-19" version="1" fragment="single">ATTVAHTAPVAHVPSIPAIEVDEPVNETSNISMSASSTTATLPSVTRTSDDDSIDEASPSSQADTRYCKNGFVIRKHLLESAETKARHRNWSEYYLNIEKGHICTYYVTGVSLSDNVNRRSVFRLSGINGVPNGNHSSVALSSELAPTSNIGSSWRATSQIADKISLLHALANALPAPGYNRQRPYVFALQLPNGGVNLFQVNSTEEAHAWVDCCNYWAARQSNVSLAQGVINMEYGWSERALEEDISNESINLYDWSPPTPSMTASHLDEFSQLNQLRKHLDELNDEMDEHCTLDKKIESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PE95</accession>
    <name>A0A8H7PE95_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras GEF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_004862</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PE95"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="164"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="330"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2172320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="66383" checksum="F76322009D7531CB" modified="2022-01-19" version="1" fragment="single">DLSLDKMNGNIPSTKGINRKSDGSRDSFASALHTSGLGGLDMDSQPLEPFTTEAELNKILEDDDAFSEDSLDSQGEFPNSKVSARSSMPNLPPENHTEIIAQIQRSITSPDFETAPPSTKQDKLKKFFGEEAAAEAATAGKSTINDTPTFLGYDYDPAEIVVNMEGDVKGGTLTALTERLTSHKYLDTNFNGTFLLTYRSFCTTDELLGLLEARYNLQPPNDLTEEQLQLWYEQKLKLVRLRVFNVLKNWIETYFIDEDNMVLERLQRFANITMRDTLSFSADQLDKLIKKRQETDDQGGLRKMVLNLGVQAPAPIVPKNMKRLKLLDIDSLELARQLTILDFKLYSSIRPIECLNKAWSKDDDRGDIAVNVKSSIEFCNQVTAWVTDTILSQNEIRKRTNVIKYWVQVAERCRQLNNFNTCMAILSAFDNSAIGRLRRTWDIVGARTQHTLAYIRKLMGANKNFTEYREIIHSINPPCIPFLGIYLQDLTFIEDGNSDYLKKSKSLINFSKRMKTAEVIREIQQYQSAPYALEPVKEIQYVIHLNLQNSRDEDTLYALSCALEPREREDEKIARLLQESGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEC9</accession>
    <name>A0A8H7PEC9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_004934</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEC9"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034673327" evidence="4">
        <location>
            <begin position="19"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="92"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="253"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2172392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="357" mass="40192" checksum="5E9060D377F0CBDA" modified="2022-01-19" version="1">MWKALLSLYLFLLLEANAVVRKYYIAAIDVDWDYAPAHFDKYNDKPLAESPAAEYTVRKKDRLGSTYRKAVYRKYTDSSFSTMMTPDASFGLLGPLIRAEMGDQVRIHFYNNASKPCNLHPSVPKENSKIPHFEAIEPGKGHIYVWDVDSLDDQAMGNVSSTLWAYRSLTDPIQDMNSGLIGPLVVYKPGMLSGTPNAYPSGIDREIFTLMMTTEETRSKYFMESAKAAGISEDKLKELVDDESFVESNRMYHINGFVFNNNPGIHLPYGSNVRWYVLAMGITTEDSHTAHWHGGTLLKHGHRVDVVDLLPSTFEVLDMVPDNAGQWLFHCHVASHLMNGMSIFYQVDEPETGGSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEF2</accession>
    <name>A0A8H7PEF2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEF2"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="2">
        <location>
            <begin position="125"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="125"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2172412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="361" mass="41111" checksum="44A3E2A0E0563DC7" modified="2022-01-19" version="1">MYSSSSKQDKTISKMARAIKSKPAHYDTPFDSQSINLELQLQDLTLEMAVVKGVPGFKTCSGKGFISNRQLMDIIDDGSQHQDIGLGYRVPTWRLLQMVLACLNKLSVSVPSNRRRKKHKCYQKRPKPFNAYMHFNRTIRMKISTLMPDYKQKEVSKLTGALWKASNANTKAYHRCAAAKENKLDHHITLCKHHICPQSLHYKRSGSFVCFCNGCWCLSKLKGDITEVLNLKWISNMDPHVFRSVSDTSSCDEVSISRDTSFFDSLECSIGQEDCSSDLLSWLDSWNTTERLDIASDFVDWSSIMSDLSIYIGRIQDQHRLQLLESIILSDSDVNNAFKLPSADSDLWVPSIQAETKLEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFV2</accession>
    <name>A0A8H7PFV2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_004560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFV2"/>
    <dbReference type="OrthoDB" id="285793at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003889">
        <property type="entry name" value="FYrich_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003888">
        <property type="entry name" value="FYrich_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040092">
        <property type="entry name" value="TBRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22715">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR BETA REGULATED GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22715:SF0">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR BETA REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05965">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05964">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00541">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51543">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51542">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="372"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2173186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="413" mass="45914" checksum="BD70E0CD4D969B87" modified="2022-01-19" version="1">MTNENTVSQDPATSADEQEITEHQYRKLKRKLKEYMEVNCLAGYSLRAQVLQINKSISDNLSRSMYKIKTLRFERNILLDKLQSVESTHSDSHAEGTSEEEGTAAYSDLEVSSIASLKASFKASRKASPYHSKSTSAGTKRKRRNSASTTVISAPPKRNRNPNVKVTTRRIQPVPRDENGHPVMPLQIGVLTVQDLGHVVWDRPGFHTERYIWPVGYTITRSYPSMIDANNNTTVRATILDDGNNQPLFRIECEDCPNDPIIANSATGAWTAMVKRANEVRGILRTNSASGPDYYGLGHATIASLVQELEGADKCQDYVWQQFEAMQDRAAKGVMKACAKKRGNLEKLGSVKYRMVQKAGSAVPHADAIAMDNESVQDELVDEDADMEPPSSLAAGEEEDTDELDENDDETVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PG00</accession>
    <name>A0A8H7PG00_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_004635</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PG00"/>
    <dbReference type="OrthoDB" id="3640at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08066">
        <property type="entry name" value="MPN_AMSH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000033">
        <property type="entry name" value="AMSH-like protease sst2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044098">
        <property type="entry name" value="STAMBP/STALP-like_MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947">
        <property type="entry name" value="AMSH-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947:SF13">
        <property type="entry name" value="FI19924P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="241"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2173261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="414" mass="46332" checksum="F5555A92CBD08483" modified="2022-01-19" version="1">MIVTSENPGSAPLSLLVTNDCRVPSLGLTELPKHAKYQNPDNKPMIKTIKQNCLEALDALEQIKPKLDTRYNEYVQQRRKEQAEARKRQEEQARQLKLRQSAYVEDKTQVDEERAPQSWSLQDELRGVVGVGSQAEAMQRQAPSAAPNFQYPGVLQRNTSDNYTYQLNTSDAVVVSPSLPGKEPLSPANRNAIVPPLPPKLQLENPPQLPPKVEIDSVDNLPIDLEDYSGATTESGSPLRTVNTPLSILDRFLDIAASNTRKNLETCGILCGRLKANQLTVTTLLIPKQTSTSDTCTTENEEEVFEYQDRHDLLTLGWIHTHPTQSCFMSSVDLHTHCSYQLMLPEAIAIVCAPKHNPNYGIFRLTDPPGLDVITRCREPRAFHPHPDVAIYTDAMDLGHVRMSQLPFDVVDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGN5</accession>
    <name>A0A8H7PGN5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ras-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_005045</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGN5"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2173627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23823" checksum="286E66FF3EBE4FE0" modified="2022-01-19" version="1">MSKASFLREYKVVVVGGGGVGKSALTIQFIQSHFVDEYDPTIEDSYRKQCVIDHETALLDVLDTAGQEEYSAMREQYMRNGEGFLLVYSITSRMSFEEINTFYQQIRRVKDRDFFPMVLIANKCDLEHDRQVSSHEGRDLAKSFGCTFIETSAKQRINVDEAFYHVVRDIRRFNKEQQGGGGPRNGYGGQQFDIDDENASSKCCGCTLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGR8</accession>
    <name>A0A8H7PGR8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_005031</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGR8"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004677">
        <property type="term" value="F:DNA-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05172">
        <property type="entry name" value="PIKKc_DNA-PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037706">
        <property type="entry name" value="DNA-PK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF68">
        <property type="entry name" value="DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="297"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="10">
        <location>
            <begin position="679"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2173613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="711" mass="80457" checksum="FA154B7B01757878" modified="2022-01-19" version="1" fragment="single">STDGQTNPVPFDHSSYANAVINGVFTAMDSGISEASELFPRLLELIDDYPETSSYFKSRSSQLSAIWLLLPWLPQIVAVMDKSVASSVNPLVTAIAQVYPNALYYPMAISREHYRFESTKAGKRQEQQVQVVWSYLSSPIMNDFITELRRLTNPEHIVKDFIDYAMGMMDNPSRESDRIISAFNELNQLLLNMKSNRLGPIPKAFALKHASQLYSICGRDGSKLSQMTTKEFRKFVKYYQSDIQNQKLPGSPELLKSYSPWLANFHHTNFAEDIEVPGQYTGKHKPDPTQHAKISNFDDRVLVMSSLRKPKRIRIYGTDENEYLFLVKGGEDLRLDQRIQQLFSVMNGILHKNEFCSRQGIHLTTYNVIPMTSSIGVIEWLEHTKPIRACLEETPVRKNQMVRLQEAYRSWVANFKGETMGYRNLMQAPRETVVKQYTLFTSTMPSSVLRDSTYTLAASPEAFLTIRQDFAYSLAAICICGYILGIGDRHLENFLIDRKSGRLISIDFGHAFGSSTELLPVPEIVPFRLTRQFSGFLEPVGIAGILRVPMINVLEALRNDQNLILNVMDIFVKEPLMDWKKIAIKRGKEQKRAAGSSGTTTTTTTPETDIEESSNFDQIAWYPQQKLEIASRKLKGENPGHIVAKELVIGHASKPYITSMKSVAIGDKQHNFRANIPNICPTVSDQVNCLLDLATDGNALGRMWVGWMSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PH33</accession>
    <name>A0A8H7PH33_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha-L-rhamnosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_005281</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PH33"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF5">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034840810" description="Alpha-L-rhamnosidase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="3">
        <location>
            <begin position="256"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="4">
        <location>
            <begin position="582"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2173861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="683" mass="74309" checksum="48F497F62CB2B5BC" modified="2022-01-19" version="1">MRTVPLILACAVVPALAIPEANWRQYVRAPSSTTIYPKKVLSTHGNVTNAQGLIQNHGIATLSRPSTNDTVPYIELDFGINIVGFPKISFAGASDNHPGVRVSFSESTEYLSNSSDFTRSDNGQTITPGSDQHAVPSGASDWVDTYGCQHNGTQVCSDGLHGFRYMRIALDALDKDAPYTSPNSTVDIKSVSLNFTAFLGTPDTYTGWFQCSDEKLNQYWFDAAYTNEMVTDHFRATDVDPRDAATPTLEGKLVLFDGAKRDRDPYIGDIAVSGRTAYLTHNISEAAMNVLADMADHQRSDGWIPPASINNYTLPLFDYALYWVTTSWDYVLYNGDMDYAKTYYTHLTNVLDKFYASVTDAKSLLNKGMKGTDGYGDYAFLPRTGEVTYYNALYVEALKNAATWATSLKDTTSADRWTKRASAVSTAINAHLWDDSVGAYLDTSNATAGVRHAQDGNSIAVIAGVANASRANSSLDYISKNMQQPYGNAFYDSALPGVDNTTERVYAFISYFELQARFLANQANSALEEIDRLYGWMSSQDPGVTYWEGIGPGGSKYEQSYTSLAHGWSTGVLPILSNFVLGIMPTGPGFSTWSVKPYPGNLDWASGQVATPHGPISASWTRSSKSFELDITAPAGTKGLIAVPTGSHILLNGRPLASGSYQVQDGYAQLNVTSGGSYKIQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHA4</accession>
    <name>A0A8H7PHA4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_005017</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Interacts with G-actin; ADP-actin form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHA4"/>
    <dbReference type="OrthoDB" id="10006997at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11284">
        <property type="entry name" value="ADF_Twf-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11285">
        <property type="entry name" value="ADF_Twf-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000007">
        <property type="entry name" value="Twinfilin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF1">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ADF-H" evidence="9">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="9">
        <location>
            <begin position="155"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="289"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2173599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="328" mass="36287" checksum="87353DBE1E61F9EF" modified="2022-01-19" version="1" fragment="single">SDELAKAYADAVASGETRVLRISIEKDFEQVQKYLDESQPSFILVRLDTKTSAGEYEWLFIAFVPDNAKVRDKMLYASSRASLTKELGDYRFVDSMWGTDPEEFTLKGYKKHKSHQSAEAPLTQRERELAEIKLAESKQASSHTGTTVRNTYAGGVSMPLSSEAETALKELSQSDRPHNYVSLRLDSHESIELDKTETITADELAKTVPADSPRFTFYAYAGHGSDEAAFVFIYTCPSSSKLREKMLYSSSRNGVVATAEKEADIKVAKKLETSDVGDLTEAYLKEELGSQQSVPSNGSIVGERIQMLGQKPGGFKRPTAPGRRRPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHJ2</accession>
    <name>A0A8H7PHJ2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ER membrane protein complex subunit 1</fullName>
            <ecNumber evidence="6">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">INT43_004122</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="29">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EMC1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="6"/>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28092at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13279">
        <property type="entry name" value="PH_Cla4_Ste20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000768">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000705">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058545">
        <property type="entry name" value="Beta-prop_EMC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25293">
        <property type="entry name" value="Beta-prop_EMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18 25" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="1027"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="1066"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="26">
        <location>
            <begin position="1096"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="28">
        <location>
            <begin position="1196"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="27">
        <location>
            <begin position="1509"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1259"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1342"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1302"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1427"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="1538"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KAG2174102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1765" mass="198024" checksum="3959FB483527C68F" modified="2022-01-19" version="1">MVFAKIRWRLVYDRRSNPRSSGISTEATFCLLSKRDGFVSFVTIKRHSRFRSPTWLFDDLLKSSQILSNVPDYFEQIIMHLRTDRISVWTVISVLLVICAQVVHALHEDQAGVLDWHHAWIGKALAAKEHNGIIYTATGRNVLAALNASTGEIEWRQLLSNPVRKFQLHNEGLVTVNDEETPHVQVWEPSSGKLIWEDSKVDDLSKDSKVVDALILSSGDVAILTSSGSVVIRTIAGGQHWRWIPELGSSTTPIMLAEVDGHLYAVNGHKGVLSNSLHIHQLDAQHGVVQGEHKVSASLKDLRSIVIVNNHVVWIEKHHLKINELGSAEVSSTSIESSKIFASQSILPDSYSVEVLDPKSNEILVTAQTVKEDINYFISAIVKIEDKKADFILELDMASQPTVASSLDDTVVVVQHQSEDELAIISKNSGAASTEVISHSIAHTGQVEYVSVISLQPLRTLVVTADASMRVYEGANLKWSREESLAYVADSEFIDLPEQKLWSQMADETSEDSSQLSPLERYVHRLQSDLKKIPALPSWFMSRFSGVIEALQRKRESSPLHLAQQSLTDPTNSTIIYRDNFGLRKLIVSATSTGKIVAQDTQNQGSIVWAKYYPGVHFKQVISVRSATVKMPPLIVVIGENVESGTMLIYRLNALHGTEYVTEDAKIAEYFDPVLETPTIATKIFRLPIEEPDERTHVLALYDAASTRVFIYPDTEGSRNAFQKFLPSFYFSLVNNDSTAIKGYQVVEGYRGSLTASPVWSYAIPKGSTLVAVGSRSPFENVASLGRVLGNRNVLYKYLNPNLFAVAHANPETQTMTMTLLDGVKGSVLYQVVHEDVDTVHHDVHIGTSENWIVYHYWTDGAIRGSSKGYQVSVLELFEGAEENERIDSNQQPHVRSATFVFPYGVRTLGITDTRNGVSTREVLFGLTNNHIYGVSRRMLDVRRPREKPGKEAQEEQLIPYGPIPDEPKMFASYSLEILGMNNIITAPALLESTSLVFAYGLDTFFTYRAPSRQFDVLSEDFNKSQLLLTIVALAVGIMMTGPMVRRDKKDTGVSQNGKTKTSLEAPILNFFLLSCSVASFLFLFHIYTLLRYMAEVRKDGYVSVKEDGIRAWIWSKRYAILREQTLTFHRNEQTGQCVALIFLEEILNVHRVDLKPYCFEITTRDRVYNIACKNDEELYSWMEEIYSVRNSAVGTSSPTNFVHRVHVGFDPDTGKFTGLPDQWNTLLKHSKITAEDAAKNPQAVLDVLKFITEQDNDESKYFEEEEELSPKEAQQPQAWNPPLQDRKPKPSQSSPAPRLGKTPPTKAAAAKKNAYADGQENIRTDKATNQAWLQVRVKPSLATAPTPPLPLSPRGQHTDSLANTALNPKRARDLDVTLPTERGSPARYRSPRTPPTPQPSISLGLPQRKGPTTPKSFNTGELPSARYRERRRERERDYDQRVPKGSRPFEKEIRTNVKLVDDAKVPLKDNSSTAMFRGHERRISKMSEPEIMETLRSIVSKEDPTQIYKRNKRVGQGASGSVYLATHLVTNERIAIKQMDIASQARKDLIVNEIIIMKEAHHPNIVNFLDSFLVKGDLWVVMEYMEGGPLTDIISKHKLDEAQMAFVCLETAKGLQHLHSRKIIHRDIKSDNVLLSSFGRIKISDFGYCAKLTTQKSKRVTMVGTPYWMAPEVVTGRSYGTKVDIWSLGIMAIEMIEGDPPYMEEEQLKALYLIRTNGTPQLKNPEVLSRDLKTFLAVCLCVDIRSRASADELLQVSTFIHTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PI19</accession>
    <name>A0A8H7PI19_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_004201</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PI19"/>
    <dbReference type="OrthoDB" id="409947at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001409">
        <property type="term" value="F:guanine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000010">
        <property type="entry name" value="Probable YHM1 (Mitochondrial carrier)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053042">
        <property type="entry name" value="Mito_GTP/GDP_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974">
        <property type="entry name" value="MITOCHONDRIAL GTP/GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974:SF1">
        <property type="entry name" value="MITOCHONDRIAL GTP_GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="222"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2174180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="36116" checksum="4C198E80CB0CCA70" modified="2022-01-19" version="1">MSPPPSGKKHSESGLARFFGSATSGVLELFIFHPVDTVAKRLMSNQARLFVPGQNFSVGFSALEKVVFKDAADASAFKKYRSLFPGLGFAAGYKVAQRVYKFGGQPFVNDFLNNHYKSYFSSAFGEKTGKTMMHATAGSLVGIGEIALLPLDVLKIKRQTNPEAFKGRGFLKIVSDEGMGLYRGAGWTAARNAPGSFALFGGSAVVKEHIFHLTDYNKATFFQNFCASIGGAVASITVAAPLDVVKTRIQNRNFENPESGVNIIKDLLKKEGIAGFFKGLTPKILVRVARVVERITRGQVGPKLIFSFTVAQQLIPIFHKSFEANGITKSVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PI25</accession>
    <name>A0A8H7PI25_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_004430</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PI25"/>
    <dbReference type="OrthoDB" id="250329at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF3">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="98"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="204"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2174407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="33693" checksum="A6133C71E174413F" modified="2022-01-19" version="1">MTSYGYHVIASSAAAVVARVCTHPLDTLKTRLQVANEPIHFRTLPETYAKFIRTNSIASLYRGLPVSLVFSVPALSIYLSCYDITSGYLDKSTSLSRNHSTNHLLSGFVAEIFASLAFTPMEVMKNQLQTTKQSESTLSLASRIWRVEGLPGFFRGYTMSLAVFVPYTMTYFAVYEKLKSYMAQHYLSSPLNTPVKTDSMVSQLPFAAYMASSTIACAIGITISTPLDIVKTRWQISFSEQGTAYKGGPVYIIKQMWQQGGYRAFSRGMLTRICWGIPSTAISMTIYESIKDWYAMEHQNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PI59</accession>
    <name>A0A8H7PI59_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PI59"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2174175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="83" mass="9387" checksum="7DF9457E414D16CB" modified="2022-01-19" version="1">MTLMPYLRLRDGSKSPNERVSTLVVVISSRLWALVKRKRGLVLKTTKYDVRDPLDSVDFAPTHSPCLTIHLIKDRTAARIAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIX9</accession>
    <name>A0A8H7PIX9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_005875</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIX9"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16702">
        <property type="entry name" value="RING_CH-C4HC3_MARCH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="14">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2174813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="142" mass="17001" checksum="68602C966331FFC0" modified="2022-01-19" version="1" fragment="single">MLEICRVCRSEATEDQPLFYPCKCSGSIRYVHQECPLYTILTNFHNRYCELCHHPFTFTPIYREDMPERIPIRLFVTQFILRTLYVLLTIMRTIFVAIIWLVVVPYTALWIWRFYFWSGENIVINHRANMPTAENSTMQNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJF5</accession>
    <name>A0A8H7PJF5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJF5"/>
    <dbReference type="OrthoDB" id="428346at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2174870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="569" mass="64616" checksum="5C9761BD7312B8D3" modified="2022-01-19" version="1">MQPSYRKLDTTDQSIKYQLAKTLAVSSLASTVLLSFAALFYTTSRSHHASEALSHYKAFQCSLPPKLMLPMSEDETYTPPDPDPSLRKILTFVRPEDHDIYCEQFKQLGDAETATNLYDHHIKKECGNWQAKYTRLQNRRAQQLEQLKNGDLDERNYEDRPRFIAYICANLGQYHRSACGGLADRMMGMVSTFFTALISDRAYYAYWEPHNPFELETAFEAPNINWTYDIDTMRGIYDNSSVMTSHRILDTMNLKYPMLNSLVFPDGPDTNLTDLWPESVGVDLIAPASGDKAISTLIESKSNRGFILNTFRQSSVYPKYLYSMGLNEENIFGCITDYLFRPTIGSRRFIDAYRYLLRLDSVLSIGIQIRTGDSNIVDPETSIDTTSLSTYDYFFKCARQVGESRRQAHHTKVVYFLVTDSAALRDQAVSLNDNPVLSRQYLGDKNSKVLVTGLPIEHIERGQVSHAYTRHQNLTEEEKLSIEHQISHNEQIAGVNSAIIENYILSSTTYRVITKMGFGKMAAFNSRVNGTTYALPVLDKYNLGDVVPDCTDPDAIESFDSLSLMWSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJZ0</accession>
    <name>A0A8H7PJZ0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nicotianamine synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_001069</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nicotianamine synthase (NAS)-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJZ0"/>
    <dbReference type="OrthoDB" id="1858069at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030410">
        <property type="term" value="F:nicotianamine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030418">
        <property type="term" value="P:nicotianamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004298">
        <property type="entry name" value="Nicotian_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32266">
        <property type="entry name" value="NICOTIANAMINE SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32266:SF12">
        <property type="entry name" value="NICOTIANAMINE SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03059">
        <property type="entry name" value="NAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51142">
        <property type="entry name" value="NAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2175422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="35233" checksum="862B243CF63F36A4" modified="2022-01-19" version="1">MVHQQLPPMDTHLSGTHSVLCQHVIRPHSHHHIKSRLSASDDLVQEIESIYTGLSSLPSLEPGMTTNKLFSKLVSLCIQQYDKETITNVLEDPRIARLIKYLRDMCSVGEYLLEYQWSEKIVSDCKLLDISRDDPLRSFVYYENYIELTKLEIHTMLGCGVVPRTVVFIGSGPLPLSSILLTEMCSDVAKVHNLDIDVSAISVASELVSAIGKNNVIEHHQCDGLDYKGFTQADVIFLAALVGCNHEQKLLFLQRIHDQCEPGTAVIVRSAHSLRALLYPVVEPHDLVQCGFDVEVVLHPHNQVVNSVILARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJZ5</accession>
    <name>A0A8H7PJZ5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_001176</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJZ5"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="8">
        <location>
            <begin position="17"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="211"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2175529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="509" mass="56556" checksum="12C4D58BCAD61847" modified="2022-01-19" version="1">MKTESQAEKRKSISELHRSRYKRNSISKNADESRRRRLAIDQALRRKHREQLITAKRFRHLTQQEEYESAGEEEGDHHISYELTAGDISKIEEELKSNNHEVRLDAAKFLSRALFDPSKALRDFVVDGDCVNILTQLLTSGDAEEQLQAVVCITNISAGSYELCIKATPTIPYLISYLNESNIALQDQSGWALGNMAVEGDEIRNMLRRNGVVSPLIKLLDATDSHLVQTACFALSNLARGPDAKLEEFFEAGIVPKLTSHLINNTPDTVTEICWVLSYLTAGTDQFIGKVVEQGVVPLLVQNLESLQAQGPLALPLIRTFGNIASGPDEYTDVLISQDRFLPGLVALCNSECRPVKKESLWVLSNITASRRPEVLEKVIQAGAIPVLTEIASHTNFDIRKEAAFSLTNIACHGDKYIQALPNNVLLPGYLEFVRSEDPELIKLGLTYLQLLLTHVPQGKALMQAIPDSIYSLESVTLSTHSDLCRTASVLMDTYFGENNEGVEQDILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PK33</accession>
    <name>A0A8H7PK33_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Cellulase</fullName>
            <ecNumber evidence="3 10">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_001023</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 45 (cellulase K) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3 10"/>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PK33"/>
    <dbReference type="OrthoDB" id="10035502at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052288">
        <property type="entry name" value="GH45_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000334">
        <property type="entry name" value="Glyco_hydro_45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39730">
        <property type="entry name" value="ENDOGLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39730:SF1">
        <property type="entry name" value="ENDOGLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02015">
        <property type="entry name" value="Glyco_hydro_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01140">
        <property type="entry name" value="GLYCOSYL_HYDROL_F45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034534689" description="Cellulase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="13">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2175376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="319" mass="31984" checksum="964FE3FDC6222B66" modified="2022-01-19" version="1">MKATLILSAISLFTAGAAAASCSALYGQCGGIGYTGPTCCPSGSTCVVQAGNAYYSQCLPSSNSGTASKAASTSSTSSKTTTTKSTAALASSTKTSTSSSSASPTLVPVSGGSSGTGTTTRYWDCCKPSCAWTGKGSVTAPVDSCAANGVSVLSPSTTSGCDGGTAYMCNNQQPWAINDNLAYGFAAATIAGLTEQDWCCTCYALKFTSGSVAGKTLVVQITNTGGDLGSNQFDLQLPGGGVGLFNGCSTQWGAPSTGWGAQYGGISSLSDCSSLPSQLQAGCQFRFGWFENADNPSVSFQQVQCPTQLTSITGCARTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PK73</accession>
    <name>A0A8H7PK73_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_001194</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PK73"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="74"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="261"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2175547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="56289" checksum="983C5E3F196D71A6" modified="2022-01-19" version="1">MESSTTLVSANEESTSSHNQLSAASHRLSQTLNGLAHVGNRNRSSSVNASAAPNTVAPGTQASADSTAPTSLVIEFDGGSHVIVRPNRTIRGTVILNATERIYATRIRIKFRAEEIATVKCMEGSGDGRGERIHQLTTTFFETDFKLWGNDISAFSQTTWREIEVGQHSYPFALKFPNVNYPPSLEDPKGFCVRYGKVFFVLMCHADFVWSAQIDGPGLQSGLRSKEYLTPLRPIIVAPPSQEWVYKATLFKERKSTAIAEVQAKLPKQTFCPDEKFNMQLNIGVLASDYKVSSVTYKLRKHHEGKMLVQKGMAFRQYVRQVVTGNVPITSEGNQYSSNLMFDIPTRLVSPSFASRHTRVHYDLQFSVMYETGQFFKTNQSSEFTIPIAIANLPYDQLLRIPDLTAIKDYRNSKECPTFFDANLDEPPMNTGLPSELIGPLTAALASPPAQSPPSYFSLPSLPPQFEIQKERQERTVYTTRVLKGDHSVELGEPVVLSGVMDEDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PN78</accession>
    <name>A0A8H7PN78_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Urease</fullName>
            <ecNumber evidence="2 8">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Urea amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_007986</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>urea + 2 H2O + H(+) = hydrogencarbonate + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="10">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="2 8"/>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PN78"/>
    <dbReference type="OrthoDB" id="1708534at2759"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.280.10:FF:000001">
        <property type="entry name" value="Urease subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="entry name" value="Urease, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="entry name" value="Urease, gamma-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01954">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008221">
        <property type="entry name" value="Urease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050112">
        <property type="entry name" value="Urease_alpha_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029754">
        <property type="entry name" value="Urease_Ni-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009671">
        <property type="entry name" value="PRK13192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009682">
        <property type="entry name" value="PRK13203.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009686">
        <property type="entry name" value="PRK13207.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43440">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43440:SF1">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001222">
        <property type="entry name" value="Urease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="Urease, beta-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="Urease, gamma-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01120">
        <property type="entry name" value="UREASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0533">Nickel</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="13">
        <location>
            <begin position="397"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11 12">
        <location>
            <position position="588"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="10">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="10">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="514"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="540"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="628"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="9">
        <location>
            <position position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2177329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="836" mass="90031" checksum="0EF84B17C8BFEF19" modified="2022-01-19" version="1">MRLVPRELDKLVLHQVGALAQKRLARGVKLNHTEATALIASQILELMRDGTHSIAQLMDLGKQMLGRRHVLPEVMETLLEVQVEGTCPDGTYLCTVHEPISSDDGNLDIALYGSFLPIPDNSKFELPATIPKPEEAPGAIIVKPGKLQLNAGRDRVALTVTNTGDRPIQIGSHYHFIETNPALLFDRAKSYGKRLDIVAGSAVRFEPGDTKTVTLVDIAGNKVITGGNQLASGPVDMSKLSAVLEKLQTHGFSHQELLTPLALPEPCTIDRRFYADHFGPTTGDLVRLGDTDLWARVEKDYTVYGDECKFGGGKVLREGMGQKTGVLDEDALDLVITNALIIDYTGIYKADIGIKKGIITGIGKAGNPDVMEGVTDNMIIGATTEVLAGEGQIFTAGAIDTHIHYICPQLCFEALSSGITTLIGGGTGPNTGTKATTCTPGAYHVEYMLQATDDMPLNFGFTGKGNVSAAEELRQQIEFGCIGLKLHEDWGTTPAAIDTCLTVCDEMDVQATIHTDTLNESGFVEATIGAFKGRTIHTYHSEGAGGGHSPDLIRVCGEENVLPSSTNPTRPFTTNTLDEHIDMLMVCHHLSKTIPEDIAFAESRIRAETIAAEDIMLDLGAISMISSDSQAMGRVGEVVLRTWKTAHKMRVQRGKLAEDKDEEGDNFRIKRYVAKYTINPAISHGVSHLVGSIEVGKVADLVAFDPAFFGTKPSLVLKGGLIAWSDMGDANGSIPTTQPVIGRPMYGANPSALGKSCIVFVSQASIDKGNIADLNLRKRVAAVKNCRGISKKDMKLNDALPAITVDPETYDVYCDGILATCEPVKKLPLTQSVYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNA2</accession>
    <name>A0A8H7PNA2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNA2"/>
    <dbReference type="OrthoDB" id="5819478at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36851:SF1">
        <property type="entry name" value="GLYCO_TRANS_2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36851">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="2">
        <location>
            <begin position="231"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2176890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="576" mass="65391" checksum="ABDA0F4982B3CA87" modified="2022-01-19" version="1">MSKVVLPSLCELVAPSVAITALLLLPLGPILIPRFYLIFLLFYFTFFLYTQINHVFKFYLTAKHMIYNIRRWNRHEKVNTPDAFSTSSGTNSPQPTRERYVSTLNEENLDDVEASLKFYEDSRYVHTFIVPNYCEPEALLRDTIKRLANHRNARTSYVIILAMEGSEIGHEEKGANLLNYFKNSFLHFLITVHPPDLPGESRGKGANVSYAARNGCNELLLRGVERRHIILTVTDSDSAIPELYVKEVDRALALADDPYMLLLAPPIFFSRNSFEVPAAVRVTDITWSAMVMSNLSNSRGLAFPCSTYSLSMVLAERVGYWDTDADSVGEDLHMWLKCFFKTDGAARSAPIYVPINLTNVQADGYMSNMYARYVQATRHYNGVADVAYTLKSSFGGTRSSSLMSLLPTAGTGKNAMYISPYYWLDKLIVCVHVLEAHMIPATSGWLMFAAVPVMQLIMFPPFSFLALVEPATNPILISDFYSTLWNIVKIITVLLPFPLFATLGIYEYLHRIVDRELFRKAPTECRTWRNVVDYASLPISAWMFMTLPSTLACLKRLVKTDHEYIVAKKVFNEEQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNK8</accession>
    <name>A0A8H7PNK8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Autophagy-related protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008004</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize preautophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Preautophagosomal structure membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATG17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNK8"/>
    <dbReference type="OrthoDB" id="1937984at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007240">
        <property type="entry name" value="Atg17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="7">
        <location>
            <begin position="16"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2177347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="447" mass="51496" checksum="A3A12F94FF68869C" modified="2022-01-19" version="1">MEQDLINILLFAKKALHSGQAIGGQADQSRKETESLAEMLETQWPKLLFLNEHITTQLNTLIKVHDFIYLTAGDLQGFIKSKEAALGNLSMAVQQTFDSLKKHYIDPEILEVNKKYTKEHNIDLNTSRNSYMERKTLFDYIDDQAVLDLQQQTDDEISAVEVGMAKSLSNTTQSLQNTQKAILAKYFTQNASSFVIDKKEGQEHALSQMADILNSLLQHYAQVGEAMKVLQANPNELLDIKVLQDDHDHLPDIIDSLQAYLQEVEDIRNDLRYRSEEYGDASDEMAKLFLELEQLGEPKGTLDNIFEKLIMIERKLQEHKDTLNNYFENLWVLVDWYSQYAVSYHYMTIEIARRQKAQQKQTKLLEDCLKKFEDLYIEELENRKEWATKHAAYLPTDLCPFMNEPPPRITFNTSPGGHELPDISPQVVEEAIQRTNSYALKGSQEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNL5</accession>
    <name>A0A8H7PNL5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007639</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNL5"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF37">
        <property type="entry name" value="ABC1 FAMILY PROTEIN C10F6.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034705837" description="ABC1 atypical kinase-like domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="107"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2176985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="539" mass="61546" checksum="A2F44D1A427670DF" modified="2022-01-19" version="1">MARQRLFKSILAVTTTGLGVYAYDSNTEAQLVTRNVRTFYNGIGLAVDYKLNFKPGDLSSMEAVHERVANRIYDVCERNGGLYIKIGQVIGTQAAVLPAQYQKRARKLFDAAPAVPYSVVERVFQEDFGVSPHEIFKEFDPKPVASASIAQVHKAKLHDGTVVAVKVQKPAIRKQMDSDLLAFRMLLHLYERLFDLPMVFVSDYVEKHIRMEADFEREAHNSMIAWKNLQKEKTLNGLVYIPKVFSEIGSKRVMVAEWVDGVQLTALDKLKAMGASPAQAMQVTVEAFASQIFKSGFLHGDPHPGNVLVRKHPHKKNQFQVVLIDHGLYIEESEKFREEYCRLWEAMFLLDTKTLNEICQKWGINDSNMFASVTLQKPYMPSKAPHLAQGNVSFHDAYEMQMSMKTRIRNFLVNQALFPRELIFVSRNMNIVRANNKAMGSPVNRINIMARWAVYGLESKNKEKRGIRDYLKHSWRLVLFETTLFAMTVSFYIVKLTEKANQIIWGKASQGFEAVLDARMKEQLQQQFGIVLDESVFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPC3</accession>
    <name>A0A8H7PPC3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPC3"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF33">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25764">
        <property type="entry name" value="KIF21A_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="723" mass="82100" checksum="F3883442C141A62D" modified="2022-01-19" version="1">MTPETSISETSKSSDFRESELRERPPTPIDWEGNILEGLDVLTVPVWTDEVKSKFSNGQNDGQNKSNVSNISLPSASEEVALNNARHIKADENKPDDGLSDMQQKKMLHQIQSDLLVKEELVGHLQRSQAEYMAMKENYEDQLLALRDQMSELQQEARMSCRTPDNRRASLNQPHVTTFASTTTSHELEIKKLAGEIQELQKKYNHSLSATQTANAKNEKQFHAYKLSIEYMKLEKKRLVSSLKEQCEKTKVLEEEHRTQLSINRLERDELAESVIKLNKELQSTKALLKKKSEEAATAASQMKQMIPILDRAFKNGLVYDELPEGIKSKLSQSPSPLVTTQKSKFDGSSKSKALRKKQQLERMIQQYVQADQRAQDYKQMLIKRNMICMEMTELASERDELNGIDQISVKSRINALNYKIEKLTKVLDHIHEQVEIHQNQFSNSPKFELDNPLSRESNITNSSQIENEGLLDRKGAYDRAMNMVRSVNAEEGKLLAETLLTEVLVLKSRESSRDVGTVQTDYTMQNLRKVLASMKDNHVVDGPESLIINDKHLQIEPDDDQYNSVKATIEEPHNQVSGSISSEIKQLDLKSRDQHQAGEVYDYVCSRPHILASVSDEFSMGGPPDGSTLPPSIISKRCSFRLTENHGPAEKHTKSLGLSNSLTSRKISTLPLNHRRWTLQASYCTSEDLTANPTNTIFDRLANKHTLASHAKINPRLYYNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPD5</accession>
    <name>A0A8H7PPD5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPD5"/>
    <dbReference type="OrthoDB" id="4088568at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="206"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="874" mass="99806" checksum="A21820EC05649D9C" modified="2022-01-19" version="1">MQSHNRSLSAAMISHDLQEWLTRTSAEQPAPLPTCCCEQLTCRSSELFKDTIKRLEGESRLAAEIGQSLLLKYERCVHEDDQRRREYEQKLQRSEEKLKKLRKINDDLEKHNEELTLQNNKTTWEYEKAQQTIQSMSAYLEVTNHTVEKLTADNEAKNAEIEKTRILRMLTRQADLRDEMNESKIGDLKQELALARKNELFLESKHRKLASRYETLQTSMDALKQENAALAEAAENGSNAGWIRKVNDKLKNIEMKNGGFDVRPQQYQHLITLIKELGFSNNKLKNELAEYKDMLSDSKAEVTLLNAKLEQLEGSDDSELDSTVAHKQSNMNPSRNRVIEEEPESYHVPSLPTSDSQQAYSLPHDNIASENMRSSLKMRRSATAMRTSDKQSVNRLATRTLTTPLYADPTNNLSSSSLSSPSDNHTVVHHHYHYHVHKSKSAYQDLGVRRLRKETSASDGYMSEEQNQKSLVSSKSIYTTDISKPVVNPISSTRSKSLLSSSLHDLSKKKPVHSVASSESASQSTLWNSKQTEFNNDGMLKGVQAIEYPEPSETQGVSLCKDAPYHSLHHLGTHYYERLKATDIRALNRQLRRTFDILELSSMSNSIIDNVLADIRVLKTRFLWVEQSITTYRNLVDADVSARPWESDVSMDDFFPLVELTEILLSEIGQMRMTLNDLQVEYVSKVEQIGHRSEQDVIDKRRIQKNKPTGPETTFSWFTNILSRYNIKDNESPPVQKRHKRTVSHESITSQLMERMEETEEDIKPSDPMPAQNNTRKNDYVEATSYLSNSVFGSTAFDNNKLLKSSATLIPRASKSTGTLRKVQKDTPKSSLRQYIANAVSENLSDHFSDDSRPTSPDIDWKIANGIGTRRYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPF1</accession>
    <name>A0A8H7PPF1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPF1"/>
    <dbReference type="OrthoDB" id="2289866at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="278" mass="31688" checksum="1722FD5D9C437A6F" modified="2022-01-19" version="1">MNNWVHPDPIMNERMVHARHGLLVKWCGCMSLRGGSAFAAVVWLGLNIYLTVLSFEARSPIYSDLNFNALMVTGVICLLFCLGSLFTLFALFQNRPPTVRMAHQLTWLCVFAFLTDAFINIIVFGILHGDFQNWCMDRSKGYVDEQITAILGNGTQITMSFTPSQDGTDIYNCQKMWEDELKLGIVVWIVFALVYIYWATCLWSYSQKKKLLEIYTIQMNNNPNVMMNLPPGASARDVEYEDDGGKSMAQRSREIYSGLRAMLSRNRAQPQMNPVKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQ18</accession>
    <name>A0A8H7PQ18_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_003350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1893551at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="181"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="297"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="356"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="672"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="843"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1138"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1272"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1162"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1173"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1211"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1232"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1287"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1302"/>
            <end position="1317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2178097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1420" mass="158508" checksum="7ADF3312FDE181EE" modified="2022-01-19" version="1">MTSIFKAVYENNVESIKQFIADANRTTPSSKDPQTASQPTRRKSNVPIVNINKRSILGRTALHLAASWNRMDILQLLVDCPHTNVNIRDRENGWTALHRALYAGHIESALILSSQEDIDIFIKDFEGNTALDLYNSTIEGTSPSPRTIENIKRDNHDGDAFHGLKSSFWSLEESHSSTGATDIFTWGYNTNFVLGHRDSENRTRPDRVHLNLVTQQIPQVLRRPAYVIMSMIMSKFHSAIITSEPENNLQLCGFGGARLGFGNEDTQFLFKPVNGIHDQVVVAALGRDHTVVVTRGGDVYSFGINNYGQLGYDTEQKQGQRIPQYAPRKIAAPSIKKEHIIGAAASSVHSAVFTETDLYTFGLNQGQLGYYPANGDFVQVVPRKVSFLPSGARIIQVACIDNATVVLTASHDVFVLFNNGHQKVVFPMQRFPSDFVAYTAAPNFIVKIIAGGDDYVGAISNMGDLFIWTITTRKGSTSGQKTKTDAGFVGVENQRSRAAIVPRRIWALRKSHLTLADACIGQEGSVIVCTTSGHVFVGSPRKVPKKNKNLVEKKLYKFNKIPLLQRCIMVAASPTGAFAALRAEKPLKSVDVPPSTLAMDLLTSLPHIQNAYRLQKLQAEEDKLLRHLSEERLKIPFFIETEAIDAVPEISENAPVLDWDKYITSDIADPTIDAYIKVGQKGYQCHQVILAARSAVFEKAFSNLHIGGDSNVVLNHNSGRTAKFVKSNNGKVRSTVEILIEGIHMESVWFFLDFIYSDQYEHPMNAFYASSKHHTGDLAVRTKLQTNISADVLQKELIYLADVFKLPTLQDSVSSSFNARPRPTLTTDIGMAQDREKSRQYLKDVLLELEDAVLDCHEVILRQRSTFFDTVFDPNRTWLSNRRQQSSKSATTIDLNHFDHKTMDIVIQYLYNDNRDSLFNELVDSSTNSIFNVIIGVLAVADELMIDTLKVVCQIALLKLVTSKNVLVALEIADLHRAEHVKAACLDFIAHNLDYFLEAGVLEEFSPSLVEDIQSEVQKLQSCKAFLSRASFSANGQRLGLDNEPELNIAIQMDFTEQSMWATPDEIYYTVRPKKPIESFKHSTVISNDDDDLIFQQDEDILSEQTKYPQRSYSSRTSLKDTLYETPTIEHDEAEFPALGNSCEGMGISKPTSIPTSKRGWSFQSQDNSPKQTIRELLDNHDPAPATKSSPTRPVIIPKKLSQRERRKLQQQEAANIAETVNTPKPVWGKPIQSTPAPIMSSSPGSAPVGTPPAIFNRKPSMAEILEDEKAQKLRGKQAGSLPESDYQEKKFFESREAAEQSLRSSSAMEPSSSTSSNATINPMRKASTTYKPTMISRRQKDITANAASEESSDGSAIRSFADIQNQQLKESMVRGKKFKKSLIRIQQEEQAIEALMEFYTQTIDIGTGEWFRIARAETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQ90</accession>
    <name>A0A8H7PQ90_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginyltransferase</fullName>
            <ecNumber evidence="2">2.3.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_003344</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the R-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQ90"/>
    <dbReference type="OrthoDB" id="74183at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017137">
        <property type="entry name" value="Arg-tRNA-P_Trfase_1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037207">
        <property type="entry name" value="ATE1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="7">
        <location>
            <begin position="21"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="8">
        <location>
            <begin position="176"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2178091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="396" mass="45879" checksum="04F80C0CB5CFD883" modified="2022-01-19" version="1" fragment="single">MSRNLADSDISIVSVVGDNVSKCGYCGGRDTSHTFGIWAHYLTCEDYQQLIDRGWRRSGQYVYKPNLKQSCCQQYTIRCPISLIEFIRLDANHFAISKSQRKLVHKFNRYVLESQEVEKVESNNNKKQKSKSSQKSVPDTLLHLMSKPEHGQNMKSDDTPEHKFEIEMEPSSFTKEKFDLYCKYQIEIHHDPPSKLKEKSFRQFLVDSPLKPREFDSEQDAPCAGYGSFHQTYRLDGKLIAVAVLDVLPNCLSSVYFMYDPEYAFLSLGKYSALREIALTQTMEQKASKSIHWYYMGYYIHTCQKMRYKGQYKPSYLLDVESYMWEPYEQCAPLLEESKYVAFKKAIQQRSKNKDNGKSLDNTRPVPDFSPEVLDPTLESLQSILSIFSGMLVPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQT4</accession>
    <name>A0A8H7PQT4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_003451</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the pacC/RIM101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQT4"/>
    <dbReference type="OrthoDB" id="6155966at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050806">
        <property type="entry name" value="pacC/RIM101"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257:SF1">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC_RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="12">
        <location>
            <begin position="111"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="12">
        <location>
            <begin position="272"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="466"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="790"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="857"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="918"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="969"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="793"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="867"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="918"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2178198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="990" mass="110130" checksum="E4789C1BF416A6CA" modified="2022-01-19" version="1">MQALQWSSHGLTYVNRFYLDHFSARTLHRAGEGTTTDNVDRWKSRYLDNDSSALFRAPSVLSTANKPAVKNVNYLKQLQRTNIVRPLGTQTKSFISLVPVPSSWVDTKGGDMCTKCDQEIADQGVALASGAPYHKECLQCQKCDKILDNPSFMSTNNKFYHNEVRFILISSNSTEMDRYKLTYLGHACFSCTACNHHLAPSSMYKEMAKFAYCKGCADTKFAGEDATLTTKVVPQPLSVIPMMVSKSEDKDVKPSTLFSSRSKPLPKFGITKLCPGCDKVVGIMEEKNGPMATKWHKQCLKCEGCSKALDSGAMMKDSGNLTSLICRACHENCALWALVCLGKELKRLLIIFFSTFYYFFSPLLQSLSSHYISIKDPISLQTYDDPEQLYVHLTNDHVGRKSTNNLCLSCNWDGCNVVTVKRDHITSHLRVHIPLKQQANHYANLSLIEYLAHNCEICAKSFKRPQDLKKHEKTHTQEHQATLRSRQTTNRAPRANHHPLTPPQNPYSSRSASVASDGSYSTSGPLSPPHSMTSDGGYSPISEAHSSFSRLSSFDVASEDTPYSNYPTKDFGGDDMMDDAQINVMGGGQFGENALDELFTDVLRNQKLSPEYDTDMVDRLNTLSTFVDNGSLNAQLESPEELDQMQRWLQNLSNNINISNGYGAPTSHMSSPMSSTASNLQYPTSFAMDEKPNYMSTQADLQAVYPQQIMDDGSFGYANTNALYPSDDMYVRSHVQAQPGMQYPMTDMQQPYEQPSPYEMGGNIGHRQHFIAAPQVATNYWGPTYQTTQNFTSAKDSSPKPSDSVDFSKKNVVPPSPSSISSSDKVVVDNLPRIKKEEMIDYENKKQMVSMLNVFTSPDSQPFTKEQAPKVEEKVEPECAKSEPAEPSEQKPPSKVNEIMNLLSSDISGLSIQESATKSPYANLSESLSTEQKQPTVSQTEKAPAISKDMRQKHYQLVQRLSEALDAMARDRTSAKTSIDKSPATVSGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PR93</accession>
    <name>A0A8H7PR93_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_001688</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PR93"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901991">
        <property type="term" value="P:negative regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000016">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="556"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="627"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2178842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="653" mass="74634" checksum="D61AC132594F6A9A" modified="2022-01-19" version="1">MKGLKGVLSRSKASSTSSSQPSTTNNDQKRQPTINAQPGHSSSTGQQRPTGESSTHATTPPIRVSTTPPPNPDSPIQSPKLKSSSLTKGIGDVPKNAPINRLKGTPKDTIPVSKSPRRQRSSRFHSHENINLEKYPNFNEVPAHQRHELLLRKLVQCQVIFDFNDPSSQLKGKEIKRQALQEMIDYVVTTKGVIVDAIYPEAIRMFSLNLFRTIPPPVNPVGDAFDPEEDEPVLEMAWPHLQLVYEFFLRFVESPDFNTSIAKRYIDQKFILQLLDLFDSEDPRERDFLKTTLHRIYGKFLNLRAFIRRSMNNIFFQFIYETERHNGIAELLEILGSIINGFALPLKGEHKTFLSKVLIPLHKVKSLSLYHPQLAYCVVQFLEKDQALTEEVINGLLRYWPKINSPKEVMFLHEIEEILDLVEPNEFQKVMKPLFQRLALCVSSQHFQVAERALAFWNNEYIVNLMGDNIEVIMPIMFPALYENSKTHWNRTIHSSVYNALKIFADISPRLYDACTLEYNEKQKINEKRNEGRTQLWKQLESNVQRKSATPDMAHISVTDNDSNMSGGEINQAVPLNGNLNDVDSTQYRQEGGDRIQPEMHPFSEDNSQLRRKSKIPMGANVLSQSENYHDPVENVTSTSDMMDVLTPEDQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRU7</accession>
    <name>A0A8H7PRU7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">4-coumarate--CoA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_001763</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRU7"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="29"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="448"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2178916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="59989" checksum="917077B65769201D" modified="2022-01-19" version="1">MVFKSEPLLLMPQTGLTSFIFSNPNNVADDKPIFIDAETDKHITYGQLRNLVFRLNHGLRRIGFKKGDALCIYSANKVDYPVIVHGTVAAGGVVSPANAAYTAEELAYQLQQARAKYIVTSEENLKIALDAAQQVGLPKKNMFLFGQKAIDGVLPYTQAILADEECPAEEFDFEEAKSTTAYLCFSSGTTGRSKGVMSSHTNISTNCLQIAQAMKKHLDYNTARFIGFLPFYHIYGLSAMIHLGAYWGIPVVVMPRFDLAKFCQAIEKYKVTIAHVVPPVLVLMAKDPIVSNYDLSTVTHYQCGAAPLSAELSMAVSKRLNSKCVQSYGMTESSPGSHIQPLDNETHGIVGRMLPGMTAKIVNEDGKGKFKPLFAAVGLGERGELWMAGPNIMQGYLNMPNETAATIDNEGYLHTGDVAIIDSNGMFSIVDRVKELIKYKGFQVAPAELESLLLQSDLVADCAVIGVYDDSQATELPRAYIKVSSGVPENEETAKALIKFVDQQVANHKKLRGGVKFIDVIPKSAAGKILRKELRAMAASEAKQSISAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRX8</accession>
    <name>A0A8H7PRX8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SLC41A/MgtE integral membrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_002022</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRX8"/>
    <dbReference type="OrthoDB" id="666972at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000001">
        <property type="entry name" value="Solute carrier family 41 member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF7">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="100"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="313"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2179172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="452" mass="49562" checksum="BDD8798D9E3702C2" modified="2022-01-19" version="1" fragment="single">DEGFASDQSQDDEPDDKELHVKFEPRNSQDSEASVHLGLLESQDGLSKEFNHEDTSNRIAWQALPSVLISIAGLIAAGELLDVYLHWDVFIRIPELFILVPVLLNLKGNLEMNLAARLSTSANLGDLDNRATCRKLVFGNLALLQVQSLIAGSIAGLFSFILGLLTRPSNDASTYYESMLVISSSMLAAALSSFILGIFMCLLIIYSRRFNIDPDNIACPMASSLGDIVTLVILATFARLLEQHMDSLLSTVLVIVMALLLPGVAALVWYNKSVKPLLFTGWTPIMSAMVISSLAGVVFERFVDSYKGLALLIPVLNGLTGNLGSIYASRISTALHADRQEGYKQVEKILLIMNIPVAIILVVIIWAFDLGEFQVNIWFVFAYVLVSMACAWLAVKLAKSMTLACWHWGKDPDNTVLPFLTAIVDVISTAMLVITFAFFSLSGFEGFKTVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PS18</accession>
    <name>A0A8H7PS18_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS1</name>
        <name evidence="8" type="ORF">INT43_002072</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PS18"/>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2179222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="292" mass="32815" checksum="93930AC1543D5C8C" modified="2022-01-19" version="1">MGYAYVSTESGKTVFSVATLTTPNSTFSIAQQSPITLQLITRLSFSVDPFTRKDWYDIKAPSMFDVRQVGKTLVNRTQGLKNANDYLKGRVVEVSLGDLTKDEDRAFRKIKLRVDEIQGKNCLTNFHGMDFTSDKLRSLVKKWQSLLEAFIDVKTTDGYLVRLFVIAFTARRRNQIKKTTYAQSSQIRQIRKKMFEIMTQESASCDLKELVSKLITSSSPIAQDIIGHRIEKACQGIFPLQNVYVRKVKILKAPKFDVQSLLALHGGDAAGDADVGTKIKSDFVEPAVQESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSD3</accession>
    <name>A0A8H7PSD3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_001736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSD3"/>
    <dbReference type="OrthoDB" id="2393060at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2178890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="155" mass="17565" checksum="22CC36E8A142617F" modified="2022-01-19" version="1">MVDRKKALKLKHLLLHKDPAMHQTLPEMKNPHPLVISPPILSPTRTSSLNYLLSPTTIYPSKSISTHMNSVSPRPVVRTREADNASAAANALNDTRSRRRYSFSGGKVKMYNSPHVPLHRDVDREKARKMRELEDRIVGRRQSTVKLTLTPRSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTG5</accession>
    <name>A0A8H7PTG5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTG5"/>
    <dbReference type="OrthoDB" id="361362at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="95" mass="11017" checksum="AD79437CC6ABD367" modified="2022-01-19" version="1">MTYFPYGSDSLGRREQKVDVVIQEMNIIICELVSLFLLALKSAHERENSKKAAKRTQQGTTKHLNLEPWTTHVVDYVLHVLGKEVRWIMNAVYDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTW7</accession>
    <name>A0A8H7PTW7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTW7"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2179758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="306" mass="33477" checksum="7328E3F4006AD7AA" modified="2022-01-19" version="1" fragment="single">GTNELAAFALASMLAGLTGWSIAVGIATAMDSSHDGEEESQDIDSYLSIQFQKTLLALAVLLVPVGVIWWNAAILLTMLGQDNEIVALCGMEGMDNQGLFWLFYFPEVGSNMRVHGIINLAAHSILMMVASSTFILPFGISVSAATRIDHWLEYDEPTYARRSLQAAFFLSTMFGVVITIFYRLVAQFIAAAFTSQPDTASILIDILPLVGICQLFEGISTVASGALRGLNRHLVGTYTTLLTYYCLIFPLAFLLSFAYDMSLSGLWYAMIVGFAVNSVGLLLYLKGSVDWNREVELANNRECDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PW12</accession>
    <name>A0A8H7PW12_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Heat shock protein 90</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008688</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PW12"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000005">
        <property type="entry name" value="Heat shock protein 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034202309" description="Heat shock protein 90" evidence="7">
        <location>
            <begin position="27"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="741"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="748"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="159"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="181"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2181106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="770" mass="86702" checksum="FCC74FD8C779F3AB" modified="2022-01-19" version="1">MPAPRIIRMAMLGFLASAMLATSTFAEPQQGEQIVLSSTEHHAPGAGAQGFSALDTEKIRETEEKYVFETEVSKIMKIIINSLYKNRDIFLRELISNASDALDKIRFMSLTDSASMSTNSNLNISITADPVARTLTITDSGVGMTRQQLKDNLGTIAKSGTSEFLSKMEESKKDDVSLIGQFGVGFYSVFLVADRVTVASKSNDDPAQHVWVSDAVNDFTIAEDPRGNTLGRGSQITLHLKEDAVEFLEPSNVESLISKYSEFINFPIFLWKGHNETIISEKSETLESNDDVEEEEIDSEKTEPEELTEEVWEWSQINTQKPIWTRSPKDITEEEYVEFYKTFTKSNDGDPIAWSHFKGEGDVDFRSIMYIPPRPDANFYQSLASATNNVKLFIKRVFITDDVAGDFFPRWLSFLKAIVDAEDLPLNVSRETLQQHKTLKMISKRLVKKALDMFAQLAKNDEKKYSEFISHYGVALKYGAIESQSHRKKVASLLRFRSSQNAQDAVVGLDHYIERMKPDQKHIFYASGMTIEEIEQSPFLERLVADGYEVLYFVDPIDEMLMQNMPGYDGKSFSNIAKGDIKIGDDSDEAKAEHKELEETFKPLQNWLKSTLSEYIDKVTISKRLATSPMAIVTPEFGLTGHMEKLLAAQGMNAAQKEDALYKFMASQKKTLEVNPKHPIIKALLDQVESGEPDEDITQLVTVLYETTSIRSGFQVKDLRGFTQRIEEVVGKGVGAEVAKAPTLKKEEEEEEEEEPIVPEDLFVGGHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWM2</accession>
    <name>A0A8H7PWM2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_008823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWM2"/>
    <dbReference type="OrthoDB" id="16729at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061640">
        <property type="term" value="P:cytoskeleton-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009991">
        <property type="entry name" value="DCTN3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07426">
        <property type="entry name" value="Dynactin_p22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2181240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="137" mass="15564" checksum="2D9394CEE5FE50B5" modified="2022-01-19" version="1">MDEHGFGDRIWRLERLLEDLPSKETVEGDEPLETMALYNRLYNLQDALDNCLADDTALRTFIERYGKYEKLLNPSSTSFAVEEELLDSTTKKELILAASSDLEAFATQIKQIQSLEHVVESSDISGEFSNRQSITCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXR7</accession>
    <name>A0A8H7PXR7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spliceosomal protein DIB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_006993</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DIM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXR7"/>
    <dbReference type="OrthoDB" id="147752at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR017199-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2182066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="142" mass="16680" checksum="78C7CE6EDDE81A41" modified="2022-01-19" version="1">MFYFLPHLSNGWQVDQAILTEEERVVILRFGHDWDPTCMKMDETLYGVAEKVTNFAVIYLVDITEVPDYNKMYELYDPCTVMFFYRNKQIMIDLGTGNNNKINWSIDDEQELIIIINAVYCGARKGRGLVVSDKDYSTKYEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZT4</accession>
    <name>A0A8H7PZT4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_006322</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cclA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZT4"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049455">
        <property type="entry name" value="ASH2-like_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053835">
        <property type="entry name" value="ASH2L-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21198">
        <property type="entry name" value="ASH2L-like_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21257">
        <property type="entry name" value="PHD_ash2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="10">
        <location>
            <begin position="266"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="202"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="500"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2183317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="611" mass="69650" checksum="C561F3401463E081" modified="2022-01-19" version="1">MVMQQPPTLTWNAQHTVNEEHSYCYCGRDRSLLEPNIQCRRCRNWFHVGCLQKPISHALPFMTNYTFQCAMCREEEFFERITASWKDICWTAIANLILQEVVKENGPDRSLYTSKNAHLMEVVWQPDRYYFNKKDHIIPFVDANWKSICTDRARTTTWWATLGSTLYTAKDMFVTRDESHRTAASDFCLVDANLWNVRPNVVQAGTPSTSSTPKPLPREKIQKAEVSVSTPVSSPSPAASPTPTVATFPQTSQADHPYNRYGFKYTPCKASPNFKLVNYRQEDANGCALSTTDRSPYASISRDGMVLTTDKGWRMCRSNVGVRHGTWYWEATILPSQGSSSDGPHVRLGWARREASLDAPVGFDAYSYGYRDVSGEKLFSSRREKYGEGFQVGDVIGLMIKLPKVKTSNFKSPNRRRIPIAYKDALWFEEKDYKQSKEYEALANAYQQNTPRNSGVLEGWNPRTLENSQIEVFKNGISQGVMFENLFDYEDFGRLAESIKGSRRSKKRKANTDTSSTSMMANGGEEDDAARRQQWTEEAPIKDDGTLGYYPAVSVYGGGVVSCNFGPHFQHPPGGSSDWRPMCERWDEYMAEETVWDLVDEIDRRSRRSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZU1</accession>
    <name>A0A8H7PZU1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_006171</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZU1"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22748">
        <property type="entry name" value="OTU_OTUD6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF10">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="3">
        <location>
            <begin position="234"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2183176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="399" mass="45296" checksum="10182F4659D3F516" modified="2022-01-19" version="1">MLFSVTVGVTCLDIRAKFIAIDRLHCVANVKVTIIRGMNNDEDLYKAVSDALKDNNVKENNGFTAEAHACPYETLEEILARHRREIRQLNADTTALKKTATKGEKKKKKDILTKVAIMEDELNKRHEEELRKHKLQPGDPDNVETAVDEEDDGISLDRLNELTIEEGPIAPTGTPSIGANGGRKKPNRQKLRKERKEAEIQKMKDEAEKEADGQVDRGKLESDAIKELLVPMRLRVSEVPADGHCLYNAVADQLAKRYKVQTDYKKLRKEAANYIRSHPDDFIPFLYKDDGGMYTEEDLKNYCDDLENTAVWGGQIEVSLDGNLLELNMQIVLSQRLQIMALSKVEKVPFYIIQMGSPVLKISEEDFPAKPPIKLAVKQSRYHKHLYSLGEHYNSLLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0B6</accession>
    <name>A0A8H7Q0B6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0B6"/>
    <dbReference type="OrthoDB" id="10355567at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2183190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="558" mass="64274" checksum="E20AAC9B3E7834F7" modified="2022-01-19" version="1">MQVNRSPYAINWYTYISDDVYVDDMEAEDYQAQLGWTAWRYALLVGTAPPQNIIDDPRYLPFVSQNPNALIDLHEFRPRENGGLVRFLDLIGTEGWPRFLDHYPAMVCERMTTWGPRLSIQDMERADVSLVRRLVHHHVSLAVMLGQRPTRLTADASSNQYMLNVCGKMTAKNLPNGKCVLMLWMIHPSIESLISWNKQTFQALLQMVPLVVNVIEKVLHQMGIKFQEGQEPGLKEDQAEKIIDWYHNSLLGQKISQLVDRLREEWNVSVNNAEQIEPLDDEPLFSIEDLQRPPVKIATNEISENSVAMGTIAKEILISGVHQTLFRTKKFDTRIRRRCKAKNPRFDFLSDEARQMSLPVNVSLLVKSSESLFFGRGNEMAFLFPREFIVGDFHDTYPRENIFRLLFNNLPREDCVLNAKQLMVLLIQTIQKFPDNPQAKTLSERYHKCFDGILTYSRHPNMSQSYSQTAIMNGLKNAFQGLVHNGEPVKIGSRPATSFEAGAYTNGSVLRRMPLYAFGMASLWPMISLWKLEDYEYLEYRPTLIRMAGASRRRPHSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0H2</accession>
    <name>A0A8H7Q0H2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_006685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0H2"/>
    <dbReference type="OrthoDB" id="2369992at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2183677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="758" mass="86799" checksum="579B2FAAFD2A0305" modified="2022-01-19" version="1">MSTSKHRVPRNRPCEECRQHRRKCNLPFGESRCERCTKQNLKCEFKYYKRAKGGSHGSTELDVSEMNANVEYLERQVQELELAIRIARAQMDISPNTSTIEYDDIPVFGGDTTYNNPLFEFNSLNPTESELSEYNEDYPTYGNTLTLANSRTSSSTSSSAVDRFMLTPASAFSDFSQSNGVSSDSSQDVVLISPIPSDDDKEDQNNQHTWSITMTKKGLTINTNVKSIQDLVSWGFAAIKILNSETHLSPFTVNLSEYNGDISLAVTSRFHHGTKELYTDILRTNQKKLTFEDGNITQPALIAADAQAVVSSLIETYFQCHNKQILILHRDTFLEEEYDPRSPLSSPQVMAICAFVCLRHCRHMPDYTSQELRELGEFFYRTARDLLEDIFDDHKHRHESMLTLMYLGMFRLQTLRVSEALSATTLAYTIAHDLLPEMMEMPAVDDKSMIHREMFKRQYFFVVMVENQLYHIVEKTSKDIFFSKLSEDMMPLPDEDEKTIKFIKLKNKFHNWMSDPEVKAARKNITQLLGKDNGFNSLSLKNYFTYQNIITELYSQLEPDFKLAADIDTQPTDEQISNADRVQLQTFIIIHVFYILINSLFLPRDLFSNNTTDDVPAAELQSEFANMFLKNISASSLERCLKSSSIVIALAEQQIRHNICRCCRLTLLSVPVEPLYLLLVIDLSMQLAKADRRPEIAEIGHQNLEKCVKLLKDSIFAPMHGVFMDEGRSTTEPSLDSPITQTLKERMEKMLLPFGINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0M1</accession>
    <name>A0A8H7Q0M1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_006188</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0M1"/>
    <dbReference type="OrthoDB" id="2447880at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="entry name" value="DNA Methylphosphotriester Repair Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00165">
        <property type="entry name" value="HTH_AraC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="Ada DNA repair protein, N-terminal domain (N-Ada 10)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="6">
        <location>
            <begin position="258"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2183193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="301" mass="33953" checksum="19F5335776B4E6AA" modified="2022-01-19" version="1">MKELLLEEDTFERALDAYQVVYAAYDSNQLRIARQRRKLVAQIADQSAFVRRIEDWLNSGDYQSILDYGPPSQALPEAAISGYNTFDGDFESNEQIFDGVSDMKLFVDQMMPAWSGSSEFTGSEADASLDTSVDASFDTSLTEPSPITDMLPDSIYDNDEKRWTAVLNHDMDANGQFVYCVLTTGIYCRPSCASRRPRRSNVSFHNTNQDAEKAGFRPCKRCKPQELACPSDMRQMIAVGVVQQEIQLAAQKGRKQPPLSKLAAQAGMSSFHFHRVFKARTGFTPDEYGKRVRAQYQFSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1L8</accession>
    <name>A0A8H7Q1L8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="7">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="7">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MDE1</name>
        <name evidence="9" type="ORF">INT43_006653</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="7"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1L8"/>
    <dbReference type="OrthoDB" id="191080at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000003">
        <property type="entry name" value="Methylthioribulose-1-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03116">
        <property type="entry name" value="Salvage_MtnB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027514">
        <property type="entry name" value="Salvage_MtnB_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="8">
        <location>
            <begin position="37"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2183645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="251" mass="28396" checksum="815F28A2847FEF9F" modified="2022-01-19" version="1">MATHDFVGVEPLNPARIHGSENADGLCKSEDPLHPSNLIPELCRLFYTNGWVTGTGGGISIRKDEHVYIAPSGVQKERMKPEDLFVMTLANKQLLRKPTLYKPSACTPLFYNAYTMRDAGACIHTHSQNAVMATLLYPGETFEISHQEMIKGIRRGNTKSNLRYFDKLVVPIVENTPEEEDLTERMAEAMKKYPDTCAVLVRRHGVYVWGESWEKAKTMCECYDYLFEIAVKMKSIGIDPAVKPESEPDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q225</accession>
    <name>A0A8H7Q225_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q225"/>
    <dbReference type="OrthoDB" id="2153609at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="163" mass="18842" checksum="7C03ED7F863AF8E2" modified="2022-01-19" version="1">MSFAILPTEIVLMVLHNLDTKDLWAVERTNLRMRALALWDVRRRMNIITTSWQLKINSEMTCNLSKGEFDMATKSMVYNVPQEIIQLDQAVRDIYCILFRTISEQASVWHDMARLKEEGMLSSATSNAGRYQVDADVRRSEGLCKVMVKSIKVPIREFRTLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2C3</accession>
    <name>A0A8H7Q2C3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GHMP kinase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_000551</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2C3"/>
    <dbReference type="OrthoDB" id="1924968at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047940">
        <property type="term" value="F:glucuronokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053034">
        <property type="entry name" value="Glucuronokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38710">
        <property type="entry name" value="WITH PUTATIVE URIDYL PYROPHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38710:SF1">
        <property type="entry name" value="WITH PUTATIVE URIDYL PYROPHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="3">
        <location>
            <begin position="382"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2184638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="638" mass="71526" checksum="6E5C351A018ACA06" modified="2022-01-19" version="1">MSKTLVILATTSATTTLEKDIKNEHTSRFLRYRGVPKCLLPISGRPALSWWYDTAYHIYEHIYIIATAHSYKHFERWASGHAFPKENILNSGFSQGAISDISFAHRVKDIAEDLCIVPADLLFDNSRGLRLLETLKQAKGNQIIYHIPEHGDDPRIQRITTEHGSGLLTKEDTENVKKSLICPLAYNMGSSSLKQLDSYLRLPDHQASDVSLSGSITIPSLQEDLLAFYETQEYVQTIEQEFVSAYGYLDPSVTLTDYLKTWEKLLDTNIPPRSPKTFPNHQSQPIITRSNARVGLMGNPSDGFYGKTMSLLISNFWAEVTLIPNPLTQVEYGSISILPNPVADPHLFSSIESMAVISQTDGYDNGDRLLQACCKVFFTHCQKNNIKIDVKQGFSVLFETNIPRQVGLAGSSAIITAFWKTLLKFYGVTDEDIPLPLQASLVLSAEQDELGISAGLQDRVIQAYGGLVYMDFEKQHVDQYGYGQYERLNIDNLPPLWLAYVADPKDSGKMHNSVRQRFANGEPAVVEAMRQFAQLTTDARDALEKRDHKKFASLMSQNFNTRRAVYGDAALDKANLRMIQLATEHSCVAKFPGSGGAVVGMWNGDDEAHRNQDLQELRWALEKEGFVFVEIQPKANDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2V7</accession>
    <name>A0A8H7Q2V7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2V7"/>
    <dbReference type="OrthoDB" id="2344490at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2184525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="376" mass="41593" checksum="722EF8AE2DC44339" modified="2022-01-19" version="1">MFFAKLKISLDTDAAMLCTFDRCHVQPTTTGATIGLASLIAINYITLALVTYFHFSGISRQHLASNLSYTVGMGAIETQRQRQRHSLAEPINILTPNQPSSMRGLYPPSSAIGFDMPSPALISATMPQPKRKSEKSLTMYNTVHFLQHTPTTIYCICTLSGFQAWWVYFLFVAGFHIGGIAKAILFHQQHRGAVKETRTQRSLPGRSLAVPTTTVHPPTSELERPVPTWLGSENRLSHMWASNSTLATVNSSDQTMSTNHRTPSFTIQNAYQFPVVNNNDTVTRHSIYPATTTYPFRHNSASFGTTSDSSGAPSAVASRRNVDVAPLTLNESSKNIINQRASAPMNMRLDSDDDDDDEDDIEPLQAQRAERVSMRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q374</accession>
    <name>A0A8H7Q374_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q374"/>
    <dbReference type="OrthoDB" id="2020070at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604:SF1">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="983"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2184483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1040" mass="118780" checksum="A24F2AEA25A14401" modified="2022-01-19" version="1">MSTRHSSGLHKRTPSQAKYSIEESTYIDKPTTAIPATKATRTKNLWLFAVFSVVAIYILYKYSFQHDLISGTDDKRRESLLTQALLEDSMESDGQAKPSWMDDMGYRNKLEYPQALQRDPKVGHSMIEIQRLESNGRLQYTNSLHRIVSVTAILAIDNSIDVRSQVAAVLSQTVRPAHIWLIIDKDVHLPIAVSREKLPEYVGFRVFVREKAADRTWLSIANMATTRHTWFLTNGVRPGVKYLQRLLRLSQTQEYTHALLGTEGVILPLAENTTLADADDMVCLPQAIETGELPNQSAAVDMLADIWLLRREWIPIIMSYTTPELLQIPIGFRISLTLSKAGITTIALPINPVDQGYWGDIREHTRTLHNEGSLSCRQRKEEYSFNSAWQRILDRNQYTLVAEIRELTYQARAQTDIIFIISTAEELQALSPIMCSFIQQGKLVHLINSGTQSLYDMQPQQTLYGHNGCKANHVHDLSIDTKYWTEEDIVFAGTHQIAEIHDLLHILDARLVIYAKEHAIWQDVIHPDIGIKSVLIGLPTADLAHIGWLATLSLETLQEWNTVDINLFVVTDSRPDALSRLLRSMNSAHYLGDTVKLTMNTAHTADKVTQVLVKNFLWGHGQKIVRHRIRRAGFMKALVESWYPSSVHEYAIFLDDDLELSPYFYIWAKFTVLKYRYSEHQDTLKNMFGISLYSPPGLDLHPDGLKPFIPSELLDPDLYPMETPYLLQLPSTWGALYFPEHWMEFHDYITGRLTDDHGKKRQDIQIPESRSNEWRFSPRRYMIEMIYLRGYSMLYPNFNNYTSFSTVQWDAPPHLMIEQNETYHAQVPLMDKNTILDGLSGNALPDWHDLPIFDYLGMPTSVVELQEKGRILQRDVSACDPGVAGTSRFDPSDLLCPFPIILLEEEEPKNKTTEETNVKYVTIYVVGPAPTIEVEDSNIDHWQGQDLPNDPLNNHYEEQAFEELTRNMESQLQMDGNDEAIDDESQEQAAADTPDGTVQSQTVRDDPHEAVNAADTDNQNPDWTEDTTVEAELKIEADVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3Z0</accession>
    <name>A0A8H7Q3Z0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3Z0"/>
    <dbReference type="OrthoDB" id="2384695at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2184873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="230" mass="25914" checksum="7C8371EAD7B6A90F" modified="2022-01-19" version="1">MDCSRLYPSPTIFESYPNSLYYSTYSHTAPHYGIDYNTYNEPCLPIFGFPSYSVPEPLTPVFSEPSVVSAVTITEVPSRKRKRANQSLQGMLNHLHVTEFFYQNLMTDTNFPFVPKDSPKDQKKTHPTAPQKANSAAKSATTINEITVLENDLGYLQDSWASIHIVLDSLKNAFLVTPFEGANEQQLDELDRELGIAYDDLMIQVRQLDRALKQLDGKISKLQVSQPACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4D4</accession>
    <name>A0A8H7Q4D4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mediator complex subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002722</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4D4"/>
    <dbReference type="OrthoDB" id="2286203at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021640">
        <property type="entry name" value="Mediator_Med28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11594">
        <property type="entry name" value="Med28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="111"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2186284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17542" checksum="83C2E605503A4362" modified="2022-01-19" version="1">MAAEQNLLALIDSYASEFAACLGTILPDTPGKIKDSPTIHTDLKKYVESMTSITTSMEEKLEQVRLSTLQDKEITLEQSVASLKRDIVIKTNTIEKYTKQLQQWSKELQELEDRGRSVATRENEAHKSKDIAAESFTEHQDNSDDESDKEMFEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4L9</accession>
    <name>A0A8H7Q4L9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein YTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">YTM1</name>
        <name evidence="9" type="ORF">INT43_000867</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4L9"/>
    <dbReference type="OrthoDB" id="10251381at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="8">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="100"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="141"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="190"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="260"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="302"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="347"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2184954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="425" mass="47209" checksum="01553DCC4D86A7BB" modified="2022-01-19" version="1">MSMAETELEQVQVRFTTQQQEYAITESAIFVPANFKRYGLSGIVNHLLGKDKPVPFDFLINGELLRTSVAQYLAANNLSTENVISIEYVESMLPPTPVSAFQHDDWISSVKGKHTSQLFLTGSYDSMVRLWNMSGECVATLEGHADAVKSVAFGSITDNEAVVFSSSLDQTVMAWTYSFLDSTYKVLYQCKGHKGAVESVAVDSSNTQFATASADSTLRVWATRDPSEEDSIEYLDTKNKKRRKTAGQDSHKIKTFSQTLNGHVGPVTSVIFDNNNSNTVYSGGWDHSVRMWDVEQQVNVTTKNCEKVVLDIAQSNQSKMIATGHGDKVIRIWDPRTDDSVAVNMTLPGHSNWVSSVSWSPNSEFTLCSGSYDSTVRIWDIRSKGSLFTIQEEDKSDKVFSVDWDGDKILSGGEDKKLNIHQAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q500</accession>
    <name>A0A8H7Q500_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_002426</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q500"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000778">
        <property type="entry name" value="Cyt_b245_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF69">
        <property type="entry name" value="FERRIC REDUCTION OXIDASE 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="10">
        <location>
            <begin position="272"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="361"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2185988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="596" mass="67231" checksum="3641C793F9DF2FA6" modified="2022-01-19" version="1">MFETSFKSTSEFLQVRTNFGTEIVPAYPRVNPLTCEQAHRLHIYLRRRTLTTGKDVTPFKPFPQWQRTIHKTIAIPFVTESISIKHVMYIVGLLAINLIFIFCAPFTVSGGYMLPVGDVSNRRCVYVGLANFTIAFTVITRNSVLSKLASFSFDELVPFHRWYTKIGLAECSVHIGYQIWKGYNKFGNAKDSLFYDMEYQSGTIAALGYIILYLTSFEFIRRNYFEVFYYSHLIGVLMAVGATFAHQYGAIAFLAPGVFLWVVDRAIRFYNSNYTQTETISVEAAANQPFTRILFRKENLEKSFVPGQYVFLSIRQSKGVRKVFDTLNWHPFTISEILPAYSKHEKDQLLERGKFSEVIKVTDQEKSSEEPISSTPTSSPTAVSETGSDNTAYSSGVASVHIKDLGNMTRRLFANAQTDASQLEVSVDGPFGSNSLHFQDYETVILFSAGVGVTPSLTILKDLVERRSKGYSTVRTKTIHFLWSLRKSEHADAFVSILNSCNKLVEQSVQPLTILFQLFVSEGEASDKAGLEDALGQNVVVHLRKADIPEIMEDLARQHTTERVAVQTCGPAVFMRQVQNAAAFNGWSIRTETFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q557</accession>
    <name>A0A8H7Q557_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">nicotinamidase</fullName>
            <ecNumber evidence="6">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_002516</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="6"/>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q557"/>
    <dbReference type="OrthoDB" id="1739143at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01011">
        <property type="entry name" value="nicotinamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008623">
        <property type="entry name" value="PRK11609.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="8">
        <location>
            <begin position="5"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2186078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="220" mass="24380" checksum="FAD8B0BE3F9577A0" modified="2022-01-19" version="1">MLEKTALILVDIQNDFLETGSLPVPSATEILPVVNQLIATVKERKGLIVATKDWHPQNHVSFASNTANGEPFKSIEIEYEGQKLSQTLWPDHCVQNSPGAEFAPGLDTSQIDIVVCKGSNTHVDSYSAFADNMYFEITELAKLLFTRHIETVIIVGLAADYCVKETALDARKFGFRTILVKDGTRAVVPDNFDSCMETLMAKKVEIVKSNDETFKAELLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5J4</accession>
    <name>A0A8H7Q5J4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent RNA helicase DED1</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP-dependent RNA helicase ded1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">INT43_002644</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5J4"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17967">
        <property type="entry name" value="DEADc_DDX3_DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000397">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044763">
        <property type="entry name" value="Ded1/Dbp1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="22">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="165"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="21">
        <location>
            <begin position="367"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="19">
        <location>
            <begin position="632"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="19">
        <location>
            <begin position="681"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="549"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="663"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="708"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="17">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="581"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="672"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="713"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="746"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAG2186206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="872" mass="94303" checksum="47BF93ACFDB91DFC" modified="2022-01-19" version="1">MSGWGNESNNTPSTDWSQETQSYTSGGGGYNNNHDRPARSGPPQNRGYGGGNTGGGDYDQPPRAPPSNYKWASSRRRYEWKDSYNEDGGIAPRDAELEKELFGEENHVNTGLNFDKYESIPTSVRGDNPPSPIDRFEDCDLHAVMKENISLARYSTPTPVQRHSIPIVTAGKDLMACAQTGSGKTAAFLVPTLSALFGRARELSNPRPMNRFDARGYRAEPLVLILAPTRELCSQTFDECRRFCYRSMLRPCAIYGGADSFPQKIELEKGCDILAATPGRLQDFIARGKVGLNRVKYLILDEADRMLDMGFERSIRDIVEQSGMSQDRQTLMYSATFPRAIRKLARDFLKPDYLFLKVGRVGGTTNLITQKVYWVEEEEKRERLKKLLLSQPPSRTLIFVETKRGADSLDQYLYDQSFPTTSIHGDRTQMEREDALIAFKNGTCPILVATAVAARGLDIRSVMHVVNYDMTNDLDEYIHRIGRTARVGNSGLATTFFNDANMPIASDLTKVLQENKQEIPEFLKDYMTTDLTFAEDMDEDNVDLPSYAKQGLRRGDFDGSQNRGGPNWFDNNNNNNNNNNGHSNQDTGGYGNQNASGYGKQNAGGYGGGGSGYGGESGGYGGGAPRGGPPSRDGDWSCPDCNASNFSRRNECFKCNAQRPEGSYDNSAGRNGGERPRREPRPDDWNCSACNAVNFSRRTECFKCNEPRGGNSGASYESPASGNNAAPSWGDQTTSWDSSAPTSGDSWGAPISSAPAPAGGNDSWGAPASSSSAPATGNDSWGAAAADSGDGSWGSSPAPAPAAQSPAPVAAPAQKAQSPAPAASSPTIQDISKGVENMAVKPQAENGSSGDGWGSSNNSHTGGGWDPTNTPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U6S4</accession>
    <name>A0A8H7U6S4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_008151</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U6S4"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2171771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="185" mass="21220" checksum="95AD818E126EDAD3" modified="2022-01-19" version="1">MYSLNDAQVQARQQKVDLDVELSKYKVFRDLEAQTKISKVYIFLGGLGLLLVLIIFNIAGELVTDAIAWIYPVIASFQAIDSPTPAANRQWLTYWSIFGAVKMLEYFLNALLYWIPYWFVIKTIFFLWLSLPQFTGAEVIYNQYKQRVSNGNGPKIDTFKAKVSQISTKNKDIFSPKSPKSQKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U6X3</accession>
    <name>A0A8H7U6X3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U6X3"/>
    <dbReference type="OrthoDB" id="2744543at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="125"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="275" mass="31087" checksum="81BD594EDAD2D5A5" modified="2022-01-19" version="1">MEMCKLFATAVEDTPEYLALFNVDNPMHHQSNFTCRFRLQDENDIHRVIRDLEQKYHKDNLVSRFFVDELSTPSMDVFEAHFKSLGSSYTITHCTDVIMKGKRPDQSIDPLSMVKNLEAHQATSASTKTATKVDLEALVRVFAAAFDNQDGTEWLRIKLAKQLDMSEEFKATVTQIHTTSGETIITSVSTLYLSPTHPDLALLQIVASDPKYQRSGLAGASTLKLLQDFAGDRTVYLEVYDDIPHAQKLYQQLGFEVAGQFKFFRADGVQTTHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U723</accession>
    <name>A0A8H7U723_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial potassium channel ATP-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ATP-binding cassette sub-family B member 8, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Mitochondrial sulfonylurea-receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">INT43_000186</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U723"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18574">
        <property type="entry name" value="ABC_6TM_ABCB8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000215">
        <property type="entry name" value="ABC transporter B family member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000403">
        <property type="entry name" value="ATP-binding cassette sub-family B member 8, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF17">
        <property type="entry name" value="MITOCHONDRIAL POTASSIUM CHANNEL ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="19">
        <location>
            <begin position="164"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="18">
        <location>
            <begin position="485"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG2172836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="733" mass="79826" checksum="CB307D05CC1AECFA" modified="2022-01-19" version="1">MLARTVLRLGHVQPAHATCKSILIAAKSTQFGSLNLKPQNVQRLCSGTPFSTTSAGTPTFTVIARQSQVSQYLKKASPSGASLAPTLTTVFGTIGAYQALKFTRNCHGKVYCDAGILQDPYVRPMAISVKPIYEDMEKAEKHEPKTSLWVEVWRLVKPDILLLILVAATAIGAAMVNLQTPSVTGELINVLAQSIKSSESLSMQELQKPAMKLLLLFLSQGFLTFSHISLVSTLGENVAARLKSTLFSAIIRQDISFFDSHKSGELVGRLTTDVADFKHTFKQIVTQGLKSIAQSVGSAVHLMRISPSLTFTLISTMPVLYAVLNLYGSYLRKLSKHGKEYDGIASGLAGELIANVRTVRAFAAEENECKHYQAATDKVAKSNTHLGLHIGLFQGLTNVSIGCMALIVLYYGGSLVVKNEMSGGDLMTYMLSTQATQKSLVSLGVLFGQSIKAVGSANRVFEFVHATPDVPLHGGITLPDLDGNIRFDNVSFYYPTRKEHRVLDGFTLDIPKGTMIALCGPSGSGKSTVAALLERFYEPCSGEIYIDGYPLSQMDPSWIRQQIGFINQEPVLFAASIADNIRYGRPDASDEDVREAARQANAEHFIEAFPEGYDTMVGERGTSLSGGQKQRVAIARAILKNPKVGDIDHEDEDEATSALDTHSEKLVQEALDELMKGKTVLVVAHRLSTIRSADVIVVMGREIGNVIEKGTHEQLMKKKGMYFGLHNNVEMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7L3</accession>
    <name>A0A8H7U7L3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7L3"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034690359" description="Peptidase A1 domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="57"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="88"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2171710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="412" mass="45352" checksum="9688A664308BA001" modified="2022-01-19" version="1">MKSVKAFVSCLLLVIAANSFPISSPQLKNIPLRHLSTGLGKRDIHGQTLYHEQPLAYLIDVGIGTPPQYFTLTVDTGSSDMWVPSTACSTYSECPGPKFDARKSSTFVNSSIPFNIVYAVGAEKGTYGFDRIQIGGYNITKQSFATADTARNNTEQPKPTPYTQGIVGFGPYDGSSMALISEQHGSKPFIYTLHQDGHIPNLCFGLHLGSIYNQNYSGLLTLGGANKSMFHGEMDFIKVAPYESLDGEKRYMSWNALINSFAVGDNTYKLDKDPTPFTLDTGASFSYLPDSIVKTMVTKLSAEAQLGNNSIWYLPCSLLNSTKTLDIHFTNSTKRPVSSKSTYSIPVSSLILPKYDDNITSCFFGIISAKSMDQYILGLTILRHMYLLFDLEEMSIGIAKPVLKDFQPYPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7W0</accession>
    <name>A0A8H7U7W0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_004806</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7W0"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="1"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="431"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="568"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="668"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="747"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="82"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2172265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="973" mass="108821" checksum="6DEED354F6A5BDB8" modified="2022-01-19" version="1" fragment="single">MQVALRVRPLSGAEQSQDQTQCVFCDSADNTITVALNSSYRSFTFDQVLDDSYNQQIVYDRCVTPLVDKFIEGFNATIVAYGQTGSGKSYSMGTASTDSDPGIIPRFIHHLFAAVPDAQISTTFLELHNEDLIDLLNPSAKNISIREDPQGNIYWIGAQEQSTNNPEELLSVLQKGLIARSTGATDMNQTSSRSHAIFTVILKQYISEDESSCDSANDNGGKVAHHLRQVESKFHFVDLAGSERLKRTKAVGDRFKEGISINSGLLALGNVISALGDETRKMSHVPYRDSKLTRLLQDSLGGNSQTLMLACISPSEMDVVETISTLKYANRARNIKNNVVRNIEQSGNDTDRYRRLIGRLKVEIAEQETFMNAAITEMDSLKEKLNVVCKEKEMLSSLVSDKSDNSNISQALENYAHEIEKLKQENIKLRAKSDQNVKNNDTSAQDKQHSPRRPRKRKSLRQPNRNSILRNTPARSTTTDELQGLSAIDFDGLLRHRIALETGDKPTPGFIPQAVNDSLKVLDSLKKSIKGANSRGAARSDHVALMTQAQNQIEQDIRVLLQLLSNSDENPSANRSSKQSAPKIASKSSDNKQRVLLKENQNLKQKIGELTKQHSDIKTKAEESQKKLQSQSNDFKQEKRKLLKRIKQEADRSKEKQQNLEQQIKMLQKFEDGKKRAESSVARERAAKSRSQEELQKCTSDLQSIASYLTKAIHPNVEVDRQLLNNLSVPASARSCCVQQKYVTPSITNYRLKLNNLENELNTLLSERKMVVEEELEEAKKSGTLFDSTQPIYMDERVEEVMSDINHIKNVIQALEVTVTEMQKAQTNMLEAFGKLDYSDARKVSTSLIKSLDSEEAVALLESLADEMVELQGLRSTQTALYNCCQSEQQQLKLALATINQKISQSVRIARETTAQKIDILPGILLLSQEVTQMYAKAHNIDLTYRDTDSDELSPTPATMSRSLSMLAIPTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U829</accession>
    <name>A0A8H7U829_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRP9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_009088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U829"/>
    <dbReference type="OrthoDB" id="360923at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.10:FF:000008">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.11, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039914">
        <property type="entry name" value="SRP9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834:SF12">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP9" evidence="2">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="111" mass="12713" checksum="FF0B913366F2D598" modified="2022-01-19" version="1" fragment="single">MYLDTWDDFQKAAENIYETSPERTRYLSSYRHIDGELVLKVTDDISAVKYKTKQSTDLKKFIGLNRSLMSKMQNIQHSEAPQIAEANNQPSQNTTIASKPSGKSKKSKKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8M0</accession>
    <name>A0A8H7U8M0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_005384</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8M0"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF171">
        <property type="entry name" value="PEROXIREDOXIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2176151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="206" mass="22769" checksum="BE02E98F09D52EC0" modified="2022-01-19" version="1">MPLLNNQSCLEQLLKSNTPPLSSLLPLSLTVTSRISPLTTSRLGQYVVFFWYPMDFTFVCPTEIIAFSDRIAEFKALNTAVIAASTDSEFSHLAWVNTPRKQGGLGEMKIPIIADKTKSIARDYGVLIEEAGVALRGLFIIDPKGTVRQITINDLPVGRSVDETLRLVEAFQFTDEHGEVCPAGWQKGDKTIKPDSKASKEYFESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8Q7</accession>
    <name>A0A8H7U8Q7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8Q7"/>
    <dbReference type="OrthoDB" id="2340007at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="220" mass="24712" checksum="3074AB94C025E658" modified="2022-01-19" version="1">MFDSPSKRCAWLAYSLAYIRASILLVSAVVMTTGLLHYTTATHMAKNHDSPKELLASLFANAIEDRRLISTLVTAHATSVCSLLVLIGQYRQSDEVLPRYKSVFVQLCQIVVPLELMVSWIFCILFDVHTKLVYEKRNSLYTQSYSGICIATSEENAAIQCSMVTLTYTCKYVVCSLLFAELILVSIRAQQKLKDQGRICLVDNVDDDAQILKLELDTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U938</accession>
    <name>A0A8H7U938_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_004221</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U938"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF2">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2174200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="397" mass="46923" checksum="54A45929B03EA43E" modified="2022-01-19" version="1">MRSLLSRKTLITLAFVAVFIFLYRIGDHPRIVNTMQPTAYYDKYDEPVCLPEQHISKHPPPEKAKAAMVVLIRNNEQEQMVGTIKNLEQRFNKNFNYPYVFLNNDPFTEEFKEAMKLAAPHASMEFGQIPQQHWSYPSWVNQTKAAECRQKMDAEGIYYGGSESYRHMCRFNSGFFFKHHLLDDYDWYWRVEPGVRFYCDITYDPFLFMQKHKKQYGFVITLLELKDTIPTLWDTVLDYAKSRKIDLGMTAIAGKGKSKSLFPYFLDENNGYNLCHFWSNFEIGSLNLWRSSNYQDFFSYLDQTGNFFYERWGDAPVHSLAAGLFLKTDEIHYFEDFGYQHDKYRHCPSKESGKGCRCECPAGTSDASIDHDKYWDTCLPRWREWEKNSKKLWGGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U944</accession>
    <name>A0A8H7U944_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U944"/>
    <dbReference type="OrthoDB" id="360390at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="228" mass="26225" checksum="AE036798C941BC0D" modified="2022-01-19" version="1" fragment="single">FAGCTGLFILNGVILIVAIPIWKSYVDFVITNYKSQAGISDEEDEDVQVKKLTDDELQELTEETRKELLAACSATNYHIAESHRIWNEYMDFEQLLMKQSSTPESVQKIRALYLDRLMSIHMAWDQTFENFSTFVSSHDNAQYEETMVAVNQQCSSIKQAIGEREIIESELVQKRYDLNVLHEYLLKEKRAKTAPSLSQGLYERAVAVHCTDAGLWEDYVLFQVSYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U979</accession>
    <name>A0A8H7U979_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">agmatinase</fullName>
            <ecNumber evidence="5">3.5.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_004373</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>agmatine + H2O = urea + putrescine</text>
            <dbReference type="Rhea" id="RHEA:13929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="3.5.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="5"/>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U979"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019627">
        <property type="term" value="P:urea metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000006">
        <property type="entry name" value="Agmatinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF30">
        <property type="entry name" value="AGMATINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034520341" description="agmatinase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2174350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="384" mass="41199" checksum="E189584F7AE008F6" modified="2022-01-19" version="1">MAAKIVFGLSLAAATCQLILGFPASAINYGDHELRTQRPIAPKAPERPKGDGEVTADAVFSGVGTFAHLPYTQCWANQTADFDIAFIGAPFDTGTSYRPGARFGPAGIRDGSRRLNLYGGYNVPMDVNPFSDWAKIVDCGDIAVTPYDNTFAIDQIQNGHQELLHRKPASATSKFSRVITLGGDHTITLPLLRSIHSAYGPISVIHFDSHLDTWKPKVFGGAKSDVAAVNHGTYFWHASQEGLIKKGSSIHAGIRTTLSGPSDYENDGNAGFDIIEARDIDTIGTAGIIERIREVVGDNLVYLSIDIDVLDPAFAPATGTPETGGWSTRELRRIIRGLEGLKLVGADIVEVATPYDTNAQVTAIAAADIMYEVMSLMVKTPLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAA1</accession>
    <name>A0A8H7UAA1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA damage-inducible protein 1</fullName>
            <ecNumber evidence="6">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">INT43_001137</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable aspartic protease. May be involved in the regulation of exocytosis. Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds ubiquitin and polyubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DDI1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="6"/>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAA1"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05479">
        <property type="entry name" value="RP_DDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01796">
        <property type="entry name" value="Ubl_Ddi1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000499">
        <property type="entry name" value="Serine/threonine-protein kinase KIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033882">
        <property type="entry name" value="DDI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046409">
        <property type="entry name" value="PDC10_dimerisation_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019103">
        <property type="entry name" value="Peptidase_aspartic_DDI1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036353">
        <property type="entry name" value="XPC-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09668">
        <property type="entry name" value="Asp_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101238">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="23">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A2" evidence="24">
        <location>
            <begin position="197"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="22">
        <location>
            <begin position="363"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="391"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="663"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="777"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="671"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="709"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="741"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="792"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAG2175490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="870" mass="96310" checksum="E2EA35C96ED81336" modified="2022-01-19" version="1">MRISVTTDEGDLYNLEIDSQMEIENLKALLEAETNTPSSDQVLLYHGNELKDPQKTLQQYGIGEDDIILLRRNAPAGSSNPNFDMMRQHVLRDPRLLQQLANTNPDLAQAAMNDPERFNMMVQQIEQSRRQAETQKSAQIAALNDDPFDIEAQKRIEEAIRQENIAANLEAAMEYNPESFARVTRLYINVEINGKSLVALVDSGAQSTVISPETAQLCGLDRLLDTRFSGIAKGVGTAKILGRIHSAQMKLSKDFFLACSFIVVEGKGSELLFGLDMLRKHQGCIDLRKNALTFEDIDIPFLQEHELPEKQRLIELHGGADDETPAEARIAGPVANANASKYGESSQSQPQPQPSAATSSSSKYSENDIATLTNLGVSRQEAIHALDMAGGNCEIAASKGSFGEVFKGIDRRTNRPVAIKIIDLENAEDEIDDIQQEIAILSQLDSQYVTKYYGSHLKGSNLWIIMEYCSGGSCSDLMKAGNIREEYIAIILRELLRGLDYLHTEGKLHRDIKAANVLLSSGGDVKLADFGVSGQLTASLTKKNTFVGTPFWMAPEVIKQSGYDHKADIWSLGITAIELAKGEPPYADMHPMKVLFLIPKSQPPVLEGPYSKHFRDFINVCLQKDSTRRPTARELLKHRFIKGAKKVSYLTELIEAHERWLHMGNGKDSDSSDNEENADEPDDEGWDFGTVRQPATVQPPHKAQAFGLKQTSSTTGLSHLQHSSSMQNMQYGQPTPRPAGNRQSQPGMKQSNSSVNQITGGIQRLNSRYSMDDYGQDTVRAKDSSNDVPRPSVLSNSISSSNSSASMKSEAIFHDTVTSIISQLRKNSRSQRGQAALENLVHAFDLVEREQPGSTQTLVEETIRQLHTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UB50</accession>
    <name>A0A8H7UB50_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cleavage stimulation factor 50 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_001926</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UB50"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005848">
        <property type="term" value="C:mRNA cleavage stimulating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.50">
        <property type="entry name" value="Cleavage stimulation factor subunit 1, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044633">
        <property type="entry name" value="CstF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038184">
        <property type="entry name" value="CSTF1_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44133">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44133:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="163"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="273"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="324"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="52"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2179076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="423" mass="46580" checksum="5747816AC5250E3F" modified="2022-01-19" version="1">MNNLPESQVLPLIVSQLIAYGYSAVAKQVADATGAETDMLPSSKLSEYLFYGKEQAENDGSDSEFSDKDSDDEPMKEDKQETEDASDPSGLSFDDSSPTPKPTPEYTQMYYTQHKGPCLTAVFSPDGKLAATGSHDASLKVLDVHKMKHRTGDVGDKPVIRTLYDHVAPVSDISFHPNGNVLASCSEDQSIKLFDLSRHGVKRAFRYLKVTKNLEIEKKCKDTPLVNAIFQDAQAVNSISFHPSGDFILSGTTDANVRIYDVKTFQCYTNKSSNVHRGGITQIRYSNTGKLFATSSMDGSVRIWDGVNSQCVRAIERAHGGAPVSSVRVTKNEKYLLSAGGDATLKMWEISSGKMPTMTYNEDYVMIGDEGSTDVLCWDTRTGALLKRLPGQNNNVRCVVASPIDDAYLTCSDDYRARYYVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UB70</accession>
    <name>A0A8H7UB70_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_001986</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UB70"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058855">
        <property type="entry name" value="RGS1/SST2-like_Fungal-DR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25889">
        <property type="entry name" value="WHD_Fungal_DR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="DEP" evidence="4">
        <location>
            <begin position="176"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="443"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="604"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2179136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="72748" checksum="C84A2A343E030F04" modified="2022-01-19" version="1">MPLDTHRVLFRSYPCTFTTDEAVANLGNLKFSHTLRSRKGLKESSVTTTTTTFSMTKDMAKALLTQFLDARLFVNASDSANRSLKDKGVWQVTPKGLCILEGFVDRSVVDGSHLNLLYAHVRPIKVIDIERANADDALVLTRSILTVILKTMMGFLPKGSPDSSSSSLSNQSLSGKSKQVDFKVEVDTKITADHSFTGSLFADWISDYTTVVDLAEAEAVGNELMLYGWMEQIADEVDRRLEDTTIFKSTKYALYHLTKTGKNLLTGSSELNDLKSNMIANATIMARDKLAARTDKNRISSSDMSSDSIEDGEATLQEMLANDKLAIIAEKQRVKKNLLDNPRSMVRSGSGGSSPSGNSDMTSIHFANEIQQASKRGNVPPPAPTRQKHSSIGDRGRTIDLSTGRRLSSSNIDTRSIASTNSITSLNEGDTHTMDGKDSNYTKLGQILEDPHLRQLFREHLKANFCEENICFWMDYHTMRRSIKGSISSRSLDQQKELLIEAYQIYSTYVAPGSSREVNIDHILRQEMDQFISSISTVVTSPFVNAPFQNADTSTVILTTSNPANSLRMLIRMLDKVDDHVYRLMAQDSVPKFIRTEKDKEALDLDTSKRDSGNGSESSSQPATPPATLSDTLADRKHKAEYSAMRSAVSPIIIRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBA8</accession>
    <name>A0A8H7UBA8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_004708</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBA8"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="13"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="10">
        <location>
            <begin position="222"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="730"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="730"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2173334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="833" mass="94463" checksum="2915C5399CA460AF" modified="2022-01-19" version="1">MTPSEDNDKQKRFKVGRACYTCRQKKIKCDGLQPCMQVLRRRPCSFAKDGKTDAVDWLENGDSDYETKEEIPPPQRPRQESVQGLARTYKRSFSDIDTTPRMDVLEKIQPSPNLFVRKHLLLAYFKFRHEVFSILPRKWLLRDNIDSDPFVTPLLLNSMYAHAAEHIGREITGSDEPMRGSTFFTQATNLITEYLESSLSTIVALCLISIYNEDSKASISKSWLYSGIAFRMATDIGFKTPEDKDLEQLGLELRKRVLWGCYVLDKIQSLISGKQWMISGHSVELDYPAPLPDENTLDHAVLDGFVALIRLMQICERVLHFEFFIAPHSKEHEQASLDLSHELLNWLRMLPAHLQWTPLPQAPADIPLQAPSSAMIANLHMCYNIVEMRLLHPYATTLDNKAIRSRYHAVANTIVQLIDFVYEDPTIVITPYLIVYAAESCAQFYIFDLKHSERGSREQTKENLSRTLRALRHLHETCGIAEAGRAVYKLEASLKQEVSRFKNVASLAEQLPMTVPHPGGEHIPTAMNGVFTKDMVEQSERSPPVQPRYHNTVPQDQRHDVVMHGLRASSDPVFNTPQPPSFEHRGIDPFAFDQLQVDAGQAAWDVQAMPTADAPENSPVKLHNYDYHLNGQNLPRRIRLFTPYPTYNIPQPSSRPTMADSNLVSDNIHVSPVSVPNHASAQPSNFTLSMTPDSLDQQPTADQLLTMESAMSHHGPWDPSNKWYQQLSMDQANTASREQLDRQSYSEPATPALDHHQKPYRGIGLGVYASAHRHHTDVIRQHAPEEGNHQSSTAPESIALDAPDAFDQPHAGHERHKSQEVMAHHMRFSQQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBN5</accession>
    <name>A0A8H7UBN5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_007644</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBN5"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF32">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="105"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="295"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2176990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="604" mass="66473" checksum="BB75871080FFC549" modified="2022-01-19" version="1">MLQRRLAATLRSHAFKRSYSSIGVFPDLVKDKTVQITNSRGVNVIHDPLLSKGTAFSIAERERLSLRGLVPPRCQEMDKQLARVKANLDACETPLSKFVFVTALQDRNETLFYRLLIDNLEELAGIIYTPTVGLACQKFHSIYRRSRGMYFSTQDRGAMSAMVYNWPQDEVDVIVVTDGSRVLGLGDLGANGMQIPIGKLSLYVAAGGIRPKAILPVVLDVGTNNEKLLHDPLYLGMGHPRLESEDYYEFVDEWVNAVKARWPNALIQFEDFKYPHAYNLLNKYRDEITCFNDDIQSTSAITLAGILAALKARGKKIDDLAEERIVCVGAGSAGVGVCEGIVDCMVAQGKVRTREEAYSRIWMLDQYGLIGNSAIADGEPNRIGQGPNRPGKLDERQRSYTKMDLPDRISLEEVVEKVKPTVLLGLTGVKGAFTEKSIRTMAQHTEKPVVFPLSNPDTHAECSAEEAFNWTNGKAIFASGSPFKDVTLPNGQICKTNQCNNSYSFPGLGLGITVSRATKVTPTMFLETAKTIAELASPAQLKEGILFPGVAQLRQVSCAVGTRVCEVAYEEGVASAKLKEGEILSEVVKASMFEPEYVPLVYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBV9</accession>
    <name>A0A8H7UBV9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBV9"/>
    <dbReference type="OrthoDB" id="2437185at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="408" mass="42767" checksum="BA8E4D08B30CBE19" modified="2022-01-19" version="1">MVNNEPDLLNIFGVIAAAEETKPAAPDTSTTKVEPKTTTTPKPVVKTTTTAAPPPAPTTHTTPKPSTSVPPASSTHSSVVSSSVASSSVPVSSSSSIISSSVAPATSITFVTPTTSSSSPLPTTNAAASTHSSSSNTNLIGPVVGAVAGAAVLLGVGILLYRRRRGKREQNDADRTFSDYLAGSEAMHGSGKGNWDQTYNARNSTNMRSPASIAAGIHQQPSPRMMPAVGGLTAGAIAASQQNWSTSSHQSPDNTLVGSPQMSQMYPGGNYGHYDYNGYYNQQPEYPHGQGYYEYSADPYQYPGNYQPYFDPESEQYVYPPSGSEAPAPLSSASPTQAPNTYDQQPQQSQTDYRTSPLPAPPRSAHSIRSSVDEPRFPTYGPASQAAHIPEPTSSAVHKPDSSTAGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBX1</accession>
    <name>A0A8H7UBX1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spindle assembly checkpoint component MAD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_003687</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBX1"/>
    <dbReference type="OrthoDB" id="331602at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008672">
        <property type="entry name" value="Mad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168:SF0">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05557">
        <property type="entry name" value="MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="45"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="792"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="845"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="270"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="399"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="798"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="854"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="868"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="884"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="896"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2179901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="933" mass="107116" checksum="AA14AB40BF54E044" modified="2022-01-19" version="1">MDGDPANIDRSTQNLLESSFQLSNALTNGEADSDHNIFQSAATESLQRLTNHSTKRPRLTRESVFRFGRSRPQADTMPASPSPPPAQEEKLAEVRTLLDELRLQLMAVQSDKAMLESTFAAEKAELLRSIHEVVDGKTEAESRAVYHFQQVDQLKKSLKEVQNDFDELKMQKETERRKLSTENSEMKEELQSVKREFDSARQDWQLKEAEYKREQERMNATIEVFNIQNQQSSDLLQAQLEETTSTMSRLAECEKQLQTYQSLDLNPDHIKSLEEELHSHVSNAHRLERENGTLTRDLRHYKAIYQNVEKLREEKYALEHQLRSMTIFKDKAMRLEVENAILKRERAEWASFLENAEDVGFTTPYAVCRELASLRSDKSSAASLQESITELTSNQEALLADAEKRIIELHQQVREKENLRQVDQVNSNILVKDKQLLQKEINILREQLKSYDIEEITYMSDRYDSAKSQRLNELEGLIGQYRTEIEALRTMMTSERTRALQNQTGQNEESTPTLLDLPTGNQIKASLIDATNAKINLAKELSVMQSDLKFKTIELGALKKQADILQNALIIGGVDEAVLRSIAEVQPATANTATEDTLMIEDDQPKQRILQFKDNPASREQAIRQSLLDNLRKENQELIARLQQGLESNDMEDDEGQPQLPNQSFVNLQSENERLHSIIAQKEKRILRMQQVWATKVREYHEAVASLLGYKVDFSADGMVRLASMYADPNDISFVFKSSENDQGTLKIVGANKDDYMKTLESSYNYCVVERGSIPAFLSAVTMELIDYQKHDDGDHEMLEEDEEDEVYGDEDEDDEKIRIFGEGEHSGYNEQNDNPNYVMEEIDESSEDNVYAESDRSDVEQQKYAEDEPLQEYVDTDEEVEEDLHTGSDEFDHDSFDDEEEDDDGDDDDDEAPVVGQEEPIHYVIDDDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UC40</accession>
    <name>A0A8H7UC40_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ran-binding protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UC40"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12909">
        <property type="entry name" value="SPRY_RanBP9_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035782">
        <property type="entry name" value="SPRY_RanBP9/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="104"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="443"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2174114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="743" mass="81815" checksum="2E66C2A834F0BCBD" modified="2022-01-19" version="1">MSSSFLSLPPSAIAVNAPENTSPSATAYSSAFPPLHSIPLTTSQNKNKAWGTLYPPKPSLLPPKYPAYLKNTNYSRLADEQYHQQCRIKKASKPIGAISSLFNKSEPSIQYDSALEQLDLRLPSHWTPNEKNSSAIVSPDGMDITYSGLGRDETDASSVRSAFSAKSQCGVFYYEIDIVSKGRDGYISIGYCEEDTPSDKLSGLDSTSYGFHANDGKCYHGLNVGTAYGPSFTTGDVIGCGINFGANTIFYTKNGVYLGTAFNNIHVDTPLYPCVGLRTPGERIRANFGTMTFQFDIVQYMNEENRRLQTSISNTPITPTATNKQISSMLTAAWMKQIGKSAVEPATPPKTAQQSAATSEILDQLVYSFLLHHGYSQSAKLLHKNVKETKDVDLASEVFDANQDNIDNDVHKMDELVHRQGMLVCTVNISSCLHQLNQLFIDIRSAVIAGDINAAIKLTQAYFPQVLSTDELLLFRLRKRKFIEMLRAAHENSIHPMCDSGFIQNFHTLSTTYEENDSTHPHDMAMDKAPTVFGTPRKLSLPAPLPQAPASDIPQPARRVSYASITATPTSVSPPHSVQGYFGRSFDDTNSVEEPSSPTGYFHTRRRRRSSSHVSFTSLSSFEEDDEEKLEFREAFRFGHLLQEQYGRDQRPAVKAGMAEIMCLLSEADSYNASHLASKAFDISGRDVLAGDLNTAILVSQRKPAAPPLELVYRQTATTVKELVRHGHGQAALVNVHDTVCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UC50</accession>
    <name>A0A8H7UC50_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_004164</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UC50"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000383">
        <property type="entry name" value="Dynamin-like gtpase dnm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF235">
        <property type="entry name" value="DYNAMIN-RELATED PROTEIN DNM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="6">
        <location>
            <begin position="23"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="5">
        <location>
            <begin position="628"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2174144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="715" mass="79981" checksum="EF12394EA39ED253" modified="2022-01-19" version="1">MENVIELINKVQDVFSTIGGNDSLDLPQIISVGSQSSGKSSVIENIVQRDFLPRGSGVVTRRPLVLQLVTLASSEDQEQPQEYAEFLHIPNKRFYDFSEVRKEIEDDTARIAGSNKGISRQPIHLKIYSPKVLNLTMVDLPGLTKIPIGDQPTDIEKQTRNLIVDYISKPNSIILAVTPANADLVNSDSLKLARQVDPEGKRTIGVLTKLDLMDAGTNALDTLTGRAYPLKLGFIGLVNRSQQDILTNKPMSDAIRSEKDFFLNHPSYRSIAHRCGTAYLSKQLNNILMNHIRDKLPDIRSKLSTMIGQTQHELAQYGDMGLSSKLHRGSLVLQLLTKFANDFVASIDGTLSDISTKELCGGARIYFIFNNVFGQALESIAPCANLTDHDIKTAIRNSTGPRPSLFVPEIAFDLLVKPQISLLEPPSLRCVELVYEELMRICHNCGSKEIQRFPRLYARLVEVVSDLLQERLSPTSSYVESLIAIERAYINTNHSDFLGAAGAMAQLESQNKKHRALERKRAAKMSQINGRIEQTEKETLQVQHTHHDSAHQLGTSPKGDSFLTYFFGGANKHERPALGSMDLAQNSVSPPSISKVVEAEMERQLGEKLSLKEQSEPSQGLQRDELEVKLIRSLITSYFEITRQTIHDLVPKAVMHLLVNYSRESVQNRLVAALYKDELFAELLHEDENLAQEREKCKAMLDLYKKAFTIINDAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UC96</accession>
    <name>A0A8H7UC96_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI anchored serine-threonine rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UC96"/>
    <dbReference type="OrthoDB" id="2273964at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034954886" description="GPI anchored serine-threonine rich protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="18672" checksum="07961F971BA9A61E" modified="2022-01-19" version="1">MKAPLCLSFVFLGLIGSSYGCANQAVYDLCLKTGQAAMNMCGSPGTNARCACAAQKQILACYSECPDDYNVFQLGQIQGGQVQIYCSMPGAEEPIKKEVTTTAAAAMATMASPIHASATEPQATGSGKSTANNDHVAIQSGTATNNTTNLLKPLKNGATAQALIQKGSLFGLLGVAILMAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCP7</accession>
    <name>A0A8H7UCP7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Core Histone H2A/H2B/H3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_003353</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCP7"/>
    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000006">
        <property type="entry name" value="Nuclear transcription factor Y subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="9">
        <location>
            <begin position="40"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="192"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2178100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="237" mass="26225" checksum="8DECDD5DC99C4459" modified="2022-01-19" version="1">MSEELPHSIINAGTAPGAQPVFDLAKFWQEQLSLADNFDSDFKNHPLPLARIKKVMKTDQDVKMISAEAPILFAKGCEIFISELTRRAWIHAEENKRRTLQRSDIATAISKTDMCDFLIDIVPREEQQQSQQGNAGYDQQNTYTAAYYPQAGFPQYTAQQIDPAAYYPQLSQLTPEQMQQYQLQLQQFASQAGAPTNTQHAGQGVATNQGQSAGGPGAGHNQLQKAGNTRSPSNDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDG2</accession>
    <name>A0A8H7UDG2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_001081</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDG2"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09487">
        <property type="entry name" value="SAM_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051965">
        <property type="entry name" value="ChromReg_NeuronalGeneExpr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040:SF3">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="149"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="149"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="238"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="367"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="254"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="308"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2175434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="487" mass="53136" checksum="987A2D4F5B32C059" modified="2022-01-19" version="1">MDNTSDPASSEQEIRDFLSNCELGQYADVLIAEGFDQLKSLFEIIESDLEAVGVKRGHRRLLQRAIASARGYDPNLPLPTNSHVSSRSSATSSNSPTYNPNGRHLTVVDVPRVDSRQDAISSTEEDNFSEFARSKRKYRRHAKADKNAPVKPPSAYVMFSNQVRSELKDYNMSFTDLAKIVGDRWKSISPDEKELYERTATKAKEEYLNALAKYEKTDEHKDYQQYLIDFKMKQQAAARAVGKPRKRPKTASPSSGSIADASNNSNGNNGGDTSSSSNGNSISINDHNTPTMASSSMPPSERSGAATSDSGIFSNSNSSSNFDSFGASENTSSAGPTPGSSSTDYRHQSTPYPIQKVNTYHNPYKTHASARISPNTSGESSESRSTSDHSRFLDPPTPNLYSGTRPYFTVIPGQMHPQSPYTPVKTVETRPGVHPLTQPPSSGGGRYQKHSVVRSDPSSMDRARLPPLYGGSSHNGRRDTDSGSPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDZ1</accession>
    <name>A0A8H7UDZ1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-amino-N-butyrate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_007093</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23352"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="2.6.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDZ1"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000029">
        <property type="entry name" value="4-aminobutyrate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004631">
        <property type="entry name" value="4NH2But_aminotransferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00699">
        <property type="entry name" value="GABAtrns_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2182166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="507" mass="56252" checksum="F1CFA30999146BEF" modified="2022-01-19" version="1">MLRSLKNLKTAPIQRQLARSTLAYQPVRTLATAVGSGRIGTHANEKSFFPDEPQQPQVKTAIPGPSSKEIMQRLNQYQDTRSVFYIADFAKSKGNYIVDADGNALLDLFAQIASIPIGYNSPAFLALTSSPAFQSALANRPALGVNPTKDWVDAVEQAFMSVAPKGMSNVFTAMCGSCANENAFKAAFMYQAGKRRGDKEFTMEELQSCMKNQAPGSPDMSVLSFAQGFHGRLFGSLTTTGSKAIHKVDIPAFDWPKAPFPQRKYPLEDNVEHNQKVEQQCLEETERLIKTWKSPVAAVVIEPVQSEGGDNHASPDFFRKLQQICIKNDVLFIVDEVQTGVGATGTFWAHEAWNLPTPPDMVTFSKKFQAAGFYGHPKLRPAQPYRLYNTWMGDPVRAMQAAAIVREVKDKDLLQNVSRVGEYLQKELKEISRKYGKIQDVRGQGTFIAFDLPTAQDRDSLIGEMRKNGVNIGGCGDRAIRLRPMLTFQMKHADIFLDTLEKSIAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UF87</accession>
    <name>A0A8H7UF87_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UF87"/>
    <dbReference type="OrthoDB" id="2117972at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027948">
        <property type="entry name" value="DUF4436"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14494">
        <property type="entry name" value="DUF4436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="380" mass="42450" checksum="1280698475B11592" modified="2022-01-19" version="1">MKIIEKLPLKSPKGRIWLRRLFPAVIVIAILVTIVGELASQKCIPTWQIYTEESRQGTLVSYQEPNDRGESLYIQASLMDVDFTAKTYKIHFLLEPNGTLAGDNGVVSQNLTLSLYSMKYIHFPAGESMEPVEIVFDYDFGNDVDYPFDQYSGYFEIMAAMTGNISATVPISFKLEASVTTYSFNPSFRQFNYETDKIGLKIVAGRSTTTLGFSIFICILMWALSLVIALISYQVVLRGRRVDAHSTMLGITMLFALPALRSAQPGIPPVGCAADILGFYWNMAIIACSAVAITMCWAVRWRPEANDKMSIMSVEEARFDDTHYDDTRYDDNATACGSTCPPVRRCVDNVDDDIYEIGDEDSTTIAGSSPSTSPDRRRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFD5</accession>
    <name>A0A8H7UFD5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">homocitrate synthase</fullName>
            <ecNumber evidence="5">2.3.3.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_007966</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>acetyl-CoA + 2-oxoglutarate + H2O = (2R)-homocitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58884"/>
            <dbReference type="EC" id="2.3.3.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:12930"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.14" evidence="5"/>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFD5"/>
    <dbReference type="OrthoDB" id="2015253at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07948">
        <property type="entry name" value="DRE_TIM_HCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.260:FF:000002">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000032">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02222">
        <property type="entry name" value="Homocitr_synth_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048253">
        <property type="entry name" value="DRE_TIM_HCS_fun_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011872">
        <property type="entry name" value="Homocitrate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02146">
        <property type="entry name" value="LysS_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF48">
        <property type="entry name" value="HOMOCITRATE SYNTHASE, CYTOSOLIC ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="15">
        <location>
            <begin position="41"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2177309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="433" mass="47573" checksum="FD6EFC88F293C3EA" modified="2022-01-19" version="1">MPEQTNGHINGNGNSADRPREPIVSPYQPKYADPMSNVSSFKIIESTLREGEQFANAFFDTEKKIEIAKALDEIGVDYLELTSPMASEQSRQDCTAIANLGLKAKILTHIRCHMDDAKVAISTGVDGLDVVIGTSSYLREFSHGKDMDYITAKAIEVISFIKESGLEVRFSTEDSFRSDLVDLLSIYKAVDKIGVNRVGIADTVGCANPRQVYELVKTLRGVVSCDIECHFHNDTGCAIANAYAALEAGATHIDTSVLGIGERNGITPLGGLFARMYTGDKEYVKNKYNLHKLRDVENIVAEAVEVTVPFNNYITGYCAFTHKAGIHAKAILNNPSTYEILKPEDFGMTRYVSIGHRLTGWNAVKNRVEQLNLDLTDEDAKAVTQKIKALADAHGALSLDMVDGLLKKFHEAKEEGTHKEVLKNIESPAQITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFK0</accession>
    <name>A0A8H7UFK0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="4">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_008757</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFK0"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000276">
        <property type="entry name" value="Acyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="15">
        <location>
            <begin position="8"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2181175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="226" mass="24352" checksum="717679C1A8435926" modified="2022-01-19" version="1">MAASLKSVLIQPKAAHTGTVIWLHGLGDSGAGWSFMAEHLARQFPTIKWVLPNAPNIPITLNGGYRMPGWFDLSSLSFTEKMIEDEKGMLSTVSTVNQLVRDEVDNGTPSERIVVGGFSQGSAMALLTGLTSEYKFAGIVGLSGWLPLHSKVISMASDANKKTPIFMGHGDIDPVVQFTYGSKSADLLKSKGYNVDFHSYKGVVHTASDEEISDVAKFLSSVLTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGX5</accession>
    <name>A0A8H7UGX5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGX5"/>
    <dbReference type="OrthoDB" id="2390504at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2178794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1092" mass="121222" checksum="8A5467483BF19300" modified="2022-01-19" version="1">MRFRTLAVQKHTKASSSTEYRDIGSSNLPDSVRVDKGSRQVAAVPRSGRSTLRHRRGPRPGKRFGLLRKWLARGALIYLSYATLWQCPSHVDKKGVLAPDSPYICSGINEVKSDFQWVFNHPVYKQHVGQHIDPYWKQANEHYDTYAGPVISKSKHYGEKYGIPAAQKAHGAYQQYMRPVYAKANDHAKQQYDRHAKAHVDRYYSEAEQQYKKHIAPHVDYATKSAQQVHSSVRKFHSEKVVSFNKQAGARIEQGYNAVKPHVERAVQQSVHVYQNNLKPAAIKASKHSADYYERTFKPTALAIIDTIWRLIQEYAYKFKVWSVDVANKGYVHGQEVYTKHAKPYYDQNIAPVVSEKYKAYLEPTVNDAKKFIVTHVDVDRVQRGWDTVKQHSGTAYRYTEEQALLGAAIAAEFVKQQHQKFLESRHRASEAAKAAKQDAYLSASSVVKQASKAVSEQESSVIAAGVQATQAAADMKDKAKGAVHGFASEALQFARQAQTKVFDAAENVRAQASKGSDAAFSQFEKAKHAVADGVHHGVDEVSNLVNQATGKVKSAEESVASQATSLASTVKEKASSAAKKPNSIASSITSVATSIAATTPIDVSLTTSSATYATATTVPSDGLFEKVQDQVVITGEGLGVSRNNDAAQTIAAQFREATEPEKDNISTSAKASPAEQASSKAPETEPMVPIVVPEASMILKPEPVTPIGSESEANDSESLTETEGPAEAPVNDLPELQPKGADDLTPVPPNDVGDRADGSEFKQAPIRYEEKSYLNNIVSVQIEEIITAADIIRTQLEEKYDEIERVQLENLQRVSDTSEEETDSQVSQLVQSFRDYYESQAAESTVSHEDKLKSMEEKYQQTLNSVSDVLLNQRSDSSKFSKQAKSEMSAAQKDAEAQIRQKFKEGMHRLRSGEKDVTGLNERQHRELQTKLEDAQVQALKLVHSAEKAIEVEQKLLKARTNRILSKLDRREKNIKEQLEHWLEQAHHVLSIADPLVDLQASAVEADLEGFEIEHQPVPQETSLAEPHDDVTPVEPVAEQVQKELHHRQLVDEHIRKAQEKAARVAKTVEDWVEAAKRKSARTSAASSFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UH32</accession>
    <name>A0A8H7UH32_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UH32"/>
    <dbReference type="OrthoDB" id="2376984at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2178944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="48504" checksum="453C102372672EBB" modified="2022-01-19" version="1" fragment="single">RQNLLQDGECLNVNSRNENLGWQTLQPDDWVYYPQQMVNVSLNPAQVSLNTVGGCCAPNPRKQFSNVYYDDGSTYQESGNKIVGIVDAPMVQNILVEGWYMQSFVDNNSVNLTLLPSITLPDKTSIVVSTVIDRAMIITYQFLDKNNRRIANLSSGVLRNQFYIPDVTLPAGTRSVQLAFYSSQTNPMCFGFIYAGIYVDLSRTTIVKFCAIASNRLQYIALGNFILIPSIFAVMKTFTAFHFPDPLRFLCRQKCHPILLCLFVMIGSFIFNGAWNLVRSQSNMFDSWLPRAMKIIELFISFFLYAVLFYPVSYQNRHAFLCFHASQRSRIANIFGFYTSLCLFSLRISIDLPYYAITYAREPGFLLLNVMMAFVTLIAFLAVLGYFLKNSLLFATCDICQSSFADAGSIEEQYVQELLNRKFEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHB9</accession>
    <name>A0A8H7UHB9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002019</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHB9"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="7">
        <location>
            <begin position="118"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="270"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="312"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2179169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="373" mass="40465" checksum="AD3BC8908CCCD836" modified="2022-01-19" version="1">MFVPTIKGSKPESVSKLSDDIVSLKIDAASLEPTKMSDTKNVQEKDDSSNAQVTSQARAADSPSTVSTPSTVSKPSTVSSTPATVPSTPSDNEITTPDTSETTEVETLKDKGSVATEPIPIVEEEEAEASITVAEHDKDRIIVTLPNGTRYEADRYCPHAGADMYTHGQISLDEYGPEIGPIILCPMHYWEFLLDKEGNSTNGWATLDACQDLPSGTPPSNFDIPTTIVLYVCVILVGVGMCFCLQRANRLLPNGLNFALQPTALRRGRSRGNAASFPDDDIEAQQGLLNDDDDISDVEDETYRRRQAAIQRDDQEYEADEFGELQEAPNPDSNVKGTAEELDESPEATGTRARIFSIQDDEGSDGEAENRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHM9</accession>
    <name>A0A8H7UHM9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_007004</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHM9"/>
    <dbReference type="OrthoDB" id="10263554at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="6">
        <location>
            <begin position="374"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2182077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="492" mass="56916" checksum="E2D8BFE2E055327C" modified="2022-01-19" version="1">MADNTDSVPEVPLALVSNSFLEGKIAQMRNRPVPWEGYQRANLITSEQFDLIQRIDKKSPEEVKALVDERGDTYANLYLHLLDTLNRPDTIQHVLLLIDNFLTGEISICLLAWRDPNFSDIHRYFIDHEEHVRYFHEASKKNSSYPFEPLFKYASIFLASLSLIVHSRNMNHRRHLRVNDDFVPLQASKILTIFACSASSPASVDLSPYFSWVATQLQGDDLRLVDLVVQELESVLRVREYRLTFWNTTKAPEALINILRRVSPGPQMQYQVIFCLWLLTFDSQIAATINRQYDVIPLLVDIAKSAIKEKVIRVVIATFRNLVEKQPEANLAAMLVAKLLPFTENLSTRKWSDSDILEDIEYLKNELQENFQSLSTFEEYSSEVETGKLTWSPPHKSEVFWKENAQRLNEQDYRLLRILARLLSTSQNPLVLSIAAHDIGQYVKYSSKDAKKIVQEIGAKQRIMELMTHEDQDVRYQALSAVQKYMTNAWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHV7</accession>
    <name>A0A8H7UHV7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_007229</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHV7"/>
    <dbReference type="OrthoDB" id="2406597at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0137">Centromere</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="6">
        <location>
            <begin position="18"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="433"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2182302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="741" mass="84790" checksum="A21351823BA06AB7" modified="2022-01-19" version="1">MTTTNVTTTIIIPHKISNTIDVAQYLDRMDDPITHYDNEIRRILKYHSSEDVRHLDTQLLSVLKAAIFYIQKQERYRNDPRYLRIWLMYAAYYDDPMHVYSFLARISIGTYLGAFYETVADYLEKCNRCLEALTVLSVGVLLHAEPQKRLKQKKLACQAKHASVIGPKLSDELHANSMSTQPKHNSHNRLFTWDEWASESSEQILRQYQLIMGAPASDNHREKGHEWWDAVAWPKASTPKKSVYLKSSSGNHISFEESRAKKVGYLDQNFSQGKTAVKQTVLTSLHQGRDIHKSSRGLERFRSSPNETSRIASAQAADMNCDSLQRIIGALSPLGSHRERNLCTAHKCEQTNTLKGQNPQKVEASTRNLLSDAVVMDNEFFRRMAAAAKDLLYQDQNYINRTSEAMPLKSKFRLIHSFRAFHKFMLKLSPYSLSVTAFIAQGGNAKVFMATDMDGSVHGMKIESPPSAYEYCIIKSLRTALGSVASSYIVQPVSFHHYKDAGCLLMEYCSQGTLLNAVNLIRKAKMDNQSTTGMDETLAMFLTMRLLQIVIALHQHGFVHGDLKADNVMVNFEVVNENIATSSSMSTKYVGKDDAYWSLKHIKLIDFGKAIDTNLFPKGQRFLKCWQTNKHDDAPQVHANKEWEPWIVDYWGMAKTVHCLLFGLDMQVSQKCGHYNICQRPKRWWDEGFWNKFFRVLLNPGVDLPITNVLIAFQDELKTILTDRENKNRLRHSVLQLQQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHZ8</accession>
    <name>A0A8H7UHZ8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioester reductase (TE) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHZ8"/>
    <dbReference type="OrthoDB" id="276721at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF16">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="1">
        <location>
            <begin position="136"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="247" mass="27587" checksum="901D11BAE9889572" modified="2022-01-19" version="1">MSNNRLAIIGKGLVASAIAKQAANSNVYGSVNLVSRNKPTQEMDMLPNKVSHVQGNALYPSSFSDTLRTASAVVSTVGTIKDEKDNEDGSYERLNRDAVVSVAREMVKTQPDDLDKRCLVYFSAANAPPGFLLDPRYINSKREAEQTLLSKEFQDKLRVVIFRPGIIYSMSQRKFMLPIAVETMIMSAVLRPFRHQLPDSLQFLADKPLSDDIVGMAVLEAIKKSDVEGIVDVHQMQELANQWRKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIR2</accession>
    <name>A0A8H7UIR2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIR2"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051332">
        <property type="entry name" value="Fosfomycin_Res_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36113:SF6">
        <property type="entry name" value="FOSFOMYCIN RESISTANCE PROTEIN FOSX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36113">
        <property type="entry name" value="LYASE, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="6"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2183232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="140" mass="16247" checksum="DC859787583542BD" modified="2022-01-19" version="1">MSTFKGIHHVAIIAQNYEVSKHFYTHTLGMRIICETYREQRQSYKLDLQVAEEGTPSQIELFSFPNPPPRPSRPEAAGLRHLCLAVEDLEKAMADIKERDDRNLIEFEDIRVDELTGERFVFFADPDDLPIELKQVGKTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIS2</accession>
    <name>A0A8H7UIS2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome biogenesis protein NSA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_006266</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NSA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIS2"/>
    <dbReference type="OrthoDB" id="18388at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22857">
        <property type="entry name" value="WDR74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037379">
        <property type="entry name" value="WDR74/Nsa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038">
        <property type="entry name" value="NOP SEVEN ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038:SF4">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2183262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="407" mass="45492" checksum="BCB0F9938D383E11" modified="2022-01-19" version="1">MRYFTGDESGLVKSIVFPLPVVEKKVKKQKSQTDKDEEKPKEGPKTQINVFGTVNKEEAVEKMAWATINDEKMLVIARKNGKIQFMSPEDGSIIRELIDENVCVGAKKEGTFIGLSVEDDLLFTASSNGQICWTDLNTDTKTTTVITSLGKDLTCARLHPQLGHILAVGGKERELTLYDMNVLSGKTDAITGIETSSTNNTTKYKKQKENEKGQIFQAKNVKNDYLDLRVPVWITDLQFVNAEATMIAVSTHYHQIRVYDIKAARRPVLDVEVGKTPIKRMSVGVTLDQVLYADTTNDFGAVELKHGKVVAQYKGQTGATTAFCSAIDNETKETVVVSVSLDRFLRVHETSSIHRKLLNKAYLKQRLTAVLVDESYEVEKPVDEEAKEEDDLWSSMSTTSSKRKNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJ04</accession>
    <name>A0A8H7UJ04_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sec39 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_000823</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJ04"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013244">
        <property type="entry name" value="Sec39_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922:SF2">
        <property type="entry name" value="NBAS SUBUNIT OF NRZ TETHERING COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922">
        <property type="entry name" value="NEUROBLASTOMA-AMPLIFIED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08314">
        <property type="entry name" value="Sec39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec39" evidence="6">
        <location>
            <begin position="217"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2184910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="999" mass="113425" checksum="6133987EE37F5C0E" modified="2022-01-19" version="1">MSKETILALLQDSRYDEALKVAQSEDGISADAILKEQWLLWQSQPNTVSADRAVTVLNRITDKAWVVKQCMSCIFDDYNIQEALVNTGVNATQPIVDKIINDILLKDQDTTSFRAALDDSSYTVTVPLSDLDCSWILSKMYLLQYSDRLRTFEEIWSATNVASIDTLPSDDDDNPLNSSTEMLTSSSIDTSEHQYDDNTNENGFGSGYRLFRDVNLVAQAIEFARLQNFTALDILFSRHGTELLPYRLHILSQIPETADPERYNTPSVQPASSACENLMESTWDVHPWREDIDVVEHPKLKEYLKNLKPSLEVYESNLENVLQSVSYPASAETISQWYIERARRIDEFTGLTSYALKLIQNGSMRQVPNLQDLEDNLEFLCKLLYGTGVTAETERLFRDLDLQAFESMDPYEVLELSLKGTGVDRIVMDLIVFGLPWLQLVENRRTRDADGDAHMSEANDFEEPVHYMLYRWLLNVADGHLDWCCEILESSKPTMEQEDRIIKEDLDLSRIALAILYTTEDGSQVELMGRIFECLPLFDLDNLEDPQEEENLEVDTLADIQTAHGFFAALQKSTEKTLSMLMDKLQVHLSSAEVLWRYQLNVPLRWYLQSAESYDEQKQLCLRLANQVVSNVEKNGNRYMQDDDWTALLVDMMDLQDQGNGVLGAMSEEEIFEIYWKALLRCGNFNLAKATLLPKYGSKPISIEKAQQLIVDASREYFDNSNSGNMYHGNMKLASDCLNVVPTTAAIKQEANLIEATHHLTTEFNVFYRPGIPIMPMQVRQSKNRLELISRLLSSNSGAYRKSARIIDLAKKLGLQDDKSTEIRVLNMLSAAALAEEDYETSYKLCKTTLAKVVEVESEIHNSKLIVEMKEITWSSCFQLGKLEVYQDKTKRLELLAMALILCPADRLSENLSAWRKLEARAEKEADNTSGASASPQQGGWNTVSNLLQTGLQGQRNLAQLLSNEAGNFMNTSDMSSPGNADRVRKRDLLKNTVSKWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJ24</accession>
    <name>A0A8H7UJ24_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA mismatch repair protein MSH3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 7">DNA mismatch repair protein MSH3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_000883</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJ24"/>
    <dbReference type="OrthoDB" id="2404434at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000870">
        <property type="entry name" value="MutS protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="8">
        <location>
            <begin position="313"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2184970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="574" mass="65324" checksum="0C6BFE82D1D0AB96" modified="2022-01-19" version="1">MGARLLRISILQPLKGKLVSIINLRRYEAEFQGDLSTIETRLDAVEALSSFKDLDKVISMTNCERTWLAKICAAYGNQRDVFEQYIKTSMEEDAGYQKSALAMRNQRCYAIKSGICGMLDVARQTYKEAVNDIYELAAAYCEETSMGMKVRFSENGGIFLCLPSDTLKRLSLPSQFINIVERKKQIHFTTIELLQLNYRVSESLSEIYRHSDRHMALMSIKEIYYLFINDTSFSYIQSLLNDIRKSIHILYNISEAVAFLNMCMAFAHMCTIADYVRPDFSDTMALKSARHPIRERLSSNQFIANDIYASESTSFQIVTGPNMSGKSTYLRTVALLYVMAQIGSFVPAEYACFRLTDNLFTRLPVDDSADTGLSSFMVEMTEISYLLQNVTSNILVIMDELRRATSTSEALAIATAVCEELIGTKAFVYFATHLHELVYTLDAHINVVKLQLLVKMGTLDRQSDIQFLYKVHDGSTNEMFYGLKAAQMVGLPEQIIDRAYNISKTLHDQILQRKNSSELGRISEYYKLLTLTVERLRLLKPATAGDMDLSNNLKSVKDDYQRLLSQLSDVRYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJR3</accession>
    <name>A0A8H7UJR3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_002140</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
    <dbReference type="EC" id="5.3.3.12" evidence="8"/>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJR3"/>
    <dbReference type="OrthoDB" id="255819at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004167">
        <property type="term" value="F:dopachrome isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF6">
        <property type="entry name" value="MACROPHAGE MIGRATION INHIBITORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2185705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="121" mass="13053" checksum="2B1CA4C7538104DC" modified="2022-01-19" version="1">MPSLEITSNVAPNNINAFLTAASAKFSEAIGKPEKVCLVTFNKADQVVYAGSTDPAFIAHIHSIGHIDNERNAGLSKNISAFLTEELSIPNNRGYFFFHDVKGEDTGYAGNTYANLMAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UK37</accession>
    <name>A0A8H7UK37_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_000585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UK37"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004574">
        <property type="entry name" value="Alkb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557:SF2">
        <property type="entry name" value="NUCLEIC ACID DIOXYGENASE ALKBH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="292"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="167"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604574-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2184672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="415" mass="47481" checksum="71E3F5CA2CE41560" modified="2022-01-19" version="1">MEELQPPAHLKSRRQKEIWRKQQLDNLKARKKAHETQTPFRIAERNLQSSLPTPDQPPIVDFVNLDNNTRENRDKIQEVELHYDLHRLCPLFGESDQECPARKQKAYIHTDIDGLIFIPNPFTAAAQRKLVYNCLHNYTQSPNLSNLDAHYDIPTPGVWNLHVTNQKSNNEDSNVDSICRKESPKRQKTDNGYQNSDLVNATDQKSRPDNQNESRKSSNSALKPSELVKKLRWVTLGYQYNWTTKVYDFDNPVEFPSEAGNLSVAVAKAAEGLGYKVNDEYRWQNTYRGEDFIPEAGIVNYYQLKDTLMAHVDRSELNMEAPLISISLGHDCIYLIGGPTRNTTPTAIRLRSGDVMVMTGNARSAYHGVPKILPSAPTFLQPDIKDAQVDDWELYGEFISKARINLNIRQVNKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UK71</accession>
    <name>A0A8H7UK71_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coth protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UK71"/>
    <dbReference type="OrthoDB" id="10267127at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050">
        <property type="entry name" value="INNER SPORE COAT PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050:SF1">
        <property type="entry name" value="INNER SPORE COAT PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034127997" description="Coth protein-domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="551"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2184777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="65300" checksum="0B0A92B81AEE61E0" modified="2022-01-19" version="1">MKLATGLAVVAFALRVTADVTYSVVAFPAAGQSVAVSVGGQQHSLSNSPQYPNIYSGSAPSGNTYQYVLNGNGGAPETTTRTLASGVTSTGNEFFNRTQTVYNVPGLPQAFNPIYNRMVTPFNQSTEVTTIIMYANETGLDAMLKTPKADNIKEIEVYNMTYISSTEKYFFEGVGFQNSGKSTKDFAKQSYKFSFNEFQNKTTDTLWGRKDFKLRADETDPTLMREKLQLDALLASGAATLSGQWTRLFINNEPFGLYLLMDDGSSHFFEAELFDGDDKAPLGVTYQGNAIGEQVQGNLLFLGTDPTKYSADAYTVADNGNAKAELKAFPLGPLMNFTQALNAFDPKTATSASSPGNITKLIDPQHTLIHLAMNFLSGSWDGLWYAASNYYLTQNTAAQNWTIITYDFDETYGNGAPANLANTTYENYVPSTEQRPIATQFLNSPYYKDMFETTLKTIIKRFFKPSIINPRLEAQMAMLKEDIAWDRSLTKKSPGTDNHWTLDNFMTNVKTTSGGMMGIEEWVTQRSAATCQQLNITDTDDLPPLPKPVWGSNNAVSSGNGSASGNGSASPSSTGTSGAQMSSASLFVTALALVSAFALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKR9</accession>
    <name>A0A8H7UKR9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKR9"/>
    <dbReference type="OrthoDB" id="2139939at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044688">
        <property type="entry name" value="SCI-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117:SF1">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="317" mass="37416" checksum="909657EA4E9CBA9D" modified="2022-01-19" version="1">MSGSRRSREDDRDGNRHKSKKHSRRDRYSDEGSDDELVKKARSLIKEITKDDYFIKAAEFRVWLHEKKNKFLDEISSADARYYFGKFVKAWNRFELDQKYYDGINSAQLSSNESTRYKWNFAKAVDQHELDSIRDHVDTMTNSQKINSAKGKEATDSRRVRSNVGPSLPSLSRRHGSGKKHPIYDEDEEDRRDRQRSSRKKEAKERRQKQELVLDEVAPKETGREAQLAKKRAQNAYHKRERSPDVELNESDIYGDDRSSLEHLKRLEKARADKRAEFQRQKTAPIRDKLESYRAKEDQTLAMFRQMAEEQRKRGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UN65</accession>
    <name>A0A8H7UN65_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_002356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UN65"/>
    <dbReference type="OrthoDB" id="2269860at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2185918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="122" mass="13841" checksum="6C842D7B718601A8" modified="2022-01-19" version="1">MTRIVPAVQTKMDQGHPSLWLDEDYKPFSNEFSVSGTTYETMRSTTCGNKTVDPAMEMKEVPLILAWSAANLEISDLEGERIFVNSKGEVAPSFHKHHAERPELQKGLFKPMKKPAIKRHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCJ5</accession>
    <name>A0A8H7PCJ5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_009049</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCJ5"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2171388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="350" mass="38507" checksum="C79C7E438AEF46E3" modified="2022-01-19" version="1">MTLHTVQPGSHVLVTGSTGYIGVHVVKQLLKAGYRVTGTTRSRDKAIKIQNEFKDYQDKLNFVFTGDLEKKGAFDEAVKDVDAIAHVASPVTFSPKHPIKDVVNPAINGTISLLQSAHKYGKNVKHVVVTSSVVSVVHERKDSTPYVFSEKDWNDEDTNVILNWKEGTPFDGVQTYRASKNAAERAVWKFQKENSPAFTINTVLPGLTLGAYLPKPTSRNEFADVFGSASLYLQYYTGSGRDMTSITDTSVFVGVEDVALAHVRAIEKGHETNGERFLVVGGNYSGQLIVDLMRKNYPERKDIIAEGNPGQYPSTSNSVDASKAARVLGIEYQDLETLLNQTIESAKHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCP7</accession>
    <name>A0A8H7PCP7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_009137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCP7"/>
    <dbReference type="OrthoDB" id="274828at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008092">
        <property type="entry name" value="Ribosomal_mS29_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01716">
        <property type="entry name" value="DEATHASSOCP3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2171476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="405" mass="44555" checksum="BC0BB3CE3DD8BE7E" modified="2022-01-19" version="1">MSRRLIQLASKGVLPVYNAQQSVRTFRTSTVAFAKAAKAQPKATKSFKQKTKTQADSGAAAVTAGKNNEMFYKSAPILNLNEFLPEIVTEESVNKIFALPEEATSNLEVFKYPKTLAKEFDLLNKVSLIARQSSLDLVNKIDQAGSDSSKSTRIILTGEPGSGRSSVLLQAVSFALSRKWLVIYIPEASVWTNGSSAYVPVQGTDEFEQPALASNLLQKIKTVNDYILKDINLTKDYHIDRHSAAKGTSLSKLLDIGIKDQYTAQKVIEALLEEVGNTDTPAIIAVDEVNALYTKTQYRDAESQVVDAYRLRLPRTILDYFSGNKQFKSGAVVGAMSDRLSNFKSLGLNVALGLESPDAYTQLPETTIAFANGVERMDIKPYTEEEAKTVLSYYQMAQVIYEGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD04</accession>
    <name>A0A8H7PD04_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_008037</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD04"/>
    <dbReference type="OrthoDB" id="415015at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01897">
        <property type="entry name" value="NOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1190:FF:000001">
        <property type="entry name" value="Nucleolar GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000496">
        <property type="entry name" value="Nucleolar GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024926">
        <property type="entry name" value="NOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038919">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="OBG-type G" evidence="10">
        <location>
            <begin position="169"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="585"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="446"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="552"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="607"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2171657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="636" mass="73152" checksum="6C237670EED5A03E" modified="2022-01-19" version="1">MSLYNFKKIQPVPTSTDFVDIVLSKTQRKTPTVIHKNYNIGRIRQFYMRKVKFTQDSFDEKFKLILDEFPKLDDIHPFYADLMNVLYDKDHYKLALGQVNTARHLIDQVAKDYCRLMKFGDSLYRCKQLKKAALGRMATVMKRQKDSLAYLEQVRQHLARLPSIDPNTRTLLICGYPNVGKSSFINKITRADVDVQPYAFTTKSLFVGHMDYKYLRWQVIDTPGILDHPLEERNTIEMQSITAMAHLRSCIMFFMDLSEQCGYSVVDQVKLFHSIKPLFANKPIMLVINKIDQAKPEDLPEDQKKMIEEIMEKDAATVVTMSCYLDEGVMQVRNASCDKLLAARVEMKMKGQKINDVINKIHLAEPVARDNVVRAPQIPAAAANRPKFDIKDPNRRRLERDIEAENGGAGVFSADYKKRYDLADSEWKYDVIPEFWEGHNVADFIDPDIEEKLEALEREEERLEKEGFYDSAEEIMDSDEEELKATAESIREKKKLIVQAHRAAKGNRNLIPKMVAGRNSTVDDMNDHLSKMGIDASAVMDRARSVTRKRTRSESRADDSVREASVAERGSTLVRDRSTAGLRNVKQKVEADKQKKVSQRRPNLFAKRGEADRDIQTKMPKHLFSGKAAVGKRDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDS9</accession>
    <name>A0A8H7PDS9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_008209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDS9"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10952">
        <property type="entry name" value="CE4_MrCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF98">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034255090" description="NodB homology domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="163"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2171829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="451" mass="47606" checksum="7B0BDF0095CCA35E" modified="2022-01-19" version="1">MFIKRTLTLSAVIAMVSAQSSPVASASGAVGSGSPTTDGLLAQTSPAYLATITPLAGNVNAAPAPGAAIPTGALGNVTIDTSVYPAVWEVPPTNSSEVQAAIAAIDWTKVPNATVHTADNNGDLSFTGYDANTDPYCWWSDTNCVKPKVDYLPPDIYNCPNPGDWGLTYDDGPLNPANPPAPDQWAEPNLYNFLAAANQKATLFYIGSNVLTFPQAAQRALADGLTICVHTWSHPPMTTMTNDQAVAQFYWTLRAIKEVIGITPKCWRPPYGDVDDRIRSIAWQMGMRTIIWDEDTNDWNMPGEGGGNLPPATVDGYFQGWIDARKNGSDTASGHVVLEHELNNATVSMAEKWLPQIKQVFNVVPVHECQNISQPYWESNFVYPTEDNSSSTTSSSLSLAPSAQSTGGSSSSSSSSAEASAAAASQASGAGKIVAGVFSAAGVVTGLLLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEE0</accession>
    <name>A0A8H7PEE0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_004936</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEE0"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2172394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="27969" checksum="7CDF1B325F206BEF" modified="2022-01-19" version="1">MDSEEERGQESETETVIDLSLGSTHEGYKSHSSGLPSRWNMWRLKRVGFKTELVIILGSAVTLSIYITGDISGAHLNPVVTVVLAVFRKFPPKKIVTYAIAQFVGAFTAAAILYLNVAADLDLIDGGHRVVTGQNATLKIFTTIPLPAVDTFAAISSEIVCSAVLLFVTFGLMHQSDPGHRTIQPILVGMLVALISLGMGVNTGPSMNPARDLGPRTFTALAGWGTGVFTVNHYYFWIPNIIPFIGGAIGACLYDIFLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEL3</accession>
    <name>A0A8H7PEL3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycosyltransferase family 49 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_004775</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEL3"/>
    <dbReference type="OrthoDB" id="3056235at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042285">
        <property type="term" value="F:xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051292">
        <property type="entry name" value="Xyl/GlcA_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270:SF25">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-LIKE PROTEIN LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2172234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="61278" checksum="654D7739F4631BB9" modified="2022-01-19" version="1">MSEKRLSGSRPSPSKGSLPHRRASLSLNTTALGVSTATTQSPKLGQVESLISPRRSRDQQKTWFQRSFDHSSSLLHDKPTHAAHHRLPRIFKQRWIQFFVLVYATFSVLLTFAHLCHWTFADNTVPEPVVEMVDWEPKRTYRSNDPASVIDDMTMSLRFSKAFSKALPGTVEYTQPYWRRAAVLPAPNDITLTTWVTSNNYEQLIQIADMWKGPMSITLHIEGNSPKTSPETVDLLDSIQTALSQEPSIVQYADIHLLLTPPSYSGALALSRNSDRNYARLFARTEFICYLPLELIPATNFRETLERNFDSFAPRLRAGDVFVVPTFAYSATESVREDHTWEAAAEDDNEDTGVEEDGEGEQHMTLVHEETIIPRTKQRLLHLVETGSMSLEDRHWPLGSGPTNFDKWRRADNLFAVEEYEVHYEPVIIESRIVQPWCSERFADNGAACLYATYLTGANFWVLPDDFVVRVKEQQQTILSSTETVIQNRLYAKFVWETCVHHARMLDAEGLWNTEKSRHAKASCSRVINSWGKGLVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PF55</accession>
    <name>A0A8H7PF55_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_000159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PF55"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2172812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="68" mass="7823" checksum="4848D6B57E3C3608" modified="2022-01-19" version="1">MQSYTVRPMPWYLFTMMPTVRLCVWIAQPVTDSQPCKTRLLLSSVISDRQTLASCCSAFPQIFRVNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFB0</accession>
    <name>A0A8H7PFB0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFB0"/>
    <dbReference type="OrthoDB" id="2395256at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="781"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="914" mass="103562" checksum="7CE6C56E2C2EFD00" modified="2022-01-19" version="1">MRPRYNYTSPPNQAEQPSQEPSPIQRRPLRQWRKAEPYQQFSSPFQARSSSPASSISTDLGAFLSPVPVQGVQGFRASTPRIHHQPPESISSQSFVEEASIPSPEQSYADWAAHENILSQPQHELTDLEDRPKSETSSWSFADAASINHPSVQGLSNSRPPSRYFSSESEPADDSGPEEGSDVEGEVSGDEEEDEDVIPRPLRHKPTPEGRRSEQSQVSQRHLLSSSFEHPDTTLWQKRGSANTSLLSQRLDRYRKDSILSRLDQLKDSPDQAASPEEGHYPMSDSYRQMESRQSHNSLRSRSQFRETLRANMASRQSDVNSGMRRSQTDLRLALGPHHRRTPLGSRAESRRSAAKFDDENRSKTSTPSQYRGILRQSTRYVPSRNFASSPYSQSQKPEETRSSDLTHIKQSQAKAIGKTLEKLETLLDGDTSVIQESDVKKQASHDERRWPVETYDDPTSAVAKTQHLLERIWQLQRSLDSKETELLDVRQHARWLEEQLQTARRRIDKLEYDAETRHQLQARLLTTESSANQANQRVSELLQMNFKLVQDHEGLMRQVGQQAAITGSLGRETPWRVREKIALSQASGDFTNTRMAEVQDRLRKLWDDSKQLEEYVKERSASRLSTRSPMPDTRMRPRNPSPRLLTQQQNGYQSSDDEDNESTAEDLVDLLKMLKNESEQHRHQLVKTVQLLAANVSGDEDASQDHAVRIPHGLGSLVTKIRKMEHRYEERERQLNKIIGINRRKNKQDVLSWKKRWENETREWPTAVKPLLTQLDSQESGNSGQDSDNNSQGDAEAEEQDEDDDLVAAVGHRLASASLQDFDAYVKSSTLDQQVDTLWLYITMSSATGGGLETIDDSRLGGLDGGYDDGMKAAICSWRNDAKVGYRFGEVGTEGGVFLCDLLINAGRESYPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFD6</accession>
    <name>A0A8H7PFD6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFD6"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF2">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="408"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="804"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="820"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2172893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="837" mass="93453" checksum="3D7C7E085D610756" modified="2022-01-19" version="1">MNFHSSQFPARRLTEYYDPEADIPTLPLQRLEISHPDDFVPVKRMVSVHQLSTNYSNDDTFSTFSSTHSQESTNRRPSKPLPKAPISQEYVPPSNFMSPLTLPQQLSPIVRQAKPVYNSIFGLDEVASTDMYSELLNHSYDTTYASPKQMPSRGNYSSQSTFESSELPESPAFLSPVQSGGIDYFHDDNISVYSSNSHISNPPSIISMRSMEDDSEFLYEQQQQQQEYNMRAWNEEEESVATPDVVLPHLGTMGGGWRLSINNPSAMSDDELSVEDSPADISPVTPQDINIPLRKKQSKEEVTLGIAPVPVDMGRPVSPFWQQVSSPPQSSGQSDYFLQSPDSYLDPSRARSGSPASSIGGSSFNGSHRLSGSDFTYETRSSSPGLNIPHPIVSAVNEVSAVDIRKSWNGNSSEMKSPMNPQPMNSNRQRSSVPPPPANKLELEPVAEKKSRYSIASHSLTNDPSTVKTMRRMANLTKDFKTQMVYAMYLLEVCQMHDKATTGNTPPKSATRERLLKEAIYWIERLAKDRRGEACYIKGLWHEKGLYGYKQSSDKAHKMYQTAAKTGHVKSKFKLAERHEKKGNTAKAVAYYKSATVKGGVEPNFKMAQILLFGELKQKKNPKLGLEYLRRAADLANNTLSEPAYMMGQIIAGEFKKLKIPEDLIQRDHHAAVKYIRRAADLGYPDALDRMGRACQTGDLEQKVDLGRSFQFFEKAADRGQVRAMLSLSKMYLEGQAVEFNDALAFKWCERSAASGLDHAEFALGYYYEMGIGVEADYPRALEYYSKAASKGYEPAAAALNQHDARGGKLASTKHSRSQVGRDRDHVASKDKDCIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFX1</accession>
    <name>A0A8H7PFX1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">INT43_004518</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFX1"/>
    <dbReference type="OrthoDB" id="29460at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0732">Signal</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034571930" description="Autophagy-related protein 27" evidence="20">
        <location>
            <begin position="19"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="21">
        <location>
            <begin position="21"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAG2173145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="297" mass="31808" checksum="280A0C0B74F52A87" modified="2022-01-19" version="1">MKSSLIIAVSVLSAFTAAAPDFCSPGFKPKADSDYKLDLSKLNRPEGFLVSAETSTPPTTTKTEITVNLCGPLSRPENANQDNCKDGTYVCRRIINVKEGNERVTEVQEIAGEIDGSVLNPSFTAPENEQDLSKNGVQYAITLNGGKVLDKTQSTKIVLECDTNGDKNANPPAGPEIKSYENGVLNLYWKTPFACASTEQSPGTPPSDGGNNGGSSGGGGGGMSGVGIFFLVVGLLIAAYFIGGAFYNYKQYNARGLDLIPHRDFWLDLPYLIKDLFSHLMESINSRRRAGDGYVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PG54</accession>
    <name>A0A8H7PG54_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_004716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PG54"/>
    <dbReference type="OrthoDB" id="2383722at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034996416" evidence="3">
        <location>
            <begin position="25"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2173342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="369" mass="42772" checksum="C38EB9AB134E95F2" modified="2022-01-19" version="1">MPQLIAWFLVYGLLLTIYIYCLDGNPRPVVVGPQWGTDNEPQPLADGESIDKSIPIRIHPNLETAEPWLNETNRANAAIVIVAPSKEYVNVQKTIVHLEAQFNNRFQYPYILLSEQSHDSAFQQNIKRLIGERAQFGSMDMGHRDKSIPVLVASHFQNSTDAEKEYLAEQTQLSRFKAGILFHHRLVKDLDYIWLVEPGTELICDITYDPFFYMQSRNLKYGWNMAIKKDNSTVHKMMKYSKDFVETYPEYNIGTSIKVKTASDDSSFCQFGSEMQFFDVNQFSSVAYWRYFEWLDQRLDWLTNSGQAALSQAVRSFVPRNQIYYFNDVGSKSTEATHCPQPKELRKKCSCEKKEGIELQKISCAHDWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PG64</accession>
    <name>A0A8H7PG64_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bacteriophage T5 Orf172 DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PG64"/>
    <dbReference type="OrthoDB" id="2417614at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053006">
        <property type="entry name" value="Meiosis_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00974">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="2">
        <location>
            <begin position="277"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2173263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="391" mass="44786" checksum="1BCA925281192781" modified="2022-01-19" version="1">MLKALPSHSHGPLTTRNTTSARQSCHGVTVNGSPCKQVVAQGFYNADGQIFCHNHQSQARLGNMFLKKRWENGPPRKSNSAPVTGKLKHNNQAAYEKSDNGSMRQLIAQFQRLFHTSSKVKSCSNAEVTRGVPIAQKHLQTQQVRRPVLQPLQPRLPPGVPPRVVSAPSKFPTLIKPPVPKQCQAINRNNGRQCSRTFKDDTETFCFQHRKRSPEELTQTREQVILPNILVKDFARYIPNHLSSHTRKLLYQELCKPLSQSDSPGYIYTYMLTSSSTATHALFKIGRTNNLHRRMYQWVSKCEYVPQLVDCFPRTEDEEQVRFSHRVERLIHIELADRYRADAETCGGCGGTHREWFKVARQRGMSDKDMWLILREVVVRWINYVSRVTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGI8</accession>
    <name>A0A8H7PGI8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGI8"/>
    <dbReference type="OrthoDB" id="10308319at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2173239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="172" mass="19391" checksum="F7DD43344EAA342D" modified="2022-01-19" version="1">MMSSLHKRRRAAGQSMEKFRWGDLWRCRCFILVKYPTSHTLNPQQLKGTQLRFDHLPEHYNPEELCNAFPSPRNDVNIDPMESAVTAPSQGNDDEKIVKPEEFGTAFYGLHALISGAVDLTMSLCRVRSDMGKVVAADDTKAKLPRTASGRSLNDMNMSGQYLETMTTQPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGQ5</accession>
    <name>A0A8H7PGQ5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGQ5"/>
    <dbReference type="OrthoDB" id="2347119at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="257" mass="29232" checksum="CE8FAF9428ED9AEC" modified="2022-01-19" version="1">MYSLEEFPVEILYNTLQYVNTSDLAALIQVNRRWESIVYEVCYKRVQNLMAAGWTVMVDVDIHDTRENASNDAMNDNLMLMTVLDKVEPKTLNLVFNLHEALLYSAKSLQEDTNNSIAVFHDTPSEITISTSFIGLNSAQHRINYSSQLEAIDLYPQQLDQELGSDTVKLTRSNVSTPPARDASVEYKLTRSSRESISGIPEQNAKWLTDSSKSDNDGQPVVLRLEKFICSLKWFLFNVDSAIMSLDYSQVDQISIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PH01</accession>
    <name>A0A8H7PH01_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_005227</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PH01"/>
    <dbReference type="OrthoDB" id="347657at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01262">
        <property type="entry name" value="PH_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05581">
        <property type="entry name" value="STKc_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000833">
        <property type="entry name" value="AGC family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033931">
        <property type="entry name" value="PDK1-typ_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039046">
        <property type="entry name" value="PDPK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14593">
        <property type="entry name" value="PH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="73"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="403"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="408"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2173807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="593" mass="66231" checksum="22DDF6D42A11362A" modified="2022-01-19" version="1">MASMPAVDSVSSQSSPSASQSDAAQSVTSATATRQGTHESATLHAPMPVTTSAAELSNPDHPQHRHHRNIQDFELTDTLGEGSYSTVRIASTRLKPLSMCMILLDKFHIIREKKQKYVNIEKKALIRMNHPGIVRLYWTLQDRNSLYYVITLAPNGELLTYIKKLGSFDLSTTQFYTAEILSALEHVHSRHVIHSILLDEKMHIKLTDFGTAKILDEEEPVTPDARSRDDEEDPRGRSRANSFVGTAEYVSPELLSAREASTASDFWALGCIIYQLLAGKPPFKGATEYLTFNKITKLEYAFPATFPDVAKDLVEKLLVLDPRTRLGSEETGGVEALKAHPFFDGVAWDDLFTSEAPKLRPFLPKMEGMNENDLTSDNDVFFQNQGHSFEGIARDPFEDEYNSEARVSMTSGNGSITPEDGSASNANKLSLPPSRTSRTRPIAHTSRSNASSIRSGGINSFAEEKLAQDAERQKKLAEQANSPWSKYLHKDELILRAGRVNKRRGLFSKKRYLILTDGPRLFYCEDSKDTNKSAVPKGEIFWTPKMAPELKGKKQFWIHTPHKTSYFEDPEGKAEDWVNAINTLLVNTFGVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PH79</accession>
    <name>A0A8H7PH79_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_005210</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for vacuolar assembly and vacuolar traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the VPS41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PH79"/>
    <dbReference type="OrthoDB" id="244107at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000932">
        <property type="entry name" value="Related to Vacuolar assembly protein VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016902">
        <property type="entry name" value="Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028921">
        <property type="entry name" value="VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="8">
        <location>
            <begin position="659"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="882"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="46"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR028921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2173790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="978" mass="112275" checksum="646E22CF19F3EDFE" modified="2022-01-19" version="1">MSNSGNAAVPEMHSAQVPEEDGQGEAQHRQSSHAHADNITSSGDDKSEDEDEDEEEEEEEEEEEEEEEGDDDDDDEEEEDEEEEDEEPKLRYNRIKSSVAETLAKDAASVLRVSMRFVAMGTHWGAVHILDFDGNLIKSWQNHSATVNDISIDEAEDFVATASDDGKIFVCALYTPEIQSFNYRRPVKSVAIDPEYKNKSTRQFVSGGMAEQLIMNEKGWLGHKDVVLHSNEGPIYSIKWRGNFIAWANDTGVKIYDTATNLRMTYIDRPAGSPRGDLYRCRMCWKDDTTLLIGWANMVKIAKVREKKKADHVQGQPNHYVEIICMFQTDSIVCGIAPFVDNMVILYYVTEEDSDDEEDNADQKPLIASQPELHILDWSGEEISSDVLAVNGYAHYQPNDYGLEFYPTEDMFYILSPKDIVAAYPRDQDDHIQWLLEHRKYEEALQAARQAVENGTPSEKFDIGDIGQQYLMWLMEHERYEDAAAACENILENDQDIWESWVFKFAEIGELKAMASHIPIQHPQLSSTVYEMVLAWLLQHDHKSLLDTLHEWPPILYNVSSVIVAVEDQIEKDKDNVTLLECLADLYTYNGRPDKAIEYNLRLRRPNAFELIREYNMYEAVRDKAVLLMEFDQYLLEEQEKATPDEQTPKKRPTEMPAVQLLIENTQAIPPKKVVQQLKPRPKLLHTYLDALFERDPHLGYEFHDIQIELYADYDYGKLLDFLRASNYYSLERAYNICEKRQLIPEMVFVLSRMGNNKEALMLIIEKLGDVQRAIDFAKEQNDDDLWEDLLKYSMDKPLFIKGLLENVGTDIEPLRLIKRIPNKMEIPDLKQALLKILQDYHLQMSLRQGCEKILVSDSVQLADKMHRTQKRGIQCQVDLTCSICNEPAFEDEDTATIVFFCKHAFHQRCLIEDERIEANVGQVGDSLASKVNYAALLMSSRTMACPICQEQLAKGNGVVHRIAERLEPTASSRIALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHE0</accession>
    <name>A0A8H7PHE0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHE0"/>
    <dbReference type="OrthoDB" id="2312914at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUSP" evidence="1">
        <location>
            <begin position="123"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="256" mass="29150" checksum="784FC2A21BED08FB" modified="2022-01-19" version="1">MLIAAERHVVPGKAAAAATPFQKLNAYSENLLMNAAMLSPAYNPFSTEIWAQIAWQVDSVRDLLALSATSHVLRLICTDDQLWKQLCIEHYALGVCNASKSEQVKVDHMLDVVTKDNDNGRSALDKFRFRIFERNLEVEEQRELSQLPEDQYKVHIISRDWLQCWGHWLHGGVPPTAIDQNILVDKNGKLRVPEKSLDGWSLGFIGPRLWNHLKGAWGVNGPELTEDDAQGEEYEEIRMRLRLWKQSLKNLAVSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIY0</accession>
    <name>A0A8H7PIY0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein AF-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">YAF9</name>
        <name evidence="6" type="ORF">INT43_005899</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for an H2A variant leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">The coiled-coil domain is required for assembly into the NuA4 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YAF9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIY0"/>
    <dbReference type="OrthoDB" id="1741717at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23195">
        <property type="entry name" value="YEATS DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="5">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="129"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2174837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="335" mass="37909" checksum="2B0E1F6A1FF2261F" modified="2022-01-19" version="1">MKVEKKVKISASNTAIKTKKKPAPTDPAWRKWKVEIRSEDGQPLSNIIDHIEYILHESFENPRIVRAKEPYMLQEKGWGAFDLRIIFHFIDNLVAPQLVWFDLNFAQEAYFIVETLTFENPPDEFLELLNIPTNGSNQTPSKEAASSPTVKRKRRDSSDNESSVVSSEDRKRRSSSSSIIDWDMAITSPLSGGESSGADEYQPKKTMATQAAGKTTKKLPKTTTKKPIVEIPSHVEDDVYTAQDAANLHNVHRMADVLPEIRKEWGVPENVDMCELARALTMLDTQELQKCYSILQKRHPLENHVKGDEVVFDLYSIGADTIAKLWTLTSGRVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJ18</accession>
    <name>A0A8H7PJ18_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Arabinogalactan endo-beta-1,4-galactanase</fullName>
            <ecNumber evidence="3 6">3.2.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_005935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>The enzyme specifically hydrolyzes (1-&gt;4)-beta-D-galactosidic linkages in type I arabinogalactans.</text>
            <dbReference type="EC" id="3.2.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.89" evidence="3 6"/>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJ18"/>
    <dbReference type="OrthoDB" id="110914at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031218">
        <property type="term" value="F:arabinogalactan endo-1,4-beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011683">
        <property type="entry name" value="Glyco_hydro_53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983">
        <property type="entry name" value="ARABINOGALACTAN ENDO-BETA-1,4-GALACTANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983:SF1">
        <property type="entry name" value="ARABINOGALACTAN ENDO-BETA-1,4-GALACTANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07745">
        <property type="entry name" value="Glyco_hydro_53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034404782" description="Arabinogalactan endo-beta-1,4-galactanase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2174873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="339" mass="36771" checksum="7D46FE7E48D53995" modified="2022-01-19" version="1">MFGLPKAIVATQLLACLLSKVTATLYLGHDISSLPMLEATGQKYYLSGTQKKFDAIIQSTGANYIRSRIWVNPSNGDYNLAYNLALAKRAKALGLKFYLDFHYSAIPAGWPTDIDNLSWEVYNYTKSVVTSFVSQGTPVDMVAIGNEITNGLLWPTGNTSSWSNIAHILHSAAWGVKDASTTQPLIVVHTDNGWNQATQSWFYSNLMAQGIFLSTDFDVMGFSFYPFYGTDATLANLKATLEYMISTYGKDVIIAETDFPNSCSGVTLSESSIPISAAGQTQWVDDITSLLEALPNSHGKGVFYWEPGWVGNAGLGSACTSALLVDSSGNTLSSINMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJ52</accession>
    <name>A0A8H7PJ52_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LAG1-DNAbind-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_005758</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Su(H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJ52"/>
    <dbReference type="OrthoDB" id="2349896at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1450:FF:000003">
        <property type="entry name" value="Related to J kappa-recombination signal binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1450">
        <property type="entry name" value="LAG1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015350">
        <property type="entry name" value="Beta-trefoil_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036358">
        <property type="entry name" value="BTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040159">
        <property type="entry name" value="CLS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015351">
        <property type="entry name" value="RBP-J/Cbf11/Cbf12_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037095">
        <property type="entry name" value="RBP-J/Cbf11_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038007">
        <property type="entry name" value="RBP-Jkappa_IPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10665">
        <property type="entry name" value="RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09270">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09271">
        <property type="entry name" value="LAG1-DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20144">
        <property type="entry name" value="TIG_SUH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01268">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01267">
        <property type="entry name" value="LAG1_DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110217">
        <property type="entry name" value="DNA-binding protein LAG-1 (CSL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RBP-J/Cbf11/Cbf12 DNA binding" evidence="8">
        <location>
            <begin position="461"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-trefoil DNA-binding" evidence="9">
        <location>
            <begin position="640"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="218"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="292"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="546"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="721"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="792"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="970"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="326"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="721"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="974"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2174700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1245" mass="137027" checksum="542AD5FCB1C6D82A" modified="2022-01-19" version="1">MSSSGPSPYPVTDQEGLSRKRKQQQNEFVSHVDLQYNHHDTSNPSHFDNVFHQNDLQWQMMNPSMAQQDQQGFGMDPMFAFHTHNAQEMNFTPEHTQGFPTDPIRQHGPPHDPSFQNLPPHPDSSHPTDANAFASNMFHLSPSHHLRRHSVAVGEVMHHQPEQVSPYMDMNNPDMNFDRFRSRHMSTQGIPYDMSQSYMPYQPQSSLFIDTDHPQTLPTPPHTANPIQRRQSKSATTMTKSNARNTQRNRAMSLRLDTSAFDSPMHSGSMQQSSPLTPAFFSPAFLEALNADTQSNPDEGDVYPFPVHPGNQSESGPDAQFVDPSKTMNSARTNSENTSSNFYSSNVDQANTNTASDMNPSPSSSFIMEQKPFLAQQHTTPTIMEENEELFRHLADYGTNMHMPAAQMPINGLGIRHQNDHYAMQEAQIMYKSPSGGATDMRSAIGNFLSSASSLAAGEYTMMLLTSKVAQKSYGTEKRFLCPPPTTIILGPHWWTVGQDDSETKSTHTLHPPKLAIHMSGDATAMNNAQPVQLNTFEWSTATGERIDAPSNDRSTTNGHKASSSSSNAMVTATREPILSGRCVSKNLYINDADEKRKRVEVMVKVHLANGCDLGTFASKGIKVISKPSKKRQNAKNMDLCIHHGSTISLFNRIRSQTVSTKYLGVSTSNDSAIRYGGNVPLDWPGPGAPNDQQNANDSTCFSVRTSSWDPFVIWIVDTSGKQNEQDNQGSENSSGASPRRPTPPIIAMRVTPDDPVAIHYNQPVVLQCLHTGLVSPVMIIRKVDKGSSVLGGARMDRNTQQSDSLKTGGEYGDEALGDPVSQLHKVAFQIVNDPSTTLGHHSNFSSQQTFNEADYLPRLTEPITYLNCANDVVGMHHVNEPRKLNPDLKAELTNRANASRMSMDNEPVQEEWDWSALNNEAFYANPGLMNPADSAIVAHEGGRVVRKRRVSCDMSSNEMPMYRGVDQQQMFAGPGTPQGSTSSPSPVANALATAASSRRRVNSLNDVTLSNESQPRSIKKEIAQARRGSVTNQANSGAGDRAFWTEDVSDAAIWTIVGTDSVMYSFWSPSEQIGNLFSGFNSSSAPVTPVPIVSHYINDSIGGDNNLIIKSNHSSVSPSPMLTSEDSTPIMTSASPLKRSLTIYGQNFVRDLTVWFGNVPSPNTEFKTSEILGCALPDPSIWFNNDGDTFVVQQETLKVPILLVRGDGVVYRTRQWLDLGSTVKIQNMHQGSNAGDPSRTNVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJY6</accession>
    <name>A0A8H7PJY6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA-directed RNA polymerase II subunit RPB7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_001161</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJY6"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="7">
        <location>
            <begin position="9"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="79"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2175514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="19977" checksum="2E356A098A7C216D" modified="2022-01-19" version="1">MLQSNKDLSHTISLHPSYFGPNMQTQLNDKLYADVEGTCSGRFGYIITVVRVHTIGKGKILPGSGLAEFKVKYQAIVFKPFKGEVVDAVVTTVNKVGFNIILMMGFFADVGPLQVFVSSHLIPSDMKFDPNGNPPCYQSEDQIIQKDIHVRLKIVGTRIDATEIFAIGTIKEDYLGVITPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PK11</accession>
    <name>A0A8H7PK11_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PK11"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="179" mass="19600" checksum="39ABC1CFC1E8E718" modified="2022-01-19" version="1">MTDEAIESNSVEFGTRFVTVDGKQIKLQIWDTAGQESFRSITRSYYRGAAGALLVFDITRRETFDHLVTWLEDVRKHANPNTSIMVLGNKNDLDSKRQVSREEAERFAKENDLFYLETSAKAANNVEEAFVKTTEDIYHKIKAGIFDVSNQSNGVKLGPLQGGSSLPAAGSAGGGGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PK61</accession>
    <name>A0A8H7PK61_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aromatic amino acid beta-eliminating lyase/threonine aldolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_001281</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PK61"/>
    <dbReference type="OrthoDB" id="10261951at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000030">
        <property type="entry name" value="Low-specificity L-threonine aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="6">
        <location>
            <begin position="30"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2175634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="389" mass="42809" checksum="1B577482FCBEF753" modified="2022-01-19" version="1">MVVARQLLLRRFSYYTRPTMGYLKEKIIYDMTSDTATKPTDQMFEIMKQATRGDDVYHEDESVKALERYVSDLTGHEDALFCASGTMTNQLCLRAHLLQPPHSVLLDARSHVFIHECGGLAYHSQANVTPVHAQNGIYMTAAEVAINIAGEDVHQSPTRVVSIENTLNGLIMPRDEIEKISVLARSRGIKMHVDGARLWNASEESGVSLREYGKLFDSMSLCLSKGIGAPIGSILVGSKPFVAKCRHLRKLMGGGWRQAGSLAAVAHWCIENIMPTMKHTHQQAKRLAMSLEALGCVLVYPCMTNQVWLNTAPTGVTTGQLAEELAKYGIKIPGGNGVTCRMVLHHQISDEAIDQFITVAQNLFEQYKGSKPLAITGPASILAYPTTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKH2</accession>
    <name>A0A8H7PKH2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKH2"/>
    <dbReference type="OrthoDB" id="2555519at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38701">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38701:SF1">
        <property type="entry name" value="UP-REGULATED DURING SEPTATION PROTEIN 1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="510" mass="56058" checksum="E383CF9FE6F4139E" modified="2022-01-19" version="1">MAKESSKPKAINIVRPTPSINAAPKFQVFSPLRNNVKPPSDNYKPKVKTTAQISLSDRPGLALFAPSQKSKLEPHSDAHVRQSVSPPKRIPPVIHSTTSLHSGLSSSYQPKSHYVSRTSGTASSQISNQSANSRPSSVVSVKSDASVGLASIHADAPRRLSSGHPQIFNSTMARRPPGIVIPSNDIQNDAHNELEECIKNVHIMNRQPDNVTTRHPYDTTTANTEKDSELTLGHIFKKLQDEHTHSEDREDDSSDSSNISDTLHENQDTDEVAIDDDDGSPVNEARVNRKIADLEISNQSLLAVNAMLESTVRKQAAQIASLKRSSRSTDINELPKSNQEDIEIDTLITDEDDDEQFQRINTIIDRLIEEAQASIECKISHGGRVLSHYDESEEEHSVASNSTLALSSIDGDQTMVKDLHPKSPLTTRSHHRRRSSLARQNAHSLNEGPTPTTTDVRSSKSTAIIPITPRSPSMPARKVASAESLASSHSQHLNNRRSKPRVSRQGRVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKK1</accession>
    <name>A0A8H7PKK1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKK1"/>
    <dbReference type="OrthoDB" id="2217043at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="121" mass="13338" checksum="4F17DBE414F6EA79" modified="2022-01-19" version="1">MAFDEASTPVSSPNSTASSNQQDQLDSRDTTSIGTHDSDDNSIVCECGRRLGPGWTCPTCRRNCSICQRALIADESSYCDRCYSECEIHGLYRNTNFPDETPCPQCRDSSTTPQPRSTESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMI0</accession>
    <name>A0A8H7PMI0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_005695</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMI0"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032161">
        <property type="term" value="C:cleavage apparatus septin structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031105">
        <property type="term" value="C:septin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000162">
        <property type="entry name" value="septin-7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="8">
        <location>
            <begin position="51"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="367"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2176455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="434" mass="50279" checksum="2C5AAFEFE1AB273D" modified="2022-01-19" version="1">MNLLFFPLVHPFPPFSFQLLECQFVMAPAPIASGVGIANLPNQRHKIVAKLGSNFTIMVCGESGLGKTTFINTLFTTSIKDHKNPVRRHQKQLDKTVEIEITKAGMYLAKASRSDLLKHVLNTKFHFPHTELEEKMFKVNLTVIDTPGFGDYINNKDSWLPVIEFLDDQHESYMRQEQQPARRKINDLRVHVCLYFIRPTGHTLTPLDIEVMKRLGTRVNLIPVIAKADTLTPRDLANFKRKIRDVIAAQNIQVYSCPLESEDEATTARNMTIMNAMPFSVIGSTQDVMTPDGRQVKGREYSWGVAEVENEDHCDFKKLRSLLIRTHMLDLVSTTEDIHYESYRRGQMETRKFGDPKTKKFTNPKFKEEEDNLRKKFTEQVKQEENRFRQWEQQLIAERDRLNKDLEDKHAQIKSLEGELDALYQAQGRNTTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPG9</accession>
    <name>A0A8H7PPG9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPG9"/>
    <dbReference type="OrthoDB" id="5358398at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048273">
        <property type="entry name" value="Luciferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040841">
        <property type="entry name" value="Luciferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17648">
        <property type="entry name" value="Luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase" evidence="1">
        <location>
            <begin position="168"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="258" mass="28613" checksum="1E88C4530A412B71" modified="2022-01-19" version="1">MLAFFRRRPLLTAAAIIGVLGASIPAYRDYQLYMSYGAGGVPHNAFGWFMSRCLLTPFSQEMLGTEMYQKKINQGATMTNIEPDGRLPLRSGANPAMGPHVVPQRQISQLPDDEIKKQLNEAFYGFARKNSNLLKLAPSRLERHTDAIFLADTVFSSSPTPEAIRMQGEICHIHGSNDHSLHVVVSPRDAKEIVEAGWGQRHGFSGWEPAAKVTRGAIDLPAEYLFIYAPRNQEELEVIMELVKASVRFVSGGVEVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPQ1</accession>
    <name>A0A8H7PPQ1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="5">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_007946</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="5"/>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPQ1"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="6">
        <location>
            <begin position="38"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="7">
        <location>
            <begin position="200"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="104"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2177289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="311" mass="33095" checksum="CD22B5EE43AF341E" modified="2022-01-19" version="1">MFRFIKSTIPRPSSFMPATERILQIHNMVSPQKKSHSTVAFIGGGNMAEAIIGGMVSSGHPSSCITFSDLAEQRRDYMKSKYPDIESSADNLAVIAKADVVILAVKPQVLHTVVTGIADTLQANKPLVVSIVAGIAAADIDRWIGGSQSSIVRCMPNTPALVGEGAAGLYATEAVTNQQKDMAEKIVQAIAKEYSWVDSENLIDAVTAISGSGPAYFFLIMEAMENAGVEAGLSREDAKALTIQTCLGAAKTAQDSDDDLATLRRKVTSPKGTTEAAIKALEDGHIRDVMGNAVKAAFRRSHELAELFGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPT9</accession>
    <name>A0A8H7PPT9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPT9"/>
    <dbReference type="OrthoDB" id="2351940at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2178047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="187" mass="21417" checksum="CCD1763CB7721016" modified="2022-01-19" version="1">MSTPNSQTSSDYPMLSQRSLDNSRLGRHPLRNRYSNYPPYRILTHHITLSPGTNRLSSSPVGDNNPLEENPNPCIMDDSNEVSYSNLDRRQLATERFDNFTKEDFISHSAVLRNQKTDNIQDSDTEPVAWFQVKRDNQQCVDLAERSGRYVLLKLLRSEHTAENIDLQYVGLMGYYGPRSFAIGTLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQ27</accession>
    <name>A0A8H7PQ27_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQ27"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009141">
        <property type="term" value="P:nucleoside triphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="110"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="903" mass="102939" checksum="81E787966A4B34A3" modified="2022-01-19" version="1">MVDSLEYPLKGVKKNVRIIFIIEALAEGPYAKRKNYGKIEKPVWFTEKHSTWGEEKFISSYYIGDYLSTTDKLSLCVKFEVLQSKADLSLTRTTSNLLLSEKFYNNTTLSDISFRTVLDHNEQTFPAHKIIMAGASSFFETMFTNGMQETYSSEILLKDTDPAVFSKVLYYCYSMKLTSSSLDEIEKIIIMADRFGIDNLMEEGFRELRKELSARSVWDTWALAANPNIIVAALQIDVGNFPKEEEVFEALIRWAKYESVDKVPYDFEAVFENLTLDSMGADLPRPDASSISTPTLQSHSESEKDKLDPIRIKKDDTNIIRRHSIGVPERRRNKRHSHELSSPDAEPSPSIREILLPSMLQHIRFPVMSIDYLSTKVAKNEFVMSMEEMKDLYKQLSNSQYWTEMAEVSNASGSENGREPQENTGLLANEQQPQSHASYSAVNQEEDQSGQEQQQRPVYRKVTLIIIAVVLSTTVLATAFLASSYSPLRKRGYRADKIYNNGTHDFKQTFIMISLDGTVNDNLDRGITPNLEAIASQGVRAQYMNPSFPSVTFPNHWSLVTGLYPETHGVVGNVFYDSAMNKTFNYKSPKQSWDSEWWGGEPIWITSELQNITSAVSMWPGCSAKLKGKRPTYQVPYSDYVSSLEKMDKVLEWLDLPAEERPQAINVYIPTVDQYGHQYGPYDGRTLRTLQDVDGTIGHLLKGLNDRHLSDIVHIIVVSDHGMSESDNSRLIYYDDILDEAALGNIWKIEDWPLLGIRPYPGREDTINGIYEQLYRGSLLPDAKYEVYLRSDMPAKFHFSSNIERIPPLIAIPREGWNFVTHKQFSDPSKVYQPRGVHGYDNFNRHSRAIFVAKGPLFDWDFERGQRLKPFINVEVYSILNRILGLKPATNNGTLSGKLLAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQ56</accession>
    <name>A0A8H7PQ56_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQ56"/>
    <dbReference type="OrthoDB" id="2365950at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2178128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="411" mass="46778" checksum="469FFD80C31D52EE" modified="2022-01-19" version="1">MPSVQVQTVISKEETMYSTDRNSTGYSDISTLCQAKDFLPLTDEDKASQRYWIQYIPRKHPTTGVDVETTCAGQNRLKYRGMFTYTVCAAAVLAAVMFCFTHFRDQVYAPVPQMIQIYYSLLSFASLLVAVCIGGPLSVSLEKWRGILPSFIGRMDLLFVLSCGQWTVIRNVCTSNQNYFWPLLSNVLQALISQIFILAFAGGDVFNSYVALITSIATWYSLIPILIGMAFSATYLHSIPDRICFYPAEYDKVRPFVLAGKPGCYIVGANRSGCIHRMKEARCVRSDRWRDLEQNNFSYQFEIPLAGWQAASIKEGFSYDRNTQVYMLTNGTQEDVQRTMQWAVSTNENIYMQSYVECGLCACNMAQLLRCNIVVVQRSGWRASEMRSTKKTAVKRTLEHLFTPWKRCGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQD9</accession>
    <name>A0A8H7PQD9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQD9"/>
    <dbReference type="OrthoDB" id="2382382at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="150" mass="17282" checksum="EB096D80259162C0" modified="2022-01-19" version="1">MLHISLPHKADKKDKRKSFPFGNRKPALRSRCRSTLSGCSEESDSRISNRLSRLFGTHSQKSFSDSSTSSRSSTSEETYRTHHGHKKRLIHTEDSVPPHMIPPYSPTGAWNGKFPYSNFYVRLPDGKWMIRYRTGDRDILGTDVFESYMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQL4</accession>
    <name>A0A8H7PQL4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mediator complex subunit 20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MED20</name>
        <name evidence="5" type="ORF">INT43_003228</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the Mediator complex subunit 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQL4"/>
    <dbReference type="OrthoDB" id="1854899at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013921">
        <property type="entry name" value="Mediator_Med20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12465:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12465">
        <property type="entry name" value="UBIQUITIN SPECIFIC PROTEASE HOMOLOG 49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08612">
        <property type="entry name" value="Med20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2177975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="199" mass="22663" checksum="197A5BBBF0B71802" modified="2022-01-19" version="1" fragment="single">CLCSSIVRWKNATGMRDFTTIDEHVVKTLHGKNTGRWGLTCKVYRDNSRNNSGKLLYQISLAQQPRQLYCMVDGGVVVEVERDIETIFSRLKNLWVVRQSATIEGTSYDIGDFTLRVANILLGSTYKGLLLEVEYRPCSSPYGATDIIRDFVESLIPANAQISIDTEYDYEKVGLSNQEFTIAHTGYQYMHLFRKDSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQQ7</accession>
    <name>A0A8H7PQQ7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_003418</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQQ7"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000021">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="118"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="329"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2178165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="541" mass="60047" checksum="D317AD743D03BCC3" modified="2022-01-19" version="1">MDSKSQSHRLGQFKNKSTFKTDEVRRRREAQSVEIRKQKREDNLAKRRNLNAVSNQDMSESEDEMEQAADLQLREILPPMIAGVYSNNIEQQLDATTKFRKLLSKERNPPIEEVIACGVVPKFVEFLRSPHSLIQFEAAWALTNIASGSSQQTQIVIEAGAVPIFVELLSNQVPDVREQAVWALGNIAGDSPMCRDFVLSCNILPPLLSLLNEHNKISMHRNATWTLSNLCRGKNPQPDWSMISPALPVLSKLIYSNDDEVLIDACWAISYLSDGPNEKIQAVVESGVCRRLVELLMHTSTSVQTPALRSVGNIVTGDDIQTQIIINCGVLPSLLSLLSSPKEGIRKEACWTISNITAGNAAQIQSVIDANIIPPLIHTLATADFKTKKEACWAISNATSGGLNKPEQIKYLVSQGCIRPLCELLTCMDNKIIQVALDGLENILKVGEMERSNDMDGVNRYAIFIEECNGMEAIHSLQNHDNEELYKKAYQIIDKYFVADDDVEDTELAPKVDQDSGAFAFQENVNMPTGGFQFGAFGAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQU3</accession>
    <name>A0A8H7PQU3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQU3"/>
    <dbReference type="OrthoDB" id="2355621at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="107" mass="11759" checksum="ABF0E7B95F7C1243" modified="2022-01-19" version="1">MHLFSHHKKHPATNTAQPDGSNNADGQHDVSKQDPEVVAPTPKKDHKHHHQHSNDSPNRTDSPQAMAKYLADNMRSSPHPDHVGDYVDPMGGSINQTTERDPMSTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQV5</accession>
    <name>A0A8H7PQV5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein Zds1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQV5"/>
    <dbReference type="OrthoDB" id="5589766at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040206">
        <property type="entry name" value="Zds1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013941">
        <property type="entry name" value="ZDS1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089:SF1">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08632">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01327">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein Zds1 C-terminal" evidence="2">
        <location>
            <begin position="485"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="743" mass="81997" checksum="8168A76337DED62A" modified="2022-01-19" version="1">MGSVNTHTPSLDLSNPQKEDIGPSPPPTPTGGLARNLSVTSLRRTNSTEKKEQIREVINIETPDPSHLYWVPAEQHPEIAPAEFNNWLQHHAYNSERRPRIRRRRSVLSVSYTPEDIEADEEPIPEPVNETESGVEAALASLERGSRHITSPPQSLEPNREPDPARKDRIRRSVSLSLPIISEQSDHINVFDRNSSPYDESRVLVPRADSSLLRRGARTKIRRNSTMDSSSGSSNESDLSHRHSRNSNIASYHNADSQANRTGTVPPGGISLQDTPVVVVEEVGKTPSSQSTFPPPKDKKNRVAGPRTSSLPSAAARDILAAKLEADEMQNTSITTNSSIPSNIPAVTTDTHVLPPPPPTAQPQPPQPIIPTDKLAPKSLSPTRSVSTGRKSTWSRLFRTDDSNKPKKNRESAPVAEPTKMEEPESLETIVSPPTTPAQSPSANDSIVAARKFGSLSSLFSRASVRPVSQKSESIMASPKSNKVIIKKAIPLPKRLPIHVERAVYRLSHMKLANPRRPLQHQVLISNFMFWYLSIVDGASNNSGGSEPVTEAQAQAQPTGQDKKGKKINKLVAAGKKRRQEIIQNKQRKAQMAHERMGGRRSETVIPSVQYDRQVRHQLPHVGPRGPLMTPQHYLSTAGAPTGFVVPQQYLHPKNSSTGGTGSEDDDDEELEDEEDEEEDEEEDEEEDEVQWPLPPHGPQESLQKPSLELNHAGLGAFSSDLIDMIKFDEEDDVPLAMYRKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PR61</accession>
    <name>A0A8H7PR61_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PR61"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF4">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="57"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="546" mass="60843" checksum="7F52CE755DB5DB8F" modified="2022-01-19" version="1" fragment="single">IQSWDINVNDINIIPSHGIVTLFRFLKHCEFIVPTALALMLATIQWRLKENVDSIRFDSLPKELLESGLVFFRNYDKLNRPIAFVRLRQFPKFSQGSLLDNIKPLLIYVLETARKLTRDLTKQREQENTPQPLSSQIAVIIDIKSAPFLPLDAELPGALMDIMDNRYPGFVGSVYVLNYGWMYSGIWQMVKLLLSEDAKSRISFPSAAEVQKVIDPTDLLIDLGGLDDYEWSRESDLALQKYGTKSTLEELSSKHISPTEQLPSPIPSPPMISRSNSNASMLSSDIWFDATSEQRPRSSSLISTNSVYMSPRSMSIASSGYGTPTIGSPYLLPIARRAYDSIPPAITPSAVSRPYTGLHTGLAFLTSLFTRANSNTQNQNQITPISAHILSDRLHTLQDDQLLQFEMLPEAHHASQNQPPSHIIIRTARFPNLLSPSHPQSPYVTHPITSQLIRAERRITRTARRMFRMTFKFNGAFYWMVLYLLLRGGLEDVVKVTTETLVQVVVGGNSASAGIGSHVNMRRGVIWGSAGAAVAGLIGLTLGSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PR69</accession>
    <name>A0A8H7PR69_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_001658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PR69"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2178812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="104" mass="11815" checksum="038A6669EA02AACD" modified="2022-01-19" version="1">MVADRPLYLKMQLVIVTVMDTNSLWLHKGSLVTPNTIKETFKRLAMTYGHVNMTFGHYRHVNSTFLGESFTKKGIEVGQDEIYGQAGHTSHTAARVYETTTEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRS8</accession>
    <name>A0A8H7PRS8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_001947</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRS8"/>
    <dbReference type="OrthoDB" id="1106148at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055304">
        <property type="entry name" value="CHCHD2/10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523:SF2">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="3">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2179097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="176" mass="18786" checksum="453D2B2F56BA690E" modified="2022-01-19" version="1">MPRQQRRSAPRAPAQQTRQAHTAPSRQAPPPPQQRGPPPQQHQQQRAMTQPPSAAVGQPAPASQGPGLFGQMASTAAGVAVGHSIGHAMTSGASAMFGGGSSEQPAEQPQAAPQQQYSDYQQYQQPSYQQQSVGAATCEGDAKAFTKCLEVNNNDVVQCQWYLENLKACQQMSAQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PS31</accession>
    <name>A0A8H7PS31_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF1014-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_001586</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC124 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PS31"/>
    <dbReference type="OrthoDB" id="76412at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010422">
        <property type="entry name" value="Ccdc124/Oxs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054414">
        <property type="entry name" value="Ccdc124/Oxs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054413">
        <property type="entry name" value="LSO1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06244">
        <property type="entry name" value="Ccdc124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22048">
        <property type="entry name" value="LSO1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LSO1/LSO2" evidence="5">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Coiled-coil" evidence="4">
        <location>
            <begin position="115"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2178740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="24922" checksum="5C91E2DAC7D2E486" modified="2022-01-19" version="1">MPKKQGGVNTKVAAANERKAAAQADKDKKKAQVSEEHEAAEWSSGSKGKSKKDQDAEKKAAVAAKKAEAAKQLAEEEKELAKTKPAKPLKGEEKKAAKKSSAVNKDSQARRVIPEFSASNLDDALDLLAIDGPGAGAVGGAKNKEVEKHPERRFKAALAAYTEREMPRIKAENPGLRKTQMEQIIYKDFQKSPENPFNQANILSYNATQDDVAESKSQRRKVVEDRLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PS71</accession>
    <name>A0A8H7PS71_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Male-enhanced antigen 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PS71"/>
    <dbReference type="OrthoDB" id="5593200at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06910">
        <property type="entry name" value="MEA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2178800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17854" checksum="5FD33199EDCD8826" modified="2022-01-19" version="1">MQELEPASRHDADPIHSDSSLSDMDGPQMGSRDEVEDFARKLDQLVINQQHDEDDDEDEDEDEDFDNDAFGYQQLPQDTDGPETDSGHNENGSTFTHETDQPSRTEPVQYQAGEDNNIPEDQVEFIKNVMSKIQLPAPDWAKRLPEERWLPRRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTC2</accession>
    <name>A0A8H7PTC2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTC2"/>
    <dbReference type="OrthoDB" id="2287593at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034409585" evidence="2">
        <location>
            <begin position="21"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2179823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="362" mass="40534" checksum="94C33ABB767E67E9" modified="2022-01-19" version="1">MRILLLALLSTQLFVGLVQSRPLYSLALLSLGSLEQEPVLLPDFASSIFNANRQKVIALEKSIEESEKLSDTSSPSLSITDVNDSTALSRSDATSDTTSDNDISTTTLEPEPTMAQAESDFEVDLSRFSQLLSVHLLFDHFENAVTNLAEKVSRRFQETIQFSILNGNGDSDIIPEDDAKNEMVFDIQVLKGQIRGAVGSFIEDNLPNVWYQHATSLDKASLQQKLRQITMSLCEDSTSHPDTVAYSCIVEHSTQLQSQMDRFVGKNLDRTLAFVTKRELPRLFEATASEVHSVLLYFNRHVLHSSDKRLQIQLARQAEDTEEEWIRKEVSQVFEAAAHWEHAADEDENANSVAKFAQLAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PU26</accession>
    <name>A0A8H7PU26_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PU26"/>
    <dbReference type="OrthoDB" id="2287482at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="395" mass="44349" checksum="F201C9DAF2E7850C" modified="2022-01-19" version="1">MPIPIPSASHAQQQLAWSPTYSLSSSTSSSSFYPDFVRELASKAPTPYGTIPPRRRKKRRKSSISEESSSPGQSQDASPDEPSILRIQRRMSHVEDWVKVDSKESLPDDDELSPSSSLLSQLFSSSASQVPYVLPLHVPPPNLSNPSEPSLFSNNSSVLLQNTSQSPDLVYSQVGNETYIDYIWQSAVDSNPGIIPSETVDLSSEDEDIEDMCIDCTENQDVASVLPWSGEQTKAKPVLSLATVTAKRSMIPTRNTSIGWTNKLRQSLNTLHHYYTPNNNRSHSILESFSHRYKATAPAKRMALPQAPKPSKLARRSEANTKPRIDLQNNIIRRDIRANPDHLRIIVAELNMMRSRKVLYPLKPRNFLPRRKDIFVRSESSSKLRYMDTFSSIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PU38</accession>
    <name>A0A8H7PU38_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isovaleryl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.3.8.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">INT43_003664</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>3-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 3-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:12276"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57345"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.4" evidence="5"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PU38"/>
    <dbReference type="OrthoDB" id="9988775at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01156">
        <property type="entry name" value="IVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000007">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000003">
        <property type="entry name" value="isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000004">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034183">
        <property type="entry name" value="IVD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15 16" id="KW-0274">FAD</keyword>
    <keyword evidence="7 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="19">
        <location>
            <begin position="41"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="18">
        <location>
            <begin position="156"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="17">
        <location>
            <begin position="263"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="190"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="274"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="370"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="397"/>
            <end position="398"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="399"/>
            <end position="401"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG2179878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="416" mass="45299" checksum="B5D8F84188926F8A" modified="2022-01-19" version="1">MLSSIISRSIKQSSQAWVRPALHQRTLVSAAYNAAVAGLSNEQMELREAVHDFAQNELAPRAEQIDKENAFPMDMWKKFGDMGLLGVTAPEKYGGLNLGYTEHTFVMEEISRASGSVALSYGAHSNLCVNQIVRNGNEEQKQKYLPKLISGDHVGALAMSEPGSGSDVTSMKLRAEKKGDKYILNGNKFWITNGPDADVLVVYAKTDLQAGARGITAFLVEKGFKGFSTAQKLDKLGMRGSNTCELIFEDCEVPAENVLGAVGKGVYVLMSGLDLERLVLSGGPLGLMQAALDITIPYVHDRKQFGQPIGEFQLVQGKLADMYTKLNASRAYVYAVARACDNGQVSNKDCAGVILYSAERATEVALDAIQCLGGNGYINDFPTGRILRDAKLYEIGAGTSEIRRMLIGREFNKLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PU58</accession>
    <name>A0A8H7PU58_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PU58"/>
    <dbReference type="OrthoDB" id="2126185at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021362">
        <property type="entry name" value="DUF2834"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11196">
        <property type="entry name" value="DUF2834"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="347" mass="38724" checksum="842091A3C6789DD4" modified="2022-01-19" version="1">MITYPVDIAILAGYFALIFGLLGCILPFVAKSWVWSKTSQFTFGFSLVALLTTWTYMFKYFHYSYLQWQSSTDARPESLLDSLSLWLHSVSLFDDAWRTVSVGTIQWLWSHQLCAFTSTVWMPFLAIEAQRRKIPYAWAYMLLGQVVAISFAACLFFAVMACLPIRPAGTVAFNASITAICAVVGIVTVVVSPFVATGSGFMPNLMLMHAVLVVPLLLPNNWLHPFTVRQSRALAAIYLFSAGANFVNLLQQLIPAIVTAKAQFIPEMISVFMGHPAQSSIGCDILCVNYFCAAWMILDSQSLDRPKQGLHTKMNRKIAYFLCAATPVLSISITLPLYLAWRELSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUV6</accession>
    <name>A0A8H7PUV6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ceramide very long chain fatty acid hydroxylase</fullName>
            <ecNumber evidence="16">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">INT43_003969</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16 17">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="16"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUV6"/>
    <dbReference type="OrthoDB" id="2204368at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15 16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4 18" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16 18" id="KW-0408">Iron</keyword>
    <keyword evidence="3 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 16 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 17" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="20">
        <location>
            <begin position="4"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="18">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="18">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR005149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG2180180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="351" mass="40675" checksum="F8C382A85B4377FE" modified="2022-01-19" version="1">MTAIKQFTQAQVAKHNSLKSCWIIHNNKVYDVTEFAPDHPGGDDLILDYAGSSVTDIMKDELQHSHSDSAYEMLEEYLVGVLVDKVSEEDKKGEIHIEETDHFFEDNFKPKQTDLSADAKRSQFLDLRKPLFPQMLQANFSKEFYLQQVHQPRYVPYSAPLFGNFLDAFTKTAWYIIPTIWLPIVGYQVYRSLESNLPVVTSCCFVLGIFIWTLVEYILHRFLFHLDDWLPDHPLALLLHFTLHGIHHYLPMDKLRLVMPPALGFALAYPLMCLAHILFPAVAAYAIVGGAVLGYIGYDCTHYYLHHAKVLEFHFKEMKKYHLAHHYKNYESGYGITSKIWDYVFGTKLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVA8</accession>
    <name>A0A8H7PVA8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_008468</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVA8"/>
    <dbReference type="OrthoDB" id="434258at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="58"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="4">
        <location>
            <begin position="200"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2180888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="376" mass="41762" checksum="22688C28A2EE2783" modified="2022-01-19" version="1" fragment="single">GGAKTELVDFKGQSAIDGMDGGDDMIGASATPSPPGTPTSRHSQSNTPVQNADDIIPTAIVIKNIPFSVKKDVLITIMNSMDLPQPHAFNYHFDNGIFRGLAFANYRNREETDLVIQALNGLDLGGRKLRVEYKKMLPGQERDIYLSDDVRDSLSPSSSSRLSSKKDGMNEKRDSRNSPRLKPGSDQEPQPEDGPLDLNHPDTLLFYDQLFQFRSDPSRDIFIYPKTTSSKQRRIIHYLADRLGLYHYSDGDGSERQIHIVKKPANAAQLRGDGVGRRTSQRGTRNRLRQSQSQDRVRDSDNGSPPRRDNFRRSFVSSSPLSDSSGTNTPNVMYPIRQPAGPVPEKNFASRSASMTRKMSQLNLDAPAFEPAGLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVS7</accession>
    <name>A0A8H7PVS7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Prephenate dehydrogenase [NADP(+)]</fullName>
            <shortName evidence="9">PRDH</shortName>
            <ecNumber evidence="9">1.3.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_008725</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>prephenate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21640"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8 9">Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the prephenate/arogenate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.13" evidence="9"/>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVS7"/>
    <dbReference type="OrthoDB" id="5399569at2759"/>
    <dbReference type="UniPathway" id="UPA00122">
        <property type="reaction ID" value="UER00962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000004">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000339">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3660.10">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050812">
        <property type="entry name" value="Preph/Arog_dehydrog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012385">
        <property type="entry name" value="Prephenate_DH_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363:SF0">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036510">
        <property type="entry name" value="PDH_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="10">
        <location>
            <begin position="15"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2181143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="442" mass="50516" checksum="3E75B2E3500C9413" modified="2022-01-19" version="1">MSNSPTSIEKQKNEIELGIIGMGDMGRMYANRLSQHGWKRISVCDLPSNYERLQEEFKDTSINVLRDGYHVSRRADWIMYAVEAEHIDRVVAQYGPATKIGSIVSGQTSVKQPEIEAFERHLPNDVHIISCHSMHGPNVNPKGQPLVMIKHRASQEKFELVRNILSGFESNLVELSYQDHDRITADTQAVTHAAFLSMGAAWKANNQFPWLLPHFVGGIENVKVNVALRIYSNKWHVYAGLAIMNPSARIQITQYAKSVADLFKLMIQEKEEEFRSRIREAGNFVFGSLNDDHVPILLDDRLLDEFSLSNVPSGSIREPNSHLSLLAMVDCWYTLKLNPYEHMVCQTPLFRLWMGITEYLFRKPEMLEDAIQAALYRKEIRSDDMEFVTCARGWAECVDLGSMEGYRKRFESTAEFFKDRFADSAVLGNKMIAMISKNIQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXJ3</accession>
    <name>A0A8H7PXJ3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar-sorting protein SNF8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_007030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SNF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXJ3"/>
    <dbReference type="OrthoDB" id="283883at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000085">
        <property type="entry name" value="Vacuolar-sorting protein SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000397">
        <property type="entry name" value="Vacuolar-sorting protein SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017215">
        <property type="entry name" value="ESCRT2_Vps22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2182103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="251" mass="29040" checksum="081F40321A5C2893" modified="2022-01-19" version="1">MRRRAVGYASAHNRQAIDRKYQEIGDSIAAREIQQLHDQLDTFKDNLQDFARKYRKDIRRDPEFRMHFQHMCTKIGVDPLASNKGFWADLLGFGDFYFELSVQITEICIATRPQNGGLIEIEELKRRVKAKRGTSKDPKAQQQEISEDDIVRSIKTLKPLSSGFEIITIGKKRLVRSVPKELDTDQSSLLLLAQTNGYVDKSAIEKELRWHDGRVTRALDNLLQDGLAWIDCSEAEEDRYWIPSFYDFGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXT7</accession>
    <name>A0A8H7PXT7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_007165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXT7"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="315"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2182238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="394" mass="44156" checksum="7A337F5C875613A5" modified="2022-01-19" version="1">MVNIKPAADARQRIGTVIGQYELIDLLGLGAYGSVFLARHTLTQKLFAVKCLSKVGLSERQREFQLREISLHAQVACHPNIISMEQVIDTQDYLYIVLEHCREGDLFYTITEGRGYTDSHNDIRAVFLQIIDAVSYLHSQGIAHRDLKPENILTFEGGKKVKIADFGLATTEAISTAFGCGSTFYFSPECQGGLHKKLRAYSTKPNDVWSLGVILINLTCGRNPWKQAHVGDETFSAYLRNPDFLLSILPISSQLNTLLKQIFCVDPAKRIRIEELRAQFLACKYYTAQEEKSAAKEKSVKPVAIKSYASISPSNLSNVPQHAYESHDGDSYERDHLFPGSSESVSSSDSSLSWSSIQIDANQPDAIYTKERHCPGYFDTVISFDQNQQQRVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXX7</accession>
    <name>A0A8H7PXX7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ERCC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_007083</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EME1/MMS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXX7"/>
    <dbReference type="OrthoDB" id="343092at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033310">
        <property type="entry name" value="Mms4/EME1/EME2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077:SF5">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MMS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077">
        <property type="entry name" value="EME1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21292">
        <property type="entry name" value="EME1-MUS81_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="15">
        <location>
            <begin position="124"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2182156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="433" mass="49528" checksum="7B6BB20E91CB0626" modified="2022-01-19" version="1" fragment="single">SEGLPSPDELKRIFFPKNSKAQLRSPLRHSTQTEVIVLDDSPPIVEVKVKRKVDSVNYDNDGDDCSSRKLGDMERNKAIKTSAQKEAEKERLKQIKEANAIRLVSTDKLHDTILCLESSLHSSEVGQAIQDQFQEKEAEIRSVDHLVKNTIQWRRKCLADWDSSSQSYIPNEQGRIKVVQDKHIGVYFDMQRLVELISKNQLIPTMEQLKHQHKQCQIVMFIEGLQKYYRTRKNLQSKSFQSLVLRGIANTYNDDQRSTSTSKKPRNNKSDQSEWLANGPDRNTLEDIMTTLQFEYRVMIIQTVDCAATASWVASVTANIATGGRESNEILDFCMDGRIRSGADNTDTWLKMLQNIQQCTEAVAKAIVREYPTIYSLYEAYTRCKSTADAEMLLADIEVQRSVITQRDRYVNKAMSKKIYNIIMSGDSRLVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXZ2</accession>
    <name>A0A8H7PXZ2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_008783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXZ2"/>
    <dbReference type="OrthoDB" id="2378832at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034020597" evidence="3">
        <location>
            <begin position="30"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2181201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="511" mass="57234" checksum="5DEC90134DFE18BE" modified="2022-01-19" version="1">MFSSKKLLVILLLTLSALVLLTASKKVDTDDITTWDKAQLKAWLTEHKINYDSSSDLSSLVKQYRDSATHYAGLFGVKVDQATDKLRSSLSSKKEISDANIDYIVDEVKRQLRTLELEGQLDYQHIQGGLNKAKKDILKKKAATEEQWSNIATDVEADFLTTKKSWYQKFFSNKNNAADSAKAWLDETRSNLESQKDLSEKQINEIIDSMRTRIESVDDWRKETAKKDKEWFKQLTKDMETKAELTKEQAEQTIANIENDFAGFKASAIEYANGAYDSGQAYLSPFLERVSTSLRESGDLTQAKVNEIIAAIKARFGNVNWKTMQAQQQKTYLEQFRDDISEQSKQTKDQVNHIVGIVQTSLEEYLASIKSYLSPNANAASQASMSASSVYGAATSNVDAAQSSAASATSSAKSAAASATNEAQKNVQKWLRSNERSLFEKKGYAQAHIDWIENYLIDSFKNAKDITTQEVNDAASAVQSYLERATDVTKDQARSTAEQIRNGLQHARDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYL5</accession>
    <name>A0A8H7PYL5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3</fullName>
            <ecNumber evidence="7">2.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Protein phosphatase PP2A regulatory subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">INT43_007042</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="30">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets.</text>
    </comment>
    <comment type="function">
        <text evidence="22">Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the STT3 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="7"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYL5"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000001">
        <property type="entry name" value="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000189">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01025">
        <property type="entry name" value="PR55_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="20" id="KW-0464">Manganese</keyword>
    <keyword evidence="18 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17 27" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="565"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="595"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="625"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="661"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="692"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="722"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="784"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="810"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="834"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="910"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="28">
        <location>
            <begin position="442"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="29">
        <location>
            <begin position="973"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="859"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1155"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="867"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="26">
        <location>
            <begin position="1162"/>
            <end position="1184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00055525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00059243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00067298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00067960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="KAG2182115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1184" mass="134640" checksum="E06B89C8FBB1896F" modified="2022-01-19" version="1">MTAIEDHDWKFTQCFGDKSESGDVTDADIISAVEFDQTGDYLATGDKGGRVVLFERNESKTSCEYKFYTEFQSHEPEFDCLKSLEIEEKINKIKWCRRQNQAHFLLSTNDKTIKLWKVFEKQLKVVAEGNNEPTNNSYGLQLPKYTSQDTIVAAVPRKVYANAHTYHINSISVNSDDETYISADDLRINLWNFGISHQSFNIVDIKPANMEELTEVITAAEFHPQHCNLFMYSSSKGTIKLNDLRAASLCDQHSKLYQVPEDPSQKSFFSEIIASISDIKFSNDGRYILARDYLTLKIWDVNMDNKPVTTINVHEHLRNRLCDLYENDCIFDKFECTFSGDGQSVMTGSYDNDFHIYDVEGKTDITLQADKSAFRARRLNSSKRLSRKPARSDFGMDFIDYSKKIMHSTWHPHENTVAVAATNNLFIFAMAQLDTSNQQALLKTVILGLIAGAAFSSRLFSIVRYESVIHEFDPWFNYRTTQMLVKDGFYEFWNWFDPRAWYPLGRVVGGTVYPGLMVTSAIIHNVLHFLHFPVDIRNVCVLLAPLFSGATAYATYLLTCEIKDSSAGLLAAAFIGIAPGYISRSVAGSYDNEGIAIFLLMFTFYLWIKALKLGSALWAAGAAFFYFYMVAAWGGYVFIINLIPLHVLVLMVMGRFSSRVYVSYSTFYILGTLMSMQIPFVGFQPTRTSEHMAALGVFGLCQILAFVELVRSHVQERQFQTILRLVVVFTFVAGVGTLTLLTLSGYIAPWTGRFYSLWDTGYAKIHIPIIASVSEHQPTAWPSFFFDLEMLIFLFPAGVYLCFRQLRDEHIFIIVYSVFASYFAGVMVRLMLTLTPVVCIAAAVTVSTILDTYLDLSTSEDGSGAVTTPPTEPAAAATSEKKPKKSATKEQPTQAVKEPYYGILNFDSRAIVILNFVFFLMIFVWHCTWVTSNAYSSPSIVLASRNPDGSQHIIDDYREAYYWLRQNTKEDAKIMSWWDYGYQISGMADRPTLVDNNTWNNTHIATVGRAMASGEEDAYEIMKQHDVDYVLVIFGGLLGYSGDDINKYLWMIRIAEGVWPDKIKESDYFTATGDYRVDDKASAAMKNSLMYKMSYYRFTELFGPQQPVDRVRQQTLPKESPELDVLDEAFTSENWIVRIYKVKDLDNLGRSHKEVAQFEAGKKKRKAQRSSKSKARRKQREGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYW2</accession>
    <name>A0A8H7PYW2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_007355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mS38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYW2"/>
    <dbReference type="OrthoDB" id="2429891at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035">
        <property type="entry name" value="AURORA KINASE A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="6">
        <location>
            <begin position="190"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2182425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="223" mass="25532" checksum="F893BA555F8B9584" modified="2022-01-19" version="1">MLSSAIRLSRPLSQRVTTRSTSRITSTLIFRSYSSEHNDGSNPNSNNPEELKRQTSAPRLPFVPVINIPEQELAHTAFFALHRPLLGLANEDKPYFGHQPYGQQDDSEDVEDLSQFMANMRPFAAPEQAADEDETTFTITLNPSHPPQTNDIPPTPMHNLETHVMPGADQIVDYLELLQRKMKKEDEAMEATSVLRKRKLKMNKHKHKKLRKRTRALRKRIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZ50</accession>
    <name>A0A8H7PZ50_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_007300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZ50"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="62"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2182370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="559" mass="60519" checksum="71B7AD82FF3B120C" modified="2022-01-19" version="1">MALSDQDTAKQPILAAKNVKSYQAVNIEADDSHSDSSDSESLHESNEDIVAKRLNGAKRINVLLGLWTGVFLSALDTSIVAVVMSEIGSEFQRSNQVILIATAYLLSYTALQPLYGRISDIFGRKSAYLFAQAAFVIGSVLCGVAPNLEFLIVARIIAGIGGGGLNTMSSVITSDLVTLRERGIYQGYANTAFACGGTLGAPLGGWITERFGWRYCFYINLPICLIATYLTRPLQNYNLHVEGDGSYHIMDKLKKVDYAGAFSLVTAITCIILATSYGGNAVPWSHPLIIAAFVGFGAMLCIFILVESCWAKLPVLPMKLMVMRNPALCSLTNFFSMMASTAMVYFSPLFFVAIMGFSSSKAGFWVSARVVGVSLGSLSAGKYMSHYGRFKPYLVMTYFCLSIAMFGISTWTATTPAYIQIGAMLLDGFSAGGGLTTSLVAMLSSVEPEDIATIASISYLFRSTGSVIGVSLVSTVFQSKLKQYLEQSITGPDAERIIDLVRRETTAIHNLPDNVRGIVIDCFQKAIKLGYSLTVVFAFTAFIISIFVHGTKLHNRVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZ76</accession>
    <name>A0A8H7PZ76_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZ76"/>
    <dbReference type="OrthoDB" id="5563016at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2183434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="224" mass="26145" checksum="DA54C5701A2002DD" modified="2022-01-19" version="1">MPADPSHIAAYRIPFSVAVRKAFDLPRHKYSFVEEPNGKYFFTSSNVKEWWSAVKSTIHTPKKRKSRQVVPSEFSTRRTTALKPILKKASSFSNDYDIPHMSELYYASQLSMPKLKTMPVPWLHLYPAPMGYYSMDNFHIQDSMNYPEPAYQQGLKRQSSVVWNEEVEIIPALSSSKYNRKPLDNATYMNLNQETKSAIRDELNYYKMNEMVVHEMSMSHTVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZQ8</accession>
    <name>A0A8H7PZQ8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Translation machinery-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_006730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 4">Interacts with the 40S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">The SUI1 domain may be involved in RNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DENR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZQ8"/>
    <dbReference type="OrthoDB" id="277199at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005873">
        <property type="entry name" value="DENR_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01159">
        <property type="entry name" value="DRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="SUI1" evidence="5">
        <location>
            <begin position="107"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2183719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="195" mass="22308" checksum="BF0F7A32CB19E442" modified="2022-01-19" version="1" fragment="single">LYCDSFDMIAEKVLYCGVMFATVCSMPPEYCEFSGTQEKCKTWLQKNHPAEFSKIYDEAGIEKGVEGIKLEEKPAEEKKDRSQVKDKSAQLEAKLEKENQKKMQSHVIIKRVERTKRKCVTTIHGLEVFDVDLKKAAKMFANRFACGSSVAKNNQNQDEIVVQGDFSDELLDLILGNWPHIPEDNIDLVEDKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q028</accession>
    <name>A0A8H7Q028_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3020 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q028"/>
    <dbReference type="OrthoDB" id="5595797at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021386">
        <property type="entry name" value="SPP41_DUF3020"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11223">
        <property type="entry name" value="DUF3020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3020" evidence="2">
        <location>
            <begin position="110"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2183423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="372" mass="39639" checksum="C266B877D46A4B18" modified="2022-01-19" version="1">MTSLTKEEPQSSSDHAQQMEAVFGESYNFATGDHARDQAATQAELVAAAVAAAANNSNGANDNYHALVASAAPGGDNVIATATSQRPTDAVQAAELVKRELANQKVRAENRERKKRWREQNEDRNKDNDLRCRVNKRANRLFGMADSPNKRKWCQEEFSKRQRKRQEKERRKNTVNGSAPPGSDTGYQSPNAMASFTASQLEALQQQSSDYYPMSTNGIPPLSPTTATKLLNSNLAAVLKAGKNDPSATAAAAAAVLQSPQFLQLNQLLSQQSAEAAHYTSDMSTADGTNKSSDSILEQLTAAAAANAANSASSDQVNTETGEGTSGDAADKGESQADKPAENGKPANGQGGGDYPMDAVMTLMQLNAGWRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0B4</accession>
    <name>A0A8H7Q0B4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_006564</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0B4"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22147">
        <property type="entry name" value="F-box_SpPof1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="308"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="525"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="594"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="631"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="671"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="713"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="171"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="431"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="439"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2183558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="839" mass="93352" checksum="11F80C7D15559CE2" modified="2022-01-19" version="1">MAEQESFTDKRNARFFAKRKHLQQQLSSPLPSPSPTGNISTKVLGAFKSYSNIGSSSSLNSSSRSSSSNSSTQDHLKSLDVSQYPLAETLTPPAMKALCFDNDIAWDQSAMMESLHKTSLIGLLPAPDDDMKDENLSHCSRKRRASSLSLQAEALFPTDLEPLDINKRVRTKADVANDTERSNRTPHSLSEYDSDEEPAQELSIATTSMDQDSCDSPNSAFPSPSPSPIVATAEPHQSLTSYFDSAPLGRDLHTQNTLRSNRNLSNILSTFDTLPQTTQSYLLFQLLRRSSTSTLQFVNALIIPALKRDFLASLPFELSLHILRYLDVVSLCRAAQVSKKWRMVVDADATIWRRNLEKDGFSFTLEEVKRVMARQAMIRAQRKQKMIVLGDHRDNASIATMDVDNPEESRLLRKAIAECDHICVNTSDDAALASQGAGPTNTISGSSSSSPLEPSTPHPYKEIYRQHYTIRQNWKRGRATHMSFQGHSDNVVTCLQYDDDKIISGSDDHCINVYDTNTGKLRKTMSDHEGGVWALQYVGNTLVSGSTDRTVRVWDIERGVCTHVFSGHTSTVRCLQIVMPEMIDGRLQPAYPVIVTGSRDSTLKVWKLPDPVRDEPFLAHNPVNPWFMHTLTGHTQSVRAIAARGNLLVSGSYDNTMRLWNIETGRLIHLMEGHQQRVYSVVLDIDNRRCMSGSMDSTVRIWSLDDGSCLNVLEGHSILVGLLHLTPKHLVSAAADSTLRIWSTETGVCEHVLSGHQGAITCFQHDGHKVVSGSEGGLKLWDIKSGMLVRDLITNVTGVWRVAFDERRCVAAVHRDRVTWFEVLDYGVKGFEDNEIVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q122</accession>
    <name>A0A8H7Q122_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_006586</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q122"/>
    <dbReference type="OrthoDB" id="21221at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="6">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="170"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="5">
        <location>
            <begin position="312"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2183580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="609" mass="67195" checksum="49D106D7682210EB" modified="2022-01-19" version="1">MTSVKLYVYDLSQGMAKQMSMGLTGRQIDGIWHTSVVVFGQEYYYGQGIMNSLPGTTPHGRPIQVIDMGETHLTEEIFIEYLNSISSEFTAAKYHLLDFNCNTFTNDICQFLTGANIPAHITDLPADFLNTPFGQSLRPMIENMFGPSTHATPNLPMQPQSAPSQSSISMLNNVSSAALSASPATANPIQTIQNGASLESLIKSQRGVLAFFTSATCPPCKMIEPDFVRKLETINQDRIKVVGAKIDTQVAFDAAQRYEVRATPTFIAFVDGKKFAQFSGANFAELNSTVDLMVFTMYPPHCHRKLNLRAVLKITGDPILFTNAGNLDNILKKLLSFLEEDNITLSETEMRTLKNAKIAVDNRLQNEVSELDVKAWDDLLITLTSKLPIDHQFPLLDIFRSLLLVREVGNYYTHDCKNIAKFIDTAASQDVKKPTLLMTLRLICNAFAHPVLARTHFSSSLPDSHRTAATNLLIKALLSEDATVRQTASSLAFNFSCVTAKDRLDCEASGESPRDDEDWEVEVVSAVVSALEKESEGEIVYRLVSTLSKFLFLAPSTSPVPSLVSILDIQAAIKDKQSLATGTIDKNKITSLAREIDELVQASLQNMDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1L3</accession>
    <name>A0A8H7Q1L3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_000346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1L3"/>
    <dbReference type="OrthoDB" id="2285317at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2184437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="116" mass="13572" checksum="A9A6EA50E88EA21E" modified="2022-01-19" version="1">MVPSLSSLLHKLSKSKNSIHDRRPRSCSVESSSVKSVHFQDFVETYESYSSTEYDRRPSEELDEYHAPSFVPCTVIEEYDDERDPDYLKLVEKNTRINQKLGHHSLAVLISYRSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1X9</accession>
    <name>A0A8H7Q1X9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1X9"/>
    <dbReference type="OrthoDB" id="2369382at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="627"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2184427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="765" mass="84706" checksum="8AD8632B455E12E4" modified="2022-01-19" version="1">MALLDMTVAKVAAMISAGVTLVQFTYALALVIILIYLMRNDNSPSTWSVFVRILYYSSWSTILSTDVTSTSHTDKPVKRINMLSNIIMILVTITGVITPLGLMPVISQVPMELSLHLLPDLQPLSQAITNRSLYVEERMCDSKLLIGAAACPGRTVTNITGRWETDLTIPQNITDIFTSTNHTSPFDLQFRRYTMSTNGMNSTSLHPVPDIAISDSVILSNSLFAVEGLIIDTTESPGVGIGNVRVPYLPHGATWEQEMLWIEPETACVDLGFTLNYRLNEYADVSFGVKYNLTDQGGLSDFNFTYQSYGNDGQQIPMEDRAHKLAYFSNRYIMNQYNISNTTSYVGKNWPITSLIGMHPMQIGSFPSSFISDLLSLSPNSSVYGLNALNSADISCQGFGGMDDVNITNTAVQCYIFVGAPIRTDGGDSNLVEANSSWLQPVYACASTVRVKLQTLKVSFNTTTNATANLPNLKLERQDTNASVLWAVEHPGMAIRQINPYWGPVADQYEYSTSLNTLRSDVLYLPAGVNLIWDILSTAEASVFPAYALYMSGSGSQSTSSKYVYDYSGGQNGAMLQLWQNLSASADTVSRITNLIWTDIMANNLYSNISIQSTTVMKNVPTVGYNLLYAIPAFISLALWISLIGVSIMCFALDRISISSIRQALYQTSLGRVVVNITTKSSNYALKSKQWAMQESTHNIGLNVTTNGRHDHIQFHLEPQAKSFWQILNESKKTIRKRKYEPQVSDPMELYPLDPDSDKNHPTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q257</accession>
    <name>A0A8H7Q257_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_006321</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="11"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q257"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000238">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="238"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2183316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="572" mass="65082" checksum="9F21AF0AFA5A48B9" modified="2022-01-19" version="1">MSEQPAAPANDQNLHKDPLTGEMISKSELKRRQKQREKEAAKAAKVAANPPPTAPKQNAGEGEEELSPNQYFEIRSKAINKLRSTQEPNPYPYKFHVDISLPEFIEKYNHLKDEESATDVTVQLAGRIHNKRAQGAKLRFYDLHGEGVKIQVMASASDSESDFVAVHDLLRRGDIVGIRGYPSRTKRGELSIRPKDIILLSPCLRMLPKANYGFKDLELRYRKRYLDLIMNNNVRDKFIMRSKIISYLRKFLDNLGFLEVETPMMNQIAGGATAKPFITHHNDLKLDMFMRIAPELYLKMLTVGGLDRVYEIGRQFRNEGIDMTHNPEFTSCEFYQAYADMYDLMETTETLLSTMVEALTGSTVVKYHPEGPDGPELEIDFKAPFKRLDMITTLEEKLNVKFPSADTLETEETQKFLSDLCIKHNVDCSAPRTSARLLDKLVGDFIEVDCINPTFITGHPMVMSPLAKKHRERPGLCERFECFVATKEICNAYTELNDPFDQRERFAQQAKDKDAGDDEAQAIDENFCQALEYGLPPTGGWGMGIDRLVMFLTDSNNIKEVLLFPAMKPEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2C9</accession>
    <name>A0A8H7Q2C9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_000770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2C9"/>
    <dbReference type="OrthoDB" id="2263392at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2184857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="494" mass="56558" checksum="4D588567B4C71760" modified="2022-01-19" version="1">MPIVGHDVEVNNGEAEIVFSITTPEYNLHERMSAKQTLFLDPSIVHVYEELSFDDGPKQTLKADRGTMPVDAQRMIQNYIEEGHTQGALEIFSSSIASGRCPTPKMINMLVNIIIDDDSLNLTITKRMSLCVKVVELLAFILDTHGPKSFEHLWTSFSNSKQPKDEEKSADDLVGQTKCYLSQYDGFFKFVKSVLQPNADELSRERSRQHGLLLGFLVSILELDIRLRKKSYIDMQQAVIVQLLERDAFKVNLVNELDSIFSCYEISVNPTETLRDDLQISNHPEFQYSSRLMNLFIICAYTEGLLKTKNFEEDAYRHFARLRGQQCSYFLESISNPTFVTTLCSLAFSDSDLSLVPDSALQYKHNRTQVLNKIFKFDMLTRPISVDSIEDIWRHVIIMAKRISSYLESKVVRYDFQSAKKLCTYVTSGLTEDEMSLIWENAPGAVEGWRAHITVMLNEVVARAYKGYSPQDIRELRETIEMTMDMTQMSLEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2L8</accession>
    <name>A0A8H7Q2L8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_000299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2L8"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2184390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="307" mass="35100" checksum="E133C7645D1EEA44" modified="2022-01-19" version="1">MTVKTVAIAGAGDVAKYLVEELMRTNHRTIVLSRANRDWFVNQRVEIRITDYTEASITPLLKDVDVLISLLRDEGDFYITAHLAMIAACNMSPRCKRFIPSEFGGNIEDYPQQPVFHVPTHGPIRKVLASQLKFEYTLFNMGWFMDYFIPSDKTYLKPLPDIWPLDVKQKTLRLLGSGDEPVTFTAARDAARALARLVDVPTWPIYTYVAGETTTWNQVLRKMEKRFQTKFEVSKRPQSEIEKSIDNFDDGDIESIGLDHMDLWNATGAVGLPSDKTEQQRLTIFNNMEFMSIEEFMDKAEANDSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4E5</accession>
    <name>A0A8H7Q4E5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Epg5-like TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_000762</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EPG5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="75419at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051436">
        <property type="entry name" value="Autophagy-related_EPG5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058750">
        <property type="entry name" value="TPR_Epg5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139">
        <property type="entry name" value="ECTOPIC P GRANULES PROTEIN 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139:SF4">
        <property type="entry name" value="ECTOPIC P GRANULES PROTEIN 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26573">
        <property type="entry name" value="TPR_Epg5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epg5-like TPR" evidence="4">
        <location>
            <begin position="1104"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="62"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2184849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="2375" mass="270695" checksum="80ECAD8B9FA06ED7" modified="2022-01-19" version="1">MESAEKLALQDRDTTWAAEIVIQPTFTCPTGSSQPQYSQELVDSLLDFEAKHILEPYTCHKLTQLLREYHNCVNEVQSLQETITKLQSQAQERAKRLWLVENKSKTLQAKCGDGIEIKHTFHYNTGQFQVAESAKLSKLLYKLRSDANTLLYRKLYETKMAKIQVQEFIDRFLCETKVFGKSVATKSEQSGNYPYSDIQHKPEQANIKELLDILFHFERHFTQLQRSENGTAEIAKQLGNELIPLAAPIAILDDVHGWIIQLSIPYIKFSDLVDRRYIFQHLVFSPGIENWAKDILAYLVTSEQSRLVEIEIATIVEMLGCATMLKKSGTSTEQSKTTVCSLLWEEDYSAILDQIAIPDRLNDVVDRAILTDPVSLQPKESIGDLVHPVTLANAYFQCLNNVLLQLSKSTYTVLLKRLAQTICQLSHTIGRLVMWNNQRNLQDEVASTLQTEADSLVVKIFRCYLSLPNIGVHYFLSSVPVRSVSVEGLWNVVSEVFKVAPNPKVEFPTIAFDIDHFCQLLLANASEGVFLLQCLANISLVIEPQEHLICEQTEYSTRQQIILAVAYVFFHVAYLNDTMRDMFYKDVRDTYEMMCGRHPLLISSLLKWTVNDFDKIGNNALYLFRSLNLVEWHITQEDIGSLQQLLCSGESSELGTNFTKYIIENINYSYKDEVESEPHSRAKPWEKRNVPFLPYSIHSEVAFMILGIAQRIQPTAEMFERTVASTSTEALTYAIAPYIPTANDAFVSASDMKRRQYMDWCWCIILRLQLFECPMQKRAMEIDESISKLGIGEHARMSNDLVASHLCLIVYTAFMLSSTSRNFLRFDMNRGWEKIQLMIRGNHGGAVIHMFANVVPGFAYMHGDDFFNHGSTSQLLDQILNAKVDASLTEASKSYLKPLKSNVELLLPNNGLEVILGSHAWMAKKIDLADSLAEQGGFSYLDLILHSWIKIVCMQPDWMWKPNRISLLNYIAKLAFTNGRHDIIRGMLEIESQRLELVRHSSSSSPSKTGQDSPRNPVRFMKSVLADATYPSLLTGEWSMMSLASSSLFKTPNVEQHFFYFAFEALLQETIAETKTRKQLALQLKADVAIRKLKDDMEINSVIKRSGINLRKSVEFLTIYRWLQHILVMPANHNLLPLFLQMFFSLYFCNIGNDEEKSSFFFGHLLFSKRENQIDQLKKHLAQLKELPANTDSKGVSVILDEDQTMKKRESLYHAMYLWLGDARLQADTDAIDGLPASYLPSRLTHCRILGSNLGDPKFEAKNLFDGSTLWMDLVSLDQLEMEFDDFPWVSKVSVYQPVLPASRPGSSFDVRSHTPTKSTHLAVITIPSIKLKRPVTALPLAEILELSPQDLFGDMLRIFHTHARQFEQLSIQYKSLDSAYLKQLESLYLNKKITSTFQVPCKKVPEGICRKPATFHLDQQELQVEEDVEKQLSDNRNQVSKLVFTHIDPRICVQSLQALTTMTEITKLNNDQLSAAQSKKACEAVIFLFEALRDNASEFPPAKLLCRQFAQMAASSFRLHPELTDTLVQHMGMDDRYINLLYPAFEPISQPSQFVDLYKKICLGTDYSCAGQLKLISKFDIVKWVSTNQGSSKKQRLLWYQVAFKAIQKLGRTSNDRPQDRALSYRHSSLAVKLLENAYEKFAVEYEYVDVLALIIETYSSRPMNTYHLRAFMEFLGVPLDFIRRAISPCQQNKDITLNTLDRDGLIRVLNVIVDIWSKEDHNCLDYLYNSAGSLYDLVLACLCDIRLTMDAPEEIAHSSALQIVFDAHRPLMMSGSANRSKEFDQVAEGFLITVKTIIASRNSKNDTITILEQCLNYYISLQLSTESRWMKILQRDILQLPWKNMTPNSQVLFTLLQTSKKLAQSSDNSYLAYQQFVTRLLMEWPANNELLGSSSDTIRLYTRLHFIAVQHIEEAELDGQEVIKVLNTSVLTCIPQFSSDMEFVKGIRRSLRTSWPTPLESFKPSMDATNDHMQSLHYCLVWFRTLTKIDTPESCTLMLALEYITYVTSLLNSFIESPGMNFTNNAIRDVIIDIITILDIMLTREELENKLDMVTAILGDIISLLNRCSSNSEEYTAIRNALMDTVEKLNNIPIAVLHVANLHGIKPHTAAILMEKCVQQELATSPNSIDEIWNLISRHLQILRGDTDDLLHQCLENYCILTLHGRCVAELLLCKTYADECKVAEEVAAFLSITTVPLIVGSETTKLVLLLSKFADIFSKKSKDTKLEEFDLLAALVSVHRTLYQWAEGKDSYHIAQTGLMNTFGDRWRSGSSSAIRIEWKLYSRLLCGYIGRHLAPLTITQSGITNRPTTADSWQEWIDSTYNLKEYSPYSEKTATGFELCQKAPIYQLDKVVRSLAHEIFQAVSGIDLARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4F5</accession>
    <name>A0A8H7Q4F5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_002752</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the clathrin heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2113814at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000005">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000082">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.730:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.110:FF:000003">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015348">
        <property type="entry name" value="Clathrin_H-chain_linker_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022365">
        <property type="entry name" value="Clathrin_H-chain_propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016341">
        <property type="entry name" value="Clathrin_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09268">
        <property type="entry name" value="Clathrin-link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01394">
        <property type="entry name" value="Clathrin_propel"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002290">
        <property type="entry name" value="Clathrin_H_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clathrin heavy chain linker core motif" evidence="9">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="537"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="686"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="833"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="979"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1128"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1274"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1423"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1621"/>
            <end position="1664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2186314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1683" mass="191543" checksum="245773D79EE45DE6" modified="2022-01-19" version="1">MTEALPIKFQEHAQLTSLGVNAASISFNTLTMESDRFICVREKVNETNQVVIIDMANNNELVRRPISADSVIMNPTSKVMALKAGRQLQVFNLEMKSKLKSHVMHEDVVFWHWIDIKTIGMVTGTAVYHWSVEGESPPNKIFDRNANLSGCQIINYRVNSDGKWMVLIGISSQDGRVVGSMQLYSKERGISQHIEGHAAAFAELRLEGSASPTKLFAFAVRGATGAKLQIVEVDHAEGNPPFQKKAVEVFFPPEATTDFPVGMQISHKYGIVFIVTKLGFIHLYDLESGTCLYMNRISGDTIFVTAEHEASSGIIGVNRKGQVLSVSVDENNVIPYIINTLNNTELAFKLASRGGLPGADDLYIQRFNQLFATGAYGEAAKVAANSPRGILRTSETIERFKHVQVAPGQLTPILQYFGILLEKGELNRFESIELAKPVLLQNRKQLLEKWLKEDKLECSEELGDIVKQHDITLALSVYLRANVPHKVVLCFAELRQYNKILLYAKKVGYQPDYVGLLQNIMRSDPEKGAEFATMLANDEDGSLVDLDRVVDVFMSQNMIQQATSFLLDALKDNNPDQGALQTRLLEMNLVHAPQVADAILGNEMFTHYDRVLIGGLCEKAGLYQRALEHYSDIHDIKRILPHTNLLNLEWAVDYFGRLSVDQTLECLKEMLATNLRQNLQVVVQVATKYSEQLQPHNLIDLFETYKTNEGLYYYLGAIVNLSQDPLVHFKYIQAACRTGNIREVERICRESNYYDAEKVKNFLKEAKLSDQLPLIIVCDRFDFVHDLVLYLYHNNLQKYIEIYVQKVNPSRTPAVIGGLLDVGCDEDVIKNLLMSVTGSLPVDQLCEEVEKRNRLKLLLPWLEIRVNDGSTDKDVYNALAKIYIDTNNNPEPFLKENEYYDPRFIGKYCEKRDPYLAYICYQKGQCDYELINITNENSMFKHQARYLVHRRDTTLWQHVLQESNANRRQLIDQIVGTALPECSDPEDVSITVKAFMAAELPNELIELLEKIVLEGTAFSDNKNLQNLLILTAVKADHTRVMDYIDRLDNYDAPDIANICIGADLFEEAFTIFKKYNVNSSAINVLIDNVGNIDRAYEFAERCDQPEVWSRLAKAQLDDMRVKDSIDSYIRANDPSNYVEVTNYAQRADKYEDLVRYLQMARKHSREPFIETELLFAYAKTERLADLEEFIASPNIAQIQQVGDRCFDAHMFEPAKILFSSISNHARLATTLVYLGDYQGAVDCARKASNTKVWKEVNAACIKNREFRLAQICGLHIVVHAEELEELIKVYEANGYFEELISLLEAGLGLERAHMGMFTELAILYAKYAPEKMMEHLKLFVSRINIPKVIRSCENAHLWRELVFLYVHYDEFDNASQAMMEHSPEAWEHSAFKDVIVKVSNHELYYRALRFYLNEQPLLLTDLLAALTPKIDHTRVVQIFEKSDNIPLIKPYLITVQQVNNKAVNHALNELLIEEEDYEGLRDSIDNFDNIDTIDLAQKLEKHELLEFRRIAAHLYKRNKRWRQSITLSKQDRLFKDAMQTAADSKNTETAEELLQYFVEVGNRECFAAMLFTCYDLMRPDVVMELSWRHNLNDFSMPYMINTMREQFTKIDILSKEVKELKEKAENQENAPAPGPVLGGPLGNPLMLTAGPTGGMMPQQSPMMTGASPYGMQGSPSGMYGGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4F9</accession>
    <name>A0A8H7Q4F9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HCNGP-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4F9"/>
    <dbReference type="OrthoDB" id="1714508at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012479">
        <property type="entry name" value="SAP30BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464:SF0">
        <property type="entry name" value="SAP30-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR PROTEIN HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07818">
        <property type="entry name" value="HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2185937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="29391" checksum="B52DE4BE7514BCDA" modified="2022-01-19" version="1">MLSDPDSPPPQPVKDKTEDHKLDQNSATNNDKKRPIDVDDSHRSKKSTPPPMSNVKIHSKPAIRPASLPQSAPPSRSQKVGRPSALSEVDTSMDIDDESEDEQLRRRRELMQPTPIPDVDNWGIPAEPQGECDADVEARIAHFLSLRESGTRFNDHLQHSKAFRNPHIYEKLVEFVELDEYSSNFPKEQFDPHGFGTDIDGLLEAQKKSAEDRLLSQQNRSNIQFVTGGPPAGPPPTIEHTDKFADAVARAAQIASKLSSQARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4Q5</accession>
    <name>A0A8H7Q4Q5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4Q5"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034432843" description="Post-GPI attachment to proteins factor 3" evidence="7">
        <location>
            <begin position="21"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2185912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="321" mass="36904" checksum="5CEDBBCE6DDD104F" modified="2022-01-19" version="1">MFRLLSALLALTIVIPAALASTGDQSPQYRTCVAECTATNCPRPIPLHLRALFWTCEHECKYECMQSITQAAIANNQRIHQYHGKWPFYRLAGMQEPASILFSILNGVMHYKYLPVLQQQIPNSYPLKKLYIGWSIVGINTWIWSSVFHMRDFPLTEKLDYFSAGFGILYSLYLAIIRLFYVRNALIIKAMTTLFTAMFIAHVSYLSFVRFDYGYNMLACVVIGSIQTSLWLWWSILQYTPWGDPKRRSYAWIAGFCVVAVSCAMSLEVFDFPPWFGVIDAHSLWHAATIPLVAVWYNFLLKDTSYELTMGGNDRTNKRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4U2</accession>
    <name>A0A8H7Q4U2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_002570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4U2"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1500.10:FF:000002">
        <property type="entry name" value="oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000166">
        <property type="entry name" value="Coproporphyri_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2186132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="390" mass="44272" checksum="8B53F0D15836B228" modified="2022-01-19" version="1">MAVSTPARLTSVHSFHSTSRAATLIASRRNQQVFFAALAATGAVGLSYSILSTDKMTMAHCDAVSDDKKRKSQGPITDRDPMRLRMEAFIKDLQNRIVTEIQQLDGRGEFVRTAWERKEGGEGITCVLSDGKVFEKAGVGISIVYGQLPKAAVEQMRHDRGKNIEADGPVPFFAAGISLVMHPHNPNAPTVHMNYRYFEIENPDGSPKLSWFGGGADLTPSYLFEEDAVHFHQTLKDGCDKFDPSYYKDFKQWCDKYFFIKHRGEARGIGGIFFDDLGDKPEETFAFIKEMGNRFLTSYVPIMEKRKSMRYTDDMKEWQQLRRGRYVEFNLVQDRGTKFGLSTPGARIEAILMTLPLTARWEYMHEPALKSREAELMDVLKTPKDWIPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6B5</accession>
    <name>A0A8H7Q6B5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002511</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6B5"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000010">
        <property type="entry name" value="Acetyl-CoA acetyltransferase (Thiolase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF107">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="6">
        <location>
            <begin position="6"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="7">
        <location>
            <begin position="276"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="4">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2186073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="398" mass="41790" checksum="572366363ADDBA9D" modified="2022-01-19" version="1">MSLRQVYIVAAKRTPFGTFGGKLKSISAEELGGLASKAALASLPANTPISSTIFGNVLQTDTAGAYLARHVGHRAGLPFEVPALTVNRLCGSGFQSVVNGVHEILLGESEIVLAGGAENMSKAPYVVDGDKTRWGTRYGAGLNMEDSLSAVLIDQYPDPTPMGITSENLASKYNITREQCDEFALLSQQRYAKAASQGVFDTEIVPVEVKGKKGPEMVSVDEHPRPQTTAESLAKLKPVFKRNDGVTTAGNASGINDGAAALVIASEEAVNKYGLNPLARIVSWQSSGVDPKIMGIGPVPAIQGALKRAQMSLDQMDLIEVNEAFAAQFLAVEKELGLDRAKTNLNGGAIAIGHPLGASGARILTHLTHELHRTNNKLAVGSACIGGGQGIAVVLERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q7E7</accession>
    <name>A0A8H7Q7E7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA repair protein RAD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_002559</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q7E7"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="417"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="802"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="898"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="295"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2186121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1072" mass="120150" checksum="499612E4D6A9BE2D" modified="2022-01-19" version="1" fragment="single">EEVEIECNDTLSVAGDNDVTSPWNVLRPLVLPETTDQTLADLYEKANGNIEVAVNMFWENQTAEPIPDTKMEEPLFINRIEETEKKVVDRKGYYIGDMIVIDNHIGWSSTKGKSPVSEGDDISLDRVRPNIPAAKKIRFTAKNNRDNTVVRLITLNGVEFGRLPSDAARWISKLLDFDVCAFYGTIVACNSYLSTGDDIIIQLSCYFTEKAFVAFDASDQAQLSMFGISRSTSKAPIFDKGAETDAERLMKERRLAIISLFKSLAIAPVRSSLSKANEILGGEGKVRDLIAQAAATEDKAPANEEDADETAEDETKEVSDNQLDNLYEKAQMMDAKLDEMEPPASIALKLRSYQKQALSWMVRKENVASTTGDSKGSLHPLWEEYAFTHEPSKTSNMQEDEKFYVNPFTGEMSLTFKSADSACRGGILADEMGLGKTIEMLSIIHANRPVISRESSFGKLSSTSTYGMTPTSREPMPSPTTLIVCPMSLLAQWRDECIRASNENTLKVEVYYGTSRESNLLSRLRSWNGSAPDVLITTYGTVLSEWIAEDSTKDTQSILYSVQFWRVILDEAHHIKNRLSKTSKACSALSAIRRWVVTGTPIQNKLEDLFALVHFLKHEPWSNYSFWRAFITIPFQNRDMRAYDVVQTVLEPIVLRRTKTMRDASGNLLVTLPEKRVDIEYLDFTPQEQDIYNSLFTDSKTKFSYFCAAGKALSNYASIFQLLMRLRQVSCHPYLVVKDGINKEVLSESGSVSLEDLIERFQNSSTNSPAGSPANESNSYGMNVLQRLKSQQLDGDNSESECTICFESAESAVLMPCMHMACRACVLDYLQKREDDGLAGECPICRHGPITEANLLEVVKQRKSNLADAVGCSSDGTKNNSSMTLNLRRTNGFKTSSKLDALIRYLRQHAQESAQTDKPVKSVVFSQFTTFLDLIEVAMSFEGLTFVRLDGTQSQIQREKALKEFREGSASTMLISLRAGGVGLNLTCASRVYMMDPWWNFAVEAQAIDRVHRLGQKREVIVKRFIMRSTVEEKILAIQDRKSVLANGLYLGKDDKRTLEDLHILFGNQPIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U6L1</accession>
    <name>A0A8H7U6L1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="15">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_005312</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="15"/>
    <dbReference type="EMBL" id="JAEPQZ010000024">
        <property type="protein sequence ID" value="KAG2171246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U6L1"/>
    <dbReference type="OrthoDB" id="5381460at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01663">
        <property type="entry name" value="Cyt_c_Oxidase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.210.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="entry name" value="Cytochrome c oxidase-like, subunit I domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033944">
        <property type="entry name" value="Cyt_c_oxase_su1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422:SF18">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="Cytochrome c oxidase subunit I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0186">Copper</keyword>
    <keyword evidence="10 15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 15" id="KW-0349">Heme</keyword>
    <keyword evidence="12 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14 15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit I profile" evidence="17">
        <location>
            <begin position="24"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2171246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="482" mass="52772" checksum="8E1686FF043786EC" modified="2022-01-19" version="1">MIGTAFSMLIRLELAGPGVQVLQVMPAMIGGFGNWFVPLMIGAPDMAFPRLNNISFWLLPPSLILLVASSFVEQGAGTGWTVYPPLSGIASHSGGSVDLAIFSLHLAGISSMLGAMNFITTILNMRAPGMSFHKMPLFVWAVLITAVLLLLSLPVLAGGITMLLTDRNFNTSFYEPAGGGDPLLYQHLFWFFGHPEVYILIIPAFGIVSHVVSTFCGKPIFGYLGMVYAMLSIGILGFIVWSHHMYTVGLDVDTRAYFTAATMIIAVPTGIKIFSWLATLYGGSIRFTTPMLFALGFIFLFTLGGLTGIMLANASIDVALHDTYYVVAHFHYVLSMGAVFGLFAAFYYWIGKITGRSYNELLGQIHFWSLFVGVNLTFFPQHFLGLAGMPRRIPDYPDAFAGWNLISSYGSIISIVASLVFIYVVYDLLSKQEFNLASNYWRVPAFFESSRGTSLTETASTLEWSLSSPPSFHTVNSLPVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7X0</accession>
    <name>A0A8H7U7X0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF726-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_006028</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7X0"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="517"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="304"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="865"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1072"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="923"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="935"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1008"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1029"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1072"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1130"/>
            <end position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2174966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1210" mass="131203" checksum="96A0A65183F52535" modified="2022-01-19" version="1">MQQDIASNHSEKEVTEDPIVSTGDQLATSGLNEANVDEMNAFENEKRHSMKEALPSDLNDDLDMAKDDNVARISSEHDDGSSVLPLSEPTHSLTKSSLATQNDLIPPSHTSVLQWASALPTIERPEGASPPPSPQFTPSHIFEISPQEDYDEEGDHRIQETKDVFTETQKIAYVGLCAVTSLEVVHECQGKDFAYARMSAGNWQRKVIRGLYGHMDISQEEITMIESLDKHNILPTDLVHQFTSQGETTTVPVGPMHKVNLDSDAQKDVVDKAPKTSETENDEDEEVDKIDEKHIEELRTELDNVLNRISSPDIEQDTEDAGIVDDSKVPQSEATDTSTHAHNGLGYVSTDDDGDEDVDSEKAELSSQSSGSSTKTVGALDDPSQSKNADKTKENANNIDVLMEEGKPQELVVDLRWTVVCDLIILCLSMNNYDSRSRVFIRKIATYLSLDWHEVIAFERRITEYLASTDPSWETESEMSFATTATDDTATSEYTTVTRHDDTVRKSRNKQHKKRRYIMMGLATLGGGLVLGLSAGLMAPVIAGGLGAVLTTVGVTGTSSFLGGTAGIALITSGATVAGGRIGAKRMFNRTRGVETFEFVTIKAEERVNCIISITGWLTRPDDKEEAGLPFSTLDSLMGDHYTLFWEPELLTELGSAIKIIATEVVTQAIQQALQHTIMGALLAGLTWPLALTKIGYLIDNPWANALDRARVAGLILADSLMNRSMGSRPVTLVGFSLGARVIFFCLLELSRMHAFGLVEDVAIFGTPVSTSMSQWKECTTVVAGRFINGYATNDWLLGFLFRASTGALGSVAGLRPLRDVGVQNVQNMDCTDLIKGHLHYKSAMPKLLKRAGFMVTSEELPEVKEKERPSGVMGLVGFGRSSLTVNDNDSRERSSSNASRASTPSIETDTPPRAASEMDGTIVEKDLEEKETKSTTQQFLNRAKATSLSSFSSGKASITLPNRKPSPSPDVISNVQPSHPPSPIINMRSASSPIPSRDLELLPATSDNHHEQKPTDSEAVPMYRSKSDVTSDSNIYQQPPLESRPSLASLSTEQSDLDLIAGIIANATAAASSKTGSYSSLSSGKASVVPRPSISTSTSTQSITKSPSAEKRAFRDLFGNGGSRAKPSPTLSNSSKDTKQDSASSSFFGKGLFGKRKEDVSDPSQQELAEAGVEVKELKSTLGTMVVPHQVSNPVPKVTLEMPKHARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U860</accession>
    <name>A0A8H7U860_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LYR motif-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_001063</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in efficient integration of the N-module into mitochondrial respiratory chain complex I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U860"/>
    <dbReference type="OrthoDB" id="74240at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd20262">
        <property type="entry name" value="Complex1_LYR_LYRM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045293">
        <property type="entry name" value="Complex1_LYR_LYRM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675:SF0">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="7">
        <location>
            <begin position="35"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2175416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="103" mass="11981" checksum="5F552B466C7AC5C3" modified="2022-01-19" version="1">MPLPSLALRAGMQAAAKKRFFEADGLSLEHFLAKRRVISLYREILRSLKDLNKSDADEIRHWARSDFERYRSEKDVEKIKNLITSGKHQMHSVQKSLMLAQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8G8</accession>
    <name>A0A8H7U8G8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_004629</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8G8"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF21">
        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2173255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="578" mass="65214" checksum="8CE5F17DB0B0CBA2" modified="2022-01-19" version="1">MSTNKSAEVPLGKRTRSSKACTACRQMKLKCDAMEQFPSPCSRCKKSGNFCEIDRNFQRERKRRAEGSKEAQVANLSSIPEILTPQSQISPLIPPVNHIPAKPDEESRLPPIEAKDEIISGTTISGDRIVLMYHMFITHYYRFLPILPLEYVNPAAISTDCPLLFWCICSIVAPSCAPDLVTVIHENVRYLVSTVYLTHYMFKPFTALSNVCALVLLCHWPLSHKTIQEDASWTYCGLATHMALQIGLHRSKFIEEYAVASVTSRNASKMKLLTWLGCFLVNQLNADFHGIPSSASLDYSYIPDPAQYEQDEHVSDFIKRVKILHALKKGIDILGTPDGIIKTGALPLLHRSLEDSFSQLLAEISPLSDLAELTYLHAKLQLHSFLLTPDVPVSEQRNAIIPTYLVCIQHIQIVKRMLDKDPRCRYWPFFIVTNVLIASVVLFKLAISQFREMIDQDVARNHIADSFTLLRKLTLHQEDMAARGIRLIEGIKSMYEEKLISPQICSVKTRLGAGIFTSTLLEFKKWQSMKTPNQEPTPGGSQAAAAPAVPGQSTMWPFFDLMSFDDFWNAEFWPEPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U973</accession>
    <name>A0A8H7U973_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_009074</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U973"/>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17355">
        <property type="entry name" value="MFS_YcxA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="247"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2171413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="442" mass="47685" checksum="F247D6F81CE4B37E" modified="2022-01-19" version="1">MAFSFPKLPSSPLISCTAGAVILWLFFGVRQSFGLLLIPITTDYGWGNCIVYGVGVLILHFCTASLGPLFIVAMGIIVGGAAGGNSFPVVLASIGRQFPQGSKKQALAFGFVSSTGSLGQGCFLPITNVMIQRMGWRNTLLVLGMCLCKATLVTCTCKTNLRVSAALAILCIAVSPLAIFLRSVEQTPSEAITKPIETNENDKSEDKEPRANELSSLEKAEVVEEEMISNQPQSIGAALGEASRSLTFWLIAIGFSVCGFHVSFLATHLPAYLNGRGIDASIAAWSVSILGFGSCFGTAVMGWLCSKYRPKYLLTGLYWCRALMLAIFFWVPLSMTTIYVFSVIFGVLWLSTVPVTTKFIGDVFGFRYLGTLTSLTFIGHQIGAFCGAYIGGVEYDASGSYNHMWYASFALALFAGCANFFANDTTLRGHHPQRVKESDSEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9L4</accession>
    <name>A0A8H7U9L4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1</fullName>
            <ecNumber evidence="1">2.1.1.57</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cap1 2'O-ribose methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_005847</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67020"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="Rhea" id="RHEA-COMP:17168"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167609"/>
            <dbReference type="EC" id="2.1.1.57"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.57" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9L4"/>
    <dbReference type="OrthoDB" id="10251234at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004483">
        <property type="term" value="F:methyltransferase cap1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050851">
        <property type="entry name" value="mRNA_Cap_2O-Ribose_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025816">
        <property type="entry name" value="RrmJ-type_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121:SF0">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51613">
        <property type="entry name" value="SAM_MT_RRMJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RrmJ-type SAM-dependent 2'-O-MTase" evidence="3">
        <location>
            <begin position="341"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2174785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="652" mass="75862" checksum="72F578B53D1E6F8B" modified="2022-01-19" version="1">MNRICTRAGFKYLAERFVACWQVKRFIYRILDICGDSNFCHWSNSESMADPFTDNDPDYRNTRVDSGIPPPSLATIPRVAQHGQKRDRYSGQPENLTSWNPKQQRRDTSYQRHEDPYNRQDRRGDQYQRYERRPDDRGSRDDPRYRQDQDRHRHEQEYRRHEDYRRQEHDSRRREQDSHCHEDYRRHESQYAHPEKDSHGREQDSRRHPYDEQSQRSYHHPSHQSHSESNKYDSPAEQSNKSEELPPPLKPIAAEFKMNTDFLACGEDDACAKLSSVEDIAKHLEIKYSELDDPVDYEFVSSADLAHQVTEAKNRLSGTKHELFTLARSRTNPFDKIGQAIFICRAATKLAVLDVHFNLLASPDSNQTFQFADLCGGPGGFSEYLLWRAHTSGQAIHGYGITLKGENDKNWRLDAFHPDTDVKHSFTILDGKDHSGDICIPDNLANFASHILQQAANGVDLVVADGGTNFQGQQDKQELIARQLLICQTAAMLSVLRKGGKFVCKFFDITLETTAGLVWILYQCFESICITKPLTSRPANAERYIICNNFRFHRPQVIIDYLLKVNEALSEEHARSKRVNAIVERGKMESDEAFIDYMKMRNMKFAIKQLEALENLEQFVQRPHNGTTEPDQNEVRRRCLHEWRLPLQKESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UA62</accession>
    <name>A0A8H7UA62_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2242379at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF160">
        <property type="entry name" value="ERAD-ASSOCIATED E3 UBIQUITIN-PROTEIN LIGASE COMPONENT HRD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="35"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1668" mass="184647" checksum="43AFAE41DEA0B561" modified="2022-01-19" version="1">MGAKASKQYQQQERPQHRQIKVHNHSRRRSPAHLHTTRRASLSSSCSEHTLPSSSSSSVAEDFRRHHMPAALLPVLSKNDYAIGDDNNISTVTASSSGFNNSDISALFSQIDNASSIASGSISSRATTVSSHSSCRMGDKFLPPPYSAGQFTKVNYLQIINGLIPISSSGPTNVREELSQSTTSTSLQTDVILSQPHLQLMGSAEFGDTNTSRGSTTSANTDISHLSKSSTITSTDSQPHQLSHESILGELRQQRKLNARATSPIATSLSNTDPSAKSIQSILEFAFTRAQDLDDPTDYIEAYQATRCFADESNDPIARVWVAQCHLNGWGVPRNPTLAFQTLSSMARRNILNAYYPTGCCYYDGAGVPQDLTKAFYWFELAANCNEAMAQYRVGSMLAKGEGVKENAAQAFEWFRRGADNGNKYAQYIVGLHHEQGIMCQKDQEKARAYYLLSAEQKFPDSQTSLGVSLIQAGEHAQGLKWLEMAAQKDNARALLKLGIMYEEGDHVAQNNDLAVMHYKAAADRNDPVAQYLLGLNYRLGDLGLQQSYPDAVTYLQKSADQGFASAQRVLGLMYGEGVGVTQDYQKAIEFFKKAAEQGDMRANGLLGAYYENGYGVEQDYIQALDYYTKAASTGSDAAEFSIAQLLHKMRRYSQAYKWYGKAAKRGRKNARLMVARYKLHGWGGLEKDSAAAFKELVHLATVESFQEACFWVAACYEEGGGVEKDLTKAFEFYLKSAESGDIDGEFQVALMLSNGQGVSQNRKKAFDWYSRAARKGHRTAQYSMGLYYAKGLDGVSQDLAQAQTLFEQATAQGLPEAFNSLAALFETQERYEEALYWYKRGASNGDPVSLRQLAMMYDGGIGVSTSHEIAFKLFEKASLQHDAQSELMIGSYYEHGHYVEVDIEKSLTYYAKAEEHGAHIAPFAIAQILHNQGRYEEAYIKYQKAANNRKLANSKVGKTAQLMVSRYVLSYDGPSGPNSPSDPQSKAKALEKLLELAESKFKPAYFWVGDCYYSGNGIEKNMTQAFKWLQKAEAECRDNDAKLRVAKMYKNGLGTEQDFTQAINKFESLVETNHQAIAQLSLGQIYCEGSDDVERDLETAKVWFSKALEHKMADATYMLGLIAMEQGNEEEALTWYERAIDQGHVAAMREFALAYQHGEGSIEQDLSKTSFWLQRAAQEGDAEAMVYLGLAYEHGMGNVIFRNRDKAMQLYQDAAAMGNSNAMFLAAQMFHAGENYTQALELFESAAQMGKVTARVMTARYSLNGLGGTPENPEKGFKTLLECAEADCIEAYNLIGQCYELGLGTKQDLAEALNWYQKSANVCQDLEAMCKIARMYGEGSAVEQSHEEALYWYHQAAEAGAYPVAQYFIGLYHKEGLGGLDGDPEVAKIYFRKAADQGDARAMYELANILWSKRAYTSAMAYYEEAASCGVNDALRDLGNFYHEGVSSSAGSDMCVIPKDYETAFGYFLRASSLNDPTSTILVGAYYENGYFVNQDRNLALKYYKKAVELEGGSLAELAIGQLLHSDVDKRDEAIQWLVQAADHGNPLAELMVALYHLNGWGGVEQDVQYGFSKLLDMAEQGQSEAFAEVAKCYELGVGVEQDLEQAFGWWSEASAMEDDVESVFKVAVCHEYGLGTEVNLTKARDLYQVAANMGYDEACEKLELLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UB45</accession>
    <name>A0A8H7UB45_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UB45"/>
    <dbReference type="OrthoDB" id="10251230at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="647" mass="72470" checksum="91AEFC5449FE103E" modified="2022-01-19" version="1">MASLISVQETPSLRDAQFAAIVAMLNLNKSSDQYTVSASKPNEDGNDEVIWKVLIFDQFGQDIISSVMRVNDLRDNGVTVHMQLKKDRSALPDVPAVYFVEPTSDNVKRICEDMKKDLYESYYINFASSVPRNILEEFAATTIATNTASSVAQVYDQYLNFVCTDANVFSLNQPRAFVTLNDHTAAETTIESTIDSIANSLFSVLVTMGVVPIIKCPRGNAAEMVARKLDTKLRDHVMNSRNNLFSESNSASVQRPVLILLDRSLDLVPMLSHSWTYQALIHDILELKLNRIVVESEDRNPKNRKTYDIEAKDFFWNKNASNPFPQVAEDIDIELNKYKKDAAEITRMSGVSSLDDVDQADFSSNAKYLKSAITALPELTARKATLDMHMNIATFLLNGIKDRQLDSFFQIEEVIARQNKSMLLEMINDPQKKEPSDKLRLFLIYYLTITEEIPKDDMAEYERALAGAGCELQALNYIKKVRAFMRMTSVAASTAPQAGYQNELLRGFSSIGNKLTDRLKEGGLGGGFENLLSGVKNLLPSRKELIVSKIVSNIISPINEISEVDDYLQFDPKLGKNAKPSRHKVAYQEAIVFVIGGGNYIEYQNLQEVASFSEQRNNLQKKITYGSTDILSPSEFLSQLQALGPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBT8</accession>
    <name>A0A8H7UBT8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBT8"/>
    <dbReference type="OrthoDB" id="2390549at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034233200" evidence="2">
        <location>
            <begin position="21"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2174158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="636" mass="70443" checksum="6BB7225FDB62B426" modified="2022-01-19" version="1">MNRLPGYLILLLLLVTLCSGSPISKRQYNDDQNGKNYLRIATPNSGTIWQADSFQSVTWVLNGNANFGYSESIDVILLALDSSDNWKQVDTLPSATAGGGISNYHVRKDLGKAKAYMVVLEISKIGYRVRSEQFKITAVSGHNNGDDNSYDTSTGHYESDYNNNQDGGSYSGHYESDYNSNQDGSWSPGDYESGSTSGYDSGSWHHNSYDQSDYSSSSDEASHDSYNDKKPLSLVTPTSATVWQADSYQSVTWKFDGNSHLGYGEQVSVYLLALSESGDWKHADILPSGTTGGGISNYHVRSDLGKAMAYKVVIEIVAIQIYIESEEFRITTISSHSDYADIQDYKKNDNKNYLRIVTPNAGTVWKADSFQSVTWAISGIPNFGYSERIEVILLALDASGSWKKVDTLPSGTAGGGISNYHVRKDLGKAKAYKVVLEMSKYGIHIQSQEFKIQAISGHSNDEWNSYDEDGSAHGTDDYKSWDDDSYSDKSHNEDYDTDNDSSYQSDYDSSEHDNESDSYSDHGNSQTLRKDYLRIVTPNSGTVWDADSYQSVTWATNGGPSVNYGLPVEVYLFSYDSSTKTVKLADTLPKGTVGSGISNYHVKSDLGKADWYIIVLEIKSENYRIHSKPFVIKKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UC60</accession>
    <name>A0A8H7UC60_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UC60"/>
    <dbReference type="OrthoDB" id="5562028at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2174174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="18717" checksum="481F7F1C104EF56D" modified="2022-01-19" version="1">MGSCCSKQSHDSEREPLLPGADGSNHGAVGNQPSIPYPPAPAIDYHKEQEFWNTVVERTEQQLIDISSAQTDLLQNQDAQERSEKYQDIISQIQNDIPWSNVVGPNIPKGQLSSSAACDSLLNAAPNGGLGEEQMNWLYQAMDDIQDAVANINVRPVGEIVVNLNFSDNAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCG2</accession>
    <name>A0A8H7UCG2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Serine/threonine-protein kinase RIO2</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Serine/threonine-protein kinase rio2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">INT43_003092</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCG2"/>
    <dbReference type="OrthoDB" id="10258631at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000053">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000307">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="20">
        <location>
            <begin position="65"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="318"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="372"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="403"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="463"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00068353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG2177845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="497" mass="57103" checksum="F3EE684EE657AC0F" modified="2022-01-19" version="1">MKLDAKALRYMSSEDFRVLTSVEMGSKNHEVVPTSLIAQIAQLRHGGSHKIVGELAKRKLIARVQNAKYDGYRLTYGGYDYLALKTFSKRGSVYSVGNQIGVGKESDIYIVANEDDEQLVLKLQRLGRVSFRTIKSKRDYLQKRKSASWMYMSRLAAMKEFAFMKVLYENGFPVPEPIDLSRHCVVMELIDAFPLRQVDEVANPAQLYSDLMDLIVKLAQHGLIHGDFNEFNILIKDTGKPILIDFPQMVSTSHANAEYYFNRDVECIRVFFKRRFGYESLLYPKFTKHIEKEFDLDIQVAASGFTKKHQEELDEYREALGENEGEEDSDVEADDDTEDEEEGSETDSNRKEMTEEEKAEERLRNLRLGNDLSDDEEHSEDSEENEYSNEYASDNGDSDDEEEHRPSVGDDMLKPTDNRNFKAYRDANKVEKAKKPKSKGALDEEAIKDKVTRALKGQENRQTGKHHSRRNLTKGKEKRKNKDVIKHARNGNGSIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEF6</accession>
    <name>A0A8H7UEF6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_003732</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEF6"/>
    <dbReference type="OrthoDB" id="515887at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="338"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2179945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="521" mass="57335" checksum="062608E0EBE7B360" modified="2022-01-19" version="1">MYLNCKLLFAAVYAVMSSAPPYLALFYARIMHFSSDQIGVLLAIAPFVQSVACPFWTHVVDKRPHWHAPLMGTLCIMGGAAILFVMYLGKQTEEKNRWTLEISMLWLTSACVFCYAFCSGTLVSLVDSAVMKILGANKIMYGEQRLWGSISAGLTVFFTGQIVALWNNDLYAIFIVFGLSSIMFILLAFSTAIDDPEGYARSEYSDESESVSPLLRSTTNNSKNEKTYGTSSSYQRLLLPAEGSGQPANINLSLNLPQSGYFDDLLQSLSKSMSYASISSLAKTVREEADDYIEETRTLTMGLALSRLPSMEASMAGILPYPQQEVEAPSAEMMWNRRIVSFLTTVFLYGVTLAMINQFLFLFLSKDLGVASNWLGLTGPASAIMELIMFLFCKQLTERFGVTKLVVVAHLVTMIRSLAYTFLVPNLMVTNFLALILQFCNGIGFALFWATAVSEVDNYFPPTQRSVAQGILAGLYGGLGTGFGCFFGGYLFENYGGAVLYQSAAITSVVGIVVFLIGRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFC7</accession>
    <name>A0A8H7UFC7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFC7"/>
    <dbReference type="OrthoDB" id="73168at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229:SF1">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="260" mass="29797" checksum="131D606EBDF4FAC0" modified="2022-01-19" version="1">MRARLFDVTVASQIRAQSGGQSGIDTFYDKGDWQFSEHFKSIHFTTYLMATSLLLPASYLGGCIAAMSAFSYVYRRATATSEVEPWFGPNIEKEQYIALLNSTTTVPEHHLRAALLRRAVAGVKRLVHIQQEKPPLQQLLRTGSVGDDLSRQFNIAEQETMAELQEIVAEANTYKEGWGQTIFTTAAQMVEHEKQKVILDEMKTRKEEEERLAKLNAEREERDGKDRQEREAEKRERESQRAADELLKQEEVEKKSKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFE7</accession>
    <name>A0A8H7UFE7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_008577</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-25S rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRM RBM34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFE7"/>
    <dbReference type="OrthoDB" id="442677at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12395">
        <property type="entry name" value="RRM2_RBM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034221">
        <property type="entry name" value="RBM34_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF25">
        <property type="entry name" value="RNA-BINDING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="140"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="245"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="323"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="344"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2180995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="420" mass="46804" checksum="CAE03DD031A9A68C" modified="2022-01-19" version="1">MTTTYTPGALSQSLFGSKESAVDNTVDELFKNSAGPSQVVLTPAFSNTSQATAKVDSASAKLDPAQTAREAVSKAKSITEIITEKKKEKKDLKKRKAEEEKIAEASKKAKLEEEKVKKSVEDEKERQIKQKKEEQEKNERTVFVGNLPVSTIQKENYKDLKKTFAEYGEIVSIRFRSIAFSELLPRKAAFISGKLHPERDVLNAYVVYTDKASAEKALEMNAQVFHDKHLRVDSAANPKNHDRKKSVFVGSLPFDAQEEQLWEFFKECGDIENVRIVRDAKTNIGKGIAYVQFSDRDSVDLALQLKDKKFGGKRKLRLDRCKLSVSEGGKPSNMNDKRGGKGAKGANGANGAKGARSSNGQQNSKPQRKFTNSKNTNENLSASAFEGTRATKDDKSAHKPKKHRIRARTIAYKQKTKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFR4</accession>
    <name>A0A8H7UFR4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin Pom152</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003794</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFR4"/>
    <dbReference type="OrthoDB" id="5529162at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056541">
        <property type="entry name" value="Ig-like_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056542">
        <property type="entry name" value="Ig-like_POM152_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056543">
        <property type="entry name" value="Ig-like_POM152_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056544">
        <property type="entry name" value="Ig_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037701">
        <property type="entry name" value="Pom152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056540">
        <property type="entry name" value="TMD_POM152"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206:SF1">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24312">
        <property type="entry name" value="Ig-like_POM152"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24519">
        <property type="entry name" value="Ig-like_Pom152_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24527">
        <property type="entry name" value="Ig-like_Pom152_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23664">
        <property type="entry name" value="Ig_Pom152"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24097">
        <property type="entry name" value="TMD_POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 N-terminal transmembrane" evidence="3">
        <location>
            <begin position="27"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 first Ig-like" evidence="5">
        <location>
            <begin position="167"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="4">
        <location>
            <begin position="411"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="2">
        <location>
            <begin position="504"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="4">
        <location>
            <begin position="713"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="2">
        <location>
            <begin position="832"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 ninth Ig-like" evidence="6">
        <location>
            <begin position="1039"/>
            <end position="1118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2180007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1218" mass="137676" checksum="0980E5AC2BCD91B9" modified="2022-01-19" version="1">MTTSTITPRRTKSHAASRALIPDRFIDFPSQRLWAVAIFGLLQAVKVVDLVHLYWTWQNGNYGTLLLKWWSFDISYLFALWIVKIPWLQFSNTKTLVLALFVLITNPIIFALPSAIANGTIIQFFTGGMMGHQLAVSRGISVRVKDVTLNSSHILGRHTVDILPYSTAKLNPDNQYYCIPSYEVGKDDGIMLRIILNNTIPKHVTLSRFDFENKVRTNVDFSHRDLHRATEVSQGQQGLEVYHIRVRKPGAYRLESITTKDQLDVRLQPNDALVFTCPSAEFLPLPRRDYCRKEQQPLTLSVAGVPPLTVKYTRRIGDSTSHHQIDNIQPDSYISPFVNHDWTKFSEKPVVFSTDDDMDWAATQHVSLMLNLTLTTSSQYQYQIETVTDGAGNVMEMIDPVPANLDVHSPPSIKFQCDLQRPAKLLIGSKSVELPLYLQGEAPWKVEYEFSNIESAEAARKTASLDSQVSTISVTQPGDYKILNVEDKFCKGDVLYPSVCRVVQPPLPEVRLDANPIPSQCADDNEIGMKFVLEFQGTPPFNLGYTIHKQEGRRKVEVQQRFQKIDQSRYVFSYLPTTSGTYYYDFVRLDDSNYKERSTQIKQIKQVVHPQPSAKFSDRLTRGGVIRTCIGEGVDLDVEVGGAGPHTLYWNIFNSGERLSYQEVVTDARHTITIPPSDTGGKYVVSLAKIQDANGCSKELDVPDVTIEVRQDRPTASFYTYDGNDDYITIVEGSNARLPLRLTGERPWRLLFRNVDRNPDKVYHAQLNDANDQLTVKDPGRYELVNVQDSYCPGDVSNTAITISFLDKPALGISEDQVSYKQHGIFERAPVCEGTDDSVNVHLSGHGPFAVSYDLSHSSQGRRDFSRISTETIHSGLYRTRIGLNTYKSGVWRYAFNRLADEVYTNPSTPYTPDHYPIILEQKVLQRASAKFVTKHNEQRMMCVGDSLDSGEINPLRMEFVGQAPFSASIRVRHQGDTHGRMHHLEDIQTTKYDLRLPYELQVPGEYDIEIQSVSDAAGCQSSSLGPNAIIKVLALDIATIIPVDQSTEHCVGDQLEFTLSGVGPFTINYQFNGRPEKIQSPSSRLSTLADKPGNFTIMSVGDQRNKCRSYPRDLSKIIHEIPSTRVSAGKDTYENIREGDTSQAVVDLIGTPPFDFEWRRYELVWDSKHKRHSKGKVMESHMVHGMESHRYYISISEPGTIEIVSVKDRYCQYPRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UG99</accession>
    <name>A0A8H7UG99_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enhancer of polycomb-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_000584</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the enhancer of polycomb family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UG99"/>
    <dbReference type="OrthoDB" id="435275at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Enhancer of polycomb-like N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="534"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="800"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="545"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2184671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="823" mass="91651" checksum="660030CB87981574" modified="2022-01-19" version="1">MVSRFRVKKLSPKHPLTIYKESQLPDIHDAGNLQRAVPLIETGVDKEEEDEVRTACLSLFPMGMVPIGPHDLQAAISAAQAAVTTGEAVQLYIPTPDASITIKEDEYKALYKKPFHPPTSYIKYSTTVEDAIGCLYDMDEEDDTWLTSFNQDRSANQKISEDQFEQVMWELESLANDTMPFLSVDPSQIPPFDELESHFKTPSLLPLQTAAKHIYEHWKERRLKNAGKPIFPSLKYDESGMRSDTDPYVCFRRRETKPVRKTRRTDQQSLEKLRKLRAEMETARNLLEMVLRREKMRKESLAIEHTVFDKKCMLREMQRQLGIKEDEDLLFSKKKRKMSTESGSGATIKIPLSKLKRDGFDRHEKSAAQIAIEAEVAKRKDEDSGFEDVTDSPYQEFPIPLPSQFLRNVLADDSISLHNESLDSRQPCYRKRVGRGGRIHIDRIGLATQHRKHTGGKTRPSDDYERAVKRFKYDSDEMSDDEEEIDDMEDRLLRYRCQLLGEPDLRSLVTIPFINPSMTYPPGGMMVNRANAQTNKPPANVPRPNGSTTATSPSLPARTVNGTATSPLRRQNSRTKMTPQQQALAMTNGMIAANMAAAVNAPNKASLQLAMQQQLQQQMQVNGGSLPAGMTSALQKKMQAAAMMQQQRAAAAAAAGNNANGNANNMSPIQQANMLKAANGQNGGLNLKLQNRATPVMQQNYNGQQQNSAMNLAQNAASQASNVLQQVAALRNANGSSPSMLNGMQAGSPTMNGSPQFSQQQLQQLQQQQKQQIAQMQAAGSYASPMLGLQSSPVMISAGGSPQQMAMQSPNLQMTAQQQQRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGH2</accession>
    <name>A0A8H7UGH2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_001867</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGH2"/>
    <dbReference type="OrthoDB" id="406631at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF40">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034678793" description="mannan endo-1,4-beta-mannosidase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="7">
        <location>
            <begin position="36"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2179018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="459" mass="52422" checksum="30828AD9970D213A" modified="2022-01-19" version="1">MSLTFSMRLALLLQILTTVYASNIVLQTEQQIYGNGFVTVSGTKFERHGRPYNIAGANYWQGMNLASDESAGGNISRIEDELTQLENIGINNLRILAGSEGPDDQPFRMRPSLMPSPGKYNEDVLTGLDYLLDAMDRHSMTAVVTLNNFWQWSGGFAQYVSWADNNSLIPYPPSWLPDPENRYSNGSYSEFFDYASRFYKDPAISSTVDHMFKSHIDTILNRKNTVNGKIYHEDPVIMAWELANEPQLAPKEWTYEIAAYIKQRAPKQLITSGIEGKYGYEDFYNTHSSVNIDYTTCHLWVENWDEYNASDPTDASMQNAFTYALEYIHNCSDWAVGMGKPIVLEEFGMARDAWRFPSEPLYKYNPGTAVSHKDRYYEHIFNIIEKLTSHGAFSGANFWAYSGEGYPSQSPNEFDMVWLGDPQHEPRGWYGVYHNDTTMSVIKDFAHNISGKTEMFVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGJ4</accession>
    <name>A0A8H7UGJ4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_008441</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGJ4"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="60"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2180862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="371" mass="42325" checksum="DA68F8614EB90AA7" modified="2022-01-19" version="1">MVPRYFATRKLGVGFFESKDRSHLYKKIFTEDNEYGHHRYIDVGDGKKFHVVENGNTDGPLMIFLHGFPQFWYTWRNQLIGLKDQGYHLVAMDMRGYGSSYRAKNRLDYNMKEFKSDVRAVIEALQKDKPEASRNVTLVAHDWGSIVAWHVLADSWKLEKTGQGYINKSVIVNIGHPLIVAANIAKPFKQYFNGHWALELVKKPQSTIKTLRAAFASVFAQLMKSYYVYIFQLPTPIARTLISVRDWQSIGGLVKSIKINKAEDAEIFKAAASYSPPEDPTYALDHAVEYYRHGAVSEGWKVGNSEDGYIEYPVLILWGEDDLALDMHLNLDGTEARVPNVEIKTYPNVGHFLPEEIPDTANEEILKFAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGL3</accession>
    <name>A0A8H7UGL3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGL3"/>
    <dbReference type="OrthoDB" id="2407529at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="442" mass="50975" checksum="1801BA5D70F6DF6B" modified="2022-01-19" version="1">MDRLSPLFGEAVKSDRPVVHRGILPTHSTSVLTSDRRSGTGQVPNTITNGMESYLRNLDERKKDLKTEWRNTNFQSSRSNNDLPQLSADTLDTKFHQISKLKSHKNKISSPTHHQSRNLNENETSVRRFHTPLLDMPTPTRGEVAELESAIGSSPYNRIREWQTEALSETAEISDKWELRHWHLLEYWYEFHENDVEAATRSFYEHESSVKETDNGETGSTSIHEKSSTASINSSFNRLWNDDKSYFNRQQQLPTRPSYMRRKLQPDWQEMNSNKLLASPTINSSVSDRQKRQPELKEITPERELTPPSYDSKYNEIPEPQSYLDKRLLEPVDDGKKYPYPSNSPSATTLITPPNRKNHLSSSRIMHNVDQNIKEEEEEPNLSDTSNGSISRVKVHWYEDPAATPRRGHVRQLLKHLEKGLPMDGSEFDHNIPVYSSKSTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGU8</accession>
    <name>A0A8H7UGU8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGU8"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="1">
        <location>
            <begin position="102"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2182540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="374" mass="42340" checksum="F002CDC03315266B" modified="2022-01-19" version="1">MNEQDRHLDKSVRRLLRSPISDDMIDHVTSKAISVIPCPLPSPPAEDSGYFGKEDKIYSDPLSSDQPASASSYNLRNSQIAESMSEAPPPPLRPGQVQVPPLRDFIANLVKRSRLQTGTFLSTLVYLERLRLKLGSVAQGMPCTCHRIFLATLIVTAKYVNDTSPKNRHWARYSSVFSVAEVNLMEKQLLVLLDFHLSITIDDLLNDIQYFLPEYRGYISPNQRASYAGLPSQPTQAVSHPNRYSMPISLEESNSVRNFLAEANEYLSHGMQEVGSAKLTDSAYSSDDYNEDVQFEPQHRLKAELVAPPPASYRPERPVNKLSYDESSLYFNSNNPYRNKNELDRRQYLSSRSPNTYAPHPLPTAINHFVHIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHH5</accession>
    <name>A0A8H7UHH5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PRP3-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_006837</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHH5"/>
    <dbReference type="OrthoDB" id="10264544at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24162">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013881">
        <property type="entry name" value="Pre-mRNA_splic_Prp3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027104">
        <property type="entry name" value="Prp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212">
        <property type="entry name" value="U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08572">
        <property type="entry name" value="PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor 3" evidence="7">
        <location>
            <begin position="157"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="6">
        <location>
            <begin position="389"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2181912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="59942" checksum="E2BC6F60DBA4DA92" modified="2022-01-19" version="1" fragment="single">VDPKIIEAQLAAKRAEVQAKLAAMKARAGNAQQAVPNAAPPASSARSNMSNIPGLDQADLQRRIAEAKARIAGAGQASPGATSQQRLRGGLSAAPPPLGLDKSGNIDLKAMLDQGIIPKRDFATAKANQNAAASASPSVSSPASRAASADAKKSNPYLAEVPDVRGRRSRHLKFVQPGKFIQKGNQERAKAQLERLKQDIAEKAKLAGVQTELDIPDSILKRPTPPDVEWWDLPLTKNKQYNEIDADNLDLAGLESIITPYVQHPVPIKPPGEDQGQPPRQLMLTKKETKKLRRQKRLEAQKDKQDKIRLGLLPPEQPKVKISNLMRVLGQEAIQDPTQIEAKVRKEMEERQAEHEKANETRKLTKEEKREKTIAKLKEDTSQMAHVTVYKVKKLNHPKLRFKVEKNARQYYLTGMVIASPKCNLVITEGGPKSIKAYKKLMLRRIDWNDLPIPLNADAEDTTMHETEEDEDEEENKCFLVWEGVVKKRAFQRFTWRDMESEKMARELLGGFKVEHYWDAAIMADDEELAARQPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHL1</accession>
    <name>A0A8H7UHL1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Terpene cyclase/mutase family member</fullName>
            <ecNumber evidence="7">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_006371</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="7"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHL1"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000250">
        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000002">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000003">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002365">
        <property type="entry name" value="Terpene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF20">
        <property type="entry name" value="LANOSTEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01074">
        <property type="entry name" value="TERPENE_SYNTHASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="9">
        <location>
            <begin position="86"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="8">
        <location>
            <begin position="388"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2183365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="730" mass="84158" checksum="A643C319C566ABBF" modified="2022-01-19" version="1">MVQSEKFPSALINSVETPSFTDLSRWRLKVEHGAQTWHYLQSDEELKQWPQTRWDKYFLGVPFDSQKLPHPKTPLESARNGFEFYKELQTEDGHWAGEYGGPMFLIPGLIITYYITGTPVPESMRVEIIRYLLNRANKDDGGWGIHIEGISTVFGTALNYVVLRILGLAADHPAMIKARAKLHQLGGATAIPAWGKFWLSAMSCYEWEGLNPVPPELWALPQMLPLCPGNWWVHTRMVYLPMGYIYARRLNPEPTDFILQLREELYTEPYDGIHWDSQRNNISEADLFLPHTKIMDFLNGALTYYEMIPAKMNYLRQYALDLTIEQIRMEDENTFFLDIGPVNKALNWLVVFYHYGKDSREFREHVKRNADFMWMGPEGMMMNGTNGSQLWDTTFIAQACSEARLVEHPAYQPSMLKILEFLEDCQIKRNVPDYKKCYRHVSKGAWPFSTRDQGYTVSDCTAEGLKGTIALQKLKGMPKLISQERLRDAVDVLLTMQNADGGFASYECIRGPKWLEWLNPAEVFGDIMTEYSYPECTTAVLTGLSAFKAIHPDYRRAEIERVSGRALQYIKRTQREDGSWFGSWAICFTYAAMFSLGSLASIGEYYENSDHARRGCEFLISKQKEDGGWGETYKSCETGVYVQHEKSQVVNTAFAILALLDAKYPHQEPLRRAVKLIMDRQQENGEWLQESIEGVFNKNCMISYPNYKFSFTIWALGRYATVWGDKQIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHU8</accession>
    <name>A0A8H7UHU8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHU8"/>
    <dbReference type="OrthoDB" id="2355659at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="227" mass="24933" checksum="F1D32C393DE67A6C" modified="2022-01-19" version="1" fragment="single">HYHNNRSPFISSIVIFRTATLVLAVLGAMSHLWSAFAMTGMLDSLENDTDGLASIYTGLTLYSYGTGFLCLAGAIGVAKNNLRKVRLFAIYYWVELVLNFMLSTSFAYAAFSISQDVCDQVSHTDFGNGETLDMEECLDVYLDTAAIATVALALNLLLKLHYALAVHSYYIKLKYQLDHPELTATDADVVPCPYPGYTPVNTMEKDVNAVAPPAYVAGQKFVADEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIX5</accession>
    <name>A0A8H7UIX5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_000733</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIX5"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="349"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2184820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="396" mass="44735" checksum="CAF760DE93AD9952" modified="2022-01-19" version="1">MSSNSTMAVTCPTEPGLQLHDGLYVSHNPSFNFSNVLSDPTANWIVPDNMDCIPGWIDSTFTKLLVSIVNTIIPFISSNHQPYANQNYSDPEIQRHKVRVLLYPPVYSTLAFIQYLRPDYSTTIGFFGTLFEALAVYNLYSCLKALLEPYYEESAGHKEECRTKVMGVLKVKVYPSISVFNPEYKRGHIPAHGMFWCVKGPIMIIFYVGEILLSILVTAHVIKGTDGSESQDGLAWSPQAVKFGIYVLLVCFVMTVVSILMLKYFGIHSTRHRLLDDNLDLDPNNKLSPWSAFVDSLLAFVPQFFRNVLCCGVDSYRLARKRVELRGRRERELQMANYNGSSHAMYPVMQDSEPLNGSAPSTDPSYHQYPSASPPTTTLPPSNHQYDGYQEQKNHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJ54</accession>
    <name>A0A8H7UJ54_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Mitochondrial carrier protein LEU5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_006675</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJ54"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002167">
        <property type="entry name" value="GDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00928">
        <property type="entry name" value="GRAVESDC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="40"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="139"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="278"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2183667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="41157" checksum="DBE0462C4B8F2D2B" modified="2022-01-19" version="1">MAQLSSNMSVQQETTAHRLQSSAVDQREQPTTKRDTKNLDYVLRSGLAGGIAGCMAKTVIAPMDRVKILFQARNPIFEKYAGTWTGVFKAGRDIIKTSGVSGLFQGHSVTLLRIFPYAAIKFVAYEQYKSFLMPTRAQETHVRQFMAGSLAGVTSVLFTYPLELVRVRLAYEVHHTGKERPSLRLTCSQIYNERAALQQRGISWRILNFYRGFLPTMAGMIPYAGVSFFSYYGLTNFARYNPLATQYTLTPLDFDPNASDLTQKQQLHLRKPKLKTWAELLCGGLAGVIAQTSSYPLEVIRRRMQVGGLMNPNAFVSFWDTVLDIHRVKGLKGFYVGLSIGYLKVMPMTAVSYAVYERMKAHLGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJC7</accession>
    <name>A0A8H7UJC7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EB1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_006868</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJC7"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1430:FF:000005">
        <property type="entry name" value="Eb1, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036133">
        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03271">
        <property type="entry name" value="EB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140612">
        <property type="entry name" value="EB1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51230">
        <property type="entry name" value="EB1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EB1 C-terminal" evidence="7">
        <location>
            <begin position="134"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="86"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2181943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="235" mass="26224" checksum="E1AD604EEAC0F930" modified="2022-01-19" version="1">MDSIFGDVGMSKVKFDTKQEYEYVANFKVLQHTFDKHKIDKIIPVDRLMKCRFQDNLEFMQWVKRFWDANFPGGAYDALARRKARGTTSRAPTATGTRRPPTQTAAARSASRTATGRMSSAGRQSSSSASAHVLDNHSAAMIIDLNKQIAELKVTVDGLEKERDFYFGKLRDIEILIQEQLESITGDDAPEGVVLKDIQGILYNTEDGFEVPPEGEDHELIASSIPAADSEDETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJU7</accession>
    <name>A0A8H7UJU7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_002247</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJU7"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="69"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2185810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="563" mass="62194" checksum="4E822231E2B2AF5C" modified="2022-01-19" version="1">MASTEENIQRSGSGSDAEKPTVEHTNAANTNAVDGDNINHVEHGQRTVEDMEGAGGLKGLIANPFVFATAVFASLGGLLFGYDQGVISGVLVMPHFMSTFPLNPTEKGFVVAILELGCWAGAWSAGYFADKIGRKFTIVLGTIIFLLGASLQAGAQTIGFLFGGRFVCGLSIGILSMVVPLYQSEISPPEIRGSLVALQQFAITVGILISFWIDYGTSTIDSDVQWRLPLALQLIIGLILGFGILFFPYSPRWLMAQNRETEALKVLTRLRRLPPDHPLVQEEWKEIKAIVEFDRQVERDRYPQYANGGSRARFMIGLGGYRDLFRKGIFKRLWLGCTLQFFQQFTGINAIIYYAPTIFQSIGLSGTSVPLLATGIVGVVNVVCTIPAVLFVDQFGRRKTLLCGAFFMAISHIIIAIIVGLFENDWPAHTTEGWVAVAFVYFFIGWVYPSEIFPLRIRAKAMSVTTSANWMCNFIIGLITPPMIASLHFGTYVFFAAFTVMMFFWVLFFVPETKGRSLEDMDVVFGDKSAVHDAELMQHIQAQVHENDAPPAEAVKQERSDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UMX8</accession>
    <name>A0A8H7UMX8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_000617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UMX8"/>
    <dbReference type="OrthoDB" id="274765at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2184704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="67" mass="7601" checksum="C0D4E9386DDF5DFB" modified="2022-01-19" version="1">MLRRSLYARRIMVSPTLNRSQVTKAASDNNVAVTVNEHTFNMPFNPGQDEPEWANAWRDAVLKVGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCD7</accession>
    <name>A0A8H7PCD7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCD7"/>
    <dbReference type="OrthoDB" id="2366767at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="135" mass="15232" checksum="A71198B344E21AB3" modified="2022-01-19" version="1">MEDIQPTKTVRFSTEKEEIIYTYSPTDYDRSGIHCVPVLYTVNPIIYETKKLSVSIPENSCSSTASSPTESEVSSPEYDTRETFTRIKKGGPKLKIDTSVCRGPLFFTRLSTNPSKSSLPKFDDDDNQFLVPLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCT8</accession>
    <name>A0A8H7PCT8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_008265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07102">
        <property type="entry name" value="ALDH_EDX86601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="857"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="614"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="655"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1075"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="619"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1099"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1136"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1173"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1233"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1256"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1280"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1346"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1384"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2171539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1395" mass="155210" checksum="A2F5E542EC076CAB" modified="2022-01-19" version="1">MSTISVISPATQQPVAQIACLSNNEIDNVVQKAVGAFRTWRKVPVEQKVAIIDKFLKLFPTKQDAISHSIASQMGRPAKYGAGEVKGVLERASYMNKVAVESLKDEQFTDQQGFTRFLRKEAMGPMLIIAAWNYPYLTMVNNVIPALLAGNTVLLKQSPQTPLCADIFAQTLHEAGIPQDVLQVTHVDDQGANYLVQHPQIKFVNFTGSIEIGKKIRKAISDSGKLIGSAMELGGKDPAYVCHDSDVDYAVENIVDGAFFNSGQCCCAIERCYVQDTIYDDFVAKAVALTEKYTLGNPSDPDVSLGPMANVRFADKVREQIGDAVSKGAKTLIDTGKLFTADKAGTAYVGPQILVNVDHSMKVMQDETFGPVLAIMKVQSDQEAVQLMNDSRYGLTASIWTKDVERALTIGDQIETGTWFMNRCDYIDPGLCWVGAKESGLGFSMSHHGFDQFVRPKSFHLKLAQNIALQTENAEHEIFTHYCSPVPSSHRIAAEEQYQQALMRIIAIPVDSENETFDQFRQVHTTVRRATDEFRDSADKQAQCRRELVQVMKAQLASMMEMRENHERYRKTVKNALKDSNAAYIAYRTRDVPKLRKAYEQKCLELDTAQRMSLQEQMQPPPASLAATPPPLQQQHSTSSLGSAAPPAQLLLQQPYKSPNDHSYLDEPQPNQRRSEDTDESSLSSLDANSPQPQKRMAGLMAKMAHMGTQLANAAAAASAPDVSKQNVKNAKTKKDIVDLDTEYRDGIRFLEFLRKKQTDTTSFSLKGFIQRLQSMLREKSVQVKVALDMILKVERKGLQQSQIFVQQATQVAELIHGDKDIEQFRNEFKRDEFAIPSSIFYHNYYAGESKDLLFGISLVEYANAHRRTVPLIVVKCIEAIERLGGTKREGIYRISGRQSNVEKLRQSFEKDEEAVVLNDTAFDVFTIANVLKHFLRELDTPLFQLNMDDRIYHSNIKDTRLRIFNLYKYILNLQKVHYDTLKVLIEHLAKVAANADINKMNIQNLSLIFTPVIFHDHNQAQNPGEWFSDCVLEDLIMHQEKLFSTVDPAAFNNTVAVEDQRRLIEHSNARKFATAPARGYGKDSSLGGAAPSPYPGQLQRQPSGHLQRQPSVGQMGPQMNMPSNVYQQQPPPSSGYLQQNSSGQFVPQLNPTSSAYQQQQQQPPQQPPPHSTQATPAVQTAQAPRLPDIPKNSPFLESAALRTPTDPEPDHDRFAQAIAAANEATSQKITPLPSPSGYPGTDHPPPPRPTIQTGSSSLSVNSPQPGQFKPLPQAAASPVRTSSRTSLMQLPGSYQQQRQSPAIHTSPATPAAEPDHLESPLHDVLAADSYESPLGSWFDDEEETKADIKEEPKEKRISLSALKRTMSLRKPSSVPKLPPTDAEPARRSDSLPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD58</accession>
    <name>A0A8H7PD58_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cysteine-rich transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_008115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CYSTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD58"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028144">
        <property type="entry name" value="CYSTM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12734">
        <property type="entry name" value="CYSTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cysteine-rich transmembrane" evidence="5">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2171735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="77" mass="8758" checksum="6C22FA2F8C3E435A" modified="2022-01-19" version="1">MFSNKQQQQYPQQQYSQQQGYGYPPPQQGYYPPPPQQGYYQQQGPPPQRRDNSGFMGCLVGLLACCACEECLDLVCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDE0</accession>
    <name>A0A8H7PDE0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_002938</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDE0"/>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000003">
        <property type="entry name" value="60S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018256">
        <property type="entry name" value="Ribosomal_eL13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01104">
        <property type="entry name" value="RIBOSOMAL_L13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2171316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="211" mass="24060" checksum="1A31D7B7546A4F4A" modified="2022-01-19" version="1">MVLKHNNQLPNQHFRKDWQRRVKTWFDQPGRKKSRRIARIQKAARIAPRPVDGLLRPAVRCPTVKYNTKLRAGRGFTLEELKEAGINRKQALTVGISVDHRRRNKSQESLELNVQRLKAYQAKLIVFPRKAGKAKKGDAEASELSNATQFKGAVLPIEQVVAGEEARAIKEEEKNGSAYKKLRYARSTARTLGAREKRARDKAEEEAAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDL6</accession>
    <name>A0A8H7PDL6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific]</fullName>
            <ecNumber evidence="5">2.5.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_001451</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.87" evidence="5"/>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDL6"/>
    <dbReference type="OrthoDB" id="19639at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038887">
        <property type="entry name" value="Nus1/NgBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528:SF0">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2171975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="267" mass="30163" checksum="6A835C7B4813ACA2" modified="2022-01-19" version="1">MSSAKLQKRSQAANIKPPEFQVRSGPAPNLGAEQSTWLVTLIRKFILSCLLYAVSLWTLAKAASSRSWFFILKHTLMRNVTECIVRDKARLTKIPQHLAIIVANEQTWRGRSAQQWNSIIQDICNTCVWSSEVGIHTVSVFESSGFLKRRSAQVQKQLVKAFEDWQLLYANSVGSTRPVAQYKGFKLSIFAVEDGKAHVAQVAKQMAIAVTESGRFRADEINISLVDKWMTESIAEPELALICYGSAHRYIELGGFLPWHMRLTEFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDM4</accession>
    <name>A0A8H7PDM4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_001438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDM4"/>
    <dbReference type="OrthoDB" id="2307294at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2171962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="152" mass="17036" checksum="4E5F276174261FCE" modified="2022-01-19" version="1">MNSQISTDYLNFNRSDDNLTHLDTGSNFNGFPTCGDDGLALTLPESYSHVKSSPYLVNLFTTHDMACYLAHVSFTDDIYTLPMSLQKLLNEAKEEVVLSQSSPAYLPEHRALDRLNQVRDHLLHASCGDVSVLVEHLHKPWSDDLLEQLCGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PE54</accession>
    <name>A0A8H7PE54_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_004829</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PE54"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF87">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="58"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2172287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="600" mass="65001" checksum="E9F96460EE0BC636" modified="2022-01-19" version="1">MSDSDIKHSVDPQEPYMTEKIHPVEAIDNGAQQQELSSGVSKIEAAQAVWGKKGYIFLLVGLGLASYIYSLDGVTTYQYLSYATSSVLDHSMTGAVTTAGAIIIAVGKPFMAKLADYIGRGETYIVVVIFYVVGYILYASANDINQIAGGQIIYSFGYTGLQMLTQIVLADVTTLRYRAFAGAVLSMPFVINTWISAEIAEGVLSGGGWRWGYGMFAILVPVCLAPVIGSLLWAQRKAKKLNVLHLTSDPNKNLFKHPLKAISIANKEMDVPGLILIAAALALILLPLGLAPTASNGWNTPSMIAMIVVGCLLLPVFAVWECVFTSRFGYTAIAPLRFFKNLNIAAACFIGFFDFVSFYLQYTYQYSFVYVVKTEWSFRDLTYFSSTQTIALCVFGLLAGVILIWFRRPKWLLFAGLLIRLLGVGLMIQSRGALGSDVELVWCQILQGMGGGFASVITQLIAQALVSHADVAVVTALVLLLTEIGNSVGSAIATAVWTSQMPSELAAHVPTTNATLLAELYGSVTTIATYPAGDPIRDGVINAYSNVMRNLCIGATVVAIFPPIIAFFFVSDITLDNKQNKLDDRDLTGHKDNEKPVEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PE62</accession>
    <name>A0A8H7PE62_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Triosephosphate isomerase</fullName>
            <ecNumber evidence="6 11">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_001492</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="6 11"/>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PE62"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000025">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF41">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2172015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="253" mass="27948" checksum="3B71930CD10B0167" modified="2022-01-19" version="1" fragment="single">VIIFHNMTRQFFVGGNWKMNGSVSQVKDLVELLNKATVPSNTEVVVAPPAIYIDRVRQALKKDIEVAAQNCYYKASGAFTGEISPEQLKDMGINWVIIGHSERREIFKESDEFVGEKTAYALQAGLGVIACIGEKLEERESGRTEEVCFRQLKAIAKYVKDWSKVVVAYEPVWAIGTGKVATPEQAQDTHAALRKWLKENVSDQVAEQTRILYGGSVNGKNAAELGKKEDIDGFLVGGASLKPEFADIIVARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PED2</accession>
    <name>A0A8H7PED2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_004924</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PED2"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2172382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="58415" checksum="0CB87AC6F4C89C5E" modified="2022-01-19" version="1">MVDRLPEGFIRTFLEENVKYSPAVIAVATGYFVASRLYRVYLGPTSVIPGNFIDNFFNLPLIYYNLPLGKRYKNFIDLHQKYGPVVRVSSQAISVADKHMIKQILHDDDLPKGRNYKAFQFEGHQTLFSTIDKDFHKTRRRVVSPAFSVKYLSALEMYMSAEVDVLNDHIRSAIKSAKQLGTEPAEVDMWQLLQRTALDVIGTTAFDQSFEMVKGGQHPLPKAISDDLSMSALRASTAGLPIISNIIDLYLKYQKSKQFDISKFMIKIIEERLKSGKRKNDILQILIDTQKAELKNDRLDNQDIVQENILFLIAGSETTSNTIGFAITHLIEYPEVLRLLREELDDLYPRDVKADMKHEDLKNLPYLNAVLNETMRLKPVAMGGLVRETPSNYLLGGKYHIPKNMLLSCAIYSCQVNPEYWPEPMAFKPERWLEDSDIPADKDAFFPFSVGSRNCIGKNFAWMEMRLILASFVYNFDIAPVPESIEGLNDLRQFVTYTIASNSYKVKVSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEE6</accession>
    <name>A0A8H7PEE6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Molybdenum cofactor biosynthesis protein 1</fullName>
            <ecNumber evidence="6">4.1.99.22</ecNumber>
            <ecNumber evidence="7">4.6.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">INT43_004933</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>GTP + AH2 + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + A + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Isoform MOCS1A and isoform MOCS1B probably form a heterooligomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the MoaC family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="6"/>
    <dbReference type="EC" id="4.6.1.17" evidence="7"/>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEE6"/>
    <dbReference type="OrthoDB" id="429626at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21117">
        <property type="entry name" value="Twitch_MoaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000117">
        <property type="entry name" value="molybdenum cofactor biosynthesis protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_B">
        <property type="entry name" value="MoaA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040064">
        <property type="entry name" value="MoaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="MoaA_twitch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050105">
        <property type="entry name" value="MoCo_biosynth_MoaA/MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960:SF0">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01383">
        <property type="entry name" value="cyclic_pyranopterin_phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01386">
        <property type="entry name" value="main_SPASM_domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="21">
        <location>
            <begin position="73"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00054222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00063038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAG2172391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="396" mass="44418" checksum="92DCDA3EFD8244A3" modified="2022-01-19" version="1">MLKHAQCRVPNLIARNGVRLNHSAAAAAISHSARVSEHTSSPSEELRSDCFTPQEKIDEIDANRPFSNFLTDTFSRQHNYLRISITEKCNLRCTYCMPAEGVQLSASDKLLSTDEILRLARLFVSEGVTKIRLTGGEPTVRPDIIELVQGIGELKQHGLINLGMTSNGIALKRKLPKLVDAGMDSLNVSLDTLDKDMFEMITRRKGFERVLESVHQALDLGMPSVKINCVVIRGINDREVSNFVALTKDLPLTVRFIEYMPFDGNRWNVEKLVPYKEMIQDIESRFGKFEKETDDPNDTTKAYRLPGYAGKVGFITSMSDHFCGTCNRLRITTDGNLKVCLFGPAEVSLRDHMRQSTNDQELCEIIGMAVKKKKKQHAGMFELAAQKNRPMILIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEG3</accession>
    <name>A0A8H7PEG3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_004935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEG3"/>
    <dbReference type="OrthoDB" id="10265903at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_bL36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_bL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_bL36_sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052010">
        <property type="entry name" value="Ribosomal_LSU_bL36"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18804">
        <property type="entry name" value="RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18804:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="Ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2172393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="81" mass="9057" checksum="DFE107D21BEE62B0" modified="2022-01-19" version="1">MSLLQQWAKVMSRQIASPAMARPLLQSNIQMSAVSPSLTLIRTMKVRASVKKICDGCSTVKRRGKVFVVCSKNKKHKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PG40</accession>
    <name>A0A8H7PG40_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_004592</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PG40"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034821124" description="SH3 domain-containing protein" evidence="5">
        <location>
            <begin position="32"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="329"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="462"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2173218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="560" mass="61276" checksum="F54F4D83B8A7FBC9" modified="2022-01-19" version="1">MHCTIKHHLPTVMLATVVMLAAAWLPSLITAQDPSCMNLQDSQACSAYQQYYVDMPINTTYFPWADSVTDVTSFDQAIFAYANSTSLYLQPLGCNNGAYISFVPYARYSASMLCEQIIQDSLECNALNHLFPAPLCSDTCLSYVASVAQITSNTTLCQQSDQRTSGIADLTNRCSTWVGLNGTTNNSCISGSDNEEANCGFQNDTITACTFCKTNSSNSCCSSISGCNYQHLSAGAISGIVIGSVVAAVLVAIAIYFCFCRRRKPFQKESKLTSYVPQPFQNRNQRSFNVLRSGSRQSLVANSSYDPHSNSITSVIPEEANGLTDFTHEIEEFYVAMHPYPPQIVDELELHAGDVVCLAMIFDDGWGLGFNVNTGLKGAFPLVCVTPASREVLEQVLMGEDAQHSQKTLDDVDDYSDAAAFGSYMPDSRTTNTNLGIMNLPDEKPQDKLELNMERIRETLRRSISLSQTSRPVSSQTMASSLSHSNTIPKRTASIRSAHTGSAPASPTTPTSPNSPLFGMTPLSNALLRSRNHQEDDTYEMLSQRRQQRSASIGTNSWTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PG98</accession>
    <name>A0A8H7PG98_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_004477</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PG98"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000320">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000314">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="15">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="756"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="653"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="653"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="791"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2173104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1018" mass="114557" checksum="298BB0AF1A8EE8BA" modified="2022-01-19" version="1" fragment="single">PQYGVAKLGHEDYFSQSPLKTQSEPPPAKDDNLDHSNDEADDEDVIYQPKGLIRLREESGAVTPSRSRVHRKSGQDIARFTDESLHSFGFTPPCRDQNMFEARRNVVNRSLDFMKKLKDKVDMAKLEPYAGTGLDAFAKPIIDLKHEALQSSSFSRAHRRQTAVPYSEASQHVSEAILTNRRMSMDVNAQLDSTSQSHCQVHPPTRFLPQNQSIITTNEVGKILLFNDIASLCFGYDKSYVGQSILNVFEENTKAKLEGLLASRIAEVDQITEQDRGTVLICGKVLPIIRRNRTKTAASLWLKQKLDVTGNTIYIWIFEEIAESLVTMQLTSTGDIMKVTGAINDLYGYSEESLIGKKIDTLIPACCKLRSGDSGFYDNKDAPAVNFNELNKFKFYGSCTSFGARFPVIVKAQPSENPCSPNGLSMFDLKIVSIPTIAGLVNVRLDGSIHSINSVPAKYLFGYSPEALVDKKNVGELLPQWSKIFNGLEKRNLLRKSSITDYPSCRRILLDQETSTRVTKVGSIQQMNVPHNRKPTTVLDRQLPVIHAVHRDGTRFEVQIQLRMMDIAEEELIALWITFDRVSTFSKYGHMNKLAANNVQLASPISNYPHMRTSISTPSESALLTTHGHKKDLDDSSFSSKTVAPIHVESAATTLQSTSPEQTVTTVPRPGPRSFGVSSFGSPNIDKKVMPVQGSMLVTPHPSVDMVKAAPSPSPPPKPFRLPSNVMPMTPPPARTPPISLLNYSALTRKTTISDYCILDSLGQGAYGMVKLAYRLDDPEKKKVVIKYVVKSRILVDSWIREIGKDRHLRMVPLEIHILHTLRRIPHVNCCHMFDYFEDDDYYYIVMDLHGEGLDLFDYIELNRDMGEQEVKSIFRQIAESVRHLHHNKMVHRDIKDENVILDENGTALLIDFGSANYVKEGKRFDTFSGTLDYCAPEILQGQPYEGPPQDIWSLGILLYTMVFKENPFYNIDEILARELRIPYEFCEGAIDLIKSMLNREVDKRPTIDAVLNHAWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PH24</accession>
    <name>A0A8H7PH24_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_004519</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PH24"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="42"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2173146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="494" mass="54887" checksum="4050B5CF53ACEFAF" modified="2022-01-19" version="1">MSVRKDELEPVEHVAQHSEIDALANELGIDEKKLMRKIDWHVLPVLCGFYLLQAIDKGNIGLAKLGGIQEDTHTSGSLFNWAVSMFYLGYVVAEIPCNLALQRINPRWWISSIGLGWGIVVCLMALTNSFATLAVARCFLGVFEAGVLPASVLITALWYKRSEHALRTAIWFSCSSLGSAVGGLISYGIQSHLTNTTVRPWQWLMIIEGLATVAWAFVSFVICPNVPEKANFLTENERVFILNRQRLDKTQTKLSFDRQQAIEAVTDYKTWFLFCIYLIWQAVNIAFSTFNPSIIAGLGYSNLNAQLLSAPFNIFNLIIQLAISWSSDRFNDRSLHLIVCGLLAIVGYACIVAIPTTSDNSGLLYGLLFFTSFNSGSLTLILGWMTNIIIGHTKRVVASSIIIIGSSIGGFVGSLVYQDGSYGRGHIINLTLISAALIMAAVLRVLLMWENRRRDKQAEADPTSYGQDDTLVEDPDIIVKENFTDKDPRVRYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHR6</accession>
    <name>A0A8H7PHR6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_004258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHR6"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052246">
        <property type="entry name" value="Cell_Polariz_PKAAnc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155">
        <property type="entry name" value="A-KINASE ANCHOR PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="200"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2174237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="398" mass="44921" checksum="EDD6C420D04AF7B0" modified="2022-01-19" version="1">MNASAAELEAGHTVSDPAQSEKAALPQSYYDTTGLPTLQQVLSRKTLPPVCLYNFYIIMRDRLHSEELLDFYLDVQHHEILWRRYVKTMRRSGQIEEADLSEGLHGPKLVSRLSYASIRRDDSARSPSPSGSRSLEAGNNSSTHHLVHEDDFTSEDAHRQYKRSSSPSPMVPRGPLTETTYPDNHDSAVASNIHGHTNPSPTREEVKASCEKIYYKYIVQSAHKEIFILPAAVRRDIAKRIEQDERDDPAVFAEAKDLVFDSMQCKAFPKFLRCKVWGNTTMWQQLARLVLGLAALFIGFAVELSLILLDRPQWGERFWGLFPILFGVTNVLTGLTGLDPVWALVFNISETTTLHFNKVRQPQVRKVLKSRAAWLSTLSIILSVVITVIFAAIPGHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PI17</accession>
    <name>A0A8H7PI17_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hyaluronan synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_004415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PI17"/>
    <dbReference type="OrthoDB" id="9876900at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050501">
        <property type="term" value="F:hyaluronan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085029">
        <property type="term" value="P:extracellular matrix assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030213">
        <property type="term" value="P:hyaluronan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913">
        <property type="entry name" value="HYALURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913:SF12">
        <property type="entry name" value="MANNURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2174392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="61357" checksum="1B5B4A66B4D13142" modified="2022-01-19" version="1">MKWSIPPKIVYSICVSLIFVLPALIGYALRIRVFKASYLAIGVYGLVVLIFIVLQLVFATLNRIIAIRFRRKTKQVDSEKTPECYKVGLAVVGYRESPELFSQCLMSIKQLEYPHPLKIVAVIDGDEQEDYEMAHIFEKEFQDSEVTAIPYLLSEATEQQKLDFTELCKSSAQISCYVQPHRGKRHAMYTAFRFLLNSDCEAVMTTDSDTKFDSKAIMELERALHWYGNIGASAGDVRIWNTGNLLSFMASLRYWMAFNIERAAQSFNRCVTCVSGPMGMYKASALEEVLEKWIKQSFLGMECTYGDDRHLTNCVLQKGHQVVYTHLAFCETETPEKFLRWFKQQTRWSKSFYRELLWNAKSIHKHSPWMAAELFYQGLYPFILLFSIFFTLWSRIPLALAAWLISLVAIGSIKTLYALVVSRDFKFLLFPIYSLYYLLGLVPAKLWALVSMWDVGWGTSARSASELKKESQILLKLKEALPVIFWWLLILCGVVFNIIMFTLHPPPLPYDVSSPTTIVFYPNPDQIGAESFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PI18</accession>
    <name>A0A8H7PI18_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PI18"/>
    <dbReference type="OrthoDB" id="10398566at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2174434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="110" mass="12360" checksum="F266B3B052B67214" modified="2022-01-19" version="1">MVSIPEPQVIALPPIELQDTKHDFEQDMTDRKDSHMAIRISATPEYNKGSRFQEEGDSLLNNRVDDDTEPSTERPSVLRSKKFLIISLTIAAILIIAAIALVVWVEKDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJ13</accession>
    <name>A0A8H7PJ13_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_005949</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJ13"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008603">
        <property type="entry name" value="DCTN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034">
        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05502">
        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="SET" evidence="15">
        <location>
            <begin position="488"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="556"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1011"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="563"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1017"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2174887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1115" mass="127032" checksum="62B91F46BF43BE8B" modified="2022-01-19" version="1">MHALERNTYVISGTQSSTINRCQQQVCARNCFQCPTCQNTLNVVANQDAISRDTTSTETQDKPPVNPYHLFCGVCRWDSQEIGVTFEKPTSLALQLQKSEEARPDIKEFEHLKEHFEKFLRYNTPQTLPTSFLSLSSSGSFSKMGYNSSTMGRKTNQAKMDDVGDYKPSEHTPHDDLAVMDNLINLQEDTKISSLEQRFNQIYDQPYDTSKIRPQRIHLRIKRSKRCRTCRHILIKPEQKAQATRFKIKLVAMNYIPNITLQMLPRKTLPLRQNLPTQLILKFINPLYEEISITLATPQQNDANQEESSAQPWGKVTLLSPHFTVGAYNETIEYDDELLYGKPSALTTTTTTAWENGVYEKRNNYTSILIEVVPEYEGEFKFPLLVSYSYKSDEDSLESPDYDNDDDADEGKTQKRSQTLGGASEDRIKTYSFWCVVGLGELRFLETAFLVLGYIVASRGTQQDGMYQSTNVRDYEVKTVVNQETFVNFLEFTNFGNVGHSLVAKVDLKAGTQILVEKPILSYALDPKCCSSTSPYYSKKIWKALCDVVRQKELEQAGHQSDADEDSDYDSDDEDENEKPASLFCPGVPAAMIAYLSIAPPPHLMQRKSPWMCEKSDLGFYYAPDVEEWNDHPTVELIRYTVETACQTIPEFGHINPLDLISFVLKIYSNAHTVAHENNRTLTTHTKRKQRREYYRKKQEVYGSPLMTTSWPSDPESRVLSKIALLPWGSKFAHSCSPNLFLRYDPAEGTMIFTLIRDLKAGELLTFSYLPEDDSSLGGLLCGTTESRRKKTWNFKFFHCACERCTDWDWARGIECQKCSSSLCFKEGGDQPDQERDWHCFDCKAKYATDQVDFVASGREHNIQQIAVAFGGDIKGTPNQSMLRMMEPYLLSLLDPSTDPYDSDGELREDLPAPVPKSHWTYAYLHYLLSAYHLRLFGAYFGKGLSKSLGMYAKGFEEASIYVNWLQNNLWLAPNHSNVLTQNASGNKMAAFFAGWQILESCIDVLFDETSPKSPEEVDDLSGVDSSDDEDELEKKTSKLAIDGQASQPISPPMYLEHCVTMADIVESHWLPLITKVLPQTNDSHNQEKVQDTMINKMTRFIIQTRQLQQLNNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKE2</accession>
    <name>A0A8H7PKE2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_001188</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKE2"/>
    <dbReference type="OrthoDB" id="2271790at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="250"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2175541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="296" mass="33001" checksum="A0D253F0B4982136" modified="2022-01-19" version="1">MPSFFFKGDSGNSSNTIVDPSQTLLFEAQQEFINHRYDKAIPILEKAANQGSIRAAMHLASMAMREEHRRVCADCQVAAAWYIKALNLLTARAPNIPCTTESLELIEQVVELLMSHMLKDIGSKEGRTLTNILWSMGKDLKPRAAIKLGSSDVAKMTESDQMQVCYARAMCITIYNCRGFIYQAERNNEKAKHYYTKCVNVPATDIHSCDVAQKSAELSLGYLDRDSITSCSPLLTPSSPTSSIHSAHNCSGCGVEKAMMPVCSRCKVRRYCSNKCRLDHATEHEQECVTLRESRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKW8</accession>
    <name>A0A8H7PKW8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKW8"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="188" mass="21078" checksum="7449C420A45860F1" modified="2022-01-19" version="1">MAEQAQFSCAKRVAGVKPWQKSGDPNRNCSPGSVTSGPKGIQPACHKRQCNNLSWQPWSPEHYFIMNRDEVSYSACIAFQDRRFILDFSHDIFSYVELPLCINASHNMFLVVLPLLVCQRADFPTSDRKKPPKEKAGYDTIVMGSRFETGISSSGSENYGQFTSAPTTNGNRKRFSQAQKITKRAGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMM0</accession>
    <name>A0A8H7PMM0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_005458</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMM0"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="151"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="141"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2176224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="281" mass="32130" checksum="93A123C2FEC6D2DE" modified="2022-01-19" version="1">MTTIVEREMFEPMSFTNVFEDNHLHTPTRFLLNCLSDSFTPSFGTNYGFEETNPFEHSFNTEKHNQQPHVELVTGKPSSPGYPSPVVTPPSEPLPINDEPAIPTVPAKTTVFKSQGPENFETPKGSRGSPKYKTLKHRLVVEEENDEEDLEVKRLKFLERNRQAALKCRQKKKVWEQELQERSELVQQRNKELRATVQELKEEALALKNQLLAHTECDCTLIRDYLTKSEAFKLFSPTSYSTMPDATTNMHMITSRSPSLQLSPESMVAAQDYSIFSDSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNJ2</accession>
    <name>A0A8H7PNJ2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNJ2"/>
    <dbReference type="OrthoDB" id="10321148at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="51328" checksum="3232C995438D6169" modified="2022-01-19" version="1">MVFIARGNGVFQLKMPTVLVLIALFKTISAIGTSERPTYASDQPLLQPSASDWMLLWTRILTQYVLWWLTDLLIIVVWKRKSWKIWIHKAMRKILLQWRPGIMFIITCEPKQAVDAYKLLGDDGGPITNTSLAITLLVDLFTIAGGAMSLYKVWNHETIGNGWSIMNLFFAPVPPAIISFFSTLTVIFNTRNRTRIILIILGLVAWPAIMLPLLSTHISLKGMKDDYWVFELVSWMFSMNPFVIIRMEHVIVLFIAFQRLFEILVFVGSDPTTSRFPFPALNTWAFGAPLLIFGLGIVIFAEVALFTVYKNIIFYYTKLKARWSNALFHRKNGTEPPPLALPMHTVPNDILTVREIVPTLPDEPFEKEKARKTAKSQTMATPAATQSQALVLSSRQTQTLRQNQPSPPISRQIEGVGQAPASIATQIRGPDIDPIWNLMFAQRQADGSRPNDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPI0</accession>
    <name>A0A8H7PPI0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Extracellular metalloproteinase</fullName>
            <ecNumber evidence="13">3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fungalysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_003272</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase M36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="13"/>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPI0"/>
    <dbReference type="OrthoDB" id="3227768at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09596">
        <property type="entry name" value="M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050371">
        <property type="entry name" value="Fungal_virulence_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478:SF1">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034469640" description="Extracellular metalloproteinase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="FTP" evidence="14">
        <location>
            <begin position="85"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="513"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2178019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="743" mass="82052" checksum="7546A712CC2B9B57" modified="2022-01-19" version="1">MKCSIVSAVLLLASTATFSSAFPTNAREPVNSRVSLDNFGPMLHHRTYETGSSTLSPSSFTNPLNADPKEIAVHFAEESLGAGKYIIKNSYTSEHNGVTHVYLRQLHDDLEVVNGDININVDRFGRIISYGDSFYRGKAHTLKAAQVAESQFKDMTYRNSILGRIQHGANIVSSTVNQKVFGVEKPQDFVPSSTNEALNDFHRASPDASVMSPVQALQALAHFIRPVLKDDSVLSSLGPEELAITTSSSFQAGEPELHIHNVPFALAPVPARQAYVQLDNGELQLVWDLQIEMEDNWFHGQVNAHDGSVVALMDWVSDATHYRVFPFGVNDPSEGGQKLLTDPHDPISSPEGWQVQTNIRGQSTVFNETVGNNVYAHENFEGGNSWKNNQRPKGVVQKDGSLSFDYEARVDIDEPKTYIHAAVTNLFYLNNMIHDLFFRYGFNEVAGNFQEENVKGGKGGDAVIANAQDGSGYNNANFATPPDGQHGKMRMYVWNTVSPMRDGDLEAGIVIHEYAHGISTRLTGGPANSGCLGWGEAGGMGEGWGDFFATMIRMNETHNRDSIFGMGDWANGGDGIRRYKYSTSMDVNPSTYKIMDKPGYWGVHAKGEVWAEMLYEVAWDLIDKHGFTSSLFPPTTTAANKDKKKKDPSDIDEATKLHILSHGNTLVFQLVVDGLKLQPCRPSFMDSRDAIIEADKQLTGGENVCLIWKAFARRGLGTDARYDGNDWMGVRTESYEVPKQCKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQ93</accession>
    <name>A0A8H7PQ93_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_003485</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQ93"/>
    <dbReference type="OrthoDB" id="2417221at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16465">
        <property type="entry name" value="NUCLEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16465:SF0">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="9">
        <location>
            <begin position="5"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2178232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="16230" checksum="9AED2272EB427C00" modified="2022-01-19" version="1">MRSRYYCDYCDCTFPDNATNRKNHIDGAVHQQNRQRYYAQHRSLEEVIEESRTKPPCRQFMRDQSCAYGANCKYSHIMFDRYTGNPIVPDEIQSRQKSSQRVRYELPKNWNKKDLSPSLLPPPRKGYDWSNVGQWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PR54</accession>
    <name>A0A8H7PR54_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asteroid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003513</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asteroid family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PR54"/>
    <dbReference type="OrthoDB" id="25987at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026832">
        <property type="entry name" value="Asteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039436">
        <property type="entry name" value="Asteroid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12813">
        <property type="entry name" value="XPG_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asteroid" evidence="3">
        <location>
            <begin position="155"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2178260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="677" mass="76602" checksum="AC6F54C61AD737AD" modified="2022-01-19" version="1">MGVLGLAGYVADLPSLGEKIFWKPGSTSGAKFFIDGNAYVHHLYVNSNLDWIYGGQYAELATMFMNQIKAMQSAGIEVKFFFDGPLHSRKEHTRMLRNRGNIDRIKGALKNMAWLARKDTNSEPRSTAEISQHLFVIPPLALDVCVQALRHDSIEFQFCDGEADGEVARQARKVKGYAVSRDSDFFVYNLEDAAYIPLDMLTILPDGVSAMAYHTSKIATHFALEMRFMPVFASIMGNDYLSGDLFRAAVRRHVETVDTQVSKSWFKRTASFVNYHAKQSKSMEDMLFCIVNAIPDLPEHITRQELLQTMQESIRQYDYPQSDSDATQSAKIELPSGSKTFWSATSDRFRNGRYSFKILDVVQSQKFWCIPFVEDLDRESSWMISRQLRQWMYSIVLIPAEQHSSLVSITEYVRHAHHVGQDIVDTMDISEIASLAKLDAVNRSNISAFENSLPLFLRLHQCNPENMLSQSLQPSILSLIAILRYLIHNAASPFGDHQIVQKFSNHEIVAIIVSTITSLASILWPDQPTLTLNLSASLPTRRGLEIAAQLQTTLISSYLLAQALDLDDYLYPPPSLSQYFNGQSLHYYLRNAKGGATIERMVGKRPVISSLCHQVLDIVMAGWQENEVEIIFQYNQKSSERKKNPNSEANNRKVLKKKAKTTGSDNMFNVLSSGCRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PR81</accession>
    <name>A0A8H7PR81_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003277</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PR81"/>
    <dbReference type="OrthoDB" id="2429134at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="6">
        <location>
            <begin position="272"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="352"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2178024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="417" mass="45918" checksum="B97831FD6990B6B1" modified="2022-01-19" version="1">MTASPTATDGFRRRSGSSPLLPPLATLYHSHEPHSALSDTKHRSHSIENHIAANESARKPSEKLASCTGPEIRSREHTVDGEYLWDHPNTGYKRKWSESNSLSPRQSYGLQKSDIDAIIECTTVISNSLAPNMKTNTSMHPLPRSMPSSPVASTISAEERSIIGPNEQFLGLEEGDLDRLVSKATQVVDIFEKAKKRLNSSPNSINSAYISSPSNSDQPMLQNETLEELAEISSQRRAIAMAGARSKPDLGTSSISMFRYADHSKKKHKRAGTEKLQCHSCKSTETPEWRKGPMGPRTLCNACGLIWAKLARKKTQLGDRYKWAAGDSPQARFSGLEDQIFQHTSDLNILNTQLNPTSPIPSTVDKALSSNLPDGHSGSQSRTISSSIGNTSPKQHENTTTNQHTRTDKFKLSFLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRK3</accession>
    <name>A0A8H7PRK3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_002024</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRK3"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034850155" description="FAS1 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="742"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="19"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="150"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="289"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="430"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="582"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2179174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="784" mass="87091" checksum="ACEBBA5754249415" modified="2022-01-19" version="1">MKLLILLAILVEVFPIFALKTIVDVLQGDSRFKTLVGHVKRTGLDTRLDELSKGTLFAPTNDAFDGKKDTISRDELLYHLTGAEWHAKELFNGQILESMYVREDYLGEQGQRLVVKSNGKKSDTYINDAKVVDADIKAGNGVIHAIDGVLKPPIEALGSVDDLKDFNEIIKKAGETDLLNRPHPFTVFAPKGEILGEFSDIEKCYLLSHEGQQDLASIIERHIHDGAIYFMELIDRNESLSSLQGERIGVEAKDKDTLYVDGNKVTEKDFLAANGVIHEIDQVIVPKALKFNLRKTLIGMNATKFVKLLEEAGLDKYLEDDSKSYTILAPLNEALDLDEVPRKYLNAWLSYHIVEGQWNPENLTDGQLLKTESKSDKLNGKKQRVKVQVEDSAVIKGHKSINFGRSGVAQDPITSGKHVIYLLSRSLQLPQDMIYSLPIDLDLSTLVATIYATDSQDLINEAQGITLFAPSNAAFERLGLVTKYLLLPEEESQKKLQTLISFHATKSVFYTGRMRTGAISSQTLAGADITVNKTDDGDVFVRGIGAKDGADRGVVAKVFQADNLVANGVMHKIDRVEIPHNIEISAKNILRGIESSTFIAIMQHANLSDIIESDKKYTLLVPNDRAFARINISALLRDQERLDRVARLHVLTEPIQNGNPDTLFGDDADYPTLLSGDDRIRIKEESDNNYAVEVKGAWGGDGSSARVLGYGRTTDGGGVIQVDTVLVPKNDESFTPSQGLRWWQILLIVIGSIIGLMLLVVLIFYGWKWWQNRREGYIALGDNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRM0</accession>
    <name>A0A8H7PRM0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRM0"/>
    <dbReference type="OrthoDB" id="2320408at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2178249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="277" mass="32469" checksum="4A8906185A472372" modified="2022-01-19" version="1">MYTLAHMPYDILVVICSYLSPFDRIYISKTCKSLYSYRLDYSMMNNRIVLSGLSTSHLVTDQFFAHLIDTMTQRQRDHVELIDFEFASQITVHSVMMALTTFPNLRTLNCRYCRNIKLPDLSSSLQTSVVKPNRLEKLYLGDWKMPISREWDDAWMAIDKRLKEITQSSTVVETSDCRRCHVRQTPLSRACCQCKQRIWHCQKPACYAWWSTQQCPTCNVLLCHDCRFKNTQRGTCTCEDMDLEQRDECRITSCVRHGHRQNHISARPDMYCLQSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRY9</accession>
    <name>A0A8H7PRY9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRY9"/>
    <dbReference type="OrthoDB" id="5575722at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2178798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="563" mass="64289" checksum="D27ABDA87FECCF7F" modified="2022-01-19" version="1">MSKLKQLADLMTININDRGSSQISEMQAETIRLNKINADTEKRRDLAKSDWEDREQQLSEQLQRLDTYQKQMQEEQRGETTTSTLLRHLMSDNIPMSQLEKYYLKRLDSLDSFWHESLDVLMFASSNGDTAYSEMKEQDFPLNKLSEMWLQAEQALNSVKQEALEDRSFDSRNKVMKWAKQQAAQYSRHALKAQALKNRLCRSQSCQIPDNGGGESSMNGAKRSFETMDSSLSPTVLQMPSLKRARSTTNRIQDIRDLVGKCVQEKLQESEIRKIHAGRPQQHLQRSQVSMELPKLSKDLMYEHADMDEDIISPLSKIAKPEVMYDRNGRRIRRASEDEYQVSPPKVPSPRQQSKKSNQTKSTLSSTTPKLDRLFKENRGGKVDAAQPNKSDNKSTGLTPMEIAHEKILEQMNNPPSSMITPPRSHTRSSTTHYHSSKFETPSIKDFSMYKKKLSEAADIEGVHHTLSLSRVSPQQDHFLHNAEDEEDEEDIFQDLVLNVPQSTPQRPITRDIRGDLEHTMRYAASPANTSLVAYNAVIDEASVCLFGENMPDNFDDGGDMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PS14</accession>
    <name>A0A8H7PS14_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_001998</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PS14"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000196">
        <property type="entry name" value="Cell division control 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="49"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="378"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="378"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2179148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="426" mass="49662" checksum="33ACD6F987A4046C" modified="2022-01-19" version="1" fragment="single">LALPAEQPNFEHQSAPSPQPISNVVRKKLQGYVGFANLPNQVHRKSVKKGFQFTCMVVGESGLGKSTLINTLFNTQMYPGKYNDEAPIEPPKTVEIQSITADLEENGVKLRLNVVDTPGFGDFVNNEESWRPILDNIEARFDMYLEQENRVNRLKIIDNRIHACIYFIAPTGHALKQVDIEFMRRLHTRVNLIPVIAKSDTMTEEEVLAFKERILSDINFHNIQIYQAPQYEYDDAETIAENREIISKIPFAVVGSDREIEAEGGRKVRGRSYPWGVVEVDNEDQCDFVKLRQMLIRTHMEELKEHTDNVHYEYYRTEKLTAMGIQQDPTVFKEVSPMQKMEEERLQHEHKLQKMEAEMRMVFQAKVQEKEAKLKQSEEELYARHREMKDALEKQRMDLEERKKRLESGRPMTPEKSKKKGFSFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PS62</accession>
    <name>A0A8H7PS62_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003514</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PS62"/>
    <dbReference type="OrthoDB" id="2018906at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.600">
        <property type="entry name" value="Domain of unknown function DUF1214, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1610">
        <property type="entry name" value="Domain of unknown function DUF1254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010621">
        <property type="entry name" value="DUF1214"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037049">
        <property type="entry name" value="DUF1214_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010679">
        <property type="entry name" value="DUF1254"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037050">
        <property type="entry name" value="DUF1254_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36509">
        <property type="entry name" value="BLL3101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36509:SF2">
        <property type="entry name" value="BLL3101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06742">
        <property type="entry name" value="DUF1214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06863">
        <property type="entry name" value="DUF1254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160935">
        <property type="entry name" value="VPA0735-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034165902" evidence="1">
        <location>
            <begin position="21"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1254" evidence="3">
        <location>
            <begin position="65"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1214" evidence="2">
        <location>
            <begin position="334"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2178261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="463" mass="50185" checksum="F6BA189A81520479" modified="2022-01-19" version="1">MRALSFGLLATAVSLGNVLGSAINDCAQVANSSIDLYTYTFPLVLMQATSNQTAQDGLSGVITQDPSNHLVVKINLDTSYVQGFFNLEKYSYTLTVPNHGSRYWIAQYLDAYSNTFADPGNRTLEDKPYTFGLIGPKGHRNFLPKNATVYESPTDMAWILGRVYQNGTTTDQEIVTDLIKQWVVTKYPLHSSKPISVTSTPIANGTAPSGSVAPLAAVTSLTTQEFFDTASQLMCDNQPAHADKKFLQKMSKDLGFKPCSKEAFKKPNFVYSCLLPNFTTTAVKTIAAEGVASAAAIMHDGWPVYTSGIGAYGTNFIFRAVVALVGLGANLAEDAVYPSATKTAAGVPLNTSQAYTLTFQKGDFPPVDAFWSITYYNAQNYLQPNTANVYALRSADPFTYNSNGSLTIFVQANAPSNSSFSKNWLPSQSNGTFTLTLRLYNPQQAILNGSWVPPPIIQSAQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSS5</accession>
    <name>A0A8H7PSS5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_002080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSS5"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="16"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="61"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2179230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="61294" checksum="EFB2DEE631595613" modified="2022-01-19" version="1">MHTVQWQALQAHLRAHHLELADDPKKYRKVLALNAMKRGSVAIESHALAFVPLPSVRAEICNYCFKRATRATPLQRCSRCQSAYYCSKHCFQKAWFAAHQYVCKANQPSATQEDQDKMDELMLERVILSIARAKNDITHNAADLALGAHLEAFSSLLAHETKQPQDQLDRFKHIATAVIQKPHIKSLGIDAAALLIYLCRFRSNNFGIIDNQLFPIGEGTYPIGSLFNHSCRPNAVALYNGTSQIIRLIDDVEEGEEITLAYIDVANSRKTRQQMLRDKYFFECECTRCSSDHGFGLVDQLLGEPSEEEDVYVEGGETFLKKTLMEQVESWNVLELTKRYPPGSDATVSPGFIMDIPRYVHFMGTFMFPSVANRSLRADGLLEAPKEVYEQLLFNAAAAATSYPLLDETEHGGGVLKPYSLKTLTVATRLLNEQMAKNRWPQSSRLAMLVLTHYMFIYPRNHPMLALHFLTVAKAAWNALVQLEVAGINRKLEKEYERGVSRWIHLAKSTLSCNFGEQGEHWREIVELEWIFNRDQKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSU3</accession>
    <name>A0A8H7PSU3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_002083</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSU3"/>
    <dbReference type="OrthoDB" id="10249245at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2179233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="97" mass="11283" checksum="C7BDFB9A62BE8D65" modified="2022-01-19" version="1" fragment="single">MYLIADDLKEIEVESSAEKAEYSDFLEKLPKDEPRYAIYDFEYEKPGEGLRSKIIFYAWTPDTSKIRSKMLYASSKDALRRKLVGIAIEVQGTDYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PT04</accession>
    <name>A0A8H7PT04_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_002070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PT04"/>
    <dbReference type="OrthoDB" id="2014058at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008699">
        <property type="entry name" value="NDUFB8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05821">
        <property type="entry name" value="NDUF_B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034509461" evidence="3">
        <location>
            <begin position="22"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2179220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="161" mass="18023" checksum="9136AA92BF01B589" modified="2022-01-19" version="1">MAPRIPASLVSSRLLVTRVAATPASLTASRNQSTVHDGHVQKDPQIGEYPNLPHLSAQVRSPFGWDDNQDRRNFEEPVHEQDEVLGVWAPDLHFYSPYKALAQFGAFIGVISAFSYLVYKTNPAPTFIRRTYPYDGLKEELGAREGDIKQRGARTEPAEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTL8</accession>
    <name>A0A8H7PTL8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_003760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTL8"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23279">
        <property type="entry name" value="beta-trefoil_MIR_SDF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46809:SF2">
        <property type="entry name" value="GH21273P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46809">
        <property type="entry name" value="STROMAL CELL-DERIVED FACTOR 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034156892" description="MIR domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="4">
        <location>
            <begin position="28"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="4">
        <location>
            <begin position="90"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2179973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="203" mass="22207" checksum="B17F25F9B762992F" modified="2022-01-19" version="1">MRLYSALILAIVSSALAASDIPELEHGYERVTCGSIIKLTNMDSGHKLHSHNIAYASGSGQQSVTGHPSAVDANSYWRIEASHGRGCYRSEPIPCGAAIRLRHVNTKGYLHSHYHNSPISGQQEVSCFDKEDHGDDWQIVCTGKSKEWMREDGIKLMHVETKKYLSANPKYSFAAPIPGQLEVACSTKDGSSALWAAQASVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PU75</accession>
    <name>A0A8H7PU75_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TATA element modulatory factor 1 TATA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003725</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PU75"/>
    <dbReference type="OrthoDB" id="74178at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052602">
        <property type="entry name" value="Growth_transcription_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022092">
        <property type="entry name" value="TMF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022091">
        <property type="entry name" value="TMF_TATA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515:SF1">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR TMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12329">
        <property type="entry name" value="TMF_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12325">
        <property type="entry name" value="TMF_TATA_bd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA element modulatory factor 1 TATA binding" evidence="6">
        <location>
            <begin position="896"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="TATA element modulatory factor 1 TATA binding" evidence="6">
        <location>
            <begin position="959"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="825"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="865"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="973"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="547"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="825"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="873"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2179938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1039" mass="116132" checksum="1D48748031DA6662" modified="2022-01-19" version="1" fragment="single">AILAGITIALRSPTTAHLGIGSMSFFSGDQKQGNTNAWGGFFKQAISSVETRFDNLLDQDSTGSSTPTKNEINNDEETYTDTYVDPITGMVTSVQRTRPKKSATKVANQPAQTSSASSKVEAKSKVSDSLTNARNSSSDLSARLAAVMADRNSRTPSPSQSGRSTPKPSETSESNRTSATDSKVKEQEITKAENESGAAPKTDEEKGNLKETTSLEGESGATRKTDQDEEKTEATVEQEVEHQQIDVANASVNKEEDSEEVPEATDVQQAEDIPQAEENIDTALSIHKGEENDTGVTEVDTKESILSAADNDRIDAPEKSILDSGVTEIGLEPVLKKDGEEKAAPAREENVKSVVEEITISDLTDKETDTDNADNLLSESPKVDHKVSEEVLQPIITSKDSTDSDEKWNEIIRQREEQVLNVMKANADLHEQMHQQQETSDAEIARLKAKVDELVSAKSGNRLVDDLRSQLAAKDAQLKDLMLEGEALSKRELKHMNALKKLRAEKSESDKSQQELQKKIDKGASDLVEANVKIARMMESEKKNNESMKNYSVNTNKQQKTIAKLEKNLEEVKDELKASQTQVEQLKKELQEIKDSGEKESNAAHAAALEKELKANDRLHKELTEVRSTAEETERKLKQNIRELQVALQTVEEKAGYREDNLRQDIATLQKRLQAAEASYDEVHASMDDSTQPLLRQIEALQAKVNEMMRSRDDMERGLISQLQEAKSLHAQSSANEAQLEKTVAEHRDKATSWQQQIYDLQQKLDMSESELKAQKASSEETLKKLTSLKHDLKQMKQQHVVNLEEERQKSALILKQQLDEAREKWEETSRQERARATSIGSPLGRSKRQNSFVANWVNDNTDESRANRFGYEQSSPVTSNRSSFDSSPHTGPVASSSGPPTVLVERLNATIRQLEGQNQLHQMQAQQSAHSRDELAEELIKLSRDMDELYVYVTRGRVADHHIQHINLISTRREESKAAEQLKNEHEGLNQRYHAALEMLGERTEQVEELKADIADVKEMYRNQIVELVQKIDQLSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PU82</accession>
    <name>A0A8H7PU82_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PU82"/>
    <dbReference type="OrthoDB" id="286814at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF36">
        <property type="entry name" value="PHO85 CYCLIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="36847" checksum="185925EAB3F22CCF" modified="2022-01-19" version="1" fragment="single">IYHSLNDFVQSTHQSGKQVYPVPYKANCTPIAFEQKTATTYQAYGFPPSTAPSLSSSVSTPLSASSVDDEDIPHVITTRISPGYSSDLIERISLVDRLVETTSSVIVAIWGPAMESRSAKVVSTAQFVREILKRSKTTYSTLQAALYYIFRIKASVTEHMVKRQAGPAMEKPNPKDCIFCGRRMFLAALMVASKFLQDRTYRNSAWAKISGLTTAEITFSEMTFLHLIDYQLFISKNTFDRWQHVLSSHINQLMNTLPTSGCLPTNLIPSYRQFIHIDRVDDYTQQRVRSRSSQSIMPERSVDVKPQLKRQALRDLDQPRKKMCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PV36</accession>
    <name>A0A8H7PV36_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_008436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PV36"/>
    <dbReference type="OrthoDB" id="2404679at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034271285" evidence="3">
        <location>
            <begin position="21"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="732"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2180857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="773" mass="85115" checksum="998ECCABA1804559" modified="2022-01-19" version="1">MYIYIAATLYLLCQIGMVIAGCCFQQNAVQPTENTWIVNVTAVDTRYSTIPGSYNTTVLFPSSFNISLDNGLPSNVACQPPLATDNETSIIFCQSTNSESFVAGFVLTSEGNSSTAPAVKSLVIDNSLCSNLTKCNSETALSAGDVQIGSQVYPKWAVALTSVVVAAILLCIGIIIIKICVSRQRNAARLELKTEYSDISRRPTDTSNLSHNEKNLGDQHAYSQPEVGNDIVRYKNGYGKEAYQQLPDIDMPTKSGKLPSSSSFQRLALGSKTLLTSLPSLPSLPKLPSFSTMPLFLSNSSSSQDSSLEEEPFRSKADSSVLLDDFSESSASSSNKNNSTVRSRAAVEAHKVIRRASRKSKTRSTIYTDEHINKIFQLDDGAKHKSMNELYPQYGDIRNKSTTTLCSGINSSTPSSVRVKHRELTVLEGMQAALIERSMSASNVIDQSEDNDSNTEENIAYVASDHEDIRPKIRTRSSSLSQGFSKTYGDFDNMKAKSFEDFHNKSLEFRGRQRRSVCSTDAKRRSQSATPSASSTIRPRSFLLPRSIYDEDSSSDDNSDTITRAKFQRRYRSLSRAESQKSYSTRRKSRPTSCMSNTSDVDTIRKHLRDSWKAELSESHSQDSLTVDADLPSAIPRVQRRPPLPEGFMRRRSDRFSRPESIVEPIPEPAPPNDLTSQDSLDTLSSFVPEQGYTSEDTESISYSNVVSLAILHTDTISSGLSVLSNMKGKHETESSIGGVHETNSESNRSVHSAQSFSDLAVGDPRPLAQSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVK5</accession>
    <name>A0A8H7PVK5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVK5"/>
    <dbReference type="OrthoDB" id="2257833at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="185" mass="21747" checksum="918E516126AD1BC1" modified="2022-01-19" version="1">MKLTTSPQDRFNHFNRHVERPVSTYSRNSKSSWTKSRCKSPLTTDLDSKQTQSCLHNKRRRTRPCSQDGLAHRTQHSPALNEDYLLELRRQAFSELHIQTQAYNDTFVARMQHLESLPQEEQRQLWAMLGDHDHNDNHDKDTQAVLEIIDMLDRNSMNDYGAYLERLQALDDPLSSPEHDIGDFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PW43</accession>
    <name>A0A8H7PW43_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_008419</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PW43"/>
    <dbReference type="OrthoDB" id="2098203at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019192">
        <property type="entry name" value="Ribosomal_mL40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042831">
        <property type="entry name" value="Ribosomal_mL40_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39150">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39150:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09812">
        <property type="entry name" value="MRP-L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2180840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="149" mass="17140" checksum="3239A1F0AF89EB48" modified="2022-01-19" version="1">MSLFVRTGRLSLARQQILRAAAPASAPSGGGDQRLEIIRRVLFEQPAKEMPKLEGEALQQHETIERAWKLHQNQERESRNRSLERKFRKMEAAMNELEKTNDRLFKAAIVKSRHITFPRELKMPTETPSPQGWNHEYKPPVDATAPKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWA6</accession>
    <name>A0A8H7PWA6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWA6"/>
    <dbReference type="OrthoDB" id="5819478at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36851:SF1">
        <property type="entry name" value="GLYCO_TRANS_2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36851">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="565"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="2">
        <location>
            <begin position="257"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2181003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="614" mass="69587" checksum="41DD21B67DD42CF8" modified="2022-01-19" version="1">MKKKKKIVKVNTTSAYTLLLLHISASNIMLINYPFELVAPFSAIASVLLLPLGPLLVPRFYLIFLIIYFTFFLYTQINHLFKFYITTRRIKRTIRAWNNSQRLHTSDSTNVSSAAISPAPTPTREGYSLDDEHLVDMEASLRPYEDSQLTHAFIIPNYSEPEALLRDTIKRLANHRNSQNNYVIILAMEDSEVGHMEKAESLQNYFRDSFQHFITTVHPSDIPGEARGKGSNVAYAARVGCSELLKRGVDRRRIILTVSDSDSAIPELYINEVEKAFNKAEDPYFLLFVPPIFFSRNCFEVPAAVRVTDITWSAMVMSNLSSGRGLAFPCSTYSLTMILAEKVGYWDTDADAVGEDLHMWLKCFFKTGGLARTAPIFVPINLTNVQTNGYMANMNARYVQAKRHYNGIADLAYTLRHSAGVRDNSVLDSTGIMLPMTPTTPSFSARSKMSMYVSPTYWIDKMIVCVKVMEAHLIPATSGWLMFAAVPLMQFILFPPSSTFAFVDPDENPILTSEFFSTLWNIVKIITIFLPFPLFGTLAIYEHLHRTVDRELFRKPASESRTLKNVVDFASLPIAAWMFMTIPATIGCIKRLFKTNDQYIVAEKFFSEESESQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXJ0</accession>
    <name>A0A8H7PXJ0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Fumarylacetoacetase</fullName>
            <ecNumber evidence="4 15">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_006871</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="4 15"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXJ0"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.230:FF:000001">
        <property type="entry name" value="Fumarylacetoacetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000004">
        <property type="entry name" value="Fumarylacetoacetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="17">
        <location>
            <begin position="16"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="16">
        <location>
            <begin position="126"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2181946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="420" mass="46022" checksum="6B9F7C6E6CDAC05D" modified="2022-01-19" version="1">MQSFIEVSKESHFPIQNLPFGVFSTADKTSPRVGVAIGQEIVDMSVIQDSGLLSDVSGLQNGVFEQPSLNAFMGLGKPVWTATRRALQTLLSASESRLRDDASLRQRAFVAQKDAKMHLPIAIGDYTDFYCSKEHATNVGIMFRGKDNALQPNWLHIPVGYHGRASSIVPSGTPIRRPCGQRLPGKDQPPIFSKCAKLDYELEMGWVVGTGNELGTSITTADAKEHIFGMVMLNDWSARDIQAWEYVPLGPFLGKNFGTTISNWIVTLDALEPFLVDGPAQEPTPLKYLQESSKSAYDINLEVSLKHSQASSFETIAKSNLKYMYWSITQQLAHHTVNGCNMRVGDLGGTGTISGPTKESFGSLLELTWNGTEDVPLKDGTTRKFLEDGDTLNMTGYCESSEGWRIGFGECVGTILPANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXV7</accession>
    <name>A0A8H7PXV7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXV7"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="421"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2182268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="491" mass="56460" checksum="C8D350B7F67A2011" modified="2022-01-19" version="1">MTRMTTGIIISRILGQHKRFSLHSTGRFATLSRSFATSLPRNDGPLKEKVRAIPFSQHVKAAEQTFENYHGHSFFSAKVSRAGAPDEVFIPFWVVTAKVRSVILQAQIVMVFNVVMFLCSVLTEALLRETHWETEWYWIQTKHSFDREYIPIQHAGLQIYAAHQYRRGYVNGIRGQSIADAAPFTPDMLDRSAYQDLDTDHRSKTRKVDPFTIFPSSAVKLAKKYIQDTEEQLADEYLMKTYRGDRTRLVHVDVQLLDLKLSPVYFPAYVYTINYLGRNFRTFINGDDLAVGGQRLYNWERVALASAAAMGSVMAFSGGVGWGGPIGSLWLGIILPTVATSLFTMYYPLLALRWRDEIRRREIASHAKDEKSWDKDWVSAFDAFEDFQRYRQWQEERAYKRSTFGDQESERINASVRDPKGYYRTLGVSEGATKAEIQGAFRGLAMKHHPDRKTDPKDKEVAKQKFQEISQAYNILRDPKKRQLYDQGANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PY20</accession>
    <name>A0A8H7PY20_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007302</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PY20"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050152">
        <property type="term" value="F:omega-amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000002">
        <property type="entry name" value="Nitrilase family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="29"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2182372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="317" mass="35287" checksum="5D59A62C0AFB96E1" modified="2022-01-19" version="1">MLSAITKRIAPSFSALSRNMSVNVQGSPFKLALIQLAVTDSKEHNLKHAHERVMEASKQGAKVVVLPECFNSPYGTKHFPEYAEDIPEGASITALSAMAKEAKVYLFGGSIPERESSTGKIFNTLTVYNPLGEMIAKHRKVHLFDIDIPNKIRFQESEILTGGSWLTHVDTEYGKFGTAICYDIRFPEIAMIAARKGCIAMIYPGAFNTTTGPLHWELLQRARSAVDNEMYVAACSPARDESTEYHAWGHSTIVDPKGQVLATCEEKEAIIYATIDPQEILDTRKHIPLYGQRRFDVYEDVSQKAEESSDGKITLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PY90</accession>
    <name>A0A8H7PY90_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_006860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PY90"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000289">
        <property type="entry name" value="Acetyl-coenzyme A transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2181935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="61610" checksum="6FA9E2E22A34483C" modified="2022-01-19" version="1">MTTSDVSSRNKLSPDHNGVHHRKPKPDASSMLDPSSDSVHVRKRDHVSVVTDEDRQEMGQSSYATDYKAVDDEKAQTLSATDVPNFILLVILYLLQGIPVGLSFGSIPFLLKAKMSYSEIAIFSLSSWPYSLKLLWSPIVDAIYWPELGRRKSWIIPIQTLTGMLFLALGWHIDAIMAEDNINIYFITSLFLVTIFFCATQDIAVDGWALTLLSKDSLSYASTAQTIGLNTGYFLSFTVFLALNSEEFSNKYLRSPENSSDVGVMPLGSYMIFWSLMYIVVTAWLLIVKTEKPTGTDEDLLGIKGVYSTIWKICKLPHMKSFVAILLVAKIGFICNEGVTALKLLEKGFSKEDLALAALLDFPFQLFFGYYAAKWSTGPNPLKPWLYAFYGRLASAVLGMVVVYFYPEGQDISMVYFCIIMASTILSSFMSTVQFVSISAFMTSVADPLIGGTYMTLLNTFSNFGGTWPKFFVLEAVDKFTVATCSALDGDGLELKLGGTCVIQQDGYYYAGSICVILGIGLLVFYVKPAILRIQSIPRHMWKLKAAEDEKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYG5</accession>
    <name>A0A8H7PYG5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007513</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYG5"/>
    <dbReference type="OrthoDB" id="5344169at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00083">
        <property type="entry name" value="bHLH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="410"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2182582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="509" mass="56875" checksum="AEF0D968E57A4505" modified="2022-01-19" version="1">MSGSSPRLVMDQRDRMNQAINDLFNADSNMEYFTIPADKDDMSPVLESLDTSRKDHHGSDLYKMVDDYEHHFHVSHQSHSISLSLTPAVTSFDLMDQNEKWQVISSHTRESTPLVSPAITPSVTYRNQAIDGSSNENYENIANDVFSSDDLELTPLSSPAIIPQMGSEAKRGHLDNFDAVERHLESLEQAKSLVKKQLADLKHRQYGAHQKQQSLDTIETLAQEKGLQQLERNTRAIRKTSRTRASHSPYENVNKQRKAAVEASIKSPTTASDSLPTSMPPPTTSPKGNSWSMLDNGPHHSASTAVKSSDDVKPATPSSIMNIRTKSRSNSSRSSSVSDFKPVTTKIASSKPSPRALRPLLVSPTLDVYSSIEDAAKALEAKSNYQNLREGKTDVLGIKFSPGINAGLENRRSAHKKAEKRRRDSLKDWFNKLREEISVEMEECMDLDDDNSTETSSQEPGQDKVLSKLSVLSRTCDYMKRLKTELKRRDDYIADLEQKLNSTEAVNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYI1</accession>
    <name>A0A8H7PYI1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_006997</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYI1"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="157"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2182070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="322" mass="37172" checksum="71BEA57CF32E9F9B" modified="2022-01-19" version="1">MNSTIVVDSSQIASPRVLPFMSDSALALVAPLVVYWVYSLFFHFLSKAEIPFVERYRIHDPEDMKRNKVSVQEVIRGVIFQQVLQTVLGFIVLEDESSSAATFLTTENITSVVSNFLRIMSVKPYIVEQYGMPVYIDVLATISSLLQYYLLPAFQFFIAMFILDGYQYFFHRLFHQNKFLYKHIHSHHHRLYVPYAFGALYNHPVEGFVMDSVGATLAFTLSGLPTRGAIVFFSFSTLKTVDDHCGYAFPYDPFQFLFGNNVAYHDIHHQPFGIKKNYSQPFFTWWDRLLNTYVSTDRVYQNVSAKAQIKGKIQHTEAIVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYM2</accession>
    <name>A0A8H7PYM2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_007130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYM2"/>
    <dbReference type="OrthoDB" id="2414662at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000024">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="35"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2182203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="426" mass="47687" checksum="FE4DB2819F9D26B9" modified="2022-01-19" version="1">MSNNTTKPIIGPSEKVAHFEKDVWSIFTPLAAETKAINLGQGFMNFNPPDFVQDAANGAISDVAANQYSHPKGRPRLRKALADSYSPLFGRELDPENEIIVTAGANEGMFATFAGFLDEGSEVICMEPFFDQYISNITMNGGVPVYVPLRAPAKAANENISSHEWKLDINELRSKITDKTRMIVINTPHNPIGKVFDEEELIEIGKVAEEHNLLILSDEVYDRLYYEPAKQVRIATLKDFWKRTITVGSGGKSFAATGWRVGWLIGPSELIQYSLAAHTRVVFCVNSPCQEALAIGLEKTNQIPYFQNQIEAYTKKRQILSSVFEELGLPYTVPDGSYFILVNTTKVQFPQDYPFPAVLDSRAKDFKLCYWLAKEIGVVAIPPSEFYSKENRELAADFARFAFCKSDDVLEDAVKALRKLAPYIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYX3</accession>
    <name>A0A8H7PYX3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC3/GANP/THP3 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYX3"/>
    <dbReference type="OrthoDB" id="199574at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF4">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="2">
        <location>
            <begin position="183"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2182440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="433" mass="49069" checksum="E44F7AF22A8E0018" modified="2022-01-19" version="1">MSGFQPSYVAVGPKKAKRARIRLGQFETDELDDKSFPADLREYVKSVYQYCLPDKRKFVEAELKSTIQNAIEDASLYSTDWNEVPLPSGCTSKVNPKSTKSKSFNTPKVKNAGIFGIKETATELSKRESRQLRFQSSPKPNTPVSRPKPVKRTLGQGDDDDESNVGVIVGTSTALEKSYLRLTSAADPAMVRPVHILKKTLNLLKKKWRQEENYSYICDQFKSVRQDLTVQRIQNDFTVQVYEIHARIALEKGDLGEYNQCQTQLRELYKKGIPGRENEFIAYRLLYLLYAQNHADINALMRTLTPERKSDPAIAHALMVRSSMATGNYHRFFKLYLQAPNMGGYLMDKFMERERIIALRAICKAFRPMVETSYIIQELALGTQLALFEVLKGHKAFFPVNGGTHLDTKAAMPGLTESTNKYAKVDIKGPLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYY5</accession>
    <name>A0A8H7PYY5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_006289</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYY5"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF26">
        <property type="entry name" value="ZINC FINGER PROTEIN 423 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="131"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="318"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="373"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2183284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="413" mass="46323" checksum="6D5381506995A6E7" modified="2022-01-19" version="1">MRKKSTIILGQQPNKRASPKESARNGKLKEIFSRNRTNFSIHKKKVLDFDVTRNKTLDNLPIADSPKTLRVLENRQCEDNNISIQNCYTSLLSMIDAVYPPLICPTCNATFSSRSEAELHHKTSHQAQARFPCMHPHCDLTFHSRGGLRFHISKCHIVEKIRARPPRNPTLLPHGGPRQGHFVTTAVMTVSNMDASITHVNGSDSVQVTSQTPAIQYNRGFISDKSQSPSSSSNDTSSQGNVEDMGYQVVRDPLQSAKDNTTAITSLMSPDSDTQTFAASNNLPHIKVLQWPTKLPRRRKPNLSAASEVLLNAVYDPLRCPSCMATFPRKTNVIKHLVEHHQGEEPYRCVFQQCNHPKRYATREGLIYHILKSHDEQQDDETESDDARTQTDTEDAENTVSDASHDSSTETDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZ43</accession>
    <name>A0A8H7PZ43_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZ43"/>
    <dbReference type="OrthoDB" id="2290998at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2182545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="562" mass="63330" checksum="A892B88BEBF8A2DE" modified="2022-01-19" version="1">MSHGPPTYNTYPPIPSPTLPSQTQIVSPHAFQPLHPQSRPNGSQHTQGMPQPRQDATTVGVGADMIPGPPPNIYCERCQQARPSDFFEASGALRYNVCSVCRSRDVQRRRNTEIDRYEQASHHYNAQQHQQQPNVPSATSQPQQQQQQQPRPYPTHVQTGYQHLRSHPRLPPQLSPHMHQSQLPLSPMQTQMLPPQPPPLRSQSHMQQSPIPSSPQLRQLPPQQLAPPQNIVQQQNRQQQQQQQQQQQQQQQQQQQQQQQQPTAQQQQSAPPNWMRQQPPQQAPEPVKPSPAPTGRSEAKRPNARANGPQGGTLLNMPSNTHNSSLEVLSPEVFVETLRQSQNFERKQFAIDMAPIIAEAGNEAGFTQLGRAVCDRVLQGTGYNFSLKDKRASTKNPLMVTTLRYYCSQRSDTAKHRKPEHPKASNRYECAGALTIIIDLSKIAGYVTLTHKDPHPPFISPNSNSAEARGQHSSQQLMLAHQRLEDKFEKLKVKALQFADLIEQQKMFHSKQFLNMATDALQPADEMLTACSVFELDPAPKNANKYTTHYHRRANAPNANNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZW4</accession>
    <name>A0A8H7PZW4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_006820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZW4"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034818895" evidence="3">
        <location>
            <begin position="22"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2183809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="187" mass="18172" checksum="8626EF704C51BFC9" modified="2022-01-19" version="1">MVKPYLVILLLALVAFQSANADLLPLLGLGGGDTTTSTSPSPTHAEKPKDKETTKENGGLLGLSLPPVLGGGSSSSASDLLSGLLPTGSSLNTAFPTGAPSGSASSSSSSMSVSMLSSVSSSMPTSTAMASTSMAPPPPASTPVVVLTSTIPPPSATAAASAAQHLVPVPLACLIVAALMAVLATAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q061</accession>
    <name>A0A8H7Q061_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_006665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q061"/>
    <dbReference type="OrthoDB" id="2317955at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050769">
        <property type="entry name" value="NAT_camello-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947">
        <property type="entry name" value="GNAT FAMILY N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947:SF37">
        <property type="entry name" value="LD18367P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="213"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2183657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="378" mass="43103" checksum="69E5A30500126B1E" modified="2022-01-19" version="1">MASTEKEVLQTRPEEDINKDATASEPPKQGGVPHGPDIVLRSFQPADLPYAKHLYYTTYFNLVPGAVKHKLMSPLTLSLYMGAFAYLMSLVPILLAGMNVPSWSYPVLRVFMGLSWTILFFAILFGYTDRKEAVDEIEDAICNDMADIEEYYLGWNKEERVVEDGKDSEKVQTPIGEKKVTFDKNSKAAVEVIKTKKPESERTASHFWVLTINSIPSATVAIDQRLKPVYNDRPQPVPPYKTAGQFLCRRYGFAIPNFLQIDDAPEPKLLFPAHKPNEASLQRLAIQREYQGFGLSTILISRAMMWANEHKLEWVNASINEFQGKAANILKTKHGFKQVSKKRTGWFGQCDIELRCNVQEWMERYADDVKEKHFNGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0D6</accession>
    <name>A0A8H7Q0D6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial</fullName>
            <ecNumber evidence="11">1.14.15.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-methoxy-6-polyprenolphenol 4-hydroxylase</fullName>
            <ecNumber evidence="11">1.14.15.46</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COQ6</name>
        <name evidence="13" type="ORF">INT43_007346</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)phenol + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81183"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="EC" id="1.14.15.46"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81195"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="1.14.15.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.45" evidence="11"/>
    <dbReference type="EC" id="1.14.15.46" evidence="11"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0D6"/>
    <dbReference type="OrthoDB" id="683240at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120538">
        <property type="term" value="F:2-methoxy-6-polyprenolphenol 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106364">
        <property type="term" value="F:4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000021">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03193">
        <property type="entry name" value="COQ6_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000689">
        <property type="entry name" value="UbQ_mOase_COQ6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01989">
        <property type="entry name" value="COQ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="3 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="67"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="377"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2182416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="538" mass="59255" checksum="5BE6306B45824A4D" modified="2022-01-19" version="1">MAARGIRTVLCMSLQRQLLKRATLESSRQLRQITRLHTGNITKQAHSVTASQTSAPIRTQNAVEDIYDVVIVGGGVAGTALACSLASKPDFQSKKIALIEAFDLAPVKDWVPSEEIYSNRVVSLTPASVDLLKDMGAWKHLHEDRIKGYHDMQVWDAVSDARVKFNTSMLDGGLHDQPIAWMIENVHLQNGILQSVKEHRLGGANIEILEKTKVEKILYEPIDVGQAQQMDLSDWPAISLSNGRTLKARLLVGADGANSPVRSFAGINSLGWDYDTHAVVATLEMDKSRSNDTAWQRFLPTGPIAILPLKDGTSSMVWSTKPHLAAAIKALPEEAFCDLVNAALRLSVADIKYLYKEMIENKESFSNIITEELEWRETAGQKSMTMTENSINEAALPPRITGVQKDSRAGFPLRLRNAERYIADRIALVGDAAHTIHPLAGQGLNQGLLDIQKLSEVLETGLRNGEDLGHIHLLSNYASNRYGRNVAMLSACDKIHRLFGTEFEPIVLARSFGFQAVNASESIKAEIMKYAMGLEKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0F6</accession>
    <name>A0A8H7Q0F6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_006254</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0F6"/>
    <dbReference type="OrthoDB" id="252020at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481:SF0">
        <property type="entry name" value="LD23870P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481">
        <property type="entry name" value="RIBONUCLEIC ACID BINDING PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="75"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="20"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2183250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="274" mass="30610" checksum="E59605DF32DC52C3" modified="2022-01-19" version="1">MTWSHKSEFGHLLQLFKDDHSSSELKNSLGTTEWSNQVEERVGRSRSRTPRSRSRSPASRSRSPPGRGRGDRNGHWVSISNLTRNVTLEHVKEIFGQYGEILKSDFPFNNKLNCNRGVSYLEFGDRSEAEKAIAHMDKGQLDGKVLVVVFGEPPRQRSPSPRPERRRRFLHRPTDVVRPRHPTDTAALLIITGADDIHDPDRHHHLVVEDDSRIPEVAAPAIHAVDLDHIVIVVVAAVVTIPEAVAEAILEVGAQAIHEAEAHRAADAKLSLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0P3</accession>
    <name>A0A8H7Q0P3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0P3"/>
    <dbReference type="OrthoDB" id="10012223at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF2">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2183223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="317" mass="35625" checksum="329471F446B916D3" modified="2022-01-19" version="1">MPAPAASYPIAGVFYFIAHPQLWLKVICPFLLIVLVGILSLVLSFVFLLPLQAHALIVANCPAWLAWTVSVIFVLLESTVIDLLAFAIITPIYIDILFDKTLKIRGMRRMFDTRAKVHNAVICCRGVTAGVFMLWFLLLAQVSETNFKDKFVDAIADFARFHVSGASLVDNSTIASDSYLWNCGCMLRQRLGSMVSIHTVKIWGHHIHYDLEFRGWSVAESRRYAWKRKSDYAHFGAVAVGLELVPIFNLLFMWTNAVGAALWVADQYEERERITKSQTPSTEGLLSENPYDARSPPTTSASATTLYPDESTYLVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1H0</accession>
    <name>A0A8H7Q1H0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_000592</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1H0"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2184679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="258" mass="28370" checksum="49746DBD3EE22D01" modified="2022-01-19" version="1">MPYSLRPSHVLAGTMIIFGIFSVSVAAAKNATTLIVTVKVSAYYSFSAVAGALGGLIAYSTFSNLQNVYGMSSWQWLFLIEGIPTIFIGLLSFAMLPDYPSTASTKWLTTEEKVLCVERMNVNLEKKDVSFDYKQFKAGMKDYKNWMTALISLGLHVPLSSLLFFMPTFVKSMGFSALTSQLMTIPPYAFAFVAIIVASRTADITMQRGYHIFVLSITAAFGYILVFIPSLWAKYCGTILATMGVYGALPIVGQAFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1J5</accession>
    <name>A0A8H7Q1J5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_006666</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1J5"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000983">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2183658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="178" mass="20349" checksum="1BE96A6967187A18" modified="2022-01-19" version="1">MPATLYLTLSPTNWHIRYVPTVFENYIVNVRLDNGKMVELALWDTAGQEDYDRLRPLSYPETDVILMCFAIDQPTSFSNIQDRWLPEVTHFCENIPKLLVGMKIDLRNNSNRVAQLNAVGHNLISYEEGETLGREIGAKYYECSAMENTNVSETIQAATRAAMTGNMRRLQKKICTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1Z3</accession>
    <name>A0A8H7Q1Z3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Endonuclease III homolog</fullName>
            <ecNumber evidence="14">3.2.2.-</ecNumber>
            <ecNumber evidence="14">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="14">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NTH1</name>
        <name evidence="16" type="ORF">INT43_000352</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="14"/>
    <dbReference type="EC" id="4.2.99.18" evidence="14"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1Z3"/>
    <dbReference type="OrthoDB" id="2099276at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000003">
        <property type="entry name" value="Endonuclease III homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000005">
        <property type="entry name" value="Endonuclease III-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HhH-GPD" evidence="15">
        <location>
            <begin position="129"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2184443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="640" mass="70853" checksum="2B9AE64160B4DEF3" modified="2022-01-19" version="1">MATKRQSARLSEKVSIKTPAAPLSLSSHLAKYKNDIPVKDPPVSEAVTTTTTAEVTTARKVKAAGARKVKKELSEPIEPPKNWKPVYEAIREYRKTSLAPVDTMGCERLGDVKADDKTFRFQTLVSLMLSSQTRDPITAAAMQNLQARLPGGLTLDSILLCNKDLLHDCIKAVGFHTRKTEYIKATAIVLKEKFDGDIPDTIEGLISLPGVGPKMGYLAMQIAWNKNAGIGVDVHVHRISNRLGWVNTATKTPEDTRKDLEAWLPKENWKEINYLLVGFGQTTCLPRGPKCNICPVNDVCPSAVIKAVKKKRKVSVSVDTADSGLHNNVKKEKTEESLECANLHTADQLNMDNPNPESQSTEAQTLEALQQTVQHVENSFSTVFESLSRNFQQNLNMIQGMTSTLEHVLKTGLKVGTKITKSKDPEAAINITLIIRNASQFPMKALAATIAFAPINSHCTGQIEYETQSSVRLLQDSSDPVSSIFSNESELLPGQRYVEVLEVRPTVLAQYNGTIDLGIRSPGTGQRLQVQHKFGVYLIDQLSKSIQLQSQSKFNENDAYIIREYKLSFFRQIMEFSPAQGIAHGTEIKLHAGDTIIECHLLELRVNDTLAKCAFTCTESNDILDTLLSELDLLNNYHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q242</accession>
    <name>A0A8H7Q242_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q242"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF3">
        <property type="entry name" value="CHAIN DEHYDROGENASE (ATSC), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2183649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="29252" checksum="A3AC6B6DEC5AF508" modified="2022-01-19" version="1">MVQVVVTGAGRGIGLEFVNQLSQDSENVVFAVVRNKSKIEYLKPIADERSNVHVVEADVTSPQALEQAAKEIAEITGGSLDWLISNAGGVTDPSITIADPNVSVEKVGQDFLDNYRWNTVSHIYANNIFLPLLRKGKEKKIINISSGIGDEAFTRKSKITINAGYASSKAALNYNVLKYAIELEPEGFTVVALSPGFVDTSKTRDGPVPEGMAKIFGQLLDGFKLAEPEWDGNPITVEDSVTKQIKVIKKLGPKDSGISTSQNDSSEIWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q249</accession>
    <name>A0A8H7Q249_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_000441</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q249"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF5">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="5">
        <location>
            <begin position="116"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2184532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="303" mass="35053" checksum="233C40A9BB20E2A6" modified="2022-01-19" version="1">METEQPSEARDKARLEMDPQRLESIAKRAQEVIQNDQKVVPPFWISKYKKEASRNWDIFYKRNTTKFFKGTCSIFKKVYTRNLSTNDIITDRYWLDREFEELAHKGDESKEKKICLEVGCGVGNFVFPTLAKNPNLFIYACDFSSRAVGMVQANEQYNEARCKAFVADLTVDDLCATVPAESVDLVSAIFVLSAIPPEKMNVAIQNIYKVLKRGGNVLFRDYGLYDEAQIKFSSASDKKLDDNFYVRQDGTMSYFFSLDDVQQRFQAEGFKTIVNEYIYRETTNRKLELAADRIFTQCKFVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q528</accession>
    <name>A0A8H7Q528_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_002471</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q528"/>
    <dbReference type="OrthoDB" id="269518at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23797">
        <property type="entry name" value="UBCc_UBE2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000061">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="3"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2186033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="182" mass="20818" checksum="8558FE0473A60207" modified="2022-01-19" version="1">MSSPRRRIETDVMKLLMSDYEVTLVNDNMQEFYVRFHGPSDTPFNSGVWKVHVELPDQYPYKSPSIGFMNKIFHPNIDELSGSVCLDVINQTWSPMFDMINIFESFLPQLLRYPNPTDPLNGEAAALMMREPATYESKVKEYVSRYATREAADAATDESSEEEEMSDVSYSDSDDEAPGMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5G2</accession>
    <name>A0A8H7Q5G2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="16">1.3.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">2-methyl branched chain acyl-CoA dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">2-methylbutyryl-coenzyme A dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">INT43_002755</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="31">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(2R)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65296"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156439"/>
            <dbReference type="ChEBI" id="CHEBI:156440"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:65297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48256"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:88166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:48257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57336"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:43781"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:44180"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62500"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:44181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:24005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:43465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>valproyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65344"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156457"/>
            <dbReference type="ChEBI" id="CHEBI:156458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:65345"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 27">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Amino-acid degradation; L-isoleucine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 27">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="31">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.5" evidence="16"/>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5G2"/>
    <dbReference type="OrthoDB" id="10262177at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003853">
        <property type="term" value="F:short-chain 2-methyl fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046395">
        <property type="term" value="P:carboxylic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF1">
        <property type="entry name" value="SHORT_BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 27" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7 27" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 27" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="30">
        <location>
            <begin position="27"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="29">
        <location>
            <begin position="142"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="28">
        <location>
            <begin position="248"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00051903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="KAG2186317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="401" mass="44331" checksum="FC2CB26841688236" modified="2022-01-19" version="1">MASFTAKKAFSISAVSRTTPTSLHTFTEDENMLRQSVSDFAQNVLKPLVPEMEEKEQMPKQLIKDLFEYGLMGIETDIELGGSEQSFTAALIAIEELAKVEPGVSAMVDIHNTLCNTIFKKYASKSLCDKYLPQFATKALTSFCLSEAGAGSDAFALQTRAEDKGDHYLLNGTKMWISNSAEADVFIVFANVDPSKGYRGISCFVVEREWGVQIAKKEKKLGLRSSSTCVVNFDDIKVPKENVLGEIGKGYKYAIEMLNEGRIGIAAQMCGLAQGAYNMALPYIFERKQFGKHIGEFQGMQHQYAQIATEIEAARLLTYNAARMKEEGRVFVQEAAMAKLFASQVAEKAASKAIEWMGGIGFTREAGVEKFYRDAKIGAIYEGTSNIQLQTIAKLQAEKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5W9</accession>
    <name>A0A8H7Q5W9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5W9"/>
    <dbReference type="OrthoDB" id="2245455at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37327">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37327:SF1">
        <property type="entry name" value="MICROTUBULE INTERACTING AND TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIT" evidence="2">
        <location>
            <begin position="37"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2185848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="590" mass="65226" checksum="58DA45B20470BF0D" modified="2022-01-19" version="1">MSTEVIRAGAVTPSDGEKYAASEGQPPPSRPSSKAILRKALALANDAVLCDTANNVKGAVEAYTEAVQLLDIVLEQMENETDKMKLREIHATYSERIRLLSKIEPVKGAPTQFKQKSTQDDEATAIRKAPPEIVMQSSTSTPAPTGKSHTNTKRRINQRSMSISDSAINRPSSVFNIPPPPPFQPPAQLKEANIKQPAQELQVPKLTTTARRKVSPTPPDDAPVKTADPSTSGSNKPTIISGIVHQNSDDPVKSLVDALSESPTEIESPVAPPGNNLRQHLSPPPRTHSIISTTLPRARKSSLLSANIYRNHSNASDEGETNATEAFTRLTGQRAPSDIMRMTGPDPTEKFDRSATIKALSLMRSLELSMTVGGHITQRLYVPKNLWYQPNIRLPSLDVKVSVCDSILSALTRLEAWHRLEDVKGALSHLSSLENCLENTQMSLSRKLGMPKITKIDSPSVEQEIYRKEPKDTARKHQSIIAWGNKLSKSVERMNAFNLAKSEDSPRHYVETLVRLFQSVHILDTWLRYYHSMLMDPHQPADKKPQLDALVQKLGKICYLLHTTVCSFVIRDLSIMLGKWVKRGGGWVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q632</accession>
    <name>A0A8H7Q632_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="7">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_002391</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="7"/>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q632"/>
    <dbReference type="OrthoDB" id="3349449at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="172"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="583"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="664"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="601"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="632"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2185953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="707" mass="80767" checksum="8B489C88973D90B2" modified="2022-01-19" version="1">MRLSNNNGYQPLPTFDDNSQSTTIKAWPIARSSSDNTFLPSNSAKSQHSLPYKTKRFIKRRLSAAGLKTRKMSGVSFAPLPATIRDDIDNGELIESEDEKGWIVVKRHRKRKHAYDRGASKARSKRGFKSIFVKHGPLDEQHNQMTWNHLPPLTKEGYMAVIHSVQEAIDQKMYPTRISQGSSGSYFCRDTSGKIVGVFKPKNEEPYGHLNPKWTKWVHRNLFPCCFGRSCLIPNLGYMSEAATSLIDRRLKLNIVPFTDVVHLSSPTFHYDRSDRKASNPQLSSPRPLPSKIGSFQCFLNDFNDAGVFLRNHPFPTDAFYSSSRTVVKKRSLVFNCLGAAEDDDDIDQEMQGRVTQREQGSDKQGFQWTKRLQQQFKREFENLAILDYLIRNTDRGTDNWMIRYCPEADSVRIARGQSSGPVNAYNTTAAVMNADTSIEFSPNEAHIHVAAIDNGLAFPFKHPDKWRSYPYAWLSLPHSLLIQPISVETRQKLLPMLSDPEWWSETVRDLQRLFSLDSDFEPRMFERQLAVMKGQGWNIVQTLLDPSAGILDMVTRQRTVVWEDDLLIEWDQSIIDEREKLRGPLAEHAPPASDRNFPAKSREPEVDADDDGVHSDPEIGPAGSFERASRLESNYTEPSSATDASDQRKRRWNDRLRRSFSLDRVSKHIQPSSPHQEDANASMRQSHITVERIEIVESSNPYFTCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q691</accession>
    <name>A0A8H7Q691_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q691"/>
    <dbReference type="OrthoDB" id="2439595at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2186090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="408" mass="45871" checksum="9F777A90386F6822" modified="2022-01-19" version="1">MSAPVDYQQSPASYAATRPGPMSATENPSNNRNSYSGTNREPVLAPAVPVHQRSTSPTPPGSVDVTSPISSPERVKPKVTFDELKAKYKSLKREKRELEFKTEQLTSQAHRNAATIETLQQQYLESEKLREERDIDYERLQQRLEQVQIRLDSREQEYDRLQANFITHMKAIRATDDDLSTIRTKLANLHGSVAQFSMGLKKHIGDKSKAMKAFARTFPQVDLNGQDQEANIIMHLTEKLVNEALINIYISFGVYPGLSINTAYNELHTWMLNRGADDAALRLKQQLCYIIARDRSPETKSEIAVAHKLLSDQLFTALLEVYPSMESIMRSKIDKFIDKAFDLSLAMRGQEVDVKVLLIKEGDAFDPRTTAADYKGVAEGTVKLVICPPFEAIEGDHGFLLPAKVICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q722</accession>
    <name>A0A8H7Q722_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q722"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="48"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2186304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="201" mass="22785" checksum="7B39563896C57AD0" modified="2022-01-19" version="1">MLFNNDELPQDCHKVCNRILQAFAIALEIKKEEGGKHYFEERHKYDVPCGSILRLLKYPKGGNSEQDEVIRAGSHSDYGSITLLFQHGIPGLEVQASRTNWISAPCIPGAILVNVGDQMEFWTGGRFKSTKHRVVFLPEHAQHDRYSIAYFCHANDQVPLDVIPSMVLENNDINQGQKVKTAGEHLQERLEETYKFSETSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U6X6</accession>
    <name>A0A8H7U6X6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U6X6"/>
    <dbReference type="OrthoDB" id="2275774at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="533" mass="59960" checksum="4464F2B6A7CA73C5" modified="2022-01-19" version="1">MSAQSKITNNGSAEHRRPSISYLYSALPSQIRPDPAAPSTNKIILDYLLYLSIQSRLQQAALELDELASPTPEEKADEPEHIERRANKWRDTASRAERDKNAVESIVAGVLSDHRKRTPSSIATNPQLEQRLHLCQLTNLVFGRFDEEANNNSHAEHTVSARTRKHSMHIVSSISNDDQDESHDVKLRRELFAEPVLPAFCRRHRRTLCALCQAPANPKKRTQQTEPTPQLAKAHGPGLIEAIPAFLKTSADWLRMALDSASNTPAQPMTFAGERVMGGGMPPKWYDLFLELLTQAVIEAYLCDSNVGLEPIFEAFSYGDVEEDEDEEDADESTPHDEHTPDVADPSDVGEQEAEDDEEEELWGVRAEDHFLLFPRTRTIFLFSQQLREREKEFLMVEEGDLRQHFENLAERYPLSEFEKGMGDFIRMVLNSMDSPKLDKYEGSSLSLEKETASENKEKNPASILPAVYQFPSDGALLMPEVPDDDAHKSTAGSSKSTDKPTKTTEDSTDDDARGTKRRHSTVPGDEEAHKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7N8</accession>
    <name>A0A8H7U7N8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_008225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7N8"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2171845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="89" mass="9887" checksum="F9D6D86C48D335E0" modified="2022-01-19" version="1">MAVPTHTGGKLSLPLLALTCKKKDRKAVTTTVDPTSVTVTGNMAVTNLITDTDVMENMGMHRINLNQYNRWFRPSWHPFCSGLVLNNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U866</accession>
    <name>A0A8H7U866_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Plasma membrane ATPase</fullName>
            <ecNumber evidence="13">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_008288</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="13"/>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U866"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000042">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000211">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="654"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="680"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="712"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="749"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="781"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="816"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="20"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2171562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="902" mass="99364" checksum="8C512CEC2416A108" modified="2022-01-19" version="1">MSGTEDPEKKQELVEEQEHHEHEDEISPELEALIQTNPTTGLTSSEVEERLVKFGRNELPEKKTNPFIKFLLYFTGPIAYLIEIACIIAAVVGDWIDFGIILALLLINAFIGFIEEAKAESALDALRQTLALKTRCWRDSQLQEIDVIELVPGDVIVLRLGDIVPADARLLGIGVTGEATEGDLQIDQSALTGESLPVSKNKGSTVYSSSIVKQGQQLAVVTKTGENTFIGRAANLIAITSEEGHFQKIIGKIGNVLIWSTVVLVVIIFVYQMVRFRGTAEGNWKNVLENCLVLTVAAIPVGLPTVMSVTMALGAKQLAKKQVIVKRLTAVEEMASVSVLCSDKTGTLTLNELTFDEPYLEKGYTSDDILLYSYLAAEPGANDPIESAVRKAAENSLPALQSRKEGSHDVPGYKVTSFLPFNPTTKMTQATVANLETQDVFKVAKGAPQVIINLVGGNDDAVRAVNALAKRGLRALGVARTIPGNIEVYQLVGMIALLDPPRPDSGETIRDCNHMGVDVKMITGDQLIIAKEVASRLGMGRVILDANHLVDPSKSEEEVTEHCERADGFAQVIPEHKYRVVELLQKKGFLVGMTGDGVNDAPALKKANVGIAVHGCTDAARSAADIVLLAPGLSTIVDGIKTSRAIFQRLRSYALYRITSTIHFLLFMFIITLVEDWNMPAVLLIMICVLNDAATLVISVDNTQISDRPDKWRIGQLMTLSCLLAICLAALSFATFYVARDVFHVDNDVLHSIMYLHISSAPHFVIFSTRVPGYWWEQPPHWLFTICILGTQVVALFFSVYGIFGPREHVAPCGWPWGLAVLGISLVYFMLLDVIKVWVFRVWNFKLTAFLIPTPARKRKLANRQEDAIKHQEVKESWHKVYKVVETYRVAHAFNRQTTSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9F1</accession>
    <name>A0A8H7U9F1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_007888</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9F1"/>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="321"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="88"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2177231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="851" mass="96827" checksum="B4FF06334544A68C" modified="2022-01-19" version="1">MTDQLPPRRKPRNDLLRNYYGIGGIPAENAADITDIDGSNFDAAKYQSKLLKGKRLDALVNRDNELVTEIRQLNGDMKTLVYENYSKFISATDTIRKMRSNVEDMEKEMDNLRDHMDQVTTKCSEIDSSFSDRREKIRRLDGVHNLLKKLQFIFELPNRLQQCYASGAYPQAVQYCTRTNHLLEHYQHLSVFRNIEMECKEIMGRVQEKVKEAMVQPDATSQTIIENTGLLIQLKEDSTSLSRQYIQLQIEKLKESKYRPSHYLKDSESTPEDLVEKMEQVNMEFLSELEIIVKAYRSFFLPAQPTEDGAKIGMSTTNVSRRSLGSASQKGSISNQEELPSAELSDEERTQAHEQLINSFSPYLEEYFHAVTEMIKIPTEPLDAPRPLTQIRILSCAYSAIMEDSRALCDILLAGERIGRIVEEWESGLLDSLMKGAVAGLQGWILSDKIVANQEEDASVDPGVLTTFVIDTEEWLANFVGMDSLQLLSECLQSGASFVSGKAKKDIFLHQIQSSLLVHWSLIVQSIKQHISNIQAKSSVHQTVCLVASRLCLDFAEIWVIKTYAQFSKELYPNPRRSSNPYRQEEDRDMIVPVLQADVEKSSDLYREAGQSCLVSYARNIGYMLTYKVEDALRDNSWSMATEASKYPVSVSSVWKDIVAELDTIEHIVDIVYPLDHESEERTGSDFSVSRVNKLGSRSPTDLGLTTANQRLGVTSPSMTSLSSFNNEPQFNTSGGHRSFGNDLLSNISKLFQERVEIYGNVEPSSSDICSGLVKVILKAYNEILRELTLTEYAFWQVQIDTEYLRIVLWKFARNEKRDMWQCVSQMHKAIFLGFGGHLQVLDQILRAYEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9I0</accession>
    <name>A0A8H7U9I0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_009135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9I0"/>
    <dbReference type="OrthoDB" id="2317774at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2171474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="59011" checksum="754F8AFAEC638B02" modified="2022-01-19" version="1">MEALPYDLQAYIFCFVNDPYQLSQVNHQFYNITQDPVCIARRLLVLYGRCFESQVLEPVMMPSAKVTQVLLDNGATLPRHFVQKLENGYYEGMLHCTPQSLNVIENRAMDRFGPRFESAEDESQLVTSLLERLEQSEDQHEKDQLNDELYQVLEATDYVPVTLGIKDSDLQLILRLIILAPKAFKLIHHNGFTLRNITRVRDFITLLIKVGHSSYAHQYTIDEITHALQVLYDQCGLDIQPHTINEVFEKITSPEYLGVNRDDGTGTICQVLSKMKFPFELDSLAQQVICRTVRDCGCLFLYETFPCEDAFTEAFLQDFTSRDCSIANALTSHYACRLLDIFGYPHPVTQRSFDIVVHRLVLATFGNEYPLKQKKYRRFSAQFSGQVTNSAAPIDRENRAFHYYLDHSSARLTQNALTFDGREYTGTVDEDNRQAMNIIFDAILKYGVSQWPGVSEADLSNGKVILKLLLDEERKDFAQRNGSASADDAVANQCILSTFHATLEQFYKERIESQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAC5</accession>
    <name>A0A8H7UAC5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAC5"/>
    <dbReference type="OrthoDB" id="76114at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016977">
        <property type="term" value="F:chitosanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.141.10">
        <property type="entry name" value="Chitosanase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.386.10">
        <property type="entry name" value="Chitosanase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000400">
        <property type="entry name" value="Glyco_hydro_46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023099">
        <property type="entry name" value="Glyco_hydro_46_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01374">
        <property type="entry name" value="Glyco_hydro_46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2174247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="377" mass="42320" checksum="9015AA340A104384" modified="2022-01-19" version="1">MSNNSSDSDGSDDQPTEQSYNKTVVYTPNYPIPIPMDDCQKVKIYRLTSLYENSDIYLHFGYCQNLGDGRGYTSGIIGFCTGTGDALQVIQAYNQLVPQPNEFSRYYDTIINLAQNQDDDTSNIPHWCQIWEAVSRDPDNGPLFRQAQMQIADNVDYVPAMNISNNLGLQYAVSRGQMYDALVQHGNDTDPDSILGLLNRTATYFAQNPNATNITTLSNGTKTGPSGSVIKTGQGNQVDEITWLTRFLQVRRADLLNPSDSGTASAWKSTTYRVDSYSYAVSRGDYNWTSNMTFALDNDGQLVNVTCIGGFMASDDTSIPEQLPSESTFNTPLFLEVFIPLMIGLIAIVAFIIWWKCFRRRKWSESKKKGFMSEYWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAF8</accession>
    <name>A0A8H7UAF8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAF8"/>
    <dbReference type="OrthoDB" id="2281294at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2174337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="458" mass="50757" checksum="04495EDA56B6C01B" modified="2022-01-19" version="1">MQCEVRESAELNLHLQSEIVNDEQATLRTNPFISEQSQVKHVATTMVRDEDEDAFYFLTSQQDQLSLSPALSASSTCELDPDNIIDLATRIFYATCHKFTAVAQQPARYSFRQSLLLHSMYSKSQQTLLGLESIRPTVLLSGEDFMFTPPVPAVDWSLNDWALDAEDDSFLEGCHFTTSDGERDQTGIQNNNMVTDFDTYDVVDGDVSEVLIPHSLRVSNADIELEVGNETAKKVLAKELSNWFTTNHTEKVVEPFSDDAQHNIDDDDESIVKIEEIEESESASLSSTCTSSGVEAETNESETSSDKVIEVPTATTPTPEPLASILQELEAHSSALTQLKPNDTMSNEANDLSESMKAPKHIHSSLNNYVSTLQSLVKQKMQDSSVVQTVTANGVRVKTSIGFFTKWMSWLSSIIKVWKLFFLIAESLLVSFGDVILQSIIIHTLGRQLESAPALVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UB36</accession>
    <name>A0A8H7UB36_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AFG1-like ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_006089</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2175027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UB36"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2175027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="56430" checksum="569315E3D1800AA0" modified="2022-01-19" version="1">MKLFVANSAVCRKRLQLTPATKALSLGMTRKCQLYSTTATATAEAEPQTLQDIEKKSTLPATEAKKIEISISQLLCRCHIGPVEMYDQLVKEGKVNSDEHQRNIIAQLQRIWMELKSYHPEAKIESISEKEEQPKGWMSKFSSMVGVKTAAHTSQANDVDAPKSLYIYGDVGTGKTMVMDLFYDTLPIERKRRVHFHAFMLDVHARVHKLKTMEPERADVLGPIASDLAKEAYVLCFDEFQVTDIADAMILRKLITELFARGVVVVTTSNRHPTELYKNGIQRKSFMPCIDLLMEKCEVVCLDSPTDYRKTSREMSKIYFSPLNANTTHTIDQLTKDLTGGKKMTPTVLSFLSRELQIPEQAAGVARMTFDDLCNKPLSAADYLELVKNFHTIVLTDIPRMTMKHRAQARRFITLIDAMYESKTKLIASGETGLLEIFNAEEGTNELNDDFRLMMDDLKLEDVSSPLFNGQEEAFAFQRALSRLIQMQSKEWFTRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBW3</accession>
    <name>A0A8H7UBW3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_004254</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBW3"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="2"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="3">
        <location>
            <begin position="209"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2174233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="837" mass="92712" checksum="A01B7DA2A492A55C" modified="2022-01-19" version="1">MAFSDEQLVQLLELGFDLDTSKAALLNTNTVEEAIDSLLSGRSINKSAVEVHADNNQTQSLETDQRASRGEDAPLITSRYNTTGKEKALRDESLKLAKEMKQHKVMEPESELQAHRRVLEQINEDRERVKSRTHHKVAKLNEHQTPTNSDDVQKSTQKKEKVEEREARKRLLMEIEEDKKSRKLANASRDSLQHNLSSVPIEAATSAPISSQDAFIQFRFPDGRSERSHFPASSTVQDILTNAASKLSVDSNQQDLGSIQMSTLFPRRTYSLADKDLTAEEAGFLPNCTLNITVMPSGDTQINTTDMIVDTDGNRPPSRRGQRSRSTRGRSTRGRRGRGRRGAAVWQGEGRTLTDSTTTENSNAPETSDSGVDDAEQAIARTAIRELRTRLHDTHSAFAAREANTGEEVTTDVKAIKRVVPSLRELCTSAVAVFLASPTKYTTRYLKPLDKISSEIAEHLLEHLIKIRKLDRTVLKRLTAHCYLQSCILNAYPYATDSLLEELCLSASSVSITKLSLSGCDVITNAGIQNLQSLKHLEYLDLSNCKATDKSLSALTKLPALTHLYLATTKITSMGLKLFAEAAQCKESLQTIVVNGCQGINSSDTFCLLANFPHLHQISLASTSLPSPCDIPPPSTFKELDFLDISNTGIGDTEVRRILSSMKALKELKLTGCRPISVPALSFLGRELGNLEELKFPSQNHDLNDCLIHYSRLNLTHLNLGNFKEINDIGMQHISCMQQLRFLSLEGSQITDDGLTLMKEMEHLEQLFLDRTAVTDDGITTISNFPSLIALSLAQTLITDKTLNRIGDPMLTRFTRGLRSLSVAGCNITNKGVRSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UC33</accession>
    <name>A0A8H7UC33_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UC33"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2174428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="559" mass="65309" checksum="88D508602D224632" modified="2022-01-19" version="1">MSHSDSINVHKHKAGTSEGRKPDLQESIKTSLEVGLVDIYGVTVRENTDYLLEIYDRPDDVLKFEDDADYMELYATYRLNKAKRVVVRYILIDGIHYLTRKDCCLQVGEHDNEVTFKEEKPEKQNILEFHATENNTFKILQRNKNIWLTWDKLSINYTGMLFQTNDNGEVYHKPVELLLRKKSIDIRDSIDVLIPEGFDIASIDKCMMDYESNFISYDNEEAISSRLGSNFIVLHNDHFIAYAGKNHVKCDYNCRNRIMKQLCPSKGDEYYAEWIANDCHLKRIDGIIHNTIPPYMLFTNDYVREDDLTSNTIISGYTSLDPQNMVENIKSRSYNYSFFGCYFEEVYSFWLSESLENFGFELPLEQEIGYFLVERLCSSNFNGCLPQLKSDFMTFVNKQQPDPSIRFPEFQLKDIEGLVVEENTDYYLVLYDEDLDVLNLNEYFHNDYLNVSATSNQNHGDILIVQCSIINGIYHLLCNNKYLRLIESEGGHGIGLTDQVPTKEQRLQFQVTKSNTFRTVPWNQRDYLKLNTITNNYGALSFFENGRPLELFLKRVRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UD40</accession>
    <name>A0A8H7UD40_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_007814</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UD40"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15486">
        <property type="entry name" value="ZIP_Sip4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020448">
        <property type="entry name" value="Maltose_ferment_reg_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF78">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00054">
        <property type="entry name" value="FUNGALZNCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="87"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="652"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="734"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="805"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="894"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="837"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2177157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="919" mass="102832" checksum="B5C786AD844DE7E5" modified="2022-01-19" version="1">MSNSGDDMNGKRQRVSRACDLCRRKKVKCDGLIPVCSNCQQFNYLCTYKDTTKKRGPPKGYIEAIENRLYRMEALLEKVASSDSAHSRAAAAELNTPLETPQGETINSRPVRRTASRSESNGNAIPYFPLEHQRESSVSRRFSSPPSQRDNELPPPSSLLMYDDPSVRHESRSNESANGPVGQLSMDETGQMRYIGKSSGLYMIPKLKPLQNGAYFIPRRQLQQRNESEMSVDRQRMLDPYEMPSPDLSEHLIDLYFQHFYPFLPLLHKEKFLAAINGTRGTPPVPPILLNAIYAVASRVSNDPRVRSDPNLAGTAGDIFFERARVLLRDEHDVSKISTIQALLLMSSHQHGAMRSTRAWLYNGMAFRFASDIGLNRNCDDWNIPADVKDERKRVFWCCFVVDRLTSSTYGRSFTIDEADCDINLPDESESSKSSNEAPVIEHFRYLIQLCKILGYIIQNTYYVKARESALSQPVGGIISTLERKLTTWLDSLPPRLQTQPSNNNHHMGLTAPVAQCQLHMFYHAAVVLLYRQMIPAQKLPQDSPQSQGWLRCSWSANAIVDIAQGMLESGKLRHVHNYCIYAIFTSAVIFVHNASSAMDPDLAQESKSSIHKIIRFLQEIEHTWNTAARSCSILSGLLGVREIDLETTQKGFKMESQTTEEELYNTKPGPNTSFERRRGPPQQWLDKRPDDMKTNGFVETPSPQFSPDSYGKPPANMQPRSQLNQEFHRGISSNSDAFTYSPAGSHMGLGQSVDPGTATMDPFAAPGTVLGTSSSNFDPLATAFWGVPSSLDIEEWNSYLGSQGLQQQQQNGPPQPIPMYRTNDTSSPSMAPEPQNPANLPSMRSTDLSADQSSKSLIHTDQNVDILSGISMPQNLPSAPANSTLFNYYNGDQSKTSSYPRGPQDNTANTSTTNMMYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEH1</accession>
    <name>A0A8H7UEH1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid scramblase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003777</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEH1"/>
    <dbReference type="OrthoDB" id="191150at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248:SF9">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2179990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="407" mass="45078" checksum="6585DBE4A979398A" modified="2022-01-19" version="1">MLRTARFIVPALRAYARNDAVKSPKLYSSLSRSRNLGPRQRIQSQAPLTRPHKVATSYAGAQEAQNAAENANTSDTATLVEHDAKLSEDPASVEVTIPTPSDSVIKPDYKGALVLAQPALVVGRQIEMMNVFLGFEQANKYTIMDPNGNHVGFIAEEDSLANSMTRQLLRTHRKFNAVIMNSEGEVVFKITRPYSLINSRIFIRTADDELIGEVQQRWHLLRRKYDLFVGTTQFATIDAPFLGWDFDLRDEQNQLIGNVNRNFVGFARELFTDTGQYVLRMDAVEGSSRGLTLDERAIALACAVSIDFDFFSRHSSHGAGGIMPFPFFGYGGSGEGQQAPTDEAVPPPPSQAGNFPDQYPSSSPPPSQETGYGDVWADESVQSPDDDQPGLFSKLRDMVSDDDQEWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEJ3</accession>
    <name>A0A8H7UEJ3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Saccharopine dehydrogenase [NAD(+), L-lysine-forming]</fullName>
            <shortName evidence="13">SDH</shortName>
            <ecNumber evidence="4 13">1.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">Lysine--2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">INT43_007662</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-saccharopine + NAD(+) + H2O = L-lysine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="EC" id="1.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.7" evidence="4 13"/>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEJ3"/>
    <dbReference type="OrthoDB" id="265306at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004754">
        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd12188">
        <property type="entry name" value="SDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000217">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027281">
        <property type="entry name" value="Lys1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF23">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE [NAD(+), L-LYSINE-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018250">
        <property type="entry name" value="Saccharopine_DH_Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 13" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 13 15" id="KW-0520">NAD</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="18">
        <location>
            <begin position="7"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="17">
        <location>
            <begin position="175"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="202"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="316"/>
            <end position="319"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="204"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR018250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG2177008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="367" mass="40750" checksum="18EBE16572213F33" modified="2022-01-19" version="1">MSAPHLWLRAETKPMEHRAAIAPSTAKSLLDAGFKITVERSSARIFDDKEYEELGCPLVPSLSWKTDAPADAYIVGLKELPENDDSPLHHTHIFFAHCFKNQGGWKEILHRFDQGNGTILDLEFLNDANGRRVAAFGYMAGFTGSAVAIDVWCHQRLNPGTPYPALKPYPNEDALIAHTKSRLDAAAKGGKLPTVMVMGALGRCGSGACDFARKTGIPEENIVKWDINETKKGGPFQEIIDADIFVNCIYLTQKIPPFVTRELLDGQRNLQVICDVSCDTTNPNNPIPVYSINTTFDKPTVPVETSNPQPLDVISIDHLPTLLPRESSDMFSRDLLPTLLELKDRQNARVWTDAEKLFKEKLAASRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UF71</accession>
    <name>A0A8H7UF71_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UF71"/>
    <dbReference type="OrthoDB" id="2407893at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="217" mass="24299" checksum="133C692840381D5B" modified="2022-01-19" version="1">MPNEQSPNLRLSVPQPAVSVKHERALSDSYTPRRCKGYTPIIPRPHSSSSRPNSSLISSIPQPAPYNVRNSGMWPATSDKNRHDYNRLGRELLPPSPDVAKERQRWMKEGGIFQQHRQVSFSETVVVISDGTDAETQNTEVSTLQLATDTKSFSRPQSPPPKQNPKESLSKLPPTVSSEIKADMYDDSQLAMDLAEDIPSQPNLFSKFLTKVSKRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UF92</accession>
    <name>A0A8H7UF92_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_008409</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UF92"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="221"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2180830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="342" mass="37711" checksum="A5215E0ACAEE5557" modified="2022-01-19" version="1">MPPRNESSAVHSCDLCKRKKLTCNGERPCANCFNRNECRYTAERYRPTLLASSNPQSRRLSSGSACETCRRRKTKCDGQQPCNYCSTNGIECLNNSERRKRGLPPVSVIPMKSSASHKREIATTGNQETTGSTFDQHNIGNRDVKMLDAHVNFKNEHARKRALGSPAMDSRASSLSDSTSEFSTFTRQNRSDVDVAHSTTSIKQEPVEKSKAFARCISQSPPSLSPINLASPTSSPPFATSPLPAQSNSGETAYHPVSQISRYHIPPMYNSAPPPSIRARGQRIANMNIQSQEYVDIPTPPTTASPVDIDPMYKRKIPSVMGNYIICLIPSAYLVAVPYNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFG3</accession>
    <name>A0A8H7UFG3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFG3"/>
    <dbReference type="OrthoDB" id="10361662at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="67" mass="7742" checksum="D9B7754EC1922900" modified="2022-01-19" version="1">MSSPHSHHHLHIHHHREDENSHQEGSEDSGVSTYDKIRGTLKEIKGKVSDDPDEYQEGHDIKHPEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFU5</accession>
    <name>A0A8H7UFU5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein light chain roadblock</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_003885</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
            <location evidence="1 10">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GAMAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFU5"/>
    <dbReference type="OrthoDB" id="9985637at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000009">
        <property type="entry name" value="Dynein light chain roadblock"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016561">
        <property type="entry name" value="DYNLRB1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009998">
        <property type="entry name" value="DLC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 10" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="11">
        <location>
            <begin position="9"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR009998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2180097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="102" mass="11458" checksum="3815478C9C00279B" modified="2022-01-19" version="1">MAITQQSDVDETLKRLAGRKGVEGVVILNSDGLAIRSTIEAELTKKYASHVHQLVSHSKDAISGIDSENELTFLRVRTKKHELMIAPDKEYLMIVVQNFHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFZ3</accession>
    <name>A0A8H7UFZ3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">beta-glucosidase</fullName>
            <ecNumber evidence="3 6">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_004036</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3 6"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFZ3"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF3">
        <property type="entry name" value="BETA-GLUCOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="7">
        <location>
            <begin position="416"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2180247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="840" mass="92363" checksum="69D0F755C043950B" modified="2022-01-19" version="1" fragment="single">TISAGQYEPLCFGTRHLLNMVNIDKLLSELTIEEKVSLLAGVDTWCTYPIPRLNIPSAKFSDGPNGARGGDFAASPPAACFPAGVSLGATFDIEIVQQVGAALGEDLKTKSAQFILAPTINLHRTPIGGRNFECYSEDPFLTGAMATAYIKGVQSEGVFATAKHFVCNDTEYQRDSISSDVSERPLRELYFAPFQQAIREANPGCIMTSYNKINNVFAADSKYIIQDVLRGEWKYDGLVVSDWFGTRSVVESVEAGVDLEMPGPTRFRGEKLVAAVKQGKLTEESINERVRKVLELVEKAGKFENPGLAPEQGIDKEEHRNLIRKAGSESLVLLKNDKQTLPLDPSKLKTIAVIGPNAKESIVMGGGSAGVMTHYTITPYDGIKNAVGDNCELPHALGCYTHRFCTLLDGHMKTADGEDGLELEFFNGHGLKEFHSRHQKATSKLWLFDSVPKDIEPAFSARVRTRYTPKTTGKHILGLASCGLSKLYVDGKEIIDNWTSQDGPGIFFDMGSNERRGTCEMQANETVEIVIEFQRAEESRYLAAIRFGLVEEMNPNTIQEAVEIAKKADAVIIVAGLNAEWETEGEDRVSMSLPGEQNELISAVAKVNANTIVVNQSGTPIDMPWVDEVPAILQTWYLGQEAGNAIADVLFGKVNPSGKLPTTFPIRIEDTPAYVNYPGDNGHVNYGEGLYIGYRYYDLRKVPALFPFGHGLSYSSFEYKNVRVNQENIEPEGTITVSVDVTNTSTVDGKEVVQVYVHDKASSLSRPLKELRNFKKTNIPAGETVTVDVVLDKYALGFYDDKEKTWVAEEGAFEALVGSSSTNIHGKAEFNLTSTFKWIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGC2</accession>
    <name>A0A8H7UGC2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003462</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGC2"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF54">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2178209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="374" mass="42013" checksum="77973780BA3D24F6" modified="2022-01-19" version="1">MTTDLSHLQITPESSQEGNEKATGQDVDKIFEERTSPITHDVNWIDTDTDEDEDYLPQNQHHQLPSPPRVLPSVAYRTPSPPPSGNKRNRVESTSWSPSGLPGPMKKHMSQHEFPTHYYSSSQHGCCTLRTVEKAINDAVDNGADMVDLGNMGLTDIPLEVRELQHITILSKDRIRNSSLKLFLYGNQLTKLNMELFALKNLSVLSLRNNKLESIPPEIVLLQNLCELSLGNNMLNHLPGEILRLRKLSIISVFPNPFQPIPTENTPNLPRQVMRSVPTPSLFEICCRAVMASPEKYDSHDMPFRITTQLETSKGIRRCQHCQCYVIEPDIEVLVWCSLLMSAHVPVLVGFCSSQCLSACNWDSIGLFAESIAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHA9</accession>
    <name>A0A8H7UHA9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_001989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHA9"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2179139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="37862" checksum="33663CD58B9772B7" modified="2022-01-19" version="1">MNLSLLIFPDSYEVLLPCSSSRNSSVPRLTGKLCIIASRPIECQSIELELRGDLTVDHQTSFDVLNTLIEGTPPPIVHIYHEVEIPAQKLQVGHTIIEYSIPLVKKMPPSYEGSYASVDYTLGAKMRYRKWMAISSLKSALCSLKFKYAPLQTTGAFSVRAHTCCIQDKLELEAVTPTAAIAGGEGMPIELNFRNGTRLGLSITAQIWQIEKSASYLSGPKRKNRLQYETRSQLNDVEETISMSLPSNLSTSFKVESTCSRVEVYHLIKLIMNCDEFTSAVCIDIPIKIIGITNRILHRDELSLHELLPAYEARDSTLPDYEWFPEESLTTTAEVPTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHB4</accession>
    <name>A0A8H7UHB4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHB4"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="648" mass="73056" checksum="2F0D8B8151D5388F" modified="2022-01-19" version="1">MSSIPSSISSFRSLPRFNSSGNNVLVESDNISGSSSSTSSEEMDEEESMFSDIKQVAHALDLFLDSHIAEAEQMTMPRANTTLYWGLASSCMTCLKAMMTFQPADIETSLTYLKQGVQLASGYRKKDVGFFESMTSWVKGGSSISVLSSMTTVQLHAELVWAESYLLKALVTVVHDESFVSFIREGIHVRNSYGVYRSLYKYVEYLKEEKAAGREARELDAHFLSGINFGLGCFNLMLSMLPHSLLKIVEFIGFSGDRRFGLGLLEAQGNWQSFHQDSEQPIPEQTEQLCGLRRQFCDMVLITYHTVLSTFVPIPDADQKFSDRLIQHNLGKYPSGVFFLYFSGRSLAARTLLDKAVLQFKQTIEIQKEWRQLQHICYWELGLLFLMKTEWESAHECFEILAQESNWSKATYTYFSACALYEEAQEMTNDAEKAKAMLKVEGLMNSIPKLTKKIAGKSIPIEKYVARKSRKFTAQNNRLLLPSLELLSLLVGLDVMPPKLQELHLARIAKALDNINLETATDTDDYCLANWLQACCARRSGNTELCKQSLEAVFKQQDNIALDHFIPYYAHYEAAREAIAHEEWAQAKEELNIIFTAHAGGYGIGKGAGAKSKYSMENVLQLKCHSCLHEINVKEEDALSSQVEDLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHF7</accession>
    <name>A0A8H7UHF7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_003780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHF7"/>
    <dbReference type="OrthoDB" id="2348006at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF42">
        <property type="entry name" value="PUTATIVE SUBFAMILY (AFU_ORTHOLOGUE AFUA_6G13760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="5">
        <location>
            <begin position="413"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2179993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1252" mass="138614" checksum="DA2B0D62247BA03E" modified="2022-01-19" version="1">MSTARALYDCEGLENSDELSFKKGDVINQVSNSEEDGWLVGVLQTSGQQGLFPANYVEVISDKEESHKPRNPAVAAKPPGIVGSKNNYTVRSSPSIISSSQSKSKVPEIASVSRTQEANDPDTTQISQEIDSPAMSVKALRAKLESSGTASTVPTKQPISLESPKPRAPPVASSPAKIDEEANEEPVESMKPSELRKKWAAVDAASKQNQPVGAALRTNTKRVSTVAEAPRRAENTMPMDTKPILDGKHLQSSSFVPTPVRSSPGNIPIIQPRPTAGLPPTPPRRPSTFSNTYSRSSVSSVTEEEDSNNASRPVSHSDRKFQVPPRTLPRRPEVQSQIYPSNKPSGPPLPSRPQSVSATPSQKSGPTPPPRPTASPRPTPSKRPSSVNLPRRPTSHMLPPATASIQKNIAVIDRTKYEKMFNQHSEQGYVYYEAAFDLWRASRIGDENIGQICHLVDIREDGWLDKKQFCAGMFLIDERLRGVCVPKSLPQAYFADTSNFSPQFQFVSPSPTSRYRHDNTIYVNPLIGTSGAGHVFPGATIPFGIAKPGPDMAGSDNQAGYNPDGMIKGFSQLHSDGWTYTVTHLELFGSILQNPSYGNIIVQPLTGTEWALYDYRSKRIENSESKSLHGYLANIVKYDFHDSDNATILINVGDDLMGSFMGGSISLDQDSNQNLRVVGNGMYRPSFAPYSTFKVYFCSAFNLAASNVSLFDGKVYNNTQTTLTGSYGGLGALVYFDKVTKERPLVTRIGISFVSTSQACESAENEVPTFDFDEVKELARELWKETLGKIQVESASLDDKLYRHFISPVNKTGENPKWNSSEPYYDDFYCLWDTYHGVMPLYALTHAKPLSEMVRGLIDIYRNEGYMPDCYMGLGPGFTQGGSNAEMPLVDFLLKHGKEYGDISWDDGFDAMIKDATVEPTYQGAIIHGRGDVDFYNENGYVPAPDGSTWDRPQQSARSASRTVEYARNDFAIALAAHALGNSSAYNTYIKKANNWINLWNPDIKEDGFSGFIMPKYKNGTWNNYPPQFCGPTLNHFSCFLDGRGGEFYEESSWIYSFSAPQDQFKLIELMGGPEIYTKRLDHYFEKGYHDMGDEPAFLVPYLYNWVGRMDKTTDIVRHLLRTNFWTNATGLPGNDDSGAEGSFVVWSMMGFYPVAGTDVYLLSSPLFSKMTLNMSVNSTFTIIANNLTETNRYVKSAKLNGVGFERNWIRHSEICNLKEDTTLELDMAAEWFGYGQNSLPPAISGDVPWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIM9</accession>
    <name>A0A8H7UIM9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIM9"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF148">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2183127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="350" mass="38180" checksum="84418E557C0F02BA" modified="2022-01-19" version="1">MADNRPDIHKPNEEPEGYRFTADQMLDQLPKDASISNKVYIVTGSHSGIGEETARSLSSHGAKVILATRNQKSAQAAMDRIKSKHPKANLQWLYLDLSDLDTVKTFVADFRKTGLPLNGLICNAGIMASPYSKTKQGFESQFGTNHMGHFLLIKLLLDDLIKSGPGSRVVVVSSAGHRFSGIKFDDLDFSDGKVYEPFEAYGQSKTANILCAKAFNEKYSDKGVEFFSLHPGLIRTNLDNSMSPDARNTSIARIASGPVQASFYKAAIAVESFLKPVFGNFIAPKFMKTVGQGAATQVWAATSPDLNGKGGAYLDDCHISTPKTEEAQDATGENARRLYDLSIKLVAQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIR9</accession>
    <name>A0A8H7UIR9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_000553</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIR9"/>
    <dbReference type="OrthoDB" id="3592703at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05353">
        <property type="entry name" value="hydroxyacyl-CoA-like_DH_SDR_c-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000013">
        <property type="entry name" value="Peroxisomal multifunctional enzyme type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000185">
        <property type="entry name" value="peroxisomal multifunctional enzyme type 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1050.10:FF:000001">
        <property type="entry name" value="Putative Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051687">
        <property type="entry name" value="Peroxisomal_Beta-Oxidation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024:SF2">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="12">
        <location>
            <begin position="10"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="777"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2184640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1057" mass="112749" checksum="FC14E7832D8FBDEA" modified="2022-01-19" version="1">MPADLRFDGRTVIVTGAGGGLGKAYALFFANRGANVVVNDLGASATGGGASSKAADVVVSEIQQAGGKAVANYNSVEDGDKIVETAMKAFGRVDIIINNAGILRDKSFTRMADADWDLIQAVHVRGSYKVTKAAWPIFKQQKFGRIIMTASAAGLYGNFGQANYSAAKLALASFGFSLAKEGAKDNIHCNTIAPMAASRMTETIMPPEILESLKPEFVTPLVGYLCHENTEENGGVFEVGAGFAAKLRWERSKGAVFKADDTFDPAAVGAKWEEIINFDNGAEYPTTITDTDFLGLLEQAKSLDANPKAEPLRFDGQVAIVTGAGGGLGRAYALLLAKLGASVVVNDLGGSATGQGKDSKAADVVVDEIRNAGGKAVANYDSVEDGDKVVETALKAFGRVDILVNNAGILRDKSFARMSDQDWELVHRVHLRGTYKVIKAAWPHFLKQKYGRIINTASAVGLYGNFGQTNYSAAKLGIVGLTKTLALEGKKNNIIANVIAPNAGTRMTATVMPPEMVEAFKPEYVAPLIGYLAHQNTEETGSIFEVGSGWIAKVRWQRTGGVGFPANKPLAPEQIAANWEKIVDFEDGRATNPGSTQEAFQSFMENFSNVSEEEAASKSEEKEESSGGLDVEAAKKLEFDTLDFSYGEKEAILYALGVGAKRTDLNFVYENDENFGVLPTFGVIPSFAAMNSVPFGDFLPSFNPMMLLHGEQFLSLKKPIPTSGEFKSKAKVIDILDKGKGASVVLGVTTTDESGEVLFENEFTLFIRGLGGFGGPKKGSDRGAATATNAPPNRKPDAVVQEKTSEDQAALYRLSGDFNPLHIDPSMSSMGGFDVPILHGLCSFGISGKHVLKAFGNNDPANFKNIKARFAKHVFPGETLETQMWKEGNKIIFQTRVVERDVIAISNAAVELTGATGAPESVPAAEASGSSSVGEPGFAASAIFEQAKKQMDSSSDAEKQEQIKKVKGLFQFDITNGDSKTQTWWIDLKQKGDVGKGKPPGKSDVTLVIKDADFMDLASGKLNGQKAYMQGKLKIKGQMMLATKLGAVLSQGGKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UK13</accession>
    <name>A0A8H7UK13_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_000506</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UK13"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000010">
        <property type="entry name" value="Cyclic AMP-dependent transcription factor ATF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00041">
        <property type="entry name" value="LEUZIPPRCREB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="142"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2184597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="245" mass="27708" checksum="55BF411462A94581" modified="2022-01-19" version="1">MSILAMQSFDAIPAADAALATPTRFLMDYYENPLTPSMGTFSMAETNPFEYSFQPAKQEISQQVIPASVSTQPQQLPPTPQSSANSSPRQSVHEDNSSDEHKSVSPKVRTRSRSTSSSSVKSQPQKRKFEAVDIEDDDEDAEEKRRKFLERNRQAASKCRQKKKAWMQDLEQRSEEITNRNKALHETVSMLKEEVLFLKNQLLSHRGCDCTVVKNYIQTSGTFSNFLNGNQPRSDGYRPNAYNCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UK98</accession>
    <name>A0A8H7UK98_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transketolase-like pyrimidine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_006930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UK98"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="5">
        <location>
            <begin position="581"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2182004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="939" mass="104932" checksum="1FD1F767264DDE40" modified="2022-01-19" version="1">MSTLTKLLSARRALNTRLPLVLSRSYHDDGVYGYRARKEYQLPDYDAEELANRMENGSLLRFVQSYRSHGHRGANLDPLDIMQREEVLALNPERYGLTDAKKTYNLAGILHVNQSKHDKSSKEEASFETILHHLQSTYCGRIAYEFMHIPSASERRWWYYAVESWNKPTLSSEKKKHIYELLSRSETFDHFMGKKFPNVKRYGLEGAESMMVALDRLFEISAKAGLKNVVVGMPHRGRLNLLTDLLQYPPQALFHKLKGNSELPVGAAGSGDVLSHIANSPTLDYEGKKVNVSLLHNPSHLEAVNPVVMGKARAKQMNLMDSEDQACALGDRVLGVQLHGDAAFTGQGVVMETLGLSNLPHYSSGGCIHIVVNNQIGYTTPAQNARSTVYCSDIAKMINAPVIHVNGDFPEDVARAMDLVFEYRDKFRKDIILDLITYRRWGHNELDEPAFTQPLMYHNIRSRQSVGKMYEQKLISEGVLSADGDNDKIGSNYYDTLEKRLSEAESYVPSDKQHLSGNWQSITHPMDYNKIPPVNTGVDESVLVDIGKQSVGLSDQLSVHPRVDKYHIQARLKRLNAGKGIDWATAEALAFGSLLAEGYNVRISGQDVGRGTFSQRHAMLVDQDTEKVVIPLNNLKTTLSDAKAPGHLEVANSSLSEFAVLGFEYGVSIESPNILPIWEAQFGDFFNSAQVMIDTYVSSGEAKWLRQSGLTMLLPHGYDGAGPEHSTSRVERFLQLSDDPFDHNDDTVVNPNWHVVNCTTPAQYFHALRRQMKRSFRKPLIVASPKGLLKSPLCTSTLSEMAEGTSFKPVLGDDSVADGSSVEKVVFVSGKLYYDLVKERENRGLSDKVALCRIEELCPFPRNEIASELSKYTNAKDYVWCQEEPQNGGAYSFMLPRLSKVLPSGQSLQYVGRAPLAAPAVGISQRHREEQASILKNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKB6</accession>
    <name>A0A8H7UKB6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_000825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKB6"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="378"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="597"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="606"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2184912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="639" mass="70357" checksum="A3EC16AAC7C1E461" modified="2022-01-19" version="1">MYKSGSPIQTTGHNLVGLWRPSFTRVENKLYIFGGGGQVTTDLHVLDLVDMRWSTVQTKGTPPKKRYGHTAVLWRHFIIIFGGCKETQDYCNDVHIFDIQKSTWVSPEIRGDLPAARYLHSAAVYDNKMFVYGGFAKNPDCTYVLDELSILDLETFTWSNRHAIPPRYNHSCTLIGHKMYIFGGKDEHGNTVSDLFTINLNTPSYTPHHVLGPHSLSGSSMVLLKSQHFCEALCGKLLVFGRYLTGETATNANGSACTAKSVYGLWLLDLDTLEWTKQECNAYFDVGGWNYFTIVEEPVGGYRSHSPSAMMMDSEDDATQITTKNLLFLGNTDPFRPQGYDHFRDALTINSECLGLYDIPPPQHSLEFAQLLNDPELSDFIIEPADGPPIHAHQVILMARWPHFRNIHKSGMIEATQRHLQIPEPHAVVLALMRYFYSDCLDEAEPWDIVADVLVLANMYILTRLKKICCERLYRRHLTVDTCGHIFERAIYAQEPGLKALVLEFMFANYGAVLKSNVLVSMNPQAREEFLEAVPNEAVLEVSKGRAAATVIAASISQHATSNHSQSTSPATSAESAAAQAAAAAAAAAAASVSNSSSTTTSTISGGYTSMPRSVTTGSLSMNSGGMDLGSMNGMSVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKK1</accession>
    <name>A0A8H7UKK1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">37S ribosomal protein S25, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_007216</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKK1"/>
    <dbReference type="OrthoDB" id="5542239at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016939">
        <property type="entry name" value="Ribosomal_mS23_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13741">
        <property type="entry name" value="MRP-S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2182289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="223" mass="25536" checksum="A556C08DE81D1105" modified="2022-01-19" version="1">MAYRAPPTELTKHVSRLLKGKLLKKPPTWFAAVQAVPPGPSVIRAQNTEVNIAGQTNAEKQFGQANRLPAHSINRHKQKNLKTRAPKPRPIVYPEDRLRRQFYKDHPFELQRPKLLVETTDGINRTNFSQLLLDGMHPAQVDGETVIKYQLHLMVSQNMTERQAYAKATSEFYEIRAQEEEEKRLAQSKIDSVFNALAAKKQTERTLQREEKAIAEALKSMTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7ULJ4</accession>
    <name>A0A8H7ULJ4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Periplasmic binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7ULJ4"/>
    <dbReference type="OrthoDB" id="409848at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38360:SF1">
        <property type="entry name" value="F12P19.7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38360">
        <property type="entry name" value="OS03G0120000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53807">
        <property type="entry name" value="Helical backbone' metal receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="54389" checksum="BAC13B29342325F4" modified="2022-01-19" version="1">MGSHIPSIEQEVPHKQPRQTMPVNFFGPSVYSKFYKALICAVVLAGPMLASAQQTSINNTACVQNYNAATDSNTDYFPNKVDADDATYFKISYHNNYKLLVNSYTNETFALYQCGTPIPTGLANGTKVFPVPVSNVAVMETIVVPYLEMLGVANSVTAVGSDALISSSCFQKFVQSDNIPTLSDTNSTASNLTLTKVDVEFGAYMADPTNNKSVSVSSSQDPGTLNRAEWLEFFAAFYNKEQLANTLTAQINDNYNRLKQAASGYNPKPLVAWTVYTAPSSYNNNTASWLISNATYKVQFAQDAGGSAMTSGTGGTATMSGTSYSNVSDFLSAINNVDVLIDETFVGDDFNSFLQNYNISAADQNNYKFIKNKAVYREDGVSTTAGGQDWLEAAIPMADAVLEDVINAINPSAPVSNYTRRWLRNIALNETIKYSTADNCTSNENDARADVAVNFTSTAKFSQPSYSSSSSSSTSSSTSQAVSFTAVSSTLLVTVLATFFAFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7ULV1</accession>
    <name>A0A8H7ULV1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_000447</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7ULV1"/>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="26"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="111"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="187"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="259"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2184538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="312" mass="35474" checksum="7D6B5A13BDC40E93" modified="2022-01-19" version="1">MESNDNLQDLVRSFLKEHTTYDVLPVSYRLIVLDTQLLVKKALAALMQNGIVSAPLWSSTDQKFAGMLTVSDFINLIQYYYSHSSVEDALHEIESFQIQHMRDVEKQVGAPAPQLLSIHPMSTLYDASKLLVESRSHRIPLLDREAETQTEMIVSVLTQYRILKFIAVNFQETRALRQPLSELKIGTYKNIAIATTDMPIIQVINMFVEKHISSVPIVDENNVVLNVYETVDVMSIARSGKYDELDIPVGEALEARPDDFPGVHTCTLNDTLYSIFSTIRKRRVYRLIVVDQDKKLQGIVSLSDILRYLIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UMY8</accession>
    <name>A0A8H7UMY8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UMY8"/>
    <dbReference type="OrthoDB" id="5556956at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027973">
        <property type="entry name" value="FSAF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053030">
        <property type="entry name" value="Ribosomal_biogenesis_FAF1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096:SF1">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15375">
        <property type="entry name" value="FSAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="253" mass="27972" checksum="03F1E429F8D7368D" modified="2022-01-19" version="1" fragment="single">SANTINDSSGPISEEKEMQTNDKGPEVVVFSDSAKKTVTGTSKAEYKAFMVRLLPHDHFCSFSKMEAPPPPPPKSVKELEEEEENQAHDRELKELLATSKLLEEYELEEMTGKERRRHNMNKLETLGVKKSKGLKMPIQMRLGMDQKQKEREQKKLQEAKDIGLYDKSLKHLYAAAVKPKDNKPRDKGITSGIGKMRGSTLTLSKNEIKRVEREGNKPKAVKGRKAGKGGSKGGSKGGSKGGKGGKGGKKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UNJ2</accession>
    <name>A0A8H7UNJ2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UNJ2"/>
    <dbReference type="OrthoDB" id="2354971at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="257"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2186308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="366" mass="41220" checksum="A3400A9383A83C21" modified="2022-01-19" version="1">MLYDDQDHDPSALLEDELMGMGQSLGSFGNSLAAELHIATVQPSPSASRKSMRHLSHGIELQQTDDFSANKLEEDLPIGVHQSLAHEMFSNQAGLVIAPGPMSTMSSTTLGHSRSGSLSTWSSVDVEENDPFEILKRQLEELNTAVWETKTLHKRLAKTLLSDQTLSLQNPLSTQITTDSFAPPLELVITSVVNLIDRMSRERERQFSVLRTIDTSVRTEGTWMSMEALSDIDVLLVAIKNTLHDVAYEFNNPVPLMQELNIETSAMADSLEELKEHMFVNKRQAQELNARLRAISKTVHDVRKDMREVNQLLAEKDDEDAVVLEKGEVKERVKEIMWGLDDLDERSSQELSRMKQFWDEFVSVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UP22</accession>
    <name>A0A8H7UP22_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UP22"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2185844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="119" mass="12816" checksum="0056ACBEBF09E2FE" modified="2022-01-19" version="1">MLRLIKLSSTKSTFIRRRHVVYLHGLNTGGQYRSWCLLRWALRIPKAAAFLTLGAGVEGGDGGNDIQEVKTGDMDESDDSVSNDMVFMPGGGVGNDDVAGNRMLVAACSVRVMTGVRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCF6</accession>
    <name>A0A8H7PCF6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_002934</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCF6"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="11"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="99"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2171312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="139" mass="15775" checksum="4AEA8F40C904C85F" modified="2022-01-19" version="1">MSTTHLTDDCLFCKIIRGQIPSHKVAETDKSYAFLDIGPLSEGHTLVIPKYHAEFMHEVPDEYLADAMPLAKKIAVASKLQYYNILQNNGKLAHQEVPHVHFHIIPKNSQEDGLTMGWKQRSVDQDQLKAKLAEIKQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCJ9</accession>
    <name>A0A8H7PCJ9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH:ubiquinone oxidoreductase-like 20kDa subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_009064</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCJ9"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12280:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit B 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005012">
        <property type="entry name" value="PRK06411.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56770">
        <property type="entry name" value="HydA/Nqo6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase-like 20kDa subunit" evidence="4">
        <location>
            <begin position="69"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2171403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="194" mass="21652" checksum="31A0D035A7A01B57" modified="2022-01-19" version="1" fragment="single">ASAPKSLARQTLSLQNRQMSTDVTKQNDVKDVAIGQPSNGAEFILSNVDKVVNWARQGSMWPMTFGLACCAVEMMHIAAARYDQDRLGIVFRASPRQSDVMIVAGTLTNKMAPALRKVYDQMPEPRWVISMGSCANGGGYYHYSYSVVRGCDRIVPVDIYVPGCPPTAEALLYGVLQLQKKMRRTKITQLWYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCQ5</accession>
    <name>A0A8H7PCQ5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">INT43_009128</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCQ5"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF215">
        <property type="entry name" value="ALPHA-AMYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034060593" description="alpha-amylase" evidence="18">
        <location>
            <begin position="20"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="19">
        <location>
            <begin position="48"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="14">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG2171467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="471" mass="51532" checksum="DA86BD78605E6918" modified="2022-01-19" version="1">MKTILSAVATATFMLATSANPVQYKIQKRSPTPLGTTADDWKTKTVYQLLTDRFSKTDGSTNSCGDISTYCGGTYQGITNKLDYIAGMGFDAIWISPIPENQANGYHGYWATDFNSLNSNFGSSDDLINLVNAAHQKGISVMLDVVANHAGIPQTSGDYSGYTFNSASQYHTECDIDFNNQTSVEQCWLSGLPDINTEDDNVINTLYGIVGNWTKTYGFDAIRIDTFRHIRKDFWPSYLASANVFSTAEVADGDSSYVGPYQNYSDSIINYPLYYPITRVFGSKNSMTQLSQQIATNKQYFKDITLLTTFVDNHDNPRFLYGTSDTSLFKNALTFVMLTDGIPVYYYGSEQGFNGGADPANRAPLWTSSFDTTTDLYTFTSTLVKDARKKISGTTVTEVDVQDNVYAFTRGNALVVVNNQGSSASGSVTVKVGSGIQDGTSLKDVFTNTTVSVSGGSITYNLHNGMPSVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD07</accession>
    <name>A0A8H7PD07_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_008329</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD07"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034922421" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="10"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2171603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="506" mass="55789" checksum="F5C4963BF4C70201" modified="2022-01-19" version="1">MKSANYLWLCVILVSIAGDGVNYENAFAGGLVQQNAFLWHMGWTETTIPYTLHQLIGPVANLGQLVGGISAGIFNDYFGRKKTLIMGCIITIIGNALLIASPNVPALMIGRILMGASAGFLNNGVAMYCSEVAQRTTRGTANNIQFLFGQAITIAASGVNLAISGLPISANWGWRLACSIIFVPMVTMGVAITFVCPESPRWLIMQHRYDEALEVLTRIRSDGEQTADVMLEYNEMKAAVLYEQENNETSWWNFVKNKGAIKRTLIAMSSSLWWIFNGGAIFSYYFTTVYAGAGITDTYTQYLLNLMNTLLAFVATCIGAYGIDKWGRRFAGITATGVAAISLFIMCAISVRYLDGNDSPSRAAGIAFIFMYNFETFVWQATWNTIGMLYGAEIWAPSLRARGFSLGCTTGMAAGFVSQYTALPTYDRLKGYTWLLYGCFCALACFQVWATWPETLGKNLEEIELYFDTGAAQQVRKVMEHDNMEREGAADDKIEVSVEKNATDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD76</accession>
    <name>A0A8H7PD76_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_008117</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD76"/>
    <dbReference type="OrthoDB" id="19141at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF43">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="5">
        <location>
            <begin position="37"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2171737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="205" mass="22242" checksum="A9B4106941BEBBEC" modified="2022-01-19" version="1" fragment="single">VFCRARGASQGGSVYGRSILKVPYTTTVTATNSGQDLIHRLDLRVGKIVQVDLHPQADHLYVEQVNLGEQAEESALHERTIVSGLVKYINSKDMLNKQVVVVANMKPSKFRGVLSQGMLLAASKGDKVELLEPAAGSIVGERVQIDTMQELGQPDEILKPKQRVMELVAADLCTDNSCIATWKNLALKTSAGLVRCKSIENGTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD90</accession>
    <name>A0A8H7PD90_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_008172</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD90"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051274">
        <property type="entry name" value="3-5_Exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044">
        <property type="entry name" value="3'-5' EXONUCLEASE ERI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044:SF61">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="4">
        <location>
            <begin position="84"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2171792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="288" mass="32967" checksum="1141123F94FAC81F" modified="2022-01-19" version="1">MSNAPESVAETGATDEVEQLVSGVAKMRLDLETLGLSSKGNKETLAKRLKKAQKIALTAADEANVKTSVTESDEQGPTVTPFDYYLFFDVEATCEEKDKRYPHEIIEFPVVLVEGKTFEIVDQYRSYVKPSINPILSEFCKKLTGITQESVDESPDFINMLNDFQTWMAKYSLFQEKSAIFVTDGPFDIRDFITQQCNHDNIPVPAYFFRWVDIKKAFARFYNGKPETIATMLDRLGMEFEGRAHSGLDDATNIYRIARHMYHKGYVFKKYSRHPMASVSVRKSRKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDK7</accession>
    <name>A0A8H7PDK7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDK7"/>
    <dbReference type="OrthoDB" id="3210850at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="334" mass="37992" checksum="8C23209296B66A76" modified="2022-01-19" version="1">MSSPMNVGMEWDEILSQFISLSCISVLSVLAGSKTSTERLRHLTYARLLILLIYAASWAFTTMSTILVATNNYNEISCALSILTCDVFYAGSKILIYAWLIERVWVVQAVKTKRMKTPLYRFHIVLLCPYFAIFSLMIVYREAFLNPDGTCTIGLQPPAAIPLMVSKAELAFVCYDFVFNLYMTWLFLRPLLQYSAVTEFVSETQIERNELRIVAKRTFVASCVCLLVSLANILILSILRHERGLICLTCCTFDVTVNAVTLHFVTSHTSPAREDTFIQTYRDTHVSDRDTDIFAIMDEHDTSTKASEHTVHTSDGETRLNETFGYEDMHDEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PE67</accession>
    <name>A0A8H7PE67_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ELYS-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PE67"/>
    <dbReference type="OrthoDB" id="2393733at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2172274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="741" mass="83626" checksum="8A55585B84CBBE70" modified="2022-01-19" version="1">MPRDSHVEVTLNVRNGCRRHNIGTVAGAVTRTNRQLFEQHVERYWKVSLQKWREPNKDIHELALLLSLNNRLHTMVRPVANSYALTALAAHEKPSDIIGGSLVCITENSTLQSHCPSIAFIYRYTSTRLEVRDYFDADSIYATLLSPTLPSDQKLKANSKNNLEYQRANWDKRGPLSSCAGNRERVPLYFIVKQSRSQSVASIEVCVPAVSTTKQAYIFVGGFNGEIEVMSYGEVQNEYGVIDSKIVTTLWKNMPVVKMSVYDLANNEEELVILAGQAERGCSDQGQTSRTPSMTILKVRVPSLKSMEVGKKEMTSKATDAALMLPPNSTTIIAMDLYVSGTDDIIYLSSIWAYQPPNRIGRVMYACWKVSSNIDKIDFLRQHVVKTTSRLLDACMSGTLSTVAILCCSGLDVAYTTNFQCIKGDARKHLYDYDATARTIRANENDEKHQTYDEKRSMLGSLLIIDKLLIAKGYGVQSQFRSSGQIISDALLYTVLDAMGETEFCNLSEDNHLSHDTRQRIQEYWSVDNLQIQGIQSVRQLKRATTYSDNYIWAIKQQFGVSAAVDFMKTHHIPVDGISDWEVASAFLECSPSFDAALCLSQPSFKTLNHSDIQKFLPRLVSRWFKAAYLEIEGNKRLSARLLGVAFDHTLERELVKYCSITNPSPANLSFLFSYYLNRYRYAEAMMIHDKLSQYEDESNVAMQQRKVIIDCTSKLVPSIQLKLALLDADNLTETQCGFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEA8</accession>
    <name>A0A8H7PEA8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_008146</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEA8"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17946">
        <property type="entry name" value="DEADc_DDX24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="316"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="558"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="169"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="747"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="241"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2171766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="846" mass="95729" checksum="FAEE8F0535D3670E" modified="2022-01-19" version="1" fragment="single">IMVWEVKDIGTKSAEPVKNKVKKNGKQKKPALSADEEAWNKLSMEAPPPMPEVDDFLLTGTKKRKRTKTQVETIHDLAWSEVEQSSSALLTDDAGGFVCLEELSDIDVEYEGDDATGKIIKFKKVAPTKKGKNQKKEKKHAPANPEKPLTIEETKQYYDLDTFNEKLAAQQLAEEPESKEADGDDMQLDEPIATNAVAMEESPDVEQENGTTSEAKLTVSEKKSQKKQEKLAKLKEKRKAAKEVAKEAAKEAKLDVEKEEHPVEQPDSQKKRLSVSDVDQDFDTSKWDEFNLNEAIVNALKYHKFSSPTPIQEKTLPLAIEGRDIIGAAETGSGKTLAFGIPIAQYLASLDKEESHHSLAALILTPTRELAMQVKNHIENITCFMDIRTIAIVGGMSAQKQKRQLGQKPNIVVATPGRLWELFSEEDEYLENLKHLKFLVMDEADRMIEGGHFQELDEILKAISLGNNNPDGTEATLQRQTLVFTATLSNALRFDRRKKKSKKSKSPSSDGTMGRRDAIIDRLELNKKDPAIVDITTTSAVASRLVEAKIDCLQKEKDLFLYYFVTRYPGRTIVFVNSIDAIRRLVPVSKLLGLEVIGLHAQMQQKQRLKNLDRFKANKTAVLVASDVAARGLDIPLVDHVIHYQLPRSGEIYVHRSGRTARANQDGVSLMLCSPEEVSLYKKLVLTLRDGEPYPDFPIDYSIQREMKKHVELATKIDKEEHRLQKINHDDDWMKRMANELDIEYDEDEHSVKKKKRKNAEDEEEETKIQNKVRAWKAELKHMCAQPLMPHGASQKYITGSTMQDLVERLLNTEKNERLPASFVTKAIDDVKEKAKINQRRKLAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEX7</accession>
    <name>A0A8H7PEX7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_000015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEX7"/>
    <dbReference type="OrthoDB" id="2504919at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF86">
        <property type="entry name" value="ADR321CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2172668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="37897" checksum="AA064169324148DE" modified="2022-01-19" version="1">MVSEKLYGLTVAISLTASVIQAFAITLQRRSHILNDAASPDDQRSSFRRPMWLTGFLMYTIANIIGSIFTIGYLPIVVLAPVGAMNLVFNAIFAKIMLGDPFTKRTAYGTLLIVIGAVLIGGFGVVHEPNHTLDDLIRLYKRPSFIVYFAIVELFIVAGLVSTHLAERKYNNPPVSLSDRTIMSYPQMKSLLGISYGVFGANISSQAMLFAKSGLELLILSIFQDQNQFIYPLTWLLVAALIVTALLQLYYLNKGISLCDTVILVPLNFCSFNVSCLFNGLMYYDQWERLFWWQIVCVLLGIAVLVSGVLVLSWRSMSGAIFLGDDDDNDDDDDDNKPSSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PF88</accession>
    <name>A0A8H7PF88_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PF88"/>
    <dbReference type="OrthoDB" id="5545891at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="236" mass="26705" checksum="F35B53F40EEA0497" modified="2022-01-19" version="1">MDRRRFLADCPRNLLRNYQPSPVHSVNMGSMSRKFDTQLSDIQYRLSGFTQPLVYFLHRTLQQDAITQKHIIDFVNAMHELLMDTASQTTQTRIDNLYRGTGMQGQAPRLDDSHPAPLLDLRTLLEHISLQKSLFTVGRRPRPQSQRIKPNLQGSSNAVDNLSSARGFGRAQTIAKGNRPTIRTSMRTFTVLPQSLGQVNRRVVCPIVIQDEYKIPFTSPSPIAVGPPSHPIYQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFA0</accession>
    <name>A0A8H7PFA0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_000198</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFA0"/>
    <dbReference type="OrthoDB" id="414863at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000017">
        <property type="entry name" value="40S ribosomal protein SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032281">
        <property type="entry name" value="Ribosomal_uS2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16122">
        <property type="entry name" value="40S_SA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS2 C-terminal" evidence="8">
        <location>
            <begin position="209"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="225"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="225"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2172848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="285" mass="31252" checksum="2DA1033A3390ED09" modified="2022-01-19" version="1" fragment="single">PVPNFNNMSKIPAILNPTENDLQLLLSAQCHLGAKNCTSVMTPYVYKRRNDGIHLINLGKTWEKLVLAARIIAAIENPHDIVVVSARPYGHRAALKFAKYIGAEAIVGRFTPGTFTNYITRSFREPRLIICTDPRTDSQAIVESSYVNIPVISLADTDSLLEYVDVAIPTNNKGKHALGLIYWLLTRQVLRLRGTLEYNTEWDVMVDMFFYRDPEEAEKEQAAAAAAAAEDETTWNAAPEADWAAEGIAAEGPAANAGAADWGNTPTADWADDSNTQAASSSWDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGM2</accession>
    <name>A0A8H7PGM2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_005027</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGM2"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034737">
        <property type="term" value="F:ergosterol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008204">
        <property type="term" value="P:ergosterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF9">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="526"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2173609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="558" mass="65162" checksum="010DB30511A8C47B" modified="2022-01-19" version="1">MSPDISNPSKMNGGHELLKHALHNNIHTHKSVSDDTAFDGVAVNALEERPPLTKINSSPATTTPVSNPAVHSKRRRRLTFRPRMTPLDLANPESTNDQFRGFFTLFWLAMGFYVIQTVIRCYEQEGILLSLVFFRLFSKDGVALMVSDLTMVSMTLFSVPFSKLMLKGWLPYDHIGFYLQHIFQGFFLFINIYWTFWRDWPWVQSGFFTLHTIVMMMKMHSYTALNGELSLKRRRLKYLKQYLPSWIAEHHNGEGSPKLSISPSLSDVPDDMSIASEISNKSESDYQGYSPEDAAELKAMESEIELIEEDLVHGKTVFPNNVTMKNYLDYLLVPSLVYWMEYPRTDRIRPWYVFEKSLATLGSFLLLYVTTERYILPKLYDPTMSEPRVIVELLFPFMINYLLIFYIIFECILNAFAEISRFADRNFYDDWWNSVTYDEFARKWNKPVHHFLLRHVYASSMEAYKLTKTNATFLTFFLSSCLHELVLVIVTRKVRMYLFILQMLQIPLIVIGRHPIIRKRSWLGNVFFWAGMFVGPPLLGILYCREVFWTSMKQAGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHI7</accession>
    <name>A0A8H7PHI7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_005220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHI7"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="236"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2173800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="424" mass="45789" checksum="515816F4B3DED1F6" modified="2022-01-19" version="1">MSLDRSTTVQSQRSITYDMSIIDESITAPPVEELLEKGVDPDDEYEGIRNRGWVYISEAFPGSNALQISFIGSMQSGLINLLGLFLPLVIQLAGYRGTMLIGTILAPLGLIAASFTTELWQLYLTQGLMFGIGGALGYQPAMMIPAQYLRRNRSLAAGICICGSGVGGLALNPVSPYKMKVSFISNYGFRASLRYHGIIGLGVMLIGNLLTKPKYSMPKTKLRNFKFFDTSLLTLPMSLLLLFSFLVPFGYLVPFYMIPMYAVSIGLTAEQGALILAIGSGVNAISRVVFGTMADKWLGRINVMFALTLLSGLSTMLIWPFAKSYACLLVYFLIYSASAGVFQSVLPAITTDLCGVDHIAHGMTMYFLAAGPGFLLGTPIAGLIFDSSNYLTVIEISASLTVLASLAALALRVVIGGWKPFTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHJ0</accession>
    <name>A0A8H7PHJ0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_005139</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0014 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHJ0"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005226">
        <property type="entry name" value="UPF0014_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30028:SF0">
        <property type="entry name" value="PROTEIN ALUMINUM SENSITIVE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30028">
        <property type="entry name" value="UPF0014 INNER MEMBRANE PROTEIN YBBM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03649">
        <property type="entry name" value="UPF0014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2173719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="337" mass="37056" checksum="33992FB4DB72C883" modified="2022-01-19" version="1">MDSLGIALQAAQVNDGEEKNTHLTWWNVGFASLFIIVNMVMSGSLGLGLEKPLVISAIRCVVQLTLMAFVLEDVFKAQHPAIIILMAFVLILLGCYEIIYNKSQKTFKGMFLVCFFSMSLSTMTVGIIGSRFAMAQDPFWTPEKFVPTVGMLLGNTMSGMAVAIGSCLSSLSDGQEKIETYLSFGATRWEAGLSVAVESVRLAMLPTINQMSVIGLIAIPGMMTGQIMGGASVLQAARYQQIIMFMISASTALSVLIAVVVTVTTVIDAEHRIRPERILRTKPSLWKDTKALPWTIWEMFHWLFLCCGRFQKAMTIDDSDSESGDSETHNERTPLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHM4</accession>
    <name>A0A8H7PHM4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_004215</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000003">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1570.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MPN" evidence="9">
        <location>
            <begin position="2155"/>
            <end position="2286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2174194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="2385" mass="278691" checksum="9E84D3B75D35E171" modified="2022-01-19" version="1">MTDFGSENQNRFPVPVGNSPSPYGDQQYSYSNGDQPESADMEFNWDDKLNEKARKWQQMQNKRYGEKRKFGFVEHEKADMPPEHVRKIIKDHGDMSSKKFRHDKRIYLGALKYVPHAVLKLLENMPMPWEQVREVPVLYHITGAITFVNEIPWVIEPVYIAQWGTMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYGDNILDVEPLEPIQMELDEEEDAAVYEWFYDHKPLMDTKFVNGPTYRRWNLNLPIMSNLHRLAHQLLSDLTDPNYFYLFDKKAFFTAKALNIAIPGGPKFEPLYRDIDTDEDWNEFNDISKIIIRQPVRSEYKIAFPFLYNSMPRSVHVSWYHHPTNVYIRADDPDLPAFYFDPVINPISSRNLQTEGEVKFEDELFGDEEEESEEIFSLPEDVRPFLEEQELYNDQTSNAVALYWAPKPFNQRSGRTRRAQDVPLIQSWYLEHCPPGQPVKVRVSYQKLLKCYVHNALKSRPEKAKNKRYLFRQLKATKFFQSTELDWVEAGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLCREILRLTKLIVDSHVQYRLGNVDAFQLADGLQYIFAHVGQLTGMYRYKYRLMRQVRMTKDIKHVLYYRFNTGPVGKGPGVGFWAPGWRVWLFFLRGIVPLLERWLGNLLARHFEGRHSKGIAKTVTKQRVESHYDLELRAAVMHDIIDMMPEGVKGNKSRTILQHLSEAWRTFKANIPWKVPGMPTPIENMILRYVKAKADWWTSVAHYNRERIRRGATVDKTVCKKNLGRLTRLWLKAEQERQHNYLKDGPYVSAEEAVAIYTATVHWLESRKFSPIPFPPLSYKHDTKLLILALERLREAYSVQGRLNQNQREELGLIEQAYDNPHEALSRIKRLLLTQRAFKEVGIEFMDLYSHLVPVYDVEPLEKITDAYLDQYLWYEADKRHLFPAWIKPSDSEPPPLLVYKWCQGINNLTDVWETSEGECNVMMETVLSKIYEKVDLTLLGRLLRLILDHNLADYMTAKNNVVLNYKDMNHVNAFGMIRGLQFASFIFQYYGLIMDLLILGLHRASEMAGPPQLPNDFLQYRDVQTETKHPIRLYSRYIDRIHIFFRFSADEARDLIQRFLTEHPDPNFENVVGYNNKKCWPRDCRMRLMKHDVNLGRATFWDIKNRLPRSLTTIEWEDSFVSVYSKDNPNLLFAMCGFEIRILPKIRNLNEEFSMRDGVWSLINEQSKERTAQAFLRVDNDSLEKFNNRIRQILMASGSTTFTKIANKYNTALIGLMTYYREAVVHTRELLDLLVKCENKIQTRIKIGLNSKMPSRFPPTVFYCPKELGGLGMLSMGHVLIPQSDLRWSKQTDTGITHFRSGMSHDEDQLIPNLFRYIQPWESEFIDSQRVWAEYALKRQEANAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVRTDFKQYQILKNNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFPSWEGLFWERASGFEESMKYKKLTNAQRSGLNQIPNRRFTLWWSPTINRSNVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAHLWQKIHESVVMDLCQVFDQELEALQIETVQKETIHPRKSYKMNSSCADILLFAAYKWPVSRPSLLSDTKDTMDGPTTTKYWVDVQLRWGDYDSHDIERYTRAKFLDYTTDSMSIYPSPTGVMVGIDLAYNLHSCYGNYIPGMKPLLQQAMAKIMKANPAMYVLRERIRKGLQLYSSEPTEPYLSSSNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQIIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKIEKFGDLILKANEPQMVLFNLYDDWLRTISSYTAFSRLILILRALHVNNEKTKIILRPDRSTITEPHHIWPTLSDEEWIKVEVALKDLILGDYGKKNNVNVASLTQSEIRDIILGMEISAPSLQRQQIAEIEKQTKEQSQLTAVTTKTHNVHGDEMIVTTTSNYETQTFSSKTEWRVRAISSTNLHLRTNHIYVNSDDIKENGKLVEKILTSEISLITLLTVTFSNSAYTYVLPKNILKRFITIADLRTQIAGYMYGISPPDAPNVKEIRCIVIPPQWGTHQTVHLPSTAPEHEYLSDLEPLGWIHTQPQELMNMSPQDVSSHARLLAQNKSWDGEKTITMTCSFTPGSCSLSAYKLTPSGFEWGRNNMDTSSNPQGYLPTHAEKVQILLSDRFLGFFMVPTDIWNYNFMGAQFNNNMNYALTLDVPKEFYHESHRAAHFMNFSTMEDSAIEADLEDVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHX6</accession>
    <name>A0A8H7PHX6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_005304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHX6"/>
    <dbReference type="OrthoDB" id="10422808at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2173884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="175" mass="16977" checksum="637CCB455AECF6E0" modified="2022-01-19" version="1">MPITASPGCALTSLVQPEGGNAQCIGNYIETVGACSFTALNQEFPAQCDSAFNCMLTYPGGTSHSLICNGSTQTYTSSVLEMSFSGSCTCTISGAASAPVAAASSSPPAAASTSIVAVSASSATGTPASSVPAAASSNAPASSSAAPAISNANKISKTSALLFSAILVSMLVSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIC1</accession>
    <name>A0A8H7PIC1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_004129</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIC1"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040031">
        <property type="term" value="P:snRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039772">
        <property type="entry name" value="Bin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010675">
        <property type="entry name" value="Bin3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024160">
        <property type="entry name" value="BIN3_SAM-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315:SF0">
        <property type="entry name" value="7SK SNRNA METHYLPHOSPHATE CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315">
        <property type="entry name" value="BICOID-INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06859">
        <property type="entry name" value="Bin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51515">
        <property type="entry name" value="BIN3_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bin3-type SAM" evidence="8">
        <location>
            <begin position="100"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2174109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="332" mass="38017" checksum="CC3A53B3602D18A6" modified="2022-01-19" version="1">MKAQTNESASSERGETSNPYLAYPGKSRNYDNKPPHQRIQLSTKRTSDAILGNRTGPKLMKGTRSKARNEAPSRGKLPVGLYGNYVHYYTSRRMHGEKEDPRMSLMDSSLFTDKRVLDIGCNSGNLTILLALNHKPTHIDGVDIDERLIKTAVNNLKSTYSLRDPGSDTVDTDIGLTSHYYPQSMTFMFGFLPLMPREKAPPGFPYNIHFKSEDWLNVETEKQKYDTILALSISKWIHLHHGDDGIKKFFHKVYESLNDGGIFVLESQGFETYARRRKDSEHIKTVYDSIQFMPEQFPAFLQNDVGFKSYEIAGESENEHKGFERPIYLFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJP6</accession>
    <name>A0A8H7PJP6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_006032</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the misato family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJP6"/>
    <dbReference type="OrthoDB" id="271881at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06060">
        <property type="entry name" value="misato"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049942">
        <property type="entry name" value="DML1/Misato"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029209">
        <property type="entry name" value="DML1/Misato_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019605">
        <property type="entry name" value="Misato_II_tubulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION REGULATOR MISATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391:SF0">
        <property type="entry name" value="PROTEIN MISATO HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10644">
        <property type="entry name" value="Misat_Tub_SegII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14881">
        <property type="entry name" value="Tubulin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Misato Segment II tubulin-like" evidence="5">
        <location>
            <begin position="2"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="DML1/Misato tubulin" evidence="6">
        <location>
            <begin position="131"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2174970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="510" mass="58452" checksum="06A6934F2C268C65" modified="2022-01-19" version="1">MHEVLTIQLGQAANFVGTHFWNAQNEYFEYGDTAQEPEFDHDILYRSGFTQRGIETYTPRVMIYDLKGGFGSLKKYNKLFQDNSDDHQDTWGQKVETFKSPEYPRNQYQKQLEMMDEGIETTPDTDLNLDDSVHVWSDFNGNYFHPKSLNQINQYQTGNSLQPFDTYTAGYNAYDENEKETDSFDENFRFFVEECDQLQGFQIMTSIDDGFGGFTRGFLENVRDEYPKTSILTYGISNSNVPASMKNSQKILLNTSMAAAGLSEYSSLYVPIHLPTAADIKQPWARHLNINPSLQYHTSAILASAVETASVAWRLKKRSTHLTDMISSINWRGDTSIASLSLCFPLEVGNDKEYKNVEQIMPKGNDEFKLLKNLTVGKAKVCISYITCNRETCIDNIFDCLRTTNMPSNMRITANTGVPLPVSFPKLLSPNYVKQIISNEDSSKFYAPALTQLCTGTQFFSYFEQYQQRLKGVNYRLFSDYEEGDRGQSIEDFVELKDWLIEKADNFRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKA2</accession>
    <name>A0A8H7PKA2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_001239</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKA2"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000004">
        <property type="entry name" value="26S proteasome regulatory subunit rpn-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="15"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="289"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2175592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="325" mass="36677" checksum="212EF9264E876F1B" modified="2022-01-19" version="1">MPATTSTSISPTTTVTVHPLVLLSVTDHYNRVAKNTKKRVVGVLLGQSKGKSVNVANSFAVPFEEDEKDPSVWYLDHNYVEAMNDMFKKVNAKEKMIGWYHSGPKLRASDLEINELFKRYTPNPVLVIVDVKPKDISIPTDAYFAIEEIKDDGTATQKTFMHVPSEIEAEEAEEIGVEHLLRDIKDNAVGTLSTRVTDQLNSVRGLQTRLEDIRDYLQKVVAGQLPVNHQIIYNLQDIFNLLPNLQTQEMVKSFSVKTNDQLLVIYLSSLIRAVIALHNLINNKIENLKGEGITNGEEQKESETKDGEEKTDEKKDDEKAKEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKJ3</accession>
    <name>A0A8H7PKJ3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_001057</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKJ3"/>
    <dbReference type="OrthoDB" id="5204190at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="124"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="214"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="338"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="289"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="521"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="613"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="544"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="573"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="635"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2175410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="652" mass="68737" checksum="C1E51301C1FC923F" modified="2022-01-19" version="1">MSDSGDYSSVPPPPSLDSGNPNLNFNDALSKARAIAEKLKQNKDSASPTMGSGQKRGYEDSYDRGYSRRDSRDDDYQYERENKRGAYDRPQSSYDSYGSRDKPRYGLGSDERKHSSYGPSASQHVRKEEFGVPNSIVGLVIGKGGENLKRIEAASGARIQFGQDEGDSERRCNITGEDDQVQVAKDMVMQVVNDASTTDSNRRGGGMPSAYGAGGNTVSVSVPGNKVGLVIGRGGETIRSLESQSGAKIAIAQENPGERSYERTINITGADDAVDRAKALIDEIVNGGYGGDRGGYSQRGGYDDNQRGYGSGANAYGPPRGDRGGYGGPGGHRGGQPGDENDSINVPQSSVGLIIGKGGETIRGLEQESGARIKVDQASSAAEERTILLYGQPDAIALAKQLIQEKIAGNLRFGLLVRIIDLRGTSSSFFDSILQVDWRDGGGRYGGRGGYNNRGYDRGGYGGQSGGYDSSSAGAGAGANAGYDYSQYYGYYNQGSGEAGSDGKGGSNYAGYYQYPYGSYSQYPPATNEDGSKAEGGAPQSTEDGQQSGSAEGQSSDQQAAAAAYYAQYYGQQGQGQGQGQDQGQGQGQGQGQGQGQDSQYYQYYQQYYSQYPGYDANAPATDAAAGTNSAEAPANTSAPSEPQASPETKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKK3</accession>
    <name>A0A8H7PKK3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Heat shock protein 60</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_001278</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKK3"/>
    <dbReference type="OrthoDB" id="1733909at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2175631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="599" mass="63466" checksum="9A5103A88A0C7212" modified="2022-01-19" version="1" fragment="single">ALPLPGSVSYLFLHSNHLTMHRLATKAAKPVARFSSKSSTGVLNRLYSTHKEIKFGVDGRAGLLKGVDILAKAVAVTLGPKGRNVLIEQPYGSPKITKDGVTVAKSIVLEDKFENLGARLVQDVANKTNEAAGDGTTTATVLARAIFTEGVKNVAAGCNPMDLRRGAQLAVEEVVKFLKKHSRVITTSEEIAQVATISANGDIHVGSVIAQAMEKVGKEGVITVKAGKTLEDELEITEGMRFDRGYISPYFITDTKTQKVEFEKPLIVLSEKKISLLQDILPALEAAATQRRPLLIVSEDLDGEALAACILNKLRGQLQVAAVKAPGFGDNRKSILGDLAILTGGTVFSDELDVKLEKANPELFGTTGSVTITKEDTIFLNGAGSKDLLTQRCEQIRGAMNDASTSDYEKEKLQERLAKLSGGVAVIKVGGSSEVEVGEKKDRFDDALCATRAAVEEGIVPGGGTALLKASKALDALKAANFDQQLGINIIRQAIQRPCRTIVDNAGGEGSVVAGKLLEEHAENFNYGYDASKNEYVDMIKEGILDPTKVVRTALVDASGVASLLTTTECMIVDAPQDKAPPMGGMGGMGGMGGMGGMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKP4</accession>
    <name>A0A8H7PKP4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cyclin-dependent kinase 8</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">INT43_001295</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKP4"/>
    <dbReference type="OrthoDB" id="6284126at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07842">
        <property type="entry name" value="STKc_CDK8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000408">
        <property type="entry name" value="Serine/threonine-protein kinase SSN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="21"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG2175648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="384" mass="44038" checksum="656BA6950C2CC108" modified="2022-01-19" version="1">MPMTEYKRKRDACRIKVLDKYEIIGFISSGTYGRVYKARSRDSNDPREFAIKKFKPDREGDSHHYVGISQSACREIALCRELRQENIVGLEEVLLEDKAIYMVFEYAEHDFLQIIHHHLHTERKPIPEVVVKSFLWQLLNGVAYLHANWVLHRDLKPANVLLTKEGVVKTGDLGLARLFNRPLQPLFNGDKVVVTIWYRAPELLLGSRHYTKAVDMWAVGCIFGELLALKPIFKGEEAKMDSKKNVPFQKSQLTKIFETLGTPTKERWPAIEQLPDYSHLSSFVQYPNQLKSVYQLMPGAKSEAGFNLLSALLEYDIEKRISADDALNHPYFQEDPKPVMNVLTQQGIEYPLRRVTSDDIDIKSAKPGQPSKDDSGRPAKKARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PL09</accession>
    <name>A0A8H7PL09_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_001322</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Degrades free oligosaccharides in the vacuole.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PL09"/>
    <dbReference type="OrthoDB" id="10261055at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000004">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000002">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000001">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054723">
        <property type="entry name" value="Ams1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22907">
        <property type="entry name" value="Ams1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="9">
        <location>
            <begin position="529"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2175675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1102" mass="124977" checksum="E4E6D4FBF6441769" modified="2022-01-19" version="1">MGPMQRNSSGAKPLETPRLIRSITIDRCSNFTSGGANGNDINLLSQLYKARTSSEEFISLLVFSVPDLKRISFEEAIQQEFRPTRLGEWFGPSWATHWFHVQVRIPNEFAGEEVHFIWNADNEALVWSMDGVPLQGLTGGAGSDARHEYILTTSARGGDPIQFYIEMACNGMFGTGNGLIGPPDPNRFFNLNELDLAVPNKLAWELLYDFQIILGMSRDLPQDSLRAAQALHTANRIVNVFRAGDDRTLEEGIRIAKEFLGAKNGDSQHEITALGHCHIDTAWLWPFDETIRKAGRSWSTQIDLMDRYPDYTFICSQAQQFEWVKDNYPKLWERIREKVSVGQFNPIGGTWVEMDCNIPSGESLCRQFLLGQRFFEEQFGKRCTVFWLPDTFGYSPQIPQLILQADMKYFFTQKLSWNNINKFPFTTFYWTALDGSRVITHMAPSETYNAQCTPEELIRTQEYTNSSLLVYGNGDGGGGPLAGMIERLKRMENVDGLAKVKMGGATEFYEGIEKSGAELSSWKGELYFELHRGTYTSHAITKRYNRSCEFLLRELEIFATLSMIADPETFIYPKSEVERFWKMVCLAQFHDVLPGSAIEMVYDDVMRMHTEVDTLGTVMRDELLDTVLELNTNIPEGKRGLVVFNSLCWPRTEIIEIPLAEGLPNMKQYSAFGRTGYALVQDIPAFGSRGFLLQDTPSYTPVTFETDRNNNIVIDNEFIKATFDKSGHLIGLRDKAGYGRELIREGERGNVFTMYEDIPLFWDAWDTEIYHLEKGRQVEKGSVQILEQGPLRVSLLIEKPISETSRLRQIVVITAISKRIDFETELDWNENRQFLKVEFAWNINTDQATYETQYGTIQRPTHFNTSWESAKFEVTGHKFADLSEYGYGVALLNDCKYGYAAHDNIVRLSLIRSPKAPDANCDIGHHVFKYAVYPHEGHFLQSDVVAEGFKFNVPLQSRVVSVAKATALSEPISHFRIEGAPNVVLDTIKRAEDSDDIILRLYEAYGGHATARLITAMPMKTIHRCNILEDEIGGPIYVNEVPTEAVATNGRRGVSSFSTNLRVLDDDVVEMQQKAQSEAQAEGALIQIKPFEIVTLKVNIHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLI8</accession>
    <name>A0A8H7PLI8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_005471</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLI8"/>
    <dbReference type="OrthoDB" id="1689029at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000034">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF0">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="14">
        <location>
            <begin position="7"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="13">
        <location>
            <begin position="282"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2176237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="440" mass="49165" checksum="4CE6865209BB9FD4" modified="2022-01-19" version="1">MTTDKYQYLEGFNNHHTSEALPDSLPKGQNTPQKCPYNLYAEQLSGTAFTVPRSHNQRSWLYRIRPSAVHEPFERLENGNELLTCSFANANITPNQLRWDPFDLPKDGEQVDFVTGLRTVAGAGDAATRNGLAIHVYHANKNMDKRAFYNADGDFLIVPQHGPLDITTEFGKIMVQPNEICVIQRGVRYSVDLPDGPVRGYILEVFGAHFELPDLGPIGANGLANPRDFLTPKACFHEEDNGDWQIINKFLGKLFVAKQDHTPFDVVAWHGNYAPYKYDLAKFCVINSTSFDHIDPSIFTVLTCKSDTVGVAIADFVIFPPRWAVQEHTFRPPYFHRNCMSEFMGLILGDYEGKTGGFQPGGASLHNVMTPHGPDAAVYEKASSGELGPVRVADGTQAFMFETCLTLSVTDWGLKCCQKVQPDYWKSWKALKNEFTGSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLR2</accession>
    <name>A0A8H7PLR2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber evidence="3 8">2.1.1.233</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_001193</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233" evidence="3 8"/>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLR2"/>
    <dbReference type="OrthoDB" id="203237at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF21">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016305">
        <property type="entry name" value="LCM_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="160"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR016305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2175546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="288" mass="33001" checksum="ADF6524E60FDE4E8" modified="2022-01-19" version="1">MNSSRLEREEYWENEDDVVRGTNDDATISRMSAASLGYIEDPFVHFFVKRPVQRPPIINRGSYLRVMALTDIVQQFLQCSDISHKKQIVSLGAGFDTRYFLLKAGIIPVDSKTQFKYFEIDFPEMTAKKAFTIKRQNKLASMLINPVELSSSDYALIGGDLREWSKIAERLTHHGFQADLPTLFISECVLIYLAPEESQSILDWITANVQNAMFLLYEQILPDDTFGQVMLRNLKSRNIELKGIHAYPTLEAQIQRFKQLNWGGALAVDINTLHDRPSAQNEIKRYAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLV5</accession>
    <name>A0A8H7PLV5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongin-C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_005682</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLV5"/>
    <dbReference type="OrthoDB" id="249087at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18321">
        <property type="entry name" value="BTB_POZ_EloC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000035">
        <property type="entry name" value="Elongin C transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2176442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="102" mass="11625" checksum="60BECBC06011F600" modified="2022-01-19" version="1">MAEQESEYVKLISSDGFEFIIHREAAMRSGTIKNMLSGAANFTESLENQVTFRDIKAIVLETACRYLYYKWQNEGSTTEIPEFVIEPELALETLMAADFLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PML5</accession>
    <name>A0A8H7PML5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gti1/Pac2 family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PML5"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="54696" checksum="03246597839546C7" modified="2022-01-19" version="1">MSVVESFHGYVANTTDSLLLYEACRRGLLPRVSRRLQEKERNCLVRSGSVFVFDEKESGIKRWTDGLVWSPSRILGNFLIYRELDRRASQGGKRIIEAKEQEKEETSNEYDDAEKMRERALVGSLTNSYKFKKGGLIKKSMSIVVDGVHQNLISYYDLEDVMAGRLRTPSNVPELAILEISPDFLHKQNFRIPLLIEPGGEIGEQQQDLPSPPPSSSSSTSSERRQSTREPILPPPGSQSNIETEQAFMAPQHRNSLPFYPPQNMAAGHDYSDLTGQKRKYSLVEGAMERQARQAERQMSWSPSVYRARTPSIDHMSHSLPTSYGIPMMPQYGRQAPSHMSDSLAEPLPSDSNATTTSATQLAPIQHSFRPPFGHPIDPLPTPTSLSTTSVSSLIAPISAPNNLPYAYMHVPDRRIDESPFMPPIGGRSSGGGGSMAPHHNPPNELFSSQSFHAVNHNTIQNRNDAYVATNSFMNEPALVAGNWSEYDLQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNY5</accession>
    <name>A0A8H7PNY5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_007940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNY5"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25880">
        <property type="entry name" value="WHD_CHMP7_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="5">
        <location>
            <begin position="165"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="884"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2177283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="930" mass="103243" checksum="F1C8CD8292AC4614" modified="2022-01-19" version="1">MSYPGNYGSHGSYGQYPPPPQQQYPPPGQPYPPPPPQNHRGPYPPPPQQQYGPPPYPPQGGNSPYPPPGGSPYPPPGNNGPYPPSNGQIRPPAYTGPDPVFGPNDPSMSSANYPQPPHSSHNQAPSPVPYGPPGGQPNSQFYMHVHPQLQNRPPPQFQLSNCQGRKRALLVGINYFNSPNQLRGCINDVQNMKKFLMTLYNFRSEDMVILTDDQQDPKFIPTRQNIISGMQWLVHDARPNDSFFFHYSGHGGRVRDLNGDEDDGYDETIYPVDHKRYPGESGQIIDDVMHDIMVRPLPPGCRLTAIFDSCHSGTALDLPYVYSTQGNLKEQNLFKDAGSGLLTAGLAYATGNLGGVLSSVMGVGKKVMTGRNVAQKNRAENSSPADVIMLSGCKDDQTSADATEAGQNTGAMSYAFTTALRQNRQQSYQQLLNTVRTILKEKYSQRPQLSSSHPIDVNLISYRMTDKSNDSLQTYLQNQYPEFDPKKASSRLSSLYSDFSSLKETNSYGYEANIAFWRSVILKAVQDGMIFCSGYKLAVSEEGLVNALDYGKHGRPLGLHNVLKEMIDAGDLVPVESVIDAGKMSSSPWSSYLLSIFVARPLKYAATLVGAHRPSGLLAVMPALKQLASKITEEHQTNQNISITDNLMTVDTFRKRYSNSLIPQRQLTDADIWLILRYLESSKAVAISELNRGHGVQIMLKFANAATIAQKKTVEITDTDKGILSIMETSDSLKTQIENLESTMSQLTIATKECLSKKQKPQALYKLKQKKRIETVLEKRLQYLDAMDTIIFKIENSQNDAQMVQAYDMGANALKNVLSSADLDIDNIDLTMDKVQDAFADQKEIDDALQLSMNEVHEAQFEGVSNEDLELELAELEQLEAKEQLPAKQQQQLHHHHHIPVPSHKPIIHQEKPVEEPASSQKTKIPLELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPF5</accession>
    <name>A0A8H7PPF5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="6">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_002985</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPF5"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000005">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="9">
        <location>
            <begin position="34"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6 7">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="47"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="126"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2177738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="330" mass="34319" checksum="E6D84F5A09F22691" modified="2022-01-19" version="1">MFAAKHSTILRATASVARRSFATTGYDSTYKNLMINKNTKVICQGFTGKQGTFHSEQAIAYGTNMVGGVSPKKAGQTHLGLPVFASVREAAQETKADASVIYVPPPGAAAAILEAIEAEIPLVVAITEGIPQHDMVKVKQALLTQSKTRLIGPNCPGIIAPEQCKIGIMPGHIHKRGKVGIVSRSGTLTYEAVNQTTEVGLGQTLCVGIGGDPLNGTNFIDCLSVFLEDDATEGIVMIGEIGGSAEEEAAEFLKQYNLTRANPKPVVSFIAGLTAPPGRRMGHAGAIISGGKGGAQDKMAALEAANVIVSKSPAKLGVLLKEAMTEAGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPR8</accession>
    <name>A0A8H7PPR8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_003422</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPR8"/>
    <dbReference type="OrthoDB" id="2391341at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="120"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="122"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="174"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="290"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2178169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="323" mass="36176" checksum="2DD36B1BEFA88447" modified="2022-01-19" version="1">MSSAAMDEPKPPKPPDRRESLAISAILNEESVEPRSPPADTEMDFDPRWKRRTWPSFNTAFPPISDPQYRQDDPMQIVPVPSGLPPFLTTSQQSKSNSNQILVPEEATIRHLPDGIVVCGITKGKRKRISPDQLRALVQVFKETDTPSSEVREKLAEQLDMSKREVQVWFQNRRAKASRMKGPNRENSTDRINKHRRKSSSNSSLGIPNTFVPPPFPANPALVDHHRPRRYSAVPVLQTVARPYTNIQSLKPLTQLPPANQPPMPYSGLHHNSENPGGWLHPIAPKPFSSLPFNGHPPGQTSIPPGHSYLPSGMRKLQISEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQA2</accession>
    <name>A0A8H7PQA2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor Opi1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQA2"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013927">
        <property type="entry name" value="TF_Opi1_Ccg-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08618">
        <property type="entry name" value="Opi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2178203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="56539" checksum="D8B4320B20C7D64F" modified="2022-01-19" version="1">MTSRESMDFVGLTFTATRTLSSSTQYPKVVPPFFSINPEIMSSASQLSIGSLCEPDHSKAHSRERESDRTKPPHLSRTRSNSDTSSLPSLSNSSTTHNTPLTTPTATEFAHDRFATSVPSSSSWMSSAYKAYGQSRVMRYVESGVRSLAVPIYGRIEKSLREEKPVDKIYMQLRDEKPSSSTEDEDMTSTTKAMANTSLDSNANGKRRNRRHSRQLSNDHKNDRLSTPRVATRSTSPHRRAPYSTTSSTRSRSPIVRQSQPRSRWQQLVVGAGSAAGTTAAVISEDSMKCLKYCLNWLQYAVSHIDQQMSILRNFLVSLATSSNPSSSQAVAAPSPSVLSAVKKEIIDTLRKVVQIVSKYAGSSLPAHARSAVRGFIINLPGKWASVSDVRSTTVSPVASPQMHPHGMSTSQSQDLNAHESAVRLLQFGGESVEMLNSVSGVFSDTVDRAELWLDRLRVGKSSSSAGNEDIVLPALKVHDQSQGISLPSLHSVTDNQLHQRSGYINMPTNDVDMDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQN3</accession>
    <name>A0A8H7PQN3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="2">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003376</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase Pus10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQN3"/>
    <dbReference type="OrthoDB" id="271937at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2510:FF:000001">
        <property type="entry name" value="tRNA pseudouridine synthase Pus10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048741">
        <property type="entry name" value="Pus10-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048742">
        <property type="entry name" value="Pus10_N_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21238">
        <property type="entry name" value="Pus10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21237">
        <property type="entry name" value="Pus10_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pus10 N-terminal eukaryotes" evidence="5">
        <location>
            <begin position="137"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Pus10-like C-terminal" evidence="6">
        <location>
            <begin position="328"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2178123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="584" mass="65573" checksum="EBFCF0C5E08ED71D" modified="2022-01-19" version="1">MAVHVDKKMRLDDNLNQGIQRANDLYMQKTSFLGRRQKDEADQISPVLPNMRSVSGDINHAKCALLLQVLFKNVRVPRFGIVSIDGSSKLIQSTVMHMYALNHESVPLTLYLQLKEILGVIEDANTTYKFEKLDTICPACVGVLQHADGCQVIDPIINKLETENYMATTYNLSLTLPTSMLPRNHALALHVYNKLVEQGQSAAVASMVRADLLDSKDPIKTVLAYHIKERYNIQQVVDSPLKMTVVLDHPETVGDHVFLASVSSPLMKLVKQRKKGQTFFTGDSRVTIVEALKSLPDEEAMQVTKVPPEPATTTFDIKVELLHDSTLIGGRYIKLSREYSQTPWSIRGARLTDFSVSESIGEPLKKYFKCDDYKFSTAGREDANVRMLGHGRPFYIQMVNPRIPEVSPEMYVKMEEEINHSENSHAVLVRHLGRIQPADVKIIKEGEQTKRKTYSALVWLSTPITDELIEKLNQVGSKEFIVSQRTPIRVSQRRAHMVRPKTIHHLSVSKLPAKSIGTDENMKAKSQFLRLIMDTEAGTYIKEFVHGDLGRTSPSFASLAGAAADILDLDVLEVDLVWPPHTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRA2</accession>
    <name>A0A8H7PRA2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRA2"/>
    <dbReference type="OrthoDB" id="74247at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PROTEIN NATD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435:SF9">
        <property type="entry name" value="PROTEIN NATD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="135"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="252" mass="28043" checksum="20BA85DA0E5697D1" modified="2022-01-19" version="1">MTHEQAPIDLSHDTTHSQPTLKEATNGSETTDSTADFARKSTRTRSTRRQTGALKDEAAKSSGGTSEDRPAASEQALKRTRKNAGNNHKTNQLTNKHAKDANTASKAEEQSKINTRIIPTVRLNASKTITGADVIHDDKNMLFKIILDDKGTAAALCYLPTRFRGIIEFYHTEIPLEYRSRGIGDLIAHYAFQWAENNNYQVLPTCSFLQRHLKHQFPDEQGLWSCVIHNEQEGLNRIAKSSTSQPAPSSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRD0</accession>
    <name>A0A8H7PRD0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRD0"/>
    <dbReference type="OrthoDB" id="20127at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="207" mass="24010" checksum="82A81E484D23A8CD" modified="2022-01-19" version="1">MENEHFHYTNSAVRLGVMFALFLMYFSQPDIWPRQQIRMTITDGYIAFIKLYADHAFAFCALSTQTYSNISDMATYNQLESLYGFLKEIRQLHWNRNVSNYLDESKLDHLENLTKMYSDAKKELFKTRHATLAAQKLMKDLANIHETNATHLQRVLESSSLGSSEDFASAERELVQRYETARFNSILKQNRKAVNDTSSSVLKEGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRM5</accession>
    <name>A0A8H7PRM5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRM5"/>
    <dbReference type="OrthoDB" id="2272068at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="422"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="805" mass="89685" checksum="CEAD482166751E31" modified="2022-01-19" version="1" fragment="single">MSRPETACPACHMDESLKPVPATPSTVAFAICTSCEIRVELVSVPASPKPQPATSATATISQQDFLALVARVDGHDQVLAELAALRKELASVNKQNATLRAELAALKATPAQQQQQTRQTLPRQQQVPRQPPTVAPATQTPITAPITATWAQRAASGTKKKPNARQIAASARAFIPATGPQGFDFVYLPKTRKYQRSEIRSRLRDVGIDTSRVLDIIYPARDVIGLLVHVQYRALLKETLLQKKIETIDSFDPLDPKHIADPRHAPLGTEDRRRLAVDLHRQRLLHGLEKMRPHVSPAVARSYVEIGWIADTDVPQRNTPRHKDAGAAFRKEDTSHKEDALLHKETIDVMSEDSEDDECSLPTSWDQHHNYALPVIDPRDARRRNRGQYGITTLISPTCPFPVLPLPSSSPFISSFRIGTTHIVCCYIPPTLGGPDDSAAYNDILNSIPLLPDTIICGDFNARLGDITGDSITTTRGRILTTWMEDRQLLLWQTPAIFGVPTFCTSRGGEVHQSVIDLFLSNFPADITEMTVRTDLSLSSDHRLVMAALSLPDMVDDTSRPPGRRMWNLSRLQEDEVSALYVRAFSSASQALRVRLLAHLDQPQLGRPDIDGLAEELNELIYSALSRSVGDKKPRPKHWKWFWTPALMDAAAARDYCYRRWNRAVGLDKIPWWERYLTALHAFRLGVKRARRQAYRAFCDALERNFAAATSKIKAIRRRRQTQPTYCHPDGPMVAVETMSQQLASVSDGRFLPADRPIAPELPPGPHGLDESPFTIDSVGAAIRRLPNRKAPGADHLRAEMLKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSK5</accession>
    <name>A0A8H7PSK5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_001963</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSK5"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2179113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="385" mass="42531" checksum="FFF07BC7D5C28959" modified="2022-01-19" version="1" fragment="single">MKTFQRPLSTLVAPLKHSTAVRPFRIQPLVNLTLKKHFAQQVQTIEEKKDDEKVLLNSYHSWLDRLPPKLAPYVFLTRMDKPIGTWLLYWPCAWSITMAAYSESLPASQTAYMLGLFGAGAIIMRGAGCTINDLWDRDIDDKVLTTFHQFVFADSSLLNCFILQVERTKVRPIASGAITPKQGIAFLGLQLSAGLAILTQLNTYSILLGASSLSLVVTYPLMKRITYWPQVVLGLAFNWGALLGWSAMTGSCDLSVVAPLYAGGVAWTLVYDTIYAHQDKKDDIKIGVKSTALRFGENTNKWLGAFSGTFVSMTALAGYINGQGLPFYTLSVLGTAAHLAWQLKTVDYNDPADCWKKFKSNTWVGGLIWSGIATDALWNSIQNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSL7</accession>
    <name>A0A8H7PSL7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Trehalose synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_001874</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSL7"/>
    <dbReference type="OrthoDB" id="937291at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052078">
        <property type="entry name" value="Trehalose_Metab_GTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049438">
        <property type="entry name" value="TreT_GT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779:SF1">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21269">
        <property type="entry name" value="TreT_GT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trehalose synthase N-terminal" evidence="8">
        <location>
            <begin position="252"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="7">
        <location>
            <begin position="504"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2179025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="738" mass="83981" checksum="40D6B6B28BBB2C57" modified="2022-01-19" version="1">MPPNPEVPLHTNRRFSITALPQGIYLGLDISHDIPSHTFHYAISVHDGSYSTDYYTDKIVVDLTMGHAHGVKDAENKLIAVLANFAQANHYKVQSVGVSLQVNDEDSRDLLFHPPSITSKLWFELDAIPFIMETRGRDLDERASAAVRKSVIWLSPQYPGNIPRISVGFRHVVEGQSYYISDLLRTLGSSLFRITIARGDVIIEKNHQIDLNDQIHMVDLENYQSTVCDETWRVVTEIAEEVKGRNLRLSFFNSTPQGGGVALMRHALIRYLRLLGIDVSWYVARPKPEIFDITKRKFHNVLQGVADPKVRLNDAEKQAFIDWSDENVQRFWGDQSGPLQNSDVIIIDDPQVAGIIPHIKRLAPKSTRIIFRSHIEIRADLIRDDPTGPQAETWNFLWKFIKHADLFISHPVNNFIPDEVPRRNVVLLPACTDPLDGLNKEIKSYNLTYYRSVFNRVCMDQGANEVDWRRPYIVQVARFDPSKGVYYNRVMKKENIILTDFVGIPDVLESYRLLRAKMDSDERFMDEDIPQLVICGHGSIDDPDGTLIYEMTHKTMATEAYEQIASDIIVARIPPSDQLLNIILRGAYVALQLSHREGFEVKVTEALAKGVPVIAYIAGGIPLQILDNTTGYLVPISDVQGVADKLFGLFEDPDQRETMSKNAVKYLTEEYFTVWNAIAWLFMCNEISRNKEESEGLIGEDATRNRNGGLGDGKWLRDFWQAKYQYKGKKHAKDVDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSR0</accession>
    <name>A0A8H7PSR0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent RNA helicase DRS1</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP-dependent RNA helicase drs1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">INT43_002065</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-binding RNA helicase involved in ribosome assembly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSR0"/>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17947">
        <property type="entry name" value="DEADc_DDX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000842">
        <property type="entry name" value="ATP-dependent RNA helicase DRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="242"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="446"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="103"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="590"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="15">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAG2179215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="669" mass="74784" checksum="30E18C617C8D781C" modified="2022-01-19" version="1">MSDFDDFIGTIDDNVQIVEELSEEEAPVVKNKNKKAKKAVKKNTNGDMDNSFSFSIEGGGAMKGGNMDWDFTTTREILKAQTLVPRTNIDDIIAKKLKEERNLKKGKKRKAVEETEEADVDKENAGDLISDNDEDVAADGFGGGVIEDDDDESEGESDSDKSSSESEDEEDNVQQHDMDSDEDEEEKNEFEIERKKAYFAPETDQPAMTYESFAAMNLSRPIQKGLAQVGFVAPTAIQCKTIPVALLGKDICGGAVTGSGKTAAFVVPILERLLYRPRQNASTRVLILCPTRELAVQVHSVAVKLASFTDIQFCLCVGGLSVKSQEMELKQKPDVVVATPGRLIDHVRNSPSFNLESCEILVMDEADRMLEDGFADELGEIVKSCPKSRQTMLFSATMTDNVDQLIRMSLQRPVRLMIDPSNQAASKLIQEFVRIRAHKEGDRPAVLLALCKKTFKRKCIVFFRSKAAAHQMKIVFGLCGLSSAELHGNLSQEQRLEALEKFRDGEVDYLLATDLASRGLDIKGIEVVINFNMPQQFSQYLHRVGRTARAGRNGRSVTLIGEADRKLLKMAVKSSTKTQVKHRVVPAELIVKYKTKLEAITEQVKDVMKQEKEDKAIRQAEMELKKSENMLNHANEIYSRPARTWFQNDKDKKKSKDVGKTAYKAMFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PT05</accession>
    <name>A0A8H7PT05_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_003555</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PT05"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.10">
        <property type="entry name" value="Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032353">
        <property type="entry name" value="AZUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042556">
        <property type="entry name" value="AZUL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16558">
        <property type="entry name" value="AZUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="880"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="279"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="1210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2179772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1242" mass="140457" checksum="BEF6F88FDAFA879E" modified="2022-01-19" version="1">MPAVDDASSQQQQTSISTSPLLSPSEERDSLVCLGSTNKDPRQPPQPTQNPRINGTSNANAADINLHHSNRKRRSSNGSNKIPSLPANPLRQHSTDALAQNFRDNGRAVANGSQPYPLKTYWSKERLPANYEEDKKASCNKTLDSQIAHKKLDYTKQRHATIKRATANYSFKVKQYFYQLLSGCDNRKCDNRFCASSSHKALSLNPDAALVLSIHLASKGQTKFCPGTHELPDSTIIRFFETHMRPSSNETSSPDTKSFLSQLFTSASSFQPVLYSNEDPKVADDADTSKVAPNNSHTEEDHTNIPYSMDKSPGTTLYDDPFPDRNIQKLPSQVREFWGNVSAGVLSAINGNRRPLNEFEYHDERGSWWKPSRRTNKYEKFCGPRQNKTHVRTDECGHVQYDDEPTPSSPNTDLIAAAVAHKAIGLRQFKTEFEKMSATDCDDTFKLLIDNVKQSFQHWDGLGNSFLDMNEESSSDQRTCTTIVNRAALSEFYHLLAASNKKNAHVLLKTASQSLEMLLTRLILNCEHACQYQATAKTIELADEPDEYFDTHKAIKWCRSIVYAMQWYLDQKQSNITMADDAQRQLNELKTSTNDCAGETADCSTTSTIVQPPVTVGEDILMQKLVTILSKISGYKSSALRAMLLDSLQSFDEESMSAFIKVCHTFLDDHYHSSPFKLGEDDHVIRSAKALELLYDANQQHPNNPIVPVSTFYNDSLNRILDVKDEYRIWKRVQLVGEGRHSASSIVKLVGAGKTNTFMNLNESQRRTRLFLTTTSTSVLLPFPLMHEYQFSIFSYPFLLPPPLKRKILHIDAMAHMSSEYEDACVNHTLVAHAQRLLSDSPKMVRNLETSLRSATCPYLLLEIHRDHFVEDTWQQITRRWADLKKPLKVRFVGGGEEGMDQGGVQKEFFGVLMEHLIHSPAGLFEVDPDTRSGWISANTGVFNETEKSLDIDEETRRSFEMFGVLMGLAIYNGIILGLQFPKVFWKVLTCASTSQLESGQANDRACFTIEDLEEGWPSLGKGLRQLLEWENDDVEDIFCRSYEISYRMMDKVVSIPLIPDGENTPVTNENRKQFVDDYCRHFMYTWVREPILAIRRGVWSIIGGSAVAMCTADELEVVACGQRDGLDGLDLDMKELEEVAEYDDGYEHNHTVIRHFWSIVHELSPQHKRQLLLFVTASDRVPVGGLKELMFVIQRNGPDSDRLPTALTCFSRLLLPEYSSREKLKDRLLVSIENAKGFGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUC2</accession>
    <name>A0A8H7PUC2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_004040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUC2"/>
    <dbReference type="OrthoDB" id="27198at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.200:FF:000003">
        <property type="entry name" value="DCN1-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF12">
        <property type="entry name" value="DEFECTIVE IN CULLIN NEDDYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="3">
        <location>
            <begin position="54"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2180251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="251" mass="28990" checksum="1B36A5B4DB3A5987" modified="2022-01-19" version="1">MGAKQSTQAPPKRKKSSQQLQHAPSIQINVATPNVSPQSPTSLTKRPSSQGTFYSEKQCMDWFEQYQDPDMQGTITPEGMTKFMNDIGVSLESVTVLVISWQLNASSMGYFTREEWMSGMENLNICSMPQLKEKIPEFERGLQDPVQFKELYRYTFGYVKNKDQKCMDVDVAIVMWKLMLGNQSPHVDPFIAFLNDTQPVKVINRDQWQSFLEFATTVSEDFHDYDEMSAWPVLFDEYVKWKRGQLDSMQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUL3</accession>
    <name>A0A8H7PUL3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_003979</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUL3"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14127">
        <property type="entry name" value="STKc_CK1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000160">
        <property type="entry name" value="Casein kinase I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="38"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="392"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2180190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="463" mass="52808" checksum="6CFBD2CF69FD3114" modified="2022-01-19" version="1" fragment="single">RSIPIASASSQPMTPHSPSAAEAANSSSSSSNVVGVHYRVGKKIGEGSFGVIYEGTNLLNNQQVAIKFENRKSDAPQLREEYRAYKILNGCTGIPNAYYFGQEGMHNILVIDMLGPSLEDLFDMCNRKFSPKTVAMVAKQMLTRVETLHEHNLIYRDIKPDNFLIGKPGTDAADMVCMIDFGMVKQYRDPKTKQHIPYRERKSLSGTARYMSINTHLGREQSRRDDLEALGHVFLYFLRGQLPWQGLKAATNKQKYEKIGEKKQSTPVKDLCHGFPEEFGIYLQYVRKLGFEELPDYNFLRELFNKVIRSTGQEDDLVYDWKLLNDGKGWEVSFYVHFVSFWNQTGGGVFPSPRTSIYRQHVSRNTQLLHQSSSQQPLNSALNVPPNTAQQLLQHSNSRSNRQSRNSAANKEIRHSNLIQEQNAYRSSQVMDSQNRSKHQQPEQQKQQRRGFWSTVTCGLCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVX6</accession>
    <name>A0A8H7PVX6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trehalase</fullName>
            <ecNumber evidence="4">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_003970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 4">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVX6"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF1">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034104497" description="Trehalase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2180181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="596" mass="69311" checksum="0FF01514B11834FD" modified="2022-01-19" version="1">MRHPLFFAIVYALVLIATARTYKSCDSPIYCEGPLLRTVQLSNIFTDSKTFVDRPTAKPVDEVLKAFQQLGITPSVTDIRMFVEENFLEPGMELSQVLIKSNKQPQILERVTDPAYSVWMSDLNQYWSNLTYTFNTTFLCDGCQTSILPTKRPFVVPGGRFREFYYWDSYFVIEGLLYSELNDVAKGMIENFLDFVETYGFLPNGARIYYLNRSQPPFLTRMIKRYLDFVDDEELFTRALPILDTEYEFWMKNTTVEIYDPENDEKHYLNRFNVEYPYPRPEAYYEDWHTAHVDKDMTDQERVDLYSDLATGAETGWDYSSRWLRNKNFNGSSQFELLKSLNTRAIVPVELNSLLYDMEVQLSQWNTGKKKAYYQRRAEQRLHSMDRLLWNDEYSSFYDFNLTSQCQQIEFTPANYFPFWLGAIPERIAKDNKKLLSVFSELEGILKLYPGILTTTLVETGLQWDLPNGWPPLQYVTLHALLNVHKRITENKYTQSLSAQVDSLKTVARDLATRYVESGFCGWWATGGNVPGYLSNRGHTTDTGHMFEKFNVTVIGRSGGGGEYRPQIGFGWTNSIAFWIFANFDDFRAPNCTLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWG7</accession>
    <name>A0A8H7PWG7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PQ-loop repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_008572</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWG7"/>
    <dbReference type="OrthoDB" id="292213at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000005">
        <property type="entry name" value="PQ-loop repeat-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052241">
        <property type="entry name" value="SLC66/Scramblase_ANY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856:SF9">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2180990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="29517" checksum="02A52A667B501416" modified="2022-01-19" version="1">MCCVAFIEVSQGGMEQVDILRIFFWLGKRFDLTLLIQSIFMIIAQIILLELVVKHRPIPSASARYSVVGRASFSSDLSSVDDPDFEDVLFPPSSQRHFIGRLWNRFWAWERFIDYIIFLLGFTGVTLVLYIIFGSFPVFIEILGAVSLSIEATVPVPQCIANFKARSTHGFSWLILGTWFLGDGFKFFYFIFTGSPLQFIICGAFQLFVDCIVVVQFIIFAPAMRKRLGIRPPQHEIDAEGELEFRRSSEQRPYEPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXR2</accession>
    <name>A0A8H7PXR2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_008982</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXR2"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034834978" description="FAD-binding PCMH-type domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="118"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2181399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="572" mass="63009" checksum="D2360884B637DCBC" modified="2022-01-19" version="1">MRLLLACVAWFALLHSILGAPHSRCRCLPGDPCWPSADEWNQLNASIGNNLLISFPLAQPCHDPHYNEQECAFVHQNWQNGVWRTNQPYGLFQTTFEVLNNETWSCQLNATRSSECTLGNLPVYIVNASSTDDIQKAVIFAADHNLRLSIKNTGHDYLGRNSAAGSLSIWTHRLNQIELFDNFVTNDPSANGSTAVTVQSGVQMAQLYKAVATKNWVVVGGAANTVGVGGYVGGGGHSAISPNYGLAVDNALEFTLVLPSGEVIVTNGVQYTDIFWALRGGGASTWGVVIDVTFRTYPGPSVLSYAEFGAYTTNTTLYKMMLEKFVDAQPAISEGGFGGYWYNSNNTLWFLYANLNANKTEASKVLEPFINYTASIGVENQLNMSEYNNWNQWYLDFACPGGDCGSVSGGSAYLSSRLIPRENFERPGELADALINAYNAISGTGGTIGHLVAGGEVSKKDPDSVAVNPAWRKALWHIVISVGYEDNAPPAERERQHRLTTKTNDFFRDITPGSGCYMNEADIYEPDWQQAFFGSHYDRLVEIKRDIDPDHLFICRNCVGSEEWDESLNCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXW8</accession>
    <name>A0A8H7PXW8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc/iron permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_008738</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXW8"/>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF16">
        <property type="entry name" value="ZINC TRANSPORTER ZIP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="122"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2181156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="37913" checksum="21F0B93A5991543F" modified="2022-01-19" version="1">MSTQAAVFAFLFPGSAMVNSLLATCYISIFPNLLLYFVPPDIDTSSLNTLVSFAVGGLLGDVFLHLLPHAFLGEHNEGSGPAHVDYDEHKNVLVGMGIFGGLFFFFIMDKLMRVFAGGSGHDHSHSHSHKKDDDIHAHSNDVDIPDPSQLRVRNRGQKEEQPVDEKHDTKKSSADAAGIKLSAYLNLFADTTHNFTDGLAMAASFYASPSVGATTAVAVFFHEIPHEVGDYAILIQSGFSKRQAMMAQFTTAIGAFLGTIAGIAIEEFAQKGAHLAEKVAPGLLGTSLQWGDLVIPFTAGGFMYIATVGVIPELLEVSQNVKKDFRQALSEFAAMLVGLAMMTFIAWNEASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PY24</accession>
    <name>A0A8H7PY24_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PY24"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053020">
        <property type="entry name" value="Smr_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417:SF1">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="180"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2181246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="280" mass="31587" checksum="666DCA65B8372A82" modified="2022-01-19" version="1">MGNKQSLESAFDKANDVYHEIKRKQQQQQGGQQGGQQSQNQYPGSYSHPQGQQGQYSQPSHEAPYQQQPQHLHPDNHQGYQNNHQGHQNNTHGNRVSSPHLDEGDDPEYTRLRDLAHQEALARNDCYSRSQAAYNGGDGAGAKSLSNEGHEHDRRMKDYNQQAADFVFNVKNKGRNGDEIDLHGLFVQEATERAEEAIARCQREGRDHLTIIVGRGNHSVDHIAKLKPAITHLVEKYNVHVEPNTPNPGCLYVEFGKGKGDMRWLDRLEDKVRGGDCVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYK7</accession>
    <name>A0A8H7PYK7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_007217</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYK7"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="6">
        <location>
            <begin position="224"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2182290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="392" mass="44789" checksum="A946DB94F135C124" modified="2022-01-19" version="1">MTNYAKTTLLANGLALKRERPIAYTNKESPLDQVDVRWFAAPIYSQPAIPPPLTIPDLDQGSPSKANRRKRGKSLGRGPSLRLKTLFVSPLPHRLMLQDTSIHPYQLQKEPRNNCLQQLRSPPLRSPVEGKQKDDLSNEDRFWLRNTTTHIYQHHNQVNENWLIRKLSLTKLQLSSVSVNRLQRQFSFKKAIETLTKQESIREVYWKHKMPAPKLIDRQADTDPVLTETLAEALRPHLPMRMRLASSWTLLYSLDQHGISLSTLYRKVKGKGPCVLAIKDANDEIFGGYLNEPLKPSSSYYGTGECFLWRATQADSDNCSVRAYPWTGKNEYMVLSETDFIAIGGGDGKFGLWLHSDLERGHTDECPTFDNEPLASSRKFDCVELEIWGFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYP7</accession>
    <name>A0A8H7PYP7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYP7"/>
    <dbReference type="OrthoDB" id="341353at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF72">
        <property type="entry name" value="TLC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="218"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2182335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="33250" checksum="313D52E5A6A8C2A8" modified="2022-01-19" version="1">MSTVITKLTVTKALSQPSVLIGFPLSIALYVSFFFGAQKSKIATSEKQVSWLLTFMSSAGLTLASIPRFYNFWRSGWDIRSFQVDNTFDTMILCYFVTYLILDLTLGSIYYKGQINLLTGWIHHSVYTFMTVYFLCHRLGGFFVVASILELPTLIMALGCLWSNLRSDYLFASTFFSFRLVFHAFMIKTLKQHHHIQTLWIVAASIFPLHLFWFYGFIRQQKRKYQVYMERKRAMKQKILEEKENLQSVASCSTSSVSNFASKKEISRLRKFFAQGKRLSFGSLSGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYZ8</accession>
    <name>A0A8H7PYZ8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYZ8"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2182470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="342" mass="38750" checksum="0FB87DE07BCDFEC5" modified="2022-01-19" version="1">MKVFNTLADHEYLWKHITSVWAGFKNHVLTPDFVMKPLAAMDSNFNATACQALQGPKLQPIWISETAVYSFDALTYLYFILAFLLVPYPVYRMVANIFKWEVNQKTLARHWSDLMLGLSYGCIVFVFGNYSKAFSWITVVAFYPSIFAYALIAELPFTKTSLPRIKTWPIGMWIVFLLALGFILAFAAFHIYLAVELPMPFVIYYVCALAIPIFFILTAVALVYESTHNVFNSQVFRIKSAFSSKKARDSDEEQSDNENNRPKSPQPLTGGANAGESSTPNLVNFKVLTPVSLHLHHWQIFYVLCFFTRFDHPASQVAAGIVLACYMQGICAYGYDPLVNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZ31</accession>
    <name>A0A8H7PZ31_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZ31"/>
    <dbReference type="OrthoDB" id="2372305at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2183359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="158" mass="17403" checksum="E65F4339AE14A661" modified="2022-01-19" version="1">MTDAVQIANEIADRFDASPKIRVTQQQAEDAINEASTGLQESELSFSQICKENERINAILDNIRQQSSGLQDTFDQIDDLEKFINHVANTFNQVSDSVSSMERSVMTSSGLSMGPIPMSFKFLSGPPTNVDAQTYFPPPGEVDIADTSKFFSSEKNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q078</accession>
    <name>A0A8H7Q078_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_006695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q078"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF6">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="118"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2183687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="410" mass="45641" checksum="29A15971E1149EC9" modified="2022-01-19" version="1">MPFNKILIVGSGPAGLTLAQYLKRHDVPFQVVEKAPVSRLQGYSVSIHFALPYLVLALGEDKMKGFQEYVSVNHTTDTGVALVNYDGQVLLKLDGIPALSGKGIRANRTRIRDRLMEGINVETDVEVTDVHFGDHQAVVKTSKGDICADIVVGADGLRSAVRSSIIGNKVQELSVVNLSASRNITRQEHEVFSKYSPTHFIMFGPKTSNRQGVVNFFYSINDVSNDGETYNVRWVLSWDQGLDLREIPNTNDGLHKIAYEMADQFYEPVKKLIQMTDPSTKIWFSHASQCMPDYSLDNRGQITLIGDALHAMTAYRGEGLNHAVMDAVLLGEQIVLAHQGKRSVTEALTTYQKQAMARGRTAVKASYESAMGAHLGFSTLYKFSMRVLNLVVSNLQDYNIMEYFWGNTHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0T9</accession>
    <name>A0A8H7Q0T9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zf-UBP-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_006466</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0T9"/>
    <dbReference type="OrthoDB" id="273556at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16457">
        <property type="entry name" value="RING-H2_BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12437">
        <property type="entry name" value="RRM_BRAP2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011422">
        <property type="entry name" value="BRAP2/ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047243">
        <property type="entry name" value="RING-H2_BRAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07576">
        <property type="entry name" value="BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="349"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="8">
        <location>
            <begin position="386"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="675"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="537"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="636"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="695"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2183460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="704" mass="79544" checksum="F9C5D74B85282242" modified="2022-01-19" version="1">MQLYRLKIQLFRSNPATSLPNDLFKALPTNLGPDHIAQKQSKSQPNRRSSHTRSRSQKQSTNLGHHPEIPPTPLPSQKEESTRPTKDNSKNSKVLQSYHKPQPDFRLGKITIEWIDNQEQDMSQYKRGYASAVRGEEAASTSTSSAPAPEVQSPPMGTITTVKGLSDLNYGIIHLYKEHGGALVSKASEISVNTLESTSAKADVSHTTEIDSYDGTMVCVLAVPTYMSATDFLKFTASVNQCVSHYRIIRDAAPNKYMVVMKFRDSSSTQEFYRKFNGKPFSSMELKLRVQPEICHVVYIKSVEIDTTMIAPYTFPHLYETLKEDRKVLKANEEESDSHTDLADELPTCPVCLERMDSNITGLLTILCQHTFHCYCLSKWGDGSCPVCRYSQKPIGAEKNSARHTVTGGGHNHHLQSEDANECFVCGAIESLWICLICGHIGCGRYHDAHAYHHYMETNHLYALELETQRVWDYAGDGYVHRLIQNTIDGKLVELPGANGDDSQSIPQEKLDAVSLEYTYLLTSQLESQRMYYEDHLESLTAQLSALSSQVKTLAGEVQLVRAENDSLISHTRQTEKKMKDVEKEKEKTERKLETVREKCDNIRKEWQEEKEVSIGFFNALKCRIVAESVHELQMATSLIKKNEHLKEDNKAKEQTIADLSDQVRDLMFFLESRERIQDNPEMEGGSVEVGPASKGKKARRGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q150</accession>
    <name>A0A8H7Q150_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoside transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_006411</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q150"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF88">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016379">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2183405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="52544" checksum="26F3BD388C1FAE98" modified="2022-01-19" version="1">MNRIKTFISDVLRPGESPASFEALLTSDDRDEFDRDEVAGIPPEDPYNLVYWIFVLQGAAMLLPWNVFITASTFFANRFAQTPYAETFQNYFSTYFTASSLLTFAYALWSQKKANANTRVVCALFINTIAFCAIMVTVPISSFVQYSYFYFTMLLVSLTGATTSFYQIGIFAAASRFPHKYLQGIMSGQALAGTAVALSSILSALAASPTSEPDEEAIRKSAMLYFMSALLITLVSLGSYIALLRQRFFIFYMKDVSTSVRASSAENNDEDSDPEMLFPVEAREITILGVLKKIKWLAFSVAYVFIVTIAVFPSITSLVKSVQAHPSTSIVVTQLPRMLQDDIFVSFHFLIFNVCDWIGRLLPLVDWLRFTRPSLLTGLSLARTAVIPLFLICNVVAADKTLPVVIDSDVAYFLLLMFFSTSNGWVGSLCMMAIPDLSVLTTPEEKSLAGSIMSFSLAFGLAVGGVMSFVVRSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q179</accession>
    <name>A0A8H7Q179_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q179"/>
    <dbReference type="OrthoDB" id="2384193at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2183450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="498" mass="56145" checksum="CA88396241ED314C" modified="2022-01-19" version="1">MIIDNPFTPILIPERAVELAFLYVWFLIRMWQIDRFACLRPSRIRQGELKNVTSTKIKYEEGFAPNPYTGQIITKPVQMWTPADQQLVIPTNYSLCVGFSLQTGSLFLLQCFWNYLANSVAKASFMSSREFKLYIAWIFIAMALFPVLQWNFSRSVYPTTWQEAIPELVYGAALFIIALLGVVSHFRFRKLIYQTRDSTNGKAITSKIAYFQDLNALLTVSLLIDGACFIILSADGLTIFELSQVSNPNQFIYITLVAIEKLILTCALFENRFTADLFICIANFASVIIWFIVILIFHPKPGTGVGLNSTQQNSGYVFSNPAASMANNSRAINTQSMGIAVTSNAGREDYIPYSPSLAKATPVSPTPTSTLPPRYGSPPPLQPKSAQRPMSPPSPSYRSASPHKNIHDIYSSEPMATEAGVDFYPVVSRKYSDAYKQPRNNRNIGQEEIALQQWDDDTVRSDYDGRSQSPNYHRQTDENWLRQSPLKQNPYNRSSDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q212</accession>
    <name>A0A8H7Q212_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">von Willebrand factor A domain-containing protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_000590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Exhibits ATPase activity in vitro.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000587">
        <property type="entry name" value="von Willebrand factor A domain containing 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000663">
        <property type="entry name" value="von Willebrand factor A domain containing 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039891">
        <property type="entry name" value="VWA8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21610">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21610:SF9">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="ATPase dynein-related AAA" evidence="9">
        <location>
            <begin position="97"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase dynein-related AAA" evidence="9">
        <location>
            <begin position="454"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase dynein-related AAA" evidence="9">
        <location>
            <begin position="793"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1509"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1524"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1582"/>
            <end position="1599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2184677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="2297" mass="255735" checksum="170BDAB7074D0B46" modified="2022-01-19" version="1">MPKDLESQKKKSAKRRLKQLGKTINPSVAGWSDSEEELAIGQEETIKSVRIGDVVVNVEPPTAPELVPEYDDVLFDDSQEVLRHLRWMMQKDKLKQDIFLIGPPGPLRRGLIMKYAQMTKREIEYVALSKDVTDADLKQRRELSKGTSYYVDQAAVRAAIHGRILVLDGIEKAERNVLPILNNLLENREMSLEDGRFLTNKDISAMEASNPNYLKFEKVHDRFLVFALGLPIPRYIGYPLDPPLRSRFQSRDIKVPGFDAQVKQFMQAAGSKVDRSIVERLVSIGMVLGVQSGNNKADAEIDVPEFPSTMDTLAPIYAKFPHSEIRFLLDLVYPFPLLPTCNTEELSVIESVYRRFRVFAPAVEANQDAVDQQVFSGYNLANIERSPRDQATVDGSYIRPQAVATLSHDSGNHTAVVVECGSHAFGPAEYFVETPYHKRILTSMVMAHAGGHDFCLIGTNKGVGKSALIRHFARNLGYIIEYIPLFRDMSSRDLLQRRSTTSTGDTVWENSMLVEAALNGRLAVLDGVETLSFGTLTTLQRLVTEREVQLPDGKRLVNPKRFASLMKKHNWTQEQLLTEKKMIPIHPSFRIVCLARAGTGGGVDGAAGAWLTPEVLTMFHFVVVGALPNAEEQLVLKTLSPGVDENKLSILLKFANRLRRDTDENVKLLSNALSTRQLIRICRRIAYFPEDCLHTAVHKVSLSRFMPAVARMALDELLKADGIDMPDQTLVQDLTIEVIPSRENPKKVKIGSVTEQVFENGDPMLIPHVVFHENPAQTLVLQEMLKDYQLGEHLLLIGNQGVGKNKLADYFLQLLKLPREYIQLHRDSTVQSLTATPAIRDGVLIYEDSPLVKAVTQGNILVVDEADKAPTFVTAVLKSLIEDGQMVLGDGRRIVSNKTDAENGDDIVIHHNFRMIVLANRPGYPFLGNDFYREIGDVFSCHAVDNPDMASEMYLLRKYGPDVPEDLLLKLSTAFNDLRKLVDEGLISYPYSTRELVNIVRHMQIYPEEGVSKTLQNVFDFDQYDPQSKELLIEIFQKHGIPVGLQSEFSIELGQSVELGDPIVTQSWSRNPQLTQGAQKCAFEEADIAVRGGWDLENGKKWRELERKEGRSLTFTEQLYHFDIPTRGEALDIATLDDGTLFVVTTNPVTLHRIEPRHQKIDSLDLYEYFPLQRTPPRLRISVIKQRGIVKYLALHNPSNNEILCCDFDKNSVVSVVIRGLDPVNSIMVRSLESSGIVVFYQEDRSVLALLDFNTSKQYTINVPVRVSQLFVLEPGFWILQDNRSDKRFMMYSNDACPHGLPLVMEQVDVKGVAENEPFRFAQLAHVESPVGRFINSGAAEHFASVAVDFNSKTLASQSSAVSNIHTYMRRNQLDSKGDLYSNVKSSSIYLTGSKQFAVVHPFRDGRSEGVLELINAEQNRGWRVNIPLAYLGQPASEIPTVGFARPPATKLAASLCELPNGNLVTMDNAGCVRVWQVDSADLFRAAQTWKRMVGVDQKVLSVIFEKEDDSNNGEKSMAAEGSGADGEGGSGSGSGSGSGEGEGSGGSGGSGEGGSGGSGGSGATDMNENGREATFVDVDTLELRTASDKPNDVTEAQREMHEQAIAKRLEQINMTQADSKLFQTYLDNVRREVRELRVILESIEAKNKERVWLKNQTSGDLDDTKIIEGLTGEHNIYKKRGDDDPEIGLFQDKPKKMNFVFDLSASMFRFNTHDRRLERSMEVALMLMQSFRGFEHKFQYRILGHSGDGANIEFVTEGKYPKSEKEEFEIISKMRAHSQYCLSGDNTLGAASHAIKNIVKDEADDYFVVVLSDANIAQYNIKPSDIARTEAATCIQHSDPLNPSIYTVANCSSGSASYKSKRDELSYSGSSMFRVTFNCLSIDEKQCAMAKSSFIKAGQVISSVIRFQQPVTVNATFMSFCTQLGKCPDQNGGKTIVGSAYPAVSHMMTDSSDNMTRMYPQALLKQFRNLEETPSWASVDINAKFNSDANWYMDGNGTVGKHQVDLLRTVIHEYMHGLGFLNSWNNYLWTTFQQIDADCQQFLTPMPLSPPNQLQSVYDNAQEVNGPQPFWGFVEYPLDKLVNIAATNQPLSNITPKLNAWGNSNVMFASLTDMYHSWQGTNAITFAYKIYNLSTTADSLAIYDHNFGNIILETSLTPFQAGSSLSHFDNSLYDLSTDYLMVYQADPGVSIQQYMATRGGGPIGPKLLSIIQHLGYDLVNATNTTQPKLKPWQQPGNMVGTTDNPSPSVSYANAYVSTTAASQTPTATQASSNSSNSLSIHLSFIAVLLTLTFLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q234</accession>
    <name>A0A8H7Q234_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoporin NSP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Nuclear pore protein NSP1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Nucleoskeletal-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_000922</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nucleoporin NSP1/NUP62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q234"/>
    <dbReference type="OrthoDB" id="344345at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000040">
        <property type="entry name" value="Nuclear pore glycoprotein p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026010">
        <property type="entry name" value="NSP1/NUP62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007758">
        <property type="entry name" value="Nucleoporin_NSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084:SF0">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05064">
        <property type="entry name" value="Nsp1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin NSP1-like C-terminal" evidence="15">
        <location>
            <begin position="260"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="66"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="214"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="342"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="91"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00078941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2185009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="470" mass="48169" checksum="667FB7DB9D6D4869" modified="2022-01-19" version="1" fragment="single">FGNQGKPGGFGFGGSTGFGSNTTPSFGSSTPASGNTFSFGGQNTTPATSAPAAGGFSFGGGNAAASTPSFGSTTPAPASTPSFSFGGQANTTPAASTGGFGSTTTAPATGSFNFGQQTSTTSTAPASTGFSFPTASAAPASTPFGATPAASTAPASSGLSFGQPSSTATNTTASAPLFGAASAAPAPTSSAASGFNFGQPASTPAASGFSLNMTSSSGSAATSATAPSTFAPTLTTNPTVSGAPSAAAPSAAATTTQPNKPVTVPTPSSLKNKTMEEILNKWTKELDSYSSEFHRQAVEVAEWDRELIQNGSKISNLNNDVIKTEALQGEIDQSLSYINAQQEDLSSILDAYEKQMKEVLDQSNLQQPMQPADVQREKAYTLAESLNKQLDDVSRNLNIMIEEVNKMNGDEQSVDDNESEDNVSQIVKILNAHLTSLQWIDSTTITMQNKMQEVNKLQEKIERDQALLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q241</accession>
    <name>A0A8H7Q241_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q241"/>
    <dbReference type="OrthoDB" id="2236537at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF190">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="29"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="462" mass="52133" checksum="FA449948BB673BD0" modified="2022-01-19" version="1">MIQTLKNQLLQQKRSSDLQNHNDHNGDAPTKWTKFPDDVVYLIFSSLPFDSLLLCMRVCKHWHTLISTSRGLWQDIVVDDAAAVITTSDFRLYVSRAGKNGIRTLSLARPVGLFSLDTNEAISILLQHGVSHLRYLDISCWRLLSTPTILRLFESANKTLKHLNISYVNNGDDFLTHAVRTCQNLEYLECHGCYPVASTMNTLTSVKTFVWSGKISPQQSIVSLIRPFPSLENASFDCSCRQISLRLGEFILRLPKIKRLDIHIYSRLHYIRRYVDPPGPLDDDALQKITSNSHNLEYLSFSSFLDTDAGDTQIQAVLRGCSSKMQSLKLSRSSISDETMLYISTVSLPQLRELKLANCRRISGASLVTAIRACPNLQSLELLYVPAVDDRLLEVLGQSSRLETLNIGFSDHLTGQGLRLLLDKSSTLRRLRMIGCRNVDSDTLKYTKHHLGEANCIFDSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q297</accession>
    <name>A0A8H7Q297_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_000516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q297"/>
    <dbReference type="OrthoDB" id="10556873at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2184607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="208" mass="24128" checksum="2C299547F02085B7" modified="2022-01-19" version="1">MTWEDTYAQNMLVPTNTWAWSDRVMVIGTAPPRTVLTDATYISDLEQDHNPLLRWVDSITRSRNIAYLAHLLQDGIDELPPYINHWPTMECDNWGDFRRAVTFADIREADRSLMETIASLHRDVIVMVGRRPTLLYPHNHHSSYFTDICPNIDVYWFQGGSCGLVFWWLDPGLRRHATQTNALLIEHILQLSNSIAYCTSEDSFGFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2K7</accession>
    <name>A0A8H7Q2K7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="10">FBP aldolase</shortName>
            <ecNumber evidence="5 10">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_000671</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 10"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2K7"/>
    <dbReference type="OrthoDB" id="35652at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00946">
        <property type="entry name" value="FBP_aldolase_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000013">
        <property type="entry name" value="Class II fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006628">
        <property type="entry name" value="PRK09197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559:SF0">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2184758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="358" mass="39612" checksum="CED29FCC327AFB53" modified="2022-01-19" version="1">MGLADIVPAGVVTGDNVRKVFDYAQEHNFAIPAINCTSTSTINAALEAARDIKSPIIIQFSNGGAAYYAGKGLSNDGQKASILGAVAGAHYVRQVAKAYGIPVLVHSDHCAKKLLPWFDGMLEADEAYFKEHGEPLFSSHMLDLSEEPKEENIQTCLKYLKRMAPMKCLLEMEIGITGGEEDGVNNEHVDNASLYTQPEDIWDIYKAFSEVTDLFSIAAAFGNVHGVYSPGNVRLHPELLGKHQAYVKEQLKTKDDKPVYFVFHGGSGSTNKEIQTAVSFGVVKMNVDTDTQWAYLVGFRDYMEAKKDYLKAQVGNPEGEGKPNKKYYDPRVFVREGEKTMIKRVQEACKDLNNVNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2T8</accession>
    <name>A0A8H7Q2T8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_000820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2T8"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="5">
        <location>
            <begin position="15"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="393"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="318"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="352"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2184907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="452" mass="50939" checksum="5C5B1A2B7269ED7D" modified="2022-01-19" version="1">MSWKGLQKAVSRLPHQILSKKGDVTRDPEFAALERQFKDVSKVVERFQTDAEAYRDGVAAMLNHQASFSEYLAILYQPLEAETEDGVVKRRNNETSAKDIQAVQDYSTIMGYSRDEIMPWLDVIDAQVIGRVIEFREILKGVDRTITKRNHKQLDYDRFRTSVAKLKAKAEKTISEEKQVYKLEGQLDIATQDYEYLNGLLKEELPRLLQLRTQLIDPMFENFYFVQCRIYSMLLARLQEVINTNGDHFETINMGIEEGFNERLNRYNARTELEESGLLKQALTINYHRGISLLTVIVTTASAANSSKLTLKERAAIRQEEKMKGSPKLGGGGYGSSGYGSDSPPPPAYGMNQDSMLDSSPYQGDTKHSPSYGSYNNTYSPPSGHSPQPSTSGQTTYVTALYDYAAQAEGDLTFTKGDRIQVVQKTQDVNDWWTGSLNGQTGVFPGNYVTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3A6</accession>
    <name>A0A8H7Q3A6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3A6"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2185036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="322" mass="36487" checksum="F4582202B30BCB63" modified="2022-01-19" version="1">MKRRGPPPPGYAPPYHGHAYGGPPRDWDGPRPYGRRGDYLPPDPRPYKRGKPTPIPSPKPVRKDFFEFRLEKLIIGEYSADTGENNDGEDRLRFYLKDSNNNDSKPDSIALTVKDGQQRIVIDASNIKTIELLQKIGHFKFTIDGNYKIEKLENANFVECEEDPTDGQLSNTETFECYVDKKNPITTARETEPNIKNWSSASSRFREILQVLDADAPRTLDDVINEWAKTSPIGLPSERLLFAKMQLKKGEKLTEIITTLAHEESSVGPAVDMLLKNFKQLAEDKMSQEELNVHIKSMIMAMPESAIAKSLDIIWAIESEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3I0</accession>
    <name>A0A8H7Q3I0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_000783</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3I0"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="270"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2184870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="332" mass="37484" checksum="E3066FF2FEBB7445" modified="2022-01-19" version="1">MTEMATKQNKEEPLCHATSIAVENAIKRVETMAPINLTFFTRPMNDMTVTRIKQLESLYACSRITRFLLRKGVHPIGLFTVSTAALALAVRRLYRQSSYLIINTLGVAYPTWQCLKLLRKTEEQPNPSAQMNADEYKSWLTYWLLYGSLQVLDNWAPLLCDLMPYYNIYKIVLLYWAQNPQSKGANVLYHVLKPIQAQPSPIETSPIDIPQPYTLSKSMSIETIVKQTTESVPTPYETQYNSTGYANSFHDENDEELTLTISSGGPAYGLMNGYTPSLSSEREDETDGEDETDEEDSPDEPLVQSNHSSISALSASPKYNMLMHVANETPAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3L3</accession>
    <name>A0A8H7Q3L3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3L3"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="33"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2184915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="438" mass="48893" checksum="4B0CC27588FAEF35" modified="2022-01-19" version="1">MPSKDDVAIDIEIDPSFTGILYGLADDESDGCIVKGNCILHVAKPLKIRRLFVSLEGKLRVNLKPPVSIAPASEGVETRTLISKHKHFHGEDGNTKILNPGDHIYPFEFELPSTLPATFVSKHGRITYRIRTSIHRPMFNNDITAKKAIVLRRCLMSEFASIDNTECIEGVYEELMHYQATAPDMTYREGGLIKLNLNFDLLRPYSSAIREVSCALQETIHYRTTGVQAVNAHASSKLDIQLPLGVSTFFPSKAPDYDSSETHDYNAVFRVCPRVNADTNTKLLKVTHKIVVKVSIEDRSVKDFQKPSKRKVKSAPTTPACSDNEEEPEEEEVHSSASSIRSTSSSTSTSSMVLPLTLPRPKTFRHRSHNQSASYPIRVCQIDIPLVITSREHVWEGEMPTPPAYETEECPPTYFNSVIALPPVPDYENQLSEAITAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4U9</accession>
    <name>A0A8H7Q4U9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4U9"/>
    <dbReference type="OrthoDB" id="2425329at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2185846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="170" mass="19079" checksum="ED41D957BADD145C" modified="2022-01-19" version="1">MTFSYHKGTARLEEFSTKHELARNFYDDDEFCPIPSQQLPQVHEHRDRIRSRGSPGSSPSSSPTRSNHHGSPLRQSPRTRAVPIVDPSKRAVFNVAQASTNTNSNNVLYSGHVQESHHTTSNLAASSWAPPSRRYGIPIVDPSNGHMIVPNAHTSYQHRHQQTGYYVSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q588</accession>
    <name>A0A8H7Q588_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bacterial surface antigen (D15) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_002561</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q588"/>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="6">
        <location>
            <begin position="156"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2186123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="494" mass="53899" checksum="3A3E3D5D808D312E" modified="2022-01-19" version="1">MHRDEIDRTSCTLMEDDKAHNAAGVPPPPSYEEAAFRMFGLLNATASQPAHLHSLRVLGTERTRESFLKNVTASTFAGMTVADVINNVQDTAEKLQRLDIFDSVNVILDTSRDPFAARDALDCVLQVKEKSRFFLKTGTEIGNGEGNMNGSITIRNALGGAEMLETSASFGTRNSSAFQFSLSRPVNASPDARVDINAHSVVRNNMMFSSHEELARGVGARFKGLSNWGYHELSYDVSWRTIDRVAEHGSLRFFCMPCSIRNQAGHTLKSSISHIFFRDRRDDSLLPTKGYHLRLTQELAGVGSLGDTKYFKNEVEASTSHQFGGGELLHDEDGNIKAIAPGYVLTLSARGGLLATLNDKEASITDRFMLGGPLSIRGFRTCGVGPRDKKDSLGGDAYWATGLSLITPLPKLADKPLRGHLFVNAGTLIPWKTGTSAADTAQALIRSPSVATGFGIIYHHSVARLELNFCIPLTVARGDQFKRGFQLGLGLNFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5Q4</accession>
    <name>A0A8H7Q5Q4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_002734</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5Q4"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="36"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2186296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="527" mass="56838" checksum="CAB37B1310E61F97" modified="2022-01-19" version="1">MDIEKESSFKDRNMEELTATSPEDKEPGSRRKLTLIMATLCTLSFLAAFDNILISSNMPVVAGAFNAFNLYSWPNTAFLLTSATVQPIYGVCASIFGRRRMLLLFAIVMYQIGTVLCSAAQSMVMFIVARAFCGLGIGAFDTLMKIIVADYVPLRYIGRYQSYLGACWSLGYIVGGLLGGVLVSQTQTGWRSIFFLILGVAFIGLFLTLVSIEEPVRNTVSINELANVDLVGSAIWCISIVCIVLALSWGGSTYPWSAPSVVALLCVGGIGIFIFAIWEIKFAKQPIIPKSLFTNRSTVAVLVAAWLYGGCFQSLMTYVPLYLSVVRQEEAMATNLELLCLVLVACISNVLTGLIIVKTGRYTWAMRSSLVVLSIACGLLTMLKIDSSRGLIVGLMIVTGIGAGGIINSEIITAQASVAYEFVPIITPLMTFCDQVGGIFGIAIAGSVLNNKLYSNLAALALPNVSSALVRQSSAYVMALSEPARTMVLEAYANAVDTSYWGSAAFAMVALLATLLLKHYKMREGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6Y9</accession>
    <name>A0A8H7Q6Y9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002826</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6Y9"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000001">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="7">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2186388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="136" mass="15309" checksum="459006A7351DD76D" modified="2022-01-19" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAPTTGGVKKPHRYKPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAIGALQEAAEAYLVALFEDTNLAAIHAKRVTIQPKDIQLARRLRGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q7L3</accession>
    <name>A0A8H7Q7L3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor Pcc1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_002664</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q7L3"/>
    <dbReference type="OrthoDB" id="10025739at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000005">
        <property type="entry name" value="L antigen family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2186226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="10257" checksum="42473A38622B157D" modified="2022-01-19" version="1">MSDSRVDQLSRHLEIPFPTPRLAEIAQRALSVDKELKGDQVKRSISVEDNMLKVDFDCISVRMLRVSTTSFFEMLTMVTNTMEMFDVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U6M7</accession>
    <name>A0A8H7U6M7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable acetate kinase</fullName>
            <ecNumber evidence="5">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_009042</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="5"/>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U6M7"/>
    <dbReference type="OrthoDB" id="67445at2759"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="ACETATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060:SF15">
        <property type="entry name" value="ACETATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="207"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="330"/>
            <end position="334"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2171381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="399" mass="43458" checksum="EA058E3A75F85E3E" modified="2022-01-19" version="1">MPSLILVLNAGSSSLKFKLFTHPKLELVAYGNVSDIGTDDCKFKGTVTKNSQKTEKSEKLDDHKHAMGTVLEFFEKQHICAVDDIKYTGHRIVHGGDHRTPAKITKDELEQLDKLNDLAPLHNSRAVNVIRIVLDKIPNSHNFACFDTMFHQSIPEYIYTYPVPQDAAKAQKIRKYGFHGLSHSYVSQEAVKVLDKPLDKTKLITLHLGSGSSVCAIEHGKSLDTSMGLTPLSGLPGGTRSGDIDPSAIFHFVADPSHIEKEHLSRAERVLNKESGIAAICGTSNVAEITKRTDKDAKLALDLFANRIQNFIGAYFVALQGADAIVFTGGMGENSDVLRALVVERLACLGCSIDKEKNKSAASQLDNGPVDISGPDAKVKVVVVATNEEYQVAQAIIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U711</accession>
    <name>A0A8H7U711_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Polysaccharide lyase family 8 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_000048</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide lyase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U711"/>
    <dbReference type="OrthoDB" id="5980780at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016837">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on polysaccharides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.10">
        <property type="entry name" value="Polysaccharide lyase family 8-like, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038970">
        <property type="entry name" value="Lyase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011071">
        <property type="entry name" value="Lyase_8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012970">
        <property type="entry name" value="Lyase_8_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004103">
        <property type="entry name" value="Lyase_8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003159">
        <property type="entry name" value="Lyase_8_central_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38481">
        <property type="entry name" value="HYALURONATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38481:SF1">
        <property type="entry name" value="HYALURONATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02278">
        <property type="entry name" value="Lyase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02884">
        <property type="entry name" value="Lyase_8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08124">
        <property type="entry name" value="Lyase_8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49863">
        <property type="entry name" value="Hyaluronate lyase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034047820" description="Polysaccharide lyase family 8 protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide lyase 8 N-terminal alpha-helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide lyase family 8 central" evidence="5">
        <location>
            <begin position="372"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide lyase family 8 C-terminal" evidence="6">
        <location>
            <begin position="630"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2172701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="746" mass="79460" checksum="1F2861BAC7A0AA68" modified="2022-01-19" version="1">MVAYNTLLALALAAQSAYALERRATNTSSDVSTVLANVQQLSINAAAPPATSIWLTTLKSDGSFSDVDYTAGCNGNRANWGAEVHWSHVLDMTISWTTGLNGTSYKNSSSLLTSIKSAMGYWFTNDYTNEGCSMGNGGSTCPCSTPGLWAVNWWYNVIGVPKIAGPACSLLLDQLNSTEVAGCSRILARAYNIIPQETAANLLDVSIGGIYYGVVSNNATVLSTTFNAGNTGLAISSAHADGIKVDGSFFQHSGLLASGSYGPVMFQDFLNLQSFGMGTSYQATAAEQTAFTTVLNGSQWMIYSNSTGQNLWDNSVTGRSISRPGAATDIAINITQAIQATGNWSTAAEVAEISKAILKNTDDANDGPLNGNKMFYYGDYMVHRRSNYVVTLKMTSNRTLAEECVNAENLKGFHLSDGTVYTYLTGDEYRNIFPTWDWDLIPGTTIDYRGTPNNCTPAYYGLNSFVGGVSNGQVGAAALNFENPKTKNFSWKKSWFFLDNYYIVLGSNITETRTLPVFTTLDQRKLNGQVHVNGKVATTSNIQNAKTVHHDSIGYQIIDSGVTLNLSTAVQTGDWSSIGAYSGSESFSVFNAKIAHQTTAGQAVTNGVIGMVIYPGISYSTFAKQSVPATIIQRDSNAHIVQASGSNFVGAVFWAATNATAPLFGNAGTTVQVSHPIILSTTGSTLLVADPTQTLSSVQIKITSSKSIKCPTTSSFSCSTSGSTTTVVADTPEFMAPTSIRTNITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U803</accession>
    <name>A0A8H7U803_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_002944</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U803"/>
    <dbReference type="OrthoDB" id="427368at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="5">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="6">
        <location>
            <begin position="137"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2171322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="302" mass="34597" checksum="BDD19A1ADEECD448" modified="2022-01-19" version="1" fragment="single">MLFLGDRNLECIVHNTEKLETIQKSPVITSPGSTVKWIGFSETSASLPAVYDSKGVLSVLFKQRRPDQATWVPIFDGAKAAKDRGLDEKYWPVGLLRDQLMCLVLKGKIEYPYFPRPIISNIELQIPFLHMDAETTKLEESYVRNNVMTTHERDEATATSQQDEFHGILNKADIEMDKTLLRLIQMQLLKLQAIIDYRHWLKDLIKSKRTNLCRPLMMIYPHPLRANRSAKALGKSRARSLTQTFTTILIFSSSNSSLSSQLAFREPVPSLFSPSVRNVRLAQRKRDQMLSQDTDNDFDEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U854</accession>
    <name>A0A8H7U854_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_008243</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U854"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF1">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="608"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="555"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="338"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="451"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="869"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="404"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="878"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2171517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="902" mass="102270" checksum="633CFEFBE250E1CB" modified="2022-01-19" version="1">MPYKAEEGVPTPYSEFEQVKDHSQRPTEHSDILERYTDDEKKMLEEQQEFRTTPEQADKIHNRTEDVDDRLYEKDIHDPETGYEDPNDTDGETHHADEFDWDKVDDADSVLEEEKEAPTTTKIGNSALFKCLQSNSSSISWVFNIILGLILIGVAVIIHVIYDDLRRDPTSPSLPVIAIHLELWFTWLAFMWVISVAMHFLVEVIPWFIKTVIKLIMPTTSEITRMRLAYYHALKTQIKLILICAWGWGAWAFLRRVPTNLYVSPWVSVFDYTRVLQIIWECCFFLALMVFIEKFILQLIVTAFHRKAYSNRIAHNDYALTVLDKLKKVRRTVNYGKGRKNKSAFNTGSARTSFDSSKHRDSNSGDDMGSLAMGKRKNRSDPGSRDEPKSNVHFSNNSDTRIPIPDEKSPEFKSEKENENYDENKYSEKRPEYHSRGSSDFFSAVSHKLKRVKANQDKDGQPVRQRPEIKRLSSRSSTFDSARTLVHGGKDTALAIPNLIKSGFNIKSVYSTILPPSGTSQEQAKALAKQIFSNLLPSGTDRPYLVEADFYNYFRTKEEAAKAFALFDKDGNGDVSKRELRNGCIRIYKERKLLSASMRDLSQASGKLDMILLTIAVVIWAVIVCACFGINVGTSLMPLWTMFVAVSFIFGNSAKDMFESIIFIFVLHPYDIGDRVFIGTENWQVKSMGLLMTTFLKWDGTIVYVKNSILAPLYILNVSRAGSMGETIDIHLHFKTLSWKIDAIREQMTEWCNTEAKGLTYGSHGMNIVTYDQLNKITCTIYIEHKQNWADGGKRWATRNAYMMKLKEVLETLEVNYALPPMPVTTRNDAPDELYNFGSKTGYGTEGLASASSSDSALNYRRGYRFSEKGQSNMLDGGSSGGGAQGDSGVGPASAFVFASQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U882</accession>
    <name>A0A8H7U882_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U882"/>
    <dbReference type="OrthoDB" id="2414505at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="162" mass="17999" checksum="CE9109DF89C87B39" modified="2022-01-19" version="1">MRGAIVSIFLTVVGLILAPIIIIGLIILAVIAIVISTLTSSFILIRLMLLLLGVISSLTITSSNWLLSSVVHTLGRHMWGWSHQPNQSVIHQRILEQQKVSSSLARRRRRSMGKLDIPERYAVKNRRSISNPGTPIGHRVNYFDTATNIGLEMTRPQIVSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8Q0</accession>
    <name>A0A8H7U8Q0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8Q0"/>
    <dbReference type="OrthoDB" id="2403564at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="152" mass="17079" checksum="60A0BE4DD32BC717" modified="2022-01-19" version="1">MKEASTSKRKHSDEPPESPPSKKLAVEEPDVLSQLTTILDQITSCSTEIPALYLSTLKSLMQQIEGDCADESNTKAREVMEQSERFLEEWFENLVDRYGADEEFIFDESADEEDQLAIALALAEEDEEDEEVDIDSIHNSPTENSPNQPVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9A0</accession>
    <name>A0A8H7U9A0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_004525</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9A0"/>
    <dbReference type="OrthoDB" id="2020758at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02662">
        <property type="entry name" value="Peptidase_C19F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="23"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="496"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="517"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2173152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="534" mass="59994" checksum="FB20B73D95057219" modified="2022-01-19" version="1">MLHAVDEKKVSTDLCLTRPLYISGLVNTGNSCFLNSVLQALSATESLYPFLNLIAHAKPSTPVTSSLLYTISLLSSPSRRRTCFRPRHIVRAMSNHRRVINREQQDAQELFQLLSSAVNEEERTVVQFDHSHGLSQVLLDSQSTKSPKFGTAQKHGAASNPLMGLSANRLSCLKCGFTEAIRHFTFDNIQLIPPSTVPSITLQQCLAKYTAMEFLKDANCRHCSIHATLNQLQKEKATLSLRTKQIKDRAEQRKAFDRIVKLDQQCRHLDDRIRNGRISEEYDYEDHIRITPTSSQGSSKQVMIAKPPKILCLHISRSAFHEFGGLQKNMCQIVFPEILDISAYCTTGVLNVHPDQPISQQQASSPNGKLLYRLKSTIVHYGSHSYGHFVAYRRLPCQCGCHDCASHDDVWLRVSDEKVDRVGLYDVLHANPYMLMYEAVTSEDEPIETPVETAVNEIVTEPEELPVEDPPVVFNYSYTSESAKALEAIEIANSLMSHDQTTDTEPSSTARRRKNNRSNSHQVENLASATVTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9F9</accession>
    <name>A0A8H7U9F9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_009075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9F9"/>
    <dbReference type="OrthoDB" id="2353340at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034038910" evidence="1">
        <location>
            <begin position="20"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="200" mass="20920" checksum="95014407AFFB618E" modified="2022-01-19" version="1">MKLAILSAIVALSATTVSASSNGTIYVYADDIAHPKTTFLKKGSNNHLVTDGAACNGKKTLPGTGGALSGVLIDMPNQWDFNGAHDNEIRLGYIKVGKKCLTLTKGHPLSLAACPSFTEEVKVGNKFAWFHDSRSSACWAYGGDADADEDKGLTLAVQNLQTKGKTLNGVVIPDDLDKKAFIGLGSVNIGNAGHTPTGCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UA67</accession>
    <name>A0A8H7UA67_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MHYT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003279</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UA67"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152:SF1">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50924">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="3">
        <location>
            <begin position="14"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2178026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="803" mass="89283" checksum="E5BF9D5B2CA58B4E" modified="2022-01-19" version="1">MVPPLAPIYANQHFDAGLIVLSFIISVIGAQTTLELLGRRTSVKGAYNIFLLCGAALSMGSVGIWSMHFIGNNALKLSYHDATYQLVYTPGFTFTSLIVAIACMFISFAFVCSTDEVQTIRILLSGVIAGAGVVVMHYVGQFAIMFFALRYSVAYIVGAALIGIGATTAALYIFFKLRAQWENQWYKRLGCSMIMGLAVCGELLVIIYEVLDPNATPPVPPLTTAALIAIIASIVVVTCVGLLFIQVWQSKLLLKKQKTSQVALSAIYYDQDGKLLVKDDGTVPMKEIRTDTDKMDVNEVNVSSSLFATLFKLTISWESKTQLQKVSDNEEHSYFLDNFELAAYELANELKTAQNDLGCLYDGIINSGLNKKTSRLSFGNPFEKRSSEVDHSSVSQQSLQRSGKDSYRTSQTPTSSVFDISPKRYNRGKHLFLVRKLPASTTGNFTAQGYRFADPHYISQRMAAKLSVPEDYMLYQLLEMQKYADHGLRMSTDIERPISVSTNPGVWLGLVVLIEGLTPSQSFSILVDKEKRFSLPIVELKGEDVADRRGPLKPLEKAYLSRLRHTTMLDLVVPQSQSAVSREAEYAFVEESGVAASHFVRAFQQAAKTLATWSTYSHLIASKATLYHEVVETPAFSLASQPCQLILFTAYIISPEISASINASTTDLVKCLPLPLYKSIWEAATQESIQAYMKKRQLAMQSISERELYITPSRQSNVGYERRPTEDDANSLISLPPPPRMRRNRNRPEPAKLSQLLAGKSSKDKSTGEVYDMTEVFEMVPVLTTSERFQWLQNIIDDISEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAF7</accession>
    <name>A0A8H7UAF7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PABS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_001302</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAF7"/>
    <dbReference type="OrthoDB" id="38125at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.140.10:FF:000001">
        <property type="entry name" value="SPE3p Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000013">
        <property type="entry name" value="Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030668">
        <property type="entry name" value="Spermi_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002010">
        <property type="entry name" value="PRK00811.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558:SF11">
        <property type="entry name" value="SPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="SPERMIDINE/SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000502">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="12"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2175655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="295" mass="33549" checksum="F9AAB538B48EF450" modified="2022-01-19" version="1">MAAQLTHETIKDGWFHEKTTLWPGQAMAIQVEEILHVEKSLYQDVLVFQSTNYGNVLILDGVIQCTERDEFSYQEMIAHLALNSHPNPKKVLVIGGGDGGVLREVVKHDCVEEVVLCEIDEAVPRVSKKYLPNMAIGFQHPKVHVHIGDGFPYLEDKVNTFDVIITDSSDPVGPAESLFQKRFFELMKNALTHNGIISTQGECMWLHLPLIKEVQTFCRTLFPVVEYAYTTIPTYPSGQIGFMMLSKDKELTLRKPLRKWTPEQEAKLCRYYNSEIHEAAFILPQFAKAAIQDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAT0</accession>
    <name>A0A8H7UAT0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAT0"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051604">
        <property type="entry name" value="Ergot_Alk_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162:SF1">
        <property type="entry name" value="PRESTALK A DIFFERENTIATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="292" mass="32521" checksum="8173D836973F1472" modified="2022-01-19" version="1">MTISKVFVVGGTGNIGTALVKDLLERGVATTVLVRDPSKASKLFGDNEKLSVIQGDYTTLDVYKDNIVGHERLFFQVSDMNNMAKIKTTFAKIAYEAGVKQVVDVSSGSVSAPWRKNVIAAAHYYAEKNIYELPDRGYYVALRPTGFFSNHFFGDNKTVQFKGVLFGAEEPDHKTSWISPNDIAHLAANILTEPVEKHVDMVYDMTSVRASGNDRAAAISRVLGREIKYIQIPFGEAHKNFIDHAHMPHSMVYAFLESSNDYYPVNPGLATVLNREPETLEEWFTTNKNAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UB02</accession>
    <name>A0A8H7UB02_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_005474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UB02"/>
    <dbReference type="OrthoDB" id="62853at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05162">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12550">
        <property type="entry name" value="HEPATOMA-DERIVED GROWTH FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12550:SF70">
        <property type="entry name" value="JIL-1 ANCHORING AND STABILIZING PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="11"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2176240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="486" mass="53315" checksum="78C9257BD824DC8E" modified="2022-01-19" version="1" fragment="single">MAPKVTPEYTPGSIVFAKLRGYPWWPARVEDDTKLPSKVKQQKSKTKGPMWTVFFFGSKDYGFFGPDSIRPFDRSAVERDLQANKFKTKDLTEAVKQALDPTEFDKEIKKLKEAQRKEEEGGSDEKNAKSKKKAAPTKKAPSPPAKKTPVPKAKPAPTKAKPTPVKATKPAATEKQPAPSIPATTTLRKRRGTQKVYAIGYYWLTQLVWEISSLTLLSFAQRITEPTEEPKQKTNGKQKLDVLKKVVAEKKQTKPSPEPASGKENAEAKKSKKLYHLRHKLQKLVYEKKEEEISVEDYTKIDAVLNEIEALQGEVTYDILKETKIGKVMKNACAHTFPNDSKYKLKDRCLHLMKKWKTVLLAGAAEEKDAHGSKKPGKPSEAVSKNGQSTASSVTKDSANEEAVTTKPEIQAVPNDKVLAATAEESAAAVSAGLEVAPAIQDNMGKEGETKVDGDTVMLDSSAIELASAVVSQAPSAMDLGDDPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBM0</accession>
    <name>A0A8H7UBM0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_005052</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBM0"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="513"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2173634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="59572" checksum="92AA8F817FAFB368" modified="2022-01-19" version="1">MSRRESSVQVAPAAFDYSDRESLSSTATVSVHEVHGKGTTNGPAREPHMGLLTSCNMIVGLIIGSGIFASPGPVLLKVVSVGAALCIWALGGVLSMMGALCYAELGCMIVRSGGEYQYLKASFGRCVALSFTWSNLVLSNAIGTASVAIVFAGYICNMAYFNAADPSAAAKNVPAYETKLVAIGCIWAVVIFNCLAQRAGSYVSNIFTGAKVLALIMIIIIGFVWLGKGHVSSFENSFEGSSTNVLHYGSAMYLALFSYNGWNNLNYGISEVKNPEKNLPLAIIISCVSITVAYILANIAYLAVLPVNTVATSTTVAMQLGIAVWGTPGAYIFALMVVLSTFGAVNASIWAASRVLVAAAEDGIIFPRYFNHYHQKTQAPVRALILTGIIGSLWCLPGDYTYLANIYSFIGWLWYGITIAGLVYMRFKPDMKHVHRPFKVWLPVAIVFLLVDVYLVIAPLVEAGSAGITQYAICIVIALFSVPVWFIRVHKPAIGRKLLGWIPGYEDVELDDDQDYSKGAGADQDTRYDGSEKASAGEHNEHKNHASHSLQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBN0</accession>
    <name>A0A8H7UBN0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-tyrosine-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_007629</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBN0"/>
    <dbReference type="OrthoDB" id="273181at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46274">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46274:SF6">
        <property type="entry name" value="TYR_PHOSPHATASE_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="77"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2176975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26946" checksum="E70E27B9CD7FFFE0" modified="2022-01-19" version="1">MSKAPPKFTSKNSSLGISRVLEDDQPKQTGRTASLPTEAFKEPSEHASCFSWTGFILSLYFNKVAVHIFGGLTGWRWYTRIDECLILGALPTPPQIKKLHQEEKLHTVINLCAEFPGYRSLYEELGIRQIHLKTADFTVPSFEDIQYGAAILVDAAEKNQGSIYLHCKAGRGRSASIALCYLVRRYQLNPQQAQNILVKARAQVDKELHTAEQIRMYYKTVIMESETGKITRIPYTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDK7</accession>
    <name>A0A8H7UDK7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_001894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDK7"/>
    <dbReference type="OrthoDB" id="3363059at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029321">
        <property type="entry name" value="INTS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28608">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28608:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14750">
        <property type="entry name" value="INTS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2179045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="303" mass="34207" checksum="5BA9EC56F2BDB2E2" modified="2022-01-19" version="1">MLPWLITWFVELDGNNETESLEPLVKCFIYLPTRVTLLNGLISYDEATFALIVDTLLQAASTGSSQLNFHISESIYTLVQQFPKRALAVRFKLVQAQILPELALRLTISHIHDDVDFLNGEFTGLPSWILSQSSKVAPHIATMKNHLCDMAMKEVLSVKGVEDADQLKLEKLLRAIIGVLGLFGIKATEEQFRVCLQVIRKAQTARSIELSLCFVLICAEQVLRLPLRERNALMKYVCETEKTEVPALIAIAFASNQILQVETLVRQKLNMNLMIPKLGLFEMQKLFKTLETDIYAKFSAPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDY0</accession>
    <name>A0A8H7UDY0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Urea transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_003265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDY0"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000006">
        <property type="entry name" value="Urea active transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF4">
        <property type="entry name" value="UREA ACTIVE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="591"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2178012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="663" mass="70635" checksum="6064B24B372D325B" modified="2022-01-19" version="1">MAVLSQGVGYGVVIGLGALFAITMSLVTKALHRYLNENQQSSEMYMTAQRTVKMGLTASAIVSAWTWAATLLQSTSMAYKYGISGSFWYAAGATVQVLLFAVLAIELKKRAPNAHTFLEIVYARYGKSTHIVYLCFALATNIVVSAMLLLGGSAVVSYLTDMNVIAACFLLPVGVIIYTLFGGIKATFLTDYAHTAVIFIIIISFVLTVYATSPLIGSPSKMYDMLVASAQASPIPDNAQGSLLTMSSLGALIFGIINICGNTSTVGVDQAYWQRAIASHPAYAVKAYLMGGLSWFAIPFGLATCLGLAGRALQIDISASDVSAGLVLPDVASRLLGPAGAFASLILVFMAVTSASSAELIAVSSLLTYDVFRTYIRPGASGKAVIRFSHSIVIGFGFFMSILAVILRATGVDLGYLYTLMGVLLCPAVAPLMCTLLWSKQSKLAATVSPIIGLACGLIAWLVTAQGIYGEITLESTAANYPMLAGNLASIIVPIPCLLVLTWIKPQNFDWESTKAIQQVADPDEEDNKNTISIPIEPKPVVVEETPEETMAGLLKASRFAKISSLVLTLVLVILWPLPMFGSQYVFSREFFTGWVVVSIIWIFCSTCAVAIYPVIESRAAIATVFKGIYQDITSFGKSESSPQGTSIASSGDQAEVILAEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UE07</accession>
    <name>A0A8H7UE07_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_007138</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UE07"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF77">
        <property type="entry name" value="SERINE THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="58"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="400"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="416"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2182211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="467" mass="52152" checksum="1ABE699D12E553F7" modified="2022-01-19" version="1">MINATPTSPPASPVSSVSSASNSTNNAKRPARPPSVVVETLHATTSENSAGQKRINQYTLEKEIGHGAFGTVHLGCDTDGYYYAIKEFSKSRLRKKEQSDMLRRAGPRGRGRGRVGLGVGRAAASATVQPKNPLDFIRGELAILKKLHHNNVVKLYEVLDDPNDDSMYMVFEFAEKGVLMDIDLDKAATPYSEDVCRDYFIQMLLGIEFLHHNEIAHRDIKPDNLLISKDDVVKIVDFGVSEMFVKGNDRLKKSAGSPAFMAPELCVARHGDVSMVATDIWSMGVTLYCLIYGHLPFPKANMLELFESIRNDPVPYESNTNPELVDLLQKMLTKDPEERITLNQIREHPWVTQDGKAPLITVEENCQSVVTEVTEEEIHNAIKSVASIFTVIKAVTKFKRHSRSPSQQSMSPASDQEARKEPRTDLEVKSPRKEVDAERYHDAKEDHLSVDGLESHARRLSIDESRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UG10</accession>
    <name>A0A8H7UG10_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UG10"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="167" mass="18013" checksum="9615EA58837D22BF" modified="2022-01-19" version="1">MAEFKLKNLGFHTTQRLTSSINLGGKINQIGETIKYARESLSLWTATPLSSAPSTPTSLTPTLDKEQQKSVLDVPAPDKAIGKLTVNIVEARNLNISNPKSSRPYCLLQCDKNEFSTADGSGTSTSTGNGPSQSLAIPIPNAKATKLDPFQMAMQASCPKWQYEVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UG80</accession>
    <name>A0A8H7UG80_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Natural resistance-associated macrophage protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_001594</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UG80"/>
    <dbReference type="OrthoDB" id="409173at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00221">
        <property type="entry name" value="NRAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF101">
        <property type="entry name" value="MANGANESE TRANSPORTER SMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2178748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="564" mass="61919" checksum="9092D8D0D4EE0767" modified="2022-01-19" version="1">MLKTRSLLDNVKQTLLRFLRFVGPGFIIAVGYLDPGNWASDAQAGSDFGYKLLFVILMSNIVAIYLQYLAIRLGTVSGLDLAQACRKFLPRWLNFILYLLCEAAIVSCDLAEVIGSAIAFNLLFGLALPIGVAITAADVIIILFFYKDNTKSMRIVRVFEGFVMILVTTVGICFVIELVYSKPVAVDVLKGYVPTKELFTDPAMLYIAISIIGATVMPQYVSLYFTNNIIISYMSNSFRFNYSNLYLHSSLVQARCYQWKDSRPTSEEEIDLLESRKVLDAAIKTHLRYSFWDLFVALLFAFFVNCAILIVFSANFYYGPTQTSVGDLFTAHDLLQQYLGPAAAVIFALALLCSGQSSTLTATMAGQIVMSGFLGLNSRPWLRRLVTRLIAIVPAMIAAIVSGKDGINNMLIASQVALSIQLPFAIVPLVVFTGMKRVMTISVYNDSETSTCPDIAVDDDLLSERSKTDKSIKSRSHSTAPSSVHVCDATLDMDTVTEAPIQTASDIKKSQSIHEIDEASNNEIAPLVFANNKLMNVVSGIVALVIICLNAYLVITLFMGTASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UG83</accession>
    <name>A0A8H7UG83_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trehalase</fullName>
            <ecNumber evidence="5">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_006835</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="5"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UG83"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011120">
        <property type="entry name" value="Trehalase_Ca-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF6">
        <property type="entry name" value="CYTOSOLIC NEUTRAL TREHALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07492">
        <property type="entry name" value="Trehalase_Ca-bi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neutral trehalase Ca2+ binding" evidence="7">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2181910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="743" mass="85801" checksum="6D28D4734B855C08" modified="2022-01-19" version="1">MATQSTPEIEFDVHAPASTYYTTGDNSSTHGVGRNRSVTTFSRKTLDPSTGPKSISPRRRRASHDPKSKARKFLIDVQETQRLILEQEDTDGDFQITINDIGPKSLLLGTADSGGYRTIDVRGTYMLSNLLQELALANDYGRKHIVLDEARLNENPVDRLSRMIRYHFWDGLTRRIDAEGLEIICADPKNRSANHNPRIYIPWNLTEVYEYYLQAALARPHLKLEVELLPRDITPEYVKSINDRPGILALAMNRTVDKDNNVNFEGVPFVVPGGRFNEMYGWDSYFETLGLIVDGRIDLARGMVDNFSFEILHYGKILNANRSYYLTRSQPPFLTDMALKVYERLPQEKEQENKEWLTEAFRAAIKEYHTVWMSAPRLDKKTMLSKFYPTGLGIPPETEASHFDHIIEPFAKKHGVTIEEFDQLYNDGVIKEAELDEYFLHDRAVRESGHDTTYRYEKRCANLATIDLNSLLYRYEIDIGETVRDYFDGEFTDYDGIKQDPQDWFDRAVERKKRIDKYLWNEKESLYYDYDTVKEEQSTYDTVTAFWAMWAGCASPQQAEKMTENSLSKFEVTGGLVSGTERSRGKISLDRPNRQWDFPFGWAPHQIMAWRGFANYDMMDVARRLAYRWLYTITKSFVDFNGVVPEKFDVVSMTHKVEVEYGNVGVDFKFVPREGFGWMNASYQVGLSYLNTQMRRALGTCTNPDLFFEKNMTRLNELHGGVDELRRRNSMAAAKALSLAGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGH6</accession>
    <name>A0A8H7UGH6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="2 8">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_007107</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="8">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="2 8"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGH6"/>
    <dbReference type="OrthoDB" id="272370at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.110">
        <property type="entry name" value="Inositol-pentakisphosphate 2-kinase, N-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043001">
        <property type="entry name" value="IP5_2-K_N_lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2182180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="340" mass="39057" checksum="D7376EBD60EE7A4B" modified="2022-01-19" version="1">MTVWDASQWDYRGEGNANLVIYYTGCDHELVGKALRLRKIKCTSCSKAPQCQEDARTCVDTLQNVFKPLIGEEYTSNMVQSAVKLSQRKDVNELARFGLLGEDLLNSSVAVEVKPKWGFLPQVEGLKQKACRFCMHSHLRGSPSHYCPLDLYSGDRDRVRTALEALAKCPSNNYRVLVNTPFTDEALMSLMTEILTTDPILCNLVKLQMSLDEWDVERIWPLYEKHKHEVDDLTTDQWIQAVQNFKNGQCRDDPKQRIMEYVLSMTFKDCSVMISIGNSADKQIEWQLQDRWLSTSYSIKVIDLDLKAVHRIGHWYDLDQKIVKHAEESQFAPKCVKNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGI9</accession>
    <name>A0A8H7UGI9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_008426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGI9"/>
    <dbReference type="OrthoDB" id="5577714at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2180847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="53" mass="5894" checksum="F3A3A0E7B27681B9" modified="2022-01-19" version="1">MNRGPLVLSIDEAEYLLDQLPPPDKDEDALVSKLREKLSTLLTDLRKGAEGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGK3</accession>
    <name>A0A8H7UGK3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGK3"/>
    <dbReference type="OrthoDB" id="21418at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645:SF1">
        <property type="entry name" value="YALI0F12243P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="270" mass="30096" checksum="71C577A9EA3AEF04" modified="2022-01-19" version="1">MPDQHNYSQEQSNILDSYESTENALMDSFKAAALKVTTLYKDSLVQNRKAFAAGYQQALQDLYGFISSHPGVSVRNQQHEQMCAPTEQGLVPVEDLLNFARSKNAQLTYEVRGSSPLVEEQMQQEPASTANPNNAPNIPQQRFESARAPAQPTANQPPTQFFTPGSEQPQPTEPAQPPTASAAVKNAFHPFQIDPNTQFTFSVPSDAGNMRPPYADSLNMSVDNNQDVVMDGLKRRIATPEFTFMGRPFNINIDNSHEPPFKRVRPRRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGP2</accession>
    <name>A0A8H7UGP2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BAR-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_008579</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGP2"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="5">
        <location>
            <begin position="17"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="360"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="306"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2180997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="47809" checksum="0C22518CD3970816" modified="2022-01-19" version="1">MSWKGMSKAISRLPHQVMASKSKGEVTKDQEFADLERRLAEVQGHADSLLADAQAFRDGVAAMLSHQIIFSQSLTPLYQSNMGVAEAEDGVNKRRQTYLTANATKAAEDYETAMNYCREELSPEIEQLDYTVIRPIVELREILKSINKSITKRHHKMIDYDRYRTNLTKLQTKSEKTINDEKQIFKLEGQLQTATQDYDYLNDMIKQQLPYFFQLRSHFIDPIFQAFYTLQVKIYLSMWQRIHELIEQNPDHFETLQYGIEDGFQSRMQNFNAREQLEQLDLLAQGGKQWKGATSTSSRMTLQEKAAMKKDHGSSFGSSPNSFGRTYSSGSNEAETQPPAYNTSNYQPQPPQMPMRRPSPSANYVTALYDYEAQTEGDLSFSAGDKIQVIERKAPNEWWTGVCNGVQGVFPGNYVENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHY9</accession>
    <name>A0A8H7UHY9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IucC family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHY9"/>
    <dbReference type="OrthoDB" id="2117718at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007310">
        <property type="entry name" value="Aerobactin_biosyn_IucA/IucC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="IucA/IucC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037455">
        <property type="entry name" value="LucA/IucC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384">
        <property type="entry name" value="L-2,3-DIAMINOPROPANOATE--CITRATE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384:SF5">
        <property type="entry name" value="L-2,3-DIAMINOPROPANOATE--CITRATE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04183">
        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aerobactin siderophore biosynthesis IucA/IucC N-terminal" evidence="1">
        <location>
            <begin position="268"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal" evidence="2">
        <location>
            <begin position="457"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2182392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="630" mass="71299" checksum="0F1F1C7294E3A1E4" modified="2022-01-19" version="1">MPVPSASKTTHFAQFATTSRLLSCLVTEGLLHAYMQPLSNKDEMKAVCLIYYNEVAELRPEVIHSVIPLKGIPIIDTNDVNGLYKVELLDPMDMLPAIYTISSSLQSEYKDTTWIEHGYLQWKQATYNYLLSKLPGLSKSNLSDRIDGAGLWTSFAEKIKVSAPLVDQIAKELNSSIINQRYIYEHPRSLPSFKSSFIEWEQCVFEGHATHPVTIIPGQVGFIITTSRFTIPPMPSIEGDDYDLAHPNIRIAAIPRSSLILTGSFEKLLQPMMKIILEKTNNVPDSNHYALIPVHELQLPNIKHLFKDIIILPEDCSVQAQALTSLRSVVVPEIFRDLSLKLCVGMKVSSAMRTITPFTTYFGPRFSEHVVPRLTINKQILQIERELASACYKHDDFDVAKHCSCVVRDSFESRNEANGETVVVCAALVEKCQTPDSNVSLVENVWGLDTEEKKIKFLDRYIKLSLEAFLPPCLHNGVAFEAHGQNTLARFDSKTKELIGFTIRDFGGIKGHQETLMKSCGVKFDVLPDSCVIAEEIDGVYKLLYHTLIYSHLHRLIRVLGMHYNGLGWSILRRYLKAMIPQEHPLYKAWLLQSGIPGKCLMQMKIDELYRDDVQDQETKTQDATELLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIT9</accession>
    <name>A0A8H7UIT9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIT9"/>
    <dbReference type="OrthoDB" id="2358153at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="246" mass="27803" checksum="1255D93381635DF8" modified="2022-01-19" version="1">MHPRRGKNLPPNTVDSRSKRLSTSEPEDYQITIAWLEQHANERYRDVEGNLPPNISEFALCKAHSSSLYRARKRAELNMAQRDQQFPTSSQVSMSLPAGFVPTPSSSAKRKRAEEGMEDMRRMQRRASLSMANPYAEQPMGFGQVVETISLRSALTDQERNDPNIMPSGTYYLRNLAITDTFTFRDILREIDLTGTAPPGKKIVITNIENDRTYPMDIAIRSVIWGKPHAELCIGVQDVVSFNLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIV7</accession>
    <name>A0A8H7UIV7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_000673</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIV7"/>
    <dbReference type="OrthoDB" id="278280at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="165"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="165"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2184760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="349" mass="39931" checksum="71E860A56A2073C5" modified="2022-01-19" version="1">MPPKKQQTNAKTKKAVEDKTFGMKNKNKSAKVQKYVQQVQQQAAAGGKSKQATEKQKLKEAQDAKKAAELKKKEELLDLFKPVQAAQKVPFGTDPKTVLCEFFKAGHCEKGNKCKFSHDLNVARKGVKIDLYTDSRKEKEEDTMDKWDQKKLEEVVLSKAGNPKTTTDIVCKYFLEAIEDNKYGWFWECPNGGLNCKYVHALPPGFVLKSKKDKMEKKQEITLEQFLETERHNLGPNLTPVTLETFTEWKKNRMDKKDAEEAAKRKLKEKQFSAGRSQGMSGRDLFEFNPELAEDSEEEDYFDLSTYDREEAEKERDRLDNERRGLENGVSEMSINDDTAEGQGESSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJ58</accession>
    <name>A0A8H7UJ58_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_000988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJ58"/>
    <dbReference type="OrthoDB" id="10263222at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2185075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="487" mass="55247" checksum="40CF93C0C2DC5BD3" modified="2022-01-19" version="1">MPRIPRIVPWTSYQELEYVYNMLYFDGPEAEFQRDLGVQRVKAWKSRGKVPQAIEMTSTFIEVQLRDQFATGLSRISQHELRLMYTMSFVRFVNGIVDPAQKRQFAISVGSLAEKLQLPLWFVELRHAGTHEYLPSLQVLRNGARQALMWLHDFYWMAALKPDGSAALTRSSMAEIRNMLGTYKDARKKQLKEMKTIKSVESRECTKAIKKIISTVSIDVIRDGLIPVLIDIGGIVPAGKKKRPIHPSLALSDDLIELWAPLLRHLDMNYANFAEEFVSALLSKLTVDEEPVMDKTLLGPFPGFFDSVDDAECNPAHASASYISTIAAWLKHVIETTSKETDSGTNSVLLQEISMDDILEYCLKNPNLYTRHLLKVMTDADTKLKQTIEPFIDYIDNVLSERKKKKSTATHLNEEQMQEDLDLLSKQIDQSKGKTLYHDNDQDVEMSGCNSNGWSLFQESEWNVCPLGCLPDGSVPVLDLPIELDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJU1</accession>
    <name>A0A8H7UJU1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="2">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_002232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJU1"/>
    <dbReference type="OrthoDB" id="10264196at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000007">
        <property type="entry name" value="Pyridoxal phosphate homeostasis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2 3">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2185795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="237" mass="25938" checksum="E33515740B57974C" modified="2022-01-19" version="1">MTDRRADIVANIQEVRQRMQKVTPSGQQPTLVAVSKYKPAEDILAAYEGAEQKHFGENYVQEMVEKSEKLPRDIAWHFIGNLQSNKCKVVAAIPNLYAVETIESAKKADALNKACVQVSRENALNVFVQLNTSGEESKSGADPESCVEIAKHIVENCPKLTLYGLMTIGAPDRDTNGGENPDFVCLRECKAKVEEAIPGSSMQLSMGMSADYEDALRSGSTNIRVGSTIFGSRPVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7ULP4</accession>
    <name>A0A8H7ULP4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_002805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7ULP4"/>
    <dbReference type="OrthoDB" id="162638at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.60:FF:000001">
        <property type="entry name" value="50S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_bL35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_bL35-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_bL35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_bL35_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN BL35M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL35M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="L35p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2186367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="101" mass="11533" checksum="DAC8D3A4199947B2" modified="2022-01-19" version="1">MFANILKAMTSPMSGMSRPAFAMLSPMTMQSRFMSNKLKSHSGAKKRFFPVANGKFKRWQVGKRHINVGFSPERTNRLMGSVMVTKKSDKRMLRKALPYNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UMM0</accession>
    <name>A0A8H7UMM0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UMM0"/>
    <dbReference type="OrthoDB" id="5279943at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="269" mass="31417" checksum="B911B13C6E994CD4" modified="2022-01-19" version="1">MEDHKLGCPISASETRKPSVSFDLSNLPEKPEPETIVIAQQDNVAEPSSPIDINGHVVPDTILVALLDRDIEMKELASRNKSFFTMLESHLHESWSDFQRVLYTRREQIPDAEWIRQISVSLEHAPALFEKFKDLVGYEEYLFDSDSYDDDDEEIRYGSYDESTFENVDITLIRNYPSKLATFKQSYPQFFINAKHCFTEEEDQETKFGNHSYDAFDHLLFSSRRDMEDQEWENKIYDLLDKWPNLLAQLKEIVAYEVECEEGGIEEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCR0</accession>
    <name>A0A8H7PCR0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">INT43_009099</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX41 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCR0"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000449">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000657">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="191"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="386"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="575"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="588"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2171438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="606" mass="67652" checksum="F4D9ACCAE3F492DA" modified="2022-01-19" version="1">MSDSPKKQLDQDDDDKYVPYVPLKQRRLEKLHQYASQRRVPEPTTQPESDSEDDAPAAGPKAAISLLDQSAEVRRQQGLQEKTEEQKRLEEERKIEEAQARHKALISVQEAAAGMQYTEPMKTSWVPPKHIRDQPEQEHEAIRQKFHILLEGNNPVPPIKHFPEMRFPKPILDYLRDKGIHKPTPIQIQGLPVALAGRDMIGIAFTGSGKTLAFSLPLLMLALEAELKLPLIQGEGPIGMIICPSRELARQTYEGLCIMADYLAKGGFPHLRTLLCMGGIDMREQHHALANGVHMVVATPGRLQDMLTKRKFNLDSCKYLCMDEADRMIDMGFEEDVRNIMSYFKSQRQTLLFSATMPKKIQDFAMSALVQPLVVNVGRAGAANLDVIQEVEYVKQEAKIVYLLECLQKTPPPVLIFAENKNDVDDIHEYLLLKGVEAVAIHGSKTQEEREFAIRSFKTYKKDVLVATDVASKGLDFAEIQHVINFDMPKEIEDYVHRIGRTGRSGKTGIATTFINQNCSEQIRLDLKHLLREAKQRVPPFLEALEDPSEKLGLSGGCSFCGGLGHRIDNCPKLEQQRRQQMSSMTGGHHGGGGGGGSGGGGGGNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCU9</accession>
    <name>A0A8H7PCU9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_008281</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCU9"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="12"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2171555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="497" mass="55278" checksum="0898AA5B4689337D" modified="2022-01-19" version="1">MPNAGDWRMYLLCGLAIVNSATNGYDGSMMNGLQSLSYWVEYFNYPSDSTLGLLNAIMSVGGTIGVFAGPPASDILGRKKAIILGSTIMLLGVGLQGGARNIGMFIAARFILGFGLSITSNAAPTLVIEIAHPSHRGKITSLYNTMWYLGSIVAAWVTFGTLTIKSDWSWRLPSLIQAFPSVIQLMSVWWYEESPRWLVSKGRDEEALRILAKLHSNGDEQDELVQMEYREIRAAILQEKELAKRSYAELWATPGNRMRTFITFTIGFFSQWSGNGLVSYYLVKVLTSVGITDPFTQNLINGCLQIWNLICAVSAALMVDKVGRRPLWLWSTAGMLLFFTLQTICTAVYAEHNIGAAGTASIAMIFLYYASYDAAWTPLVVSYVVEIMPFTIRAKGMAVQGLCVNLALFFNSYVNPIALGALGWKYYLVYVCWLVLELFVVWKWYVETKGRTLEELAEIFDGDQAPLVIAEARRLEALGRENADGKEDIPVYDTEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCW5</accession>
    <name>A0A8H7PCW5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_008307</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCW5"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000135">
        <property type="entry name" value="forkhead box protein G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF1">
        <property type="entry name" value="FORK HEAD PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="105"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="105"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="239"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2171581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="461" mass="51352" checksum="E310E5394577478C" modified="2022-01-19" version="1" fragment="single">MKRRNSIAEFSFQLSAVPTHYCPSDSGSIYNTMAPETSVCYLRQPDEEVNNVPEESSNRVTTQPLAKRFPNRSLSDSVLVLKDKNCAAKPTSIIPSWKPQSNDEKPPYSYATLIAYAILSSSEQKLPLNDIYLSISANFPYYVLGDNGWQNSIRHNLSLNKSFIKLDRKPSDARPGKGSYWKIVDGQERAFIDALTRPGGPLRKQTVNVGKRTMSTNSRQNNASCENLLIMGPQDFEKCSKPTHSITTSLTSSEPVSLPDQPSPKAKPTTQDSSSPMITIFRMAPMVNDGYRPRRKSVKSQKRDHTSKPCSRKRRRTSITGKHDDHDSDCDSGVDVGNEFVPNNLLDEYQGSIDFPPFIKQQSTALAGDSSYLLDCLPSSDDLLLESSDLSYLADCDSPTSCTLSSFLDEPASPTDHTSFSIFSQQESTCLEPGYEFEENLLLTQSSSLYSQEEWSTNYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD43</accession>
    <name>A0A8H7PD43_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008084</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD43"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2171704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="156" mass="17269" checksum="923372BAAD667079" modified="2022-01-19" version="1">MQVFVKSLQGNTLALDVNANTSVDAVKALIQQREGLSAGFQCLSYAGKSLSDGQDLALYGVQNNSTLHLNAELLGGGKKRKKKTYTTPKKIKHKKKKVKLAVLKYYKVDESGKITRLRRECPTPTCGAGIFMAWHHDRQYCGKCGLTYVFKGQEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD64</accession>
    <name>A0A8H7PD64_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fructose-2,6-bisphosphate 2-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_008129</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.46" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD64"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000005">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="452"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="210"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2171749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="489" mass="55494" checksum="02BD4A4BE75FE0FC" modified="2022-01-19" version="1">MVGLPARGKTYIAQKVRRYLTWLGINTKVFNVGNYRRKLAGAHVPHTFFDPANSEGEKSRREAAAEALNDMIRWFDDEEGIVAIYDATNSTKARRAWLHESLSKKDIQVLFIESICQDEEVILNNIKDVKLSSPDYFDIDPDQAAEDFRARIDHYTDQYETITEDGLTYIKLINIGSQVIINLIKGYLESRIVYYLMNLHIAPRKIYMSRHGESVFNVEGKIGGDSPLSPRGEMYASKLPDLISRNLGDQNLTIWTSTMKRTVQTASLLSHPNKKQWKALEELDAGVCDGMTYEEIAEKYPEDYANRDEDKFNYRYRGGESYRDVVLRLEPVIMELERHQNILIIGHQAILRCIYAYFMNYSHEDLPYIKIPLHTVIELTPKAYGCDEKRFKVDIEAVDTHRPKPSRGASLRRKASTNLASKAPGSLKIPAPAGASGEIVYDPMSPILPITSPKLTARPSSTWVPTAKDQKSPASLSADMANLQLNQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDH8</accession>
    <name>A0A8H7PDH8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDH8"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="369" mass="41187" checksum="1879E810ABAF3C9B" modified="2022-01-19" version="1">MSASENFNLFKPIKLGNNVLKHRVAMAPLTRFRANDNHIPSEMAKTYYEQRASCGGLIITEGTIVSEDSSHWPNVPGIYTREQIEAWKGITDAVHAKGSVIYTQIWMAGRADVVPRFSASAIPITPEDGKEPLIPRALETSEIPGIVELFRQAAVNAIEAGFDGVEIHGANGYLLDQFLQSNSNKRTDQYGGSVENRARLLLEITEAVSNAIGQEHVGVRFSPYSGFQDMHDENPVETFSIITQILQDRFDKLAYLHFLEPRISGAKDKSEVGEEVGSETLEPYRKIWKGVFLRAGGHTVQSATAAAQQNENDIIVFGRHFIANPDLPCRLKNGYTLNKYERETFYSVGSPVGYIDYPFYQESQIKVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDV7</accession>
    <name>A0A8H7PDV7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDV7"/>
    <dbReference type="OrthoDB" id="2288800at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31639">
        <property type="entry name" value="F-BOX PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31639:SF42">
        <property type="entry name" value="OS02G0160200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="13"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="589" mass="66846" checksum="18F1CC0196DD676D" modified="2022-01-19" version="1">MWHQIVTNPHLHFLVMNTLPAEIIHNIFSFLPKDSLFSCLCVNKFWHDCSQSFLYEELELESPGDTCAIFTRLTNTYEVNGGLGKWVKSLRIVLDEYDLGISPVSELLSLCSNVERIYIHHLIYDDENYNRHISPDYATLLPLCSKLRTLQGLGEAVELIAKCGARQITTLELWTVLPLTAIEGLGGNFPNLVNLRLSLDIIKVAILEDLAINCPNLDTLHLTAGGQEPITNSHSRKITISFITTLNFDIEDIDRSWVAHLAHRYPKLKRIMTSSRGNNETIDFCEIAQSCSSLSDFTCKAYNEGYAPKASFFEMLSQSAAANNGLKALCLKGNRSLRPARGSGLRPTISFGDQDLHKAATCFGGTLCFLTLQCCDNITSAGFDAALDNCHNLTNLSLSTRTGTEMELQFLRLMCQCPRLETLKLENIEIACAPSSPPIDMQTHLKSVTFEKMKTWVVVFDHIFNYCPNVSYIHLRHLCLLDQKDTRIELPHHHIRLLTVYSFDIGSSEKECEYLVELTYKFRSDMTPRTHQFHCFCRCDRKRIRRCCYCGFSQKSIEDKDIVSKLTNLRIYIGQLDDHVVGPSHEDEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDZ6</accession>
    <name>A0A8H7PDZ6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription initiation factor TFIID subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">TBP-associated factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_001395</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TAF2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="308861at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09839">
        <property type="entry name" value="M1_like_TAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000011">
        <property type="entry name" value="Transcription initiation factor TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00512">
        <property type="entry name" value="Ribosomal_eS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057345">
        <property type="entry name" value="Ig-like_TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020924">
        <property type="entry name" value="Ribosomal_eS6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057991">
        <property type="entry name" value="TPR_TAF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25316">
        <property type="entry name" value="TAF2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25577">
        <property type="entry name" value="TPR_TAF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="15">
        <location>
            <begin position="1222"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="15">
        <location>
            <begin position="1415"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="15">
        <location>
            <begin position="1607"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="15">
        <location>
            <begin position="1719"/>
            <end position="1789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1143"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1508"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1992"/>
            <end position="2048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1147"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1164"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1187"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1508"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1993"/>
            <end position="2005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2006"/>
            <end position="2032"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2171919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="2048" mass="230796" checksum="3AEEC20D56F11DE4" modified="2022-01-19" version="1" fragment="single">GYAELSVLPLQPNLDSVQINFKQGNITHVTINGDPAQYTYKDPLSDVTMGPNTTIGNHQSYKGKYLTALKDADEGELKVMIPSEAIVQAKGDDAYLESATVLPTTINRGESSAPPTPGGPTITNYAPITIRIDYVLESPSAGVVFVEPDPVVAPYRDRHVYTTNQPMTGGTRLWLPCVDKVSERCMWDMIFILPQKMTFSEDDVYDESTNDVFQDDKKHSRGISHWQIPHSCCLQTTHPTDPSKKIVHYSLTVPTAAPFIGFAIGPFEMIKLSTEDLQLEIVADVDLGINQKQSAMTGINMMPDIYVFCLPGQVDELTNSASFLANAMHFFSQEYGTYPFVNYKLVFVEEAWDPVVSCASMSICSVSLLHPAEVIDQTYETRRVLSIALATQWFGVHIVQKVWSDIWLIVSLAHYMAYVFLRKHLGNNEYRLRLKKDMLRCVSLDVNRPPIFNSMLPAPLDQDDLDFIRLKGPLVLYILDKRMTKAGSTRGLSRVIPKILVEAMSGELTLNALSTHWFLRQCRKVSGHDTKTFAEQWIYGSGCPKFTFKYHFNRKKMVVEIDMTQENSSAASAPPTDVMTDVNNTLAFQDSVTTIFTGNFIARIHEADGTPYEHILDIQTSAKRFEVQFNTKYKRIRRNTKRFQAKQAAAAAAAAEEEQMEGEEGENTSSIVPSLGLGMPLFEEDQYRQEWRLVEWGQEEDDTSGAASATFDWIRLDAEFEWICTIKFEQPDYMWAAQLTKDWDVVAQYEALEALKTMPSAMTSTSLLRAIMDQRCFYRIRMQAATALARCALPDLNWVGLLQLTKIFQTKYCFPPHNEDAFVDPVLPMVQCIPRPNNFSNFVDYFVQKGIVAAFALIRDENGVCPPPVCKLLLDLLKYNDNTGNEVEDSYYVCALINALGDALLPISAVDPDLTDPKRKLFVETAIAEIERYRTRDIVIPSYHNIVTVNCLEVYTGLMLSGLMKTDLALFMNYSRYGNFEDIRMVAFDSILLLCGLSDNTILKYMFDITQFDLSPSIRHYVAKALLVAFGLMIRGNYSTSSAVEEFAEEEGRVIIEDAWRKRPNGLVEFHKAILDIRAVFSMNIGLQKYLWNTLNNHAAVRLDHRVLKYILQFCEYAYKPVDVGLKVTIRMPTLPAPSVIEDAEVTPSSSRTTTSPMAETPKAISQPSPTVSAPTTVAPVNKVNKPPKEPKENKLPKPKLPSDGIPLEDLKKAKRVLSKLLKHKASFWFRQAVDPIRDGAPDYFKYVKTPMDLGTVQTKLDNMQYKTLKEFENDVRLVFSNCYVFNPSGTEVYNEGQALEALYEKEWAKLNGQSRELNMTIVESPVQTPTEVVPSKPPAAEPIPAPSVNVKNSVAPAPVTPAATAAAAAPKPKPKPAAAPRPQAAIAKPTNGAMEAKKDKTDMEKCQAVLQKVLQNKLSAEFRQPVDPDLQGIPHYRQIITNPMDFGTVKTKLKKGKYANAKEFDQDCRLVFRNCYTFNPPDNPVFQLCKSLEKEYSKYWQQIFGNKSSTPESPAQAAGTATSSPKVTSVKLSTPQPPTQRPHATSVPPKVASSPVIKEEPRPASIGPETAAALSDNNKPVVSAPLDMTMNPLNYNKCEHILQKLSDNPAALPFLQPVDPVALGIPMYFDIIKKPMDLGTVRNKLTSHQYKTVEDFEMDVRQIFWNCFRFNMAGSWVEQQGRELEAVFHELYWADYPRPDMLNPTQHKAARNVLIKLMTHEAATIFLEPVDANILPNYYTVIKTPMDFRKISEKLTFPNYTQLDQLTADIEQIFTNCFTYNAPGVWGHNQGKRLQKYFHGLVSKDPLNIANPATGCQKLIEIEDERRVRVFMDKRMSAEVAGDSIGDEFKGYVFRISGGNDKQGFPMKQGVLLPHRVRLLLSKGHSTYRPRRTGERKRKSVRGCIVSSDLSVISLVVVKQGEQDIPGLTDTAVPKRLGPKRANNIRKFFNLDKTDDVRKFVIRREVQPKNPEKKPYTKAPKIQRLVTPVTLQRKRRQQALKRRRAEASKEAEANYKELLAKRVKESKERKQEIKRRRTSSMQKSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEA1</accession>
    <name>A0A8H7PEA1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription initiation factor TFIID subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_004858</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEA1"/>
    <dbReference type="OrthoDB" id="341924at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2172316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="23036" checksum="CA3D4BFDA17DF686" modified="2022-01-19" version="1">MNRQRQQQREAGQQQPRDAKIISLLLQSHGVHDFDPKVVHQLLEFAHRYTSDVFQDALVYAEHAGRQDIDLADVQLAVQGRVSHSFTSPPPREFLLELAQEKNKVPLPLIPEKYGIRLPHEKHCLTAINFQVLPNAPPPPKNLVNKPSTEDSNIPQRTLSEDADMPDYQSAGTPLEYSGQDNDGDAAEVPNKRAREAMEDDDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PF29</accession>
    <name>A0A8H7PF29_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PF29"/>
    <dbReference type="OrthoDB" id="2439595at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2172743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="498" mass="56522" checksum="0316C56FBA8B58E8" modified="2022-01-19" version="1">MLKAFSLDRNKADPEDTISSPVSAPPYQRSQSSGILDHHSRNQKILATDTNEPRPAPQPSAATILGKKLSRAKTIGGLRSTRPQHTMDEHYTHSPIEQDISPEDDQLRYPVTQKNTSMDSSHRLERTSSLVAGKDRQYSNESASPRNQHPVEEECNSDDRQNERDSSENGQDQARPMDAEESGPLEPPHEELLQQLEGYEAMLNRLQTDLELATIRNKDLNNELGQTRKLLQRREQEYARIEHNFFEHTKLIRATDDDLSTIRDTFKLLKYGITRFVMSLNKKADREKATEKFLTMWPNLPLSELGTPLEHGHINMLTEKLIHQHLVNLIFESPLYPGLHINGAYSEMNRWLQVHGSDFSTRLRQQLSAIIAKSKPDSETQQEAQAARAEIIDRVYNDLAEIYDPFLRESDGSQEGNAGYIGKVREIIDKSLRLSIAIRGQDVDIHILPVKEGEQSFDEETMVELKGKNEGKIKFCICPPFVGGDGEHGFVEKGKVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PF40</accession>
    <name>A0A8H7PF40_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="1">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_000131</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT/DHAPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF45">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG8306-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="814"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2172784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1497" mass="168381" checksum="968D554B0984C914" modified="2022-01-19" version="1" fragment="single">MSSPEDSALPSSEPTSQEVTLVDDEQPETVSHQSDVLPETASQDEQVQSEEPREDTTTIQPESEPDRIVEKESSDYEPDHEASAAEEEVNTSETVTDSLQISNINNLGIHKPEGLAKQSALEFYRGKSILITGSTGFLGKTILWKLIDALQTDLDKIYLLIRYGNSKRKIGRPHERLQSEILSDPAFTSLRRKIGHKRFDAIVASKIIPVACDLISPELSISPEDRDGIIKNVNVVIHCAASMDHDERLDLSLETNTLGTLRLIDLVDECEKMQAFIHISSAYVNSNLPDGEVQEFVYPTELEDPEMLLKEIVSLELQDIPKMTQRILAIYPNTHLFTKALTEQLILKRAEMNRVDEAQGGKTQWPIAIIRPTQLGASVNEPLAGWADGLTGANATFLLSGRGFQILQPNQGDSVADIVPVDYVARVVLGAAAMIQYPGVEFALPYAGQQRLPETTSTFPYIYQISASVLNPVTWREIYDGIREYWMRTSNVAIPKSEDYFVSNKAMFKARFFMKYQLSNSISSVANAVVTGDNKNLNSVTKMTNFASQVVAANQPFLKRSWSFDCRNLWNIQRYLIGDAAFNIESFRDLDWSTYVEHYNHGVHLYVAQESQGLRTISCAPGWDCATHTKMLGFQNLAIDKQVESILFSTTDIEKRSQRMLSQVLQSLENTDRHRDRRLQEEWVADFDTSLDDWCHDDSEVLTNGQAINERGQELGRWRAQIGDNDDVVKIDVLNDRRVGACIKQITESSGVPQQTVVGEAIKLFQRMKERTQLAYVWFAGHFLHLLLQKLFESVQIREQDISKLKRAIAGRTVVYVPTSKSLMDNLIVWYITLRYKLPVPAIACDEALGLLGPISDVLRIMGTFFVKRNPESRSPLNNAVTAAYTQVMLREHGALSIMIEKARSRSGQAQKAYDDGLVGMVLEAALERNQDQSYPCPNPESPQSPTLKKVVGQDVVFVPINIVYESAPELSVLIDQVLDQKPHSTSNNLSVPLLLPKPSASLAGRHKETEQPRNGKYGRVFVNVGECVSVQEVADDAKTQKSPSYDTSKGLSSLSERIVKAIQKGQRESACVSPVSLVAAILLSGRANNGIQLGIVKDRLEWLCSELRKKDVYVDWHDGEDIDSVIFYSLRLLDGHKNITIDDKHISDKSTIRVVDHADNVLALSYSANQLLNYLFPDAMMSIVYLSFSTATVTRQQLSDRFKLLSSLFRLQFDFTWDDDQMFDQLVSLFQNKDILKKSADKEDTFDRLITSETDAVEHDKICLLASLLYPTLDSYWITLCSLSALEDLPYIPRKLVPILTQWIATHLLSGRRTFYREVLSTEISDYAVHAFLALDCLNQVHGKEKLTPDAQILLLELGINTNEDLLTAATVPKPKVDTTEEIENLPVSESQQEKLKSEKDEIDDMTASVGRLFKISQLCNDIELLRYDAASHTESYHQNAQVFLKCRRQIKSILRADESYASQHGVPLSKEEDDMIQLVYALKMSSPKQTRRISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFA1</accession>
    <name>A0A8H7PFA1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFA1"/>
    <dbReference type="OrthoDB" id="102559at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF38">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="24"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="157" mass="17758" checksum="7DF7803D99EE49F1" modified="2022-01-19" version="1">MSYAAPLVKDTELLKLIKDKTKVPKKDYVVIDVRDHDFTGGNIPGAVNIPSRVFVDNVHKTIEDYKDVPQVYFHCALSQSRADNISKLGLFMITGPKAARIYNESKNLHGIKSDQKVAVLQGGFEQWYIKHRKDSSLIENHDPEALKGLLFEYGVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFL0</accession>
    <name>A0A8H7PFL0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1168-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFL0"/>
    <dbReference type="OrthoDB" id="10067079at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009548">
        <property type="entry name" value="Prkrip1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507:SF0">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06658">
        <property type="entry name" value="DUF1168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="21413" checksum="17AD3D89C0AE1CF7" modified="2022-01-19" version="1">MADKADKPKEERKSWHTLSYQEQQQRQLQKLFERVDKPVAIPEPTKERVAKPPPDVVRNVQGSSAGAGSGEFHVYRALRRKEYTRLKDMDEQELKEKEARDYEEKLARMRAEDEERTAKNRAKRRRKNKDSKEKEKGEKVAKTSEDTPKKKSDTKSDKKIEGEKKESNEKSNADNDSSEIPITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGA9</accession>
    <name>A0A8H7PGA9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGA9"/>
    <dbReference type="OrthoDB" id="2356153at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2173358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="206" mass="23277" checksum="C429848BA4325B42" modified="2022-01-19" version="1">MFSPLYHIPALDKTGSSKVDNSSYYPLTPVDDCVSELNFIPESAPFSLEEDAEMANDDYEQHDFLQQEHSLVSDNDMVYFAIHRPARFTASDESVIRSIEPNTPCYAINSSGDFDNNTIDNVSSSSTSSSRSVLHFKGSELTKMIEEYPNAIFYALFDPTWAEQDQIDDFFQQYPDAVVYSVPRPRHLVPPTAEPIHPMNTDQSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGF4</accession>
    <name>A0A8H7PGF4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGF4"/>
    <dbReference type="OrthoDB" id="5591789at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019365">
        <property type="entry name" value="TVP18/Ca-channel_flower"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10233">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01077">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="171" mass="18417" checksum="02659E188CCF72F2" modified="2022-01-19" version="1">MSLPPETSRCTVNAATSYLCTISGLVILGVFSLGSNPVFAILGWVFAFILVFVEVPLCMKVYNGHCSVCCMILERNTYKFDVSYITISSVLPVLDCDDAFATRFENSYLRTLLYFVMAIVMFLSATISKTLLLLPACLLLFAAISYGIAAIKGQPHASSSALGGTGVDNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHC9</accession>
    <name>A0A8H7PHC9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_005047</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHC9"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2173629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="347" mass="38316" checksum="BADA2AB1486F2196" modified="2022-01-19" version="1" fragment="single">MVTSLKPGSRILVTGTTGYIGAHVADQFLQAGYHVIGTSRSAAKAENIRKYFEKYGKGKFEIYEASDLQEEGVFDDAVKDVDAVAHVASPVVFIAEDPYRDVINPAVEGTLNLLNSVHKYGKNVKHVVVTSSVASVVEPKPEGHVYTEADWNDSVVKAVKEAYENKQDLPGGAAYCASKVEAERAVWKFREEKKPAFTITTILPSYVYGPIIPPPKTPQEVVAASTPKFVIEYYLGTKSYEDPLPSSGYINVIDVARAHVLAIEKADKADGERYIVTAYTCSSQRTVDILRRVYPERQNVIAEGHPGQYSEVKAVNGEKIVQELGLKYIEYEETVVQTIESVKQAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHY7</accession>
    <name>A0A8H7PHY7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_004326</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHY7"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000116">
        <property type="entry name" value="probable protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="7">
        <location>
            <begin position="58"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="8">
        <location>
            <begin position="160"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2174303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="38487" checksum="9A16D70446D80B25" modified="2022-01-19" version="1">MATEEEKLTSKDYYFDSYAHFGTYLFCIHEEMLKDEVRTLSYRASIYQNKHLFKDKIVLDVGCGTGILSMFAAKSGAKHVYGIDMSNIIIQARQIVEDNGLSDNVTLIQGKMEEVQLPVPHVDIIISEWMGYFLLYESMLDTVLVARDKYLAPGGMIFPDKATMYIAAIEDGDYKDEKIGYWDNVYGFDYSSIKNLAIKEPLVDTVDVKTVVTSPYPFKEIDILTVQKEDLAFTSDFKLTAARDDYVHAFIAWFDIAFTACHKPVRFSTGPHAKYTHWKQTVFYTPETITIKAGEEISGTLRCAPNKSNPRDLDIDIDYRFHGINGECEEHCDFKMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PI83</accession>
    <name>A0A8H7PI83_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NOT2/NOT3/NOT5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_004351</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PI83"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="209"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="7"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2174328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="332" mass="36215" checksum="E44E65219AB9F0EE" modified="2022-01-19" version="1">MLALTHMLSSASLSTSPSSNHSPPSTAFADSRGPPFVNSSRHTISSRYSPIRDGFDAAKRKTSPRMNTLVRANNLHTPIALPSPGSTPKLSDTPSLNLRSPPLARQEGIDIVQWLSATTLSEQSDLPSVGDSGFLTQGSTGLDNGYSPQIARSSASVYSSHDTGPYGLHGLLAITSNYATDDLLMMTLGHDPANLGLDLDSPDLLSERLCSPWDEQEHPDVLVARMPADYRAITSPSPNLLSGQLGNLSNETLFYMFYSLPGDMIQNVAAMELYQRNWRYHIDLGSWITMQDGSSPPSSIATYITCIYFDYEAWAYGTKTMTLEKNALEQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIZ3</accession>
    <name>A0A8H7PIZ3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ribosomal RNA assembly protein KRR1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_006006</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KRR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIZ3"/>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="14">
        <location>
            <begin position="125"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="277"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2174944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="321" mass="37198" checksum="EC6DB5E19A13DDAA" modified="2022-01-19" version="1" fragment="single">FALNSQSPDLKKLLAWDTDDIDHWKIDEFKAEYNSHSFTEESSFATLFPKYRENYLKEVWPHVTRALDKVGITCVLDLVEGSMTVKTTKKTFDPYVILKGRDLIKLLARSVPFPQAVKILDDGVACDIIKIGNIIRNKERFVKRRQRLLGPNGSTLKAIELLTKCYMMVQGNTVSAMGPYKGLKEIRRIIIDCMKNVHPIYHIKELMIKRELAKDPKLAEESWERFLPHFKKKNVKLNKKPKSDAKKKEYTPFPPAPVLSKVDMELESGEYFLKASEKKARDMAERKQKQTETTLKRKAEREKDFIAPKEHVQKKSKKASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJ38</accession>
    <name>A0A8H7PJ38_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_005989</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJ38"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="365"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="173"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="269"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="319"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2174927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="409" mass="45923" checksum="56C8525355549CF8" modified="2022-01-19" version="1">MMSSNVSISDFEEHQFLVNSLQHTIHNSRPNTHVDTINNGYAACQQQTMQTNLAVMQGQGQDGMFEPSYGFATLSPRSSRMATGTTCLTDFGYLAADNTDHKQYNWLYDSMDAYMPTMANVENDLFVNSLLQQQDSVFTNEAIETAIGGMSYNSKMMTPESASANSQYSSIFSAQDHSENSTSPRRDRSFSSSETSNNSDVDSEMEEMHTTRQPNMFTAWRNPPTQDQKIFIKIKKSHSSGSMTTKSLGQRKLSRKSFTNLYVTSVNQAKNLSGKRNDKLRRKYESPPNSARSTSSLSSLTYASNALKISDSIGRDLSCHAASEEEEEDTPYVDDEDDEDDDDYRHTAATSTQTHSKKGRNVDKACNHCKRSHLRCDDMRPCKRCVSTGKNGCKDVEHKPRGRPKIHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJ87</accession>
    <name>A0A8H7PJ87_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJ87"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="270"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="413"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2174301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="492" mass="56737" checksum="5277955BE7558B3E" modified="2022-01-19" version="1" fragment="single">MSASDVSNTHSVPMVVLKAQLTCLVAKYDDRKQGTILTRDLLALIDQYEKENQVTLLTQEQTTAIEPFTLSNPDLDMSPEDIINLVKLVSPDNQDTPHTTNIPSPSIRPRTSAPLRHVKPPIHKHTTSRSTSVDESLNIDTKPWNYFASSIPSPTDDTMSLSALSSSDLEQEMMDDAAVEQMSLYYQKTLQLTKRLKESERSLANMAYENESRITHLQSFVDEMNANINNQKKEIIEYKGKEKNSLEQIIALEAHIAQIQSSESDHKQVYTSLRQLIAEKSEETQKLQNALRSKEVLLEKTEETFSNMNKEFRQLMLERDRLVEMQYQLEQELVMSQSAHMKLEEQRCENERLKQVIDDLSYDLDEARNNRHRRTFSKPDVTENINDLQTELTRHYNTQPTPFAGDNDEFLEFLKEQQEQQDATERLRTMENEKDYYKAQANDAMQDLDKAKSELDDLRKALQRENKYLVTELADLQSKAPSIPPPPFSESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJA3</accession>
    <name>A0A8H7PJA3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_005837</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>glycerol + ATP = sn-glycerol 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJA3"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000177">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000108">
        <property type="entry name" value="Glycerol kinase, glycosomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="14">
        <location>
            <begin position="13"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="15">
        <location>
            <begin position="272"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="517"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2174775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="531" mass="58550" checksum="8313BF85959DA99B" modified="2022-01-19" version="1">MLSQRKNCDKVFIGSIDQGTTSTRFLIFDNDGVLVTSHQLEFDQIYPQPGWIEHDPIDLIKSVNKCMIEAVRKFEMMGYEASAIKTIGVTNQRETVLVWDKNTGKALYNALVWCDTRTAPTVKKLRTKEGSHKVAHMCGLPLATYFAGVKLRWLIENVSEVRDAIKEERAMFGTVDSWILYNLTGGKDGGVHVTDISNASRTMFVNLETQAWDDWLLEFFEVPRHVLPKIVSSSEHYGDMASGPLQGVPIQGCLGDQQAAMVGQKCFSQGQAKCTYGTGAFLLFNTGESHVTSKNGLLSTILYKLGPDAPVIYALEGSVAVAGSAVKWLQNNIGLIKSEKDIGKLAAQVDDTGGVYFVTALSGLFAPYWRDDARGTIVGLTNFTNKRHIARATLEAVCFSTRAIIDAMRNDALVPLQILKVDGGLSNADTAMQIQSDVLGIEVERPAMRETTALGAAFAAGLAAGIWKSTDELTKLTVNAHDTFEPKIDEKKRNKKYKEWEAAVERSYDWTRVVGNDDSESDEDEDDEKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJI4</accession>
    <name>A0A8H7PJI4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ArfGap-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_005957</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJI4"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF160">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="271"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="9">
        <location>
            <begin position="417"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="611"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="694"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="716"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2174895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="743" mass="83646" checksum="C99A566FA9A28BAF" modified="2022-01-19" version="1">MPALDLKGCVEDSPVFRRRIAAHEESISNFDSSLKSLAKLVRSQVDLSAAVEFATIAQSQDDPIVGHALEKFGKSLTEVEKCRNLMNTHITTMFLEPLDQFIRNELSPVKELKKKFEKSSDETDTSLAKLMSKKPKDLTILEAARDLAENRRRFQTDYMEYVMKLNEVEAKKKFDFVENILGYMYNSSVFHHQGYEILKDLEPYMRDLTGLLQDSRQRYSEELVESQSFQLQCVKTLIENSHISPDIRPASPSMGSARSSSSDMIPKAQGPVSKAGYLFERKSGRMLQSWVRRYFSIDGEDLIVTTRNAKLGRDEDQPTSINLRVCSIRIADNYDRRFTFEIISPSRVIALQAENEADMLDWVNSLKMVNQLALNSDKVLASSFRIFGGGKKPHAAENHTGKKPPVPFTEISTESDKELIKRVRSLPGNNFCADCSAADPDWASINLGTLLCIECSGIHRSLGVHVSKVRSVTLDKWESESIEIMLLLGNVKTNEIFEAKINNEKQQKPLQPSSTRAEKDQFITDKYVRRKYVLDSDEAERENVNKEFWAAIKDSNLHTALRCLALGADINYRNPDDNLRTALHIAVLQEDVVAVEFLLQWFCDVDQGDADGWTSLHHAASENNVRFVLTLLRRHGKPDVQNNEGKTPLGIAVDKQHVQAVTALRLFAFDKQHNSSPASSSDFGFREAMSSFKSPRLEHRNSTASHSAVDLRPGAASNSDSSAVEKTSILNDDQNSTLLRTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKD3</accession>
    <name>A0A8H7PKD3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_001115</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKD3"/>
    <dbReference type="OrthoDB" id="1937997at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="234"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2175468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="459" mass="51773" checksum="8B299F12E59EE566" modified="2022-01-19" version="1">MPPKENWEKYDKHVDDEKEDEKIVGTWYILLRVTMRSIVLPGVITLTLALDEGDIQLLKTYGQGPYASELKKIEQDIKDTQKRVNEKIGVKESDTGLAAPNLWDIPADKQRMQEEQPLQVARCTKIIQSTDDEVSKYVINVKQIAKFVVELGERVAPTDIEEGMRVGVDRTKYQIQIPLPPKIDPSVTMMQVEEKPDVTYKDVGGCKEQIEKLREVVELPLLSPERFVNLGIDPPKGVLLYGPPGTGKTLCARAVANRTDATFIRVIGSELVQKYVGEGARMVRELFEMARTKKACIIFFDEVDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALLRPGRLDRKVEFSLPDLKGRAHILKIHCKSMNVERDIRYELLARLCPNTTGAELRSVCTEAGMFAIRARRKLATEKDFLEAVNKVVKGYQKFSSTPKYLIWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKN4</accession>
    <name>A0A8H7PKN4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_001323</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKN4"/>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="178"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2175676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="268" mass="29771" checksum="9B522A6632E44511" modified="2022-01-19" version="1">MAHLPHRPSLADIRDLEHHFCRDFTCCGQTLGDLHDLLEHYEECHVRLEEDERTSLENDEALPNMDDTIVSENLEVARPATPLLGLKRANEERSDQLQPIAPSAISNIDTGHGHKRQRSVPPDMSPLSIDTLNVPTSFSATATPTSLGEDFLAKAGLDVASSTLASIATQDVNANKPFKCTVPGCEKAYKNPNGLKYHNLHGHHGNDESDTERRLQRPFECTIGSCRKRYKNLNGLKYHVEHSHLVVITNQLNNMLPHTPELSPASTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKS2</accession>
    <name>A0A8H7PKS2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 164</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2175021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKS2"/>
    <dbReference type="OrthoDB" id="17328at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026508">
        <property type="entry name" value="TMEM164"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20948">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20948:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14808">
        <property type="entry name" value="TMEM164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32687" checksum="7EF9E1AACD73DF2F" modified="2022-01-19" version="1">MNLLSSGYTTLGKWVTSFAPKVPTETDWSQSVIGSWYIPPSQHGLELIILSTLFIAGTAYFGYKALGPGLNRKLLFNFVPSRNHSLLERTLFTALALSLATTVVHKLIRRTMLFMLQPCHMSAMLLLVVMAWPRKSSPIPNVLFNIYLHTLWGTIAALLFPDLRDHFLPGETINFFAEHILILILPFYMIYTGRYLVLPASVKMALFSFALYGLFHCPVIHVVALKSTVNINYIFTPPPIGFLIKMGSLYRPFLYCLAMANMFVTRYVLIGTSLFIIPAKPTYLQKKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLJ5</accession>
    <name>A0A8H7PLJ5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_001088</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLJ5"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="253"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2175441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="510" mass="57321" checksum="3F2DD36C4A527AB5" modified="2022-01-19" version="1">MESSDIEHCTRTQDRSSPAKTNGTETNSHLSEDHIVNNINHARGRPASCIFVASLSKLLKDSELCHSVAQHFAQWGTVLNVKVFRDWMQRPYGFVQFEVGGPHNSIICLDSSIYGEIAHFTEHMRRSKSIERSLRTIYLGGMSNHTKKKVPFSSQLPNTLAAPHIDLVLPAKDIQSFAENFGGVENITLIKLSLKQPPAVDAFIRFHYRDDAVKAYLAIAADPPFQAVVVEWAANVNYSNDDPCDVPEQYFSSIVYVKNLPFHAKQEAIYNRFGRYGTIVSVAIIGRKPFAVRKKLGNTTQCCAYVHYKTQEEAVCAQEGENGSSMQGRTLQVTLAHDSNLSSGNGNNKTQHPSHTNDRKHQSKILYAAAKYSKPQEDYKANGMPIQSLNKNYLEKRHQDKYVTESGATLPLYPYTNGYQGSTRLRVCKFMKIQLTKSNHVAANNLMQYPPTHANPVDYSGMCYSMPPMYPYCLDYGNGYYYNTGYGYNGTFYSAVMPYPAATVASRHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLN2</accession>
    <name>A0A8H7PLN2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLN2"/>
    <dbReference type="OrthoDB" id="2372567at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="289" mass="32834" checksum="E22B5AB2A4C0AE3D" modified="2022-01-19" version="1">MSTTSIHTDSVKLEPPNVNLIFKVPESLIAPTSMLNPYQSPLTEENLQTHTLECPSSRETKAQLILCYVTMQQNILEAEAQLRENAQIQAQEMVLVEFPRDSELIRETMCEMNKTRLSLAHSIRNNASASSLGASRRRTTLLSNVLEAQEEEEEVWNEKNRIRRNKLLNIFEKLSEPLKMLANSKSSKAGFVLSRTTASQHRRRGQQFGVNEDYDSGISVTSPKSKRNSIGGFSYQKDKTHSKLGTSYRDSIDEFAAYRYPKMIPARLSTDQSLRRHSTTDISYLATAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PME9</accession>
    <name>A0A8H7PME9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">INT43_005604</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="5"/>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PME9"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1150:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11610:FF:000009">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12470:FF:000003">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="18">
        <location>
            <begin position="653"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="978"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG2176370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1035" mass="116638" checksum="AE2EC9792C1EB0AC" modified="2022-01-19" version="1">MYRFSRAVKPLASSGSRALHLSRALPLRQPRNIASFHSMSTRLAAAKTAPEPNDIFLQGNSAAYIEEMYEAWLKDPSSVHLSWQIYFKNMANGVSPGQAYTPPPTIVPSASARLPSLPGAQLASGSSSEVVDHMKIQLLVRAYQVRGHHIANLDPLGIQHVDLQSSTPKELELSYYGFTEKDMDRKFTLGPGILPGFMDGARDMTLKEIVDNLKKIYCGSIGIEYIHIPDRAQCDWIRQRVENPEPFKYSKEEKEMILDRLVWSDSFERFVSTKYPSEKRFGLEGGETLIPGMKAMIDRSVDLGVESIVIGMPHRGRLNVLSNVVRKPNESIFCEFSGSIEPSAEGSGDVKYHLGMNYVRPTPSGKRVHLSLVANPSHLEAVDPVVLGKTRALQFYSRDDDRSHSMAILMHGDAAFAGQGVVYETMGFHDLPAYTTGGTIHIVVNNQIGFTTDPRFARSTPYCTDIAKSINAPVFHVNGDDTEAVTFVMKLAADWRQTFKRDVVIDLVCYRKHGHNETDQPSFTQPRMYEKIAKQKPVLEKYTEQLKNEGSVSIEEIEANKKRVWEILEESYTKSKDYKPTSREWLSSSWPGFKSPKELAEEILPHYPTGVSTETLQQVGKAISTIPHDFNIHRNLNRIIQQRAKNLNEGKDIDWSTAESLAWGSLLLEGKHVRLSGQDVERGTFSQRHAILHDQKNETPYTLLDNISPEQAAFTISNSSLSEYGVLGFELGYSLVDPNALVMWEAQFGDFANTAQCIIDQFIAAGEKKWLQRTGLVMLLPHGYDGQGPEHSSSRVERYLQMCDDHPYVYPSPEKLNRMHQDCNMQVIYASTPANYFHALRRQIHREFRKPLIMPVSKSMLRHPLARSSLEDMTGNTSFQLYIPDAHPEHLEAPEKITKHILCTGQVYYALLRAREQNKLTNVAISRVEQLNPFPYEQVKEHSDKYPNAEVIWCQEEPLNMGAWSHVQPRITTALSQTEHHSGKSPIYAGREPSASVATGNKKQHLHEEYSLLSRALLGSAEKPKEVQSGVPVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMI5</accession>
    <name>A0A8H7PMI5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMI5"/>
    <dbReference type="OrthoDB" id="2395524at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="517" mass="59631" checksum="3B43AC7DB4C2B663" modified="2022-01-19" version="1">MERMTNHEYDLQYRRHMDKLQRQAQYISDLMRYASIQDDAQAPHNQYHRKHSSVPPPPRQRSYYPEQVEKSGPYIPAKPQQKPLKSILRRTEPSKVAEMPLRSPTPPPLRQRPVSANQLSNSPIQDNVRAGGQRRVRIQGPHHTSRYSRDVLPEDEDDYSVEDQYYDRRYRTNNHHRYESASEEEYDEDQAYSDDDDESFEPPQPFEQRHIYQRQPVPQQMYSSPGNYTSRKHIQNNQMHMPAGDPNKYYQNTNSMDSYLDSTIHQMGLHNAYTDSYQVSSSMPSQNPSVTSILESFFETPAAPIHPNSSMSSPLSSQDDSSRNLSSPRPSFSPSTSFNNSTSPKGFLSRFRKSPAPAVNPPNIVTTRPMAHRPNAKRHELLSDRDVAEIREQTRTQQYEATLDPAVAAKDAVVKVAALSKVWCFRIHSQQPEDQSDPPVWTAFDYKHQGKLSKYATNNKEYMFRDSHLQGDVLILPAKGSGHVRGKTQARLEVRQLEIDPDTTFVYREGVKAKKWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PN35</accession>
    <name>A0A8H7PN35_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_005689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MT-A70-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PN35"/>
    <dbReference type="OrthoDB" id="61116at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF4">
        <property type="entry name" value="N(6)-ADENINE-SPECIFIC METHYLTRANSFERASE METTL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2176449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="382" mass="43673" checksum="E0712E0E52654056" modified="2022-01-19" version="1">MSIIARTDNAVLLDPKPAFGDGLHNHQGSWKLRLGEYNLDQPYFWPKRDMPPRAKRRKTEPSKTETQTEENFLQLEEYFNQCLKELVDIWPAIKDSISEAEPPPPLSDSVESSNMIDFVQNAELVKVVKSLTFQLDPEQSQKTMILKDTNSIELPEIYNTIISNSMSQYVTLAVEPGLQRYLIPAGSTFLLGQLDDSMKTLTSHAHRSSQYTTLDIYALFEIPLPKLMATECIVAVWVTNRPKYKRFLIDKLFPAWDLELLGEWYWLKMTTAGDPVMPLNSTHRKPYELLLVAKRKSGSGPPIPQKQLFASLPSRSHSRKPPLNDLFAQYLPTNPRCLELFARCLTANNTSWGNECLLFQHESFFTHVKNDTTEATQSNFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PN66</accession>
    <name>A0A8H7PN66_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyanate lyase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_007734</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MBF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PN66"/>
    <dbReference type="OrthoDB" id="10019422at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008824">
        <property type="term" value="F:cyanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00559">
        <property type="entry name" value="Cyanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1160.10">
        <property type="entry name" value="Cyanate lyase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00535">
        <property type="entry name" value="Cyanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008076">
        <property type="entry name" value="Cyanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003712">
        <property type="entry name" value="Cyanate_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036581">
        <property type="entry name" value="Cyanate_lyase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00673">
        <property type="entry name" value="cynS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002773">
        <property type="entry name" value="PRK02866.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186:SF2">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02560">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001263">
        <property type="entry name" value="Cyanate_hydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01693">
        <property type="entry name" value="CYANASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01116">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55234">
        <property type="entry name" value="Cyanase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanate lyase C-terminal" evidence="5">
        <location>
            <begin position="80"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2177078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="152" mass="17392" checksum="1F63902E3BB54632" modified="2022-01-19" version="1" fragment="single">ANSKLTPLSKRLFEAKRQKKLTFEQIGQKMGRDEVWVAAVFYGQAKPTQEDGEKLSQILNVPQAHINEDMGPDFYPDRGGLISIPPTDPTLYRFYEILQVYGYPMKAVIHEKFGDGIMSAIDYSCHIEKEEDPKGDRVKITMSGKFLPYKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PP43</accession>
    <name>A0A8H7PP43_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3'-5' exonuclease</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Werner Syndrome-like exonuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_007897</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PP43"/>
    <dbReference type="OrthoDB" id="1920326at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF109">
        <property type="entry name" value="3'-5' EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="10">
        <location>
            <begin position="88"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2177240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="214" mass="24203" checksum="D688662E682C1820" modified="2022-01-19" version="1" fragment="single">YPVGMTVTINGRQGKPIRSLPACFRSASTIAKDDGKPSSSYTKILSTEARQRQLLYKATIDQLPYIRDQLPHQKNDKQEPQSHQFNLFYFCREGNVFGLDLEWRPTFVKGSKENKTALIQLCNAKTVLIIQISRMHVFPQELKGMLQDRNIIKTGVSIRGDALKLYRDFRILTNGLVDLGALARSTKAKELEDHAGLSLRLLCGIYVSLHTIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PP45</accession>
    <name>A0A8H7PP45_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_007643</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PP45"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF50">
        <property type="entry name" value="BIFUNCTIONAL ALBAFLAVENONE MONOOXYGENASE_TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2176989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1089" mass="123993" checksum="5477461719697B1D" modified="2022-01-19" version="1">MSSTISASHLDSIKTTLLDQALYYRNVFMDKVFPRLTKQSRATYIAAAIGIFVVSKLYSTFAYPKNLRHIKHAPLLPYMASLIRKDTTIGRVKEFLIPEWKDSNGFMVLYEQFGWTINVTNPEAVKTILYKTDIFPKNDNNEKMPAGTLIRKFFGKTNLALANGHEWMKRRKIANPVFHRSMPVKTFTHLTEKMMKQIDNTKGEVSIQLLLQRFTLDAIGLVGFGFDFNAIDTPDGEWVTTYNDITDNIADFQFLFFPTFDTTLLNLFPARQKYHEKVEKMNKLFNSIIEHKKEALSQAKSDVDESEKDLLTLMIEAGHNEDDKLEPLSSSELRDELVVFFLAGHDTTSNTLTSALYFLAANPDIQRKARKEILDILGDDHSNVCPTLEQLKEFKYLTNVMKEAVRLASPAQNLVERTASRDTEVAGTFIPKGSLVKVNILGLHYNPNLWNEPTKFNPDRFIEGGELESRSSVYSYLPFGGGSRQCIGMNFSLAEQRIALSLILRRYELSVPEDSIHKDELKFSSNLFLNTALDGQAPSVSVLENIMSSTLSASHLDNIRSTLVDQTLHYRNVLMDRVLPRITKQSKTTYIAAAIGVLVVAKFYSIFAYPKKFRHLKHAPLLPYLASFLKKDTYLDRVQKFIVPGWKENNGFLVVYDPFGWTINVTNPDAVKTILYKTDIFPKSETNKRIPAGSLIRKFFGETNLALANGHDWMKRRKIANPVFHRSMPVKTFTNLTEKMIKEIDNTQGEVPIQPLLQRFTLDAIGLVGFGFDFNAIDNPDGEWVTTYNEIAANISDFQFLFFPTFDTTLLNLFPARQKQHENVAKMDKLFYSIIEHKRKAINQADSNVQENEKDLLTMMIEAGQNEKDKAEPLSDSELRDELVLFFLAGHDTTSNTLTSALYYLAANPDIQHKARDEVLQILGDDHSDISPTLDQIKDFKYLGNVMKEAVRLASPAQSIVERKVTKDTELAGTFIPKDSLVKINILGLHYNPNLWNEPTKFNPDRFIEGGELESRSSVYSYLPFGGGSRQCIGMQFSLAEQRIALSLILRRYELSVPEDSIHKDELKFSSNLFLNTALEVGLNFKRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQ01</accession>
    <name>A0A8H7PQ01_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQ01"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034825430" evidence="2">
        <location>
            <begin position="26"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="381" mass="42390" checksum="0DD90FE1EA8F27CB" modified="2022-01-19" version="1">MMLQKPTQVIHLLILLVCLITCVEGTAMSLEVLPTTIKLDFIGVLAVTVSAISVESMLEGFMSHRGRWRCAMTGPGYLQPGLAIAVDVFKHIFTLQVCDAVNFPFRLIEKVDTKSYLLPNQKPQPLESGYLATVLARHNSSISSNWSDQRTQAMICLLRRDGVILEPGRDGSVWSNYFLWLVSMTATAAPLAVAVWQEDWWMLAFGALLVLDAILRTAYAMKADMSYKIDFDHGNQNNSGSQEEGSNNMRTTVARYGNTMCLISGSTDVVKPACRSRIVGKVVPRFLTVIYAISSILQLFANLIAVPNGGAYSQLAYLGTICVCFFMQTFCHRLRTRVGPDQHRVICSVLGTKVEAVAYMAYLIRVGKLRYIPRSRAAKWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQ29</accession>
    <name>A0A8H7PQ29_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQ29"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347:SF1">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="6">
        <location>
            <begin position="39"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2178197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="272" mass="30459" checksum="245B6D60D7E2BC3F" modified="2022-01-19" version="1">MTNMSSSFPLIHDDLATRDTSPPPYYPSSPAMEAHSNSNLFQEDKVCRICLSSNDDIGADRYAPRNVNPLIQPCLCKGSMAYVHIRCLQRWRAEQGKQAFQCEICHYSYNISRPFWAKIIGSPILAGFLTLVIIFGLLLAIAYIVKVIDVYGFHHIPIPEDPNWQEWHGNSQFIWLDRFYLLISLLIMGCLGFIAIGFMSCSSVVCGWDISPPSMNMAYCEMGACGECGVFIFVVIAVIGFFAACLGTFVLVYTLLSKSLTHAKERVLEVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQQ6</accession>
    <name>A0A8H7PQQ6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQQ6"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000130">
        <property type="entry name" value="Related to PTC7-type 2C protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF84">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="180"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="498" mass="56185" checksum="629E8A5A8C2DE175" modified="2022-01-19" version="1">MSSRSRQLPAWMAQKFWNSILFVRYRQYTGKGSATSQRRSYVSWTNHLQSSLHSRAFTHSIRPSAILHTGRFNYPAVPIVPAQHLHNSSVNSLLSESTSTQNSQRPTRVLNILHQRPVIDNSRRWFHATRQRSNSHGEQATPDLQLSVIDYLGDKSLKKPKPTYIFTHAATGFPKAGKRTVLPPQDEDYASTQVGEDAYFRRYDSLGVADGVGGWTGTSGANPALYARKLMHYAYLELERFDNIDDPSFYDYDKADPVDILQKSYEHCLEDAKNEDIVGSSTACLVILRDDELRIANIGDCGVSIIRHNNYVFRTEEQQHSFNFPVQLGTGSPDTPSDAQRFTVTVEKGDIVILASDGLFDNLFDEDILDIVRHHVAAHTVQSAKVSGPRTVNIEPQTISDALAKRAKLVSEDSRNMNSPFQTRAIQEGLYYQGGKTDDISVLVAIVKDSEDSPDRRFYLIPMSKFRVAIYRLNYYSPPVKLSDADIQDVKLRSGYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PR38</accession>
    <name>A0A8H7PR38_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycosyltransferase family 49 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_001613</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PR38"/>
    <dbReference type="OrthoDB" id="411524at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042285">
        <property type="term" value="F:xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051292">
        <property type="entry name" value="Xyl/GlcA_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270:SF25">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-LIKE PROTEIN LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2178767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="49136" checksum="D6435A6DF1EBE3E9" modified="2022-01-19" version="1">MELKPPVKKALKAFVTGYIVISLFYSAYHLFSVYRGSPATPTPTASAKAVINISASLKNGTWGPQRVKWTNPEGVTDDMPEDFMLTKVFSDAMGPCKVIPYYFRATEEAEAEDITLATLVTHNRLDVLSRLATRYQGPISAAIHINDDEQRDIVLNDLHAMYEGNPHVQRHVDVHLIVDRFDRQFNMWRNVAKFFARTEYLMMLDVDFHLCTDFRKSIRSNSLIMEKLRTGTAALVVPAFEFIEQKDGLDWKTFPTDKKQLMDLVRAEKIDMFHRSWQRGHGSTDYNKWYESDGEYVVTEYNYSYEPYIIYKKEGSPWCDERFIGYGANKAACLYEIYLSGIDYWILPNDFLIHQTHFYLEDTRKKERKYNKKLYDNFREEVCLRYSRMMIANNLWSTPRADNVKAECSKIKGFKSAVGNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRE2</accession>
    <name>A0A8H7PRE2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_001649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRE2"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF4">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="10"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="432"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2178803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="71851" checksum="43AE73AEE3B75F34" modified="2022-01-19" version="1">MIAKQNFAHVTTLIVGAGPAGSFLASNLARLGVQFRIIDKLKVHTTGRAIGLVARTLEILEQVCGSELVDNLVKSGHRIYKQGFWRDGKLTRKSETWECDSLHNYYLINPQLNLEDALRNDIVKLGHQIEYGVKLVEVSTPEDPDEPLLCTLQNETTGELEYVTCKYLIGSDGAHSFVRRSMAVTAAGETPNMVWGIIDAHLKTDFKDIEDANVLYSNEGTAVAFHWGNGITRLAMYLGSPDIANDVVNYRDIRNYLSIDQFIQKMTSVFKNSGYKVEIGEVKWFSIFKIQEKIATEWTAADGRVILLGDACHTHSPGGGLGMQAAIMDAYNLSWKMNLVEKGFANVSILETYTEERRAVAEQFIETSAKIIRVMSNITPSQSSPGLNSSYEKELALLYKRNGQNITVGPAYPFNELNWAGGGSVERNYAFWKSGTTISPGQRAPDVFHMRQYNLRQQEISNETRLFQVTKHPGIFNILIFAKNLDSDIQYHLSDWAAHLSSSNAFFAKYKFEKEQLFAFHTITSAAPDTIDEVNEDVKQFLTNNSTILLEKGLDEDLSNLDDNYYGFRDVTAAEQREQTAHVKYGIPSDETGVILALRPDGYVGAVVCLEDWVHLDEYFDTILGNHNFNSNAEVYDQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRH7</accession>
    <name>A0A8H7PRH7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_001709</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the methyltransferase superfamily. METTL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRH7"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF164">
        <property type="entry name" value="HISTONE-ARGININE METHYLTRANSFERASE METTL23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2178863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="265" mass="30093" checksum="35375805A7055ACB" modified="2022-01-19" version="1">MAQHVEKSGQRNFHYEDGRDQVTVVVHEVNRSLLLDVAFGHFIWPSSIVMAEYVWKYRHQFADSTVLEVGAGTSLPSLILAKFYASGNCNLVVTDTQSVLSNIRRNFALNGILDNGPRTCIRELQWGIFGEGGIDELLETAASQCFYEIKWILGSDTFYDPKGADAFADFEKLLVTVAYVIHRYNKNAKFITAYQERSSKRSIQHLLDKWQLSCRLIPKTSFDFDDTRYIEAADEMEDDIDDSEPAIRIHSGELASVFLLEIYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRU8</accession>
    <name>A0A8H7PRU8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0390 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRU8"/>
    <dbReference type="OrthoDB" id="5239630at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019034">
        <property type="entry name" value="UPF0390"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16967">
        <property type="entry name" value="LEYDIG CELL TUMOR 10 KDA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16967:SF1">
        <property type="entry name" value="LEYDIG CELL TUMOR 10 KDA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09495">
        <property type="entry name" value="DUF2462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2179127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="98" mass="10487" checksum="2B71E0751EF7B27F" modified="2022-01-19" version="1">MAQGQLKKTKAPANKNVKNLSKPKKGAKVIAPKQKALVKQKQIVKKLSASINRNIERQMAVKAGAVGKLTIMKKLADEGAEASKDKKLNPKKGGKTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PS63</accession>
    <name>A0A8H7PS63_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_001750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PS63"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2178903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="313" mass="35338" checksum="6CFFB5112A43D979" modified="2022-01-19" version="1">MSLGRTFTLYTGAKIPAVGLGTWLSEPDKVRQAVLYSLQNGYRHIDCAYIYQNEHEVGQAFTEAKVPRNEVFVTSKLWNTHHRPEYVRPAVEASLKALQLEYLDLYLVHWPVSFAPKGKPEDTPVTPEKDYLFPQKDGKVDLEEVDPLKTWAAMEELVDAGLVKAIGLSNFNIAKIQHILDNCRIRPAALQVELHPALHQQELLDFCAKENIHVTAYSPLGNNIYGKDRTVDDPAIAEVAKKLGKTPAQVCISWAAQRGTSVIPKSVTPSRITENFQDFILEKEDFDSVSSLGSRNRRYNDPGMEEWNCNIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PT35</accession>
    <name>A0A8H7PT35_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PT35"/>
    <dbReference type="OrthoDB" id="2339353at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2179792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="440" mass="50610" checksum="2F0B24FA566DABA0" modified="2022-01-19" version="1">MFFIREAFVRKPFEKKSLVYVRGMTALLLTAVCFAYFVYLAIQVYEDQPLIKLLAVNLTDSYPSPDIEMCSANSPLRLWYCDIVKMDWSIERRNNCTGLVKKGVYSPTMFCQIYQANGSIEFGLDSFQQQPSSQVRRIDFYWEIDNLTASVSQTIAIPALSLQLYDPKFNPWYTGDIATWIPRQFQAYRDITMGVAKATTMQRYTTDIYFTPQVYKAIRPYDFGSLLGMIAQYVDIPTVSTNWLAWPLHFNSNFSNTAMTGQFSIQLASGTMNIQQEQRQHTILSLLALGGGAFGLVNILYVILFGMNRLTPWGLVHRIPFFFEAKPIPAYARSDYLELVKTRTPSIRSSGFHNVDLEKAPLTDYHRWAEKVQDEHPLPDAPSIEPSSVTADDKSFHATSERPLDLEARVQELERILADYFLDTKHLDRMRRKSYRHSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTC3</accession>
    <name>A0A8H7PTC3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-trimethyl-L-lysine(9) demethylase</fullName>
            <ecNumber evidence="2">1.14.11.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_003714</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:60200"/>
            <dbReference type="Rhea" id="RHEA-COMP:15538"/>
            <dbReference type="Rhea" id="RHEA-COMP:15542"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.66"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the JHDM3 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.66" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTC3"/>
    <dbReference type="OrthoDB" id="9547406at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140684">
        <property type="term" value="F:histone H3K9me2/H3K9me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF7">
        <property type="entry name" value="[HISTONE H3]-TRIMETHYL-L-LYSINE(9) DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="8">
        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="9">
        <location>
            <begin position="283"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="497"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="172"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2179927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="690" mass="78139" checksum="415E1B23B628959D" modified="2022-01-19" version="1">MKNLGHIEPSEYYDQENGGTIPIFRPTMAEFEDFLSYIQAIDAYGRHAGIVKIVPPKEWSSAMPDVNNLLETVRVRNPIVQHIIGSQGIYTQTNVEKRRPYTVQQWYNLCQSDEHRPPTVKVDRPQSLPAIKKRRIHAPEQDNAAENHQKETSGPPSASIRFISMQTRSKSKYGSYGATSKFPRNTISLPQDTHLRSPPPSPPRKPAVMLVHDKPVKTKKELKAEELELAHSDKHDPLSFNYHCEDDEKYTVEYCKELERTYWRNLTFTQPMYGADMQGTLFDDSTKTWNVNHLDNILNRIGVELPGVNTAYLYFGQWKATFAWHVEDMDLYSINYLHFGAPKQWYAIQSDYRKRFETVMQNIFSPAYKTCSEFLRHKTFITSPTVLANNSIPVSRLVQHEGEFVVTFPYGYHSGYNLGFNCAESTNFALDSWVDIGRTAKACTCIKDSVKIDVSIFEPHVIQGPTTPPEEEIEPPAKKRKAKRSPVHGVNGVRSNPSKCLLCPLLGADLPTEDGRRVHRLCADFVPETRVVSGPKGDVVLGIDDVPNARWKLKCVLCGKADGACIQCRKGRCCRAFHTTCAQNAGISLHVESLEDGNFLKEGYCPMHDPKREMEKLAKRAQYVQDMVAKLTPNTHIWARWKGGPYFAGTIQSCASNKQNCRVSFADGYSLAVPWKDILLESPETSISTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTG0</accession>
    <name>A0A8H7PTG0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTG0"/>
    <dbReference type="OrthoDB" id="2289470at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2178936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="148" mass="16822" checksum="6F1790C904C51D3C" modified="2022-01-19" version="1">MPTRKILGLLVHVQYAPTVRQVLEKHDIKSVDFEPTDPAHIADPKHDTLSASDRQQLANSIHANRMMRTLKYMRSEIATAVGRYFVDQKWITLTELAASVPPHKDNPFTGTFPPRTHRPQETDTRKRRALSISSSDSYHSTDAMTTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTI3</accession>
    <name>A0A8H7PTI3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTI3"/>
    <dbReference type="OrthoDB" id="2397387at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="255" mass="28385" checksum="3A0A796592715508" modified="2022-01-19" version="1">MWLNPPKRLIGGAKQWSNIARSDFLCLQVSSRHRQHVAESHDQDIIYQGFMTLSEQLNELEDKVTFKRIAHHAHQLAVQSDKIINRSTSSIALSDEDNSEMGQNDSPLDSNDVSASGSTASLHDAPAAETPVQDDTVDIEPETSYIAPTADSNYGKGTPPETPEDMDIYSNPLEGASWIDPDLKAAFSYFFDGPQLGRNGDANNSKRKRKSDTEKKRDPQSLLDIPFMFISLLTYPDLPQESDNDKAQKIRFAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTQ0</accession>
    <name>A0A8H7PTQ0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTQ0"/>
    <dbReference type="OrthoDB" id="2375101at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="141" mass="15407" checksum="59288BEB2C9C51EC" modified="2022-01-19" version="1">MTSKNDNKQISQFTSLDAMSISTPEEKLAKELEESQLLDQPKYSTHQVFGARCQPPIKVTDVPPPISAPSNSEDGWGDHLPSYTSISMHHRFGYQSVLSSDHLPLIKPNEDGSPRPPPRLFGGYSGQAVVFGAGAQAKNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUX3</accession>
    <name>A0A8H7PUX3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_008586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUX3"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF132">
        <property type="entry name" value="PROTEIN-LYSINE METHYLTRANSFERASE C42C1.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2181004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="59286" checksum="8BEB082AC48DA81A" modified="2022-01-19" version="1">MAKSIAVSLCTDAPLPHYCPNIPKKETHEDYYKDVYLKLSYNQSLFRINLHRSTQKAIRVAQWSRVDLCLVNEVGLPLVDDMGDDVQVQLKCKVLSKGRHNFIDNQLYDIEIRPLQDDAWSSNEQKDQYLVGFYNSSYGGLEYRLQYRHNADIELDASQYHEIYLYIQQAPLENSSHAAKVLPLAIGPMVVNKPVQTTKDVCASSMPMWSAIVAQKPYPVALPCKSVDNGFWDQKQNTNRAYRAYPLISLDKNCYQHYVLMEEKWKLGMPGKIWDGALVATDIFAKRLKRDPSFLDNRHVLDLSAGSGCFGLTLAAAYQHMRQPHPTDRLVKPPLITLTDVQEALPLIRHNYLLNMLPQQVRECRCPTNVPEGYFRDQAIVSIQPLRWGFQCDALKIMTVKPIDYLVASDVLYDSSKSSALAQTLIHLSTPGITTVYLVYKKRALKREDEEAFFKDCQKYFDINIMPTFCDDSDSNLYRDETSLDGATWLTQDVDEPSTKPANMVKTTNVVIYQLKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXF4</accession>
    <name>A0A8H7PXF4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXF4"/>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="58"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2180916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="325" mass="36870" checksum="9D619FFA384DE5E3" modified="2022-01-19" version="1" fragment="single">MSEFAIPEAPKAKPPPQGPVLAYNKPEWSAAAKYKYSFEILKNGTVVENFEGPAREFITVGRLPMCDLELEHPSISRYHAVIQFNDEGKAFLYDLASGYGTKVNKATADPKTYVGLKDGDQIRFGESTRLCIFHTEYPDEKEDEEREGEVVSRKVTLIKRKPVDVPVNDEVTWGLPEDAVDDEPDVDENDLKSIEAAEKRAEERAAAQKERMKRLFGDDEDSDDDSFYDRTGAVEKHKSRKTNKGTAQKVETYDTLLVKQKSTQQRIADIEAELKKEEAEAETSEQPSRDNKEEDELDSYMENLDKATAKPNKSHLQKELKDLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXN0</accession>
    <name>A0A8H7PXN0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_007104</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXN0"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034790839" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2182177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="135" mass="14432" checksum="B94F73AF86D84474" modified="2022-01-19" version="1">MFSLSLSLFLAAVDTTIVATAIPKIGSDFNALEQASWIATAYILSFDALQPMYGKLSDIFGRKNSLLVAVFVFLLGSVMCGVSTNMIMIIAMRALQGAGGAGVFGIVFITTADMIPLYARGSCWEIMKISFAEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXN6</accession>
    <name>A0A8H7PXN6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_006947</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXN6"/>
    <dbReference type="OrthoDB" id="275582at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2182021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="155" mass="18005" checksum="65790CD44DC5F3F8" modified="2022-01-19" version="1">MSTPMRQGLNKVYLPNVIFKMVRSPNLQPNQVAFRVPPKCNKFDIHSYLTNIYEVNVQEVRTMNYATRIKRRKDGRVTGREAAFKKAIVTIDEPFNWPAEPDLNTLGGPDRELAHKAASRKLKGWRFRAQPAEKSQEKELHQEKLAKMQAEQEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYA0</accession>
    <name>A0A8H7PYA0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_008949</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYA0"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="22"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="520"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2181366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="556" mass="60186" checksum="E302823E5A981771" modified="2022-01-19" version="1">MTKTTERRKPMFLKIRGSKVFVLATVGVGLFVDMVVYGIVVPIIPFIILSIDNGQSPEDVDPNANPGDIPQVSRETGILLALFAAGLLGKRVASVRKRLRHSCRVCKCAGDRLQRRQGAMLIGILGLIASTLLFMFSRSYWQLLLARFLQGFSDSCVWILCLCLVADTFPQGEMGLQMGKVMVCYSIGMTSGPPIGGGKNSTINEGINISLYLLLTRFHLALALYHQMGFKAPFVFCIIMAAIDFVMRLLIVERRNNPKEWFDEIDKNDHLTKTEQSVCDSGSPALPDDATATPLTANKVSIIKLMSYGRMWGALLITFIMALVIGSIEPTLTLRLAEEWNYNTSQIGLAFLAQVLPGFASGPLAGWLADRYGAKIVILGSTVVSAVMLALLGVPNRSTGIAPLIVLLVLEGFFGSAVLSPVLSEIAAVVEIENTEDGNTDGFAKSYAVFNIAFAGGMLVGPLLGGFVYSAIGFFWLNIILACALVVCIPPIYFLIGVKGRGLIQRPVAKVESIKEEKPTNALDESLADNDGALEGRQDSLSRVPTVEEVPVSNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYP6</accession>
    <name>A0A8H7PYP6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_007087</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYP6"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="NodB homology" evidence="6">
        <location>
            <begin position="20"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2182160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="225" mass="25370" checksum="915C8848B500ECB2" modified="2022-01-19" version="1" fragment="single">APLTLVKREIPGVQTQCKKGYFALTFDDGPYKYTEELVDILNEKGVKATFFVNGNNNWNIDTDADAQNAIKKAYESGHQIASHTWDHADLDTLSESEIQEEMLRLEAALMNVIGVKPAFMRPPYGNSNETTTKVLNDLNYTVVEWNVDSKDYETHNLSQEMDRIKNELPPSDSGDGAIVLEHDIYEQTVEELAASTIEYVQMQGYNFSTVADCKLLGFDEAPYKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYY1</accession>
    <name>A0A8H7PYY1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYY1"/>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000060">
        <property type="entry name" value="Probable serine/threonine-protein kinase DDB_G0280133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="169"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2182280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="266" mass="30862" checksum="3621390E1AD40145" modified="2022-01-19" version="1">MPRERSRSPYRSSSRSPDRNRRSHSGYRNSGTRSRSRSPRSRSPRSRSPPRRRRDTESYNRDSQERQRRPTSYQDKSNRGEKKKHEWGKPEDVEPEPEEPAKKKEEANFGLSGKLAAETNTFKGVEMKYNEPPEARTPTKKWRLYVFKGKEQVGSNPPDLMHIHRQSAFLFGRDRVVADIPVDHPSCSKQHAVLQFRSVNETNQATGQVRRVVKPFIIDLESTNGTHLNGERIPDTRYIELKLNDVLKFGNSTREYVLMNEDAAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZ41</accession>
    <name>A0A8H7PZ41_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_007016</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZ41"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="645"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="700"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="176"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="189"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2182089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="798" mass="91164" checksum="417DA6420B30E5B1" modified="2022-01-19" version="1">MGKLSSSVKAFWNEHVHFLELHYAYIMFLCFFFSGCYYFDPSGVRSPYIDALFMMVSTSTCTGLNTVTISSMSVYQQSLIFISSIFGSHVFISIVIVFVRKHAFESRFKEIVEYNRKKRQYETMQNRRSTDLENGTGLSGLGRRLSHIPFHRSSDDLHPEIQIIRRPSILEDLSAAKREEEEEEEARQHSQNSSSSNFLPQPNAIMNMTPIQSPRHSIHGTPNASRRSSMVGSLHPLEHDAGSEISESSSTQNENDQVLPAIDNRNSEEQTDANAQTIMFADDVEVQRQRARNRLRKNRTSDRNSNDYVHRDLSSLVEKEQLTQEERFNLGGAEYRALHTLSRIVPLYYLCIPVICSFIFRIYFATSTYGQWVLDTSNGHDTQPVNYWFFSFFSGIAGFNNVGLIPLDDSVVPFQKTPLYLLIMSFLILVGNTAFALLLRLVIWTLWRLTPHHQQLHKDSLRFLLDHPRRCFTTLFPSAQTWWLFLILFIITITELVLFLLLNYWLPVVADIPWGYRVLDGLFQSISTRNAGFSVVNIADVNPSLTIIFIVAMYISVYPVTISMRRTNVYQERSLGIYGGEDGDNVDDNNAFTDTDLTQAPSFVRLRRSNTLSSIMTTTRGLASNIKRPDFFVMQQIQRQLSSDMAWIVTGIFLITVIESAQIMDTSPITVFSIIYECVSAFANVGASLGYPNTSTSQSASYHALSKLIIIALMYRGRHRGKYMRMMRCKYSKKQSKLMIRLFSGLPAAIDRAVLLPSEQWQQAEQEDLQLKRRATSSSLNVPEQGSSSAVFYRSRTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q080</accession>
    <name>A0A8H7Q080_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_006407</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q080"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15545">
        <property type="entry name" value="PHD_BAZ2A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028641">
        <property type="entry name" value="RCC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46207">
        <property type="entry name" value="PROTEIN RCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46207:SF1">
        <property type="entry name" value="PROTEIN RCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="74"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="133"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="185"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="249"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="357"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="428"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="476"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2183401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="511" mass="55050" checksum="9E89EAB8B556E905" modified="2022-01-19" version="1">MAEIQAPAEQSSGKLLICGTTAWDVINRKNKATEETESQILLSPHLVRDLIDVKIVKAITGPTACHSVVISEKGHAWVFGRNEKGQIGNKTKICQDYPLKITSVTENRSALGIRKIVDAATGRNHTLLLCDSGEVFACGDNRLGQLGLTDLNDHTTFKLVTQLVGKKIVQLACGADFSLALTDKGQILAFGSQEYGQLGNGTDGQFIKSAGKMATSPQPYPLLVKGLQDKHIVQIACGVNHSLARDKDGYVYSWGFGGYGRLGHGEQKDAMVPQSISFFASSSEMARCTEITCGATCSMALDGQKQVLLWGKWKNTGDGSSGQPWMQPKYIYDLNGWKMKAISAGSQSLFALAAEEATAIAWGQVQSSELGFGEESAVKSATRPQKIEPLEGITLTRVSGGMGHTMFLAQPNDKLQDFPKWPVLPEFEGGCVKCSKGDNEDQILLCDKCDNPMHTYCAVPALKDIPEGEWYCDSCHPNGHSPDSEDEGAAKTGKRGQDSGTGKAGKKQKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0U8</accession>
    <name>A0A8H7Q0U8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_006742</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ORC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0U8"/>
    <dbReference type="OrthoDB" id="346673at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="7">
        <location>
            <begin position="321"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="8">
        <location>
            <begin position="547"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="87"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2183731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="617" mass="69432" checksum="08709413F56FCBBB" modified="2022-01-19" version="1">MDMPELIVKNQGDDEIAQHFVNTVHPKAAKREADIAKSRKLHNPQSGLVGRRRYYNAGLTVASTELAEEVPSLLKQHDDAEQILLHAPNRLNQVQNNTDEGSEVGNGNGNGNGNGSGSGSDKENGAMGRDMFGINKVKGKGVESMMKKAMATETKPPRARKQGFLTKVNSRLAASNDTRGADPSMKAGKKGNMEKNAESTQYKRKKAASNPDANENELTQTRKRKRQFERQVQKLDEKEVENSDTSESDGEQEEEEAEEESDEEQVAPKDGLEKDGYERYFQDLHTSNKTSNNTLSQLPILDPQEFKEKLSQAPKKHAKDIEILHSLHERQFPQWQFELLSHYNLLFYGYGSKRKLLTKFAQSYLNDGPLVVVNGYFPSITIRDILNKLSVDALGINAPTGSIQDHVSLIMEHFQRGENEYDNIYLLIHNIDGVNLRNERVQTALSILASCPNIHIIASIDHINAGLLWDSIKIARFNWIWHDATTFDNYLTETSFENTLMVRQSEIGGSRGVNYVLASLTSNARGIFKVLAEHQIIEMELATMEGRGDESVGLTYNAYYTKCREAFFVSNDVTFRTQLTEFRDHKIIQSKRSVDGTEIMYLPLDKSILTSILETIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1P7</accession>
    <name>A0A8H7Q1P7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Nep1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_000712</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1P7"/>
    <dbReference type="OrthoDB" id="269804at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000003">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2184799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="30376" checksum="6D7F8D153D13BD08" modified="2022-01-19" version="1">MVAMDTTSRKRSVDESNSDTEQAVQHKNSRIKVGQTRQVDASLVPQTPKVPKTLTQKENARRLIVVLEQATLEAFKVGKDKDARFQLLNADDHINILKKNGRETYEARPDITHQCLLTLLDSPLNKAGLLQVYIHTQKNVLIEVNPHIRIPRTFKRFSGLMVQLLHKLSIRSVNGSEKLLRVIKNPITDHLPTNAHRIALSWDAPTVRLSEYLPQIPEDQSIVVAVGAMAHGTDDFADSYVDEKIGVSEYSLSASVACGKIACAIEDMWGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4A2</accession>
    <name>A0A8H7Q4A2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_002677</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4A2"/>
    <dbReference type="OrthoDB" id="27823at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032185">
        <property type="term" value="P:septin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018808">
        <property type="entry name" value="Muniscin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF54">
        <property type="entry name" value="SUPPRESSOR OF YEAST PROFILIN DELETION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10291">
        <property type="entry name" value="muHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD" evidence="4">
        <location>
            <begin position="609"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="488"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="136"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2186239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="863" mass="95428" checksum="28D581182098B058" modified="2022-01-19" version="1">MTIENNTYAEPSRHAQFVEAFLTEKPKDGIDVVQSRLRKGQKLTDELAEYFRERAAIEDQYARSLVKLSRKTFISDKTALGTMQPLWHKLFDEITDIANIHGNMAQNITDDVERHIRSIWANDKNLTAIRNMEPSMARYAKDYDELQVKLQKHQKVLEKAGGGKKQEEAQNKLKAYQQNLNDLKRRWSQEGPAYLEACQAIDVHRFNALKESIQAFEKMQAEQMSKRMEHADSVNVAALTLEVENELNDFTAHFSNLRKLLVELPTEPGLVEAVASDQPSTLSTPQPSFHEEPSVRSNDDAASIQTNVKNALKSLRRRTQAGVARSNVDGTTPDHLAEWATLDFNSGSGIDQQNDLEKSYNDSSLAQSFVSNGSINEKHAPAQSEAGTSAPAQLLTISKTPSLSESWSTLGMQTHKTQVDEEGYSIPPPDRTPWNEAAGATLNENETDDILDNSSIMSSNRIKVDIMNETVKEDAEASHALTRVATILKEKNTPSPGKRPRGRRETLRLNQMTNRSTSPQQFGGSSSSLDVSNFNKASISPVSADFSDTNLTVATAGANAGFISPQLNPFDPSGAAVDKAPVNPFELESRDTFSASPDSGQIGDADTKAPHLKADIAETVHVLTKAGEVVRSMITGEISLAYRGHAMDKPVCFRITNTEHIDRLVPNHTYISEVDGHFGVFRINEDMFFKAGGNSIVCLKYQLKMQDSNAAPVAPLIVKPIWKLEDNMSMLLIKYNGSTEGLTTDKDIVLENMSFLVPVDGRVTSAQSMPACVWSMERQKLLWNLGDLTIAAGETPEEKKLMAKFDTQSKGTPQAIAIKFTSSSSSITNITLAQDVESEGEFYWAHVESVQRRTTSGKYLAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4M8</accession>
    <name>A0A8H7Q4M8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Non-specific serine/threonine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_002176</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4M8"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000768">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="12">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="12">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="436"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="155"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="241"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="718"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="847"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="718"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="742"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="768"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="779"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="869"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2185741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="900" mass="99375" checksum="AD69F730D17B7AE0" modified="2022-01-19" version="1">MGNSVSSGPTSSSSSRSPYSQPSANDSTRFYSSEKDRDWRSPALDSRPSMSSLHPSAMGSPSIKSLRRKGSNETMGSNRLFMHSNASNASMASKASKASSWRKRYGDRILDIGKPTEFEHGIHVEYNKKNGKFMGLPDVWQETLPSDDILDTNYINPHLVPSSGSKAPPPPRTTSNRPANQIGDPYNVKHNVHVQVDKSRVGFTGLPSGWAEILEASGVPKDIINQHPQTVRKLMQLRMPGSLQEEQKQQQQQQQQQQQQQQQAAAAQKIKKSPAAKTATKETTTMEITRKELPKITSDVVGETNKDEEPPKPSISKLKSRTSSLPFGFAPPTRSRSSRLTQKQSITDLKSTDTVNDMDQTSLISPDSPLESPISVDLNTKSLRTEHIPKPMADKNLTVDIGSEADIACVEPEDEVALDSENLGDIVDSTDPHGIYTNMTHIAEGESGNMYAAKHSLTNRTVAIKIIPRSAEAKMKKIRNELTTMKMSRHPNVVEYITSYLTDTELWVVMECMDVSLADIISVDPEGVPHLSEAQIARITRDILRALCRIHRLHRIHRDIRSDNILFNARGEVKLADFGHCAQLSVQQPKRSSVVGTPYWMAPEVVKGLEYDAKADIWSLGVLLIEMMDGNPPYVEYPPLRALFLIASNGLPPLKDESRWSENFIDFYKQCVNPNPSERPTADVLLKHPFVTSGVGNTKDMVELIEETRRLELLQQEAEEAEEADEVDTDTDSVVDGGANDHEEETGAEEKEDEDETPAAVEVLQVMEGDKATEDPKVETSNNEIATTDSVAKKRESSSKANESLLPEKETETIPVFTAKDNAPVDSTNSNFMTEMMTMFDGIVSSTSPTSVGGPGVDDAHHTAKETTASDDSESDMEEGIVKRIQRTTILTSDLTVSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q568</accession>
    <name>A0A8H7Q568_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q568"/>
    <dbReference type="OrthoDB" id="2550114at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2186093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="173" mass="18324" checksum="58457BFBDDCE9EB7" modified="2022-01-19" version="1">MSYLPKDIFAVAAAGYLTVLAVPQLAFPEMALGTWGPQARSETQSAAEEMLARTVGLCQLTLALILVVGTGTLPITADGRRPATSKPVLFISATYFAIQAFLAMLTAKNPPLGGAGHQFKASSIINGAIALFGYGSLLFNADKHNLNENSDHSKPRVGNYPFKNVESEKAKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q621</accession>
    <name>A0A8H7Q621_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q621"/>
    <dbReference type="OrthoDB" id="2281363at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="19"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2185704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="152" mass="16917" checksum="8F1597C59B0834E6" modified="2022-01-19" version="1">MLNPSRKMTIQVSESSIKPRSRFSQLEDAIICEGVAKGLSWGEISAQLPHRKRATCFNRYYTLMGKRRPHKRRASSVDSTTTTSSPPSPPLTPDAQTNNFETAIHKKNTNGLSTSRIPTSRPASAYIYKPSQPSSIQTKPCSSLFRRKSTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6S4</accession>
    <name>A0A8H7Q6S4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_002798</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6S4"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF3">
        <property type="entry name" value="HOLOCYTOCHROME-C SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2186360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="245" mass="28224" checksum="F090AD4598A45A24" modified="2022-01-19" version="1">MAPSPMTPPPGCPMHKAEEEKKPAPPPGCPMHNKDTPVTDKLNELNMMPNLGQERQADQVIDLPTERTTSSIPKIAGQKEKWEYPSPQQFYNALRRKGWETPEDHIETMVDIHNFLNEEAWNEVLKWEAMRECPCDEDPYLARFQGKPQQISPKARFHTWMGAPRPFDRHDWYVMRCGKETRYVIDYYEAPEETPGVPVFSLDVRPAMDDAESIMTRFKVAAKEKWDEWFPSSEPSSSSAPNTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6V3</accession>
    <name>A0A8H7Q6V3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002781</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6V3"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11064">
        <property type="entry name" value="CYP86A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24296">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2186343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="60327" checksum="B3FD82B5F0DB0E03" modified="2022-01-19" version="1">MSLSVDSIRKRFVNSSPAVQYAVAIGGASTAALSVLALMYPDRAIFDEARPDIPQRSGWPLIGSFPDILKNMDTFHHFALKGFEDLARTTTMSNLGIPRNIATSDPRCVEHILKTNFSNYEKGPQFRDGMNALFGHGIFNTNGDEWKFQRKTASQIFNVKNFRDHFTDVFVDELDYMKENILDPLVDNGKTIDFHDLMFKFTLDSFVLLGFGEELGALRKDGKVPFAAAFDAAQVNTFRRMMLPYWRVREGLAKVLMPWKDSMEDHIKVVDEYAADMITKRRKEVEKGEEHNDLLSRFLKSRDDRGNLLNDQQLRDIILNFIIAGRDTTAQALSWALYQLMLNPQVEEKLVKEIYANISDEDEHNSTALYEAIKDMKYAHAVFYETLRLHPSVPANQKYALEDDIWPDGTVIKKGDYVVWSPWAQGRLEAVWGSDAKDFKPERWLNEEGELKRENQGTWPAFHAGPRVCLGQNLATLEALVALTLLLKKYRFKLVPGQDITYQVSLTLPMKNGMNVTVNQREKPEIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U6P9</accession>
    <name>A0A8H7U6P9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U6P9"/>
    <dbReference type="OrthoDB" id="5563016at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF18">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="579" mass="63671" checksum="BBBA0F460C0CC4A2" modified="2022-01-19" version="1">MTAVMQNNPGIAVADDEDDVALAAFLAPNWGRFDQDKLAFDIMSYRHTTPDPYADYNMRQRKISNGEVQVQKSTSTPVLRSRDRQSTPPLYQQPKHSIPARREESPANRQCSQPRRDESPKSRSPSAKSRRESPQSRSSDSSRDISPGSNRRPSPHNNARPAQAYQSPSDHKHHHSLPKRTPTPIPLLTQSSAQFTVQDRRPSLNSVKSATPSIRSEMSMNTKLSLSKRLRRVFSMSSLSLKNNGSSTSLVSTADSDIVPKASRSSSAQSIASQQLPATDSESPVNPTTSVSTPPKSSSRRRSLVTLSNIFSRSSEKQKAEQVEPTVQAVIVPAQTGANQRHSAADLRKMINEQPGPPVSNRATAKPDRLKLDTSLESIQQSAKTSLKQTRRTSSSRPPDSPSSISSASRSPVTPPPHRQGPKGHSSYASAVASSNARPRQSSINSNSSARADYFTSADLEHSDILVPPPSTGLNSLPLHGSPRMKPAPQSNTMLAEPTSMREIPPPATARTRRLGFSTSITVHETFSANEYDRRCDPNVTCCKLTPEFAMRIKQELNEYKLTGMEVHIESRQYTHFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U753</accession>
    <name>A0A8H7U753_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U753"/>
    <dbReference type="OrthoDB" id="2394678at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="191" mass="21523" checksum="611CC4409D1D649E" modified="2022-01-19" version="1">MPLPPAVWPPQGRRKQHSEGCLEKTNSSAGFSYRQLETSAIRWPTNNTHRHLSSSSLYNLSSPDSLYHTTYSTRSTSVKKSRHLQSTKRRSAFTRPLPKPEPVSPVAFNSPPPPLQQFSTKSSESYDLYDQEQQELPQKLMSDQAIMDDLEAWTCSMRTTCAPGLMSPPGSPLLSSFEDLPSFEEDFVLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7H7</accession>
    <name>A0A8H7U7H7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_008226</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7H7"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="3">
        <location>
            <begin position="331"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="5">
        <location>
            <begin position="576"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="4">
        <location>
            <begin position="673"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="2">
        <location>
            <begin position="798"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2171500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="946" mass="106775" checksum="2CC5B3474ABE7E02" modified="2022-01-19" version="1">MQHYPVRPPPQGQYARPPTTPPTQFHSQARPPPSSNMIRPHRPPPPPPPPPQSPDNVLQHQMENMSLHSNSPRPRGARAKRVFHPDGLSSGGPVRPTVARPGMVSPIAQGFPNVPRPDMKSAQTMGYPSPGAPTTRPPEPLPSQPKSRIDPNQIPSPVQVQEQDQQLFEGKEYGTCSKTSIPLSSTHVRVVDQGNCNPRFMRVNTTQMPASESLLEQSHLPMALVVQPLAKLRHDEEPIPVVEMQKEGPMEEESLFVTFVASIVMVYFMFLCPIIVNGIPTNSCKNLKSVPDEYFCNLDMSGRRTDYEYRPELRDGIVEYIVPEDYWAKPPQPLHYLFAIDVSWNSSQSGMLTTFCKTLNDILYDETSPDRLPKGAKIGIMTFDSTIHFYNLKAGLEQAQLMVVPDIEDVFVPLNEGLFVHPEESREVITDLLSNLPAFYAENRNSVAVLGPLVNSAHSSMKECGGKLIVLQSVLPTKGAGTLRVREQSKRTNEEEKTLLTPQDSNYQKWGNELVEAGVSVDLWLFPLQAHMDITTMGLLATLTGGDVHYFPNFNHNRDGAKLAFDMRHSLMRETGYNGVLRIRCSNGLTVHDQFGNFTMKNTTDIELAGIDEDKSIAFVIKHDEKLDTKLEASFQCAMLYTTASGERRVRVINLSLPVTDNIANLFRNAHMDVTISLFMRQAVSLAGTKSTQQLRDELTVKCVKILAAYRKHCAYSSSPGQLILPDSFKLFPLYTVTMLKSLPLRSSSNLDIDTRVYNMRYTKSLGILEQMTLLYPRMFPLCHLEADIGELDETGSIKLPPAMRVSYERLRRDEAYLLENGQYLYIWLGRDLPPHYLQAVFGVGDPQHIDPRQGLPHIDSTESIQLRKFLGAIQGQRAWYMPIRIVRQQLDMELDFANLLVEDKNNEQMSYVDYLCAVHRQIQTEITQEKQDNVMASASYWTQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7L2</accession>
    <name>A0A8H7U7L2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7L2"/>
    <dbReference type="OrthoDB" id="28939at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009563">
        <property type="entry name" value="SSSCA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051888">
        <property type="entry name" value="UPF0148_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16537:SF1">
        <property type="entry name" value="PROTEIN ZNRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16537">
        <property type="entry name" value="SJOEGREN SYNDROME/SCLERODERMA AUTOANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06677">
        <property type="entry name" value="Auto_anti-p27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2174351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="306" mass="34166" checksum="5B4485CD347A4685" modified="2022-01-19" version="1">MQDTDMYERASEQIGSYMLQGWILTDETCQRSNCHTPLLRSRDGQKKICVVHDTVSPPKSKNQPISERSFQETPGTADNTIAKAVDIESDDEAEQFIQRVKNSGEEKNSFAAKRREQSKRASELIGQKLLQQWALVNDICPNETCYAVPLVRDPQQRLFCVICQQTYMTEAAYNKKIQNQSNTHSTLTAAAKTDAQPNPITTQAISKDVDLRDIDLDDPELLESQLKMLAGDASKQKDADPAPTKMSQSYSGSSTAGRTELLEQMKEKVDELSLQALKARDPAELVKLFEAIKAGSEAIKAYEKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U812</accession>
    <name>A0A8H7U812_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U812"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034261759" evidence="2">
        <location>
            <begin position="27"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="248" mass="23980" checksum="57A565FDBE9C68E7" modified="2022-01-19" version="1">MARLSATRLILLLFIALALFNMSVLAQNDPGNSVSDGTDSTDDKGDSGAGSNNDSNDGGDDGDDGDDGDDGDDGDDGDDDQDGSDDSSDPTDNGDDSNADSTGSGDDSGSDSTGTGDDSGADTTDSGDDSGADSTGTGDDSGADTTDSSGSDSTADSTDSAAILPTDSASTSVPAASSLSATSVISSVLPTIASGTAFSTSSWASKASSSILPSSSIVPSKASGANTNTVKLVSAFISALVAVVAVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8U5</accession>
    <name>A0A8H7U8U5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fumarate reductase</fullName>
            <ecNumber evidence="6">1.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_005676</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Irreversibly catalyzes the reduction of fumarate to succinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="6"/>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8U5"/>
    <dbReference type="OrthoDB" id="10252157at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF7">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034278155" description="Fumarate reductase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="7">
        <location>
            <begin position="5"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2176436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="432" mass="46801" checksum="4A408C7EC8738F1D" modified="2022-01-19" version="1">MSTRVIVIGGGLAGLSAALEAHAAGALVTLIEKETKLGGNSAKASSGMNGVQTASQHMLNISDTKLQFMEDTMASGGSLSDRHLVARLVEDSASAVEWIEQQGVPLRLVSQCGGHSCPRTHRIAPDEFGRAAPVGWGIMSALQRKIQGSDITVLLSSPVKRLITQNGRVTGVQLGDDQVLQTDAIVLTTGGFAGKPVHGDNSVLNEFAPKTATLATTNGPWATGDGIRLGQNIGASIRDMDKVQVHPTGFVDPKDPEATSKFLAPEALRAAGGILMNQNGLRFTNELDRRDLVTDAIFRSCEDYQTDRNKTAVANLILSQEAVNNYGPSTIQFYENKGLFRRYSHVDDLAKAMSLDPKFLDYQLKQYDHHAEKGYDQFSKTVFPSRMSDSSAYWLGKITPSRHYTMGGLRFDAYGRVLKETGPESYEPIEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8W9</accession>
    <name>A0A8H7U8W9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_000034</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8W9"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF227">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2172687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="341" mass="38254" checksum="2541160E35C76EED" modified="2022-01-19" version="1" fragment="single">EFCYAFQKNGFKGTGCYAQQFCLNRKPETKRTKNMGKRNFELDQIPDMTGKVCIVTGGNTGIGKVSALELAKHNAHVILAARTPSKGQAAAEEIKAETKNDKVEFMKLDLLSLSSVMEFVKDFKAKNLPLHLLLNNAGVMACPWALSEEGIESQFATNHLAPFYLTTQLLPILEQSQPSRIVNISSLAHKSIIFNGLSLNKIQDKSSYNARTAYARSKACNILFTRELAQRLEKKNVKNLYVNSCHPGVVDTEIARYATFPFKQIIDWMKINPQDGALTQLYLSTSPEIEKKDIRGKYYVPFASEATPQSHSTSQKNQTELWDYTEKILREKIPGYTDAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9B4</accession>
    <name>A0A8H7U9B4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">30S ribosomal protein S3, chloroplastic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">40S ribosomal protein S3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_002901</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9B4"/>
    <dbReference type="OrthoDB" id="10248446at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000004">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="10">
        <location>
            <begin position="10"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2171279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="232" mass="25632" checksum="B9E426C214524D3C" modified="2022-01-19" version="1" fragment="single">VADGVFYAELNEFFTRELSEDGYSGVEVRVTPARTEIIIRATHTQNVLGEKGRRIRELTSLVQKRFKFPENTVELYAERVQNRGLCAVAQCESVKFKLLNGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRAARAKSMKFTDGFMIHSGQPTRDFIDTAVRHVLLRQGVLGIKVKIMLEYDPTGRAGPKKNLPDIVSILEPKEEAPITEPISQDFSKPAAPAAEAPAQPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9E4</accession>
    <name>A0A8H7U9E4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tubulin-tyrosine ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_009030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9E4"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="49694" checksum="FE60C2A64D1BA983" modified="2022-01-19" version="1">MPLKARVHFDQPYTQELVKQSLNEHSRFEWDIEDNVTDDSIPEGELIHLQWLEYELIDWGVLAAKSTQTMSNSYCIRKGLIRKSQLAYNMTKYISKHPDTVLKTAIPETWLFELDHIDYLEEAMNDVFEVEQDLADNESKENDRKAFIIKPSMANKAAGIHIFDTMEGLRSLFEKTKINDSDSEEEIEDETSEDGEPGGDDSEEEEEEYESDDDEGDLSQIREWVIQRYVQQPLLLCGNRKFHVRAYVLAVSNIQVYLYRDMLALFALKSFDDADLSDQLAHITNTCIQTEEDTFVEDESVRLFWDLKNEGVAEEDLESMFQQMQTVLGDIFDACTSEMTTFQAMPNAFELYGVDFLIDQDKKVYFLEANAYPDFKQTGAKLQHIIGDLFAETVKLAIDPFFQTAVDSTDESKTACSNGFVKVFDKQLLGPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9X7</accession>
    <name>A0A8H7U9X7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_004749</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9X7"/>
    <dbReference type="OrthoDB" id="5599552at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="6">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2172208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="240" mass="25585" checksum="D7A7707248010C6E" modified="2022-01-19" version="1">MQVVQQPQRARMCGFGDKDRRPITPPPILKLTVTDSEGFPLKASELDISFLIVLCDVWAADASAKVNLVIHPTAAPMLTPSNSKAAAAAISTSSQSPPGVAGTRANSESSTADNPTPAATRNLIGSLVASAAKLFDTDDQLGIYFVFQDLSIRTEGTFRLGFSLVDIGSPYMRSTNEASSRVLAQAFSEPFTVFSAKKFPGMIESTPLSRAFARQGVKIPIRKDASKTKKDGTAEEGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAB7</accession>
    <name>A0A8H7UAB7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAB7"/>
    <dbReference type="OrthoDB" id="2275843at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034485883" evidence="2">
        <location>
            <begin position="26"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2175535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="173" mass="17714" checksum="B216BD33279F2082" modified="2022-01-19" version="1">MKHHEYILIALSLCITSFALPIALADDVSSATGTGLYSIQTSPPKPTNVCTEACLQPQVTPKCPANCPTSCIYQQSTDPCCPDSMEAVCADNISTGSTPTGTQSSSSPISTIPSSLVAVSSSASSSLSPMDSSSASQSAATIHNNAASTDMKSNHALYITTALVAIIFAALLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBL5</accession>
    <name>A0A8H7UBL5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF1308 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_005037</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0415 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBL5"/>
    <dbReference type="OrthoDB" id="441890at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010733">
        <property type="entry name" value="DUF1308"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041076">
        <property type="entry name" value="DUF5614"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379">
        <property type="entry name" value="UNCHARACTERIZED DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379:SF0">
        <property type="entry name" value="UPF0415 PROTEIN C7ORF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07000">
        <property type="entry name" value="DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18474">
        <property type="entry name" value="DUF5614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5614" evidence="4">
        <location>
            <begin position="32"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1308" evidence="3">
        <location>
            <begin position="250"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2173619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="50421" checksum="66446103305AB935" modified="2022-01-19" version="1">MAAATDEDLANKVNALRHACLRIKHDVDQWLEQGHIDGLYRFDQMVTAELKFINKLVGLPLKEDQVKSSNLSYLEAVHKAMLQSNNVVGVMKDFFVSDTPIHYSGRSRGIVKVDVVAENGLVWIRVNARNAKGLRHDIAGLEESSSGSSDDGEEDGQEGAIGDNLPLFRKAKALMASAERHLVHFQKPIVVYAFMRISTGDDPYVDEQIIDKLPNLGITVYVKSDKALSEVYRQALNNSHQETQVTTDKLNLDVSTVMAVISEMVHRKGITPSMVRGEALELQAAHELSHPLLPELAKILDKKQLFVTQSAMDKLNTIVPVVGGAKERARFEYMLGKNNEVDLWINYPADTSYLRLTIMEDKPTARFLELLQPPQGQRYKRINNGRRIRSKFNEFHVNVFGTGDNNRMTTVTSISWMGRALADAGLLGVAIVEHEPRSLAEQKIHSGDTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBT0</accession>
    <name>A0A8H7UBT0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar ATP synthase subunit E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003549</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBT0"/>
    <dbReference type="OrthoDB" id="10263003at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2179766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="26097" checksum="29B95D42A939B18D" modified="2022-01-19" version="1">MAAVRALNDDEVFNEMKKMVSFIKQEALEKAREIKVKADEEFNIEKAKIVRQESLNIEATFERKIKQAEVQKRIAQSNQINKSRLRVLQSRQHMLDELYEEARSKLPSVSSDSNKYPALLKDLVLQGLYSLMEAEIKVQCRKDDVSLVEKAITEATKEYEEHMGQKINATIDEENMPSSNAGGVILSAMNGKIKVNNTLEARLTILEDGMLPQIRVLLFGHSPNRAFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCY3</accession>
    <name>A0A8H7UCY3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_007646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCY3"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2176992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="226" mass="25640" checksum="8CC1ECA40B4258A5" modified="2022-01-19" version="1">MAPLQVIGSGWGRTGTAAMREALTTLGYDVHHMIVIMSDPNSDKQTFIDAWEGKEVDWNKPFDKFNAAVDWPSSTFYKQLMEVYPEAKVIHTTRDAEAWYESCKNTILPVASEEMAANMPPHVSAGQQMVRTVVWDGEMQGKMVDKEAAIQMFRDHDEEVKRIVPSDRLLVFETGKDGWEKLCTFLGKDIPDTPWPHVNKTDDFRKNIERFKSGRKPEGFAPVASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDF4</accession>
    <name>A0A8H7UDF4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDF4"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47232">
        <property type="entry name" value="TRANSDUCIN FAMILY PROTEIN / WD-40 REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47232:SF1">
        <property type="entry name" value="TRANSDUCIN FAMILY PROTEIN _ WD-40 REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2178880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="506" mass="56665" checksum="8B4FE71AED7849BB" modified="2022-01-19" version="1">MPFDEIPELIPAGLLASSFLKATATNDQQSDIVASTSRQLSREKTTEQSHGSSHSSQTSLGRDSSRRLSRDNIETSQSSADRHKNNYDSTSHSGSASGSDSGKETRIDAEMLLQDPMKSQDQIRKMLLKLEKLRIRHERYTYKAAQTAKAIHKTSRNLERTMRIMTDVTFAKYHNLRSSSNRPPQNELTEEPAQKSQKRDRPEAEPLNVKIDNYNRKPRSLLYNIAPTSCSYLYKFLVSTTMNGDIHTTNCETRKMITTVPQTDLLISSWAEDICWATPQTLAVAVHYRRSHSDEKQLCLVNIKDNGQYEASVQAFAHKPHATRVNVIAHVQHSEHSESSDGKISSTLVTGGLDSPLMLWKLTTTYGQTKFLEPADSLLGSKHTSHVLAVSYDAKARRIYSGGADCKLAWTSLDATTSATGNCHFGDRINHILTNQVNPHLLMICLAGVKDQMRLYDVRMQPNSATVLILGCSERVHTSRFIRPAWRPNSRIVASGNMSGNKIYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UE20</accession>
    <name>A0A8H7UE20_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex subunit NOP10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Nucleolar protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Nucleolar protein family A member 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">snoRNP protein NOP10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_003400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UE20"/>
    <dbReference type="OrthoDB" id="13807at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904874">
        <property type="term" value="P:positive regulation of telomerase RNA localization to Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.300:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2178147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="64" mass="7426" checksum="244223C2F5C0143C" modified="2022-01-19" version="1">MHLMYHSDAKGNRIYTLKKITSDGKITKSAHPARFSPDDKYSRHRVTLKKRYNILLTQLPAKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEM9</accession>
    <name>A0A8H7UEM9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Condensin complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_001668</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CND1 (condensin subunit 1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007673">
        <property type="entry name" value="Condensin_cplx_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024324">
        <property type="entry name" value="Condensin_cplx_su1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12922">
        <property type="entry name" value="Cnd1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017127">
        <property type="entry name" value="Condensin_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="6 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 N-terminal" evidence="13">
        <location>
            <begin position="78"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="12">
        <location>
            <begin position="1047"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="463"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1280"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1324"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="500"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1340"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1353"/>
            <end position="1367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2178822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1367" mass="155343" checksum="F954093BBF417B23" modified="2022-01-19" version="1">MDLDFNLHDELLHLQEDSIENYQITNEVNLQGRNRQEIEVYLNDIVDKIEVASDTIAEPLVFDKIRSFIKNFDHVKPKYLARLLDIVLSAFRHEVKATADDIEANEKETFATHKTILEMYGFIVHWYLITIEDKASSMAGKSKRGNKNKAQEDDINTWDWTPQKLKSFELIAFMLEKKISKIWHLNPERDLLLSLFTKPAYQIFEISTSIKNAKVKEIIFHVLGICITKYGQAFAAQTTIIQDLQYWEHSAEPMAEFLQALYIRHDNRQLSDEVLRDISNKEFKDNTSKEVKDTPNSKTFALFLVKMSELCPKIVLKNMGLLIRQLDSESYTMRMALVEVIGNLIIDMATKEEHASQKDQINGFFDVLEDRMLDSVAFVRSKVLQVYLKILDLKAKFPKRRHALGALAIRHLEDKSSSVRRYAIRVITQLIKTHPYIMYGGLLDIDEWRERYDELGEQLSAIKAPQELQELPDGSDSPDGSNGAEEVEADQDANSRSPNEEEPETADATEDVEMDEADAGQQENADDDDTNVDTETDPNEHKTNDEAQTPVDQPDKANDSVSNSVTSADEFHRLTLAHRFNADAIKFISQIHTAIPFICLILASKAKIEVLEAMDFFVTAWNYKIEASVEGIKKMPHLIWTKDNSDEGKGIKTKLLECYKTLYLEMDANLTEKENINTIARNLVQLTFNASLAELTSLEQLLCTLMSQNNIPEQVIDKLWAVYSYSKREIPKPQRQGAIIVLGMLAKAKTEVVSEKIDVLLKIGLGALGRADLTLAKYTCVALQRLSGIKTNDKGKALHEGVRYSMDHAIFRKLKAMIEEPSSSSEWYAMTEQAINTIYALGEHPENLCAEIIRTKTIEVFGIADTTGEDSLMEEKQEDTNAVDDAMQVEYDVSVAYLQPSPKAAVYTDSVRLSQLCSILGHVAIKHIVHLEIIEAAWKRKRRKADDKAQAGMDDELEQVGGNADDDIGDAVSFMREREILFGNDSLLARYGPLLTEICTRNKVYTDHNLQITATLALSKFMCVSSDFCESHLQLLFTILEKSKNPVIRSNLVIALGDMAVCFSTLIDENISFLYNRLADEDTLVKKNALMVLTHLILNGMIKIKGQIGEMAKCLEDPEPRIADLAKLFFSELASKDNAIYNNLPDIISNLSNAETRIEEEPFRKIMKFLFSFDFAEKDKQAENVMDKLCLRYKNCDDERLCRDITYCLSLLPFKTEKSYHKLLGYMPLYQDKLHEETVYKLFTEIIAKGKLQKSQKPEMKTAIEEFEAKLNACREKGTVEGADEETESAPTPVVPAKRTKKTRSSKILKYNLSNCNRFHVLTKAPLGQSTENKESPKTRPSRRTAKRRAVVEDDSDNDDDGDFNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEQ7</accession>
    <name>A0A8H7UEQ7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_007845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEQ7"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="17"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2177188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="588" mass="67234" checksum="91FF1CE86E47B5E0" modified="2022-01-19" version="1" fragment="single">MSTDITLPTSDRQVTSQDLETFQTWLKDHGAVFDDLAFGADEDGMNGVLLAQDLSENQTYASIPFNILITEPLVREKYPALHKLSSRAVMSLFISNEWQKGSESLWQPYLAAIPNRIMTSMQFNDDDMQYLENTNLQLGTINRREFLRSEYEQILQIIPESERRGFTWDVCLWGYTAISSRAFPYKLIDASASGEMMVPLADSFNHDPSVKVAWSGRGTKTNGVLDLITREPKHAGKQIFTTYGPKANEECKLLIGYGFCIKDNPYDYVVLKPNFDRDPNAAAKYHILDSCGLLIATENNPEGKPTFYLTRDHLPADLLAVFRVLIMNETETTAYMQADHRELLDFVGFRNELAMLEILAAMLAQKYQSLTTNEYDTSSHLHPWQQSALYYREGDDDTIVSAFYECFPYKLRCQLLERMRSNFAAGRIAGFSPLLGITNSDDKALLSFNYSQDREEGQAADTSFLITIAEAKRLDPDYGAVLEEALPSEEIEEFGFDSIETCLMLILIRERYKSQSRWRRFLNVVQNEAVEDGDDELLELYEQLLCPVFHKYPKEFDAEHFTFENFQWADLICRTYSLDIGGDMAIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UER7</accession>
    <name>A0A8H7UER7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UER7"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050680">
        <property type="entry name" value="YpeA/RimI_acetyltransf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43420">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2177218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="284" mass="32151" checksum="54D3FE4969ACFCB8" modified="2022-01-19" version="1">MSVTYTYTSGLDHTLRQLVEFNNVAFQGYLKDMTLSPEVFELFLVPQHVVHGLSVYMHTSDGEFVGLSRTGLRGTRAWVAGVAVVPEFRGKGTGKKLMAEYLRVLKESGRVKTVTLEVLKENPIAKRLYESLGFKETSTVHKLQFDGKMDATDSDGTLNITKGVDITLPWLQHEIDYMWSREWCCVSIKDNAQTVRYVNKDGEIVTSVIVYHDESKNTLSVLACAFSKNTSAKDLQTIFAHYCDQKAVTRIIVPYEPVDSPAMSLFEEIGFFEDDMEYIMQLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEU4</accession>
    <name>A0A8H7UEU4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_001866</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA8 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEU4"/>
    <dbReference type="OrthoDB" id="276296at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016680">
        <property type="entry name" value="NDUFA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017016">
        <property type="entry name" value="NDUA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2179017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18769" checksum="AB87F51DA5AD2B94" modified="2022-01-19" version="1" fragment="single">PLRPKLSPLMSATRDPVFTSTKFVDPTPAPESVPPVEEVGLTSAPLKSAAYFIGAYCKDYNNDFMLCKNENNDPEHCLKEGRKVTRCALDLIKKLRENCDAEFEKHWKCLDIKNQDYYQCRKEERQFNSCVFEKLGLQKNIPGSPEGKPQIHEKTNPIIKAHQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFH1</accession>
    <name>A0A8H7UFH1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFH1"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050933">
        <property type="entry name" value="Circadian_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23042">
        <property type="entry name" value="CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="65"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="197" mass="22589" checksum="2D3442922F1A7222" modified="2022-01-19" version="1">MSMKKIPISERRATYPLEHRLKSYSPEKIQRQLTDATAKKLVLNGVNILNNRSLDCDTAKDRILQRRETHNKVERRRRDIMNALIGELSDIVPTGSDLKTKSQRASVLRRAVQYIRWIQTENQQLRGQLNLPEPPVPELQFDDQDEHTSHTSRSPSVESGTTSDTGEDSRTVEIRSDPRGTFHTFSLSNDIEIQEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFS7</accession>
    <name>A0A8H7UFS7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_008998</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFS7"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="831"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="941"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="842"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2181415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="998" mass="113061" checksum="ECE8C733F48F66EE" modified="2022-01-19" version="1">MLAVTQVFCNLSGVGEDFQNWLAGRYGKPRNGKLTRSIALLNYMATSHVAISSAMNANFSQETIQSAAGSTVKKRKVSCLSCRSRKTKCDGEKPCAKCLLRGKSQDCVYAQTSGPVGRPPKNAVVNKMVRMSQSSDARQQFVYENLSFIGLTDWTKVLTSSYERDHISEDGSRLSDYITGIFSVYFGTGLRFEDKSDSGSLPQAVLVRGDTIFQMLDLKQHYNWLSAEGVGYCIGRISELKLENFKELDIYGNILRKDRSDNYFEKPRNSTYSETVRPSPLKSLNVQQALQLIDMFFTVHPWAPFVLNRTQVLQQYFTESSDPLLLAVMFGIAKFFAIQMKDGGVTAAAVQRGDTNEFLNYAHSILEETSAKATVPKVQAVVLFSYFEIIYGQAKKGTTLIALSYIMLNQLSLNDDYNYKHPNNVAGLGSLQLELLRNCWWCVYSNTVTGTIEFGQVPREAITPRDVPLPSINCQQSESFKLDVSANNTSMFIAYKHIYESFYVACAVSDLLARIWLVLPEPDRNMFRTVPNMRQLQKCPPQVVKRASVQEQIADILTDFEAFITAQYKKLSEQQCFQLEVTKVIFTIHNHFLKEELNTSEAMVYVSAIRSLYFKDDNYQIVTRIPSYTDKTERLPFLDRESVPAHVMAVVLPLAIDLIEHSQAFLNKREGQKDLLQKAPGWLILIAMETSGMILMLHIQQDQHPEEGVRRLEQILDILKLPQIYTDLELVKKLKGNIKRFLARWAPQHDAIGQATMMKFSNSPSPDYEDIVQLMNMAPNASSDIASSTEGSYGGSNTLDFEKYSETSDSTCQYSFMSAMPNHMEQNDLLTVPTSMGMPTPQSDLLNPSSSASSPQADRLSVPSSFYDDQFSVYESHGGSSMGSSAQVTPSNLPLDQFDDSQLFPLDFGIDSFDSSLLIQGQQQQQLQEQQQYEQYQQYQQQQQQQQQQQQEQQQQQQQQQQQQQQQEQQVPLFNLNQFNELQEFPLDLFVLDDNTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFZ5</accession>
    <name>A0A8H7UFZ5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA/pantothenate metabolism flavoprotein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFZ5"/>
    <dbReference type="OrthoDB" id="70224at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/pantothenate metabolism flavoprotein C-terminal" evidence="2">
        <location>
            <begin position="54"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/pantothenate metabolism flavoprotein C-terminal" evidence="2">
        <location>
            <begin position="178"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="328" mass="37071" checksum="9D1B493DBFC49913" modified="2022-01-19" version="1">MATMHDNQLLDNGQGVIDPDTYFLRNNPPSNLAEFEAKTSEFVQYHKERNTPVVLITSGGTIVPLENQTVRFIDNFSAGTRGSVSAEKFLENGYAVIFMHRQFSLQPYSRHYTHSTNCFLDYMTLTEDGKIEVDAKYAAAMATTLAKYQKARSNNMLLLQDFVTLSDYLFKLKSGTRIMATLGRSAMYYLAAAVSDFFIPTEKMAEHKIQSRDGALTLTLDQVPKFLKPLVSVWASNGLIVSFKLETDEKLLVPKARQALEKYGHQIVVGNMLTTRKKTVTFITQDSERIVSLSQEELDNDVEIESKIISELLKYHRAWISHGTLEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UG14</accession>
    <name>A0A8H7UG14_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl hydrolase family 13 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_000310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UG14"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000064">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000004">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056300">
        <property type="entry name" value="SusG-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23915">
        <property type="entry name" value="SusG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="5">
        <location>
            <begin position="18"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2184401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="580" mass="67439" checksum="9F44E6C283C7AD06" modified="2022-01-19" version="1">MQSDHIERRWWKEAVVYQIYPASFLDTNNDGIGDIGGILSKLDHIKSLGATAIWLSPIYASPQKDMGYDVADYRSIHEPYGTLEQVKQLIQELHKRSMKLIMDLVVNHTSDQHAWFIDSRSSRKSLRRDWYFWRDPNYDADGIRQPPNNWRSIFGGSAWTYDQDTNQYYLSLFLPSQPDLNWDNEAVRQSVYDDIEYWLDLGVDGFRIDSMNLMSKHQDLPDAPIIFPGEKYQPGDKWFASGPRMHEYLQEMRKVFDKYDAMTVGELGFTKDVKSVLEYVADSRHELNMVFTGDIVDMDFGKEGKYVRDDFHPDKLRSITNQWQTTLAQNGGWNSVYMDNHDSGRSLSRYGSDLPKYRSHAAKLLAIYLCSVSGTLFLFQGQEIGMANIPKNWTIEEYIDVEGRNYYNSVLEARGGDASRMQDVLDQLRLKARDNGRLPMQWNSSSNAGFTGSEIRPWMRVNDDYNLWNVENQENDSQSVLSFWKKILKIRKEYMDLFVYGTFEPIPAGTYGQNIIAYGRQDGSQKVVVLLNFSDKECQVQFDIMDTWRVLLSNFENYDCNNGKIVLHPYQGIILCNWDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIC8</accession>
    <name>A0A8H7UIC8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIC8"/>
    <dbReference type="OrthoDB" id="2417418at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="146" mass="16423" checksum="D08FB6FD326F7040" modified="2022-01-19" version="1">MQQQQPGYSNPPQIITHPPSEDEYVEKPATSVMPPHEADPSDPPFVAQRKSIEQRLGPNCPSGGYHELRMHYTNETLCCAFVLLPALCGYRGKREVSFGGRSSEGIGWPMITKCSIIIECSVYAQNAIQNFPILSYQNLERYFPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIR3</accession>
    <name>A0A8H7UIR3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIR3"/>
    <dbReference type="OrthoDB" id="2593073at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF9">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2181298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="497" mass="56921" checksum="84DEDD4FBBAE8287" modified="2022-01-19" version="1">MGDNLFDLTNELLFQQMQSSQQQDWALPPQQIYIPSEVNYLDDFLSTPFAPHSAASTPQPPQHQQYNQALQQHAPQNPSIDENGNPIKIRKRPGRKPNPQSPAIRKAQNRAAQRAFRERKERHLKDLEGTINGLRQQRAQMARELSACRDNLEAFRAENWYLKGVMLTLQFVCLQKHMSIPPHSPYLDEESLRKMAQSIPHAIDAYVTAYTKNNMAYKPNLGTENNFKVPAESSLSPSAFSMSNDNRSSFDSPELVRDFTPERSSRSEHEQPLFDEIKPEPSDDTDMLINPEPMDDEAVKQEQHLLEEDIQSTGRGVSTPKPAVNARNIEPSMSAVAAIQRIRLQLRVQKAFSDHAGQPELNIQPTILQLSIPHDPRIDLIPTSHMRDRMIIFRDQFDLDECFALLLRGAVCHGGDPTKAEAWELPAEFFKRYWFLTIDYDISRTNKWRRLQGLEDIGPTLQSKGSSQQPNIDTNTTVKARPKNFVERMCQEILRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIT3</accession>
    <name>A0A8H7UIT3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hcy-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008941</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIT3"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008898">
        <property type="term" value="F:S-adenosylmethionine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033528">
        <property type="term" value="P:S-methylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="BHMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051486">
        <property type="entry name" value="Hcy_S-methyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007020">
        <property type="entry name" value="PRK09485.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015:SF1">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE-LIKE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015">
        <property type="entry name" value="ZGC:172121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="7">
        <location>
            <begin position="35"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR037505-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2181358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="351" mass="38507" checksum="937E409E595F01EB" modified="2022-01-19" version="1">MPIFLPTSEAKLEKAQSFLSLSRGTSKTLCCFEPLCQRPPLETMPTIQLDAGMATTLERSFKQDLSDYLWSAGCLQNNPEAIKGTHALHLKAGAEIITTCTYQASFQGFQRAGYSEQEAVNTMLKGVELANEAKKDCGKPNVRVALSIGPYGAMLANGSEYTGDYHGTTGRELEEFHRRRLNVFFSDGNPQSGIDIMLFETIPCYQEAQAIQQLLKHVQYPVPVMVSFSCNSAHTVCHGEPISDCVALFKDMDQVIAVGVNCTKPRYISSLLQDIKTTVPNKTIIVYPDGGEEWDAEARSWVSGTKVGADAFGRMCKKWADQFGPDIIIGGCCGTTQDHIASITQNVTNHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJ63</accession>
    <name>A0A8H7UJ63_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THO complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_001003</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29024at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021726">
        <property type="entry name" value="THO_THOC2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11732">
        <property type="entry name" value="Thoc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16134">
        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="8">
        <location>
            <begin position="2"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 N-terminal" evidence="7">
        <location>
            <begin position="516"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="6">
        <location>
            <begin position="836"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1181"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1216"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1249"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1316"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1339"/>
            <end position="1462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2185090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1462" mass="166361" checksum="6164C39899E57CD9" modified="2022-01-19" version="1">MKTAMLYKQNKFNLSREETLGFSKLVAEIIANAFDADARQGEKEDVNYDDLIKVVLRNISSLIGSFHLDPNRVLDILLDIFIDQVKYNYKFFIQLLKQSPWIPGSTDNDGDIDMSNGTASQSQTPCPLISHLLGFKFRFYQSPDQMATTPTALYYVSALLIKNGIIRLEDLLPYLGPSDEEWSKEMDQYKEELNATIDAFKPLAAFEGDLEDYANPGVKSSNQKNVEEDETAKEDIAKKAPHDKAMLCNALLSIGDIKNAEILILKSEGICSRYPEIASLIYRLCDAIMEPAYKLYIPPGILKRDEDLARRGELSALIANRRLLSKESGKVDPGTGSEFPDPTIELTFNVAEDNLYHSKKRNTKIKFFFSEWADQLDKCTSHQHIIDKLLPIMRLAGYNNHLDPRFTKRLMALGRALLSRENEIAGIKTQWINIARECFLPAVSMSNCNPATSMLFWEFLDLLSLPERFSIYGYWQNEFYKKSLELKTLKTKMEKDTKGLVGKIGSLTVKPSGRQIGRLAHSNPTVVFEVIIDSIQRMDNLAFFIADACRYLQSLSYEVLTYLLIEKLTGSQGAGKMKKKKLKDDGINNEDWLKALSVFAGLLYKKQSIDPSPLFTYLLCQLKDGLHSEESMVATRKHQSAWENLIILTEFITKILGIEILGTTVTNYQVTATGCGPTVKAEAFQPLSPDHRKASKRTLSRFKEALTRNNMAVQLVALIAQLRQRCIFDKRVERDRLNTNLLGSMYDSVHEAFLQICEMLVTTFEGKEYAEMMPPIDVLYDEYKLNMDVGMHILRPALRQAVVEHDSANETTEEEHPAVAPLTVKVIEIMPENMFNSITAQFFTTFWQLSLYDISVPTEHYKAAIQKQRDAIAQSSQLSHREAAKVEAKAKDRIAAIQAELAQHEKDFDTTVARLKREQKHWFRSSSNRAAIIGDILQYCLHPRSVMSEGDAVFCAKFVAMMHKLGVWNFSSLTLYDKIMSENVAIAISTFTDHETTIHAHFIEKVFQKMTEWHKNEDVYVKKAQGDNLIGFQKVWTPQSGGQVVSKDDLLSHADFGKVMYKWHSKTNAVKCFISHHQQCRWSELIEISLQAVQQGLASGEAQQMRNSFLILKQFSSFFPRMKAHGEALVAELQKIVSSEKRDNLKTLAISHLGQLEKNRPTWISNDNFMSISKGLDPNAKAKEMAVEGAASPLPPPNRDLLSPNARMQSPRASPKHVSTSSSSSRAASPRRNGSHSRPQSPGGRNTKRGREPEIELPPKRVRDDDVADKEKEKAKDRSRTRVRERDRRPERESRDRENNKRGTESDTSSQIPNKRSKEVAESESANKRSRTTPNRSEQTGHHTPEPSKTDNSVDRKLSRPSSDHSKNAPTSRDRDREREHAKPERDAHAAPREKEPARDAGRDAGRDNARDGARDSGRDRNDRDKDRNRPPAREREKDRNAPNSRERDRRRHDDRDHRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKH5</accession>
    <name>A0A8H7UKH5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_006123</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKH5"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000374">
        <property type="entry name" value="3-oxoacyl-(Acyl-carrier-protein) reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2183128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="259" mass="27239" checksum="3211C80D18CA77E9" modified="2022-01-19" version="1">MSPITRKLEGKVAIVTGGSRGIGEGIVKNLAEAGAYVVVNYTSSNTQADALVAEIISNGGKAITVQADMGTIEGPQKIVDAAVDTFGKIDIIVNNAGVAGGIPLGSITAENYEKIYNVNVRGPLFLVQAAAPHLQEYGRIINITSVAARTVSPNITVYGSSKAALESMSRYWASEFAEKNITSNCINPGPVSTDMMNNYIATMAKEQSDAFLQDILSRALFKRVAQPVDIATVTTFLASSDSQWITGDVLGANGGMVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKT3</accession>
    <name>A0A8H7UKT3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcriptional regulatory protein RXT2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKT3"/>
    <dbReference type="OrthoDB" id="2405722at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039602">
        <property type="entry name" value="Rxt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013904">
        <property type="entry name" value="RXT2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28232">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RXT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28232:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RXT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08595">
        <property type="entry name" value="RXT2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcriptional regulatory protein RXT2 N-terminal" evidence="2">
        <location>
            <begin position="78"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2182514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="329" mass="37504" checksum="F40401E426980C11" modified="2022-01-19" version="1">MEPSESSVPSASKWLDNTESEESESEPIGLTDDCIYTCILIILDSFALKRWANSGEQSGGSKLRAPHSLSAQIDLVKNGKQRVVIKRRKRKFDEEFSDEEEDPYTQVKVEDILSPIETPSDIVHRPTLRRILKSPQMELLANTSMEFIESEKAFNKILSRLASILYCDDPQYLDVTYSRSASAQSGNDEYAMAVDSKSDDPEKPKSVDSELRQNGYQNGYEKDTTEDEEAQQILIRVRELLQENINFSNEYLNRLGSARAKLTRTSAQKKQLWKRLKVKAIEQERKRIQHLQQQAQRETNGAASVLSSLARNTSPGINMPLNPHMRDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKT8</accession>
    <name>A0A8H7UKT8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKT8"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22756">
        <property type="entry name" value="OTU_OTUD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF7">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="47"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2182529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="333" mass="37886" checksum="3975B3526FAFCC61" modified="2022-01-19" version="1">MGRRKGKGAPDGGTQALRRSRRLQKHFLADDGWGTQGLSRLLQELGYCTKDMAGDGNCLFRALSDQFYGTDKNHAEIRQEVCQFLRSNQQSYQMFVEDDQTFDWHMDNMENSGVFGGNMELAAFAKLHKVDIKIYQPGFIYIINGGDDVDEPRQTLHIAYHSWEHYSSVRNIDGPSHGPPEIQDRSIEKSSSSEPTKNEKEVMNACPKASLSQVREQLIAHNQDVDEAIEALYESEYQNHDSEIESQPNLEDPATDEVVSSPDKNGSDIVNDADTPSQDSGMDEKRKRKRVSARDRKMQAKIKQKQQRKAKKKAVEDEQQEAKVTSELRQLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UL91</accession>
    <name>A0A8H7UL91_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pre-mRNA-processing protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_002340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SNW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UL91"/>
    <dbReference type="OrthoDB" id="666364at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="5">
        <location>
            <begin position="202"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="357"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="535"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="409"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="548"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2185902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="607" mass="67643" checksum="663342FAF23384A7" modified="2022-01-19" version="1">MSWTIHSDLLRLHANIAIIYSILPKPQKQIDRPKESNKHEQQFNQLISQRVGQQAPPYGQRQGFKPRTQEDFGNGGAFPEIHIAQYPLDMGRKQEGKANANAGALTLQVDAEGKVKYDAIARQGHGQDRIVHSQFKDLVPLQERKHVDMDKLAMDRPSEEEVASVAEKTKAALEKIVSGKISAAKPKSIVQNTGANTNKAPTYIRYTPGQGAGDGHNSGAKQRIIRMVDAPVDPMEPPQFKHKKIPKGPGSPPAPVLHSPPRKLTAKEQAEWVIPPSISNWKNTKGYTIPLDKRLAADGRGLQEVTINDNFAKFAEALYAADRHAREEVKQRNLMQQKLAQKQKEAEEDKLRNLAQKAREERAGLTSAASSSSKPPVPSDRPTAASMNIDYASSSGSDSEEESEEEKEDEQKVREREELRRERQKQRERELRMSKMGTEARAKQLARDQGRDISEKIALGLAKPTMSKESMFDSRLFNQSEGISSGFRGGDDEAYNLYDKGLFTGASSSIYRPKMGADNDSYANAEQLEEAMNQDKFDLGGRGFKGTDSGKDVRGSGPVEFEKEQVTAQKKKPEGDVFGLDTFLNKAKKGKRGNDDDIEDEDRKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7ULZ6</accession>
    <name>A0A8H7ULZ6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RuvB-like helicase</fullName>
            <ecNumber evidence="15">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">INT43_006710</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="15"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7ULZ6"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="65"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2183699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="457" mass="50191" checksum="7527F843625697A0" modified="2022-01-19" version="1">MASMRIDQVKNTTREQRIAAHTHIKGLGLREDGSAEPIAAGFVGQENAREASGVAVELIRSKKMAGRALLLAGAPGTGKTALALAVSQELGPKVPFCPMVGSEVYSAEIKKTEVLMENFRRAIGLRIKETKEVYEGEVTELTPEETENPLGGYGKTISHVIIGLKTVKGTKQLKLDPSIFESIQKEKVTVGDVIYVESNTGAVKRVGRSDAYATEFDLEAEEYVPLPKGDVHKKKEIIQDVTLHDLDVANAKPQGGQDIMSMMGQMLKPKKTEITDKLRKEINKVVNKYIDQGIAELVPGVLFIDEVHMLDIECFTYLNRALESSLAPIVIFATNRGMCTIRGTEDIVAPHGIPIDLLDRLLIIRTLPYTIDEIKVIVRIRAKIEGLTVDDEAADYIAENGIKTSLRYAIQLLTPASILASINGRESITLDDVNEVDDLFLDAKQSAKNLVDKNYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UM93</accession>
    <name>A0A8H7UM93_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UM93"/>
    <dbReference type="OrthoDB" id="250548at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019351">
        <property type="entry name" value="DUF2039"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22876:SF5">
        <property type="entry name" value="CHROMOSOME 9 OPEN READING FRAME 85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22876">
        <property type="entry name" value="ZGC:101016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10217">
        <property type="entry name" value="DUF2039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2184973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="189" mass="22049" checksum="A60DE29F2BA6B9BA" modified="2022-01-19" version="1">MSVYEKKATQRKGNNKKGAQAHQNQTAWKPNKNSKISRTINALPVYGLCNRCTDVILWRKKYKKYKPLTAPKKCTSCQQKSIKEAYHVLCDNCASNKKVCAKCLESKDIVTEKSEIKTDRDLQKEEQELERLLSRMTLRQRRSYLRKLERGEDLSHIKAEDFDDEDFEFDIGSDDDSDDEDEEDEDSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UN58</accession>
    <name>A0A8H7UN58_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTI2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UN58"/>
    <dbReference type="OrthoDB" id="6417021at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110078">
        <property type="term" value="C:TTT Hsp90 cochaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018870">
        <property type="entry name" value="Tti2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226:SF2">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10521">
        <property type="entry name" value="Tti2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="327" mass="37144" checksum="B3A69284D70689A9" modified="2022-01-19" version="1">MEVLVSMHSQMSTSNWTTIVDQCKWPCCQEFHTTEEKQSHVLQQHLGKIVDEQIRPAYQKHKHPALNKPLPGARFTDNSLDLAFHENQNWKERNVLGYASIDVLEWVVQLASPPQLDQTYPMLAPAILITVDDFDADYKVRGVHLIQCLITKVQSNLLITSGLGKVFLETLFHCLTYIRADAARPDLVQASYQSCRDLISLLADVESKSRIHMCERLLTEGILLSGTAELWEIRRIGIEQIPFICNELGIMTVQYVKSILVLICDILESSHASSEMKIAAGKVLTPVMQSCRPRSVPDSYTHLQKLLLSNNGITEYRFIEVRSLSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UNZ7</accession>
    <name>A0A8H7UNZ7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_002204</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UNZ7"/>
    <dbReference type="OrthoDB" id="77201at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034485886" description="glucan endo-1,3-beta-D-glucosidase" evidence="15">
        <location>
            <begin position="23"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2185769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="301" mass="33195" checksum="D51F0E7BA066267B" modified="2022-01-19" version="1">MKITSLLASAAAFLTLSVSVAAAGTRKSLQNDYAFLGFTYSSCKNAADTLADFKLMKSLGARHVRMYGSCGNTWLSTLLDAAGATDIGVLAMIWYGYDDTSIGNEPALENSIVNIIKTHQYGNNVVAIAVGNEELYDQTVTADQLIQAMARVRTKLQGYNVPVSTSELTCCLPSNVVQAGDMTMTNILPYFATDATQGKHAWKDVLPDVNKYRAINTTKKFLITETYWAWKLNDWKPNSPDCSTSLQDMSDYWALLQHHCSDFKSWNAGYFAYCFNEDCMTGYGITDGTKPRISWTPALTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCK8</accession>
    <name>A0A8H7PCK8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Presenilin</fullName>
            <ecNumber evidence="15">3.4.23.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_009065</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Requires the other members of the gamma-secretase complex to have a protease activity.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer, nicastrin, aph1 and pen2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Endoplasmic reticulum membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Golgi apparatus membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The PAL motif is required for normal active site conformation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the peptidase A22A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.-" evidence="15"/>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCK8"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044351">
        <property type="term" value="P:macropinocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.100:FF:000003">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.100">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001108">
        <property type="entry name" value="Peptidase_A22A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042524">
        <property type="entry name" value="Presenilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202">
        <property type="entry name" value="PRESENILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202:SF13">
        <property type="entry name" value="PRESENILIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01080">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01072">
        <property type="entry name" value="PRESENILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="564"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="594"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="17">
        <location>
            <begin position="77"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="425"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="499"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="425"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="499"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2171404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="628" mass="68901" checksum="3E793445C5BA92F1" modified="2022-01-19" version="1">MLEHVVGDRNVHDGDTWQNKNSTTAPQLCISSGSTFISNTDRKDLHLFEIMTTALSSTQDEIELQNSDPVPPGDSQCNVCQKPAAFMCSSCGLNGPRYCSTECQSQGWREGHYRLCQGNAQARANAASRASNNTPEPAAAAAQGSIPMVEIRNNETSTEQDEQQEFADELRFYIKQIYLVIQPVVICIILSIFWVKVAFSGTSDYTPVRPSYSIGTSPTTTSGGSDSSSSSAISSLTTALVIVGQIILVTLVIVFLFRRGWIKILIGFFMIVVVGLLGFMSYLLILNLIEVFYIPLDYPTMIFALWNFAVVGLISVFWKSPLWLQQAYLTIMSSLMAFSLTGLEQWTTWMLLGLLAIWDLIAVLCPFGPLRLLIESSRTQQREVPALLYSVNAVWFMASMENHFRISQSFLPKEDHEIGTNWIYQDTGQPTTDAGTSQAQAVTTVETVRSNSPQPLGNNERDRVWNDESGPQGAVIEGHQARDGFTRLRGESVNTFATGQEQNVTTLSAATPNPNRSSHASASAGESETVPADEEDAERSGLKLGLGDFVFYSVLIARAAMYDWITTVCCTVAVLMGLTATIFLLVLWKKALPALPISIAFGIMFYFVAKAVLVPYVGTVCVFGMVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCX5</accession>
    <name>A0A8H7PCX5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_008339</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCX5"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2171613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="898" mass="101351" checksum="FBC2A9423FE21A84" modified="2022-01-19" version="1">MAYMLCQVTQVRDSHTRQNQELIRANTEYLRRIHTLEKEIETLQCENIHLRSLLAINNTKKEDAEPAKTSPSTATKSQIRKPGKAECRRRVIAWLSPASTSRIQVCTQFSTSSPAESVTLTYTRPIGFAWNVATVAKSYYTARFDNAHMSTSSPISKRHASTNASGTILNADGVDAQMQACLHTKDFHTALDLIEQAQALGVVKPEHYQQLFAIETAAKADLTSLARIAHWFTSTKGQLPANTKEEIDVWKSVMKACFKLARSHLHSDLDNLLKTFIKVVNIDNLRDADVWGIVLRGHGILKQEKVIDELILKIPDNVDYLEAASLAYSSAEAWEESDVHLQQVLRDHTPDAAFFGTLARTAAFCGDVDRVKTIANEYATHMSFDRDLLLAYKTKLMQYWQQQGSRSRYSGRNNKSKRNHGIDGMKAESEELISVMLSDGYPLDTTTTNIILDYLTLGNRMGSADFPMSRARDVVEKTMPAKGVTPNFQTYFLLLRGYAKTREFDSTEKSRLDMCLEVFYQMEHAGFNSHAHAKFQCLFEACLPHSQWYNFDNFRTKGLLAPTIQSSIVHHKTPVVDPRIFDIEKIMLESNVHHDRITIKTLLTCFGVSGQFSAMWRRWKELEYAGVRRDTGLYERVFALAALDPEQAQYALSVVRHQLTDEIPQNKMTLGLYQTIIDCCIAAQDATSALTVLHSAGAVDLPSVDAVEGNKEKKLWNMQLRAQLGIRSLTGPIDTHLKEAMALAVHPTSDIWLMLMSHAIDSEFDLQNAQRVFNGFTMSRFEQTGKVPLPAHTKSPVIPFPSAPYSETDVLMIDMFLATLLKSQNIPVIRDVLETYVEQSPSLWLSRDSVKGFVDLAKKEKSRDDVKWLVDNVLPKVENQSSKFKRWASKLQSVVNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDC7</accession>
    <name>A0A8H7PDC7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDC7"/>
    <dbReference type="OrthoDB" id="2404785at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="392" mass="44280" checksum="ED6C0710081B9C0C" modified="2022-01-19" version="1">MSSAGPAYEIRFRDDEVGTFIHVQIIDLTRNGSGAESRRLPNVYRQSYLLRRESVMLSSSTTPTSNATAEYHEEDRLQQGVTDHDVEVSSLAVRDKSQATSSTRRTNASTASQPIPINSAASSSSTRQLAKSAPLNRNVYDDNEQLDTNFSWTTGRNNKNLDVIPTVARRLAEEEAMDHLRRQEGEEAMRKAMERKAKIAAARQNANKSSPDLRPQGSSKSEQTTHQRNSQHQPKDRIRMASVDYVKDTSAVDQSKNQSTAFEQRQAQDNNTRDIRKEVEEYLKGTDLRKGDNRLDSQPNVYPYNSYERMDANMKQPLKGDVANYQMKEQHLAYNGPQKSTKMKYDREYELSRLQEGNVHANTSISAQMNSETQDLGHDSSNDKKGCCCIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDS5</accession>
    <name>A0A8H7PDS5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_001523</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDS5"/>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040746">
        <property type="entry name" value="THO1_MOS11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18592">
        <property type="entry name" value="Tho1_MOS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="68"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2172046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="271" mass="29566" checksum="B066B2668B40D533" modified="2022-01-19" version="1">MSEKYSKLKVKELQELLQKHSLPHSGKKDELIERLVKHDEKKMDDLALEEELGNLDEFDEAKLEELAQDPEFKAMQQQAADSEKQTTAATAAEPAAVAPATSDEKTQPAEPVEQVKPGSNFKFTPVSFDKTADSETSSAPAKSEAERRLERAKRFGVPVQDTVKKELRAQKFGDSTSPSAKAPASAAPVAAAAAAPSPTRPKASPVDDETLRKRAERFGLPTKTASQAAKPANGKKESPKAQLSPEEEEKKRKRAERFGKPAEPVEKKAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEC3</accession>
    <name>A0A8H7PEC3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Iron hydrogenase small subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_004909</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEC3"/>
    <dbReference type="OrthoDB" id="10253113at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003149">
        <property type="entry name" value="Fe_hydrogenase_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02256">
        <property type="entry name" value="Fe_hyd_SSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00902">
        <property type="entry name" value="Fe_hyd_SSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase small subunit" evidence="4">
        <location>
            <begin position="470"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2172367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="537" mass="59996" checksum="87C496D8D869BB8A" modified="2022-01-19" version="1">MAFSSALVLTDLNDYISPSQACIKPVEVQKKENEEQTSIKVNEAGNYYEVSVDGTEEKLESASISLNDCLACSGCITSAESVLITMQSQEELYKILKTNAEAQAAGRTDDIITIVISMSPQTRASLAAKYDISPMQAHAKLTHFFKHHLGAHHFFDTSFSRDFSLVESAREFVERYRTYMQKGGEQIEAARLEQEEKEQAEENTNGKTRQRRRRARPGDGDANGTASLEEMPMLASACPGWICYAEKTHGFILPHISAAKSPQQIMGSIVKDFYAKQLGLRPNQIYHISVMPCYDKKLEASRPDFFDEEFQTRDVDCVLTTIEVDKMFSEQNVDFKTLPEAPLDELFNKIGKSSSFQNPTLYGSSGSPSGGYLEYILATAARELFGVQDVSNNLYVQTVKNADFTEYTLKSSEGKPLLRFASAYGFRNIQNVVRKVKNNKCAYHFVEVMACPGGCINGGGQIPVPAEETNLTAKDWISHVDNIYRSVEGVRPEENEAVKALYSEWIGQETSDNAKRLLRTQYHAVTQNLTNPLATVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PED3</accession>
    <name>A0A8H7PED3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioredoxin-dependent peroxiredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_004890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PED3"/>
    <dbReference type="OrthoDB" id="61390at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000020">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF16">
        <property type="entry name" value="PEROXIREDOXIN-5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="326"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="7">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00079296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2172348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="492" mass="54573" checksum="E41474502691FA58" modified="2022-01-19" version="1" fragment="single">EIRLLCQELLGLGPGKSAIGSEHDMYGLQHTLYNVQLVPETFWFNMGYWDSDTQSFAQACQLLVRKVMSQMGSHQQKGHILGNATSYVGFGCGDSCFMLAEEYNYQVTGITIESSQFEIAQRRLQDQYGHFDKSIQLIKGSATDLTTIFKNIPPFDNIIAIDCAYHFDTRWTFLSQCVRLLAPSGRIGLFDVAIQPNAFSHPYKRSIFDKICSLGNIPVANLVDHEEYEARLRQIGYTDIQIIRIDVDTVYGGLSRFLKRQGTAYLNAGLDLGLGNHVRFFVVAYIMDLLCWCKWIEPIIITAKALSEMVWLVCSSFIHYNCHKMIQIGDTIPDVPLSYVPYDPKEDLKACTRPIQFKIHDQLKGKKAVIFAIPGPFTPTCSEEHVPGFIDNADKLKAKGVSHVICVSVVDGFVMNAFGKVTGSKDKVIMAGDGSAKFCSALGLTQDLTDKGMGVRSKRFAIVVDDLVVKYVGVEPAPGTTVSGAEAVLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEX3</accession>
    <name>A0A8H7PEX3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine synthase</fullName>
            <ecNumber evidence="3">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteine synthase-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_001528</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEX3"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000096">
        <property type="entry name" value="Related to cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="12">
        <location>
            <begin position="68"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00078545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2172051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="415" mass="45654" checksum="5005F0B56E41EA59" modified="2022-01-19" version="1">MSAHNTNHQWLWGILVGSVLTASSIKVYNQFFNEKHPAHRPRRDSLDESHLCPPGNVRGMEIVDGVDGLIGNTPLMRIRSLSEATGCTILFLNPGGSAKDRVALNIIKTAEDEGILHPDNGSTVFEGTVGSTGISIAMIARAKGYNAWIVMPDDQAKEKYQLLEKLSATVEKVRPVSIIDKKQFVNLARTRAQEFGKEDSNTTGAIGYFADQFENKANYDIHYKTTGPEIYRQTGGKIDAIVLGAGTGGTLSGISTYLKSLIPRLKVYLVDPPGSGLYHKVKHGILYSPFEAEGTRRRHQVDTVVEGIGINRLTQNFDLGFENIDNAYRATDEEAVKMARYLVREDGLFIGSSSAVNCVGAVRVARELGPGHVIVTLLNDSGQRHLTKFWSDDYLRENGIAYELSKDDTVDTIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PF13</accession>
    <name>A0A8H7PF13_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_000040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PF13"/>
    <dbReference type="OrthoDB" id="2017782at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052645">
        <property type="entry name" value="Pumilio_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093:SF1">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="376"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="471"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="617"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="684"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="761"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2172693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1061" mass="116239" checksum="DB711063BC1A666A" modified="2022-01-19" version="1">MLEAAAEENESGFKSKGLFASSQKTSALQFLKRSVENAKSSKSHLPIYPISTASLESVPMYEYDDIDAGSNAAARRQRADTMPSLSTEFPYTDRQMCLLPTSTPSRNRSGSATLPPADTSPDFHSAIFKSPAWVNHGKGPHESDHMYKEDYDDSIVSTMATLGLDDERSGAGSASIHRSGSSPALVNRSQTMHHHSLFPPVEPSSIHSTTNLTTGVTSHNRSMSGSSNHSLSETSDAYYLKSASLRTSPSAVPHYLAQAGGSRPRAISLGMAEKQAFEEEHNFVPSMRFQRHPVWQAEASRMQARRQHGLRNSCSTADLRNMLEPSSSNFPMFTPSPKSSDHGIYDDWEQYLSSDHPQGMGLSSSPSSSQTQQPTRSLWLGNIDASLTVNDLTRLFGIYGPIESARILLDKECAFVNFMRLEDALAAKDDLVTKLGCRIAGHTVKVGFGKPEAIAQMGCNDIGSNSQGPTRALWIGNLPNGTTSGALMAAFSPFGAIESARVLTHKNCGFVNFELQEDAMLAKKSLQNKDIPGLGPAARIGYAKVPGNGSSTTGLESDMAPNPTSRVTQQQVQVPQIAMSQTNNTSMEAYQNRMMMLMMSEMAGGSASTLTQAAVLERQYIMKEFGEDLNDGPQFETAPASATYYSSIPTEFDFANTRKIDPNRLREIRKKLDGGNFTYEDIEEIAAECIDDIVELCTDYLGNTVVQRLFEYCSDATKTRMLSEIAPYLGTVGIHKNGTWAAQKIVDTASTPQQIHLVCSHLRPYIPALLLDQFGNYVVQCCLGLGPDLNQFIFDAIVDKCWDIAQGRFGARAMRATLESPHKYVASAIVQNAILLATNPNGALLLTWLLDTSNLKDRYGILVPRVIPHLAHLCTHKLASLTVLKLINQRQEPRARDEIIQHLFFSDSDTVVDEVLLDQVHGVALVQKILSTSYIELQERQHIAERCKQCLSKLKVQHVQGYKRLVEEINMVMGDSTGAGFAGVPGFVAPFALTPEFAAALQAKYLAVQQQQSSTIPEKMESNSPYANIDPNVLKLMMNNILQQAASHSPENEQPDKADRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PF36</accession>
    <name>A0A8H7PF36_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_000129</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18659">
        <property type="entry name" value="CD2_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056342">
        <property type="entry name" value="HTH_CHD6-9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF11">
        <property type="entry name" value="KISMET, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23078">
        <property type="entry name" value="HTH_CHD6-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Chromo" evidence="8">
        <location>
            <begin position="387"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="491"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="803"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="150"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1076"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1312"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1391"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1481"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1715"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1766"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1322"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1485"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1538"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1558"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1578"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1590"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1622"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1815"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1833"/>
            <end position="1844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2172782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1860" mass="213468" checksum="A260627FE1D836DD" modified="2022-01-19" version="1">MAQQRDMYNQYMPQNAYQPNPGYAQQAQQQAPTEPMSSPQQQQMHRGYGPNPSYRPSPPFAQALPPTSSAGGYPQHIQQLQQMQQMGYAQPQNMQFHQMNMPPQGYPPNMAFQQSAMHPRPAMPQMSSQMQQQMHQMQHQQRPVYQGMYGMPQGMVPPQQQQQQQQMMRQMPPQMQQQMNRFGPPGGQPGQPGQPGQPNQQNMMQWKMMSQNPMQHAQYQQHQPQAPAPPQKVRQSSRKTKKRVVYDEPSSDEDEELELPSEESEDEQSDFDDSDTPKSKKKQKTKKDSTAVEDIEEAVTIPMGTKEFEKILHYRKNPENGKEELLVKYKARIHPTLARKLNMSYHHVEWLPITQVESAHLGKHRVKKFMSKWHADGEKGEDYQEYLKIDRIIDEGEINDPETDELKVYYLVKWNNTFYDGSTWESEDDVEKIDESKIDEFHSRRTMPEQKKANPPARPYINQYFKYDRSPRFKYQNELRSYQLEGLNWLRFCYYSFRSCILADEMGLGKTVQSVALLNDIYCGLNIRGPFLVVAPLSTIPHWERAFKAWTDLNVIDYRGSQLARALVHDTEFFYKDAEGNTIPTKTKFDVLITTYEMASAGAPHLREIPWQAAVFDEAHRLKNKQSKVLEILKTFTIYHKLLLTGTPLQNNLDELFSLLHFMQPEIYSDERLFFHEYGSLQTAAQVEKLQLMLKPIMLRRFKEDVEKSIPVKEETVIEVELTNPQKRYYRAILERNFTFLKKGTRTNKELPHLRNIMMQLRKCCIHPYLLEGAEEVVTSESNAKTAEAQFKCLIEASGKLVLIDKLLKKLKDGNHKVLIFSQFTTCLDILADYLRGRNYNYERIDGGVPSEQRQAGIDRFSTMPIDESFVFLLCTRAGGVGINLTAADTVIIFDSDWNPQNDLQAQARCHRIGQTKPVQIYRLVCRNTYEKDMFDRAGLKLGLDKAVMRRMESQSSSVNEDEGGISKNELNKKEIEDLLKKGAYGAMLDDESSAQFCAEDIDQILERRTTVIRHEGNEQGSMFSKATFSSSDGATVELDDPDFWEKWAAKAQIDATETPDENELIVYQPRRRRQVQRFGSRPADGSVSSNDEGDSDAYVDDKEKGRRKRDGIRPWSLSEKTKYERKLMIYGYGRWKSMKQHFPRRTERDLKAVTRAMMRLILPTIERNTEEDYRLIQDIEGLLDGDVDDEPRNKAIPFTGATKAQIAEYRTFLLEAPQDYIDHVTKKGRNIVLRIQMLHVIRDKIVPHEWDEAKKLEIPKVTGNPPATWWGEKEDRDLLLGICRYGYQQYYAMRSDPEFCFYGRKYDDSQAGLDDEDDKQESDGENEKAGNADDNGSAFIWPSKADLGMRLRRIIAAFLREKAIVNRKESRMQKHMEKEKAKEAARERTKLARQRKKEDRLAEKQEAKWRETSKRWSKKSKQDFLRTLMSFGVETVAGDPTVIWDRFKELSGLEKKTDESLDLHLQDVISICEDVVKRHNEGANGTGNGNATGTAGGKGADSSLMDDHSRDSSMDPSAAPSKAISESGDFNADTEDKDVSSVKEEAPTTMDNLASNHVDDLKEEPAATKAESVSTAKTEDDADLKLDQDLEDKNDDDNDNDNDNDNDNDNDDGEGEGDGDGEGHDSDMIPYDRARRVLKRLEQMKTIRESVIVHPDLDELLSRARKTSGLPGWWQVPEHDKAFLQGICKHGVNRSELIVADEDLPFNHIKKQIEQRSENGEAQDGEAEGSTQENEFLWPRDLVIARRIESLCELVLKPKPLSKRGALNRKRKAGQSEAKDNGVSKPSGLKLTLKVNKKQDYASEDESMATYSSDEGDDTDDMLEQASERIQNRSQTSQSVSELDTNEALPSKKPRLEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PF90</accession>
    <name>A0A8H7PF90_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptide hydrolase</fullName>
            <ecNumber evidence="14">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">INT43_000183</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="14"/>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PF90"/>
    <dbReference type="OrthoDB" id="76293at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000008">
        <property type="entry name" value="Endoplasmic reticulum metallopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF22">
        <property type="entry name" value="ENDOPLASMIC RETICULUM METALLOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 14" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="428"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="508"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="573"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="16">
        <location>
            <begin position="171"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2172833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="925" mass="102092" checksum="B6FDAC63E23BAC11" modified="2022-01-19" version="1">MAPKRSASNFDKKYTNGGSSFDSAPVRGMAPLRSYLLLGTYLIAAILLGSSLHYQLPQPKTHRGISPLVDAGEFSEYNAIETLTYLGDTLGYRIVGTIEEAQSADYLLQKIESYKQFSRGIPDAPKFDVWVQHQNGSHRFDIMDHMVLKMYTNVTNIIVRLSCPETPANESRDCDQNAVLLNAHFDTTLGSPGASDDGSGISVMLEIIRIMSQKSWDGYKNSMVFLFNGAEESLQDASHAFITMHEIKDSIRAVVNVDSCGTTGREILFQANSREMIDAYKQAPYPHGTVMANDVFSTGLILSDTDFRQFVEYGDNLIGIDMALYKNSYLYHTHLDTPKHLQPGSIQHLGENVLAIVDYLAKNTTLTGLERTNQVVYFDFYGKIFLVYSWDTAFVVQMSTVAATACFFAYILYRSTSTSPYRSIGQTLLAYFVSTGSVIVGFVSAVAAPNIVAIILTSGLVNRPMSWFKNEAYGGLIFGPAALVAIFSTQYVSKLLPIAGHPDPEHAGFVSVLMAFTVVTMITTLTGVASSYIFFVFNLFLLLAAVINEAVLAPRSTKSVYKNGIRVGRLSHWTYMISVFPLSFIYIDYVFSLIDIFVPLTGRMGIDTPVDNIVAFIFGMVTFMLTTPFQAHAHKFGKKILAKVIGLLFVFQLAVITSVIYSGASYGGWAFPYDELHPKRLFVQNLKNITSGESSIIVAEADKAAYTLPIIHKLEQAFGVPAEVRGGSVHAAEWDSVYPFSAFLGGYRFDTNEYIKSHTSNSSLAASNEPIGFQLVGKIPSVKSFDSVYDHSTGIRSFSIIAIAPTYTWTVISFDAHVLSWSIGDTEPLNQTSHYVVRHVGGYGSDGWRLDLKVLVPEEVRAQGEEAARAWTMRAEFTALEKEGFAHRGEERLVGGVGMLGEVQKLLPIWTSTTWFGSVVGVWDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFR6</accession>
    <name>A0A8H7PFR6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_004505</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFR6"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="130"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="172"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="221"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="256"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="318"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="348"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2173132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="385" mass="42407" checksum="F29AC4DBCA826F72" modified="2022-01-19" version="1">MSADKRKDPPSPPTQNGVVIKRQKQENKEESSSAVALSSSSATGKNLVVGTIKRTSGLQAPVMLLNGHQGDVYTCEFDPSGQHIASGSFDRQICKYAWVGRDDTYHYLNTNRHEPVLWNTYGDCVNYGMMKGHTNAILELHWAKDAKQIYTCSADQTLGIWDVETGERVRKWKGHSLVVNSCGVSRNTPELVVSGSDDGCIKLWDAREKNAVETFQDDFQVTAACFSDAGDMVFTGGIDNVIKAWDLRKKAVAYTLSGHADTITGIKLSPDGSYLLSNSMDNTTRMWDVKPFAPADRGVKTFEGAPHGYEKNLIRPCWSPDGNQIASGSSDRSVVIWEVSSRKILYKLPGHKGCVNDVDWHPKEPIIVSGSTDKSLYLGEVKPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PG02</accession>
    <name>A0A8H7PG02_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation initiation factor RLI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-binding cassette sub-family E member RLI1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_004582</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the multifactor complex (MFC) involved in translation initiation. Required for the binding of MFC to the 40S ribosome. Required for the processing and nuclear export of the 60S and 40S ribosomal subunits.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PG02"/>
    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03236">
        <property type="entry name" value="ABC_RNaseL_inhibitor_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000144">
        <property type="entry name" value="ATP-binding cassette sub-family E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000152">
        <property type="entry name" value="ATP-binding cassette, sub-family E, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034348">
        <property type="entry name" value="RLI_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="70"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="342"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00067238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00082546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2173208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="599" mass="67296" checksum="A2762737F1D20BBD" modified="2022-01-19" version="1">MSDRLTRIAIVSSDKCKPKKCRQECKKSCPVVRMGKLCIEVDATSKIAFISEDLCIGCGICPKKCPFGAIHIINLPTNLEKEVTHRYSANSFKLHRLPSPRPGQVLGLVGTNGIGKSTALKILAGKMKPNLGNFDNPPDWQDILKYFRGSELQNYFTKILEDNLKAIIKPQYVDHIPKAVSGKVGALLDAKLERNNREDIIAALDLQDVLQREVNQLSGGELQRFAIGVVCVQQADIYMFDEPSSYLDVKQRLKAARAIRALISSQTYVIVVEHDLSVLDYLSDFICVLYGMPSVYGVVTLPFSVREGINIFLDGKVPTENLRFREESLTFKISEQADEATVDKNRQYKYPTMKKVLGDFKLTVHGGEFTDAEIIVMLGQNGTGKTTFIRLLAGLMKADGDEQVPELNVSYKPQKIAPKFQGTVRMLFIKKIKAAFMNPQFQTDVVKPLNIESIIDQEVTHLSGGELQRVAIVLCLGQPADIYLIDEPSAYLDSEQRIIAAKVIKRYIIHFKRTAFIVEHDFIMATYLADRVVVYEGIPSVDAVANTPQSLLTGMNKFLASLEITFRRDPTNYRPRINKMDSQLDQEQKLSGNYFFLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHU6</accession>
    <name>A0A8H7PHU6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHU6"/>
    <dbReference type="OrthoDB" id="2309881at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2174243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="80" mass="8902" checksum="B25116A0CACFC081" modified="2022-01-19" version="1">MCFEATSSSFITQCPATCELCSHWLPNHSVSAFFTIPYRGSNSCPRKGVHPSQWSLAPSVDISELDDYEDLLDNSSDEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHZ9</accession>
    <name>A0A8H7PHZ9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_004341</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHZ9"/>
    <dbReference type="OrthoDB" id="1306014at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215:SF0">
        <property type="entry name" value="BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215">
        <property type="entry name" value="ZINC FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="273"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="172"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2174318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="351" mass="37305" checksum="AAF6B332F297BA28" modified="2022-01-19" version="1">MGKKKSKKQMRPWCWYCEKDFDDDKVLVTHQRAKHFKCDVCNKKLTTAGGMAVHAMQVHKVEITKVPNALPGRETLEIEIFGMEGIPPEDLAAHEQAMSGGNPAKRFKAGGTSEYTALTPEQIQAQIAAHKAGGMQPAAASPGYPPPASPAVAPPVTSAYPPQYSQYYQQQQPPPSHYPPRPPPPMGFRPPPYGPPPPGYGGPPPQHWSPAGAAYPPPPGMSPGYPPTPNAAMSPNAPIRPPITPGYGTPPSAGAPPPASAVMSGYPGAAPYGSPAHNQPYDPNAGQTAVPVPGNYEAPLPQPSVPSVPQTIAPGGKQKPGKTQLIYSDNEISPEEYRASLDKYRFEQTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIG4</accession>
    <name>A0A8H7PIG4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin MVP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_004189</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for vacuolar protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIG4"/>
    <dbReference type="OrthoDB" id="2384925at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06866">
        <property type="entry name" value="PX_SNX8_Mvp1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028662">
        <property type="entry name" value="SNX8/Mvp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035704">
        <property type="entry name" value="SNX8/Mvp1_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045734">
        <property type="entry name" value="Snx8_BAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554:SF1">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19566">
        <property type="entry name" value="Snx8_BAR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="73"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2174169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="440" mass="50944" checksum="A220FC548B1735CA" modified="2022-01-19" version="1">MPLDEEDPWGDTAVREPATNTRVLTPTGAYSNGKASNQETAFDPPLPHFDSSESLDDNSEADNEDLSHINIDKADTVTVQIAPEKEGYIFKHVMYIVQNSERSSRVLRRYNDFAWLYDAITRRYPTRMIPTLPPKNLGGRTDAFLEKRRKGLSRFLNSLLRHPVLSKDELVHVFFTEPSELGEWKKQNTPSLEEDFARLQMDNASNEATSSWNERFEKAQSRNELAVKAYTEMCFTMDRIAKRQANQAKDYTRYGASLSSLSELENWCYTEACQRRCNQVRLDSEQVAKHLQKARVKMQNNAEALYADTLEQLKRQRDLCMSFKDLCLRKPKVWGNTLEGLEKRLKANIIKVNQNRGIPGMEAEVEKLDNAIEQDKHALNLEQKRRAYIAKCIEEEIRYLQEQESYAIILHRNFTQLQAESEQNLLNIWHQLENKLSGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIV8</accession>
    <name>A0A8H7PIV8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_005874</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIV8"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056521">
        <property type="entry name" value="MARCHF6-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23113">
        <property type="entry name" value="MARCHF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033988673" description="RING-type E3 ubiquitin transferase" evidence="12">
        <location>
            <begin position="28"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="504"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="709"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="751"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="804"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="846"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="891"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="935"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase MARCHF6-like C-terminal" evidence="13">
        <location>
            <begin position="791"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="35"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2174812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="989" mass="110590" checksum="588FE8A7333F4C63" modified="2022-01-19" version="1" fragment="single">MQGQLITFVVILAFVALFLLREWVVQNTPPDLPVNDVGEEAPAGAAPIPPLAQLDRPRLFQDLSSDESESDEDNEEEAQNRAVRNAQRNAASAEGVNGRANAVNIGWQAPELNAAADRAQPPVEVNAARLALQARQMQAIQQGNDNNDDEFEFENAVDDLDGVLEAVGLRGNIVVLLQHTALMVVLIAGCLGSAVWTPYIVGKAFILIFPTVFVQLPIQLLRLFIDPIVDIALDVVLPFVLETFKSQSSHLQHLAETSPVVKSIIDGFQSLTWHSGGASNNADNGYQVWSVTGDKSFHDIAHLSWSQNATFVMPYWEKLVNTDYEQLLIAMRSQWYRFALEDSTTDRMACILIGYGVLVTIGSWYLARSRNAYGRTVGRALQQALRQQGAILKITFFIGIELMLFPLGCGMLLDFATLPLFPGSTVATRFAFWQSNPGIWTFFHWLLGTMFMFHFAVFVTLCREVVRPGVMWFIRNPNDPQFHPIKEILERPVMFQLRKIGVSALLYASLILFGIGTVVAAISHFGGTILPLRMSMENSSFSYHIDLIAAHVVIPTTMTRLKVKARFKTLLQAWWKVVSKHLRLSSFMFDGRFAEEEGTHVRKTWKAFLLRRKAPIPDISDGEVSINSFSADGEVEFVKNGHLVRAPKHDGVPVVRGRRMLVPVDPETYAAIDETDRRLGHPASAGPGGEELNTVVVYVPPKFGRRVIYFLYLMWVSGAVLLCSATILPLIMGRYLFTFYLAKDHAMHDLYSYLLGLHVLLALSFTADFVVRKINAWQAHHFSMSWPGVYHTVMHALARVANTTYVMLAFGLVMPMLVGLFVELYFVLPLRRSTRQDITTNLLQDWSVGIVYMNLTYGFLSWLPENYWRRSLRQIFANGILEAEARQATKLFLGPVILGGLLAIIIPALVAWAAIQIFAAPDNATVQNLIVRLAYPVACGLVILYRTASLSIVAIKAWVQSVRDEAYLVGRQLHNLPPPQRDTDSQDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJ67</accession>
    <name>A0A8H7PJ67_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_006019</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJ67"/>
    <dbReference type="OrthoDB" id="196650at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF31">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2174957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="389" mass="41837" checksum="3A86555EB6884500" modified="2022-01-19" version="1">MPDKWDLVLMGGLVGSMFSFLQFFVSPFIGSLSDRIGRRKTLLLTMIGNLVSTVLWTFASTFNIFLWARIVGGLSEGNVQLSIAIISDVTDETNRSKSLALVGIAFATAFTFGPPLGAYFTSFDLSTISPTLVKYGVYAFSSPALVALVLLTVEVAYIMAFLPETSNLHKGDSQKNESKKSTVGQPSMVSRNLSNLKTLNLIHALHLFIFSGMEFTLVFLTFDVFDYSNMQQGKLLGFIGIASSLIQGGYVRRKARTAGEKKMVLQGVIACVAALVMFALLAEMRSGTTLLFIGAFCFAITSGTVVSCLTSLASMQCSDDDPRLAKGHALGVFRSYGQLGRAIGPLVACTVYWAYGPVVCYSLGAICMSAVTATVVKCIPQTPKAHKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJW2</accession>
    <name>A0A8H7PJW2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_005921</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJW2"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="44"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2174859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="382" mass="42155" checksum="5E1942CFC76A5DEB" modified="2022-01-19" version="1">MSTNVVVIGAGVIGLTTALLLQRKGYRVTIVAKYVPGDMNIEYTSPYSGAHWRTMSPNDNPELQRKYYIYQNNDCKWLSETLHIDNDATAYGIFWNIAEQLPSNETGVMIIPALDCFNERNDETANPWWKSVVKDFRFAESHELYPGTVIGHCYQTVTINTPLYMTWLLKLFIKGGGQLKKDALSHVHGALRHCPDAQAIINCTGLQARYLGGVKDLKVFPTRGQVVVVNAPHIKKTLTQMIGDETTYVIPRSNGHVVLGGTRQANNFDGAIDQHTADSIIERTLKLLPELSHGKGKDGLEIVRHSAGLRPTREGGPRVENEITNTPGNKRLLITHCYGHGGFGVQSSWGAAKKAVDLVTHGLGSPESVMIDSIVNGLWSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PK53</accession>
    <name>A0A8H7PK53_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_001164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PK53"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2175517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="34003" checksum="FDAA632E878C3A8F" modified="2022-01-19" version="1">MADSLITQVSYPQAIPETDNRTTISNEDPLPTILNFNLRGRPFRIARDILISLPESLLIAMFPHGLAISPSDDSSSFASMEEPVYYVDYNPDCLEFVLRFLHSTNAEFADERSMREDILLASRALGDTEALSPIQYQLLTKQAVIVLREELEFYALPPKHFPGQHAYTINELKLQCGERLVQQKQIFTPLERNINKEGNMAEQHLIDMLCQSGYSRNDHWNHRALEPRRTCIMSMALSKLETESEQGYLPTAQKMLLFWKKPARKCWWEGSGVEVGRLAIRVWCRRTWTLELTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PK90</accession>
    <name>A0A8H7PK90_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucosidase II subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_001113</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PK90"/>
    <dbReference type="OrthoDB" id="3237269at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06603">
        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000039">
        <property type="entry name" value="Glucosidase, alpha neutral C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000023">
        <property type="entry name" value="neutral alpha-glucosidase AB isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033403">
        <property type="entry name" value="DUF5110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17137">
        <property type="entry name" value="DUF5110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034416311" description="Glucosidase II subunit alpha" evidence="11">
        <location>
            <begin position="23"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="13">
        <location>
            <begin position="86"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="12">
        <location>
            <begin position="381"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="15">
        <location>
            <begin position="717"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5110" evidence="14">
        <location>
            <begin position="823"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2175466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="939" mass="107092" checksum="A80C89B6DF638CCC" modified="2022-01-19" version="1">MPLRSWALACLAILSLFLLSEAVKKEDFKSCSQSAFCRRNRALADSASEQSNWQSPYTLVKDSIRFSNNFLTADVKNTATNNVLILELQVLVDNTVRVRMDEKSPLRQRYQDHAQFTLVDDAKPVKPFKSGKNTDGVVKITLDESGCRKVVVTPSPLRIDFLVNESPVVTLNDRGFFNFEHLRSKELHKPKMITQRNEDGSETEVEAEEEKDLWEETFRTWTDSKPNGPESIGMDISFHDFGHVYGIPEHASSLSLKETRGGEGAYTEPYRLYNTDVFEYEMDSPAALYGSIPFMLAHRKNESVGVFWMNPSETWIDIVKTAPESHATGVQKVFNMVKSTGQKKSTKTHWFSEAGVLDMFVFFGPSSKDVFRQYTKLTGKPAMPQSFAIAYHQCRWNYINQNDVREVDEQFDVHDIPYDVIWLDIEHNDGKRYFTWDEAKFPDPTKMQNELSQKGRKLVTIIDPHIKRDDDYYICKEAKDKNLFVKQPSGPDYEGWCWPGQSSWVDYTNPDARKWWADKFKLDNYKHSTEALYVWNDMNEPSVFNGPEITMPKDMVHHGGWEHRALHNVYGQIYHGSTADGLKERLAVQQRPFVLSRAFYAGSQRFGSIWTGDNMAQWDALQASMPMIMSVSVAGLPFAGADVGGFFNNPSHELLVRWYQAGAFQPFFRAHAHIDTKRREPWLAGEPYTDIIRNVVRERYALLPYWYNLFQEAHENGTPIMRPLVVEYPEDEAVFAMDDQFLVGGGILVKPVTEEGATQTNVYFPPSDIWYDLHTHDRVQGMASQVVPAPLDVVPAYYRGGHIVPRRERIRRSSHAMSLDPFTLVIALDANGEANGSLYLDDGKTFGYEKKEYLMAEFNFKHGVLTYSIQHKNPVFASSIASVRVERLVILGHPSASKAVATDGSGKRDLDVEKSKNGKLVVRDPAVLITENGWKIELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKA4</accession>
    <name>A0A8H7PKA4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative lipoate-protein ligase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_001249</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LplA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKA4"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000015">
        <property type="entry name" value="Sulfurtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00545">
        <property type="entry name" value="lipoyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="6">
        <location>
            <begin position="31"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="5">
        <location>
            <begin position="338"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="5">
        <location>
            <begin position="476"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2175602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="590" mass="65745" checksum="B8F9FA369302EDD4" modified="2022-01-19" version="1">MSGDNVECFISTHKDPFVNLAIEDHLFKTTDPEKYILYLWRNKPCVVVGRNQNPFKECNLRYMEEHGIPLVRRRSGGGTVYHDMGNSIYTIFMPRAAFSRDANAELVARALLQLDIPAYVNSRHDIAVDGFKVSGSAYKLTNRRAYHHGTMLIDTDIEMLRGALGGSRDKLVTKGVASVPSPVSNLRSYSYTIDHQQFCEAVIDEFLLAHNGSKPVKPVIFSQDDPSGLPEEVQKSKDELTSWDWIYGQTPEFTHDIEMDFTWGSVNAFIRSRHGHIIETEIQTSVTEAQEIMVISAIEQALQAFTTSSRPSSLISTSALAKDSSIKILDGSWHMPNANRDPYLEFVQKRIPGAQFFGIDDIKAKASDLPHMLPSKDTFAEAVGKLGISNNDHVVIYDSVGVVSACRVYWTFRVFGHENVSVLNGGLPKWISENRPLDTNKPIPADPAQYHVASVREELVRDYDTIIKNVKNVQRGEGGFLVADARSNARFTGEAPEPRPSLSSGHMPGSVSMPFQNLMSGTEFLDDEALKQKWLTQIPDLNQEIVTSCGSGITASVLYFTLERIGAQNISVYDGSWTEYAGRKESVIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLE2</accession>
    <name>A0A8H7PLE2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pinin/SDK/MemA protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_005528</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLE2"/>
    <dbReference type="OrthoDB" id="330772at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039853">
        <property type="entry name" value="Pinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707:SF0">
        <property type="entry name" value="PININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707">
        <property type="entry name" value="PINN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="9">
        <location>
            <begin position="61"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="174"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="80"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="185"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2176294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="279" mass="31463" checksum="D51713D5615961B2" modified="2022-01-19" version="1">MADPSPDLEQAKQTIVNSSIVVPASAEATSQRKRESEEQTETNGQNTDGPQKRPRLEMTQDGQRRGKRMFGVLMGTLNKFKTDTSTKSSAEKQRAEIDNKLKEKLERERKELAESIAKDKEEHIERQQEKKRRSKEEIAQKLALANAKHRLHLSRYIKTAIEPQLLYRPAKLSEAQAAQLQNQEESAKSELDEVVEKQKKARAESEMNEEEKANGTENRSDAMEDVEEGKDDISSEAPAAGHREASVEVQAIDDEDDSMDQRGEASSQNGDIVDYEVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLL8</accession>
    <name>A0A8H7PLL8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLL8"/>
    <dbReference type="OrthoDB" id="2431475at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132:SF1">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="300" mass="34115" checksum="B59F2B4654CE31FB" modified="2022-01-19" version="1">MSKKNQYGLSSAVSDLVRAAAGGDTTKVADEDLDKYIADLIHKEAMAKNKKYDQVGLKAYQPEPNPPANLPRMNKRFLLNVVKATDSHNQALIRATEEQAEENRRKMERERRYNDYRDRSPQDRSKRHRKSRSPSPSSSNTRKHRRHHCPSIHSKHTDHHSSASDMHSDASESVSSQPSEKPSSTFFKGRGNITAGGPSAMDKYFKDSYDPMKDTGDAVDDKGWVIEGERSEKKASKKKKSKKKSKSREHDDESKRQKSKKHKKHKSERTITIEPSANIGNLNDGIVYNKGVREWDMGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLP9</accession>
    <name>A0A8H7PLP9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">INT43_005450</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLP9"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16489">
        <property type="entry name" value="mRING-CH-C4HC2H_ZNRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051878">
        <property type="entry name" value="ZNRF_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="20">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="148"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG2176216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="199" mass="22136" checksum="0C7C94A3BBEBC293" modified="2022-01-19" version="1">MTCRRCGQVVCDRCSTHRANMARSQIVQDPSIPNWQQAQLATQPQRICDKCYTEMRPPTGSRSATAPPTQPQRIAGHGNGHIRRSTSSQSIMSECPVCGKRLSEVSLDKDVQEEHVQTCLNVGSPSVATVRYVSYKLPEQSPLIGQECLICFEEFEPGKSSGNTIARLTCLCSYHRPCIREWLEKGKGCPLHYQISIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLW8</accession>
    <name>A0A8H7PLW8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_001268</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLW8"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000050">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000011">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000005">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="11">
        <location>
            <begin position="68"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="230"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2175621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1138" mass="130828" checksum="7D98D6A91E5997B1" modified="2022-01-19" version="1" fragment="single">QDDTYSDLANEPMNDSAPPPDNDKIIQSLLRVATEHSYFALLITLILSTDEAIANKALPDLELEVEATTVSHWEIEDWRGLDKRVHGPEFEVAGYKWCVSFEKTKVLLFPHGNNQTEYTSVYLEFSDQAAQPQGWHVCAQFALLVSNPNDPTQYVIHNAQHRFTAEEADWGFTRFHEVRRLGSVDDNRTLPLVQDNATTITAVVRIMKDPTGVLWHSFVNYDSKKMTGFVGLKNQGATCYMNSLFQSLYCTNYFRKVVYQIPTENDDPTKSVALALQRVFYNLQYQDAPVGTTELTKSFGWDSLEAFNQHDVQEFNRVLQDNLEMKMKNTPADGAINKLFLGKMKSYIKCINVDYESSRVEDYYDIQLNVKGCKNLEESFKEYIVEETLEGDNKYMAEGYGLQDAKKGVIFESFPPVLHLQLKRFEFDMMRDMTVKINDRHEFPLEIDLEPYLSESADKSQPHKYILQGVLVHSGDLSGGHYFAFVRPTKDSNWLKFDDDRVTPATLKEVLEENYGGEPQGANALNTRPNLRTIKRFTNAYMLVYMRESMMDEILSDVTTNDIPPHLKRRLDEERVAMEQKRKERLEMHLYMKTCIITDETFSKYQGFDLASFDEKTGDTPAYLSYRTRKDDTLESFKAALCENLDIPFQHLRLWILVNRQNRTVRPDTPILESDYQLTMEQIREKTQPSQPNLRLYLEVADHFENGQAIFQAPPSSRSPTILVFIKLFDAATQSVHGLGHLYVDKNGRVGDIIPTLNAMAGFEKDTQLMLFEEIKPTMIDPMDVRLTFVRAEIQDGDIICIQKHISEENAQQLRSQHQYPIVPEYLDYLLKRVTIQFKPRFGTGTGGQFDLTLSRSMLYDVVATKVGEKLNASPQNIRFTAPGVSGTPKTVIRHLPNSTLMEMIQPSMYNGVNVPTLFYEVLDIPLSELETKKQVKITVLTPTLLEEKMYDMVLPKDNKISDLLQELERKGVKFESDSGTRLPRIFEAVQNKFIRELDMNETLSALTDSAYCTLYAEEIPEEETTATDDDFFVYVFHYQKETSRTHGVPFKFLVKKDEPFSQTKLRLQRRTGMDDKDWARVKFTIASSYSATPIDDDDFKLSDHHFAKEEHLGLDHIDKTGKASRVAGTERSIFIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PM73</accession>
    <name>A0A8H7PM73_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PRP1 splicing factor N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_005539</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PM73"/>
    <dbReference type="OrthoDB" id="440128at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000649">
        <property type="entry name" value="mRNA splicing factor (Prp1/Zer1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000384">
        <property type="entry name" value="Probable pre-mRNA splicing factor prp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001362">
        <property type="entry name" value="RNA splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="7">
        <location>
            <begin position="13"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2176305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="935" mass="105229" checksum="B67C54DE78C05E97" modified="2022-01-19" version="1">MFSATKDFIGKPAPANYVAGLGRGATGFTTRSDIGPAREAQDLGYVPSFKQYKWQSKRSSTNSLVNNREAQKAAAAKKEDDDDDERFQDPDNEVGLFSGAPYEEDDEEADKVWEMIDAKMDERRKARREAREKEELEKYRSERPKISQQFADIKRTLSTINEDAWNAIPEAGNLTGKSKRKQPKTDRFTPLPDSVLAAQRDKNQLANTIDATDQTLGGIATPSLDSGMMTDFKQIGEARDKVLGLKLDQLSDSNSGKTNIDPKGYLTDLNSVVLKSDAEIGDLKKARLLLNSVITTNPKHAPGWIAAARLEEVAGKMGTARSIISKGCDECPKSEDVWLEAARLNTKDNAKIILANAVRHIPQSVKIWLKAVDLETDPGAQKRVLRRALEFIPNSLKLWRAAINMEDNPNDAKVLLSRAVELVPLSVELWLALARLESYANAKKVLNNARKNIPTAHEIWIAAARLEEQQGNDKMVDTIIQRAVNVLSESGTVMDREQWLAEAENCEKTGAIGTCQSIIRATLALNIEEEDRKKTWMDDAESCIAHGSIECARAIYAYALKVFPEKKSIWRRAAYLEKGHGTKESLEELLQRAVKYCPQAEVLWLMGAKERWLAGDVEGARTIIQQAFTANPNSEQIWLAAVKLESENDEFERAQFLLKNAREKSGTERVWMKSAVFERQMKNFQSALELLDEALAKYPAFDKLWMIKSQIEDMDLNNQAKARETLNKAVKACPKSVTIWILLARLEEKAGMLVKARSTLEKARYTNPKTAELWVEAIRIENRANNTNAARNLAAKALQECPTSSLLWSEIIYMEPRAQRKSKSVDALKKCEQDPLIVTAVARLFWTERKIDKARDWFQKATKIDADIGDVYAWWYRFELQHGTEEQQKVVIQKCVAAEPHHGERWQAIAKDMNNVGKKTDEILKLVAGSLEVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMC6</accession>
    <name>A0A8H7PMC6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Triacylglycerol lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_005728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMC6"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2176488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8568" checksum="9DDEEA286942D4B5" modified="2022-01-19" version="1">MSRGSGTWVIWNGNEYWNYMVKALALEGYCVYSLTYGLNPKLNSLIPIGGLTKMEDSEKELPTYVGNVLNVNKHPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMD5</accession>
    <name>A0A8H7PMD5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_005743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMD5"/>
    <dbReference type="OrthoDB" id="2402793at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2176503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="235" mass="26803" checksum="C86442ADBF4FDB60" modified="2022-01-19" version="1">MAEIKAGTPCTLLERLVLHSPRPSSPALRPGYRAKDLTALFQAAAATEEADYQCKNTYNGSELNWSIYPDDNEDENIVIDSFYEDGNAILYLHGAPLSKTFDIWEDNIDANDADYYSCTDCSPHALAEKDKENQPPSQFSVVQPVVTKKNHVCSTSRSHLMELQLRNFVSDVEALWRRSLHTKTKTTNFGKKGGRRNRVIQMTAKPNVRSRIPKNRYRVNILLPLDGRYLYSRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMF9</accession>
    <name>A0A8H7PMF9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_005619</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMF9"/>
    <dbReference type="OrthoDB" id="1690618at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23953">
        <property type="entry name" value="zuotin_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.840">
        <property type="entry name" value="Ribosome-associated complex head domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032003">
        <property type="entry name" value="RAC_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042569">
        <property type="entry name" value="RAC_head_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058871">
        <property type="entry name" value="Zuotin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16717">
        <property type="entry name" value="RAC_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26185">
        <property type="entry name" value="Zuotin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="100"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="292"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2176385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="429" mass="48805" checksum="7B3B32F94BB3156E" modified="2022-01-19" version="1">MSLTLDFLLPPPPSTWNSESSSVNHASITAPSERLLEPVGPHFLAYARRKRHNRTFSEDERHVAEEKAAMAVEEEEVDLEEEVIDPSLFNLDPAEWKKQDNYAVLGLTKLRYKATDAHIKKAHRRMVLQHHPDKKADKGDDAFFKCIAKAHETLTNPVTRRQYDSVDFGMAEYEARAPNAKSKGDFYKLWRPVFAREGRFSEKQPVPTLGDENSTKEDVEAFYDFFYNLQSWRSFEWLDKEGAEGADSRDDKRYQEKKNRAQRAQLKKEDNARLRKLVDTALGMDPRIAQFKAEDKKRRNAKKDQKAAEEKAAAEEAARKAEEERIAKEKAEADAKVAADSAKKDKEAVKRALKKEKKTIKGLVKDNNYALPAGAPDAGPTEIEAQLNKLDELMAKVKGLPEHEALRQALETGLKEGKLNEVFENEVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMM6</accession>
    <name>A0A8H7PMM6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycoside hydrolase family 55 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_005715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMM6"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000023">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000026">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018909">
        <property type="entry name" value="Eng1_septum"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051801">
        <property type="entry name" value="GH28_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31339">
        <property type="entry name" value="PECTIN LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31339:SF9">
        <property type="entry name" value="PLASMIN AND FIBRONECTIN-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10645">
        <property type="entry name" value="Carb_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034819227" description="Glycoside hydrolase family 55 protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="4">
        <location>
            <begin position="76"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="4">
        <location>
            <begin position="431"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Endo-1,3(4)-beta-glucanase 1 carbohydrate binding" evidence="3">
        <location>
            <begin position="853"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="800"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="807"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2176475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="898" mass="93231" checksum="80E86321D0747BD7" modified="2022-01-19" version="1">MVNFSTSSYLKATVSLLLCASALAAPAKDAVVKAAATAGTSCSGTLTPSVFSGEMWINSITHNGTSAFGPSGYTVYRNVKNFGCAGDGVTDDTACINNAISSGGRCGNGCGESTTTPALVYFPAGKYLISSPIILEYYTQMVGNALNPPTLIMAPSFTGIALIDSDPYLPGGANWYGNTNNFYRQVRNFIIDLTQTSATAGSTGIHWQVAQATSLTNLVFKMSTASNTGHQGIWMDNGSGGFMSDLVFNGGKFALWVGNQQFTSRNLTINNCQTAIYMNWNWAWTFKSLSINNCQTGLDMTAGGSSAQAVGSVTLLDVSISNTPVGILTGTTSSSQTKTSGSLLLDNVKVSNVPTIVKGSSGSTILAGTTGSTTVKSWGQGSLYTSTSGSGSFNQNNLPTAPTKGANLLASTGYFFERPRPQYENYPVSSFVSVKGFGAKGDGSTDDTAAIQSVLNAYAGCKIIYFPAGTYIISSTVTVPAGSRLVGEGWSVLMAKGSAFSSMSNPTPMLKIGNAGDTGVAELSDLLFSTKGAQPGAILVQWNLAGSSQGSSGMWDCHFRVGGAAGTGLQSAQCPTGQGFTATCEGAYMLLQLTASSSAYLENIWAWTADHDLDGSSQVSIYTGRGILIESTNGPVWMYGTAAEHNVLYQYQIASAKNVLMAMIQTETPYYQPVPPAPQPYTPNSALADPTFSNCAAGSNTCSLAWGLRVVSSSDVYLYGAGLYNFFYNYDQTCLTTENCQDSMVDLEANTGNVYLYNLNTKAATNMVVSGTTSLAKQADNTNGFCQTINAFLAQISTGTGSGSGGSTTTTTSSPKTTTTTKTTTTKTTTTSSSAAATTTSSSCNCGAGLSCCGSACYSPSQYTCIGTSLCPSGDQLCGTACYSPSQYTCNNGSLSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PN52</accession>
    <name>A0A8H7PN52_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4460 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PN52"/>
    <dbReference type="OrthoDB" id="2097874at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028031">
        <property type="entry name" value="DUF4460"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14687">
        <property type="entry name" value="DUF4460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4460" evidence="1">
        <location>
            <begin position="10"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="277" mass="30957" checksum="819D7F66E04189AC" modified="2022-01-19" version="1">MSNSAHSALKSLVRPYVKRILLKTHPDYFAQDTVKKKINAASLQSLQNVLSPLLKGSAQNTTKAHSEKPTKLDFYVKNGGNRSILKVEHKFPTSHAISIVEKWYTAASLLELCKKIGIQVMPSDIDAIQSMIDTLNKESAAAKRGRAPPLSLTQVFADELYRSHNMDPASIMPEQTTSIADNELLFFPPKMSEKSKAIMVEKLQKALPLLRPNRWWRKIPIVIVDDIADIDEIDTAGILVFAPNMSIEDMAAYVESSLATKEEEYQKIVRGNSYSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNZ4</accession>
    <name>A0A8H7PNZ4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNZ4"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="383" mass="43297" checksum="ECD3FE2BCC152021" modified="2022-01-19" version="1">MAAKLPKMQYVNLGPTGVRVSRICLGCMSYGDKNWAQWVTEEEESLPLIKQAYDAGINFFDTANIYSNGVSEKILGKAIKKYNFPRQKIVVATKLFGLITEDNVGYRGMGKSKEEVEGDGYINYQGLSRKHIFDSVNDSLRRLDLDYIDLLQIHRFDPSTPVEETMEALNDLIKLGKIRYIGASSMWAWQFAKMNFVAEKNGWAKFVTMQNHYNLLHREEEREMHPYCLDAKVGTLPWSPLAGGRLAGKNRGTTRSENQPEYSAAESEITDRVIELAKKKNVPAAQLALAWVLTKDVVSSPIIGAGKESHLIDGIQALSVELTEDEIKHLEEPYEPRVPVGHNGVTSGIVSHEKIKLRISSPYRFENEESSMPKWNMTLLQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQQ3</accession>
    <name>A0A8H7PQQ3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">eIF-2-alpha kinase activator GCN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003288</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5148094at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904688">
        <property type="term" value="P:regulation of cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000090">
        <property type="entry name" value="eIF-2-alpha kinase activator GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000096">
        <property type="entry name" value="eIF-2-alpha kinase activator gcn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022716">
        <property type="entry name" value="Gcn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056810">
        <property type="entry name" value="GNC1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056809">
        <property type="entry name" value="HEAT_GCN1_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12074">
        <property type="entry name" value="Gcn1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24993">
        <property type="entry name" value="GNC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25801">
        <property type="entry name" value="HEAT_GCN1_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24916">
        <property type="entry name" value="HEAT_GCN1_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="6">
        <location>
            <begin position="1377"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1551"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1670"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="6">
        <location>
            <begin position="1876"/>
            <end position="2086"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="2027"/>
            <end position="2064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="851"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2681"/>
            <end position="2713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="863"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="2689"/>
            <end position="2698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2704"/>
            <end position="2713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2178035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="2713" mass="297714" checksum="91735B088C0EC6A3" modified="2022-01-19" version="1">MTDSEGELSWPEYLKARVMLNITRSSVGDRLDFLQHSLLIRLRRHDLPEEALPGLLHLVFLTYTRYQDRDSRLAVLEVLKELNKWNAPVFQPTMVSALAREVERTNKQAADGTFATAAAHRFTLLTWVNLLLSQNLKGTDDIKSSEIANKLAKSQAILLSGLAEEKRKGIRNSAFSDTRRCIRQNASFIPALIDSLVSDAATIIPSYRNTVLVGTIVDCALRLKGKKIDGKAMVEQKKADLIQFYLQSVISSKTAVPTAAMVALNDFVRNNITEDNFEKNLMPVLEKMMLRAPELVLRDLAHMMPALSFDPSSLFANKLVEPLLNHMRSTSASSRTDAALLWQALCKICHDETHLSTICTNAGKALISGKVNSWEHRVLVYQSLASLSESKLPEVSQKAIEVYLTMVAKESNEQALAIAIQGLGSHISVLTSSAEVMSKHQQVVDKSLKAMVTGLASTKPLARKAWAMALGHIVLSAPQNGEHLAPVLPPLLTALFSTFKKIADKPLAFKDGPLEAYILVAIVSGHINSWGSVPANIATILKNEKYPSSILACNTKPSFFLLDRVYTKAVTADEGRWFVLALESVLANTSLESLEKNSATNHAAQATIWAITSHPEHAVRREAYNATKRLAQKVPEKSGEIIRTGLNSWLHDIENQAKDSVAFTSLNNQELIVEERAYRLSRVLTAISSFDPSLDTIIKERELMKSFILSHHQYIVSPNDKYNWITLLQRASVNPGSVVENHVDILRETISSNTADINQSKLFYKAAISATSTIVFVAPAATLEVVMEMIHGDLDAQQLKGIGLQEIAIWHTPEDQVYVDVLKRGNKNAVEDRNRKDYAEKKWEQSVREELAKKKGGNAGPKLTKEEQATLDAQRRKEKEIRSNVQKVHDKIVRGLHLVEAIVDGNTSDVAQYLVELIRLITKLAARKAGALVGESIFDTYIHIGHCTDESLETIRTVLGVATLRSMNFEPIPDRWTQEPLLDLVLRVMYRLRFITERAPLSSSSFAYCFPLLHRVITESGIACNKNTEEGKENALEQISIAVDIIGFHCANGAESLLPRQEMIESLLLTIKEFPQCAKTAKTSLVDLCDAMGELATPSEINILLQGVLSGESLVRVAALNGLEPLDLTDIDYSDELWIGCHDDEEVNAKLAKQIWDENAMDVDENYADTLLNYLVHDTAFVRVAAGKAFASAAQIWPDTIIAALQAVFAKYSVLARPLVPEYDEFGMVKPDSLNRQDPWEARAGLAMGLKEVGPHIDVSNVQSLINFLIHEQGLGDRHETVRQRMLEAGLSVVNEFGPDHVQIVLAPFEEYLSGNSTSNSEAEDYIRQGVVILYGAAAGYLEPGDPKVRNAVDKLIETLDTPSEAVQSAVADCLPNLIKMIKDDAPKLIEILLEKLVKGEKYAHRRGAAFGLAGVVKGRGIIALKEFGVMQALKDAVDNKKIYQYRQGALFAFETLSQTLGRLFEPYVIQVLPMLLTCFGDSNAEVREATSDASRVIMSKISGHCVKLILPTLLAGLDDRQWRAKKGSVELLGSMAYCAPKQLSISLPTIVPRITEVLADSHAQVQSAANKSLMLFGEVISNPEIQQLVPTLLDALSDPNKKTKSALTALLQTAFVHYIDSPSLALVIPILERGLKERSTEIKTKSAQIVGNMSSLTDQKDLVPYLPRLMPGVKEVLVDPVPDARATAAKALGSLVEKLGEDNFPDLVSDLIDTLKVDGGGVDRQGAAQGLSEVLAGLGLERLDGLLPEIIANADSPRSYVREGFISLLIYLPATFGTRFQPYLGRIIPPILMGLADESEFVRDASLRAGRMIVMNYATKAVDLLLPELEKGLFDDNWRIRQSSVQLVGDLLFRITGQTNKATAAAMMMDEANEKEDDDEEEAVGPELGKKALLDVLGKDKRDRVLAALYIVRQDTSGLVRQASLIVWKSIVSNTPRTLKDILPVMMSIIIRNLASPSYDRRTVAARTLGDLVRKLGESILLEILPILEEGLESNDEDTRQGVSIALSEIMATAGRVQVNDYVDSIIPSVRKALCDSSAEVREAAAQAFDTLHQCVGPKAIDEILPTLLNMLQSSDEASVHALEALKEIMAVRANVVFPVLIPTLITTPISAFNARALGSLATVAGSALNRRITTILNALMNSLSVEEDEETIQQLKDTTRSILLSIEDEEGLHTLMAMLQEYARSDNPIKRTGACETAGIFYSESKLDASRYVSDWFRILISLFDDRIPEVVKAAWTALSSVSKSVKKDDLDGLVSHVRRAVKAAGVAGVDVPGFCLPKGISPVLPIFLNGLMYGSTDIREQSALGVGDLISRTSGDALKPFVTQITGPLIRIMGDRYPPQVKAAILQTLSMLLSKVPTYLKPFLPQLQRTFIKSLTDPSSGIVRARAGSALGILISLQTRVDPLISELVSGIKAAEPGVKETMMNALQTVVEKAGSDLSDASKKGVLTVMSEGLGDHEDGTVVAAARLLGCVTKSLSSEETKYIIQTHVLIEQAPPLGSTLAVNAMLVDSPSQFEDLEITDEILEKILTDLSSEKPKIPEAAILALGKFLMTTEYQRTEIIEKIAKALADIIGQKTAGVGETRRLALVVVRAVGRRYPGLLEPYLDQLVPPTMGCVRDRNIPVKLTAERAVMYLFRLLEGEETLQSYLSTVDATAQRNIGDYHRRILSKLVSQEQQRLSQLHGAADEEAEEEDSEVWAVGSQASFETNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRJ0</accession>
    <name>A0A8H7PRJ0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reticulon-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_001799</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRJ0"/>
    <dbReference type="OrthoDB" id="567788at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50845">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="8">
        <location>
            <begin position="115"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2178952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="328" mass="36200" checksum="5F9DD2FCDA21AB8D" modified="2022-01-19" version="1">MDEQQTFTHPDLHPNPSAVSQSFPEPKDTQPSSETTVPDMSTTKEPALSTAVPSQPTLGTNGSAGSTGLSEKMELPPVVPQTEPSLSSQIQKDLQPAEPPVSFEQDPTQYVQARFWNLVMWHNPPKTAIYLIGSLLGLIITQHYSLLQIFAAFATLTIGINWVFVNAHVQGQKLFASNTAEINNATANPHRNRLQNPSQPLSRTRVTRLSNTLVDAAEVIANEGAKIVLIDDNKRSLKYLCGFYVLWTVAKYLPSRWIVGLSLGLVFTLPKLYYRNQDLVDARVNQATVLLNEKAQMARDLAQKHANDAYQQISTRVSGAANTPKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PST4</accession>
    <name>A0A8H7PST4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 6B homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_002068</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PST4"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000018">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000046">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="191"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="30"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2179218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="411" mass="46336" checksum="B8FF8ECF9DEADA84" modified="2022-01-19" version="1">MEEIGVQIVPAHKELATGKNKATLLEELAEQDLYTKLKKLQRHLEFLELQEEYIKDEQKNLKRELIRAQEEVQRIQSVPLVIGQFLEPIDQHTGIVGSTTGSNYVVRILSTIDRELLKPSASVALHRHSNALVDVLPPEADSSIAMLGADEKPDIAYSDVGGLDIQKQEIREAVELPLTHFDLYRQIGIDPPRGVLLYGPPGTGKTMLVKAVAHHTTASFIRVVGSEFVQKYLGEGPRMVRDVFRLARENSPSIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQTSNVKVIMATNRADTLDPALLRPGRLDRKIEFPTPDRRQKRLIFSTITAKMNLSEEVDLEDFVSRPDKLSGAEIAAICQEAGMHAVRKNRYVILSKDIEKGYKSNVKKTDINFEFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PU12</accession>
    <name>A0A8H7PU12_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PU12"/>
    <dbReference type="OrthoDB" id="2015405at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050268">
        <property type="entry name" value="NADH-dep_flavin_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466">
        <property type="entry name" value="FLAVIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466:SF1">
        <property type="entry name" value="FMN REDUCTASE (NADH) RUTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2180086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="307" mass="35583" checksum="08A11439D8ECE644" modified="2022-01-19" version="1">MRKVPQPVVVVTTARPENPEYRRGITVSSFTSIALHPFPLISFCVRKPSRASDLLHEAGQFVVQVLSSHQVQQSLAFSSPNQEGVDQFKDVPFYSDPQTHNPVLMGSVGAMHCSTHNVFVLGDHELWVAKVDRVDHGVGSMRGTRDESEPLLYHDRRYHGVGEEVFMQAFEDHTLDFRQWTHRAHVRMAWNYLREMNQEEATPLIKHGIESYYKANKDKIQFVYNETITGFYIDLIHKAVQKDKLSGRSEDDDFFEFLERYPILKDRKVIKDYYSRELLDSDDSRQQFIEPDLQPLPTVQQLANESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PU73</accession>
    <name>A0A8H7PU73_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_003603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PU73"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2179820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="139" mass="16127" checksum="587E24CD809A9286" modified="2022-01-19" version="1">MQDNPLPKSQFPLSADALKGVTDNWNSVTDNWNSVTDNWNSVTDNWNFSDRQLEFMTDNWNSVTDSWNSVTDSWNSVTDNWNSVTDNWNSVTDNWNSVTDNWNFSDRQLEFSDRQLKMPLKDVAINNLLPVCQGTRTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUZ3</accession>
    <name>A0A8H7PUZ3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM3</name>
        <name evidence="11" type="ORF">INT43_003761</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUZ3"/>
    <dbReference type="OrthoDB" id="29543at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120115">
        <property type="term" value="C:Lsm2-8 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01730">
        <property type="entry name" value="LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000007">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034105">
        <property type="entry name" value="Lsm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="16"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2179974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="101" mass="11240" checksum="BFF472D36E337BA7" modified="2022-01-19" version="1">MADINATIPDSGAVEEPIDLVRLSLDERIYVKLRGDRELRGVLHAFDGHMNLVLGEVEETITLVDVNEDTNEEVIRIVKRNSDMLFVRGDGVILVSPPSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PV02</accession>
    <name>A0A8H7PV02_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase epsilon subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">DNA polymerase II subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003776</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PV02"/>
    <dbReference type="OrthoDB" id="1707486at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22928">
        <property type="entry name" value="HFD_POLE3_DPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051377">
        <property type="entry name" value="DNA_Pol-Epsilon_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172:SF1">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="6">
        <location>
            <begin position="9"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2179989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="167" mass="18215" checksum="6AB2CCEFCD6AB4CA" modified="2022-01-19" version="1">MSSSIDDNELPKANVTRILKHALPASTALQKDAKLAISKASTVFINYLSATANDIAKSANHKTITAPDVFKALEVLELEDFVPKLQEAFTAFQQLQQEKKSRKKEGKTEGDEEQNEEGLSADEEEPTGASPKRKLAASELAEEDPKRLKTDADDETSTAVSTDPVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PV11</accession>
    <name>A0A8H7PV11_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PV11"/>
    <dbReference type="OrthoDB" id="10365240at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="100" mass="11236" checksum="963AF4AB1835E822" modified="2022-01-19" version="1">MDLPQPIPTPYPPTSSSNQVKDYQRILFNRAYGQDHVAAFGFSSPKQDFFDTPNCGSNSQTQQSQKSHHSQDDVGFEQVNNETTSLYQRPDKALDTARIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PV15</accession>
    <name>A0A8H7PV15_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial phosphate carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_008406</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PV15"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000005">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="55"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="152"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="254"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2180827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="37513" checksum="F1C0D887932421C3" modified="2022-01-19" version="1">MSLYPSREVASAVIPSPLSSNKERRPAFSPARYVAASINEKAFVASAPIELYTTNYFLTCALGGALACGPTHSMVTPLDLVKCRNQVKPGMYKGTFSGWATIYKAEGLRGVFTGVGPTAIGYSLQGTGKYGFYEFFKYQYSQLAGDEAAHKYRTALYLAASASAEFIADIALCPWEALKVRMQTSVPPFATNTAEGFNKLKSAEGLGGFYRGLVPLWGRQIPYTMMKFASFERVVELIYDKFLTKPKAEYNKFQQLEVSFAGGYIAGIFCAAVSHPADVLVSKLNNQSKSGDSPGVGALIKELGMKGLWRGLSQRIVMIGTLTAMQWLIYDSFKVYVGLPTTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PV67</accession>
    <name>A0A8H7PV67_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003882</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PV67"/>
    <dbReference type="OrthoDB" id="409173at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF33">
        <property type="entry name" value="NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2180094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="443" mass="49041" checksum="EC30EFBCA38D1743" modified="2022-01-19" version="1">MLSQANESDHLLNADVQANDTDISNRSHSRLYGTCDVQVDKDKVNTGDIDARWFSWKKLWLYTGPGMSIAYLDPGNLESDLQSGALAGYKLLWLLLWAHIAGLVIQILASRLGVVTGQNLAQLIRHNYRREVSFILWAFTQLAIIGSDMQEIVGTAIALKIMFGLKLWVGVLITGFDTVSFIFVQGTKKLEIGFMVLIAVMAACFWIEMVKSRPDIRQIFDGVVYPRVPSNAIVQAVGMLGCVIMPHNMYLHSALVMSRDLGKRATSKLREANFYFAIESGLALSTSYFINLAIVVVFAKVFYQPDMPAETPLPGLYDAATVLVKTLGESSKYFWAIGLLAAGQSSVFASTLAGQYVMDGFFGAIFRKDWHRIVVNRSVALVPSLLVAVLAVDRFDTMGELLNVVQCICLPTAVIPILKLSASKSTMTEEFQIQHTYLPYILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVB5</accession>
    <name>A0A8H7PVB5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_003958</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sal C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVB5"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051565">
        <property type="entry name" value="Sal_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233:SF84">
        <property type="entry name" value="FI23031P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233">
        <property type="entry name" value="SAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="260"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="157"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2180169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="303" mass="33555" checksum="AEA9361B734BAF5F" modified="2022-01-19" version="1">MSIQFLLQDGGDEWSHDEATSTSNLSASIPSLVAPPYPIHPPHELAPVNSLPVDIQALSISGRPKYPPAVPQPSNSADTRYMLPHTHLTYSRTRQHSHARSFSDFTHPYPSSHPPSSSARPSAPYLAAPHLCQHRRAISANTADFYTDSSWQPAECTSTATNTNSSKFKNIAPSPTRAKSALINTTDTTPDSPQDSNDEDEYEEERSPSPSNSSSSSSVNMGVDSNGRPNRYQCTYCQKAFSRPSSLRIHTYTHTGERPYVCDAPNCGRRFSVQSNMRRHLRVHRMGRQTKRYRGGTTHPAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVT1</accession>
    <name>A0A8H7PVT1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_008384</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVT1"/>
    <dbReference type="OrthoDB" id="285674at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06428">
        <property type="entry name" value="M1P_guanylylT_A_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="6">
        <location>
            <begin position="282"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2180805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="414" mass="45594" checksum="7C90733BC513708D" modified="2022-01-19" version="1">MHKAVILVGGPSRGTRFRPLSLNVPKPLFPVAGAPIIEHHLSALAKIDNLKEVLIIGFFEDNVFANFIDHAAVEYPNINVRYLREYQALGTAGGIYHFRDEILRGNPTSFFVIHADIACDFPLQGMLDAHSKHRGLCTLLGTKVPREQANKFGCLIARPETNEVMHYVEKPESFISDLISCGVYLFDSAVFSEIKAALDNKKNAHEENDYLWSAPDDRLRLEQDLLRPLSEGKKLYVFETQNFWRQIKTAGSAVPANAAYLEKYAAGAPERLARKKEGSPDIVGAVYIHPSAQVDPSAKIGPNVSIGPRAVIGKGTEGLRLALAVHLIDILSMQAGSCILHAVVGWDSRIGTWARVEGSPVQGHSTTVTRNGVKSQSITILGKEVSVKDEIIIRNCIVLPHKELKASFHNEILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWI5</accession>
    <name>A0A8H7PWI5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_008602</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWI5"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000015">
        <property type="entry name" value="Heat shock protein 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2181020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="366" mass="39152" checksum="6346FC6C25DA8F8D" modified="2022-01-19" version="1">MGKDYYKILGVSKDADDDAIKKAYKKQALKWHPDRNKDKGEEAKQKFQELGEAFEVLSDKNKRAVYDQYGEEGLKAGPPPPSGGGAGGFPGGFGGFPGGAGGPGGTTFSFTSGGPGGGFKSYRPSDADDIFKHFFSSFGGGGMGGMGGGMDDDMGGMPGGGFSNFSSFGGGGRPRSGFQSSRQASEKPPAIKRPLPITLEDLYTGTTKRLKVTRKIRDGASGRIVTTDKVLTINVKPGWKAGTKIRFPGEGDELENGETQDIEFIIEEKPHPTFKREGDNLTMKVQLTLLEALSGFTKQIKTLDGRTLKINNTTNVIQPGQESRVANEGMPNSKTGKKGDLVIKYEVKFPTSLSASQKEEIKRVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWS1</accession>
    <name>A0A8H7PWS1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWS1"/>
    <dbReference type="OrthoDB" id="2103474at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF2">
        <property type="entry name" value="PH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2181155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="152" mass="17371" checksum="61C700DC348F779C" modified="2022-01-19" version="1">MKFTLQKKEKVPVILSEKEAKILGEYKRRVEMFDQMFKLCCCWIGWDMLLDLIPVVGKIISLGFAVSLYRLASKADLSPSVKSSMRWHTTVNFVIGLIPIVGLIFDIFYQANAKNCRILEKFLYQRARTSPAQPMEPEAAPVKPAPTFNKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PX03</accession>
    <name>A0A8H7PX03_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_008873</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PX03"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2181290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="509" mass="55807" checksum="B6E4B5984CA5F326" modified="2022-01-19" version="1">MDETTPLVSKKQQQHWLGIKPSPWVLYPAFIFLGTVLGMVQGPFVQFLLDLLCQRMDTSTVSDRSREECNADSAVQAASSTLLMQTDSRYDILGMLSTVMYSSMSDKRGRRPILIINAFGFLADITLSYILARFHQVAPLWLLVVGAICQGLGGSSATLLMSCHAYAADCTTPGERTVVFGRLMASFVAGNFAGPTLAGYIMEKTGSIEPILIVNMAGLSMWILYLIFVMPESNRKVRENVSEDITEPSQPFWKRLNFYSSLSIIFTASPELANKASLPLLILTQMLSKTANLSFVCIVVLYVTYVFGWTPAQVGYFLSFENAASLIGLLFIIPLITKMHGKVSDEEDVNDPAVAGLHIMKLDLWMVRIGLTCLCGSMLLFSLANVGWVMFLGATLQMGGSLYIVSAKSLLVQLAGEDQAGQILGAAGVVESMVFTFAPILANELYSRFVFTSPWVVFGACTGLHASALFLSIFIRSKRQGSIILYNIPMPTRTFLCHYVAAQKVVNVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXK3</accession>
    <name>A0A8H7PXK3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_007059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXK3"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2182132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="86" mass="9387" checksum="B896088565E70505" modified="2022-01-19" version="1">MRASPVNKKNGYDDNVDIAIAVNYGSFTYLLRRELLTLAQSALAVVISLLIHSFRSSAFTMVYSSGPRGGGYFQSIDPPKSEVTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PY34</accession>
    <name>A0A8H7PY34_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_007417</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WHI5/NRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PY34"/>
    <dbReference type="OrthoDB" id="2417393at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013734">
        <property type="entry name" value="TF_Nrm1/Whi5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08528">
        <property type="entry name" value="Whi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="52"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2182487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="228" mass="25767" checksum="033BC11E6BBFA69B" modified="2022-01-19" version="1">MQTSSYEQENIDRLLRRLRTRLALASFKAQNGYEDVSLPRLEDKLLPSVELASSSTTSPSRSPRHYHTRPLNPYSSPYSSHRHHFDDQHEPPTPPPIAIFASPMSPRIPQSPVSDQRATPPPRSPFLPSKSLTSPGNRLSAKEKMRYFRRSASPSARPTSHKQHRHPPTHLSKVSTPTRKDHSPNFVRVRSMDSPTFDDMTLDQHDTDAANLLVMLHNCPSPARSFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYH2</accession>
    <name>A0A8H7PYH2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CsbD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYH2"/>
    <dbReference type="OrthoDB" id="2358123at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2182055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="20505" checksum="97E1EA6A6D0A9212" modified="2022-01-19" version="1">MSQQVLGKNVENLNSNVETSNMSKAEADKTIVKGIAHKYEGAVKHALGGITGKPSLKETGEETRNEAIEQIQVAKAVRKNSLGQDQKPENPRQNTLQDSEEQGIPDAEYVIQHERDEHPNNPVNEYQTRNPPNKEARADASQEKEGQRDQHLHKQLNKRENPEADPSILRTQRSQANDQNNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYR4</accession>
    <name>A0A8H7PYR4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_006834</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYR4"/>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2181909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="45433" checksum="D41488ABE25D529E" modified="2022-01-19" version="1" fragment="single">ESSPSSVSDSSTLDVRLKEKGMHEPEGKTSPIAWVALISLWMLCSASSIMWLSFSVVSDISRQWLSVDLSAVNWIANATALMSVTEHGWLLVQSNRLNLPTWCQISYHYDRAVFDFCTTDYINYTSHYAAIPLGAAISQLAIPAICKSVEEFPRVVIVSAVYSTLAAAPFFFLPGLPKDAPSFTASSKRTPFLKACRALFKSVNFLLLMFMFSINLGLESSIVALLNPIMLPYGYTNEQAGIAGFVRLFSGFLAGAVTGPLIDRTGQHMLILRLFVPLLAFTYVMMYIQIIPNAILVVCMACVLNGFVTLLLLPTMLEIASEITYPVSESLSTSVLWAAAEIASFVMTLVMDLMKSGDKSTPPNNMQNALLFAMVLACVGTIPIVFFKGKMRRLAQDINFEQVTTKDDNEIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZQ9</accession>
    <name>A0A8H7PZQ9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_007028</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZQ9"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF55">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="520"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="565"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="605"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2182101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="642" mass="73287" checksum="AD52A9C199C95D94" modified="2022-01-19" version="1">MLSKFMDRHRSKIAKFRYFNESKHRVLPGIVREQPSFAKKSLLFLQVARRGTLKSEIQNSSVGVQPQDRRHQKIWPFQESTVPLYLALNNWNQAMVLKYSARCWFVAAAILAACQCISAFYIPGFTPVSYKDGQQVQLDVNKIFSKNAQLPYAYSELDFVCQPKGSVKRTWLNLGEILRGDRLVSSDYQLLMKKDNPCQPLCTKMLSETQINEARQLIEEDYSVEWIVDNLPGATAKREFQDGRKMYVAGFPLGQVQDEKVYINNHVSLVFLYEKNAKKPEEQYIVGFEVYPESYDGESCPEELNHPMQELTKETTIVRYTYSVSWKETNEITWSSRWDMYMTTTDPQIHWFSIINSLIILVFMTAMVALIIMRTLNRDIAMYNDEDVEGAEEDSTGWKLVHGDVFRAPKHSNLLTPVIGSGIQVLVMIVLSLLFSALGFLNPSYRGGLLSNALFYYAFGGLFAGYASTRLYMMLQGPSWKSNALVTATLLPATMFALMFILNCFVWAKHSSSAIPFGSFFALFAIYLFIALPLVFVGSAYAMRQKPIEHPVRVHQIPRQIPEQIWYLSPNVSALAGGLMPFAVIFVELFFIFKGIWANQYTYFIVGFLVLVFLILIATAAEISIVVVYLQLQAEIDAKWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q036</accession>
    <name>A0A8H7Q036_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q036"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2183438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="84" mass="8851" checksum="37107866D1E29529" modified="2022-01-19" version="1">MMPTLRQIVDAAAGSHSFALAALCLDCSPCDGFSALQNRTLAVFRDLGSSDAFQLLLCLSLGSSELKPTKDVASFSTPTIKAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q083</accession>
    <name>A0A8H7Q083_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_006563</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q083"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="45"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2183557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="274" mass="31119" checksum="3BF26F74B0325AC2" modified="2022-01-19" version="1">MSNLTDHLSDNPPQYRSFRPVYSKATYDLIYDYHKQKGGLFNVAVDIGTGTGQVATELAQTFSHVHGTDLSEKMLESAVKGPNIDYQACSAEKLPFDDNSVDVITTAQAFHWFKHDDFFKEAKRVLKPQGTIAIIGYAFARIKGSRNASELVEKLGLETLGDYWDQGRVLVDNLYRDIPIPYANTDYYFSPEDADITNIGKITPKPIMEQDMSLETFRSYIKTWSAYANYMKDHTEDPVDKMIEDMAVLLKTNKPEEHQITVEWPAVLILTTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0G8</accession>
    <name>A0A8H7Q0G8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0G8"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033986866" evidence="1">
        <location>
            <begin position="23"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="364" mass="39601" checksum="9AFA5AD268FCEB65" modified="2022-01-19" version="1" fragment="single">MPVPLACLLIFLASNGIRNTVAIPLTEDVLAAQTFTANTIGSSFENISPGKDMVLIEPAIDPFGFLVTTATFSSSATSMASSSSNAIQSGSPAIWVEQPSAAITSRLSPTFVPATTSLTPSIISVMNLPQGVPQCYAGTVPFTQYWIPKENNWDENEEGEKIWLEKTGNEPLLDENNATIAFVSKSTKDKCNLEGTCLLDDGNLINVVGGRERFKIIGQRGRSKNIFGFGNRKRNLAPFVSVASNDLPHGQTIFLPQLNGTRLANGMIHNGCVRVDDDGTSFDGCQLDFFVVSYVNYLVMGLGTQVSMEFKQCTPLNYATEEMLRWMEADTTAVSHILDDQREDWNNLMAELNAKNKLPGPVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0I5</accession>
    <name>A0A8H7Q0I5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">INT43_007406</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0I5"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031090">
        <property type="term" value="C:organelle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20341">
        <property type="entry name" value="BRcat_RBR_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23820">
        <property type="entry name" value="RWD_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000051">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="167"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="171"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2182476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="384" mass="44146" checksum="3EB08D43BE9008BD" modified="2022-01-19" version="1">MLYLIRVVILTQQQSIFTQQFIYEYHQSTEGYKIASGTLSVNTELPNHAVKVHIGGDCMTLHYLPPVALEFTMPSGYPMQQNCEIAVKCVWLNQHQIAALEEKLDYIWQNEKNVVYLENGKHLKLHHHQISLIANGISTEVILSGVTLQTILQQHEKSSLQDIFSHTSFVCGICMEEKKGESCTQLDKCGHVFCKVCLAGYFSMLIREGLISQVRCPDLECSQNKEGGNEPPSREQLILITGEDLANRYDRLLLQQQHQLDPQITFCPRLQCQEPVRKDPNYEKLCYCTACGYAFCLLCQKTWHGPQMFCQFKNTPKIIKEYLDVEDNPEQIAHLEAKYVVAYLWRKRLDAMHFNSQGTLCHMRLFEGVADVDVFDDFLPPFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0Q4</accession>
    <name>A0A8H7Q0Q4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LON peptidase N-terminal domain and RING finger protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_007512</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0Q4"/>
    <dbReference type="OrthoDB" id="264917at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16514">
        <property type="entry name" value="RING-HC_LONFs_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF42">
        <property type="entry name" value="LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN C14F5.10C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="203"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Lon N-terminal" evidence="6">
        <location>
            <begin position="286"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2182581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="57861" checksum="D9CADB9CC2ABB2A0" modified="2022-01-19" version="1">MMTAVEVGLHDIRAKDRLAYDTDSRRPCDSKLFSKQEEGFDNSPLDELGLAAEALSCPVCSKLFDRPITLSCGFSVCISCLPQFDPATVENFDCPVSECAERSHIFGELKVDVTLHKLVQIVSKEMLSTGRLISLIFRNPTPTDSAKQFSEHLLAESYIDTTPCSSPMSVKSSTDSTCSTLDGSAISEVELPWNKNLLNELECQVCYCLLNEPLTTPCGHTFCKACLLRFADHSNVCAICRSHLPISLVLQAHPLNTSISYLISTLFPYEQMERQETLNKEEEQASSYTPIFVCNLAYPTIPSFLHVFEPRYRLMLRRCVAPGGSRRFGMCIGLPDKSFSQIGTMLEIQDVEPLSDGRYIVRAVGSYRFRIKQQGMRDGYHTAQIERFDDEPEFDENDNWRSHNIISDLGQAPRTIESMVEEITQFGKLLQLSNVPWILQRVIRTNSKMPTNPSALSWWMAATIPIDDHEKVPILQITNVRERLTLICKWIQQVKEQWWFGPLMNGLSMTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q165</accession>
    <name>A0A8H7Q165_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_000423</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required both for recombination and for the repair of DNA damage caused by X-rays.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q165"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19513">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000008">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000092">
        <property type="entry name" value="DNA repair protein Rad51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011941">
        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02239">
        <property type="entry name" value="recomb_RAD51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="8">
        <location>
            <begin position="92"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="9">
        <location>
            <begin position="271"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2184514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="334" mass="36030" checksum="485391FF7F86A5B9" modified="2022-01-19" version="1">MTQTTVEDELVEESGPILIGQLEKFGVSAADIKKLQEAGLHTVESVAYTPKKGLLAIKGISETKADKLLTEASKMVNMGFTTAMDIHQRRQELISITTGSSDLDKVLGGGIETGSITEIFGEFRTGKSQICHTLAVTCQLPVDMGGGEGKCLYIDTEGTFRPSRVLSVAQRYGLNGEETLDNIAYARAYNTDHQIALLVQASAMMAESRFSLLIVDSAMALYRTDFSGRGELAARQMHLGKFMRNLQKLADEFGIAVVITNQVVAQVDGAASMFNPDPKKPAGGNIIAHASCTRLYLRKARGENRICKVYDSPALAENEGTFAILEDGIGNAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1C3</accession>
    <name>A0A8H7Q1C3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sorting nexin/Vps5-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1C3"/>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030905">
        <property type="term" value="C:retromer, tubulation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053055">
        <property type="entry name" value="VPS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sorting nexin/Vps5-like C-terminal" evidence="1">
        <location>
            <begin position="244"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="502" mass="56754" checksum="A053251853A5BFD0" modified="2022-01-19" version="1">MFRITALRSSANLIKREAHPQGKTSMSLQQIIAVVANRFSFAEANPKAPQRTGPTGPAIAIAAVGLGVGYWMFGSKSHGKAKEHASGDLSLKHEDATTHSDKFCWPEMLKSHSTWRDQDVGYYIHIIIENSDLKRKEPVFWLESSTNLNKYIHKQRRFPRSISDFRRLAVYLNAAYPNAFVPALPHAKPFNLQRWLDIVCRNDRLRESEALREFVESEVGFYPQSIGATARRRAVSLLPTGSGSSDTVEDIDFDFIDTKRRIEEFERNMAPCTKKCEMEMNYRKELAVAQADIGSEFVSLGAIEREPGLFLYVQTKPLVFKNLAKAFNILADLERSKAASQDSTILDQMKYQLFNSQAAQEVLHVRLKALSEYRDCSRITHTRLKAMERLKFSNSIDHSTVNDAINDLKEARANEAESKQKFDKINSGIKKDICEDFPKDVSQDIKKALADHVKAQIRLHKRELAIFEGLRPYTADLGSSPTNISTVSIQFSLSEANDSDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1U1</accession>
    <name>A0A8H7Q1U1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1U1"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="87"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2184557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23715" checksum="6C7FDAFC43FA36B4" modified="2022-01-19" version="1">MSSSSSYELYYLETHGLGLLARILLSMGGFEWSDMFPKNWSEEKATTPLGKLPVLTETRADGTKFVLAESSAIYSYIARKAKLHGDTEEESALIDQFYSSWYSTVVSGRQSRNLRESNPEQYKVEYSKYLEKELRPTLAKHEQHLASTSSGYYVGNKLSFVDIATKMAVDRINSHEVEITEQAYPHIYKLVQEVSELEVVKEQLSRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2S4</accession>
    <name>A0A8H7Q2S4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2S4"/>
    <dbReference type="OrthoDB" id="9999611at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="218" mass="23380" checksum="C5AEF66DDDAC0006" modified="2022-01-19" version="1">MSNQESYPHNAPVQQQQPAQIPHNQDTFVPMNLSNQQPTPVQAPPTSTTSVPAPAPGFAPASNIPPQPMQAMPDTSNPYNYPQNPYGDGSTPGYGNTPATASHAAPLHNDTDPQFKKMTSSWSYATGLMQEQLGSIIGNDDWTSSGRAAKEKANQEWSEADNLRKSGVPSRIGGEYESIMGTIMQKVGYVAGDPEMEAKAALRAKQGREEVARSSGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2S8</accession>
    <name>A0A8H7Q2S8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">COP9 signalosome complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_000805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M67A family. CSN6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2S8"/>
    <dbReference type="OrthoDB" id="1378at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08063">
        <property type="entry name" value="MPN_CSN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033859">
        <property type="entry name" value="MPN_CSN6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF8">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="MPN" evidence="4">
        <location>
            <begin position="33"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2184892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="338" mass="37379" checksum="4C04FAFDE84724A1" modified="2022-01-19" version="1">MSAMDIIEENKTAITKDSSNVFSNAQNVSGLNISVHPLVLLNISDHYTRIKVQNPNLKAQESVFGALLATQSGREIDVVNSFELLHSRDESGKVTIDKDYLVMKQEQLKQVFPQLDLMGWYALGAIPSVSDIHIHTQFFDINESPLFLQLNPNSLTANGNKELPIAVYESIIDIIDGQAQTLFVKTQYKIATGEAERIAVDHASRPSLSADKHGAGGSLISNLTTQRNAIEMLQMRIRILLEYLKDTEAGKIPVDHDIERQISSLCNRLPVVNTKEFNAEFLKEYNDVVLTSYLATITKGVNSVNELIDKVNFTHNVPGSLMGGRGPGSRKGKARTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q361</accession>
    <name>A0A8H7Q361_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q361"/>
    <dbReference type="OrthoDB" id="2244689at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2183811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="126" mass="14446" checksum="A70CE8C152AA8ECD" modified="2022-01-19" version="1">MSLAQHVATYCDLLVDASTDNVYIRSPQQLSKAVEIAVYVECEMAALDAQEVTNTREEASKLSENSKKITHEMLLDAHHTLYKALISNSNTANEMFWHIINSYRFLNRPEETCQEIVLEVSYHWPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q484</accession>
    <name>A0A8H7Q484_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_000290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q484"/>
    <dbReference type="OrthoDB" id="10260443at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01115">
        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14478">
        <property type="entry name" value="SPX_PHO87_PHO90_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF92">
        <property type="entry name" value="LOW-AFFINITY PHOSPHATE TRANSPORTER PHO91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="620"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="649"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="688"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="733"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="785"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2184381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="804" mass="88299" checksum="1526EE34D965EC9E" modified="2022-01-19" version="1">MKFSHQIHFNAVPDWADYYLPYSNIKKLIYQLEKDKVSGKLGHGVQDDEEGHVDENTSLMDATQECNIKISNVLDKSLDKIVAFYTKKEAEIYSELDQLIEAVNGLQSSVDSLPQDDETHAPAWPPARPKAHSRRRSSISQPSGRFARRESTLEGESDLPPTIITHNIADEQVALLLGSPKDIEEEDVEVALVDLRKRSVDLFVLLSELKSFVALNLTAFGKILKKYDKITNSDLKRTYISNVVNRTYPFSNTTKSELNNRIQTVERIYAQLATDGSLDDAINELKSHLREHIVWERNTVWRDMVGQERKAVSLAVQSSTPTKISTPFGKFAITFAQLQKVLTAVVCISVFLVLYNVKTFEGVEESNCFAILIFASLLWATELMPLFVTALLVPLMVIMLQVMRSDDGNDSRLSAPDATKKVFSQMFSPVIMLLLGGFAIAGALSKYGIAKAMATFVLAKAGTKPSRVLLMNMFVATIASMWISNVAAPVLCFSLIQPILRTLPVNSSFGPCLILGIALASNIGGMASPISSPQNIIAIQNMNPPPTWGEWFFIAIPLCLIADVLTWLVLLWSYKPEQSTGQIHSIRQSSDPVTWTQVYVAGVTILTIVLWCLSHAYEQVFGDMGVIAILPLIAFFGPGLLTKDDFNNFLWNVIMLAMGGIAMGKAVESSGLLHTVATYIQANVQGMTAFEILFVFGCLVLVVATFISHTVAALIILPIVAQVGAELDDPRPRLLVMGSALLCSAAMGLPVSGFPNMNAISIVDEIGRPYLSTSDFLKNGVPSSLLALLVITTFGYLLMSIVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4R8</accession>
    <name>A0A8H7Q4R8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_000579</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably involved in translation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4R8"/>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01160">
        <property type="entry name" value="SUI1_MOF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="5">
        <location>
            <begin position="30"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2184666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="112" mass="12582" checksum="6CC97F70014E5E88" modified="2022-01-19" version="1">MSDQEDLNAPYDPFADVGEDDKGAQPTGYIHIRIQQRNGRKTVTTLQGLPKEFDAKKILKVFKKEFACNGTVVDDEEMGQVLQLSGDQRIKIAEFLVSQEIAKKSDIKIHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4X9</accession>
    <name>A0A8H7Q4X9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_002329</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SHO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4X9"/>
    <dbReference type="OrthoDB" id="5983572at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd11855">
        <property type="entry name" value="SH3_Sho1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035522">
        <property type="entry name" value="Sho1_SH3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="208"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2185891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="264" mass="28955" checksum="A073951305F9261E" modified="2022-01-19" version="1">MDYKLLTTNPVLLGSTLLLMIGWMIAFCGLCASQSLVFGISWWFIMYQFLVVLAVLTVIVTASIAQYRLVILTFLAISIMYSTNEISKYLHSNLSTSAAITTGYIFIAIVQFIWVFVFGSTEDSKLGSVIDNLTAHSAPVQEMKTNSSVALAAPANQYAPSTFTPTQFNNSQTTIQHQPSIKHTSYISGSNHSAPDVESTVVVSPNQEYPISVVALHAYEANPEDPNELSFAKGDMLDVHDKRGNWWQARKANGAVGIVPSNYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5J3</accession>
    <name>A0A8H7Q5J3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5J3"/>
    <dbReference type="OrthoDB" id="2107880at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061671">
        <property type="term" value="C:Cbp3p-Cbp6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037653">
        <property type="entry name" value="Cbp6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250:SF1">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20180">
        <property type="entry name" value="UQCC2_CBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2185950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="123" mass="14245" checksum="59CC89ACB73E3003" modified="2022-01-19" version="1">MSSTAARNEIQSLYRSYLRLISEWPVDRVRPNRDMKKVLTARVQEMFRQTDNAQVDIQEARRQLDALERLLSNEFKEKYPLSDKIVSPASNPNYYSRLVASLEAQKSNKNGGPFARFFGSTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5R1</accession>
    <name>A0A8H7Q5R1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">INT43_002242</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18659">
        <property type="entry name" value="CD2_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000015">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056302">
        <property type="entry name" value="CHD1-2/Hrp3_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025260">
        <property type="entry name" value="CHD1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF14">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13907">
        <property type="entry name" value="CHD1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23588">
        <property type="entry name" value="HTH_CHD1_Hrp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01176">
        <property type="entry name" value="DUF4208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="14">
        <location>
            <begin position="249"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="14">
        <location>
            <begin position="349"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="454"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="756"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1005"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1042"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1259"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1300"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1464"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1061"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1306"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1316"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1330"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1464"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1474"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1500"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1522"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1545"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1563"/>
            <end position="1587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2185805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1605" mass="184398" checksum="128564ADF6A94353" modified="2022-01-19" version="1">MYTEESDQYLSSDSLSDVEKDLRSPQNGWETPSDADGRTGHSEAPRKGRRRIVAVSDDEDEENEDYSEDQSGDDDRLSPQTRNGRSSLSQSQKAEYLDPDLYCLRRSGRTNARSRQPIKAASKSLYAENSSVDEESDSYVSPTSRRRVKHEMSSDDEALASETSDEEEESDDSFGSSKPVKQSSKARPRAKASRQSSDFEDWEAWSGPRYSTRERKIKSYNEDLMDSGPSDLDMQLEATTPIPETEEGETIESIHDHRRVEGSEDDAHDRPEHNIEYLIKWKGRSHLHDTWERFSQLNEFKGFRKVENYIKSNVYEVTRFRRHPDTTKEEIEQHDINIERHRAELEEWKTVERVIGMRDGMMVDQRGYPITEYLCKWKGLRYDNCTWESAELIVNSFQAEIDDYLDRDANLKIPARSALITRSRPAFKKMQEQPSYIKGGELRDYQLLGVNWMAHLWSRNENGILADEMGLGKTVQTISFLNYMYHEQKVYGPFLIVVPLSTSENWMQEFKQWAPEMNVICYIGNRQSREMIRAHEFYQQDSNSKLKFNVLVTTYELVLKDRAELGGIKWQYLAVDEAHRLKNSQSQLHEALHGFQTNNRLLITGTPLQNNIKELSSLVNFLMPSLDISEWDVNIDEKDDQERQKEKIAKLHTQLKPYMLRRLKKDVERSLPSKTERILRVELSAMQMHYYKSILTKNFAALTHGNEKQKKQWLNIAMELKKASNHPYLFPDAEPKTDNKVELLKGLVTNSGKMVLLDKLLTRLKSDGHRVLIFSQMVMMLDILSDYMSMRGHPYQRLDGSMRPEVRNKAIEHYNAPDSPDFVFLLSTRAGGMGINLVTADTVIIFDSDWNPQNDLQAMSRAHRIGQTKSVNVYRFVSKGTMEEDMIERAKKKMVLEYLLIKQMDTSGLSLMEKNTISSASNKSSGNGKIGELPFNKDEMSAILKFGAQKMFQDEQNTQKLDDMDLDDILARAEHTETLTNQVGQSLGGEDFLAQFQVADYGGTDDISWDDIIPESERPPEPEEEAENLALFDRAAKRKQYNYGEASDDNESVNGEDGTTKKRKVARSGTKKRSSGASNLLTERDLRAIIRGSTKFGDARDRYDDFVADSDLLQKDPPLVMEASDDLYQTCLTAVRDHLKQNRTADEEDLSKPVLTTKHKAILITWRDINSVNAGQVLQRVDDLKVLYTMLKDSQQLSKFRITTTLKPVQNWACQWGYREDSMLLAGIYKHGFGSWTKIQQDETFGLADKFFLMNDDDEASDDKKEKKRAGKAETKAPKAIHLVRRGDYLLKAMVVDQQSKQAAANKRKASHHTKSSPSPGNSTPRPKKTPSSSSLKASPVSASSPVIKSKPVKSSPAAEEGSGYESMDEEKVSVVMKPVKSKLVRLRDQGLQSTGLERSALIKTCISAIGEHISHVAQKQPSSGAREKLTNHMWWYAKRYWPFNKIKHQQLKTIYDKLQVTNSSASPSLASPRPDHKSSRHSSDRNRSSSHRDHKRRHYSDDSEDDRRRSKTSSSHYKRSRRDESTSRERGRSSRRSTSSSRSPSRRKDRSSNRHRRRHRDKSRDRSGSRDTRRRDNTHRDKDRHESRRQRSSSPSRGDSRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6L7</accession>
    <name>A0A8H7Q6L7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6L7"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663:SF11">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2186223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="73" mass="8122" checksum="9F92899F0089E673" modified="2022-01-19" version="1">MLGPILTKAVADNKKVTLVKVDVDESTDIAAKYQIAAMPTVFAFHNGKVVDQFVGMRDKKFLTQFVNNHGDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6M5</accession>
    <name>A0A8H7Q6M5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trm112p-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with TRM9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRM112 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6M5"/>
    <dbReference type="OrthoDB" id="2187549at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21089">
        <property type="entry name" value="Trm112-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000018">
        <property type="entry name" value="Multifunctional methyltransferase subunit TRM112-like B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039127">
        <property type="entry name" value="Trm112"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773:SF0">
        <property type="entry name" value="MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773">
        <property type="entry name" value="UPF0315 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158997">
        <property type="entry name" value="Trm112p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00065633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2186064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="13886" checksum="31C5D7CCCD9F6EBD" modified="2022-01-19" version="1">MRLITHNMLQCHVKNCNDNNFPLRLEEVEVELVEADFQADFLRNILGKLEWEALVNTAVQVGNTSLPATIPDNAADNEEFLKVLHNALLETHIQSGNMVCPNCQHVYPVKDGIPNMLLAEHEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6Q7</accession>
    <name>A0A8H7Q6Q7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6Q7"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070813">
        <property type="term" value="P:hydrogen sulfide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051682">
        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF8">
        <property type="entry name" value="METALLO-BETA-LACTAMASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2185746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="307" mass="34258" checksum="44740B7C257DFD47" modified="2022-01-19" version="1">MHSPNTEPTVHSIHEPVTGTWQYVIADPSTKGAVIVDSVLDYDKEDGIVGSGSADRLLEIIASNNYQIWYILETHAHADHLSASRYLQNVLASQQPNEPKVCIGHRILQVQETFGKMYSIPPAELENAFDCLLQDHDELTLGNLVIGVIHLPGHTPDHVGYIIGTNVFTGDSIFNPDVGSARCDFSGGSANELFQSTQKLLNLPLHFRLYTGHDYPPSDRQCSLTTVESKALPFATVEKQRKENKHVRSGTVETDFVTWRNERDQNLQLPRLFHASIRTNIRGGRLPKTSEDDFKIVNVPEGTIRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7I2</accession>
    <name>A0A8H7U7I2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7I2"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034315">
        <property type="term" value="P:regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057334">
        <property type="entry name" value="PH_2nd_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051279">
        <property type="entry name" value="PP1-Reg/Actin-Interact_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112:SF66">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25353">
        <property type="entry name" value="PH_2nd_LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="105"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1074"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2174156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1085" mass="120920" checksum="E14A1921BD77322A" modified="2022-01-19" version="1" fragment="single">MSLHSSDSVRSAPLRHQASISSHDALSYITPSTDPNTLQRTTQPPLTRSNTANTMGSGSLHGMPLSPPHTPIPGDGGQLPFYPPSKAEKIAASEAMNQNETSIHVVYASDAIHNFEKGLLSKTKKEYIVLTNQHLIRFKNQNKANQSLDLFSSNSSRTTSISSNSKILTSKDHFMFRLDSIIASQATGAAPYSFRIDYMVDAGARQPSSVTLTVESANERAKWLDRLRSLTRVYLPRSNFMPREEKLRVAERLIKHREVADDGDETVTHKVVYKERRLKSDNSGLYKDVFTLINIAIGQFSLYLLPSITTDDDHIKQVGRDRYGLLSIQSINLDTTDDSLKITFLQTQGDPKKIEIASCHSEILVQDIRRAIYSLVPLYTTPPYQLGAPDAIRNTRIIPMYDSTRSENLGFDRLIEAYCAAFNLNKKRIVYSIEPSADGEEGLSITLLPVNEVNDSPEFYSKFELLAFFRALRHNTTFRAISFNGIKLSELQSWTIKGAVGWMPTMDDGIQLDNVLASEIYSLIISNKKLRQLDLSSCCIEGTDSEQSSISMIGRVLKTQKTGLNSILLDNNRLSETDVRSLAAGIQVARKAIRELGLRNCSLEGAHIEIILQSLYTRSPGHLKYLDISQNCRNISSNQVDGILRRCKHIEHLFLRDTGYIPDFQNLAISHCKTLDLGMNPLTDDLILILCQWIGTPSFLTIQSLYLDDCNLHAGHVRDLLIAITRTGNQTLHLDLGANPVFKEVSHLPRLWYAIMKGYTPSSLSLKGIEWEENSLQEFLDAILDNQQLCKLDISAMHLIPRQGNVVGSDTIKKLGNLLERNRVLEELNLSGGVDENGGRIGLGKAISPALSSLNTNTTLKRLILYGVRFGDVGISAIAEMLKTNRSLMYLDIDDNSVTIDGYRILNEALVENSSLINMPRPRIDVRNQLKYLNETITELTLAENESRFFIANSAGTDSRRAKASLQLQLQVRKSAETARAKIGLEVDKIMLAVERNKDLWDRVQAQYRQATQNITGRNNYIDETQLDDLYPSGATVGSSNGDRSPPFGYPIAVGDWAAATAGHSYPSPRVRTRSNSATLSEHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7R8</accession>
    <name>A0A8H7U7R8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_001502</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7R8"/>
    <dbReference type="OrthoDB" id="21060at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08045">
        <property type="entry name" value="HFD_TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045144">
        <property type="entry name" value="TAF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007900">
        <property type="entry name" value="TAF4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138:SF14">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05236">
        <property type="entry name" value="TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID component TAF4 C-terminal" evidence="10">
        <location>
            <begin position="356"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="28"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="229"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="488"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="562"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="601"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2172025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="677" mass="72884" checksum="2CEFBFB075B63DAF" modified="2022-01-19" version="1">MSDKSGGKPIPTNLADFDFSNIPSDIQSILDDTTFPDSGSHGTGQSFESITQDMLQQGDAMSINDLLGGHHTPNMQNQPMSGNGSTGFTDQSNASSAMQSPASDGSGGRMPNTNRQMLSSSPIVSSPMVKNEDALSPHSGVSMSPSPSPSRIGTAVLTPRPSTPNVGTGEGTPEINPADAYSIKARLPPERRAKWEELFEKLKTGRMTANDFLSESQLLLGSQQYQQLQDLKNRPAAPQQPQQPQQQQQSQQIRMQASNGMGDNTDANGRKRAGINPDTPPQFAQTKRFKSENTQPGVVMGPPSGTATPYRPNSQITTPTIPGVQTPRPAGTPGRPPLANTGASNTQDERVDYDTLTDVMGYAGVDLKEETEQSLIHGDTGAAPADGVDRTKMQHFINMTMLKVIVSKIAGKSAVSDINPDFLAYLALATQDRLSGLVEQMVKASKHRVLSQTFDAPPIDEATGQPLYKIIVQQDTRKQLLAIERVEREEERRRKEAISEKERRAQQGDGGGDDDDKPKKKKQKAMGPGVTARTMSEDMRNKKANETALMSAGGKRMSWMMSAANDAPSPPAKSFTPTTQTPPDSEPAAPKTKGKRGRPRGSGASGRAGTTRADSNSNVNLFLPPSTVTRPLRAGDASSRKITVRDAIFALERERDNGIGTSAEERILLKVYSKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8N6</accession>
    <name>A0A8H7U8N6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_004869</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8N6"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF30">
        <property type="entry name" value="GLUCOKINASE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="7">
        <location>
            <begin position="27"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="8">
        <location>
            <begin position="228"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2172327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="492" mass="54855" checksum="B1BDE21A707388E7" modified="2022-01-19" version="1" fragment="single">YYIHFMGRKSIFALGEFQGAEEQIKAVQSLVDELYIPADKLRKLSANLVKQMEEGLQKNDSSVPMLPSWITAHPTGQETGEYLALDLSGTSIRIYLVTLHGQGRVTTRQQKYNIHDDIRKSNISKIVDFLAECVDSFLTFIGRSHMTEPMALGFVVSFPLQQTAMNKGTIIRWTKDFDVKGAEGKDMAELLQVGLNKKSIPVHVKAIINGAVGLLLAHNYRSLDTLLACTVSRGTNAAYWEKVSDIPKLAKPEAKKPVKGDDTDINMSKLELSEPSQGDEMIINTEWGSFGDDHADLLPLTMYDNRVNRESTNPGIHSLEKMVSGLYLGEIVRNILLDLLDRRLIFSGHYSIDMNMPYNFESSYMSAIESDDSEDLEDTKHILETIMNIEHTSLTDRQITKKICALVGQRAARIIAAAMSAVIYKRNALETGLTISVEGTIYEHYPEFPNRVNEALRELFGEKVDRINIGITRDGNGIGAALAAMLAHTKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9Y6</accession>
    <name>A0A8H7U9Y6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bms1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_001415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9Y6"/>
    <dbReference type="OrthoDB" id="119302at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="6">
        <location>
            <begin position="82"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="311"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="399"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2171939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="797" mass="91632" checksum="E67D431113B0421B" modified="2022-01-19" version="1">MESTRHRAGGLKQSNKPFKSKHSSKGTLKEKSKGKINRVSIKQRGQGPSNKADRRHAARVAQQKKRQEVYETTRVFEGKDGAPKIVAVVPLCDDIDMDLALRNLYQSVEQSVPQGPGPLWMQTERFKHKFQFMPLQRNFIDIMDAMKVADFALFLMSAEVEVDKFGINCLLGVLNQGLVSPIPVVQHLEKTAPKLRTNIKKSLVSFVQQFYPEESRIHTLDNESDAMTVLRMIATQRPRAINWREQHPYLLAENVEFEEHEGEMGTLKVTGVARGAPFNANRLVHLQNYGDFQIDKILSAPLATATRMSDMQEDAAVLDEPKSEDQDDLVSENEPDFMENEQTWPTEEELAEAEERVRHMNGNSNDGSKVTKRVPKGTSVYQAAWIVDEEDAEYSDIDDEDDENMMEDDDEDVEPAGADTEFPSFDDDDEYENLDMNGKENEEEDEFDAVEEDRQLQEYLARQKELKTHTDFPDEIDTPLDIPARTRFARYRGLQSFRTSPWDPYENLPIDYSRIFQYENYNRTKNRVLTQNLVGNVKAKTRVTLYIKDVPKEAYESYSPSRPFVVFGLLQYEHKMTVLNLQITRDNAYEEPVRSKDPMILHMGYRRMVVRPIYSQRGNGKGSNNVHKFERFLQMGKPAVATIYAPTVFGKVPCLLYKENEDDINDPTLVSVGSFMDTDTKRIVAKRIVLSGHPYKIHKRSAVIRFMFFNSEDVHWFKPVQITTKYGRTGHIRESLGTHGYMKVMFDGPITQQDTVMLYLYKRVFPKWNTKLWKGGLNATIVQGGAQKSMDVDAMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UA75</accession>
    <name>A0A8H7UA75_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_003309</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UA75"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000095">
        <property type="entry name" value="Triglyceride lipase-cholesterol esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="12">
        <location>
            <begin position="102"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2178056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="444" mass="50172" checksum="6B973687AFDA005C" modified="2022-01-19" version="1">MARFWGYDYVEQHTVPTQDRYLLCLFRIPFGKREGGSKMKLGKRRSRSRSRSSSVIASTAVVDNVDQFATSSEPATNGFPSISSRFSHKESTVRKRGWNGKPVVLLNHGFLMSSEIWLCNLKESQNLPFLLAEQGCDVWFANARGNKYSQQHMSKNPKDQPFWDFSLNEMAMYDLPDVVDYILEMTGAPSLTYIGFSQGTAQAFAGLSINPKLNDKVNLFIALAPATTPSGLHSQVIDAFVKATPNVIYLLFGRKCPLKIALFWKQICSPPIYVKLIDSCCNFLFGWTGRNMTDAQKLVSYQHLYSPTSVKCLVHWFQIIRTGTFQMYDEMPSLLPFHSSSEASDHVPPRFPTKQIKTPIAIFYGGSDSLVNFEVLSGDLPDLAYVKYIAEWEHLDFLWAEGVELHVWPDVIKLVSNFNPGHFATENGADVFAEAHRFENKVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAD2</accession>
    <name>A0A8H7UAD2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAD2"/>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF402">
        <property type="entry name" value="MIP16918P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="442"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="804"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1013" mass="114549" checksum="73B4E644D19904E6" modified="2022-01-19" version="1">MSSPQDQQSASKGHKEKNSASSRGSLSQRRTERGVDVPVSFSNLRRQSTVSIGDAYSFENYAFGGVSPVMGNSFSTISEDRAYFVPSPYDQRNEYLSRNPSLRSPYEREQRSKRWNRQSDYRYKDGVQEYQETGNQRDTETEESDIEMPDDELTGMSPVETNPHLSRSPNSSKPLSSQPPPQLPFIKPETFSLSFNESLNSKFSEGNAANTPLNSAHTPPSAGPEMSKLWLKSLQQPETIDPLSRWNSRNDSSVSESPVSQASPKWLKDDDALAKMKNITSGLRDQSLGQQSDSNKAQRNVDSFFNMAKAVTSNPQPTMPITAAISRPRSFLLQSAVFQVINSNTVKDRYLFLFNDLLFIAKPIMDESIMGGHPPTNARTMSEDSLTGVKFGDGHKHRFRPNENSLFQVKNIVELSKVTLYVTRDYEAEPIHLKTNADGQVILPPPRKIHPILASALRKFESDPDRAIAYLMEKKILDNDPMAIANFLFKTADLNRRQLGRYISNPDNSNVFHAFLDCFRLQGIRLDEALRTFLITFRLPSKYDSLTYIISTFAKKWYDTNQNVVKFHEDMIVKVIFAMLKLNSAIWHDMDADQDVFTFATERREQRQEKGANAAEQIDSKQKQLADHIPTKSEFMERWSMFDQYNLVPKEFMFDMYDSIREEKLETGWDHKYQIQPQDAAGQQESELIISVLPHRLPTRLTKGIPSPTITIYIPEPDPGLQIKLRGQDLVCEPSVLDFTHSRVQNFTITGSTLGRTSLMFVKVGARAGRYVSPALPRTKAIVVERSFMRHTFQIGFYQTDVKDPPFDAHRSRNNLQPPTHHGNQDIGDDQENDHSINVHTREVQRTKRKYMFSVESEESLRDWVSQLQQFCGHVNREGHHQISSKDTAVKTPEELVALQVLKEALLADEAKRSLIGLRSITKDKRASLLSVHTGDGILPTSEVGSPEDVNNGRPQFLKQANLLSPEGSGKSLSAAAAANVVAKRGHEIVKLGVQNSLMPTMLNFLRHGLEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UB27</accession>
    <name>A0A8H7UB27_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_001850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UB27"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051434">
        <property type="entry name" value="DnaJ_C_subfamily_member5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019396">
        <property type="entry name" value="TM_Fragile-X-F-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027:SF7">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10269">
        <property type="entry name" value="Tmemb_185A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="7"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2179001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="445" mass="51094" checksum="EB22873E3AFA2005" modified="2022-01-19" version="1">MDHNTTALYDTLGISKSATPEEVKKAYRRLALRYHPDKNPDSAEQFKDISHAYEVLSDEKKRKVYDRYGELGLNMMGTVASPLFDPEIESMLCTLFMTLATTFALLIIFFVFLSVKIDNYVSWTWAVVWIPLWICSAVAILSFFTHLLRSFKEDDEGKYDEEEEEADYGHEDETDEERTNRRAARRRQKRRLSQARSTLSLVYLFLVLLFQIFIVMRLDDQVSWSAGTVFVPYFILEIFNFLFTLVDFAINFKVISMAAENHKLGWKQLAQLVFDSFWWFVIRLIQAILIVVRIDGATTCSWGAIFIPLYLIFFKYAIQLGLAYRKFQYIPQQEIAQQGKTTVKLGFIALLIVSILFYSLVGLIARRLDGLSFVKMSDVLIPVFLVLSLVLCCTGCCLPCILMMSSVGDLNDDSEGQLIDPNKRITQYGDSDTTPLQGQSEMTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UB34</accession>
    <name>A0A8H7UB34_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_005579</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UB34"/>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="8">
        <location>
            <begin position="117"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2176345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="353" mass="40493" checksum="372ED119660648E9" modified="2022-01-19" version="1">MAAATHRPSAKKRERKLAVKPIEKQSSLASLIIAHEIDVPGAILVAILVASAMGSTTATKMVKLSYETSPGSNLYDKGWDDAYFVGFWVLAFTFLRAAVMRYVFTPFAKAYGADTPAKQLRFAEQGWSFAFYSIFWSLGMYVMYNSPHWFNPAEYWVGYPHILISGWMKWYYLAQIGFWIQQFYVLHIEKRRKDHYAMLSHHVITFALLVSSYCVNFTRIGNAVLCCMDFADILLPLAKILNYLNLRTICDIAFGLFAVGWLVTRHILFTIIIWSTAFDPPKYMDMLWEPEKGKYFTPTTQKIYLGLFLLLDLIILFWFAMILRVIIKVLTGNAASDTRSDSEDSGDEDDKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UB84</accession>
    <name>A0A8H7UB84_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="17">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">INT43_002031</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 17">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 17">Membrane</location>
            <topology evidence="1 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="17"/>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000014">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF174">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1047"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1094"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1153"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1186"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1227"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="93"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="19">
        <location>
            <begin position="197"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="21">
        <location>
            <begin position="983"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1294"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1294"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="14">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="621"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="664"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="687"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="763"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="843"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="844"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="845"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="930"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="936"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="957"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="960"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="961"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="961"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAG2179181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1316" mass="149223" checksum="E7F22672C38F6EB0" modified="2022-01-19" version="1" fragment="single">DNDEGLDQIFTPLMTQHPNWSTTFSDIQPTPQNMEKPSNKNKKTTQKTKNIKESLIDLLSRLLRRNRRNQDVRNRTIRISPEQPLPHIDPAINRPFIPNSITTTRYTLIDFLPKQLYAQFSKVANLYFLFVAILQMVPGWSPTGQFTTILPLAIFTSIAMAREGYDDLRRKRADQIENNATAQVLRVHRSVDHTTAVWQDIAWKDVHVGDLLRIQQNDWIPADCILIYSPNEEACGYVETAALDGESNLKKRHCVVSDGRFSTPEALARLAATISTELPNADLNNFNGHIEIDQDAAYPLTMENLFLRGTVLRNTPFVYGMVVFTGEESKIRMNLSRNVPTKAPSLQQRVNRVVIAIFIFVIALASICAALAFRWEANNKAATWYLSHSIDQARVVFQFIILFNTMIPISLYADDLKITMEMIKLVQAWLISNDVDMYYEETDTPPTAHTSTINEELGQVNFVFSDKTGTLTENLMVFRKLSCGGWAYLHDLDLIEKQSREGAVIQEIAQQVHRSATRISRNSLTQSLRRSMHNMIDQSSPQDEIEETMLLSELNSAPRLKVDSDIPKTTDLIQSIIKSPQEPLQRRLQFFLLAVALCHTVIPQVDQETGQINYQGASPDEFALVNAAKEMGYVVIERSARHVVLKKPRSVEPIRFEILNILEFSSKRKRMSIIIRLPDNRIVLFCKGADSIVLERSHIPAELVSPISPKEIKRAPWHAATTASSITADFDECNFTDISVEEERWEYARTIHHIQQFATEGLRTLLYAHRFMTQKEYDDWSLEYTKASLSIDDRQEKLFDAAEKIEVGLRITGATAIEDKLQEGVADTIDRIRRAGMRMWMLTGDKRETAINIGYSCRLIHNSSRLIYLEAGPQLESVMLQALQDVQTGQAANAVLIMDGITLSTIETDKEMLLLFCQLGCLCQSVICCRFSPAQKALVVKATRVAAPRAVTLAIGDGANDCAMIQEAHVGIGITGKEGMQAARASDYSMGQFRFLCKLLLVHGHWSYIRVSKFTLGTFFKCMTFYLTQGIFQLWTGFSGTSLYESWSLSFYNTLFSSLPVMMIGVFERDFRASTLIANPELYKIGQRSGAFNFVIFAKWVLSAWWYAACIVLIPLALNGTLFVPYDRHGHSALPPNEARLASLALFDGNFQLFSFGVMLYAITVVIVTLKVAYLECHTQTIITHLVAWAEIGCFVLYNLIYSYAYPASKSYDYAVRGEFVRLLKTPVFWLIIIFTVTIAIGPSVVGKAISDWVWPTEEVHFQELEKDDRISQLWEAEAKRQIVGVEKKTIVNNNAPTTSQRPSSRWQKLQFKRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBL1</accession>
    <name>A0A8H7UBL1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Peroxin-10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">INT43_001229</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBL1"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16527">
        <property type="entry name" value="RING-HC_PEX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF0">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="22">
        <location>
            <begin position="317"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAG2175582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="369" mass="42609" checksum="B883A70103DFCBA6" modified="2022-01-19" version="1">MSATNSSSSNPPTLDSSAAVSNVGATESRSRAAAPTMQLQFPPGAPPDIIRANQKDVYYQNTLQEQMTEVAQRFLGTRRQHQYQKEINVFSDFCYYGLTTILGSQTLGEEYCDIAQINVHSNTYPGMIRRMALVFCHVLLPYFYGRGFMEFRKRNRHQTRERKQSDNKLLNSLQTFAAKHMENIQDFFKKYVHMGHLAIFYFVGSYYSMSKRITGIRYIFTRRLETHEERAGYEVLGLLISLQLFIQGFISLRRYIEERQELAKLQSSAVEEKEHEVNVVEEKKVVDEDDYSFMFDDEASSESEEELSYEQMQALKCALCLEPRKVTTATPCGHLFCWDCVVEWCHNKSECPLCRSSVNVSHLIPLANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBT4</accession>
    <name>A0A8H7UBT4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_007797</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Fanconi anemia protein FANCD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBT4"/>
    <dbReference type="OrthoDB" id="27031at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029448">
        <property type="entry name" value="FANCD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32086">
        <property type="entry name" value="FANCONI ANEMIA GROUP D2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32086:SF0">
        <property type="entry name" value="FANCONI ANEMIA GROUP D2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14631">
        <property type="entry name" value="FancD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2177140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="156" mass="17410" checksum="653F976F41C5C9D8" modified="2022-01-19" version="1" fragment="single">GLVACLTTIMQNDQDLIASILEALSNFSLQPEDLDDIRETMINQLDSANMGDLPIIMKFLLQTSTPETIEQIILNIRQKLDFKALAKLQHVQRDVVSFMAANKTSDRGTVPEALVLGNYLITLHKKLFSSATNFAIGSKKILCSDYSFTNSYRMHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBY9</accession>
    <name>A0A8H7UBY9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Splicing factor 3A subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_007962</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBY9"/>
    <dbReference type="OrthoDB" id="447637at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01800">
        <property type="entry name" value="Ubl_SF3a120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000002">
        <property type="entry name" value="Splicing factor 3A subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000001">
        <property type="entry name" value="Splicing factor 3a, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045146">
        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022030">
        <property type="entry name" value="SF3A1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035563">
        <property type="entry name" value="SF3As1_ubi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF1">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12230">
        <property type="entry name" value="PRP21_like_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SURP motif" evidence="9">
        <location>
            <begin position="49"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="9">
        <location>
            <begin position="147"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="643"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="517"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2177305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="729" mass="81545" checksum="3C2BD32393DACA66" modified="2022-01-19" version="1">MVATTVSDPTASLSNGTDAMDVDQNGTQGTDQEAPITGVIYPPPEVRKIVDKTADFVARKGQILEERIRENERHNPRFSFLNSKDPYHAYYQLRITQTKEGKTTKVAAKPQEKSEEIQEPIQQAPKEPSKFEFSSDMPAMSAQDLEIIKHTAQFVARNGSRFMSQLAQRESRNYQFDFLRPSHSMFNYFTSLVTQYTQLFVPPRDIKDRLKKNVDDKYDVLDRVKARVEWIAWVEAEKQKKQDEDEKERGMFYELRQDVAKLDFFINNFSLAAYAAIDWHDFVIVETVEFTQDDEHLNLPPPMSLSELENMSLEQKRLTAMAESTQPMEQDTQQNDEMEIEDVDMDNDDEEMPQQAAVQDIKIADTTGPIKIRTDYKPKVGATTRQINEPTQLCPRCGQAIPMSEMDEHMRIELLDSKWKENKQAAEAKLRDSNLLQEGTDVAKILKNFSGYRSDIFGSEETQIGKKIETEAALAREKEKMTWDGHTATINLTSQRATQGATIEEQIAAIHRAKGLTADGGSSIGPQVGDKGVASGSAMTGASITREPQPASNNYQPPPSMPQQSYSQYPPLPGQAPVPNPGLFANQIPGYGMPGAPAPAMPEEAGLTRKAEDETEAPGAKKPRHDGPPMSEEEWMAHHPDPIYLTVQTPTLPDFKLTGETITIEDLPLTTLVSTLKNRIADKVGMPYGKQKLSVSSTGTVMNNSKSLAFYNFEQGSVVVLGLKDKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCD6</accession>
    <name>A0A8H7UCD6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exportin-7/Ran-binding protein 17 TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_005611</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCD6"/>
    <dbReference type="OrthoDB" id="244158at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057947">
        <property type="entry name" value="TPR_XPO7/RBP17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044189">
        <property type="entry name" value="XPO4/7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596">
        <property type="entry name" value="EXPORTIN 4,7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596:SF2">
        <property type="entry name" value="EXPORTIN-7 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25795">
        <property type="entry name" value="TPR_XPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exportin-7/Ran-binding protein 17 TPR repeats" evidence="8">
        <location>
            <begin position="446"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2176377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1112" mass="127336" checksum="1783B24568D324DA" modified="2022-01-19" version="1">MSQEDQQRILYYTNLCETLYGPASQQDRERAEHILEHAFPTFSDAAGSGVAGRRPSLDSSYAYDISSPQDSAYALTVLLKNSPNPYVQMFASSRLKALITDQFPVFSQDAKIQSRNFILEYTYMHPNLQPFVIIQLAQVLAMLTKLGWFDLDEFKNVHGDLNQFLQASVDHRIVGLQMLTVLVQDINLPIPTRNLARHRKTAVAFRDEQLLLIFETANTILQELLQNNISMDNGQRDRLCDAVLKLISKCMAFDFIGTTPDESGEDSGTIQIPTSWKSMIEDESFIRNMFSAYETFPSPHSAQAMECLAQIATIRRSIYSEDERHKVILRMMQGTRDIMVSSAGLSDESNHHHFCRLLARFRATYQLHEITEKEIYEEWITMVADFTVKAFQAWQYSPNSVTYLLSFWSKIVQSLSYSRASVAVGKIENLTIELVRSYISSRIDSVKTIVEEMLDDPLDNEDALMENLDMLANIARCKYQEAASTVITIFEPIAASYEDLVSRINNAGEDMEELKQAILVTQTKFAWIVYIIGSFLGARTTYLSSEELDDIDGLLTTKVIQLINVSNLVQSQHGGALAYARLDSAFIFALQQFRKAYIGEAGSRTAVYNKLNEVFGIGDQTGMLDLSTQKIVNILQFWSTDERVVWHALKLFSELASGYSSSKHMRKLDSVQMVMMNHSSDQFGFRSNPNGKANRALYYTALSKILFSEDCSTKTFLDFMKPFEVQFQNLLSLNSVEDYRQESVKTSLLGLFKDLQGFLIPIQSRVNFTMFFEWFYPDYVQVVHKALQSWGNDTLATSLLKFYSEFVYNRSQRLTFEVASANGILLFRETSRVLITYAQSIVKYEIQDPSQKYAYKYKGITACFEIMTRSYAGKYISFGVFELYQDKALDNALNAIFQMILDIPLDDMMAFPKLTKAYFSFLDTFTDGHMMRLSDMDSDAFLYMMRALGTGVKSLEPSVCSQACAAIDHLCTFVVKETERQNSKPTKTHWLLLYLSQYTDILPFLFTTVFNVVLFEDKPIQWSLSRPLLGLILLHKEYMMEYVNNVINHQLPERREFLSLSIQSLMNGVEWNLTHRNRERFTQNLSAFRREMNTNSISLVPISADYGMDAMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCT8</accession>
    <name>A0A8H7UCT8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">anthranilate synthase</fullName>
            <ecNumber evidence="2">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_005896</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCT8"/>
    <dbReference type="OrthoDB" id="64220at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF4">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="5">
        <location>
            <begin position="11"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2174834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="157" mass="17702" checksum="C722048268231753" modified="2022-01-19" version="1" fragment="single">MSRNQAGIRTLIIDNYDSYTFNLLQLCPDPSNVVIIRNDQFTWLHFVTNVLPYFDNIIISPGPGRPEHANDFGICTQLLQGQREGSEALQIPIFGVCLGHQGIALIFGGKVKHAKRIMHGRMSQIVREDPYANGDVLDNLPLPFWAVRYHSLVADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDA4</accession>
    <name>A0A8H7UDA4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_008984</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDA4"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="36"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2181401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="424" mass="46836" checksum="EFD12785E1A7988B" modified="2022-01-19" version="1">MYHSNASEETLHEPHVIIDEKEEECPLVPPDGGWEAWRVTLGASLIMLIQMGFVSSYGTLEAYYVEVKLNDKTESEISWIGSVQVFFTYFLGLFCGKIFDSYGTRWTLLTGTILFPFSLLLLSFSTQYWQMMLTQGILLGIASGCLFHPSMIVVSHWFNSKRALATGITTAGTAIGTQLRYIIVVLTGFEWAMRVISFISLAVLLVCNLLVKPFYPPKKSPLLNGLFEGFKDFKLCLLIASSCLIYFGFFIPNFYLTVYAESIGMDENLSYYCLTFLNIGSLLGRISIPYAADKLGRFNLTAASALVTVVSIFGLWLGCPNTAGVLAFSVMYGIFGTPSMALVSACCAEISEKHQVGTRNGLLRFTMSFPILAGPPLAGELVRVTKVASGYQNLIILTGLSWLAGSVLLVYCRLMVSKSLKRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDN5</accession>
    <name>A0A8H7UDN5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDN5"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020448">
        <property type="entry name" value="Maltose_ferment_reg_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00054">
        <property type="entry name" value="FUNGALZNCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="124" mass="13993" checksum="B8B2C473BD3762F0" modified="2022-01-19" version="1">MEKASLSPSPVETPARQKPSGTKRIKISRACDECRKRKVKCDGAQPCYRCRKSDTLCVFAKVAPRRGPPKQYVELLETRLRMVEKALSLLEKSNLDQSTANVDEEPQASWDQPRYGKLASHSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDU5</accession>
    <name>A0A8H7UDU5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="7">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_006942</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="7"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDU5"/>
    <dbReference type="OrthoDB" id="10250191at2759"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09135">
        <property type="entry name" value="PLDc_PGS1_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000850">
        <property type="entry name" value="Phospholipase_D_PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2182016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="503" mass="57689" checksum="B55437C8B8BB0AEF" modified="2022-01-19" version="1" fragment="single">RVNLELVRKTYYVRARLVHAESQAAVLSRFTPLQQLAPSFNLNGAQISPLNEPAEFYTSLKEHILSAKQRIFIAALYIGSSEQELVDTIDTALSRSNHLKVHLLIDCLRGTRASKQQSSATLLLPLVQKYPNQVQVSLYHTPDLNGILKKALPQRFNEGIGLMHLKVYGFDNNVILSGANLSTDYFTNRQDRYIKFGDTKDLSNYYCDMLKTVGSFSYTLQPPVAHTESSAPYGLLLKDTADPVENSSEFKTQACQRIQEFLSRHQSASGKSDGDHDTVVYPIVQMAPLGIRQDERATLRVLDIIYEHGESVTSKDYWQVYLTSGYFNFTQRYKEMILRTAAKFEFLTASPKTEANWINQQANGFFNSKGISKYLPPAYTLIERKFYREVKRLKKESLITIKEFERPDWTYHAKGLWLYQQGEKYPVMTMIGSPNFGYRSNERDLEAQAIVVTSNAKLRQAIHNELELLREQCEPVTDETFKRKERYVPYGVRIATSFIRSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEX8</accession>
    <name>A0A8H7UEX8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_007528</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEX8"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000065">
        <property type="entry name" value="[Pyruvate dehydrogenase (Acetyl-transferring)] kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="288"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2176874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="425" mass="48820" checksum="FD614A62514F1A1E" modified="2022-01-19" version="1">MYKITPQLYEKIKHFAKFPQTGVSLRQMVMFGQTPSQGTLLKASQFIHEELPIRLAHRVKELEELPNQLSDMPSIIKVKNWYAQSFQELIEMPPPELSSSVRDRLRKSVAEGNSNHLPHNQPNLAMLEQNGGASRKPNVPLGHRYYFKDIAEFDWPPEVLRYNESFVKRIEAIKRRHDPVVTTVAQGIIEYKQHRRSANIDTAVQEFLDRFYMSRIGIRMLIGQHSALFRGPPRKDYVGVICTKTNIAEIAQEAIENARFICEDYYGLFKAPEVHLHCPEEVEFMYVPSHLSHMLFELLKNSLRAVVETYGDDYEHEYPTVKIIVAQGKEDITIKVSDEGGGIPRSGIPLVWTYMYTTAEAQQLEPEFNKSDFKAPMAGFGYGLPISRLYARYFGGDLKLISMEGYGTDVYLHLNRLSNSDEPLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEY5</accession>
    <name>A0A8H7UEY5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_006235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEY5"/>
    <dbReference type="OrthoDB" id="10264376at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="158"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="259"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="309"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="368"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="525"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="596"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2183231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="623" mass="69988" checksum="1BD71F6F881766EC" modified="2022-01-19" version="1">MDCFSRLSDLQDQFWHLGTGQHIVVSNMSWNDDLSGMLPTSFGKKAKSAPKPQASASNDTDWDALRSFMPMSFGKQEKKKDTSTIFEKTKREDFQVEEASRKRQKHDDDGTKEALNNSEAMNNVSDSDDDSDDDSDDDDFEDGVEEEQELPISHEIRLKDHHRTVSALSLEPSGSRLISGSYDYDVKFWDFAGMDASYRPFRSIEPCGSHKIHDLHYSNSGDSFLIISGAARAKLFDRDGYEITEYAKGDPYIRDLRKTDGHISGLTSGAWHPYDRNTFITAAQDSTIRIWDVENKRKQKEVILYKSKERGGRAIVTTTAYSKDGKMIVGACQDGTLNVWSSTGPHVRPTHTLDNAHTVGTETSSAVFSMDNHTLVTRGGDDTVKVWDLRNFKKPVSVANDLATINPETNVIFSPDEKLILTGTAAKKGEGYGKLVMMDRNTLEVRRTMSITQASVVRVLWHSRINQIITGSADGNIGVYYSPNTSVRGAKLSVVREPKKRAVDDYEIDRPILTPHALPMFKEETARKTKRQMEKLRKDPIASRRPDMPMSGPGRGGRVGTNTQQAVIKSLSKDTTRDEDPREALLKYASMAEDDPQWVGSAYKKTQPKAVFQQEEEEEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UF70</accession>
    <name>A0A8H7UF70_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UF70"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2183516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="25950" checksum="7A8099D56C9F8DD2" modified="2022-01-19" version="1">MDSLALASLEYLLKQPINSKITLLVVDILRTAIRCTSNNIDNSLSRRKTSPLSEVLKQLDAPYVPPLNIYVKDLIRRSNVSTGTVIVSLVYIARLQKKLPEATQAKTLNDSSPKNRHWARYASCFPLAEDYDLSVTEDDLLQVCSPLIDAHIPLSMPLTPPLMPSVKSVDEDHIIEGYLRDNMEISDDSAYSSDSELTPRSIMSLNSISPASGKSLDCPGFDSSLPERWETIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFL6</accession>
    <name>A0A8H7UFL6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFL6"/>
    <dbReference type="OrthoDB" id="276515at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09083">
        <property type="entry name" value="EEP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF36">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2178088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="348" mass="39123" checksum="CE67946C32310AEB" modified="2022-01-19" version="1">MATLKVMTFNVRIDGPQTDDLPPVESATQTLGGEQRWALRKWKVADTVLTFEPDVVGLQEPYHNQVLDLADLLKSEYDWIGCGRNDGKEEGEYSPIFYKRDVVELESNKTIWLSKTPDQPGSKDWDANQTRIASFATFKIKGNEGKKFQVINTHFDNSGANARRESAIILLKELAAIFDPVVLMGDLNSTEDDGAYLELTCGRYTEKKHDTASQLIKLNDNHTVEEAKQAAAPVRTGEGHITLPTHIQFRRGKLDPAHLKPLNERHGFTDARYELESRQDGYHGLSGPYGHYLTFTGFGNPGEDPPSRLDYILLANNVKATRYAVLENKYEDGLLISDHRPVMATVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHC4</accession>
    <name>A0A8H7UHC4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHC4"/>
    <dbReference type="OrthoDB" id="21648at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021900">
        <property type="entry name" value="DUF3512"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12024">
        <property type="entry name" value="DUF3512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2185841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="464" mass="52353" checksum="6B8396D145167C65" modified="2022-01-19" version="1">MPVTSRHQAKRSEEGRDKATDRPDAPKAKNGSLPEQDWESVSDGDLNKCLHRITFILQSYDGKNILSQSQSSDISLYQILSKINAREYSAIADYQHDIQELFRNSYKKSDNQTNETLSALYKMAEQLIRIERTRINRVKMDEMNGDNPVNNSSQSADDDVTMEETNEENAVEVNGKMPKVTPLTEQVQKALYQVTPDGYVFSDMSSIPHWVGEKGDTQELPTNYHEVIIHPVTTTDQDVASLKQAVPNHIEMHRRSDRYEHRMVPVEMLDFGAFASFAPNYDSNSANISFESTYLARITKQAEREAEKRRTQELYGDSAIDTTWLKNQGLDAEAILESVNGSEPNESEEKKDMSSVIEQNAHLLKRLADLQDERFSQRNPANKPVGKEELRIANILQQRLQEAVGQVTPSDLVHADAIENAMQRMPAKHAVYRGTLPPTKLFAFPAGDSGVMLQTSSQPNIGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHC9</accession>
    <name>A0A8H7UHC9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP-binding protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_002294</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHC9"/>
    <dbReference type="OrthoDB" id="391988at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00321">
        <property type="entry name" value="GTPase_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052279">
        <property type="entry name" value="EngB_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03598">
        <property type="entry name" value="GTPase_YsxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46498">
        <property type="entry name" value="GTP-BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46498:SF1">
        <property type="entry name" value="GTP-BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EngB-type G" evidence="8">
        <location>
            <begin position="50"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2185856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="240" mass="27038" checksum="D917E1526B18649B" modified="2022-01-19" version="1">MLYLAKRCYSAFPRIERPTLEQIQFANRIFQQPATFVKSIAQPDQAPNTTYPEVAFVGRSNVGKSTLINKLLNRKGLVKTSSKPGHTRLVNFFSIGDKMHLVDMPGYGYRSREEWGDSIMGYLTSREQLKRTFVLIDSTVGLKAADLQLFEFFDKFAISYQVILTKRDRISEKKFQENKEALEASVFQNAVCCYPQLLASGQQRKSRRAASQAAAIDEGIQDIRWAIVNAAGLCKPPSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHM4</accession>
    <name>A0A8H7UHM4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_003977</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHM4"/>
    <dbReference type="OrthoDB" id="19679at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019148">
        <property type="entry name" value="Nuclear_protein_DGCR14_ESS-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940">
        <property type="entry name" value="ES-2 PROTEIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940:SF0">
        <property type="entry name" value="SPLICING FACTOR ESS-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09751">
        <property type="entry name" value="Es2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="400"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="439"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2180188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="454" mass="50681" checksum="9BC7AB39B2B0E5C6" modified="2022-01-19" version="1">MSKELTIRNQNKAIALKQQQTVVPNRPAIVLDEDTYTDAISYIIERDFFPNLAKLRAQQEYFDAEDSGDLMRMQHAGKELRRLATTPRRSRPRKYSFIPLLTRSTFELLSLTHIWSPDTRSSTAKAQAAVPSRPAGIDQDVDIDLNLDQFQARYTSEDNSSFVDLLGKANEQRKEKHKWVWDMESNQLRIKEAPHVESALTIVDERDALPGTWKYKARNALMYMPDVDNVKNKSTVNPDDGRGSPKAVVHSNTQFSAQDLGVLNVQKSKSVKDAESGKMTPWNKLAGDDEDSDLPEFAGYNLVPETPSINPSNMNTPLMTWGEIEGTPLLITGSETPGPNNFRLPQPSRREELGHKLSERASKSYRTRMSNKQANKITKGGLTPKFGSGIMSPAAQHLLRKSDRRTPSFNDSLRASYGSGSVTPGHARSQATPTPLFRAGATPTPTFATPTKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJ81</accession>
    <name>A0A8H7UJ81_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Cytochrome c oxidase subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_006753</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJ81"/>
    <dbReference type="OrthoDB" id="5778907at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2183742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="138" mass="15579" checksum="C81A7ABC67703BAD" modified="2022-01-19" version="1">MLRVALTGAISRATARSAVVAAPRTAVVAQRFYSSGHEEESYESFSERYVKFFDGVDDLFELQRGLNNCFAYDLVPSVAVVEAALKAARRVNDYPTSVRIFEGIQDKVENKTQYQQYLDELEPIRKELGIETKTELGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJT3</accession>
    <name>A0A8H7UJT3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJT3"/>
    <dbReference type="OrthoDB" id="2278325at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2182393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="498" mass="54742" checksum="00A53A5CAC48D9EB" modified="2022-01-19" version="1">MSRNQAAASQMVGSFPPAVRVTNTSQRRPVIATATNRSNQPVPLRDRIVQNQPKDKLLEYIHHFVEGKKASDAHDILDNLIKSLNNEDEEIQELPQDDEILLANPETVPILPKTRQVAQASVAELATLRMPATLKLPAPTASSATAAAQPMFANVVPAAPVVDLSFLRQLQQQATVTQTVYVRAGTTTITATVSATGSSDSNGSQKGNRYMDEGGGRESPVPVIAMLAVFGAILVIGPLIAYCWWRSRKRAQKENTLPYFGRDMEARHRYPPEVGGYSSYHSFNPGVITEIRDSPQRHMAADAFEASSSRQPSAAPSVTRKQSKFKGKAHKLPPINTSGVSSSEPPISPTFVPLPGTPMKLVPREQVLSDPQRRRGVDALDLAAQRESNYKHWKAIKSDDNTNSISQPKSAEIPTEVGQQHKKTKEYVKKLVDESRNHPEKPSSISKNLAELQRNTKSALQPQPIELEDIPFTSHHYPDRNDSPSDVSTARLMLQSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7ULC3</accession>
    <name>A0A8H7ULC3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homologous-pairing protein 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_002445</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HOP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7ULC3"/>
    <dbReference type="OrthoDB" id="272266at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120231">
        <property type="term" value="C:DNA recombinase auxiliary factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120230">
        <property type="term" value="F:recombinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010774">
        <property type="term" value="P:meiotic strand invasion involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010776">
        <property type="entry name" value="Hop2_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040661">
        <property type="entry name" value="LZ3wCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938:SF0">
        <property type="entry name" value="HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938">
        <property type="entry name" value="TBP-1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18517">
        <property type="entry name" value="LZ3wCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07106">
        <property type="entry name" value="WHD_TBPIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous-pairing protein 2 winged helix" evidence="9">
        <location>
            <begin position="15"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine zipper with capping helix" evidence="10">
        <location>
            <begin position="138"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2186007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="200" mass="22521" checksum="52BA7B6AA4917761" modified="2022-01-19" version="1">MTKAKKSTSVQDKDADIHTNLNNTLTKTSVAKALDKLTDKQLAFSKTYGKSIIYSVAQDENNVVTPDEMAKLDSQMEKLSQKLSSLKEAKVEKVNELKSLNSTLPTLEAQSLLTQLKVQNHEAAQRLASCQTQNGQISVHDKQRIEKEYDTNINLWKSRKKLFNEIFKTVTEHLPGKVSDFKDEIGIEEDPQSLESVLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7ULR2</accession>
    <name>A0A8H7ULR2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7ULR2"/>
    <dbReference type="OrthoDB" id="5382203at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="835"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="541"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="701"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1022" mass="111116" checksum="D381B99B404BF3B1" modified="2022-01-19" version="1">MPANSPYNGKEYVSIQAASAIIAEVAPLRISSDALVALNQFLDEFLIMLLVQAQCLDLAQFKSAVAHTLSYSSLGKNAIVEAELELKSYLAIAEVDAELDVYERMRSQKFGPILLLNDVVQQIRHRTDEFGALVAPQAKMLSTPPKPGAIVSSIVAMYLTAIVEHIAEYVLLGVARTCEAEDMSHVRIKEVYSTLLEDTQVGSAFSSMDLKTRLEKRLNSNGQNGYVPGSPMTPTKYSVPMSPTSVNSDMSGVEGLGKNSGEYELNGDQLSIRSEPFMPRTEQPQRPSSRASQNSKSLPSMGKSNTYRPTSVLNQSSVNGGAGTPPSPKAKTGFRLFGKKKKAPKDMENGDIFARAASPSTENDSDDTKTMDFEELMMSGGTMKVTLTPNRLKSIEVNEKAVQQEKLQNTWRQKKPDNIEIVPPKTDTLKRTALQNLAQNNRSSIDSNASNSSASYRSPPPVPVRKAKRWPDAPAVPPLPASMRNNAILSQKNTPNQPSSPVPSAAPGSPTLSTRSMRTINSVTSLQSESDGEEPNRRDSLMSQSSTFSSIIKSAPAPPPNGTMSKPSTEPYRVDSQKSYSSDGKMETESSTSPNFTVSDNKTAVNRRTSMVIAPRPPRLARIQPRQHSSLVISTTGAEETAPIQSEQSISTEVSVSSQEAVPTTMAIETPILFQTVTSPEPVVPSPAAIPSPSPSPAPNPAQIAAQSATAASPEAINGEEEEEEYEDDDEEEDDSKEQTVSAFKATAHRTILGSVSGDSLSNNTSNRPTAKNWKRVTIVNSPSFPAIKDDGVKISTEDLLSLHSKMASSESVKAVMSLFEAFLAEHNVAHDKVDAGSRTPAEQASKKEAATATVTGEEAKPLANDSSVQTEPWAPTCEHLEKPLPPPKFESISEDKLESLLISDPADYIPVRVAPIITVTDCDETDAEERPLDLTEFDVDSSDEYSDVDDAIPMSRFSYPPEYRKAQYMDTKQVYESEDEEWYLDDSDNEFEQEDVPVPVHPEILEEKMAAEWLIGSDSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UP79</accession>
    <name>A0A8H7UP79_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_002447</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UP79"/>
    <dbReference type="OrthoDB" id="4966at2759"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00642">
        <property type="entry name" value="GTP_cyclohydro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.286.10:FF:000003">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000012">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006825">
        <property type="entry name" value="PRK09347.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006826">
        <property type="entry name" value="PRK09347.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="11">
        <location>
            <begin position="64"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2186009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="261" mass="29200" checksum="780A3D937791EE93" modified="2022-01-19" version="1">MEPIQPTPTKPLIPGRAITPISRQETPIDVDGLSWPSMFIAFSIGTKSRRDETDAQRGEREEKIAEAVKTILSCLGEDPEREGLLKTPSRYASALMFFTKGYEQSIKVLMRPIATDVLNEAVFEEDHEEMVIVKNVDIFSLCEHHMVPFTGKVSIGYIPNRRVVGLSKLARIAEMFARRLQVQERLTKQIASTLMEVLQPQGVAVVMEASHLCMCMRGVQIADAVIFTSQKPGSSTMTSAMLGVFRNNPKTREEFLSLIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD48</accession>
    <name>A0A8H7PD48_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD48"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="96" mass="10624" checksum="F94BDFCA153BCE47" modified="2022-01-19" version="1">MVPAESSSPEEFEAVDVTGALYSDGDDDVPDEEFLPNDDEDQTNQIYGGYGVHSADPEGTEPKNPPLPTHLQPETQSDFQRGDSNNKMISHPFWDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD68</accession>
    <name>A0A8H7PD68_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008142</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BRX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD68"/>
    <dbReference type="OrthoDB" id="1638493at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000003">
        <property type="entry name" value="Ribosome biogenesis protein BRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026532">
        <property type="entry name" value="BRX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Brix" evidence="7">
        <location>
            <begin position="28"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="258"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2171762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="290" mass="33159" checksum="6BF83613D103BEF2" modified="2022-01-19" version="1">MASVYKSAKAQESEKKANGTVDKRINKQRVLLLSSRGITFRHRHLMNDLETILPHAKKDSKLDSKSHLHILNELAELSNCNNCIFFEVRKRQDLYMWISKTPNGPSAKLHVQNIHTMDELKLTGNSLKGSRHILSFDKNFDSAPHFQLLKEMFTQVYGVPKGSRRSKPFIDHVLSFSIVDNRIWFRNYQVVEKNAANTPGYTAKEKEDMTLVEIGPRFCMTVIRLFEGSFGGSTVFANPEFVSPNMIRAAHRREKATKYNSRLAAQSERKAKLKDAEGKESELSTRKVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDA6</accession>
    <name>A0A8H7PDA6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDA6"/>
    <dbReference type="OrthoDB" id="2157641at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF373">
        <property type="entry name" value="PH AND SEC7 DOMAIN-CONTAINING PROTEIN C11E3.11C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="1">
        <location>
            <begin position="29"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="143" mass="16671" checksum="9FC316A2681F6709" modified="2022-01-19" version="1" fragment="single">MRLDSAFRYLSDALYVNNTNSLTYTTNFIRKLCSKLFLRAEAQVIDRVLEIFARRYWSCNSESLFGSSDVVYAVVYSLLLLNTDLHVAQGSHTRMTRSAFVRNTMMTVRDTRPPVQQDGRAIHQTKVWEDHMETMLRDMYTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDE7</accession>
    <name>A0A8H7PDE7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E2F/DP family winged-helix DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_008222</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the E2F/DP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDE7"/>
    <dbReference type="OrthoDB" id="552115at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000360">
        <property type="entry name" value="Transcription factor Dp-1, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015648">
        <property type="entry name" value="Transcrpt_fac_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="3">
        <location>
            <begin position="270"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2171842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="377" mass="41699" checksum="8B5582A0AF72B4C8" modified="2022-01-19" version="1">MSSPLLLADQHNYYMTHTTPPPKTGNQYASSPLPSPPLSLARSFKPKLPAIFDRSSAGYFFAPYQSLKQSVEPCIDQNEYDGTVNDGFELKPISNIPKAQTQILPSIQQIVTPSNSPSPKSQTSHVLRKRSSNEFHDSSSCTTRSDSPNSRPSSRKGSIASILNVEDCAKYSESTDSTVKSENDIVIQIYVPETQNAGPTAIHAPRGRPPHNISGNRKRRMTTSGFAYNSSTADTIEQQHTPKRYRSETSNSVYVEESSITAPLASQQQQRAVGLRHFSQQVCKKVREKQVTTYNAVADELAADIQTFSDGQYDQKNIRRRVYDALNVLMAMGIIAKDRKEIRWLGLAGIDNPSSKAATEKLSDRVVEETKVLEVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDP1</accession>
    <name>A0A8H7PDP1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_001469</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDP1"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097039">
        <property type="term" value="P:protein linear polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF13">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="81"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="85"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2171992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="50819" checksum="4B90B6D191A7762A" modified="2022-01-19" version="1" fragment="single">WFFPHLDEPSLQLLQKFNILNLLLVYCVPLFYIFYPALLLPAIFFRSLSYLVSRLWAKMSEADVVRDEDTSDYLGDDMNFWLQRCSICLDSKFNLFLDSCRDQFCSDCFARYIEESINSSWGLSVKKIRCPVCQECIPQSEWAKFVSPALVQKYNEFNRPYRPFSRFCQDCDSELVACRQNRVGGLCRESRFQSIRQAIDTALNMCASPCLPPATSTVAMLARFQCDRKNGYSYRNGSVKEMHHYVTSAVLACIESRAQHNCSTCQPLDETTAKNLAADISLQFVSMEISPESWKSLQFAHIAMFPDVECSTCSHSTCLRCGEFSHPDTSCRDNLQRELKNKESSEELESIRWKFDNSRSCPSCSIMIHRDEGCNKVDCSLCGYRFCWACLSAWSEKCGFYQCGFQSDDELAAAVAASDAALEAKAELGVPDVLTIERRYSLTSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDT9</accession>
    <name>A0A8H7PDT9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_001556</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDT9"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="193"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2172079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="533" mass="59919" checksum="71153F183F2063DE" modified="2022-01-19" version="1">MEKTDIVSIEPPSNNPGIGCKEGARSDGYWTLLRDYASSQTVIKLKLVKNSAATGTKRPRLPSSPPLQPIKRIKMMYSTTPEMPSLSTRISTVSYSSFDDRSSSQITSQYSRPTTISTECHPTLPLKKRPRKALSSPKSFQVSIDTLTRLDAILPSAQDRESHQVDDSSYMAYRNILLGALECDKFNLSKPMYDLQGFVGCGASGLVVRAQRNGKTVVIKMIAEVNSSAHSKYHKELDNLARLDHGNIISLQDAFTCPSQDIRMNAQDEPIKTPRIFCLVMPYMEETLFDLLARHREQRTTKLGGLPLDMVQSVFAQIAAGLAHIHTRGMSHNDIKEENTLISLQGDHIFAALCDLGHARMTKTQNEPMLSTTPTHQCDLVDCNYRSETMQDTRLYIIYGTAAMTPPEMQPNYRLRQQVLHSSSGSSNHHEFEKFQGFEADVYALGLVLHSMVFGKLPEECHTWPKTMEALKNVEKKPSAGQCAIHIGGNNQLRCMIPSSLRHLLNGMLHRDHQQRLRMDQILKHPWVRSFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PE47</accession>
    <name>A0A8H7PE47_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BLOC-1-related complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_004813</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BORCS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PE47"/>
    <dbReference type="OrthoDB" id="2379870at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032143">
        <property type="entry name" value="BORCS7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16088">
        <property type="entry name" value="BORCS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0458">Lysosome</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2172272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="133" mass="14850" checksum="816C70D2F9A9B3E8" modified="2022-01-19" version="1">MYRQKSPNSSFSKRLSGNFQAVSLASSLVSPLLATEDSLSFNKQHSTDAAALAIEQLSNCYKGSIRRSEVTEETMRSAKAFTQVDQYLKNTRLCLDKMENTVDKLLKTNDGIAKDLTALDDIQRSLDIDELRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFD3</accession>
    <name>A0A8H7PFD3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">INT43_000225</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFD3"/>
    <dbReference type="OrthoDB" id="1698572at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000059">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000004">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56037">
        <property type="entry name" value="PheT/TilS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="16">
        <location>
            <begin position="294"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2172875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="595" mass="67412" checksum="E7F4F45A3BF36FAB" modified="2022-01-19" version="1">MPTVNVDKELLYKSLGKTYQTEEFRELCFHFGIELEEDTSETVIKDGQSIEKPLLKVDISANRYDLLCQEGIARALRVFLKLGDVPVYRLVKPTAGLEKIVVHPDTAKIRPFVVGAILRNIKFNEDSYNSFIDLQDKLHNNICRKRTLASMGTHDLDTIKGPFTYEALAPKDIKFVPLNQTQEMDGNQLMEFYTADKHLGKFLHIIRDSPVYPVIYDSSKTVCSLPPIINSDHSKITLNTRNVFIEITATDEHKANIVLNTLTTMFSEYCEEPYTIEPVEIHYPDGTVKVTPDIADRRATAKVDYINSCTNLSLSPEEMCDLLKQMSMLATVNPTDKNEIIVEVPPTRSDILHACDIMEDVAIAYGYDNLPKRVPNVNTVAAPFPINKLSDSARRELALAGFTEVAPLTLCSHDENFKFLKRVDDGTTAVKLANPKTIEYEVVRTSLLPGILKTINSNRKHPLPIKIFEVSDITLKDDSYERKSRNERRVCAAYASRTSGFEVVHGLLDRMMKMFNIQFVGRNSNELGYWITEAENDTYFPGRSADIYLTYLVPETHRRTTAKIGSLGVLHPEVLQNFELSYPTTVLEFNLEPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFX3</accession>
    <name>A0A8H7PFX3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Transfer RNA methyltransferase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TRM8</name>
        <name evidence="12" type="ORF">INT43_004590</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10 11">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a complex with TRM82.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="11"/>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFX3"/>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106143">
        <property type="term" value="C:tRNA (m7G46) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000060">
        <property type="entry name" value="tRNA (guanine-N(7)-)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03055">
        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00091">
        <property type="entry name" value="tRNA (guanosine(46)-N7)-methyltransferase TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 11" id="KW-0820">tRNA-binding</keyword>
    <feature type="active site" evidence="11">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="94"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="127"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="225"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2173216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="252" mass="29391" checksum="D09EAC1E01705F38" modified="2022-01-19" version="1">MSTPESGQSESQIKLPQKRYYRQRAHANPFSDHQLKYPPQPSEMDWSKHYPQFYPTKDAKCDKKVEFADIGCGYGGLMIALAPLYPDNLIVGMEIRLKVEEYVYERIKALRAQNPGQYQNVSIMRMNAMKFLPNFFEKGQLTKMFFLFPDPHFKARKHKARIISNTLLAEYAYIMKVGGILYTITDVRDLHEWMVEHLDAHPLFQRISDEECNQDPVTEHVRTATEEGKKVARNEGDKFLACYRRIADPYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PG32</accession>
    <name>A0A8H7PG32_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 6A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_004686</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PG32"/>
    <dbReference type="OrthoDB" id="9443236at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000076">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="209"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2173312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="429" mass="48140" checksum="10E2F28A7D135102" modified="2022-01-19" version="1">MATLEDKSLWENDQNDDLEAEILRLNNEEITNRTRLLENDIKVMRSEHTRLKHEQDSMKEKIRENKEKIKMNKQLPYLVGNVVELLDVDPEDEGEEDGANVDLDSTRKGKCAVIKTSTRQTIFLPLIGLVDADKLSPGDLIGVNKDSYLVLDTLPAEYDSRVKAMEVDEKPTEDYTDVGGLDKQIQELVEAIVLPMTHADRFKNLGIKPPKGVLMYGPPGTGKTLLARACAAQTNSAYLKLAGPQLVQMFIGDGAKLVRDAFNLAKEKSPAIIFIDELDAIGTKRFDSEKSGDREVQRTMLELLNQLDGFSSDDRIKVIAATNRIDILDPALLRSGRLDRKIEFPLPDEEARARIIQIHSRKMNVSGDVNYEELARCCDEFNGAQCKAICVESGMLALRRGAVEVTHEDFMDGIQEVQAKKKMSLQYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PG34</accession>
    <name>A0A8H7PG34_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dynamin-like GTPase MGM1-like lipid interacting stalk domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PG34"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056495">
        <property type="entry name" value="LIS_MGM1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24550">
        <property type="entry name" value="LIS_MGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-like GTPase MGM1-like lipid interacting stalk" evidence="2">
        <location>
            <begin position="469"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2173235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="651" mass="73785" checksum="D35A619EB7F697AB" modified="2022-01-19" version="1">MVVLQTRQFSIGRLFITATRVPVVLAGAAAGGVAYVNHKIEEYKEKGQDLMSAVEEQLESFVNRAQSLGENIRLPSFLTGLFERTPKDSDPLAEDIREALTSEEKAAKKIILRMHQDELADLAQKLDDAKALLIKLDAFDEKQEHVSLILPPVAVIGQQAYQLVQQLFGLEIPTESSSNGTIHLLIEYDPNCKEHVLKLGQDERVPLSEASNLIASHTSSDPLHITVISPKYPDMHMMLLGDETNVATVIDPEALVVATDFASQQTIDPLGRRSIVVEANDKYTPRRLIAYRLEQYITPVLFDISRDANRRLEEAQYSFKVDYDGRSASAESYLAGRMEELKQGIAELETKFNRQHVRDVIRELIEREMIAVCERTCWTTQDADPEVAGGLITRSGVGRSTTHLMASSVMQAVQDLSTQVFGAERHEDARDRVLTFAQKILRTHEPTACDQVENTIKPFKYEVEVSEREWATALRRAIEVVEQEKKRCDDEYRSIQQNVDRSQFNAAMKQLAKTKAQDIKELPFDDRIIANAVHAMALRDKSALLKMRLAVLKSRRCRSLDNKSQCQEAFLCAVTEKVTYTVELLNEFFFEFSREIDDQLVYGMTHKQIAQFARENPHIMAQLDAQDRRRQLEDVVSGLNDLARHRVADPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGC0</accession>
    <name>A0A8H7PGC0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_004727</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGC0"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2173353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="481" mass="53291" checksum="6405692414B4F7B9" modified="2022-01-19" version="1">MENEKSQVDMCEKPNNDSKSSLKSSDNSNDHSTVIVPPNRVLLYGTTAFVSLGALLFGVISTIIASDTWLKEFGYPDSGVIGAVVSLFDVGCLFGALSNAWTAFGVIIQTFAVHIAMMIIGRFILGFGVGALSGLVPLYQAEIAPAHIRGRLISIEQMVLCFGEMIATWIDYGFSYLAPTLPIWWRIPLGIQIVPAIILVVGCFYILPSPRWLAEKERWDECLSVLTRLHGTEAAQIEFRQIQETIKMERETSVGSYAELFNRRYRKRTLIAMATAGLQQLTGTNSILYFAPTLFGKAGLDQQASFLATGGVGIVLFVTSWIPIWTIDRWSRKGYFMVGSFVMMLAMIGIAVTQAMTELHPNIIGNAGNVIVFWPYLFYTAFNITWGPLAWLVPNEIMDITMRAKGNALATATLWLCNVGVAQFSPMIVAKINWGLYPIYAGINFISIFLIYFFWVESANVPLEEMAALFEGIPRESRTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGP1</accession>
    <name>A0A8H7PGP1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UPF3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_004688</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RENT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGP1"/>
    <dbReference type="OrthoDB" id="18087at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12455">
        <property type="entry name" value="RRM_like_Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013962">
        <property type="entry name" value="DASH_Dam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039722">
        <property type="entry name" value="Upf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005120">
        <property type="entry name" value="UPF3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112:SF0">
        <property type="entry name" value="FI21285P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112">
        <property type="entry name" value="UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08653">
        <property type="entry name" value="DASH_Dam1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03467">
        <property type="entry name" value="Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF3" evidence="6">
        <location>
            <begin position="42"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="233"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="333"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="372"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2173314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="694" mass="76059" checksum="2C232761BC8841CF" modified="2022-01-19" version="1">MSEPATEVKVDSSATAPTTEQPKKKKDKKKPRKRSSKKALPKTKVVVRRLPPNIPEEIFSNSVKQWVNESTTGWQLFVPGKLSTSKAKQHVFSRAYFHFLTMEAVVAFHQGYDGHLFMDGKGNEYRAVVEFAPFQKIPKEHKTPDPRQGTIESDPEYIAFVESLSVPEPPPNSTGDAKDGLSNVERIENRLSLITAQNQLAEQANKPKTTPLLEHLRAQKAAQAAAKAKAQAAKAAAKQSKQQAAKGEGAQKVANEPSNKKALRREKDRKKREEKKAAAAAATGPSNEQTASPDAKAAGEKPKREAKTKIKQEGVQQIVKILGRQTGKDANAASPSKDTTKDASGTQTAAIPKAAKSTEGNNTGSDGAPALTRKEKEKLRQQRRDLERQRREKENDGGRLDSGSKEQSSSGSQSIRGGGRGGGRGGGRGYLSNRGGRGGAGRAASSEVDSAKTNTSYAVDYLGPKCVNMGIETGERTSRRFTYGITQSTPAAGHEHASDADNATCFDILQEPLADLAASFELMHSNFEQLKQVNDALVDFNDAFGAFLFGMTANGSSIDWPQAPINASFDRLSHKQQATRSSLCIERLTIYSLLLTHNAHILYFRKIDIRKIIERLPLKFREQMEHTKNMELILKTLRAAPDGLNMQSIVNQSELPKHRATECLNALVHSKDVIKVNKKVNLVYKCVLRNYIAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGS1</accession>
    <name>A0A8H7PGS1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGS1"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2173359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="148" mass="16047" checksum="F3B52743D9E1DA4A" modified="2022-01-19" version="1">MLPGVSAQSTGPLAVAQTITTQLAQNEVDLGFGVLLSASQFKSPLNQVAKGPLAAVSSLSWAFDLLRVRQDAPLPARIYDCKRGVFSKTAKLMERNSNNSWLSTMTLVVSNWTLGFLGILNHLDSDGWSWWYVVGVIAFSIADDKVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PGY6</accession>
    <name>A0A8H7PGY6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alginate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_005153</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PGY6"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034194856" description="Alginate lyase domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate lyase" evidence="4">
        <location>
            <begin position="89"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2173733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="437" mass="49210" checksum="4F70FF8284CD0F0D" modified="2022-01-19" version="1">MKIFSTVLLLTVAIVNVSQAGVIRKRLTPVVQTPISFSNYTLEWKSLTTLKDNAARQHGSSKYPHPAYKLLQSLADEAVKKPVYTIVNKPFLPPSGDKHDWLSYAPYWWPSSNCTATDKNNDCPFVNLDGQVNPDVYKLNDQKNLEYMSMDTETLAMAYLVFKKDAYAQQAANMLRAFFLNNDTMMNPNMEYGQIIRGNGKSATHIGRAEGIISGRALISPVRAVKILELSGTRHWGKNDTAGMVGWFKSFHDWLLDDKIAIDEGNTTNNHLSYYTDSLITFSDFIGNYSTIETKVRTFFTTNLPKQILANGTQPMEELRTLPFHYSAFNLEALVYMANFVSQRDPLTHGPYITNAWNQTGDSIITAVQRLEAVVAGKTGQIEPGADITEADYSVRAVGIQYPSQFCHTYKASQSHVVPYLNLWPLWTPHSLWNCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJ48</accession>
    <name>A0A8H7PJ48_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_006004</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJ48"/>
    <dbReference type="OrthoDB" id="77564at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033053">
        <property type="entry name" value="Hir3/CABIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502:SF7">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2174942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="121" mass="14607" checksum="3C11B600582A577B" modified="2022-01-19" version="1" fragment="single">SHSIAHLKPEEVTAYQLIFDRLAKVRKIDRRHWHHRPIFRHAWMHYYIYRDAEQAKADLMPLFALKSNLKSHISIWKPGFERPGKHFEYAHQYTVFMIELAQVTNDANTLKILCRKLRKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJQ5</accession>
    <name>A0A8H7PJQ5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_006037</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJQ5"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF9">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="62"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="64"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2174975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="395" mass="44748" checksum="E9FF4DD59A56E3AC" modified="2022-01-19" version="1">MSASLTNWPVAPTSNNDYNDHLENNLTDSFNMTGPMERIDHDPYQNNNQSYTQDFKPTFYNPFEVKHRRRTTRAQFKVLEKTFQENPKPSATIRRLLAQRLNMTPRGVQVWFQNRRAKAKLQSQQDRRGSESSVITRNEECTNVNTTWGQEDSKNSPPSLAYDMQRFSSFSSDSSTQSVHPSYAPSETYSPSIKNYYAGHPRMMQKKYEPVQFMSNESFQGYQFQDHPHLRTAYSALQEEMPQTAMLRRNSCPANLISNMLPMQMLQQCQVPKSSGNNFLTSPNMPSKVRRWSSINADAIAEQEQLSYMTSIAPSESFATPSSVGSTLSRWDVDSASSVSSSPSSSLRFPMTNGEASPVEERMAPSSLPMGFSDTPDSLKLQMSQLQCAIDTFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJX4</accession>
    <name>A0A8H7PJX4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">IRG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_001039</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJX4"/>
    <dbReference type="OrthoDB" id="422720at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030385">
        <property type="entry name" value="G_IRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007743">
        <property type="entry name" value="Immunity-related_GTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051515">
        <property type="entry name" value="IRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341:SF17">
        <property type="entry name" value="IRG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05049">
        <property type="entry name" value="IIGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51716">
        <property type="entry name" value="G_IRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="IRG-type G" evidence="6">
        <location>
            <begin position="119"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2175392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="348" mass="38449" checksum="F17B0F68B9B62B9F" modified="2022-01-19" version="1">MAPQTAYDLKVLETAKRGAQTIGLVSLAVVSAPVVMIACPLLGAYEFANAYDAELYTGSKVMDGIIGGLFGVVTSPLAPFYVAWGVIEELYRIPPPQPLPISKSYYEQAYREYGLDCLNFYNIAVVGVTGTGKSSIVNGLLGYRDGHPYAAKVGEVEVTSKPIGYRHPVLPTLMIWDMPGAGTRRHPAKSYYEDKYLEAFDALLIVTGDRLMATDIHIARAAQAAGQSFFVARNKMDIAIQSRLRRKNIKQNVSHMQWATTVGELANDMQIQRDLKSFDFSTENLFLVSAWDLQNLVISLRNHQAIGDMRLIHEKILISTLLDTIAEKRRQELASDSGIETDQSSHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PK30</accession>
    <name>A0A8H7PK30_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exportin-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_001236</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PK30"/>
    <dbReference type="OrthoDB" id="5548448at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044189">
        <property type="entry name" value="XPO4/7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596">
        <property type="entry name" value="EXPORTIN 4,7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596:SF1">
        <property type="entry name" value="EXPORTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2175589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="762" mass="87003" checksum="5F37DDB46050154C" modified="2022-01-19" version="1" fragment="single">MDVALVHAHFVEACSDFQVPATRAAAEQVLTEFRHTPQILPACQYILDNTESPMVQFQAAVAVSEIVIREFSAYQRQDLVNLKHFMLSYCLHRPRLPKYVRDQLLLAVATIMKRGFMDWSEEEREGMFTNVKELWDMQDGHGPLLASALSGGYIDQFSNMKSSIGFNWEFHHKCKVWFENHMLQRLFQHALQTLHNQCHNREYLTTPVPDILAETIVLAEKILHWEFDATSDQTALPGVAAPGSEKEDLDSDQIDIRRTFTLFPTSWRPLIGNRDVIWLFFSAYMLVQSDERLAHRLRQCLIQLSGQSPKFFENNQEAMNDYINAMVQGIVKCLNDISATATDANSIEEQGPQILGVIQVVRRLIENIPLILLSHQGDFYRLLNDVTKLTTICLRGTVEDVDQGWISEAFDECLATWVSLVMSLQSMEEPSHDTNTRLQQHEMETLQQYLKNFSFLIVENYIETRIEMSNASVLSDEEEVDGGMNDRELYGDQLTSIAVLARLDPSQSLRQLQHLASDRFARLKTLFSNGNEESERQMDIIHEHMHWILLVSGSILADAGEGEKPLIPNSLMQLSGMQPLQEDQVVNLSRTFLEVLQFLSNWSTNSLEASYCSPQVAETLIWFFERWSKSYLLIDEEDYGYVSPNIARIFGKPGSSEGEGLHIVDTLIEQIKANFVMWNAEKDVLTQVIRWLNTCGISRNLKNGFLMSDRFPGFIEFITQILEHLPEIVHNSLVQTIVSISSAASDGSVRDKYLGLIFGMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PK70</accession>
    <name>A0A8H7PK70_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_001083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PK70"/>
    <dbReference type="OrthoDB" id="10258358at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010297">
        <property type="entry name" value="DUF900_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05990">
        <property type="entry name" value="DUF900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2175436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="31450" checksum="A1D4734A5B9E8F9F" modified="2022-01-19" version="1">MSGTMTKQIAQPVVKQLFVELPKMKVLSRPPDARSEITVYVKGFLAEGDTPDNFADWMHSHRLLVLSKNWEPTALGFSWPSGTASVPLPFATLASASYLLASNLKRLSQLRLPTPATILGAFAVDIGLHTGRLAYQFNQATNESKERAEILALRLLRLRSEHEHVRIVAHSLGCRHVVEALSKLKPDERPDSVHLCAPALVAEDVMPYIGKGQGGLARNKTIIYYSPKDMTLGVLLRAILGGARPLGEAGLDPKTPIDSTVQLVDASSSLGFFSHTDYADKFHFMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKY4</accession>
    <name>A0A8H7PKY4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_001016</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CENP-W/WIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKY4"/>
    <dbReference type="OrthoDB" id="2543597at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13732">
        <property type="entry name" value="HFD_CENP-W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028847">
        <property type="entry name" value="CENP-W"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052484">
        <property type="entry name" value="CENP-W/WIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34832">
        <property type="entry name" value="CENTROMERE PROTEIN W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34832:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15510">
        <property type="entry name" value="CENP-W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2175369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8841" checksum="2D3DA06583C05336" modified="2022-01-19" version="1">MARLYSRTTVKKIVKAHNPRSSLSKNVDVMIYLDYLLFLQRLAREADAELLQTKGTMLQAHHLQKVVEQTLQQFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLG2</accession>
    <name>A0A8H7PLG2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLG2"/>
    <dbReference type="OrthoDB" id="2448307at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF1">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2175396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="335" mass="38329" checksum="A408E23D78F87F92" modified="2022-01-19" version="1">MWIISRVQRMIDILNAQHLNQGADDITSAYANAQSLLVYYILFIIAQLFTVALVVDAIYQKNTIQLIALCLFEFGMGAYSVIQYHQSTTLFSGDETAIVVAYLQGAYNAARWAEITVIVLMVLGVLVFTFLAYKLYLEFGWHIYKKIGADLSMRDRYKMYQIFIMMLKFDFFFFLGFSVQYLALLILTSESSLTPEDSKAGIMKQLVEHIVLSCVVTIAMLMLAFWGWLQLIREKKNYIYGFILGSFASMAYFIYMLVEISQHPQNYQGTKIFLTFFLCVDMVLIIATVPVSIICLRNFGLGLMNHITHSNSTANSTHSMTPIGQEKSNRRWSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMA5</accession>
    <name>A0A8H7PMA5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="13">Aconitase</shortName>
            <ecNumber evidence="13">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">INT43_005698</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMA5"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01578">
        <property type="entry name" value="AcnA_Mitochon_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01584">
        <property type="entry name" value="AcnA_Mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="15">
        <location>
            <begin position="72"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="16">
        <location>
            <begin position="588"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2176458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="787" mass="85349" checksum="1D23E102DEEB4F76" modified="2022-01-19" version="1">MLSSKTFMKAAKVVTPAINVSTRTYAKAASNWANQKVAMSNFEKDKYINYQRIEDNLEIVRRRLNRPLTLSEKIVYGHLDDAENQEIVRGQSYLKLRPDRVACQDATAQMALLQFMSAGLPSVAVPSTVHCDHLIEAQVGGEKDLARAIDINKEVYDFLATSTAKYGLGFWKPGSGIIHQIILENYAFPGGLMIGTDSHTPNAGGLGMVAIGVGGADAVDVMADIPWELKCPKVIGVNLHGSLSGWTSPKDIILKVAGILTVKGGTGAIVEYTGKGVDSISATGMGTICNMGAEIGATTSLFPYNNRMRDYLVATKRASIADLADSFKHNLIPDEGAKYDEVVEIDLDKLEPHINGPFTPDLATPISKFKDAVAENNWPKDLRVGLIGSCTNSSYEDMARSASLAEQAANHGAKAKAQFTITPGSEQIRATIERDGIMETLTAAGGVVLANACGPCIGQWDRKDVKKGEKNSIITSYNRNFTGRNDANPATHAFVASPEIVTALTLAGDLTFNPLTDTLIGEDGKPFKFDAPTGFELPPKGYDPGQDTYQAPPADRSSVSVAVNPESNRLQLLEPFKKWDGKDFEEIPILIKVKGKCTTDHISMAGPWLKYRGHLDNISNNMLIGAVNAENNEVNSVKNAFTGAYDAVPATARDYKARGVRWVVVGDENYGEGSSREHAALEPRFLNGAAIIVKSFARIHETNLKKQGMLPLTFANPADYDKVQPEDKVDIVGLDSFQEGKPLTLRLHHKDGNQEEIKLNHTFNPGQIAWFKAGSALNLMREKSGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMD2</accession>
    <name>A0A8H7PMD2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_005629</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMD2"/>
    <dbReference type="OrthoDB" id="195231at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034758696" evidence="3">
        <location>
            <begin position="29"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2176395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="323" mass="35201" checksum="40760A90CC8F1EAC" modified="2022-01-19" version="1">MSTFKKLPLLLLWLTAPLLITAVTFGQACDPTTSHLNAYLTYVDACDDPSGMYACASNNTCAFKTCVNTNYLKNWSNTTHKFPSRCTGTKFCPDNGLQCLPMVAQGGACELDRDDECAGGAYSICLNRVCSIKGVPVEGNCVIESTQFAYMDQNGEEAEGTYERDNCTVGAYCENTKCIAGLPNGAPCTQDRVCFSNSCYNDGVGGAGFCGNPPDSFKEVPISTWAAIGVSVLVFMLLILLALWFLHRYQSKKEHAKIQRFFDMQDALRQYSGNDTPEMSEGAILLGTPRLYAHSNKSDSSIVSDIRNRMSMPGSRPSSQLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMD8</accession>
    <name>A0A8H7PMD8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">60S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_005352</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 33 different proteins. The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and at least 46 different proteins. uL22 is associated with the polypeptide exit tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMD8"/>
    <dbReference type="OrthoDB" id="10254664at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000012">
        <property type="entry name" value="60S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00065089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2176119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="20629" checksum="9C551CA3449C313A" modified="2022-01-19" version="1">MVRYAATPSNPSKSSLSRGSYLRVHFKNTHEVAAAITGMKLSKAFTYLGDVQEHKQAIPFRRFNGGVGRTAQAKPFKTTQARWPVKSVKFVLDLLKNAESNAEAKGLSVEDLHVANIVVNQAPKQRRRTYRAHGRINPYLSHPCHIEVILSEKGESVQKEDSGKKVSKLNARQLARQSRTKATHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMR0</accession>
    <name>A0A8H7PMR0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMR0"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF283">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2177059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="34883" checksum="312C8ECA97966FDD" modified="2022-01-19" version="1">MAIEFTDQTTADEVGTALTNEIRGKTVLITGATVGGLGAEAAMVLAKHQAKLIILACRRVEAVFETINKIKQEVPDANLRPLILDLASLASVRDAAKRVNEYAEPIDVLINNAGVMAPPYFLTEDGFEGQLATNHLGPFAFTNLIMPRILASLTGSPRIVNVSSTVHWLSPIRYDDPGFQEGKTYNNFIAYGQSKTANILFSKELSRRYKDQGLLAFSLHPGGIQTNLLRHFDIAKVLQEGVKDYKGNSFDLTAIKWKSIQVGTATHLVAAFDPSIADQNGSFLEDAQVHNELARPDALDPQNAKRLWELSELLLAGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNH0</accession>
    <name>A0A8H7PNH0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2 10">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_007944</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2 10"/>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNH0"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07857">
        <property type="entry name" value="STKc_MPK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000013">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000647">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="390"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2177287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="438" mass="49606" checksum="BC4879161D6D1670" modified="2022-01-19" version="1">MATHHSFPVLNQQFIVDKKYTFIRELGQGAYGVVCAATNTQTNEQVAIKKVTKIFDKPILAKRALREVKLLKHFNGHENITAILDMDILNVHDYNEIYLVQELMEADLHQIIRSEQLLTDAHFQYFVYQICRGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSDSPESNAGFMTEYVATRWYRAPEIMLSFQNYTKAIDMWSVGCIFAEMLGGKPLFKGRDYVDQLNQILGILGTPDEVTLRRVGSERAQVYIRSLPPMPRIPYEKLYPKANPLAIDLLNKLLCFDPALRITVEEALAHPYLSAYHDEDDEPVHHQHFDFSFESVEAIDDMKKLVAQEVMSFKASKQAMLQPQLNAGANLRRKDSLSTQDREALEKTKQAAAAQGKAGDHQYHQTQGVAATAGGNVQPPDNIPMEVDELERELSGQTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNJ0</accession>
    <name>A0A8H7PNJ0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNJ0"/>
    <dbReference type="OrthoDB" id="2258835at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="771" mass="86400" checksum="849096796540976D" modified="2022-01-19" version="1">MTGRTRPTHSRSLPTERQLSSISNTTNDEYDVVEDKQHPTYTPPSPPPESSQVHDSDDESVDPSLSSSASSDDVDPDALLQLMSDQGTPTLHAIGRHSPLLDDDEDDDCDIDSSNSSLELPDSAITDATSAAVSRGPTVVRVLYLGCATDNDKSNILKKLSEGLAEIFLQRPSQVFPDTTLHADPTKFKERKHNILALSTTATTEHIIDPIIDEDEPIETYEDNGLSIIEADFTRNNERRQNPASHETIYDYVIRHMDPASSVNGSISSEQSESCTRFDGYVYPDATPDGVDLIVYFYSGLEIDEERQSEIEDEMVLLYKMRQLGIPVLPILSSLITKKSKKLDASSYRDQQSMSSGSYVSSTRSSQRRSSPKRLNGNHRSYDQHKSSNADYNQIMMENRTYLSNTFAEYRIQCLDVLNLEIGRPSFHRRTRRTSSEDSERSKRDNSEDWETSSLMPAPWQILTVEQFASVDKRAVYEALKKSREMAVKRETVREVIKAKQRVSHSNEKPDSKAKLQKAKFKEALIRWAFGVILPFMLLLCLLQGGSTGMSHLSNSTTVGPPTIAKLTPVWQVADISDGKHLFVVEVFDHRGRLSSLGPDGVKLKSSKLGKSDQNVHTALMEETTFGRYSLAITSPCLDKSYRKGISIEFEAHGGIPVLNSPVTLTDQECPRPQTQAVPKSRTRRSKLSNPSAQANLQRTFRKRRWYRSSDFIVRNTQSFVAFKVISQLFGVIYNTVAFFWDEVGFHNLVQWLPSSSSSSTTTTTTTTTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPK1</accession>
    <name>A0A8H7PPK1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_003317</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPK1"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000004">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="4"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2178064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="156" mass="17812" checksum="1A6E5C3D385B2A94" modified="2022-01-19" version="1">MSTPSRRRLMRDFKRLQKDPPAGISGAPCPDNIMLWNAVIFGPGLLFDIAETPFEDGTFKLVLQFDETYPNKPPSVKFVSKMFHPNVYANGELCLDILQNRWSPTYDVAAILTSIQSLLHDPNPNSPANAEAANLYRENRKEYVRRVREVVETSWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQM3</accession>
    <name>A0A8H7PQM3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQM3"/>
    <dbReference type="OrthoDB" id="5596566at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026187">
        <property type="entry name" value="Aven"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16524">
        <property type="entry name" value="CELL DEATH REGULATOR AVEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16524:SF2">
        <property type="entry name" value="CELL DEATH REGULATOR AVEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="345" mass="38957" checksum="24990300FCC74BAE" modified="2022-01-19" version="1">MRPDEHKAKASRRYQSKHKKQGDPTALEVAQARRAAAKAKVAGNSLSAIRRRNADIDQASQTASASSEPDDTTTPTKTFSRRKIASNKDRYEEKSEQDQIIEDAELGIDRETTDLVRMLEEKEAENVGDNSTFFRFKEEQEWEEDDELQSEIEQKLYHNLLALDITELEAVLSKLPYRSRLHLADSDRLVPQSLDMSVSKNRKPIVPGFVKNAKGLVMFKKPVVQSQPQAEGIMITNDGSNHEKVEAAKKAQQSSRPAPQPSITQSKEEITVHDDAKDQQHSKYEDDLDSLLNQDLPADRSGNQNYKQPLKRPNMLKKPVSKPIPPKKSSNAADTDDAWLDEMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRG3</accession>
    <name>A0A8H7PRG3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_001597</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRG3"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF88">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN CTL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="558"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2178751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="616" mass="68233" checksum="7CB7FA6467B4DF19" modified="2022-01-19" version="1">MESSVLSFGKNMYGRLRESVMSSNYRSPYSLVDEDDDNDDDDSVQSPSNMFFSVQAPKQDSIPLTDSRAFYNERITQGDDDTSELYDSDYRGNQYSDGDLGYSDFSYARMSEFQSDAEEQPQPSAIYLDVPPPVSSSNPQKALAESLLPTTSAIPAGVTTIKPQTKLKDPLFAFLYFISLLIFTISGLITLFTTDSNAIEDFSRGTVYKAIKGSAGILALMFSLALTVGAVWMMLLRKYARYLIWGTIASVPVVTFGMFLWTMIESLQSNFIEGSGPSGHDTRLTIMSFLPLITGILYLRILFGNRDKVEQTLTVFELACDVLRANPEAVLLSVCLMGVFVTFSSIWITFFSRLWLIGHSITPSNPTGMQWVVENNVYLLASFYVFFYLWTSSLLINIQRFSLAGVTAQWYFHRHEPVDAVTANPSKAALARACTTSLGTVALGGLLLSIVQFLQFVSFQVQKRLKASNIIFGTIIGCLKFIELIVGAINNDTIILSGITGESFLASARSVTKVFRRNMLSGVLEGLLTRMLLNISSLMVSLFSGFSTYVFVSRSLHSPHGMMVGFLAAVVPFYISRFFTSLLNNIIDALFVSYAIDLDTNTVHCNAAHKVFGSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSG8</accession>
    <name>A0A8H7PSG8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calcium-binding protein 39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSG8"/>
    <dbReference type="OrthoDB" id="609103at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="43048" checksum="149BE4F81DF420C7" modified="2022-01-19" version="1" fragment="single">RHFPQYIAMNFNLFKPKQKTPPELVRNAKDAVHRLDTSDKRKATEDISKTLLAMKTILYGDGGLLTFPCIIAVGDMLWTSQWPTLTNNDPIPEQVAQLSQEVHNNDLLQLLVFNMQRFEFEASTSYAEYGSIGGIVMRQIGSRWPTVEYLCTREEVLFTLLRGYEHPEIALNCGLILRECLRHEALAKIYLYSSDFYLFFDYVEMSTFDIASDAFASFKELLTRHKQLVAQFLEANYDKFFEHYTKLLMSSNYVTKRQSLKLLGEILLDRSNFNVMTRYISSAENLKLMMNLLRDKSRNIQFEAFHVFKVFVANPNKNKPILDILTKNQERLMVFLNNFHNDRQDDEQFNDEKAFLLKQIEDLKPSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSP2</accession>
    <name>A0A8H7PSP2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003602</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSP2"/>
    <dbReference type="OrthoDB" id="10378301at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034803956" evidence="3">
        <location>
            <begin position="31"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2179819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="232" mass="25648" checksum="3C10E18629716B2B" modified="2022-01-19" version="1">MAKCCCCLPLRLGALLIAIWFVVNGTTASAALIVQEEDILDVHVYLIDMGTRLLAWIMTLACFAMSVINAGLIFWYKDQYLGKCNNEDYLSKYFNVQGDTEEQVLQACQKYFQNVAIASIITTVILGIMNIAFAVKLTQWLVQTRRDRNEANRVREERDQREREEAAMASSGKPPRKSGFFDRFRGTQNGTQNTAQVGPSMSETGGPKADINGANYSSGNAGDYSTGNASNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUR0</accession>
    <name>A0A8H7PUR0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucoamylase</fullName>
            <ecNumber evidence="9">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_004054</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="9"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUR0"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000018">
        <property type="entry name" value="Glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046966">
        <property type="entry name" value="Glucoamylase_active_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008291">
        <property type="entry name" value="Glucoamylase_SBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF12">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001031">
        <property type="entry name" value="Glu-a-glcsd_SBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00820">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034323910" description="Glucoamylase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="13">
        <location>
            <begin position="480"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2180265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="593" mass="64350" checksum="1AEEC282004E1134" modified="2022-01-19" version="1">MKITALLPVLACLGRLASASPTASSSNSYLTKEDPIALKRIMDNIGPNLGASPGIVVASPSTEDPNYLYTWTRDAALTVKSLVDRVAAGSDKNLISTIEAYIKVQGALQHIPNISGNFSDLSGLGEPKFNINATEFTGSWGRPQRDGPALRATAFVAYGNYALKHGNSAFVTKTLWPILKNDLDYVTKYWNLTGYDLWEETMGSSFFTIGASYRALTEGAKFASKLGHSSSSYVNQAENVLCYLQSFWDKSSNAIDADIANGGIMRVVDSGTTVGIIHGFDYKAGCDATTFQPCSDRALAHHYNLVSTFRPLYPLNNGKTVGEAVAIGRYAYDVYYSGNPWYLTTLAAAEQLYDALYVWKRQGNLEITDISLDFFSQFGIHVKTGTYKSSSSTFKHLVTNIEKYADGFVEIVAKYTPSDGRLHEQFSGWNGTAVSAKDLTWSYASVLTTKAAKGGSVPASWGATSIKVPHGKCKFGPEHTVNNDIIDVKFSITDTNLTSSFGTSNIYVVGNISELGGWSTSAAVELHGVSDSYGLFSTIIKLPPSTAFEYKFIEKLNCDEAPVTWENYPGGGNREAKTPSKGSLTLPKATFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PUR8</accession>
    <name>A0A8H7PUR8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PUR8"/>
    <dbReference type="OrthoDB" id="4199702at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034068373" evidence="1">
        <location>
            <begin position="25"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="356" mass="39014" checksum="15DA1B7EEF4848D6" modified="2022-01-19" version="1">MQYKKLLLLFSVYFISCCILLVSAFSFDFSEKKDVEAQAIVKCGGDTDDELHKHEQQDNDYEHHLDYAHAHDHGCGYKDHGDDDNNDSNYISRASVSILVDGKTYRIPCGAGDFDISQICSDACGNDVTASETATLVYENGTGTIVSIIAYGTGTNIIPLQYICEQKSDSCGVKCSPNQNCINACPTGQHCALSNNVTIYQCVYDNIPNSCGVRDPCLRCPVIKIGEATCVCINSVFTTVPDCYESFNWNGDFFVDDENYASPPNNVINKFRGSSYISRNKPFNMISVFLGNPPFGAKKAITTFTAILKGRQVGAPVIATQNGAVYTFPAQSQNIHLLQITPVGESQFFALDDFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PV85</accession>
    <name>A0A8H7PV85_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003622</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PV85"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF15">
        <property type="entry name" value="HMG BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034740247" description="HMG box domain-containing protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="424"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="560"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="424"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="560"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="377"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="536"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="658"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="658"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2179836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="707" mass="79852" checksum="28FC9474673A94FE" modified="2022-01-19" version="1">MQFIINALLVRVCCLSITFKVLASSIPRDLTASQLDDFPLLSSEIETYLTGTVRKYFVAIEQLTWDYSPDQWDHYHNTSLNESPAKLWLATSTSTIGTKYRKSLYRAYNDSSYRHAVEIPQWQGLMGPIFRAEVGDTLEIQVRNLATKNYSMHPHGVKYSFEMEGAIYQDALSNSIPPNQTYTYRWEVPPRSGPGPLDGNSLVWGYHSHVSETDIFDGLFGAIIIYTPGTLNADGQPKDIDHEIVSTIIVSDENSSTLLDQTLKNISATFNKAEVGNADFIKSNKKSTINGLLFSNPKDLRFQVGQNIDWHVLAWAFSRITDNIYSVPYVDFSEPTPLQYAVSNGSAFHIPHGSLDTSPFHSPTLQQTQLHAPYPMLQNMQPPQLHQPTVDVKKEQKKAQTESKPKPKVVRSRLPQNGQVPERLVRPPNAFLLFNKEMRKKLKDKNPTAKVAEISKEVGERWRNLTPEEKSNYTLQANELKANMRAVHPHMMYIRRTKEELAHAGVQTKSLRRGDLTGSETDQLLGGDVDAGLLGLGIPTDNSSRMPRKRKGREKNPAAPKHPLSAYFWYLTEVRPVTMQEYPGSTVGQISKIIAQRWRQFEDHEREPYVKKAQEDKIRYTREMQVYAAKCSPNLGRGTRNKYRTTDAELAALNKATEEEHRLDEHTDSLLQSSLDPASLLSGPFAEGSSLQSGSLDNDPDQYVNAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PV98</accession>
    <name>A0A8H7PV98_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_003927</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PV98"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2180139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33167" checksum="8F6DA8C9116C5EB0" modified="2022-01-19" version="1">MSDSQSLKSGLTQEQLEKFDRDGYRSFLIIPNFFTEEQAQRLKSKADDLLENFSLEDHPMTRFSTGRGDNVKHVGDDYFLNSGDKIRFFFEEGAFDDKGELKVPKSRAINKIGHALHELDPEFKDFSLTPTMSALASSLGFQKPQVLQSMLIFKQPHIGGTVPIHQDSTFLYTEPTSAVGFWYALEECTTENGCLYFLPGSHKTTPIDRRFVRAPGGGTTFVGGGELEVDESKFVKAEVNAGTLVLIHGSVLHKSENNASSKSRYIYTFHVIEGKNRYPEDNWLQPTEAMPFTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVC5</accession>
    <name>A0A8H7PVC5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_003973</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVC5"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2180184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="393" mass="44250" checksum="BE73FE97FCEDB26B" modified="2022-01-19" version="1">MQHSSTYLRLYYRSLRRLSPTYFCRAHYGCYSRIPPTSSPSARLYKQAYSTQDTASSFLIAPREIPGKSVKKELKLRCTEFDEKGSVKTTAGDFLKTDLCTQHSLLPRDLRTIDTHHINPKAAILVRSEAILINLAHIRAVIKSDLVVLFDTFGSTNSYNQSIFIYDLQERLRSGNRDGLPYEFRALEAMFISVISSLHSELDVLNGLVTKLLSDLEDSVQQDKLKDLLQYTKKLSDFHQGVMTIRDAINEVLDQDEDLAAMYLTEKKAGSPRDPADHEEIELLMEAYLKQTEEIANKAATLISHMKSTEEIVQIMLDTNRNSLLLFELKLTVATMSVGSGALVASLFGMNLKNYMEDDPMAFGIVTGGTLLSVALILARAMRKVRVLSKPYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PW02</accession>
    <name>A0A8H7PW02_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_008673</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Common component of the spliceosome and rRNA processing machinery.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PW02"/>
    <dbReference type="OrthoDB" id="5364946at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000015">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit NHP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="10">
        <location>
            <begin position="42"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2181091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="160" mass="17770" checksum="FD44FB9BDF3DA15B" modified="2022-01-19" version="1">MGKEKKEKKVKQVAGSDNEEETRVLEASPIAHPMAEKKLTKKLLKTVKKAAKAKHVKRGVKEVVKGLRKGEKGLVIIAGDISPIDVITHVPVMCEDEQVPYVFVPSKEDLGTAGSTKRPTSCVMVVLGGKKQDKKAAEDYKELYEECFKEAKQMDEKLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PW35</accession>
    <name>A0A8H7PW35_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PW35"/>
    <dbReference type="OrthoDB" id="435520at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF10">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="155"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2181323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="462" mass="50860" checksum="7ED0873967D42D16" modified="2022-01-19" version="1">MHDMGTGHVAGKVEPAMAAPFPNNSKSTPVPSSRRKPSRTRTSDQDASDEFFSTPASQAMPVASNIVFDPYPAAQPLAKHSSRRMTSGSSERSKKSKLEVLNDPLLHQTFLYRPRGLAKELFPSHLVGYAEYGIPDGHPVIVIGGLGCSRLVGVMFHEISKRHKIRMLIPERMGYGLTEACSAADMTVLQWADVVIQFADHLGIQRFSLIGQSVGAVFSLAVATLYPERVTGTVHLISPWVPTSAANTFRWTKRLPGGLMTRTLSLGMDAMWGISKATTMGSTPNWLAVDTSQRSSSESLSSSISGKNPSVTSPTSSNFQHALIALEDDELLAALDEDYEDLPTDFPPHRPLRHMVRLQQISLFQSMNKMRMAEPSSQGQTNDVLVALEKYHSFGFNFSDVQVPVSVVWGDQDNLIPLRGIEWMASMMKDVRVKVLEGEGHDLVWKEGVMEWAIRGIQASVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXK6</accession>
    <name>A0A8H7PXK6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta-catenin-like protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_006902</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXK6"/>
    <dbReference type="OrthoDB" id="1898821at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001136">
        <property type="entry name" value="Beta-catenin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039678">
        <property type="entry name" value="CTNNBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978:SF0">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08216">
        <property type="entry name" value="CTNNBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01156">
        <property type="entry name" value="DUF1716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta-catenin-like protein 1 N-terminal" evidence="9">
        <location>
            <begin position="88"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="493"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2181976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="627" mass="71558" checksum="AD7DF337837642F0" modified="2022-01-19" version="1">MNIDELFKIPAIPSGKNKRKLPDNPSMEFLDKYKEASRDDEGEGSSAKRRNIMEEDTDEAGDYELGEDDYDNGEADEEEGGRFYGGGLTDEQRRMLELVDEIDAEEPEALDAATVKKYILRFEKAINKNQEQRVKYPDNPEKFMESEADLDEEIKNLLSLTQAPQHYHELVNLGSVPSLLSLLSHENTDIALDAIELLNELTDEDVGPGEDFADEEKAETIIESIKIFVDALIENQLPELLVQNLQRLDENEAADRQGVFNILSVFENLVSVFPRHSEHIVAKTDLLPWLLKRINTKVYDSNRGYACEIIAILLQDSRDNRVKFGELGGIDVLLRVLSAYKRKDPADDDEAEMMENFFTSLCSALAEPEIKKLFLEGEGVELMLIMIKQVMSRIRAVKVLDYALSTPAGTGNCYRFVESFGLKTLFSMFMRKGIKKLKKAYKAYSESEEEEHLLGIIISLFKNLPQDDVQQLRLVQKFSEDNYEKVDRLFDLLDQYEARDKAVQQEIATEKEELDEEDLEEMEDQFYIRRLDAGLFTLQRVYLTIHIVCEENDGARDHATMLLKRRDMTLSDLSAFIEADDALLKEMDTVRGPVLNPIVQNGDLNKKTQNNDVEMPQAEQAASVEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZ25</accession>
    <name>A0A8H7PZ25_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZ25"/>
    <dbReference type="OrthoDB" id="252265at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18785">
        <property type="entry name" value="Inv-AAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2182413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="153" mass="16481" checksum="212B959BF3FB6E23" modified="2022-01-19" version="1">MSNLTHDAKDLELMKMAITQANLSQPIESAYCVGAVLVAATGEILSTGFSRELPGNTHAEQCALDKLPDIAMAENSVCYTTMEPCSQRLSGNKPCVERLIEAKVSRVIMGVNEPPNFVDCSGADLLRQAGIEVLVVPGVEQECLKPNIHILNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZ71</accession>
    <name>A0A8H7PZ71_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein sorting-associated protein 74</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_007330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZ71"/>
    <dbReference type="OrthoDB" id="2189106at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031985">
        <property type="term" value="C:Golgi cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3630.10:FF:000004">
        <property type="entry name" value="Probable VPS74-protein involved in protein-vacuolar targeting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2182400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="37935" checksum="1B3C9678D42B9EAE" modified="2022-01-19" version="1" fragment="single">PSCLNMSGVTRRRVAGGGGNSTSEQNGVGSTEASFSVSSPSEERKIAYDPKDLEDDKDKKEPKLTLMEEVLLLGLKDRQGYLSFWNDNISYALRGCIVMELAFRGRIAMVKDSNRRKFELSDRHIEVINERLTGEVLLDEALKMMKVSEHMSVASWIDLMSGETWNVMKIGYQLKQVRERLAKGLVDKGILRTEKRNFLLFDMATHPIADMAVKDEIIKRVCTTLVSRTTPASFDAQSGLRNGYLRTVAMICSSYAANVLENSLFALSYDMREKAFAKVDEFLADFSVWPFTGTGGKVTVATGTELSMEVVAAVLNVFTKMDSIVSVQYEVIIFRKEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZ93</accession>
    <name>A0A8H7PZ93_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Myotubularin phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_006470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZ93"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048994">
        <property type="entry name" value="PH-GRAM_MTMR6-9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21098">
        <property type="entry name" value="PH-GRAM_MTMR6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="5">
        <location>
            <begin position="124"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="576"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="672"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="609"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="683"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="733"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="777"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="2">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="286"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="350"/>
            <end position="356"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2183464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="810" mass="90807" checksum="BFCAFCB956FD1B7B" modified="2022-01-19" version="1">MAQNRLDLIKVSQVSDVQLEKNQDVISGTLHLTDHNLIFSHSDGELWIPYPIIHYVERRPPSSSDLYPLYIKCRDFLILTLSMPNDRDAQDVFDVVQKLTCITSPEQLYAYSYQPRPPFTAKDGWKLYDPVAEFERMGVGKHDSWRFTSINRDYSFSPTYPRVLVVPTKISDNVLNYAAKYRSKARIPALSYLHWANRATITRCSQPMVGIKQARSIQDEKLIEAIFASNVPNGLNGQVVYGSTAANLIIDARPMANAVGNVARGAGTENMENYRNCKKNYMGIDNIHVMRDSLARMCDAMQGSESIGGGINRFALQRSNWLKHISTLLDGTLVIVKSVHIFNSHVLVHCSDGWDRTAQLVSIAELCLDPFYRTFRGFQILIEKEWVSFGHKFADRCGHISNEKYFINLANTGGSAAANTIKDMQNKLYKSGFHQRETSPVFHQFLDCVFQLIKQHPARFEFNIKLLSQLHYHVYSCQFGTFLFNCEFDRAKNQPQSKTWSIWDYFNSNLEEFKNPDYDPTLDKDISNDGGVLLPDPKSVKYWASLFGRSDEEVNEAAAAAAPLPTVNAVEATEIAESDQEGGGNHVRTIKSDTPPLNEDNDPLRNADTDTGYSSAQQDTPVSSDPLSDPLSADGTPKPAIDFTEVSSRIGTMVNSFSRFTINVGEAMYSRARSTSESVAPRQVERELGSIDRRSPSKTSSSTNELLGAKEPMDHNHDSPLRSSSYPYFEQIKPSTASPTLVSSPLSAANDPLDASPHSPVVATSTWKSPTPPPKPIQEERPIEKSDHAEEQQQMDLKDLPHPLWISDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZC8</accession>
    <name>A0A8H7PZC8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZC8"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2183524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="91" mass="10217" checksum="E06E06265979D2C5" modified="2022-01-19" version="1">MPFLATGADKVSVFVPPHWTFSIAPMYFNHEDLQYYLTAAQKAATHRNLSKNALFCTNMDKIKGENASLVMQAITWSPLQFFTAGFNEVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZV0</accession>
    <name>A0A8H7PZV0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bifunctional lycopene cyclase/phytoene synthase</fullName>
            <ecNumber evidence="8">2.5.1.32</ecNumber>
            <ecNumber evidence="7">5.5.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">INT43_006498</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 (2E,6E,10E)-geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34475"/>
            <dbReference type="ChEBI" id="CHEBI:27787"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="EC" id="2.5.1.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>all-trans-lycopene = gamma-carotene</text>
            <dbReference type="Rhea" id="RHEA:32219"/>
            <dbReference type="ChEBI" id="CHEBI:15948"/>
            <dbReference type="ChEBI" id="CHEBI:27740"/>
            <dbReference type="EC" id="5.5.1.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>gamma-carotene = all-trans-beta-carotene</text>
            <dbReference type="Rhea" id="RHEA:32239"/>
            <dbReference type="ChEBI" id="CHEBI:17579"/>
            <dbReference type="ChEBI" id="CHEBI:27740"/>
            <dbReference type="EC" id="5.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carotenoid biosynthesis; beta-carotene biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carotenoid biosynthesis; phytoene biosynthesis; all-trans-phytoene from geranylgeranyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the lycopene beta-cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.32" evidence="8"/>
    <dbReference type="EC" id="5.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZV0"/>
    <dbReference type="OrthoDB" id="6600518at2759"/>
    <dbReference type="UniPathway" id="UPA00799">
        <property type="reaction ID" value="UER00773"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00802"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:geranylgeranyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045436">
        <property type="term" value="F:lycopene beta cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017825">
        <property type="entry name" value="Lycopene_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03462">
        <property type="entry name" value="CarR_dom_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31480">
        <property type="entry name" value="BIFUNCTIONAL LYCOPENE CYCLASE/PHYTOENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00018909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG2183492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="521" mass="58860" checksum="A18C8F4B224082BA" modified="2022-01-19" version="1">MRWKLPVLFIDPRLSRHAQMSGTLVPCSIFLVIGAYFWNIAIPATSAFYGACILVYTMPVLAVLWSGAGLYIVRRAVSVSLSIIVPTAILCVIDVIAMRAGVWHINEQTSTEIFPFPDLPLEELAFFLLVNTVIVFACCAIDRANAIIQMFPYIASTDPDVQLAMQNPFSIPYLVALLKCFAYPDYRLPSEPIEDLKVSLLVLFKASKSFNTASTAFSFNIRQDLGTLYGFCRMTDEIADNESDSPDRQRKMDTLIEFVNDLFSAKEWGLVTVTPDYIDWAKYEHLPEEDVACYRAVSRMAHFLPKKPFEELIAGYQWDISGQTVKTQDDLLKYCTFVASSVGDLCTAVIMYRTGQGNWRLEQNRSEWITHRAREMGQVLQLVNIARDIVTDSQTLGRCYVPVTYLTNPTQELELLKTGKARHIRDGNLRTYALRILALADKLSNSGSRGIDALPMEVRNGVRAACQVYSSIGIKIRTAQGYPLRAHLNTWERGWVALRCLYGLHGQSTSTRSRMDIWKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q085</accession>
    <name>A0A8H7Q085_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trehalose 6-phosphate phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007271</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Removes the phosphate from trehalose 6-phosphate to produce free trehalose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23420"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="EC" id="3.1.3.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.12" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q085"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000052">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF123">
        <property type="entry name" value="TREHALOSE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2182341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="304" mass="34226" checksum="0F7B4B9B03142C9F" modified="2022-01-19" version="1">MSPTNSKIIGPKITSNLRDIIAKSPTLSPSACTTTPPLNLDKLTDKYRHSSKRIMFFDYDGTLTPIRSRPDDALPSEDMIAYLKALCKDQDNTIWVISGRDEAFLEKHLGHIPNLGLSAEHGCFIRDPGSPNWVNLAEKIDMEEWKAQVAKVFQKYTDATPGSFIENKKCALTWHYRQADEQLGLAQSKECHRQLEEEIIPHFPVNVLIGKMNLEVRPSALSKGEIVNTLLRKHNHVDYIFCAGDDQTDEDMFKSLRESQIVDQDATFSCLVGSNRSETQANFYVPSPAEIVNVLNVMHLAVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q094</accession>
    <name>A0A8H7Q094_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_006534</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q094"/>
    <dbReference type="OrthoDB" id="10251073at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="322"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2183528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="52312" checksum="96E2C60E9AC9B71C" modified="2022-01-19" version="1" fragment="single">ILRASDLSVITAERVRTLLEQEYNISLTDQEKSVETLVMDCFYDLQLQQSSTTMSEPSHNQESDLMPSTTIETPGQVDISEEGKLMVNMQIPDYNDFAMMGSFSMDNTFSMATTSQYTRYPNPINSQSNFAEIHNTSYSFVPQNQSNQPGSNPSFHSHALNLESPSQPHHASHPAATSYPSQVTPSYMPYYQFQPSFDQLNSKTGFATQHYFAGTSSMPQQPQHSTPTHSQEYRIQQMKRQQDGTLVNGHPYQLHTPNVQQRRFDNGYLRNEQSWPSTVAKLRQMNIKTNIKKKAGKAKKKRRTAQVNNDPNAPPKPKRNTGLNRPLVLSAALGAFIGCPELSRPEVVKKLWKYIKENNLQDPADRRYILCDEELKKIFTRDRVNSFAMNRDLSAHLTKKAESSPTAAATPEEAESNYTLCSSSAMTPQTPSVSCEEIESSGEKVEELNAIDLDDLVQSMTSVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0E4</accession>
    <name>A0A8H7Q0E4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0E4"/>
    <dbReference type="OrthoDB" id="10419350at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="124" mass="13577" checksum="5648F1CB19DFC562" modified="2022-01-19" version="1">MSRARRTSSAGSEQDTYYEVTISSSSSLASPKQPSPSYDYNSQYDMSCNGASEWTPFYHYVSPAAGKELSHSIRSVPFFSPANPICINAPPMCPISTTTMTCCVEENGRNTRKAITPNTPYQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0E7</accession>
    <name>A0A8H7Q0E7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_006239</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0E7"/>
    <dbReference type="OrthoDB" id="5563754at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058155">
        <property type="entry name" value="Skg3/CAF120-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25381">
        <property type="entry name" value="PH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="157"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="500"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="658"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="783"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1141"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="545"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="688"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="785"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1147"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1180"/>
            <end position="1203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2183235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1203" mass="132736" checksum="E25FC14CF74AFCED" modified="2022-01-19" version="1">MSEFSPRPSVSRSSGFDPHVNNLSSQARDLSIDTNIPPRPGPAPSPAASFSSRDSRIIYAERYGLTPSMSNLNDMGDDEDDSDDDQPLRPMVPPKHDMPDQIGRRGSRPLSVRNVAPASSSRPPVFVKPAPQQPPNLAIAPADMQSTLRLYESFNQKVYFEGYLQKMNDLTADGKPVVDRQWTQWYVELCGSVLTFWDAKDAKENPETGEMEITSEEPILPTYINVTDSSVDIVGIFAYDNPARENVFVLSSAGSNRFFLQASNQPVMNRWVCAIRLACYEMTRLQEIYTRNFLARPMWADIMEKQQGKVEGWVQARFGGATEWQRYWVVVTDKRDEKRLWGKKSVASRGQLMFYENRKSKIPIITVVNILCAYAIYPENPKLIDFGTLLKVEGSMYASTANDTHGGSANAFALLMTSSNKEMVQWLMGIYDAFKLYGRPARLISDANNINSLNFAEPVFGNQSRLFLEVGEIEHINVQNETLLDSKIAFAGVLRTKLEHQNRMPLPPPHMAGRRSSSTLLSNVTPPKDYASQGSFESSPERPRPSMISSRSTSSMRASSIGPPPPQPSHSTASFRNGGKPFNNGKRYVADSSDESDNGKGDDEEEESEDDDDNIFRRVVPAAAPPPPASKENVVASPTLLTDAAAPQAGLLNISDLGEPFSLSISPQTSSPEVEEPIPAPPAKTERASSFQAASLTSRSAKNAPAPQAPVHQPKPDSPVQKYEQPIFALPMNTTKGEDTTDQLTRQAVLNATARVLESGSNSRASSINNGSVIELPTNKKTMKPASSLSGSEPENAYSVVSNQDSEDNSPIGNTSPGFGYQRTSTMKGNMTPPQMQKLKGYGSPGMGGPDFEQQQQQMWETQSMMMMNQRNMYMDNDDNQSHSGFYAGGRMPMYPRGYFPEDDNRSMYSNMQGGEGPPIPVLGDNFARSNSLLDQYQQEQLTAREQEEYARATGQPLIQVPHKPPEPSTGLLGLITQREQDRKDGSKAKERVSMMQAEIERERMMERERRMLEQRQQQQQFLQANMMANPYAMGMMGMNMQMPMMDPRMSLMSGMSGMAGMGGGMNGMNGMNGMMDPRMSMMSGMGMNPMAMGMNPMAMGMNPMMLDPRMAMMNNPYMRNSGYAGSMYGGFGGAGSVAGSRYGGPVEEDDDDDEEDNIPIGKVANNQDIENKNLKPAPNSNARDSHSSNSSSNRSRQSSNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q248</accession>
    <name>A0A8H7Q248_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_000635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q248"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2184722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="40917" checksum="6B94C240B4FF18F9" modified="2022-01-19" version="1">MSFTKGIPSFPENHRLPVMPSPNSNNAEQLADFCAFVVPCIWGDGWAKLGTSTVDAKRYNAFRTFCKDMINATQISSSCILVSLRYIRVLRSCYPSIKGSVGSEFRLFTTSLILANKFLDDNTYTNKTWSEVSNIPVSELNIMEIEFLSALDYNVFVSEEQYLAWMSECDYLISMDTRRKYRPMKTPSSLLGKANSKSSSMRSAAGGKIIGKSTLPPLVHSISQPILPFTSNTSSLKRSASAIQPTPTKRMCLPNTPPPDDMLQYNVLPPLVRSRTPVPSISQFYGSRPQTPIYTPTLPVCNPYVTVPSQTTVASRYTQQYDHQPIVPTDKLYSWTSSAMNPPMYFRPQPTLHYRQQHGPLSLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q278</accession>
    <name>A0A8H7Q278_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">propionyl-CoA carboxylase</fullName>
            <ecNumber evidence="3">6.4.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_000375</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57327"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23721"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.3" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q278"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="UniPathway" id="UPA00945">
        <property type="reaction ID" value="UER00908"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041265">
        <property type="entry name" value="PCC_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006367">
        <property type="entry name" value="PRK08591.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18140">
        <property type="entry name" value="PCC_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="17">
        <location>
            <begin position="66"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="16">
        <location>
            <begin position="185"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="15">
        <location>
            <begin position="664"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2184466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="747" mass="82225" checksum="14DCEB5BD8ACC391" modified="2022-01-19" version="1">MLPRIVSSAALRTAVASTCRRAPVLMVRRTPSVLPLTRRLPTRSYVSCSKPAREEYVNMVKDYGKTFDKILIANRGEIACRVIRSAKKMGIKTVAIHSDADANALHVRLADEAVNVGPAPTSQSYLSIPNILAAIRQTGAQAVHPGYGFLSENAAFVKALEAEGVVFIGPSESAMADMGDKIESKIIAKASGVNTIPGFNGVVESIEHAKTIAAEITYPVMIKASAGGGGKGMRIAWNDAELVEGYKLAKQESLSSFGDDRLLIEKYIDNPRHIEIQVLGDKHGNVIWLPERECSIQRRNQKVVEEAPSVHIDPETRRKMGEQAVALSKHVGYSSAGTVEFLADSQRNFYFLEMNTRLQVEHPITEYITGIDLVEQMIRSAAGQKLSIKQEDVGIKGWAVESRVYAEDPEKYLPSIGRLTKYIEPRDDIGNVRCDSGIVEGSEISIYYDPMICKLVTYGQTRDQAISTMQKALDEYVIKGVTHNIPLLREIVSHPRFQSGKISTKFLAEEYPEGFKGTKLNAEDVLDLASVSSVLWAKREMGKWAFTEGQGGGLSGKPPSEWSVWVNVSGGQNEDNGTRFTIRRLNNDEFELETPEHGKRVVSANWPLETPLAHALFKETGKHLTVQYLDVLPLGFKLQHLGSKFDVTIQNERQHELSKYMIEKPKQDMAKFILSPMPGSVVSVAVEVGQTIAEGEELAVVEAMKMQNVLRAARAGKIKKVNVQPGTAVAADEIIIEIDDEVNTATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2C0</accession>
    <name>A0A8H7Q2C0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import receptor subunit TOM40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_000755</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2C0"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2184842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36456" checksum="67CB2EDEC1DEFE1C" modified="2022-01-19" version="1">MSVPAYQPYSPLGIPQKQQEKTQYAAWNPMGWYSSINAYRQRLGLPNPGRFERLHFETKDTFLNNYIFDGAQANIIKELSGNFHVQHQFSLGSQVAPPMYNFMAGYTTERTMMQGTMDNDTNMNGTIRHMWSPSSMTKVVGQFTNTPGHSMIQLEQDYIGSDFSFNVKAMNPSPVEFTGIYMASYLQSLTPKLAVGSEFVLQRPTTEIEESMMSVVGKYTGKDFIATAQFQALGVVQASYYQRINEKVDFGVELNLVAQGGRREAVATVGGKFDFRQATFRGQIDTTGRTSAVLEEKMAPGFSFLVSGDLDHMKGQSKFGVGIMLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q356</accession>
    <name>A0A8H7Q356_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coth protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q356"/>
    <dbReference type="OrthoDB" id="2387105at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050">
        <property type="entry name" value="INNER SPORE COAT PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050:SF1">
        <property type="entry name" value="INNER SPORE COAT PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034602950" description="Coth protein-domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="533"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2184961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="597" mass="65177" checksum="479AD4DB2812E404" modified="2022-01-19" version="1">MKAVFSLAALAMAANAASVTFRVVAPGANSVQVSVGGQSTTLNASDPDVPYYTGSANLDSGATYKYVMDGQQEPFDRSLDASRNQTMNDFFGREITYANLPTLPWPIQGDRWSRMGSKTPVFDDNYFPTIFITGDDAAVQNLVANVPAAKIPVKYTFVGPDEVKVFNNCSFGVHHPGGKNNEAKQTWEWSLPEGQDLYGRTWMKARNMEQDPTQIREKLYADILYALGSYSNQANYVRIYINKDGYGTFNLVDDVIQYSFINAVFYGNATKPSAFGPLYDGGTGASLSYAQESEDDWGSWTPNAASPEPASYLSGVSKAVDDMNPADDASVQNFTSTQLDTDDFLRFMVMEYLTGSWDGYWMMQTNDGAYQDPTSKLWYYLPQDFDGTFGLNLDVPLNFVNQSYTTFPTTYPNATLINKLLQNPTQKTKFETYLKDTVSILFNNATLGQRVYAIQNRLKPEVAWDRNITQRSPGVNYHWTYEQFLENVDQPVNGVGGGGAGQWGVMQWIQTKSQLVATEFNLTLPTQPVNGPNTTASTSNGVSTASSSASSSGTGKSSAQNSGDASSTTTSAASSSNANMVMVLATAVAGVFAASMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q360</accession>
    <name>A0A8H7Q360_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_000971</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23360"/>
            <dbReference type="Rhea" id="RHEA-COMP:14604"/>
            <dbReference type="Rhea" id="RHEA-COMP:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140573"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56560"/>
            <dbReference type="Rhea" id="RHEA-COMP:14606"/>
            <dbReference type="Rhea" id="RHEA-COMP:14607"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140574"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="10"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000092">
        <property type="entry name" value="Glycogenin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="711"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="756"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="979"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1065"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1143"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1460"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="642"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="537"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="985"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1079"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1092"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1112"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1143"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1163"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1192"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1213"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1239"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1266"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1284"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1307"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1492"/>
            <end position="1503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2185058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1503" mass="169026" checksum="DF5230C0E3E05BC4" modified="2022-01-19" version="1">MTRAYVTLVVTDRAAAGALVLAHRLRDLHDGRDSGQKLVCLVTSDVSANTEHALATVYEVVRVNIPRGKAALNLHLLGKPETALSLAKIELWKLTQYEKVLYLDPDVLPLRPIDELFEFEEMSAAPDIGWPDWFHTGVFVANPNQTTYAALKTMTEQDKVYEAGDQGLLNEHFEDWSTSGPSHRIPFAFNIVASAIYSYAPASKEFRKDVKMVRFSDDEKPWDWVTFQDGRVFPRGTSTSSSVDFAQLWWDTWDRHNLQQTAIAEFLPQRDPLQAPELSNIGALKNAWDTSAIIEIADHSDERTFVHPLPPLPPITFQDEVWRGEEQHNQEQQSYIYAHGHHQPAEHNEHQEHHGEQEQHENYEQQHVHAKAPEHDIANVNTRHHEDIQEQEYHHHVPEENYDMLNWNPSWEEPPQNQSAVDIPNLQIYGNAWDNPQSHHQVWIPPQDLPPPPPSVDYHHQYNHTPANSQKEEQVPDWQHDPVFPWEEKRELRHMPTRIWQDEQELEKRVREEEEYRRIEAERAAAEAENSAIASQHQEHSHYQDQHNHHAGDLSGKQEVIQQALEVENDIIEQTISETAGHPQEQPSTLDQPFVSVWDQMPDIQKYLARIGVHDAFKHSEYQPLTVDETEEVVETLEQQEFVDEEEEAEEFEGSAEEYEELKEEYEVDEVDEEKIEDHTKITKPVHLDIDPPPTLAQSWWGEPFAIDSMPTTPLIGKSGARSPMLPMTPRLEDDDWDDRDLIPLPLKRTSKLFQGDLPVFPESKTPVESKSPLEAPNSDPNVSPDDNSLKQKKKRRIKKLRKLFADENDMIRKTPFASAATTPTSEKGFILPPVEVEETVVETVNLPRPDSFGDYKIEWASDLLKDHEGVATPARTPSKEVASNSYFDVAPATSPAPKKKSRYNIYASRSTWDPLHALKSLRASGEKLLIKTKFESNDPEDSDDEYAPAAYYNNDDEEDLGVLGLTFPATRVKKEYAMSKLEDSPPNDSVSVSPATPTAKGMSMNLTDKIMQEAVERRINTDIALHEAATSLVKSTEAAYNDDGYAMSPTTEEFPNFNVSATELEMSQDNSSRRRRSTAGSEAQSENKFTLVHEEQEKEDGNVSNGAPNQEPHDTSDPVHSDIIQAATDKLKQIAGIDWEAETKEDASHMEDTKNWVFAQRSEGVTSTASTAGTETAEEQPADDDKAGEQEVQSKFSGDVTATEQPAQLPKFDGDVGKNDPEVAGTSTIPESKDDISTDSTESGSTSNVARNDFRSNAPGQLSFPKDDSGEADPEAERRDSLKTPTQSSFAVSTLAHQSEDWPAQDNASESTSSLPDDVEQNLMATVETLVRKVEANEPAIGTTESSAPTMDRETSLSHSSIDGAESARSHFSNSTEEQLEVPGEGTDIDDTSSDTQWLSATEGDHGSESGTSVDWFSVQSFDNSANQSEDEDHQLHRGSDIHRDFLRRFVEHSDLRRSDLQHEISSLDSGAPYLGTDEDSTYEDPLVSDESASTTEVNEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3B2</accession>
    <name>A0A8H7Q3B2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3B2"/>
    <dbReference type="OrthoDB" id="259708at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052763">
        <property type="entry name" value="DnaJ_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44825">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44825:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="52"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2184765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="317" mass="35315" checksum="A7F40F4A5A77608A" modified="2022-01-19" version="1" fragment="single">MQYVYNSFFTQSTTALQPACSRSVSTKQPIDTISLHADKRYQLVDEILTATTYYAVLGVTKYTSTEEIRRAYIKRSRICHPDKFVPPYKKATEAFQRLSLAYETLSDSGKKVIYDISGTGNTPMFANAATVDGNETLQALLKQLFVEMMDGEFNTMRSFMIGLSRSNPSIQFTEETIVNIEISLRRVREMILSTKKYFKVVQFELMRLYELQHEIRSLSYFDLMRRMRLTVTMFKVILSLPIMINLVSKGQISAPPSMSASTSTSTSTSTSSCAESSSASSAPSSSIPESNNDGGGILGDRVESALRVAVGFLDVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3T7</accession>
    <name>A0A8H7Q3T7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TATA-binding protein-associated factor mot1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Modifier of transcription 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_000933</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252227at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17999">
        <property type="entry name" value="DEXHc_Mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000009">
        <property type="entry name" value="B-TFIID TATA-box-binding protein-associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000428">
        <property type="entry name" value="TATA-binding protein-associated factor 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044972">
        <property type="entry name" value="Mot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044078">
        <property type="entry name" value="Mot1_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022707">
        <property type="entry name" value="Mot1_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498:SF1">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12054">
        <property type="entry name" value="DUF3535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="1329"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="1681"/>
            <end position="1838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="169"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1040"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1040"/>
            <end position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2185020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1903" mass="211695" checksum="7AC7FD5BFED6D8EF" modified="2022-01-19" version="1">MATRLDRLVLLLDTGSTAAVRQTAAQQLGEIQKQHPSELYNLLSRVIVHLRSKSWETRVAAGQAIEAIAANVPEWDPPEEMKTEDSNSPPPAETHDVNKLTFATFDLSSVLVHGRLLLGSAGKEYDIDMSDMTPQERLALQRKNLKDRLGLGSQFMDVDLLDDMDVSSDLSKDAKSTKQPQTPPAQKFVPETPPPPPTPAVSQINMAGLSARERNMLKRKIKQDAKNKGKDKVRMLDLKSQRQPAEQADTKAFATPSPVKVENDANMENYDITPQPQSDKIVVESKVPPPVDTVAAEGPRNEWPFETVCEHLCMDLFDPSWEIRHGAGIGLRSVLKNQGRGAAKAAGLSIQANEAAHNQWLEDVAIRLLCLFILDRFADFVSDQVVCPVRETCSQTLGVLLQYMNPEAVKQVHSVLLQLIKQNDSAFKQKSIWEIRHAGLLGLKYAMAVRKDLVDILMDGTTDAVIMGLCDHDDDVRAVSAATLLPVTVEFVNLSSKERIRTLVNTLWDCLTDLKDDLTSSTGAIMDLIAKLFEQQTVMDIVREGHSLGTLVPRLYPFFRHIITSVRIAVLNTLITLLECKTGNEWVEENVYRLIFQNLVVEERDDVLARSIKAWDVITNTHYVDQQAILGGTQNRLGSWFEVTMTPIGQQLEVATHFYKPPGAFGSGGTVTAEAKLANGRKDKKATSDDDKGGYNLDAGMVLQDFSLVTPEKVMRGRVAAATALGKIMSIWPDETMEMSYYDVLITLLSSSWASKRQLAAIVIEEWAKAVMKARYNVKHHGDGDQIIVLAEKISFADRLSKVTVSSLENDGVMQVVPEQQQQQSGLPPGYYYELVFVLKRIRGESQSLLNAFMNEGKVPAAKIPTLPALVVGEAPIGPDAPEEELFSVETAGWVADACFNSLINQIGKVRGKAAVVTSLEERRKRIITSIGFYEDTKQKSDVNILASLAGAVIALGVLPTKLNPVIRSIMNSIKFEQNHEFQRRSASTLASLFALCSYAQGRVNPSDKIVKNLCTFLCCDPQLTPVFEDNQQLNGIQSLQKTDAPSNAKSSKDAQTLNSHLSEPELMRRGAETALKELCDRFGGNVFNIIPKLWECMAGRLQVTYGEDSPAVKDINAADETIVNDPTLGQEIVDALTVIRTVLPVLHETLASQVVSIAPFVAKSLQSRYSVIRFSAARCLAVICDVITVQGMRIIVEQVIPLLGDTRNDSKRQGAAEVIYHLVQLLDAKILPYVIFLIVPILGRMSDPDDSVRLVCTNCFALLIKLVPLEAGIPDPPGMSQELLAHRDEERQFLSQLMDPTKIESFSIPVKINAELRKYQQEGVSWLAFLNKFHLHGILCDDMGLGKTLQSICILASDHEMRSAAYVQGKETSPCPPSLVICPPTLSGHWYHEIKNYTNSLKPLMYTGGPAERKRLRSKIQDHDIIIMSYDIIRNDIEDLTKLTWNYCILDEGHIIKNGKTKITKAIKSVRADHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKIFNERFGKPILASRDSKSSSKEQEAGALALEALHKQVLPFLLRRLKEDVLHDLPPKIIQDYYCELSDLQKTLYEEFSKSQAKNTVEHELEDTEEKEGGNKAQHIFQALQYLRKLCNHPLLVVNERHPEYTKVMQRLEKNNASLHDIQNAPKLLALKQLLGDCGIGADTNDAETDPAAMAAGAVSQHRALIFCQLKTMLDIIENDVLKKLMPTVTYMRLDGSIDATKRHDIVQKFNADPSIDLLLLTTHVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRLITRGTLEEKIMGLQKFKLNIANTIVNQQNSGLQSMDTDQILDLFSVPGGASDEKAHKKKDVEGDAVKKGGPKAILDNLETLWDEKQYEEEYNIDNFISNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3X0</accession>
    <name>A0A8H7Q3X0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_000756</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3X0"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF99">
        <property type="entry name" value="RASGEF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="338"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2184843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="642" mass="71595" checksum="9182A58986CCF8E6" modified="2022-01-19" version="1">MAYQCLQCAEVVSNRASIAEMPSNKSYVKSSISKSPPPVPPKPKSLTKNLATQPSIGISNTKDSKAFQDKGHDVSKRQRLPHLQLINAQDLEIDTENTLSPRSKLLGRPSTAFINNNSKNVSVVPQLAAPSPISHGSVATLRRKLDGVIYRRASSPNLGTSASQATINSNRRGNSIKNMLTLPHLSRNESKFIDKEEIALLPSTPVEYTVPFFLFDNSIDSSMMMEAQTSQDENLAIPGSNKTSANIPHIPIPPLQIAYKELSGQTGNVKSGWEKERTVKNLLEVKNEVDEGQIQRLEKLEFDVTQSKTSAAEHRTLLDQLRTLHVSATAVQSILQFRPQLVAYQLTLIDSAIFRSISTNALIEHSPKTPHPSIVASTDFFNYLTRYIEHSILLPQEASVRAQLVNHWIKISSKCLEFQNFQTLKAIVSSLGTPPIQRLKRTWSFVPKKNLTRLEVLNSLMSESCNYRRYRERLGISLDGDEKNIQGLNVSKPIVPFLGTFIHDVTYITAFIKSYRGPSPIASVSTPTPKQSSKITAKLKFESGLHPTDISAAEKLLLEQDPRFVELIRKFEYYQSLPDFKSNLPANVVKSLHKSRRTRLSDALKNASSNKLGLQNAEIDKEDLPLPMQQAIVTQYLVSNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3Z1</accession>
    <name>A0A8H7Q3Z1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol-phosphate mannosyltransferase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_000537</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3Z1"/>
    <dbReference type="OrthoDB" id="2014333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013174">
        <property type="entry name" value="DPM3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433:SF0">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08285">
        <property type="entry name" value="DPM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2184624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="92" mass="10311" checksum="C4B24139EE81628B" modified="2022-01-19" version="1">MTRVTEVATTAAIIILTYLALVFELLPVPQTFQEEIVPVLPWWALVSFGSYCLGTLGWNVMTFGECPEAYNELMREIAEAKDDLRSKGLTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3Z4</accession>
    <name>A0A8H7Q3Z4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Siderophore iron transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_002132</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3Z4"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF92">
        <property type="entry name" value="GLUTATHIONE EXCHANGER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="574"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2185697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="594" mass="64616" checksum="C4603C575DA638FC" modified="2022-01-19" version="1">MTTLDEHRSPQLNDNENYSEPASTVERSISLDSRSPGVRRIEAISTSFTTVSMTLLFVGVFLVSYAYGLDGQTRGVYQTTATNSFEVHSLLSTLNVVKAVIAAAAQPPMSKAADVFGRFELVTFSAFFYVLGTVIEAAATNIETYAGGQVLWQLGLTGFQLLFEVLIADLTTVRNRVLFSYIPALPFLINAWVSGNVTSAILANSSWHWGVGMWCIIIPVTSIPIYIGLIMAKRKAKRDGKLEGLELKYDRSSARKGMIWFFWQLDVIGVILLTAMLALILIPLTIAGGISANWHKGDVIAMLVIGILCIPAFAVWELKFARHPCVPFHLLNNRTILAGLMIAMMLNMCWYLQGDYLYTVLSVSFDESVISATRITSLYSFASVITGIIGGVFIRYIRRIKWVAVTGTLIFISALGMMIKYRSASDNGHAGVIGAQILLGIGGGLFPYPVQALVQASTKHEHVAMITALYLTTYQIGSAIGNSISGAIWTNTLPAQLAQNLAPLNASLADIAYATPFTFIAEYPMGTPERTAVIDAYNYSQKLLTITGTCLAIPVIIAALMLGNPRLGDTQALPDAETSSGNHFDEQLTDVETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q401</accession>
    <name>A0A8H7Q401_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_002512</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q401"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02336">
        <property type="entry name" value="ZZ_RSC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041984">
        <property type="entry name" value="Rsc8/Ssr1/Ssr2_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF41">
        <property type="entry name" value="BRAHMA ASSOCIATED PROTEIN 155 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIRM" evidence="10">
        <location>
            <begin position="43"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="11">
        <location>
            <begin position="260"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="9">
        <location>
            <begin position="265"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="373"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2186074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="559" mass="62678" checksum="00CAEC10D1C0DCD4" modified="2022-01-19" version="1">MSVEVSPKVATPVTPTTEIPSSTVDQPVDEAAHKYLLEQIKEATIPHYAHWYESDNIHEIEKKSLPEFFSGKNRSKTPIIYKNYREFMVNTYRINPKEYLTVTACRRNLAGDVCAIIRVHGFLEQWGLINYDIDSKTRPSTVGPPFTGHFRVTADTPRGLQPFKPSVAPIHTSQPSGKGTSPLEMNVELRQQVYDSIESGSSSHAIVCFTCGDDCTALRYHSLRTKGLDICPRCYNEGRFPSTSNSGDFVKLEPNKFKHTTQEDWSDQEILLLLEGVELYDDDWNSVAEHVGTRSREQCIMQFLQIPIEEPYLSHSKEDDPVKDITRFHRMPFSQADNPVMSIVTFLASTVKAEVAAAAAASAIKRIEAKTTKGSDDAMEVDTGDETNKMDEDEREQEVPSEGNLPKNEIEKVASVALGSAAAKAKVLADNEGREIQRLVNMVVETQMKKLDIKMAYLDELEGLIENELDELANERMQLYLDGLAVKNATHYLNREIGDKTVSEAVDTGLTYEKVQQIISEHGHTENYKFVPVNASSEDQLQLPHMAEGAGESMTWLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q490</accession>
    <name>A0A8H7Q490_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMMECR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q490"/>
    <dbReference type="OrthoDB" id="24630at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00296">
        <property type="entry name" value="TIGR00296 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2185023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="207" mass="24243" checksum="449CE190353F3F34" modified="2022-01-19" version="1">MAVSEKHCYYCFDVLAAYFEGRDPILPEFDNSEYPLFVTWNLKKHGSYRLRGCIGNFDPMPLHTGLRQYALTSALQDRRFNPITYKELPHLSCGISLLTNFEKAKDYLDWEIGLHGIWIEFENDDGRRRTATYLPDVIPEQNWDQIEAIDSLLRKGGFRGRITPAVRESIRLKRYQSSKLEITYEEYAAYLEKNDVEQFPSVLKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4A4</accession>
    <name>A0A8H7Q4A4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_000320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4A4"/>
    <dbReference type="OrthoDB" id="2626014at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF16">
        <property type="entry name" value="CARBON-NITROGEN FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="278"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2184411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="541" mass="60361" checksum="15730378D3A08204" modified="2022-01-19" version="1">MPVKYPSKSDLKYQPLLLVIFVLSVFGVGYQSIPVFTWLFYPVALYYTRQSWWNLVFFFIFNLFGNALAILGSFNLDPVPGFASVGLLIGLAAAVNVLIVICFAVDRLAYLTNSSPLRVYTFPLFWTGVWNIFAWYSPLGDFFTFSQAGMLWGSFRQIASFGGRAMLDFFMAWCGTVIVETWFTKQGTHLQTPNADLDQTFSKPVDNDYSEIDADMSKPKQSLRTTIRLHLTPLAIFCLIFATLLGYGGGQASIISGSFYQKSYEGYITRDVIRAGCVIGNTDGTGYSPADRQYWFDQSVQLAKDGAKLVLWSEETSQTFNSTDEQQFLDQASAVARNNSIYLAVLYINNIPDTIENLMTLIAPNGTILLTYSKAHPVVGVEDQPPGPNVLQYVDTPDLGRVGVGICFDYNFPSLIDQAGQNQVNLMLQASWTWGPLGTFHARGNSLRAIENGFTMLRCGSQGMSGVFTPTSDSPYQQQFATLSNQTLMFQVPRLPYVRTTYTVFRGAFGWICLALGLLITIYLIISPLLHKILRKRSATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4I2</accession>
    <name>A0A8H7Q4I2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4I2"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815:SF1">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="45"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2185733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="263" mass="29115" checksum="4E993ACE4829D0A1" modified="2022-01-19" version="1">MSYLGKSDKYVRGVSFDNMTDKDLPDYSFTLRGKSKGFQRTRRSRTFMVATDLANYSEYALTWANEEIMDSGDELIILRVVTVDMTDKRSNVQALLHHEENKARENANAVLNKVLDKESDIEISVVIEFVIGKVQETIQHMIAMYQPSMLIVGTRGLSDFKTMLLGSISKYCLQHSPVPVVVVRPDDKTKKMKKNKNRLSSLMRKGAKSPSSSEENGPSVSPGLDKGMNKLSVEGYFGSRSQSSSPATSPGPSPSSTSSVSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5T7</accession>
    <name>A0A8H7Q5T7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="12">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_002240</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="12"/>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5T7"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.210:FF:000001">
        <property type="entry name" value="Acyl-CoA thioesterase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025652">
        <property type="entry name" value="TesB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02551">
        <property type="entry name" value="Acyl_CoA_thio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="14">
        <location>
            <begin position="424"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2185803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="871" mass="95109" checksum="895481C875113D79" modified="2022-01-19" version="1">MNAKQPTVKVFSRPVLEDNGSKATAKLPAAIVNAIEVNRIDECLYNSRELWKPIGARGVFGGQVVAQALRAAAKTVDPSFYVHSLHCYFILAGDNQIPILFQVDRLRSGKTYATRVVKATQRGRAIFTASVSFSLDEPGPMLHHQPRMPDVPPPEEIPTEAEKVNAMLKDESLDMSQEEKDKAVLRMAERAALDTRQIDTHGKEKHYRWIKTQGTVDDDDRTIHACIAAYASDTGLIGTAARIHNLKSNDIGLMVSLDHQIWFHAPFRTDEWLLYEMVSPTTNNGRALCMGQLYTRDGRLVATTVMLNSAIRHSLLRQARRNAQQVARRAASTAVPTAPGKPWPIVIGAAAASGAAGYWYANANASTSATPMTSAQPAAIANKVDAKAIQTAFTRLQQVLPAEHVTVDQETLQFHGFTTNSYHNEGAPNIVVYPQSTDDVVKIINIANELKVPVIPVAGLTSLEGHFSAPYGGICISFGEHMDEIVAFHEEDMDIVVQPGVGWETLNAFLKPHGLFFPLDPGPGACIGGMVGTGCSGTNAVRYGTMREWVLNVTAVMPDGSVVKTRQRPRKSSAGYDLTKLFIGSEGTLGVVTEITLKLATIPKETSVSAPPKNKFPKNSNQYPVAVCDFPSIRDAAAVVPDIMKAGIQVGAVELLDEVMMKAINMANPRLGYEEEVTLFFKFSGPNKTQVQNDIKLVSEIVNKHKGGKFKYAKTDVEKEELWEGRKVALWSSALLKPGCSIWTTDVVVPVSRLPDLIEQTKQDIATSFLPCPMVGHVGDGNFHVFILFDRDNEKETAEAKRLNARLVDRAIELEGSCTGEHAVGIGKKNYLNKELGVPTVELMRTIKAAVDPNGIMNPGKILPDLEKPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6S7</accession>
    <name>A0A8H7Q6S7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Photolyase/cryptochrome alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_002592</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6S7"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.579.10:FF:000003">
        <property type="entry name" value="Deoxyribodipyrimidine photo-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF18">
        <property type="entry name" value="SI:CH1073-390K14.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="9">
        <location>
            <begin position="46"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="568"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="579"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="322"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="364"/>
            <end position="371"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="462"/>
            <end position="464"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="472"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2186154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="608" mass="68667" checksum="2A1846154AF4311A" modified="2022-01-19" version="1" fragment="single">MSPSAANKSLDNRHRRTSSGSNSPNKRPKIESVEHDTTKANTSKDGNVLIWFRSDLRTNDNPALAQALELVTSRRNGGPESKSATAIAIFIMSPKEFKSHDVGAVKLDFILRNLRELSTALWDRYRIPLLVKTSSSAANVISDFKQLCKTYKVSDAFANQEFEVDETRRDNKLSTVLSDENINFHLLQDQCVVKPGELKSKSSNSVYTVYSPFKRRWFEVVKGSRDKYLTEAKALTQFKAPFNTETNLKVIGIDKPDEIPHVLEGFELDEEKRKHLSELWPAGEHIGLENLNKFCSSKSKTGAVAISKYQTDRNFPNLEQGTSRLSPYLAVGALSTKQCIVKAMAANGGKLDSGNSGIVTWIQELIWRDFYRHVLVGFPHVCKNKPFKLETMNIQWIFDDDDFKAWCEGRTGYPIVDAGMRQLQKTGWMHNRVRMTVASFLTKHLLHNWQHGEKFFANSLIDGDFASNNGGWQWVASTGTDAQPYFRIFNPYSQSEKFDPDGIYIKRWVPELAGLKTVAAVHNPHSVLSKKEIAAMGYRDTPIVEHKMARERAIEAFKLVLGKGMKIPNPKSSQGYGNHDYEQMETKGNSEKSKDPPAKASRKGKDKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7H0</accession>
    <name>A0A8H7U7H0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_009131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7H0"/>
    <dbReference type="OrthoDB" id="10255512at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="624"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="665"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="199"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="674"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="993" mass="117271" checksum="D3FD59E71584305F" modified="2022-01-19" version="1">MNRSDGTPNKRIGRAFSNASYHDPSLLSNPRKRPLPPASPLAKRRLTTYDQNSISSPLKSKTDGVSLTKENHAGQLSAAQLQSLYDTLETRTQESKLLRKQISLKDKELAGLKSELVDVSDLLTEIERNVTQTPGSLKASVAKAVAKKNNSDSDYRVAQLRQELSKRDESVYIQQKKVESLQELNEASKAEIDRIVSYGENLQTQFDNLALEKKELEGKLEEIKETRDKQIKTLVEELEKRSALLKQYRDMLGNVDEENGELMVDGKRYSDLKMEAEMAQRKLESLERAHRDARESLLHLRNEKSDMEERWQRLHERLDEREKEYEIVEKKAEESEYNLLSNLEKVKVLERKIGEYETELDNITNDRDDLEARRRHLEEELAKRNRQYEQALNAKDEMEEKLEKLTLELESKDELEVEKLRYEQALDDQQRAYQELEAEKRDVEQQVNDQQAAYENVTAQKRRFEQQLHDQQEAYDELLRERDELEQSETELKRRLAESSTSKEAFVTEKRRLEQQLEQQQQAFEDLLNEATELESKERELRIQLNRVSVSGENAEVEKRNLEQQLLEQQAAYEELDQEREYLQRNERDLKRRISELTASKDDLTTEKNQLEQALNEQQRAYDQLDHQKHSLQSKESGLQRQLDDLKSSYEDVEAERRHFEQQLKKQQQAFNHLEQERDSRRSREVDLQRRLTDLNVKADTLTAEKRRMEELLDEQHQQYQQLVVERDDWSSREAELRKQLTRKEMQYKNMEKSLQDKTVVSKQEMELQQKTLTDYKRQLSEARSKLTVANGKANEYEIEIAKANEATRERTLKIGELEQKVDQIKRELEGALSQRRQVAQVIMDLEQRLHAADADKQDAEDRASNMEKAAKMLRDERDEFRKDLDKLKRLYEQQNKQYIEKAKAREHEISLLRQKQNDDTHALAESVKEKDSQIHELARDLARYKQVYQAACDEKNFAERSRDDCIADAQMLKEECLKQIRLLEQRLVHQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U838</accession>
    <name>A0A8H7U838_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U838"/>
    <dbReference type="OrthoDB" id="5590091at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="254" mass="28967" checksum="35CB3407A22031EB" modified="2022-01-19" version="1">MLHVETAFEPHHVPSKSPNVKQDEMQEVYMSSDEETMTSATLSTVAPGESRRDSATDTDMDSGSGDEVFRQFHAGIQSATDNISTCKSTYFFDGGKRFISLPTLGNSNIKAATLVSRMFEQWLENKICHTSEEDRVPILEDSVELSCEDIMNTFKQKGSMRAFHGLSHVWLRIRAGHAYFYHQLEDGQPLLSQDMEDFFQDFPLFVEVSINVKTLDNKRSEHHHQQHCKVLVSMENMGINPGKPYRFLEDIHLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8H2</accession>
    <name>A0A8H7U8H2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosducin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_004644</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8H2"/>
    <dbReference type="OrthoDB" id="10257948at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02989">
        <property type="entry name" value="Phd_like_TxnDC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="23"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2173270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="199" mass="23345" checksum="62E16B5F528A323C" modified="2022-01-19" version="1">MTEVENHQSIEDVEDEESLFKELEEEDDQETYQFREQRVQEMQQELARRQHMIENEHGSYEEIAKEKDVMKLTTTSKYVVVHFCHKDFRRCDIMDKHLKVLAEEHYQTKFCKINVENAPFLVEKMHIQVLPCVMTFIDGIAQTKLVGFDDLGGTDSFSTALLEFKLANAGVIKKKESEIQFASKSKSLYQDDDSEDYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8H8</accession>
    <name>A0A8H7U8H8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Helicase SWR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_001504</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18003">
        <property type="entry name" value="DEXQc_SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000005">
        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF1">
        <property type="entry name" value="HELICASE SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="14">
        <location>
            <begin position="396"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="1015"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="1560"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="523"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="615"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="719"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="865"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1770"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="638"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="719"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="744"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="758"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="802"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="865"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="905"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="959"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1787"/>
            <end position="1797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2172027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1872" mass="212641" checksum="493110D3CEC8E82A" modified="2022-01-19" version="1">MVDQADRHTSLPAEVSRKSNSPGIRRSSARSASSHSRTGAATPAQPARPRSLFDSDGNISSINILNPSGSPAGSTRRHRTKDTETPVKKEPLSVGLRTTSIREAPSTASSTSVRREVAKSRPAPPEPSSQRKKRRKQDPDLISEPESNNDAKRRKPSMAELKSAAKQKRPSLIKAEATEKHLPNPKKPKTRRQPAPAKPLTPIELKREEFIAEREKDLQTVVAQHDATVRELYFLEVYQNMLDYDPAKWKLNRDDRLVQYMQNFDLWSTVTEQLISKTAAGSKGISTRRTLTQRRDSLLNMLQDKVGVTSPQAASKGVVDSSRRITAFPGITAYRRPVREYPTLEGYLKSFVSVEENEDITPEQANEIIEREASLRDRIHNLKQKGGLNKTLQSVLRRQAEPSKGEAHHDILINTVVSTAKLFHNNSKYRKNSAKKVAKAIERYWESLRTQDERMVKEEARRLQRLAKWTAQEVKKKWKVVERVCEARYKELLQEEQAQRGKRHLDMILEHSEQMLGVRMGEISSRQTTSIAPSSDNDTAHINGVDTNTEASVTEDEKNDVASQHSWESAEDAADHYIQDQSSSDDEELGGLEEDMDLPIEELLKKYNYDNHAAGDTASFDESSEQHTDVDQSVEANTADEAESSVMEEESQAVERETLVVERETLVVEHDDEIVEQETQNAVSLVQNGAHLPNDVPDAIEEKDVEYSAQASDEDIMIEQDGESEDDDVELNGLADDADVPIEELLKRYGYTDREPSTDEDADDEEEEEEEEEEEEEEEEEEDNNDETPADPMDISDDEHYNANAVAVAATATATATATATATAQDQPAVAEDSKINELKPVVHNELEIQKIAEAKDDVDIIGADERIPDPDEDYVRHPTDHLVSVDMIGSTDEADDSDRTATEMGDEVTEVSDDEDYQAGVEPVAGDKMLEDHTSSKQSRPSSRHASRQASRQASPDTVKELEARPDQSKEDTSASAPPPTGTTLSTATVKTKVPFLLRGTLREYQHVGLDWMASLYSNGLNGILADEMGLGKTIQTIALLAYLACEKGIWGPHLVVVPTSVMLNWEMEFKKWLPGFKILTYYGNPKERKEKRLGWSKENAFHVCITSYQLVCHDQTSFRRKAWQYLILDEAHHIKNFRSQRWQVLLNFNAERRLLLTGTPLQNNLMELWSLLYFLMPNGVSESMPMGFANQKEFQEWFSNPVDRMIENEQQQMDEASRAAIQKLHTVLRPYLLRRLKADVEKQMPAKYEHVVYCRLSKRQRYLYDDFMGRGKTKETLASGNFLSIINCLMQLRKVCNHPDLFEVRPIVTSFAMSNEIQLIGSTTELLVRHRLINEVDTLRERLNYELFNFDITKNETSMSATAGLCMDDLCADKLFETQISNRHRHIAAFESRSVNRRTYYDLKQHARAMRLSRALGKVGRLEQMNYVNHWRCTSRPQFGTALIDFCRTATANSLTRIHETSSPRHYLEHTNTVEDAVVKYDRRMNNGSDIWKRYAFVTPSVLVRNDRQLIQHDTPMAVQQTFHQISQNDIFHGIRTCLSIAFPDKRLLQYDCGKLQKLDTLLRDLKAGGHRALIFTQMTRVLDVLEIFLNIHGHRYLRLDGATKVEQRQVLTERFNNDKRILAFILSTRSGGLGINLTGADTVIFYDSDWNPSMDKQCQDRTHRIGQTRDVHIYRFVTEYTIEENIFKKANQKRMLDNVVIQEGDFTTEYFEKMDWWKDLPEVAGSQQVSRNAEATTPHVDIEQALLEAEDDETDARAAIAARKEMRMDETEFADTPAQDKTAVISSRSATTSPGPKESNIVLPSESLDTESQMDAGGDEIMNEDLTERGMQLEVGHVDQYMLRFWEREMFGQYLGFGGLPAPDTPGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U958</accession>
    <name>A0A8H7U958_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U958"/>
    <dbReference type="OrthoDB" id="42525at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332:SF2">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="209" mass="23510" checksum="6A4B95C6C9BCF16F" modified="2022-01-19" version="1">MSEKHFTWLNEPASHSTSGSQKSAKDYKIAAVEARSKPTTDFWRKPPSVHRDTGHFYYVTVEGDFHISCIFKGDWKTQYDQAGLMCRLNSQKWIKAGIEYDEDKTFASAVVTSPYSDWSLGEVDLTSGKDHIYLEMQRKAGGIYIRYALVGENEDMSKDPSTSPLRTVNGFTGSDTNESIQVGIMLCSPKSQDGVQVKFKDITIKQISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UA11</accession>
    <name>A0A8H7UA11_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_001476</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UA11"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16461">
        <property type="entry name" value="RING-H2_EL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="392"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2171999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="453" mass="49038" checksum="521E749662579319" modified="2022-01-19" version="1">MGQAFSNTASAPFTNGTSSSDSSHDQATVNDFGPDATAWTSAVSRSELTPSPSTTTTRRVLRSQTSNRSSRRPNISFNPLRYERPPSPASAPSTSSPSPRLLTRLHQRLRRPTSNTSETSSLVSPAASLMDIEPMEPSISNGIFGTPPTAISANEDEDEEETSTAGGSERTALSRLLTQVITTAVLDSLNRPGNQEQEQERTQGVDEEGNGEWIPRHIFTGQGQREVEGRSSDLGSFFRMLRMPTSTFRNSGNEGEEGTSGEGDDHGEGDTMPVFILGYRATRSHSGVGHDDDDQQQGEAAGVGGGSHSGQGRRWIIYIISGTNQPLVGGENNNSGLPASLFGDNPTYEDLLSLSHFLGPVRPVTATQGQIDRIPITVYHKQAMTEMLNDKCQVCLEEYAESQELRMLQCKHGFHKDCVDRWLMEGRNCCPICRGVPVSDTDSDTSTNHTASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UA23</accession>
    <name>A0A8H7UA23_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UA23"/>
    <dbReference type="OrthoDB" id="5596547at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2172343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="552" mass="63638" checksum="DAABD6E61EC83FC8" modified="2022-01-19" version="1">MASEAEKYKAPGINVELECRMIIPTVTDWEDYETLTIPYFRLMSHPTLNVRKVGNLIETKELVCRTNVDNVSIFVSIEKQYHTKLPDILIPRITRKVQRKIIKNKPLTVINCENKVFTLEIEYDISTVEECKDIIKSYLLPMWPAPKPVDAYASEFISKILHGKYCLTPKADGDHVVVYISFDDKSFYITDNGCIVGQRFTEHPKTVMEGEFADGEIHLYDVMIANGEDVTNLPLLKRRGYYPQYHFKDIHVFTTYNSLVKAFKKCKANFSTDGIIMTSMGSYYDTVYKSKSVPTVDFQYIDGYLHLANEKTSNRSPNGDVHLENGKIYEFDMKMNYIRSREDKIIPNYRMPVEVDPLSNIVNGYGIPNLRYHHNYVKLKMLKLLPQTTLLDVGSGYGGDINKWNQFEKVYAVDPELNLRSKPKNVIPLRCTAQAIPDIEYESISMFFVPWDFSILSSVSAKHVMMIVMDNPKTVINDLYSIKVIGDKVHVNIPGTVTAENIVESKVSVDDIDRFMKARKYECIKINYGMKFGSPEEIALSKMYSYLYYKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAG3</accession>
    <name>A0A8H7UAG3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_004375</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAG3"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF18">
        <property type="entry name" value="PEPTIDASE M48 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="8">
        <location>
            <begin position="224"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2174352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="506" mass="56993" checksum="7106BD474DFB8D58" modified="2022-01-19" version="1" fragment="single">RSLRPNTSYYQSCAQKIPKACIRTPSLNNFPILHTQFHHDLLLNSIRKFHTTSPRNVPIIPLPAVLLGLLKSGKLVSLVSLSSKTSLTLLPHSIFRQYRLSTKIFASIPFIGIALLLGVGLDKVRLHFKVILLRIEIIIDHSFYVVLKAPNTDRLRLVYLSEEEEAEVVTLEVDQLLGSHSGLIAPKDNEYVQWLQTVTNNIARVAVDDIRDPVRKYDNDDPNAKQYDVNIICDSSTLNAMCAGNKILIYDLMIEYLEFNTEMMAVIISHEVAHSIQRHFVETHGFASFMLMIGDISRGVFWMLTESLGPYVNQKLNEMISGFVTMETETTYNRGLEKEADLVGLMLMAKAGYDPRTALTVWSKMSEIDEKTDSEAEASQIAKQKVEAKSEDTMSSIANANLPNKAGQADNLNVSVKEFVDKLLSSWFGSTHPPSVERLEYMREYLPEAVKVYEQTLAVNGQPHAYQFPQQDSSPQEVQPTYSDSLSRWIARIFGSTRDANNGVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAI8</accession>
    <name>A0A8H7UAI8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_004450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAI8"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="244"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="592"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="624"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="646"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2174427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="743" mass="82546" checksum="9D3401B9D7F38047" modified="2022-01-19" version="1">MCSACEEAGRVCKVDQPCKLCLDSSKLCHYSYPDKLRQVWEQSVERYGREQALERLANTVKEDGSAESSQKAKNSRLPFGIHSSLLKTHQIDALGHFIGETSGVMTVAGNANLSANEVVSPQVNLVPPMVSTYNQAHLLDSYFTNVHPRYPLISEKNLKEQLQAQSSGQPSSISIFFLYAIYAGGAKMMPSNVDFSVRVFFDYCMEIKHLFMDRPRISTVCALTLLAACVPDKTTNGQSSKMLSAMLASEANTMARIMGLHRHLSPELESPTMRRDRRRVFWVLFVTDRLYCMMNGFSPSWDEKHIDITPPSPEDYQDDPDMAVVIQEFTHYIKLCKIVGRICNHGYAPKSEEMRTSWKQDTMLSTLDSWLTSYILELPPHLRYDPSTLVATPRMELDFTLTLQHPPKSLFARLMHLIIHTCLILLHSPYISDSEKSDSKTHPVASQPSLDLCIYASTLITHITSVMQQEYPIMASECPYTSHALLIAIRIHLMCALSSDTKLRSSGQSNFIQSANILFRIGQEADKPWIIDTLRALHRIYASSQYSAEASEGISQAIPSDAKRKVLEASPRKLSRKKSMKLSHGSSCAFVTNNSAHSSPSKQVRDPTISPSGVANVHISTATIRSPSSGSSASSSPSHVIGSLDGTLTTSSAESIKSDPSLHENPMFETHFGFPMANAAESAVVSNELLNFNNLEHFPSFGNDPSILYTNPMFSYSTAMQGVSTFNPGWNPPHTPFDPNYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAS5</accession>
    <name>A0A8H7UAS5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_000174</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAS5"/>
    <dbReference type="OrthoDB" id="541719at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000048">
        <property type="entry name" value="Cell cycle control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000306">
        <property type="entry name" value="Cell cycle control protein cwf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000269">
        <property type="entry name" value="Crooked neck pre-mRNA-splicing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="10">
        <location>
            <begin position="68"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="10">
        <location>
            <begin position="316"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="682"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2172824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="704" mass="84338" checksum="B9C92660BAD46D87" modified="2022-01-19" version="1">MASLPPPNAKNPRPPKVKNKNAAPIQITAEQILREAHDRRLEPAHSVPKQKIGDLEELSELRQRKRKEFEDQIRKNRLNMSSWLKYATWEESQLEFDRSRSVFERALDVDSRNVAVWLRYTEMEMKNRNINYARNLFDRAVTMLPRVDQFWYKYTYMEEMLGDVPKARGVFERWMQWEPEENAWNAYIKMEKRYKEVERARAIYARFVSIHPEPKNWLKWARFEEEQNDLEKARDIYQQAVEFLGEDHIDQKVLVAFAKFEIKLKEFDRARVIFKFGLDRLPKSKSESLYNQYTLFEKQYGTREGIENVVIGKRRVRYEEEIEANSKNYDVWFDYARLEEDNGDADRVRDVYERAIAQVPPAEEKRYWRRYIYLWINYALFEELETQDYDRTRQIYSECIKLIPHKKFTFAKIWLMYAQFELRRLDVSSARKILGRAIGMCPKDRLFKGYIELEMQLREFDRCRTLYTKFLEYNAANCSAWIKFAEIERLLGEMERCRAIFELAVNQPVLDMPEVLWKAYIDFEFNEEEYDNTRQLYLRLLERTSHVKVYVSFAQFELSIPDQDTQENTTRARQVFEDAYKTMKEKELKEERVVLLESWKDFEENHGTKETLETVMAKMPKTVKRSKKRKTEDTEGEDSVVYEEYYDYIFPDDETQKPNLKLLQMANAWKLKQAQMSGGAAAAAVDAEPADTMLADAEPEADED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAX0</accession>
    <name>A0A8H7UAX0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="5">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_005894</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAX0"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000004">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="8">
        <location>
            <begin position="38"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="96"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="544"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2174832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="663" mass="73149" checksum="238341E4276B221E" modified="2022-01-19" version="1">MTVEAGSNTMNDPIFPVPKRLLDSKSSPTPYVDSFEKYQEMWKQSVEDPDTFFTNLSKELLSWSKPFQTVRSGGFAEGDVAWFLEGELNASYNCVDRHALATPDKVAIIHEGDEPDSVRKITYRELLQEVSRLANVLKSLGVRKGDNIAIYMPMIPEAVVSLLACARIGAVHSVVFAGFSSDSLRDRIVDASAKVVLTADEGKRGGKSIATKRIVDQAVANSPSVSNVLVFRRTGAEVPWTEGRDLWWHEEMAKARPYCAPEPMNAEDPLFLLYTSGSTGTPKGVMHTTGGYLLGAGATVKYIFDYHPQDIFACMADIGWITGHTYIVYGPLVLGATTLLFESTPTYPTPSRFWEVVQKHKVTQFYTAPTAIRALRRLGDKWLEGYDLSSLRVIGSVGEPINPEAWEWYNEQVGKKNCAVVDTYWQTETGSIIVTPLPGAIATKPGSATFPFFGIKPVILDPTSGKELEGNDVTGVLAVGQPWPSMARTVYNNHHRYLDTYLRPYNGYYFTGDGASRDKDGYIWIRGRVDDVINVSGHRLSTAEIESALILHHSVAEAAVIGGHDDLTGQCIHAFTTLKPNIEDSEGLEKELALQVRKVIGPFATPKAIYCVSDLPKTRSGKIMRRILRKIVNNEADQLGDTSTLADPSVVEMLIDKVKQSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UB15</accession>
    <name>A0A8H7UB15_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor CWC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_005519</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the CWC24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UB15"/>
    <dbReference type="OrthoDB" id="25761at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16539">
        <property type="entry name" value="RING-HC_RNF113A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000045">
        <property type="entry name" value="RING finger protein 113A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5 7 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="237"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="12">
        <location>
            <begin position="251"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="59"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2176285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="324" mass="36090" checksum="EDEABE5A4809105F" modified="2022-01-19" version="1">MEAAEIQQPTNITEQITSSEEKVPFFKKRLASKNLRKRKKSASPERSIAADADDLVSEVVTKDRKVASNPLVQGTKRERNDEEDSTAVGVQYAASKTANTDKMSDATRYDTEWLLQTEEQERSKKSKANKEDDKVDKKPINSKMQRGPIRAPANLRVTARFDYQPDVCKDYKETGFCGYGDSCIFMHDRGDYKSGWQLEKEWEEAQKKKTQFGGGAGDQYAIDSDEDDTDEELPFACLICREEFKNPIVTKCGHYFCEKCAIKNFAKSPKCFACGASTGGIFNTAKNLIAKIEEKKAAQNNEEGGGGDVEIQIGGSDSDSDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UB17</accession>
    <name>A0A8H7UB17_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UB17"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034932120" evidence="1">
        <location>
            <begin position="24"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2178971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="239" mass="25183" checksum="79BE18B7847B89E5" modified="2022-01-19" version="1">MKDGMKFITLATAATLLATVAHGLESVSLPASKVKYGGESYFLVQHTKELKAIGNSTNYKSNGNATELAIGDYCDKVVGCLGHAAATAAAFTYAAGVFTANYCTQLGATVTTMLKDDNYKLTKQIASGIATQFVIPVFAVGATTYYINAKQAMQTKGSPDQCSLGDIPDIAAQGVDAVYNFCLQLKQVTFETAGSRIDFATVSDDSTNDDVGVSLLSQNYISTVKNKLAPECSLLGVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBK5</accession>
    <name>A0A8H7UBK5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_005007</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBK5"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2173589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="256" mass="29052" checksum="929A3E356DB9DF7D" modified="2022-01-19" version="1">MADKCPVDHTQYQKTTTTTNQESKCPVDHKSVDHSAAGEDAKCPVDPSAYKHFLPQPTNAAEGCQSDVINAANNMPTLSQQPAQGQKMKLGVDREVSTIPKSGDPNEKIWVYPSEQMFFNAMRRKNWDPKEKDMTVVVPIHNAVNEQAWQKILEWEKLHETSCGQPKLVKFQGKPKDITPKARIRSWFGYKLPFDRHDWVVDRCGEQVTYVIDFYSGKPNPMVPGSVSFFLDVRPAVSPSGIWDRIRMSFDKGAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBV3</accession>
    <name>A0A8H7UBV3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_004224</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units, alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G protein gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBV3"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000003">
        <property type="entry name" value="G-protein complex gamma subunit Ste18/GpgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041848">
        <property type="entry name" value="Ste18_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00224">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50058">
        <property type="entry name" value="G_PROTEIN_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="11">
        <location>
            <begin position="11"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2174203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="86" mass="9769" checksum="3674493D65F86C03" modified="2022-01-19" version="1">MSGYPRAQNRRTQNLSENKLKRINDYNTRLKEQLDIPRVKVSQASEDLISYCQNNRDPLVPSVWGPIDKREDPFAPASSGGCCTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBW6</accession>
    <name>A0A8H7UBW6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glucuronate decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">INT43_003672</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>UDP-alpha-D-glucuronate + H(+) = UDP-alpha-D-xylose + CO2</text>
            <dbReference type="Rhea" id="RHEA:23916"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="EC" id="4.1.1.35"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="6"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBW6"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05230">
        <property type="entry name" value="UGD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000150">
        <property type="entry name" value="UDP-glucuronic acid decarboxylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078:SF6">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BZIP" evidence="19">
        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="435"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="602"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="816"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="615"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG2179886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="840" mass="94656" checksum="99314326CA835148" modified="2022-01-19" version="1">MVDSEQIGNNAENTAGQADMLNKLKQSLKSGNALNVSAKEGEASNGGNAIGGQGGNNGKKRVTNVGHKVVGSDVELDTLRQLYLPKDPTDRIVHDDGTVSFIHAKSFLPVRMLRASERQRILVTGGAGFVGSHLVDRLMLMGHEVIVMDNFFTGTKTNVQHWIGHPHFDLVRHDVVDPFMIEVNQIYHLACPASPPHYQYNPTKTVKTSVMGTINMLGLAKRTKARFLLTSTSEVYGDPEEHPQKETYWGHVNPIGPRACYDEGKRIAETLTYSYMRQNDVDVRVARIFNTFGPRMSPADGRVVSNFIIQALKGEQLTIYGDGQQTRSFQYVHDLVDGLILLMNKNFTEPVNLGNPEEYSITDFAEMIRNRVSPETPIKNLPATMDDPKKRKPDVTRAITYLGWRPAFSVQQGLEETIECMDPMQLLMHQNTMYDDDFDQDDQDFNSPKRPGRKPMPTSAAARKAQNREAQRAFRERKERHLKDMEETVKKLRTDRRATLRQRDAYKSRAEQLRIQNWYLKGLILTLQLVCMQHKVVIPPHSPFLNEDALCEIAKVVAPEVIESYVKAASPSGITKGDVELPVKPEPTTSNDAIYIDEDMAPDSPYSPAPRMEPNWQTQQHKGTNVKQEDNNISTTDFNNSASEQQPPRQVNLAAIQHIKLKIAMDEFFTSTQSPTTGMQPTILQLAVTHDPRIDLVPTAYMRDRMILFQDLYDIDELVETLVQGAAFMGGDPTDKMCWLVPRELVTKYWYLASASHDLNVIGSPKAQARLAAIRNNESNMVAHMSVPISPRADMGHQNSNRREYFESIPPINSLSPMDSMSPSNQSFYPQQNNYPLPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UC46</accession>
    <name>A0A8H7UC46_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DUS-like FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_005355</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UC46"/>
    <dbReference type="OrthoDB" id="10262250at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004653">
        <property type="entry name" value="DusA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008774">
        <property type="entry name" value="PRK11815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42907">
        <property type="entry name" value="FMN-LINKED OXIDOREDUCTASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42907:SF1">
        <property type="entry name" value="FMN-LINKED OXIDOREDUCTASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="12">
        <location>
            <begin position="32"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2176122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="388" mass="43675" checksum="FD122832C571FC19" modified="2022-01-19" version="1" fragment="single">YQAVVARHSTSVTMTVNGSTRAIGRLFRAVSIAPMIDVTNPHFLQMLRIISPRYTLYTEMIHANAIINNRHDISRFVGDANPDTVVQLGGCEPQAMATAAKIVQDHGFREVNINVGCPSDRVQHGNFGAVLMKSPHVVANILNEMNKKSVNIPVTIKCRTGVDKFDSLEFLQDFIDAQLCSERPPPHFIIHARKCFLQGLSPKQNRNIPPLDYNRVWKTAQKYPDTIFSINGGFKTVETIADALTKVDGCMIGREVMDNPMFLQQLDRGLFSYCARFSLGKTFEDATVIVVHFQQLTFFSAYVDDFLTSKPAGSHLPSMAIMMKPLMMLYRSGYGRRFRRALGEGMTEARKSYPHKCHWDLAPVVYKALEQAKIVDIENDQHCKQASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UD43</accession>
    <name>A0A8H7UD43_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UD43"/>
    <dbReference type="OrthoDB" id="10374672at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2181206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="109" mass="11612" checksum="01EDD7DAE8F1CFB9" modified="2022-01-19" version="1">MSDKIPATEVIEQLGRGGDSNMTSGSTGFGANNQRRRSSGFSGSGIMEGSGDSGIFYGGGNQRNGSLGGGGSTFKSLETHRRQSMDKANEFQQQYAKDGVADRFKSWFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UED8</accession>
    <name>A0A8H7UED8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_003671</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UED8"/>
    <dbReference type="OrthoDB" id="2148442at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="29"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2179885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="374" mass="40785" checksum="BF0F6C3CE71762BF" modified="2022-01-19" version="1">MANDNLSAVIYGPKDLRMENREIAIPKAGDTDSFATEVQINVRATGICGSDIHYYHAGRIGNRVLDPKNPMVLGHESSGIVSALGEGVKNLRVGDRVAIEPGTYCKKCDRCVEGRYNLCYEMHFSGSLMNGPNHGSLCRYANFPEHLCHSIPETMTYQDGALIEPLAVAVHSVNKTPIKQGSHALVFGAGPIGLLVAATAYAKGAEHVTIFDINEHRLQFATEYLPKIKTVQLPLPESDTPDLLAWSQQTIEKLVTSGVIDRENIDVCFECTGVESCIQMAMFAARRGGVIMLIGLGKGRALLPTEVMSVREVDVRGNFRYAHAYPEAIELVSQGKVPLRGLVTHQYKLEDTLEAFDKVMKGGAGVVKVQIGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFF8</accession>
    <name>A0A8H7UFF8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_006797</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFF8"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF15">
        <property type="entry name" value="TRANSCRIPTION FACTOR MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="292"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="411"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="113"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="591"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="521"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2183786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="692" mass="78521" checksum="38AEBC95AF89FF72" modified="2022-01-19" version="1">MSTSQAPQIFKATYSGVPVYEMQCKNVAVMRRKADSYLNATQILKVAEFDKPQRTRILEREVQKGQHEKIQGGYGKYQGKYGTWVPLERGVSLARQYKVEHLLQPILDYIAGDTSPPPAPKHVTAAHSKPRKPREPRKRRKKVPAVEALVSDVEDSSQYSDGAESDGSRHVAMDTVGTRTPSPLARQAISDDEHGYHRRQSISRNRNSQLLSPSYQRRANRTPQHRQPVKRRKLMETEYSDPEDMEEDDGDEKPSFYAQQLLDYFVSDSADVPEILMNPPDDFDIDVIVDEEGHTSLHWSAAMARIRVVNLLINQGADIFRVNYRGQTALMRAVLFTNNFDTKTFGTLLDLLQKTIFNIDKNDQTVFHHIASTAGWRGKVHASRYYMECLIAKLSSNRRELIAVLDVQDVYGDTALTIAARIANKKLVKLLLDAGASPDIVNEEGKTAQDYITDADQRYRFDGDNGNRLLGSATSDMEQGTTRNLKRNVAAVLGQAINQTKVVPTVTKLFDELSTSYEKDILDKEQDIREAKLMQRSLKRELIEVRSKLHNISSKADLLKDAESKVEQLQSELFDLIELNQKHKLLGLLDQEDLKPPSPPQSDVQEDSTMADQESLEKEVETMEQEWAELQTKRQRLVKDISHHRAQPANERHQDYKRLIALCCGVEYDSVDVLLNPLLEALDAEDSPRSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFH2</accession>
    <name>A0A8H7UFH2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_008667</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFH2"/>
    <dbReference type="OrthoDB" id="6080404at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03399">
        <property type="entry name" value="SPFH_flotillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806:SF31">
        <property type="entry name" value="FLOTILLIN-LIKE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="FLOTILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="6">
        <location>
            <begin position="4"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2181085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="456" mass="51306" checksum="D6BEAD750530BD7E" modified="2022-01-19" version="1">MFKVANANQYVVKTGFGVSDIKVCKKTVVWPGQTAQYFDVTPHNFELSLHAMSVEKLEFLLPAVMTIGPRIDDASLAKYARLMTGKSQSNVPELVKGVIEGETRVIAAGMSMEEIFKDRKAFKENIIRNVQSELDHFGLYCYNTNIKSLQDTPGSEYFSYIRMKTQEGAVNQAKIDVAEARYKGDVGEKERTGMTRQQVGRIEAETVVYENERKAEMFQAQATLETRQAEYDRQVQTAQIEAKQAANMRQIELQRQYEEKRQLAETERLRADVVAKWKAEYEVSVEKANSELYNEQRKADAALFKKKQEAEGMYYTTSKAAEAQMKKADAYLYEKKKEAEAIDSVMLAQANGLKNLVSAFNGDTNAALSYLMLERGTYQALAKENANAIKGLNPKITVWNQDGKTQSNPIADIYKSLPPLIETMRDQTGVMPPTWLANVAPEQQAAQTKSVVNGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFJ6</accession>
    <name>A0A8H7UFJ6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_008742</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFJ6"/>
    <dbReference type="OrthoDB" id="660550at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF1">
        <property type="entry name" value="ASPARTYL PROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase A1" evidence="9">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="88"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2181160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="171" mass="19155" checksum="E3AA893809A65C4F" modified="2022-01-19" version="1">MSKVDTERIDPNINYAKVTDSSPYKDYWAINIDGVSIDNQVHPESRSIVALVDTGTTMLLAPEAITRDLFRRIPDAYHDYTGLYSVPCNSANRIPNFTVIVNGEKYVLDGSKYVIPAFQLKNSRPGYCYTYIQTGSANLPMILGYGFLQTVGTVYNAETRQVGFGRHITKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UG02</accession>
    <name>A0A8H7UG02_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UG02"/>
    <dbReference type="OrthoDB" id="200660at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF0">
        <property type="entry name" value="PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2184371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="129" mass="14803" checksum="86301DD39098E8C0" modified="2022-01-19" version="1" fragment="single">PLQIELQECEQNTVVLDSLNNVAKQLVNNEFLKHRDKRVRAIVSCCLADILKLYAVDQPPYSDNELKAIFSLFISQLKELSNISDPYYDNRFYLLESLSMVQSILIIKQLNNSAAMMTELFKTIFGLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UG87</accession>
    <name>A0A8H7UG87_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UG87"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="249"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="477" mass="54269" checksum="8638B7E39AD1DBAC" modified="2022-01-19" version="1">MTDITTSLDATTKTSPPAPPAAHRRRQSWLRGNSFLSLLPELSSYKKRRSQSLGNVRLSEEPHDDTRYSVDTTYYQEPDSPEFDQRRRRSSDRSTSTKSSISSLFAKVARKRNFIKRENSLNLQSAPSSMTTADCKPYVPFVSAFDDPLLGHRNQSKRHSTSSSSTAIGPEYANGKVSPPASSPRLAYIEALQPDKKLDLDEIRNDAYPIENDEVEVDRLQAKNDLVKLAFDGDYCAPLDFTSIEYPRILDIGCGAGSWCIDLARRYPDATVFGLDCQDIFPDPKNIPSNCHLLVHNVLHGLKQYPDGWFDYVHCRFMMLAFSPEQYIQVMTECIRVTRKHGFVEVMEMDLRIYGDPTAGPLTQQLNEEVIYAAESLHLSPRVARNLDGLFPNTSNISSANTRYLSMPIGMWGGRLGVLFKDDLFMFTKKCQTAVAQARNRPARSDEEFMREMERVSREVEAYRCFMNFHAYWVEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGF7</accession>
    <name>A0A8H7UGF7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione gamma-glutamylcysteinyltransferase</fullName>
            <ecNumber evidence="1">2.3.2.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_001822</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.15" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGF7"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016756">
        <property type="term" value="F:glutathione gamma-glutamylcysteinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046938">
        <property type="term" value="P:phytochelatin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.30:FF:000001">
        <property type="entry name" value="Glutathione gamma-glutamylcysteinyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.30">
        <property type="entry name" value="Phytochelatin synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040409">
        <property type="entry name" value="PCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007719">
        <property type="entry name" value="PCS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038156">
        <property type="entry name" value="PCS_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33447">
        <property type="entry name" value="GLUTATHIONE GAMMA-GLUTAMYLCYSTEINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05023">
        <property type="entry name" value="Phytochelatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51443">
        <property type="entry name" value="PCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0104">Cadmium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase C83" evidence="5">
        <location>
            <begin position="69"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2178973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="502" mass="56426" checksum="2D5E7F5D4F225BD0" modified="2022-01-19" version="1">MLRSLTQSYPRRSLSNVVRLGISQRSAQSRLCIIAIHKKYSTSTTVKQPAAEANESPFKAYMPRTENPELQNTFYQRKLPEELVKVSSPEGKLLFREAMDAGQTEGFFPLTGAFASQSSPSYCGPSSLALVLNALNVDPKKIWKGAWRWYSDDMLHCCSPKEQMQKNGITFDQFACLAKCHCNVVVKRATNITFDEFLKDLEKTTASSDQHMVISFSRKTLGQTGDGHFSPIGAFHPKTNKALVLDTARFKYPSYWCSAKVLYDSLMPIDKETGRSRGYFLLSYDDLNPPISLCHTKSQQAIQPVPSTPNVTEDAQEVSKDTTIESNLPASACKSTTKFSANTSLNWSALAKVFCQKIPEDMWLEKPQTLQQVVHLVLRNVPREFRYILGQRVTSPSTATANSYIDALFQDTVTSPLYPVVYESLYPSQSSKIPDTHAVFATLFLLGSPRMLYTSLPRDLQKAFDRYRSNLESMPLVRREVDRISVEISELTKSFCTCGKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGJ2</accession>
    <name>A0A8H7UGJ2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_001928</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NSE4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGJ2"/>
    <dbReference type="OrthoDB" id="361242at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029225">
        <property type="entry name" value="Nse4_Nse3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15412">
        <property type="entry name" value="Nse4-Nse3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nse4/EID protein Nse3/MAGE-binding" evidence="10">
        <location>
            <begin position="117"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Non-structural maintenance of chromosome element 4 C-terminal" evidence="9">
        <location>
            <begin position="253"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2179078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="353" mass="40045" checksum="43DAF160CCED5E13" modified="2022-01-19" version="1">MSEAVHSVLPGNGSPERDYEENVSAEEAEEDEEDEEIDELQALTQRLNKEIDRSQYDPSQDKSERRTIRQRYRELIQSAEEIKRQVAVGEADALKETMQKANELYLQVRNTQEATLDSRLLVLSADLSVQKARKMRVDFNSFDTDEFVSKIISLGGGRHLADSNNDSAELNWQDIGKQAVRFGKRAVTMDFMQGPLAVEKKQRTVSRQARIVKNKEDLVTPQQLREGDIKASENDTANNVNAIYRILHQNGPTNYFKLVTNPSSFSQTVENIFYVAFLIRKAVASIDDSSGIPIISTHEPPTTDELGDGLPKKQIIMSLSMDLWKDIIETFDIQESMIPTRQRTEITGGQWYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UI11</accession>
    <name>A0A8H7UI11_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UI11"/>
    <dbReference type="OrthoDB" id="2329895at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1460.10">
        <property type="entry name" value="Nuclease A inhibitor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012489">
        <property type="entry name" value="NucleaseA_inhib-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036587">
        <property type="entry name" value="NucleaseA_inhib-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07924">
        <property type="entry name" value="NuiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82602">
        <property type="entry name" value="Nuclease A inhibitor (NuiA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="190" mass="21071" checksum="F2904B4AD7D8AD52" modified="2022-01-19" version="1">MALANFIAVPSNQFVYKMSDDAYISMLNNPTINPPGDQTGAGVEPVSQSRFTDPLGATATSIKQRLEQATDDLVYISESDEPFKFFNIPWKESQFPSVEQFISLVKDDELDEQEDDSRSTSSLESFFEPLTNGDDPYNQSGQYVKLQDALVESFGDKVKVYVFGAIEKNIYIAGLCEDGLVGVHTKNVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIT4</accession>
    <name>A0A8H7UIT4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_000598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIT4"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2184685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="77" mass="8783" checksum="452A8549BD88C73E" modified="2022-01-19" version="1">MSLLPTANSLGQSASYPFDDRIRQVRTSSAPFPVILKRIFRVPHMDFEHCHEVCIMADGISFDRSKKSIPKYILSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIU7</accession>
    <name>A0A8H7UIU7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TAP42-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIU7"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="39957" checksum="16A6101FFFAC63E8" modified="2022-01-19" version="1">MENLSLAELFNNGQRIYQDLKESKLGSADPSYQRQVEEGILYLGRASDLVQRLGIFSENEILDDINANDLRFLLVNAYLGSLVLQQTGGNRKDILERAKTYLLEFMHTCDVHQIISQEDLRILKRFQDSDSAPRLDAATSREQKIERYRREKETDLKVKELQNLLEKSGDKAETNVDVEDIERDLIMSLIQYQILKALEHLQSIDQELVMVLEMEKMRERAAHGDDATSDTRSPLTSRMDPRNANGPLLSKTGKPLRPFIITNKRQELRDQVFRPGWALPTMTIDEYLQQEEERGNIIKGGGNEQAQKPEIDDNDYEALDAETMKARDWDVYKEDNPRGWGNRGNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJY1</accession>
    <name>A0A8H7UJY1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_007444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJY1"/>
    <dbReference type="OrthoDB" id="2128908at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2182513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="237" mass="27391" checksum="B5C161DAF4D5FDFD" modified="2022-01-19" version="1">MQRFARALLIASILLNATLILKIVNHYTINMNKVEYIDMRMNVYVETRDCGRNFAKIQTSIPNAIAISDEPCAHKEHVFKSYVEDIGQQDGHLWYAYKYIETLKICMHGNKMLCMILEDDVIFVHKNETMWNNIAVNTVSLVANEDTFWDCSTRELWLSAWHNPARTLCRIYNTERLPAFIRCMEQTLRDGPTLEDAAVGALITTCQTNLKIQQKRFLLVNHSGQKSLLAKNMKLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKD7</accession>
    <name>A0A8H7UKD7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_007036</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKD7"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01089">
        <property type="entry name" value="PA2G4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000029">
        <property type="entry name" value="Proliferation-associated 2G4, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004545">
        <property type="entry name" value="PA2G4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00495">
        <property type="entry name" value="crvDNA_42K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="3">
        <location>
            <begin position="21"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2182109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="383" mass="41368" checksum="ACD31EC47757089B" modified="2022-01-19" version="1">MADAQQKVVDTTIANNDVVTKYKTAAEISTRVLNQVIPLCVAGAKAIDICIEGDKLIREATKAVYNKAKTPKGVGFPTCISINDCVAHFSPIASDPEAATTLKDGDAVKIQLGAQIDGYGAPIAHTVVVGASAEKPVTGPVADALKAAHTALEAAVRMIKPGNKNMDVTKAIGQITDEFGVKCVEGMLTHQQEKDVVDGKKQVITNPSEGHLRDFERVTFAENEVYAVDILVSTGEGKTRQMETRTTVYKKTGTRYQLKMQASRAVLGEINTKFGNFPFSLRDLDDERKGRMGIIECAKHQTVLPYDILYERDGVVVQFLATLLLTKNGNVKITTPPYDPAVVKSDKELKDEELVKLLSTPLKPSAKKNKKKKAAGEAEAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKF5</accession>
    <name>A0A8H7UKF5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_000945</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKF5"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00846">
        <property type="entry name" value="caca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="399"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="124"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="334"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2185032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="500" mass="54556" checksum="2940410CAEEB2FE7" modified="2022-01-19" version="1">MSLKTKPSTSSSFYYEPTQTQSSQEHIMMQDQPTSPDQKLTARNLSWKQNLTTEQDAAGNTSTADQQLNGDGLDNVPEKKKHKWKEPTAKEGLMAIIKSSWLNVLVVFIPIGIASHFTNWPATVPFIINFIAIIPLAKLLGFATEDLSLRVGEVLGGLLNATFGNAVELIVSILALVKNLVPVVQASMLGSIISNLLLVLGMCFFFGGLKYKEQSFNVTAAQTSASLLFIATSSLLLPAAFYGSAYGFSNQSQSKVAADVLNISRATSIILLIIYGAFLFFQLKTHKSFFLEAPKEASFFERSSSRVRSDIEGANLEAEEEEEEEAPLMPLWMAMVLLAIITALVAVCAEFLVDAIQEVCEQWGVSQTFVGLVLLPIVGNAAEHVTAVTVAYKNKMDLALGVAVGSSMQIALLVTPLMVILGWIINIPMSLYFNMFETVVMLIAVLMVNYLIMDGKSNWLEGLMLFLVYIIIAISIYYYPSDGENSLAPTNSTSSNSTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UM75</accession>
    <name>A0A8H7UM75_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Suppressor of G2 allele of SKP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_000826</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SGT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UM75"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000012">
        <property type="entry name" value="SGT1 homolog, MIS12 kinetochore complex assembly cochaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="5">
        <location>
            <begin position="182"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="4">
        <location>
            <begin position="283"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2184913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="42029" checksum="0CA8F2EF7705B384" modified="2022-01-19" version="1">MVLKKHFKFRYPFFSFVPRNAQYLMSASDLFTQANEAFFEDDYDEALQLYSQAIDADSENPEFYLKRGIVYEKLKKYDLALQDANKSLAILEAQQGSRTQLAKAHLRRGIALYHSKQYSEAKKELSASKELNPAEKTLSTWMRRWQFLKSDKVPATAASSTTTGRSASEPAPVSTASATPVTERARHDWFQNDQFVVVEVFIKGVQKDSVDIGFHERSLSVTIKMPSGSDYSLELEPLTHEIDPSQSKFTVLSTKIEIKLKKKSVGTKWGMLEGEDVIPQTISAPWTSNKPKDWSALDKELSSEEPEKPEGEQALNALFQQIYGDADENSRRAMMKSFVESNGTCLSTNWDEVSKGKVETKPPEGMIAKKYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UMU2</accession>
    <name>A0A8H7UMU2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATPase inhibitor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_000508</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inhibits the enzyme activity of ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UMU2"/>
    <dbReference type="OrthoDB" id="5532350at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2184599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="92" mass="10467" checksum="8A23FE040FF08738" modified="2022-01-19" version="1">MFFPLAIRQSLVRQRFPAMVLKRFDHGGPTAGAVASSKGFGTKEKAVENQWARQHDVEKLKALSEQLKKQAEQTKTMQEEIDQLRKRVKDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDA2</accession>
    <name>A0A8H7PDA2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WHI2-like protein P4H10.16c</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDA2"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF16">
        <property type="entry name" value="GROWTH REGULATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="47779" checksum="BB2A54599312F9FA" modified="2022-01-19" version="1">MSLDDVTLFSANDNDANHYDADPSTEGQFAVFGPELRLTEFQLWGMTWRCDLYTLAAPHQCIAGQNGGEHIGREADCVTKNLVSEIYLVRLRIVSPSITPDMTSESPITQVPETTSPHLGHGGDQDQLIYQQQPGNPTDQANNSFPNKLKLDLRGTRLDIDRDTLVSLPESLLIVMFPNGLILGRVHDDEYDDDEDEGSNDSVALEDQVNYVDFDPKCLDFVLQYYRHAQQVFAEEHSGDNNSFQQGASSMPMMNPNQHPLLTKQAIIVLREELEYFALPPSAKEKGTSPATNESMRKLKLDCGKYLLERDQIFTALQRNISKENNVAEQHLIDMLCDSGFSREDKWGYRAMEPLKTCIVSIALVMLKTTGPENHMATAQKLLLFWRKPARKCWWDGNAVEINNESIRLWARRTWTLELALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDA9</accession>
    <name>A0A8H7PDA9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein L37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_008203</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDA9"/>
    <dbReference type="OrthoDB" id="10259236at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000001">
        <property type="entry name" value="Ribosomal protein L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_eL37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_eL37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2171823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="95" mass="10660" checksum="E2FA6B1BD4CDA0EC" modified="2022-01-19" version="1">MATKGTTSFGKRHTKSHTLCRRCGNRAFHNQKKTCASCGYPAAKIRSFNWSVKAKRRKTTGTGRMRHLKDVSRRFKNGFREGSQAKKQTAPATSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDR6</accession>
    <name>A0A8H7PDR6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small RNA 2'-O-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.386</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_001527</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>small RNA 3'-end nucleotide + S-adenosyl-L-methionine = small RNA 3'-end 2'-O-methylnucleotide + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37887"/>
            <dbReference type="Rhea" id="RHEA-COMP:10415"/>
            <dbReference type="Rhea" id="RHEA-COMP:10416"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:74898"/>
            <dbReference type="EC" id="2.1.1.386"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. HEN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.386" evidence="11"/>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDR6"/>
    <dbReference type="OrthoDB" id="2154311at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090486">
        <property type="term" value="F:small RNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026610">
        <property type="entry name" value="Hen1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404">
        <property type="entry name" value="HEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404:SF3">
        <property type="entry name" value="SMALL RNA 2'-O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2172050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="359" mass="40820" checksum="5565870D3341EF98" modified="2022-01-19" version="1">MVTNDAGGQAFNPSLWRQRRAFVLEILRDHAVTSVMDYGCGEGALLSVLTQASCVDGITQLIGLDLSNTALGLCAKACEPWQVDYDNLRESPLEINLYQGDATVPDKRLAGSDAIVCCEVIEHLQPHQVRVMLPILLSDYQPQLLVVTTPNIEYNINFPELRYDTPEQQLRNDDHKFEWTRHEFETWCRNGAQTYGYTAEFYGIGKLNHPVVDIDVGYCTQACVFTRSSIAQPRTNLSQTPHVSFKHIIFPWYNFPDKPEDEAIEELSDIISTMTLVTTSPEALSSATLNWCETWSWDQVMDSPPSPTVLSNEESHATIVHCDVSFEDVWNVLRVRQLCRTRERLRDFLEKLPQAHIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDT8</accession>
    <name>A0A8H7PDT8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDT8"/>
    <dbReference type="OrthoDB" id="8026949at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="580" mass="65532" checksum="EE12F53BC636D360" modified="2022-01-19" version="1">MDPSARRYQLSAHHNPSLYEIIDSPRELNDWNPYDVPWDTKRRLRVSCTSTKDSLTKYTSSDIDHQCNINEDEWYCDSGSSSSSTSSNDRITPRRSGDSLTEERSRPPGAAWRARISQGGEDTVQKKNKKPSSGKKVSLPKDSTLTRNKHQIQNLSTKDGEEKTVKTDEIALFMRCKKRPSDIEVLPIPPSPGGWDDVIPDRTMRWGEVKAHSGAEKVHGQQSSWSSGNDTKLPRDEKNKRTLRHDPPTQHSNRPKSSTRTNSKITDSDRHDMLHMKNASSQNASSSWREKHAAARPQAILKNDMSSSFYNVPMPMPMDTRYKHSGQFYAPPTHPAYADMSAAKAYPTSDMLPSKSNPIASQRQWRSEQEACHAHFANETPQMMSNEQTWHPDSFSSHWDPQPRIFHNSEPQNPVGWKERKYSLDSVCPPHTYDMNTPMSSIDLQSRPNWPSIPSIWGIGPQETSPLRPRRASADVGTFSTAPRMGAADWQTSNGLEDWSSMNKNVGSLMRLLEEDVTPTPARIPHEKIIHDISCHAPAEHHHNRLFDNDTSSLPQPSCNHCGAVSNHKALSSLQDPSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDU2</accession>
    <name>A0A8H7PDU2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDU2"/>
    <dbReference type="OrthoDB" id="2373721at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="154" mass="18149" checksum="26489E13D7C51BFD" modified="2022-01-19" version="1">MSITVLPSNQNNSRKLTNAFAKLNIRRSSQVEQNSKSISPTTPPPARTAVVTSDPCSIRPERRVSFTEEPPKVHYFDRQDHEEDWFIYDAKLDDERNCPWKYYCREEKKGFKGTLKSMFSGQNKKCINENDEEDWEEYQPTNLWRQDTAAIFMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PE86</accession>
    <name>A0A8H7PE86_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinylglutamate desuccinylase/Aspartoacylase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_008116</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PE86"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06251">
        <property type="entry name" value="M14_ASTE_ASPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055438">
        <property type="entry name" value="AstE_AspA_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053138">
        <property type="entry name" value="N-alpha-Ac-DABA_deacetylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010282">
        <property type="entry name" value="Uncharacterised_HutD/Ves"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37326">
        <property type="entry name" value="BLL3975 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37326:SF1">
        <property type="entry name" value="BLL3975 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24827">
        <property type="entry name" value="AstE_AspA_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05962">
        <property type="entry name" value="HutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Succinylglutamate desuccinylase/Aspartoacylase catalytic" evidence="6">
        <location>
            <begin position="453"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="280"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2171736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="743" mass="81425" checksum="7163310DB82D0ABA" modified="2022-01-19" version="1">MDSKNNDLPSGSIVESDSPEPSLLEVACLTPEKDYREQTWKNGLGQTSEIAIYPKQKNFIKDTFFWRFSISTIQANCNFSLFPGYECTTIVLPSGNDHKSTLLLNHKGEEVATNIKQLFPYTWSGEWTTSCKVTNPPVHNLQFVINKDLGKAQFNVEKIGQPVSTENGETGRKMILGSFVLVYVVEGHVRIGVDENHAQGHTRVLSAGHTLYIERDEEASPTNLMMQASDEKGAVGNHDLDATVAVITITENKHQGAPSTVSDYIAAGSKSAATVDPLTITGTAPQTTFPPQSPPGDIPSQRRAAPRRKGSLVVYDDQPLWNLPPDLAQKLASKEAVASSNAFPVSSELGGELASLRQSVGGLNMEQPAVEARKESIGGTTPATKWESAQTYEPPSFETQQDTEVPPPVVRDRLVVEDFPVGTISTAWIKMVRQGLSEWLRLPVIVCRGTEEGPVVGITAAVHGNELNGVPCIHRVVSDIDVHKLTGTVVAVPCVNVTGYLKFTREFADGKDLNRYFPGKEDGFAAQVYTYQLMQKIISQFNYLIDLHTASFGRVNSYYVRSDMNDPIGAVMAHLQQPQVILHNSGQDGTLRSAASARGIKAITVEIGNPQLFQNQYVQWSYMGVMRILDHLEMFKMDNADNDELYPPPPTTVLCSKGFWIYTKTGGVLEVYPGVNTTIKKGDLIARIKNIFGNVVDEYFAPCAGITIGRSSNPVAMAGDRIIHLGVIKKKGEVLPKDAKENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEA4</accession>
    <name>A0A8H7PEA4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCDC174 alpha/beta GRSR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_001546</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEA4"/>
    <dbReference type="OrthoDB" id="333551at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025066">
        <property type="entry name" value="CCDC174-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057464">
        <property type="entry name" value="CCDC174_GRSR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25449">
        <property type="entry name" value="CCDC174_GRSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13300">
        <property type="entry name" value="DUF4078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC174 alpha/beta GRSR" evidence="3">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2172069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="305" mass="34726" checksum="6FE5C6095366F8EF" modified="2022-01-19" version="1">MPKSIDVSQATALDLRAQLASQRESFDLDRRKGKQVAASERRHNKKPTVWARQNKGVSERAGKDKVELEAVAGPTLEASRAALQRKAKLYDQMRKRRRYNDDDNDENNLIDFDRQPLSSDEEDEGDDDDRSDTNDPWVDYVDEYGRTRTVRQSQVPKPRSPSPDYTPQAAYPVFTQGEETSSSSSSRRREEADEEVKRYDANQEIRAKGVGFYAFSKDEDERKAQMEELKQLRQQTEKARTHTVSVAAKRKQTLENNAAKINARRLLLKQKAAGSKAQAASPSSKQPDINEDSVSSFLRAMRNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEH2</accession>
    <name>A0A8H7PEH2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEH2"/>
    <dbReference type="OrthoDB" id="5572730at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2172442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="155" mass="17581" checksum="1183817E9393E9AB" modified="2022-01-19" version="1">MELSDIQRERLHRAANIAANASWEGDISGLAFAMLRYAGLDIENGYLITSENHVSNGKPDIMVEVLVGRRKILIIECKKDTSHPTRSKQQLEGYMQDGVFPHGILMYPRNSIFFSLDIEEDDAEVQVGLTYNNVTDFEEMINAMAQMRIPELEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEW8</accession>
    <name>A0A8H7PEW8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEW8"/>
    <dbReference type="OrthoDB" id="3044029at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034542963" evidence="1">
        <location>
            <begin position="19"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="168" mass="17740" checksum="2BDD030886665BED" modified="2022-01-19" version="1">MLSKLLLSVLALAVAVSSLPIAKRGSGVAIEVKSSSQFCFYLPPHKGGDIAASEDNAIPACTDTSLASGAIQFPTGFIKSAHYVSTSGYVQVTGRIDRTQYGLKASDGGGQMDNLDLPKGTCNGYKHFVNLVEPDADVYCIRCCKDSSDCNLGKSQYGCERVVPGDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PF83</accession>
    <name>A0A8H7PF83_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_004757</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PF83"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="10"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="316"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2172216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="464" mass="50230" checksum="A2E5FBED98E6CAEC" modified="2022-01-19" version="1">MPDPTKEQIQEIFKKLKANRYNKVCFDCNAKNPTWSSVSFGIYLCLDCSSSHRNMGVHVSFVRSTVLDSWSWDQLRTMKVGGNQAAREYFSAHAGSSTNKDARTKYSSAAGSKYKEILLQRVKDDAIKNPSLVDIEVEDKTSMSSAPLSPAVSTPSAVATPSNASTPSDIQNESDDFFTNFEKPKPAPRTASSRTASSMRTKTNLSSSSRTRVGTKPMKLGAKKGAASFNFEEAEAKAKEESERAAKLGYDRAAETAEEEAAAEEANSSTPFSSRLAYNDGTTSTSTSSKATDQDGAEKLGFGMSRLGFGAVPQAGATQTKTNVPSRMTGFGSSPSSSANDDLETTSARDKFSNAKAISSDQFFGRGNYDESASAEARTRLAQFKGANAISSSQYFGRDEDESMPRRSSASGYEWDDIQDQATDMARKFVDQASADLGAVRDIVEQSTSKLSDMLADLQSRYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFX5</accession>
    <name>A0A8H7PFX5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CigA protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_004596</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFX5"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36050">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36050:SF1">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034017612" description="CigA protein" evidence="4">
        <location>
            <begin position="32"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2173222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="62885" checksum="0AB2A6BC01C1600E" modified="2022-01-19" version="1">MIPRRRLAVLIGCILVFVFFLTINPSDPAMSQPDSDSPPVYDKKVDVVQPPENEHVTEPESVPSTPKVTKPEAVHIISKPDIDAPVDVHPDEKFITYLPHSGFHNQRIEFENAMLLANYLNRTLLLPPVFLWSLAMPWLRYEKCYERLLLQSKYGLDHCKDIPSGYPVPSECLNYDTWTSVPWSFFYDMEGFKKNARFIQRYDLSYQWLYKNLNMKAKDIHFEKDLTPFDFRVFDDPDSNTPIGRFKNRIDLATLEAIPQKVLHFGSVFGTYRILAQTPEHAEVHRSIRNNLIFRNEYLMRATENIVRKIGGVKGFAGLHVRIGDGLFARRKTITIDDMYHQLVNQFTDLTQEEVEKIDFTHLDDRLEDEDYEVKRLRWQDNATEIVPEPLIVQHPPQEELQKTLQDITPISMACANHNGKTATFRTPIFLATDAPKPRENPLFRKIFDTFPCVFVLDDFWDDLNELMQLQVVEDGVNLSSYLIPMVDAMISAHGHTFMGTKDSTFSSYIERYLHPVYIGDEVKLMNTGRKGLKPGDDTPAVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PG21</accession>
    <name>A0A8H7PG21_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_004683</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PG21"/>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="469"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2173309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="57928" checksum="D35EB0D5C1DF76DA" modified="2022-01-19" version="1">MRPNFDTHQPASRTRPQSLTRSYSIHGTPAAGHSNDIQVTPPSPTLSSCTVAVDTAYELKTYPQAWIALFLLVCLRAGSAVFQYTFAPIPAVTAEYFGVSLSAINWLSNIQGLIYVFLSFFTGWIFEKLGVKKSLILAGFILSLGCWIRWFAVLIHPPSFAITMIGQVIAASAAPLALNIMSMFQSLWFTDNLRATAGMFVASNYGAILGMFMIPAVATGKDNIPLTLIIVAGIATAGFVPLIFMPAKPKTPPTYAQATDRPPFFEGLKMLSKNGHYWILFLIHGINVGLSMALATIFNQVITPYGYTNAQSGQLSAVSFFAGTLGCSVAGPVLDMTKQHKLFLRLMAPLTLATYIGFIFIIKKDSFAAIMFTSIMNQFFLSFLVPVVVELGVEVSYPVAESTSNSMLWQGCQLFGFIFVLIMDQMRDPNGDPKDNMRKALILQAALMGLCTIFAFVYNGRNRRTEAMEEERLQREEDEKAMSILEPPRWDRERSGSVCSEQSDATRVEIRDLEKQKGKTVEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PG91</accession>
    <name>A0A8H7PG91_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Needs CLA4 to survive protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">UBA4</name>
        <name evidence="15" type="ORF">INT43_004682</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PG91"/>
    <dbReference type="OrthoDB" id="10261062at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070566">
        <property type="term" value="F:adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042292">
        <property type="term" value="F:URM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000014">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000033">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03049">
        <property type="entry name" value="MOCS3_Uba4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028885">
        <property type="entry name" value="MOCS3/Uba4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004281">
        <property type="entry name" value="PRK05690.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rhodanese" evidence="14">
        <location>
            <begin position="351"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate; for adenylyltransferase activity" evidence="12">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate; for sulfurtransferase activity" evidence="12">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="118"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2173308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="448" mass="49502" checksum="75C6765A836D8E3A" modified="2022-01-19" version="1">MREGRAQFKVNMSLQEENERLKRRIEELERQNNIFEQSRSPEVVWPLPAVEQLSNAEIKRFGRQLILPDVGITGQKKLRNTSMLVVGAGGLGSPICLYLGGAGVGRIGIVDHDEVDISNLHRQVIHTENGVGVNKAHSAAESIRSINSHCEVIAYDKVLDSSNAMDIIPNYDIVLDATDNVATRYLLNDACVLAGKPLVSGSALRMEGQLTTYNYNGGPCYRCLYPTPPPPETVTNCADGGVLGAIPGVIGCLQALQAIKICIGLADTSFLARDPPTLLIFSGASSTLFRTIKLRKRKEDCAVCGENPSITELIDYVQFCGRGATDKDEPLKVLEEQDRIMVEAYQQCLTDKTPHMLLDVREPVQYEICQLPGSYHIPLKQLKKRIDDVKQELESRNLAGSDVYVICRLGNDSQLAVRILEENGISAKDIVGGLYEWANRVDKEFPMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PH22</accession>
    <name>A0A8H7PH22_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TRM5</name>
        <name evidence="13" type="ORF">INT43_005213</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="10">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="10"/>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PH22"/>
    <dbReference type="OrthoDB" id="408788at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF43">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="12">
        <location>
            <begin position="129"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="256"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="284"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2173793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="439" mass="50091" checksum="7286EBC6BA308B55" modified="2022-01-19" version="1">MPFPPPAQKGMTQLNREVFKRVISVYGVRIPATKVMSFQKQIRGDLFNQPKLKNVVDDNDSKETRLVLLRSDVQSADLENVSDESKKVIETEGLGIAKHTIELTYDYWTSDEILRAIIPEELPEVPSAFTAVGHIAHMNLREEYLPWKKVIGQVILDKNKTIKTVVNKLDAIDTTFRFFKMEILAGDDNMIAEVKESGCRFRFDFSQVYWNSRLHTEHDRLIKQFAKNDYVCDIFAGVGPFALPAAKKGANVYANDLNPVSYKWMVENIRLNKIKNNFRPYNMDGREFIKQAVNDLDQALNTGDTWKTFDHFVMNLPATGLEFLDAFRGVYRTKKDVYEKSGSPKLPLVHCHCFSKSPTPNIDILERIQMATGEPVDAESSYVHWVRKVAPNKDMYCVSFRLTPDIVFAESSIKRKEPILEGGGSAVETKKPKIDDKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHB9</accession>
    <name>A0A8H7PHB9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_005270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHB9"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="324"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="383"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2173850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="506" mass="56485" checksum="74858CBF25D250DB" modified="2022-01-19" version="1">MGNKKSTLLGKKHGKEPKASPATTISSATQSQSRVMMGREYHNVDSSTYVLPKDDMEKDRLHQQHFVVKEQLGGNLLCPETTFPLFDKGIWALDVGCGPGSWVLDMATDFPSSEFEAFDMAATFPSAIHPPNVHFSIANLLEPLKFDVDFDFINMRFFALALRKDEWAVAYSNIYKAIKQGGYFQHVETTAMPDTEDREINEVFNALASLQRKKGQEPLISRQLVGLAKEQGFEIVYDRVVTVEAGWGSRADQLMAETIGQGVLGTAPFLAAELGLSEKAYTMAIEDSDSSDDEVHPPLTTFSHLYSTLENDANGQPGGILITSVAQQVIDGLWIGGFTAAESLHFLEKEGIRHILSLGHFKPHHTDKGIDNKIIVILDAPQQNIVQYFDETFEYIHGILDRGERVLVHCVAGVSRSATIITAYLMRLKQIRYKAALAMLKRVRPFVSPNDGFLQQLRLYQTMGNRVDVDNPEYKKFLERHPNQDEAAMDPVYGHPHSTPTPATKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHK7</accession>
    <name>A0A8H7PHK7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_005169</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHK7"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="183"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2173749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="406" mass="43701" checksum="E341473C31924A4C" modified="2022-01-19" version="1">MVANNQTQVRVSKGIDDTRSELREMAKQIHKHPEPGMEEKFAHDYLTKFLEEKGFQIEKGVADIATAFVATYDTGRPGPRIGICSEFDALPLSKKVVKHACGHNLIATVGVATALGLKTALSDSEYKAGGQIVLFGTPAEEDFGGKNYMLAKGVFKAVDICMMAHPNAGDKDFSRGPMIARSSVKVEYFGKAAHAGMNPWGGINALDAIVLAYNGISTLRQQMVPTDRVHGIITHGGSAPNIIPDHTAGSFSCRSVNRDGLEKLGAHVDKIFRSAAEATGCKAELSWDESPYLDVKNNKVLMDLYAKAMTEAGYSDRNPGVKNPDPLTSSTDFGSVSYSMPAIHPMFGINTASTPHTADFVDAAAQDVAFDNALVTAKSLATAGLTVLEDKEVYNNIVKEFQQLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHS1</accession>
    <name>A0A8H7PHS1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_004181</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHS1"/>
    <dbReference type="OrthoDB" id="431929at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057358">
        <property type="entry name" value="UBL_ZFAND1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF20">
        <property type="entry name" value="ZINC FINGER AN1-TYPE CONTAINING 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25327">
        <property type="entry name" value="UBL_ZFAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="28"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2174161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="229" mass="25838" checksum="B7A017BEF59BFE9D" modified="2022-01-19" version="1">MPTMQEDILLKRHVDSRCQLYLYNPPDKAKQRPCDVDGCKDGDPVIGLVICDACLGLFCLKHRYRSAHSCASESLAQQEKQDRKVAAQQKIEQHLGKRIPTAEKSNQATTKVKKPNLKLELMKMKGKAKGDTSIPLESRMYFTVHFPENSGRKPSPLFFDKSHTIGRMLDQIAKIGNIPNNNHLLSRDDPKRLQIALLPDKTVVGTEHRIEGILDNTSPIIIDMNMNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHZ3</accession>
    <name>A0A8H7PHZ3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquinol-cytochrome c chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHZ3"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021150">
        <property type="entry name" value="Ubiq_cyt_c_chap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007129">
        <property type="entry name" value="Ubiqinol_cyt_c_chaperone_CPB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03981">
        <property type="entry name" value="Ubiq_cyt_C_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome c chaperone" evidence="2">
        <location>
            <begin position="108"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2174193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="261" mass="29527" checksum="347C53B8518E5274" modified="2022-01-19" version="1">MLSAVTRASRSNAARASHFLTGRTNIKSIISPAVCSKIQIGASNKYYSTDSADNAPKKEYSETTKKLVFGLARMMGYYSTSSTAIRASHDLYSVCAKQVEENKKFYLQDCSLPDNFQTWFSITQLHVWLLMVRLRAEDHGKLYIQELVNRFFEDAEDKMRLHGITSGRIINSYVKDLLAQFHGGVVAYDEGMCKDDPVLAAALWRNLFTPTTGNANDLAYIVQYIRRELKILDEYDSEKLNDGRIQFSTPVASFEPSKSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PI07</accession>
    <name>A0A8H7PI07_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PI07"/>
    <dbReference type="OrthoDB" id="2499440at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="1">
        <location>
            <begin position="4"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2174377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="152" mass="17609" checksum="E4F72C02D24C0943" modified="2022-01-19" version="1">MILKVVDVREGSKKADTPVVLWTKKQDGTQSQNQLWLYHDGYVVNVHSRLVLDIRGSLKPEDLDAARIIQYNRKSREDAHNQLFAYDEGRIYCQAKPHLVLDVADKSSDDGVDIIITERDDDRVSQLWSFEEVQAAVDKEKILGFNKSHWWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIK3</accession>
    <name>A0A8H7PIK3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CsbD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIK3"/>
    <dbReference type="OrthoDB" id="3170343at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2174229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="12614" checksum="E1C3B95CE5ABF6B2" modified="2022-01-19" version="1">MDNTQHHDHVKRDAALGAGAGALGGHEAGHGHTGRDAAIGAGAAGLGEHELKKHDQHNPVAGGNPVSRQEARHDQHKVNERAEGKVPLGDKIKGTAKEAEGKLTGNQAKVAEGKALKDDRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIV1</accession>
    <name>A0A8H7PIV1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIV1"/>
    <dbReference type="OrthoDB" id="2417469at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2174768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="90" mass="9242" checksum="1F0BBD701AAF0DF5" modified="2022-01-19" version="1">MDVGNSKQPFGKSSSKHPLGQGLFKVGDYDDEATTGTAPEKHGSFSEKAKSGFDKLTGHHHKDATAGNNPTAANNANAASNAAAPPPPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIY2</accession>
    <name>A0A8H7PIY2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-8 sterol isomerase</fullName>
            <ecNumber evidence="8">5.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Delta-8--delta-7 sterol isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_004141</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ERG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIY2"/>
    <dbReference type="OrthoDB" id="347124at2759"/>
    <dbReference type="UniPathway" id="UPA00768"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006716">
        <property type="entry name" value="ERG2_sigma1_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868">
        <property type="entry name" value="SIGMA 1-TYPE OPIOID RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868:SF1">
        <property type="entry name" value="SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04622">
        <property type="entry name" value="ERG2_Sigma1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2174121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="222" mass="25487" checksum="E16B5FA1C957496F" modified="2022-01-19" version="1">MSVESKQKSSRFQTLLVVLVALIAIFIGFDHIKERFYIFDQNVLQEVAQRNMAKYENNTRLMMQGIAQDLNKEYPGHVALKEEWVFNNAGGAMGSMWILHASLTEYVIIFGTPVGTEGHTGRFFADDYFIILEGEQWAYAPGDLSREVYKPGTMHHLARGNVQQYKIPEHAWALEYARGWIPLMLPFGIFDTLFSTVDYVTLYETFRLYGKATVKELLQGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIZ0</accession>
    <name>A0A8H7PIZ0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_005914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIZ0"/>
    <dbReference type="OrthoDB" id="2330342at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2174852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="143" mass="15948" checksum="C50CDC045156B7C5" modified="2022-01-19" version="1">MVEFTLVAPEPLRFSNSPAESMCHSPECSQADLHDECIFESPIQDVCQYDQHSFESSAYTEFQEIFHSSRYCHRETDSSQLGLISKLVQSLREHVPASPVPRSHNPLPNNATFSTLTNAKRASSCTPSVLTSTFEGYSIAKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJD4</accession>
    <name>A0A8H7PJD4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2175052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJD4"/>
    <dbReference type="OrthoDB" id="10297635at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="275" mass="30559" checksum="4B93A88D68E50FF0" modified="2022-01-19" version="1">MHSIIQAAKSTLCHLERNSTTSGTLVKQDNSFSVPISFLVTIVLPFLTLVYLELARNPAPALHAPITIINFNNPIRSSSQKAKDKPTKPIRNSKTQCVAGKVEMLSTSSPSDLKFCVNNASCCSDKQYLQIENQVAPKKMQVHAMQYKVGKLEITSTYQSDTSVQVLDKVPQSCHIEKFETLEIVTGKVEVLSTDQASDSGKLQICFPETETRTAAVQQTKSLQLTIQREECLVKLVEKTLAHFKVYPAFTKEFRGLLPKLEQFASACNTFEVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJQ7</accession>
    <name>A0A8H7PJQ7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_005846</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJQ7"/>
    <dbReference type="OrthoDB" id="5560525at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21044">
        <property type="entry name" value="Rab11BD_RAB3IP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF0">
        <property type="entry name" value="SEC2P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25555">
        <property type="entry name" value="RAB3A-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="4">
        <location>
            <begin position="104"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="457"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="121"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2174784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="497" mass="56273" checksum="3F785B3CADB25CF7" modified="2022-01-19" version="1">MSVMQGASMTEDTVVVDRTKDIASLYSRLQLSLDGPSSPNASGFSSRQSLSPTNSSPSSPFFHHAPVSCACTHAFSSQECAQCTLCGVPFDNLKEYHMERQERQTSLREHRLQVRELTTQTVRHNLKLEKLRKTVERLQNEITARTADTQSLVSDRNQLIEKLAEEHARLAQIQKDKVDIEHELAELSQNLLEEANGMVAIEQKERQELERQSSQVRLQLESVQEALLAEQLQLTEIREKMMKSTETEKVESFDPENHIDDMIMSEFKDFVATCPAIAIKKLHNIQFLRNCLAEDIEPCLRFPPNARMSSKKLVDAMAANSCFIEVMPTGFSEEQHAQRLTTDQPLRISASRSMIWEMITGNEATATSCMACGRTATLTHRFRISFFDDWACIDRYCRDRLITVCAFYQFVRNIRHGRYRGRSIPDLYQESVQLRLQMILARNGMLTDAMPLPDIPKLNDHSAPASTNTSFSASTDIDTDESVGAESPKIANEPSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJX5</accession>
    <name>A0A8H7PJX5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_005936</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJX5"/>
    <dbReference type="OrthoDB" id="432881at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08761">
        <property type="entry name" value="Cyt_b561_CYB561D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF45">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="12">
        <location>
            <begin position="28"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2174874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="239" mass="26459" checksum="91A5E441F056414D" modified="2022-01-19" version="1">MSESQHYIDERAPLLSQPSPTVETNKRVANLLSVTTQAGVVLFVVLVWSVLLTTPWSLFSYHPASMTVLVVGATEGMSDKTGGIIPTYTAPEKKKGLRRHAFLQALAYTSAILGFTAITHNKALHDKPHITSVHAHFGVFTFSFLFIQLLFGIVIAYAPSVVGGTPQAKSLWKYHRISGYVLLVLIWATAQLGAHAEFMVDNFPKPKLLWLYWVSLVLVSIGIAKRTDVSKWGVKRQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PK84</accession>
    <name>A0A8H7PK84_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GBD/FH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_001219</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PK84"/>
    <dbReference type="OrthoDB" id="2404241at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="478"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2175572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="602" mass="67982" checksum="C638B4A42936F73A" modified="2022-01-19" version="1" fragment="single">MLSRRGVHDQNIINTMLSWDAEKKWLMIMQDHQAEMLAAGAKSQQGDDKSQQPAPLVNILKEKAGEMLNATIDAGQRAVERHSGPVTPGGQYTAQQQPASTQVPAQYYDTSVADRNSPEYFIRKFMEKDLRAVTPSIAGHLEVSLRTRPLELVHEYSWLLKFLDLKGVRVLTSGLSYLNHSSTRKETALELETEMVKCFKVLLNNRWGAREALSNAEAVHTLVFSINCPQWQTRKTVCELLAFLCYCEPPEGHNEVLKGFELLRQHRKDLSIFDAWLKDLEQTLDGRGKMGSLVGANDEFKRLGVFNAPDSHLMEYALSNMILINSLIKVEQDVSARIQLRNQLNAGGMQARILAKLEALDYRLLNLQIETYKVQAENDFEDCFGEEQSLYGNINDPQELLSLILSNLGDASEAVSHLVMTLRAMLLIKGEPTVKTRYHQMITTLVNQLVMDRRGLGDDFSSMYGVSVGNLIQKFSDMERLQSEAEQLAGTREQMEELQREKQVLEQEISRLKAANAAIPYNVDQSAALRYATENASLRALLRTSRNTIALLQGSLEDRNDTNYIDVPEYLSDQYTEGFANQSSKVVVGNEWKTSNRLSQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLT4</accession>
    <name>A0A8H7PLT4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exo-alpha-sialidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_005646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLT4"/>
    <dbReference type="OrthoDB" id="2739686at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792">
        <property type="entry name" value="BNR/ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792:SF3">
        <property type="entry name" value="BNR_ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2176412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="39316" checksum="906ADB6480D4F8AC" modified="2022-01-19" version="1">MEFFTASRRSCFRTLFLVSCLTLIGYVFGVGTTPSLVGSPVAMAPSGGTYPRSTRLSTGQLLGIYTAFSGNNNVITVCQSTNNGASWTDIGTVTTGVGDIDNGYLLELPTTASGASHRRILAVFRNHSRTGTSPNYVYTYYRITVCYSDDGGKTWSYLSQPEGKSPPNGIWEPFMRLAHDGSIQLYYARENSATDQDIVQHISKDGGATWGPMATIAGATTTGRDGMPGVTEFNTGSGNKLLCIFETTEDGPFHVKSVTSSDDGITWGNRATVYVPTGTNNNAGSPQVATLGGNVLVSIFMTDEDTSTHAWIQGAGVKALTSSDGVTWGNKLSVSPPQTNWPGIIPLNNNQMLALFDHNGARSQAIQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLU5</accession>
    <name>A0A8H7PLU5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate pyruvate transaminase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamic--alanine transaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamic--pyruvic transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_005525</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLU5"/>
    <dbReference type="OrthoDB" id="1732682at2759"/>
    <dbReference type="UniPathway" id="UPA00528">
        <property type="reaction ID" value="UER00586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1970:FF:000001">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000012">
        <property type="entry name" value="alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000010">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF29">
        <property type="entry name" value="ALANINE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="93"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2176291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="483" mass="54053" checksum="C0E855483B374F50" modified="2022-01-19" version="1" fragment="single">RNKVLTLESMNEAVKNVEYAVRGELAIKAENLRVALDQKKPLPFSRIINCNIGNPQQLSQKPITFFRQVASLCENPELLQPKNRDTLLKLYPADAIARAEVLLKNVTSVGAYSHSKGVPYIRQTVARFLKERDGSSADPENIFLTQGASSGVQTMLQVLTKDESSGIMIPIPQYPLYSATLSLFNATPVPYYLDEANGWALNIDEMTQNVVEARKKGVDVRALCIINPGNPTGQCLTKENMQQVIEFCSREKIVLLADEVYQTNIYQPDQRPFHSFKKVLHEMGSKYNNVELVSFHSISKGMVGECGRRGGYMELVGIDEKVIDQIYKLVSANLCPNVQGQILVDLMTNPPKAGDESYELYTKEISDIYESLKRRAKMLAACFRNMEGVTCNEADGSMYVFPKITLPKKAIEAAQAAGKEPDNFYCLEMLDATGVCVVNGSGFGQAPNTWHLRSTFLPEEHLFKDFCGKLEQFHASFLQKYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLU7</accession>
    <name>A0A8H7PLU7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pali-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLU7"/>
    <dbReference type="OrthoDB" id="2327445at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF2">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="23229" checksum="A3A0C81242ED2774" modified="2022-01-19" version="1" fragment="single">MVAFPAIFLTFAALVLEIFSLIGNTYNKPFLRSLYFARISTSSETLDFGLWNYCSGDGSGNIQTCSKPVAAFPWNQAPGLNNIDGLSGHERLFLAVFVMYFIATALTFIALAITSLNHYSRGSDLCASFATFIAFVVMLVTFIMGLVIDLQGIHEVSSAMSGASGHLGPATWMTLGATIALLFASGWWLLACCCGGGRRVNAYDKEAAGYRRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLW6</accession>
    <name>A0A8H7PLW6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2386201at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019021">
        <property type="entry name" value="Mms22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28122">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SUBSTRATE RECEPTOR MMS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28122:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SUBSTRATE RECEPTOR MMS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09462">
        <property type="entry name" value="Mus7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1625" mass="186897" checksum="C5AF008C1229770B" modified="2022-01-19" version="1">MSATQKKIVLIFCTNVPMTTSPGRFDSPSLNAYVLTASSSQDCLDDSAIEQLAGQIAADPEALTLHCLSNSDLDADNISNWSTQPIQSAEGAIERRVPETPQRSNTVMFTVGNISTPTNFEKDHPISQSTEQSSHISQSQDGAQMNFGKDDMMIDQEKHISSPRISVAQSLQDHIPAPRLDLFDRLRKALPETSRNNAISEVPMIVDSGFASRSLRKRRDIQLHPFTIEKLHYKAQVGHAHDSHLSQAEIQKRRAIREKYVAQDDDLLARAAEAKNSKQYQNAQRHNRRNTIKQRQVNRPVEHKQSKTTVWQAQRKRMAATYAKKRTVAESISNTQATSNVSDLQQPTSPTVDKSSRRTMQQQLDLLFPEFSFDRAEDDNQYTRKKKRRRVIQDESDADSDTDSVQYLGESQAMDSTNTLDDNTESQASSSTGTKRVNRLEKLKQKRALKGILPMSFTKVFSKELTEDQKMLESRRTAQKQNHRKRMESGSLAREVYELSISSDHESTNSPNEVAHTSDIFTDEESEGENENNAVWSLDDWLGEEGHNVDLQEDLQHARREATTDGPVILRDKDPIDRMVIRSSAGKRVSNPSRRATASTLKIRKVSRYSYNRSVMTRAARGTKKSTKRRTNTVASRLVSKQSFRHERKGQDQPHIWHFMDIRKTRNPSPATPNPDTYFEAEDEFFRQKGNEDKDLPTWVKTLLQARNNMKKLDKDRPRLSRPIIPSGIGPFYRSVSDVTNVNWWQRPGKRRLMTDVLENTEPTQIEPNHFSVHESLPSAGEEDVQIINPKVPANKQPASRKIMVGTKQSRLFEDHGFSKKAGPSNLSSKTLMLSARNTEPINIVKMRHKERKAIPKRGPSQSQINFIQFLNDTRDFPTTYSFRESSIDWHLPSNGYINQGFLKNLEDRKVSSESSLKYVDMVTNSSIFCVFGISFDINGFSQQELEKCISSFFLTTMKTLQNTVFQRSIVNSDTFHEELFNFFAFITIWLAYWIPLVDARERELCISFISREIMSFQKRLMRLTNLQTILNSRDPAASVDVVVIQVMLLWFIYSTDWEIRIQRLESTTHLRLPSQLDLMLALLLWLGPDRSGNNESALNQLILETWICYLHSLARTKPLSDPLSYIIEQVHKGCVSDGLDNWKTSEMMWQWISVLADIYHYDAQFLHADRINVDHLWSAIHRVLQYNTLLIGEGDCAYTSISQHMNISTNELMDEYIRALFCRVHQLCKYYPSSAIHDTLLVLQSFYLNRRFQDLATERDSSFPEFFIDFMGHIPHEVASQDTCFHIFLKTLCITLQNEQASLSSDTDKERQQLRRFLSQLAPTHVMTIRKDDPLSGKYSALGNHFNLNMLFAHVVSTDIQRRSILQAKSFLNFHDSDHIARKMYFEAFTLLSRIYAFHEDRDGLNSIVKLLNERLGYLCDEFSRMQSHQSMTKHGFFSAEDWQADQIERQELIESGFIYIWKIVRDAVSMVDDTAEWFEVAVLSIDKAWSSVLDKHKPFAANTRLYAVNFIRSVLTIRDQRVARLKDQSLHHNIVDASLSSSLRSGDSQDFDMFDDFDYGALNMDIEKVYYDDTDRMLAQSIKSWVLEALQQLQPQISSDDELQETINLAISESLRLLTDHHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMG8</accession>
    <name>A0A8H7PMG8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lactate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_007563</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMG8"/>
    <dbReference type="OrthoDB" id="2266445at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015129">
        <property type="term" value="F:lactate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015295">
        <property type="term" value="F:solute:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003804">
        <property type="entry name" value="Lactate_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30003:SF0">
        <property type="entry name" value="GLYCOLATE PERMEASE GLCA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30003">
        <property type="entry name" value="L-LACTATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02652">
        <property type="entry name" value="Lactate_perm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="516"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="305"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="322"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2176909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="627" mass="67413" checksum="E142A668B4C537AD" modified="2022-01-19" version="1">MVYIPTAPTNGTTDGLFVQPLAPIGGSLVGSFFVGLIPLIVVLVMLGGFKMPAHYSSLVGLIVCIFIAIFAWHMPAQQAFESVGNGIVYANWPIMWIVVNAMFVYNIAVRSGKFELFRRWMISNTPPDKRILLLIIGYSFGALLEGVAGFGTPGAICSSLLVSLGFDPIDALTYTLIFDTTPVAFGALGIPVTTLATLTGLPAKSLSQMIGRQLPFISVCLPTYALCFYAGWRDGFLACWPAAIVAGVSFAGTQALFANLVGPELPDLIAGLVSLISLISFVQFWKPPYNEKYVAVMRVDGADEAMTNDPSRRRSSQSSKQEVSEHEHAVDDDMNPQHHDLDGSGPEVEKAQHASTDSNGVTENEGQYVKPANAAVVKPTLYEALFAWLPWVLIVIVVIIWTFAKVSAVGQVNVAWPHLNNQVWLTLYGKKYTAIWQFQPLATGTAILVAGVIFLICVLLTGEHISIAWLSIADTAKQLFLPILTVSFIMAFAYLYNYSGIAYTVGLTLSSVGKAFPFLSVWLGWLACFLSGSDTSANSLFGNLQVVAAREIGLSPILMAAANSSGAVTSKMISPQNLTTGVSTIGLQGKEGLVLRRTILHSVVMCLALGVMTIVQQYGTPGIIPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMZ9</accession>
    <name>A0A8H7PMZ9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_007560</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMZ9"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF8">
        <property type="entry name" value="GLIS FAMILY ZINC FINGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="828"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="861"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="891"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="196"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="264"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="472"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="588"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="681"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="910"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="964"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1021"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="474"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="513"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="685"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="718"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="732"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="749"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="769"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1023"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1058"/>
            <end position="1117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2176906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1117" mass="122978" checksum="5BC72CED133B44D5" modified="2022-01-19" version="1">MELNQQLPDHSTQLMGDGQAVPDSSPNHEHIQQLIHQQHQQAEMDRQVATMFAQQTGQVASPANTDHHHSSTQASPVQPPSAQSTRNLIDQQLEAVAKQQGQNEAVMSQLLFIGQQHGNQLMVGGGGGGQQHSALPPNLMEKVEHVDHSAHDSNLSTPHGSNLSTPHAMPMPSHDAGNLMHQQNEAMHNQMLVNASQSVTPQSDPGSMQQQSAPPGSSHAGDHQGQQQHPSQVLPNGQNVFDAGLLQSMPSSVPLNEAVLQELSGQSQAVHQHQQQQQLQQSPVTNQSQILSNPSSHTSTPHLNTQELNSQHATPEQQHEQLIHNLMPNVSHGMNPADSEAAAMQQAHQVAAMQQAVAQHVTAQQMVAAQQNTPDMVYDGDMKQQQSSHLNNMMPVGDSQNYTNNMMSCKEQQIPASHVVPSQMGTPMPNSVQDNMMQHVHVDPQHTHQNAQPYSAISQNMMESAQAVHMHSALMQQQQMQQLQHHIEAMQTSQAQQHVQQHHQQQHQHPQQHVHQQEQMVQQQPQQSTEGQSHGTKRPLESNASSQQQHARKSRRHTVSTPYPSHLNLGNKPNLYIDTASLQRQPPFVPIVPSQMGQSPTANHGASLPGSIASSPQETKYNNLGHINLPPRPTLAQMNLETQSTATLSRNIAQAAQVSVKEFEHMTREQLIARLVQLEQEKRGNSPSSNSAQSASTPIPSSLQQQQQSALPVEVNHVDNTQQPESRGSNMDASVTDTSTNADDDDDGPSTPTDNNTTGATQHDNDNKEDGDDEDVDEDDEEDGEDETPKEEQKMQCRWRECGLVCDSLSSLISHIGEAHVGSGKASYSCDWEGCPRAQKPFTKRHKMYNHLRTHTGERPYVCPREECAKRFSRPDSLTTHIKTHSNVRPFVCTAKGCKKAYYHSRSLKKHERTHAGHETNQVGPPPSSNNLGYIPNPMDPAQAEAYGRFPPRPYLQSPYTAQPIPTPDKMNENQGYLGPPEQSPINVTQFGPMTPMNAYGQPGQSPGGQIYSPMVALKYNMPDSQSSTPGGQQLQTPIPTQDYSGNNGGMPMNAGSQQQQQQQQQQQQQQQQQQAYAFGNPVPMDQLQQQQQQQNAAYPPNNVPAPNVASQFNYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PN88</accession>
    <name>A0A8H7PN88_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PN88"/>
    <dbReference type="OrthoDB" id="2385347at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="594" mass="66861" checksum="1335B94F3C21C56E" modified="2022-01-19" version="1">MGEKSIIETDIYVPQRLNPDELAYKFPPASSDTTEELDEMLSQSQVRGSSLVVWDNESDTLDSNPGATQCDFSSVRLNAGIFQPKLSWPSSISVDDNSVTAYSPSSDNYKLIANHKAIASWSDRPPVHMAIQEDLSQHSSGCSVINDDEDSASVCTEDFDNWIQQAKYSDQNLQNDNKALSTSSIAYANGVPAAKIGVAANSIAHSDITLDRAAHSASRSPELVSKSSNVNSSAAEVSYDAKASREETSRRANNVETHFPQYTNLPDTVVLEYKDDRALIVESSTREKDMENELESETILLHIPSTTSDATIRNVAAIKIQAIWRGYQERKLNPPSNTRVMMLLMTLSTKFQAMCNDTADRKLRSLKHRILQESRFRMRSERQLQKLGDVNRKERDELCRLLEAETATLESHERLVRETSEKADLAWQHIQDEKLERENLERVVHLAAKEISAQNEREINRNKDMDAIYRRVEKLASELKSLKQEQSSSYSRVRRSISPTSSTKSLSLTSETSSQEARAVYKHRIRPSAVPRMESEPYMSKTKQRSYSNIPSSRDIAKTVSNDHKYKTVPLKGKSLIPTNSTTTPLRTNRDSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNQ1</accession>
    <name>A0A8H7PNQ1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_005731</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNQ1"/>
    <dbReference type="OrthoDB" id="2538017at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15967">
        <property type="entry name" value="Nucleoporin_FG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="268"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="110"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="159"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="371"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="417"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2176491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="765" mass="79551" checksum="4FC02C3E7C94466C" modified="2022-01-19" version="1">MSGRKPVFRFGAGGSAKNTKDPQVNFVFQLPGGGASTPGGFNFAPPTTPTAATPSFNFGAGASNPPTTPGFGNAGPAFGAPAPTTPTANANPPSFSFGQAAKPPPMNFGAANTSQPSAFGSAQPGSFGSQPSTPTAGFGQAPSTPTSAFNFGAGAIATPTASSPFGQSQNMSMNTQTPAASASPFATNTSQPASAFGMSSSNSMQSSPLRRAVSDVSGLNQNSQSSLLNKSGFGAGSPFGGLASSGTTAATSAVSMATSTAPTPSFSFGGANSTSAAPTSTATSAAPATGFSFGPSTTPASTPKSEAPKPAGGFSFAAPTTPTTSSSAASTSFFSFSKSAESEKKPAPSAFANNTSSEPTKEAPKFSFGKSEPATTSTTSAASQPSTPATSTPFSFGTSKPTTTPSILTSKPADGGSAAPAFSLTTSASTSTSTTTSAAPASTGLPKFSFGAASDKKTDASTTSSTATTSAPAIAPVAPAVPAQPSEFSFDKILEQMKVVSISMPQEIQFSLANAGMPGRTMGQNALIMQSTNFPIDKIEPNTRHSELPDEARNQLDELEKYMKSEMQVCGFLKKNKMISKAEQIEKVKTDTESMIKQMEGLHSRLKGHAEVIEQLWNGVDYQHRNAVQASEIVDNYKNREHQSRWAFGYGVHNNYFALLARNFEIRLDRYRQSITEIEATITSMSKHKAISPKDVTDTIRMQHDSLLRATGRLVEVHEDLDSHKRRYRQYCELFYGQYTNPLPEKADNQILDFKEHLKPLPSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPL1</accession>
    <name>A0A8H7PPL1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPL1"/>
    <dbReference type="OrthoDB" id="2339532at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2178079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="115" mass="12446" checksum="A0A3ECF20B3EC6E8" modified="2022-01-19" version="1">MTIFQLPVFGSIFSTTSRPDNLRKSIGPISAVLKRKQPFASSAHRSNPHKGGPNPSEPITEGFVLNSFPRPNLSPTLHMRLGMFGTSTATADTSKDKQRKCTNCAGPHSSDFCPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQX0</accession>
    <name>A0A8H7PQX0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQX0"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034586533" evidence="1">
        <location>
            <begin position="18"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2178814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="66" mass="7274" checksum="9861F11B1D8B0154" modified="2022-01-19" version="1">MKTLTLIVLLFVSSIMAVPSYPDELELSKRMGCSACCAAQLKRSEIQELRERGQNCCTCCLPDGCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRL6</accession>
    <name>A0A8H7PRL6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pyruvate carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_001770</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRL6"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="8"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="124"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="565"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2178923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="647" mass="70662" checksum="07F0E3EC6115A601" modified="2022-01-19" version="1">MGNWRQRRNVKLLVANRGEIAIRILNSATELGLDTVAVFSDPADISHCRYANTSVQLSGGPLAFMKPQSLLDVALQTGANAIHPGYGFLSESSEFAKLCAANNILFVGPSPKVIEELGDKLSARKIALDANIPVAPGTKEPVQSPDQVCRFGDQYGYPIMLKARDGGGGRGIRMVHDPKDIESVLQRCINESPSKQVFIEKAIVGAKHIEVQILGDKEGGVVHLKERDCSVQRRFQKVIEIAPSVGISSQLRTRIQESALALAKHIRYDSAGTVEFLVTPFDQKFYFLEVNPRVQVEHTITEEITGIDIVRSQILIALGETLESLAISQNNILAVPPMVSIQARICAEDPHKDNMLSVGKITNVEFALGQGIRIDTWIHPGSVVLPHFDSLLAKVIVTAQSFPIAVEKLKRVLSMMVIEGVQTNRKFILALLNDEQFLHNETQDINVTFLETRMSYLLTSSQKLKTATTSKPQNRSVNVQPISAPGSIQFKPGDVFNIELSSTDKSDKATKQIHSIKINDISVNDFPDHFNSKIELATSSANSLGSQLNMKINRRTAAADSSLRRKAIGDAGEIACPISGMVTEVSVKVGDKVEVGQEAFVVSAMKMETVIKSQLGGRVKAIYAKVNDLVDSGDLIVEIVETKDSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRX1</accession>
    <name>A0A8H7PRX1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_001808</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRX1"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF30">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="59"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2178961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="362" mass="40001" checksum="B08C0CDD28AD9AC8" modified="2022-01-19" version="1">MAGLANANRSGSYQGAQHKTYVGHIHYAAQKAQVGKDSPLGARDMTSHWVNLQVQSVEQLGGSVVDSLLEFGEYRIRGTQIDVTRLTRNVSSDKSKALEEKGVEMVQADLNDKDSLKRAFKNADIVYGVTNFWDPEVLKNPSLEAKQGKTLADAAKESQVRWILWSSLSNCTKESGGKIKHVIHFDGKNDVEEYINSIGLPATFIYVGCYMSNFGSLLPLVPKDDQSQTLTLPEVKEDTLLDLVDAAGDTGPIVRAVLKNKDKYVGQKVPVVGDRLSMKQIADTFTRVTGKTTKFQTMSQDTLKNQFPYLNNDEFLDMLRWFRDFGYYGNLYGPDGSGAVEAASATGVRGTTFEEFLKKSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSC3</accession>
    <name>A0A8H7PSC3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_001721</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSC3"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="267"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="475"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="507"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2178875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="536" mass="61482" checksum="98E2B1B49C4D8A07" modified="2022-01-19" version="1">MHQLLNETINFLERATEPAEWSLLLGPRIFGLASRYVTNDVFIAGFMFYVYSLLQTAFNRLYEDVSYFVQSFLYASIRIEHEDPLFVCIHEFLSEKVAELPRLRVAVARAHWESEDSDAGAEAGERPTVSLSPPLGSINFIDYRGRRLQIKREKLSEGGSNVDEPFKAFLPQTEIIEIRIRFGTVNTLRQILEEWKDIYYRKKYGKCIIHRYCLQSWGHWEWDSSMVKVPRRFDTVVMKEGQKEDLLQDIQTFLSKHEWYEKRGIPYRRGYLLHGPPGTGKTSTIEAIAGELHMNVSIISLSNDMEDSRFMASLQSKPRNSILLIEDIDSVRISSNDDSKNNSRGGYYEKGLTLSSVLNALDGIVGQQGSVVFLTCNDTTKLPPALLRPGRIDKKLHLGLADEYQIRSMFERFFEVSDDKTLEKLMELLPKDELAPAELQNFFMIYSLQDDLKHICDGVPAFLEGVRKDREQARLHAERTKQKRDIYGNLANPGDAPPTPSTDGEEKEEKEGEKENNNRRIIIDVKDDGQLCMASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSE1</accession>
    <name>A0A8H7PSE1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GTP cyclohydrolase II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_001857</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSE1"/>
    <dbReference type="OrthoDB" id="57939at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022163">
        <property type="entry name" value="GTP_CH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005536">
        <property type="entry name" value="PRK07198.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259:SF2">
        <property type="entry name" value="URACIL-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12471">
        <property type="entry name" value="GTP_CH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase N-terminal" evidence="7">
        <location>
            <begin position="88"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="6">
        <location>
            <begin position="327"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2179008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="55410" checksum="AA80BA87309F9B85" modified="2022-01-19" version="1" fragment="single">ALHAPIFINSLLRKRLAKVDTLMLAQSKNGSSSALKNEADNKLTNSPALSSSAIPPSPSIIPMQQDENVDKASISPPQSVSAKSLYTQRVILTTYPGQHGINPVALDWGAADAHKRGPVVASRHPGSIKLRNAIGAYGGSYCVYRALAVAIGDLPSNHRPNFEMTEPTFNIGPYPNWVDPTKIVSLDPWGHMISTLYRDQINNGLDVRVSWTCRPTIAITKAHMKLAEMEMSAAQGRLTVDGKIVINDIGELAVSKAAVEPVWYLPGVASRFGIEEGTLRRALFEDTGGMYPELITRPDLKVFLPPIGGISVYIFGNPAYISDPSKKLTLRVHDECNGSDVFGSDICTCRPYLIFGMEECVKQAQEGGVGVIVYFRKEGRALGEVTKYLVYNARKRQEGGDTADHYFLRTECIAGVKDMRFQALMPDVLHWLGIQKIDRMMKHDAIVDSGIPILERVPIPDELIPADSRVEIDAKIASGYFSTGQALTNEALAKVKGRDWEDIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSQ2</accession>
    <name>A0A8H7PSQ2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_002050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSQ2"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="277"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2179200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="407" mass="43138" checksum="358D53B818754C73" modified="2022-01-19" version="1">MNSGITEPITEPPKASPVVVLEAGAGGSGDADGSGDADQSSNLEVAQPVKLKPMQILKQNAAPIAECLFIGLFLGLNDGQFGIILPSIKEYYNISDGIVSLLFICQAVGYLIAAFLNGWIVEKLKQKGALYLSGALSVVAYVLLLLGLPFPAMCCFMPILGGALALMDAGANVYPSTMPYGTTLLNLIHAAYGLGSLTGPLIASAIFASHLSWKTSYMILAGIAALNCLFIWLSFRNVELHEEEEPDVQNSGDATSADAKPVVRRGRFAQSVRLKFTWLCAIFLLFYVGIETTIGGWGYTFLTTARGGDTVQMGRVMSGYWAGLTVGRVILGHITGMFGEKRMILVYLVITCGMVILVWQATSIGTDAAGLVILGAVLGPMFPTAISVSHQVLPKHLHATAVGFLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PSU4</accession>
    <name>A0A8H7PSU4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PSU4"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="32"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="109"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2179130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="177" mass="19903" checksum="D2A2DDA55B5ACDDF" modified="2022-01-19" version="1">MCTWLEITRLKLTESLKFGIFSSSRHSHLRNNLMVKWKEAFSMYDKKGNSTVSSDNLGDLLRGLGQNPTQAEVRELIKSLGGSDKHDVDIDFGTFLTILTRPDGFKPAGTSQEFIQGFQVFDKEGDGYISAGELRYVLTNLGEKLSDEEVDELLKEVEVSKDGRINYVDFVTLILSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PT97</accession>
    <name>A0A8H7PT97_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VTT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_001969</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PT97"/>
    <dbReference type="OrthoDB" id="3364966at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045014">
        <property type="entry name" value="TM41A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220:SF21">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 41A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="7">
        <location>
            <begin position="144"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2179119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="331" mass="36816" checksum="6AC7873C5B7D2AD1" modified="2022-01-19" version="1">MATIALDKISNEPNNMIVDADSACSVDIYTSKPVTPSPAALYELDEDSEINECIYGQPIVVKSSTTLKNIAIRMFLFTLIAVVSLIFSLLLAHQTLGLGIPHTLSEMKDFAIQLESISQETWTGYLHVTFFFAVLYLWQQGFSIPGSVLLNLLGGYLYGSFAGSLWTSLLTAGGATLAYLLALLVSEPFLDLNWVATRIEVIRTQVNDNKKAGGLFWWLLFARLFPFTPYWFMNMSAPLLDIPIMPFFMSTFLGSLPYNFICCQAGEVIGQITSTADIVSMSMILKMAFISLISLIPVVFGTQIKRYMSRRLAIKSGNIDLEYQQLPQRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTS6</accession>
    <name>A0A8H7PTS6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_003753</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTS6"/>
    <dbReference type="OrthoDB" id="354826at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000354">
        <property type="entry name" value="AGC/YANK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000469">
        <property type="entry name" value="Serine/threonine-protein kinase 32B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF30">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 32B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="8">
        <location>
            <begin position="264"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="363"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="431"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="532"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="578"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="614"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="630"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="673"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2179966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="693" mass="77622" checksum="3359294F86188A66" modified="2022-01-19" version="1">MSFGSFSSSRGKGAFGKVRVVQHKATKQLYALKYINKAKCIKMRAVDNIISERRLLEQIDYSLIVNLRYAFQDDENLFMVLDLMLGGDLRFHLERVGSLPEEQVRFYAAELALALNYMHRRRIVHRDIKPDNILLDEKGHAHLTDFNIAVHYSEKKPLTAVAGSMAYMAPEVLQKKGYFYSVDWWSLGIVLFELLFGKRPFRGKTNESLTKSITSDPLKFPDNAHELASPACLDFVKGLITRDPTQRIGVDGGFEKLRNHGWFKGYDWYALERKEASPPFTPDSKRANFDPSHELEEILLEDNPLKVRKRSKPVASNAGGSIKSQISQNPDQPPEMHIMDTKFLIYDFTKPHENTMRRQEFEQQRWAHKAPQVKTDMPSRPVMDASVYHKPSGSTKSSVLDQLNSKPAPPITAGDILKMDELARMARVSGSHSTDAEFRPPSGILSPSHLDSKLYQRPVPNPSYSTPSIQKRDHYIQQEGGIPPSSRPPQTGSRRYSEPRYNDELDPFVDNPSSPGTAPSYTSDYQVTSDQRQYDRAEVIYRRRLSEESSNVPPSPNPSETALLKSHRYFTDASSQAPMPPPQQPPPPIPSHLPVYLPHRVSSRPSGEKLNMISASLQSGFASSQSSPSTPIPAGPPRLPPTSPIPPVPSSGFNPPRPAYSSSNSSSRSAMQPLPPPQTSPPPIPLPLPPLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVT9</accession>
    <name>A0A8H7PVT9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_008815</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVT9"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000638">
        <property type="entry name" value="Transmembrane GTPase Fzo1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF0">
        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="711"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="234"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2181232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="832" mass="93437" checksum="5955983959CA1B5A" modified="2022-01-19" version="1">MAAQYLGAKGSSASSFTQQKIRHLSGDQTSTPDYFGVGKRSEIWNPHREQPAKSPATTGATNVQQHRLNVQQEQQIFADKSTRLLELLTKTSSVISDLREFNGRHMVYYPKIAAATNGTDHVSLQRQALERSQTLINLPVEPELKRHMLKRSNSLGGTEVEQTHAQNASDNHRILTSDVANAFRSKLNVLNLDVKVGHQMANVNSLAQESITALLEERLAQSIAHIEKIHKRVADTSSKVLVTGDLNAGKSTFVNALLKREILPSDQQPCTSTFCEVLDATINDGVEQAHAVRDVAAYNRTDPSTYDVIELRHLYKTVIEEDTPYKMLKVYTTDRRQTEESLLHNGVVDIALIDSPGLNTDSIKTTAVFARQEEIDVVVFVVSAENHFTLSGKEFLWNAANEKAHIFIVVNRFDSIRDKERCKRLILEQIRQLSPATYADADDLVHFVSAGSVDLEEGSHKLDPEEFARLEERLRAFVLENRVKSKLSPAKNYLLNVLSDLHVLSESNHEEANKDLQHASSELEADKPAYERLLAARDHIFDQIERIAEDSVRGLQTLANTRLDTAVEQIESAISNLEYPGLFLIWQYAQDVADSMAHSLQKEVKALEAYAKDKTHETIGQIHELGTTEIGEYSQIVDVDSMFLKSRDRRIFVEIEATDFFDIDFNDKFSVLSVSLGAATMVGGRVMGVKNVVSSIWNVSNVVGVTNVRRWMVPVMGFAGVGLVVYVVSDMRHAVERKLARKFKAAVKDSNHNEGQSYRIARASRKTLRVEGWELQTRFQKAVDQKEKMRSDMVKKAQMSEEAMKYFSNVITTATEVRSKVEAVNTQEVCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PY96</accession>
    <name>A0A8H7PY96_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PY96"/>
    <dbReference type="OrthoDB" id="9996464at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041646">
        <property type="entry name" value="VC0807_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2182023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="324" mass="36268" checksum="49FB8180C41BA1B8" modified="2022-01-19" version="1" fragment="single">MTVLEDPSLTAKSNEKPDIEQDARSMASGTQTSLALDDISSTINPENSAKESMKMDCSVDKGSDDTLAEDEKNKEDSEVKEEDIGPPLTTRQRRKKAILRTLYIIVFNAALPIGLYYALKPHIPPVWALVASTAPTIISVIVQAIVARRLDIFGVAVIFGFVLSVILAVVSQDPKLLLLRESFITAGVGGAMALTLIPFRYKNFELKPILYYIAKDMIPMTPVKHTDGSSEARVQFYWRTSSKFRYHIRVLSALDILTLECEFGLKLFYILHFDLDRTVVLSNITLTIVGIVSMLCTIYYALWLRKLLKKEEPELFAKDTTARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0B2</accession>
    <name>A0A8H7Q0B2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0B2"/>
    <dbReference type="OrthoDB" id="2401798at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="196" mass="20149" checksum="2B8768DD416F8783" modified="2022-01-19" version="1">MVSIVSAGQLAATGTFEIVSPTPQSIYVAGQMLPVIYVVNSDIVANKALELSIFLNPAEPKLNISTMLITAKADVGASARVSKAPNGVFAFEHAVNFNIPKDAPAGIYNVVFVDSVMQVNTTVPVAIKAAASPSSLTSSMGSSGTPATATNHINNQANPAQPSSFLASSASHSSISVIFTALFAALTTLHCTDNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0N6</accession>
    <name>A0A8H7Q0N6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_006160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0N6"/>
    <dbReference type="OrthoDB" id="18679at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15886">
        <property type="entry name" value="SNARE_SEC9N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="305"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="261"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="308"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2183165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="368" mass="41362" checksum="92C5C9C9C501B207" modified="2022-01-19" version="1">MFGRKKKSTNPFEEDSSPSPPPPQQGKALGGPPPGHYAQRQPSYASSNPPPSYRSNSQSDLSDRQQLFGDAPSRSRFQGRDQGRDQGRDQYGSNSSYQPSDRYGGGADRNRYNGSSSYGPGYDQEGQEDAYSSSRWGEDEADQEVAGLKQQIRDVKQDTLASSRNAVQKIREAEEAAGNTMNMLGEQSSQIASVDRNLDLAKAHSDRASSKANELKQLNRSIFIPVIKNPFNKASRERKELESVRQDHAAHMQERNAIRQYEYESKERIDRAQRAAGRQSANSGFRGRSQSDRQRYQFEADEEDDAVEDEIDQNIDFLSDSIARLKNNALTMGEEVESQNKQLDKVTRKVDPLSDRLAMTTHKLNNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0Q6</accession>
    <name>A0A8H7Q0Q6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BCAS3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_006406</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0Q6"/>
    <dbReference type="OrthoDB" id="25778at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045142">
        <property type="entry name" value="BCAS3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022175">
        <property type="entry name" value="BCAS3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048382">
        <property type="entry name" value="BCAS3_WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268:SF0">
        <property type="entry name" value="BCAS3 MICROTUBULE ASSOCIATED CELL MIGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268">
        <property type="entry name" value="BREAST CARCINOMA AMPLIFIED SEQUENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12490">
        <property type="entry name" value="BCAS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21034">
        <property type="entry name" value="BCAS3_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCAS3 WD40" evidence="3">
        <location>
            <begin position="455"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="BCAS3" evidence="2">
        <location>
            <begin position="806"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="839"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="981"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="981"/>
            <end position="1012"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2183400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1146" mass="125422" checksum="0243FEA909DDF978" modified="2022-01-19" version="1">MTDRIQTSQQGVRAEPKFLRDPTSLESLSSGISRISTYVTSNLPKKRASLPSFLSPFDPQYSHQYMYGVPQQITAPMSSEVAESAASEMDNSFKSYTTPTFAAFDSLTCKKKDQKGQSRLKCLMVGYHDGFQIWDVNNPDNIHELCSIRDEKQFANVTTIHNLVNPRHDKNHSHGRLDDVFEKHRPLIAIVSNPSVTKENSPNDGQQEHHDHTSATNPMTPPTPAAIPCKQCKVDIYSLRTHEVVKTLENFDVDESVEITEIQSNDRVIVLAAVGQNRSRIHILSAASLEQFAPPLIDVFHEVGKNPPFTLGSRFLAYATSTPVLNTHQGTSPGSSSISGASLGVLSGEKDVKDAAKEVAKEVVNGVKALSEYGYQTLSNYFSNNPSADMANVPPMMPNAAPRRDLPYGLKDPNDRTASGHLPSPSGAISKKGAYGGMVMVRDILKLPSTSTKNLSASVLAHYRPHTHPIMILSFNAAGTLLMSVSRQGHTFHVFSILPSGSNTGSTAHLYSLLRGYTDAQVEDSKFSTDSMWCAVSTARGTTHLYAINPDGGRPEILGHVRGKARNSYAGFAVPRGLQQPKPVSQGPAVRIKQRTPMPTLEHTKVENGAYNSAAYPGVIHPMYSNQYPSYVVPHPMPPASFQVEPKAARAKLITSFLSTTKPTFLFRGNTRQQPADQKPSIVNMNTLASLTSPSLRQIRDKASSLGSMISTLSGANGQTSNNSSPQQKGRSWINPNDNNNDNRVFGFEEEEASLEEDTTKVIGDEVGYQDIYSFHPDGILTLHRCCIASGIARRRENGRVVERIELSVRQEDIAEWRVARSTDWDEIKTPLESSFTLPITASNKNGQEKAGGGKSKKKKQGGAMSKPLESRTSHHAWLSNAEISTYPVTPDDHNLWSLPQFSFQTYEGSDNKKIQAALAKGRIPATHRLIVKRDMPEPISRRVGRVNRTMARNAQKDEDGDFEEALAELEDNLSKAMQTNFSSSPYNVMDSSPVGSKRMSSSAGNTVQQYRPSAERVPSLSFEDAYLINMGGGATGFETSGSMPGTGFTPPISTSYSSPKGDKESALQNSSLIRFDDDELLNASLDLSEKDLNENDAVQVVAENPSRDLYNPILQGDQVFSPDGDNEVAYPSDSIILPAEMPESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q182</accession>
    <name>A0A8H7Q182_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the free Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q182"/>
    <dbReference type="OrthoDB" id="15735at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033745">
        <property type="term" value="F:L-methionine-(R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000008">
        <property type="entry name" value="GAF domain-containing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000614">
        <property type="entry name" value="FRMsr_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF15">
        <property type="entry name" value="FREE METHIONINE-R-SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01320">
        <property type="entry name" value="UPF0067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="65"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2184544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="177" mass="19528" checksum="D9F266E4CF0812B9" modified="2022-01-19" version="1">MHPVPATTNPNRTKKEFYSDLLEEVQAFVDGQRFWVTNLANVAALIYHGLHSLEEHKNKPVNWAGFYVTDPKDDQKLILGPFQGKVACTEIKFGKGVCGTAAATKETQVVKDVHEFPDHIACDSASNSEIVVPLVLSSGKLIGVIDIDCEELEGFNDEDKVGLEAVAKVIIDSCDWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1V1</accession>
    <name>A0A8H7Q1V1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1V1"/>
    <dbReference type="OrthoDB" id="2244769at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="252" mass="28331" checksum="ACD1AD659EBA9202" modified="2022-01-19" version="1">MPNKCCCIFPLRGGVITVGLLIAAASVALLIATFVHKNPMIIHLEIVNPVLPWVYIAVTGKTQCLNSMFRFHFGKSHTHYRFLPLKLLEPWLLFWLFFVIVTIWQAVDFVLAIVNRGRTTDACEQANPAGNATTGGNSTTPGFLGVSVGDTYGLSNCSQAVEVGLIAIAVLLFVGTLFMIYFGTVINSYCRRLRERQLGHRLRDHSDWDESVMDLTNAYREDARNAPRYQMTPLNQKKTSKFKFPKINFGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q253</accession>
    <name>A0A8H7Q253_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_006672</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q253"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="37"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2183664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="436" mass="47477" checksum="B8946D2998E41AB7" modified="2022-01-19" version="1">MFSSEEKASDIDVAHTYSADDSSSTLSDLRAERPGQGSSIWAYCNIVCVVAGTGALSLPYALRQGGWIGLFILGLSWLMASYCGIILIRCLYANGKTRLDSYYHVGKAAFGPVGGAVVFFFNVILLLGVSMLYIMLCGSNFSSVILKGTGAELTPAIWKIIWACVIAVPFVFFRSMKEIGIFSFFGLISTFVCVVIVVAVAVNDHNANPVPVEHDSVLWDQFPIALSSISFSYGGNPIYPAVEASMRKPKQWTKVLIAGLTTCMGFYFLCAVPGYYIFGNTVESPIYASLPDSAAKTAAAVIITIHLILATPLLVTSLALDCERMLHITPEYRGKWSERGLRLVFRIAMMVVVAVVAIFVPYFGDFMSMLGAVANCMIIFAFPVLCYWRLTGIRNKPIYELAWGFLCILLGIVGLIFGSIDAGRALYSDFHPAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2F5</accession>
    <name>A0A8H7Q2F5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2F5"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF184">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2184683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="48054" checksum="BCEFA82A713E6FBF" modified="2022-01-19" version="1">MTIQSAANLSRFSTLHHKSLSVMAKDLSNSDTASENGAVKVSDVDKIQLKNSEPGTGSQFKEFLKTVIRFSGDLSSLTCPAFFLNGLSLLEYGTYWGDHPQFFTAIPASSEPQERMLEVARWFMSTLWGSYASRCTNGLNEKKPYNPVLGEQFFCNLGEVTCICEQVSHHPPISAFYLEDEKAGISLNGHCGQKSKFKGTTIRIDQVGRATLYLKKWDEQYVLDFPVLNIKGVLTAAAYIDLSGICTIASTSGAVSTIEFLPKPWFGGEANCIKGSVKYKDTEYYTLSGRWSHKSYYSNAGESAKHLLFDADAEPMAERKTAPLEEQHEFETHKLWGPVTDALKVKNYQIANAEKSKIEDRQRQLKKERETTHETWEPSLFEFLEDKSKKDQYVTRNTELTEQMVGHHDLDKGAWTYSKSLHLRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2L1</accession>
    <name>A0A8H7Q2L1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">SAGA-associated factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">INT43_000589</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">WA0000067209</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the SGF11 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2L1"/>
    <dbReference type="OrthoDB" id="1865897at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070461">
        <property type="term" value="C:SAGA-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013246">
        <property type="entry name" value="SAGA_su_Sgf11"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF9">
        <property type="entry name" value="ANTHRANILATE SYNTHASE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08209">
        <property type="entry name" value="Sgf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0822">Tryptophan biosynthesis</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="19">
        <location>
            <begin position="404"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="18">
        <location>
            <begin position="592"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="230"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU261113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG2184676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="869" mass="97066" checksum="A1409DF868A1EA12" modified="2022-01-19" version="1">MIPKNRLYKKLLNERTEKIENLKSTYKVLSKKIPAIEQANDSNLKSGSENNISVDSKATMNLRLSDLPVKTFEREAHAFYVLTYFLVEYTVNETGCDIFGNSYTSNNLPSYECVNCHKMYPATRYAPHLEKCLGLAGRQSTRVANRRMGSQSPFTAVNLSEDSMGGSDIESSSFEKKRRRALGKISNDLSRLKKIRAQGSSSQGDHKVIKFRLVLVFKKTNCTHLRMKADTKETSTDADHIRAELEDSDASESNYRSNGRRSASPGSYAGDVNRSSSVPIKDVPRSPTSDDSFSKSDRRATAKAGSVCSRSKSKLAIYSSDEEDFDPKADFIELSFCMQTLMVPNPRESDQPISALSGCRNLYFFSHFTPKMHMKLKPSLEEVQELVNSGAGNTIPIYAELHADMLTPVSAYLKVSDRSKYSFLLESVAGGETVGRYSFIGSDPYKVIKVGQNEQVKGDPLNVVENELKDIKYVTVPGLPSFTGGAVGYIGFECFQHFEPTLKRDLTDPIGIPEAIFVLCDTLVVFDRVRQVVNVVSHFRSNVTDPEDVKREYMKAAEEIECTLTLLNDPHTPEIPQPPIKLGYKATSNVGKDGYEGFVTNLKHHIKEGDIFQAVPSQRLSRPTSLNPFNVYRHLRSINPSPYMFYVNLDGFQIVGASPEMLTKVENRTVYTHPIAGTRKRGKNYEEDKALAEDLLADPKERAEHVMLVDLGRNDVNHVCKPETVKVDKLMEIEMYSHVMHIVSNVSGKLRDDKTPYDAFRAIFPAGTVSGAPKIRAVDLIMGLEKEKRGVYAGSVGHFDYSGNLDTCIAIRTMVFKDGIAYLQAGGGIVYDSVEEDEYHETMNKMGSNLTAIAECELKHYEAQQEELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q350</accession>
    <name>A0A8H7Q350_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Importin-95</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Karyopherin-95</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_000956</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the importin beta family. Importin beta-1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q350"/>
    <dbReference type="OrthoDB" id="10263328at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000027">
        <property type="entry name" value="Importin subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="11">
        <location>
            <begin position="34"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00079884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2185043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="871" mass="95644" checksum="02DF9C2263D03CCC" modified="2022-01-19" version="1">MNVATLLSNTLSPGTLVNILFILNRVDQATREDATQKLELAAQENYSAYAVMLSQELANEQADPNIRTAAGLAEASRKEDYVNRWLTVDENTRSQIKQWTLSTLASSNSRAAHTAAQVVAAIADIELPVQQWPQLIQILLDNVTTSDNVLLKQASLVSIGFVCETTNPEVLKSQANDILTAVVQGARKEEENQEVRLAAVRALYNSLEFIRENFESEDERNFIMMTVCEATQSSEEQLQVAAYECLVRIMQLYYDNMLLYMEKALFALTVVGMNNEESGVALQAIEFWSTVCDEEIELQLHAEEAAELGEAPQRVSHQFARAALPQILPVLLFLLTKQEEDEDEDEWNVSMAAATCLNLFAQCVGDDIVPPIVPFVESNISNGDWRYREAAVMAFGSILDGPNPVLLTPLVDQALPLLIQMMKDPVVNVKDTVAWTLGRVSDFLPQCIKSDVHLQDLVTALVYGLQDSPRIVANCCWSLMNLAEHLGGGDDLNTPTCALSMYFEGIVGALLQFTERQDNEANCRTSAYEALSTLVGNAAMDCLTSVQQVVVTILDRLEGTVSVQNQIIGVDESNAHAELQSNLLSCLTSCIRKLGSGVSEVADRIMTILLGMLTTSSKQSSITEDVFLAVGSLTTALDTDFARYVEPFAPHLYTALQHPDEHQLCAIAIGLIGDICRALGEGSLPYCQTFMQLLVTNLQSPVLHSDVKPAILSCFGDIALAIGAEFEPFLDVVMLALQQVGGMRAEKDNWELMDYVVRLHEGSVEAYVGIVQGLGSGRKTHLLAPHVGSIFAFLGMVTTEDTLNEPLVRSTVGLVGDLADAFPGGELKQYLSADWVMQLIKEARSNRHYSDSTREVARWAKEMVKRATSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3R2</accession>
    <name>A0A8H7Q3R2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3R2"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF263">
        <property type="entry name" value="PLECKSTRIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="512"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2184753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="705" mass="80253" checksum="EDD6EEFE5A0A7A21" modified="2022-01-19" version="1">MATTTIVSETGLSRHQLPTTKVHYYNSTSDSSALKKPAITSAEFDYSGSSSSVVSITNPYSTREPLSHNMSCNLVESQWLESKHKNSNAITPSASVSKFTYLPSGPETERVRRDMSIPQSLSDSSLSARTNAEGSEHAQWARDCIARLLSENKSLEFAPNIMQKDKKTLDTNQIRRSTSENMLIPENKRSNGNMLRQPSRRIDRARSFKQPGVGTISEENTGSSQKDNTQLKPQEPSRIIRRLSFLAQPLKRSLSLISDRGGSMESINTAQENERRALPKKDRKMDALQQTPRSARPMSMAVPSTSTSLLEQPPKRNLAHRMSSIELMQYLSSNLLNVEQDLHHDRLEHFRSTNSSNVTTLDDNTSSTTSDAESPDTVLSGIEFPIAAFPETKGDRHSKTEARPRKRSLRKSISNIDLLALGKVFKSNTLTEEQIMRSSSYGGKSNTKTVSKREMRSIITWKNTVQQLKSEEAVQLLPPLSYQETMLCLTLCVWQLFMCIQSEAQRIRNEQIRRFIIQEIYTTEQTYLDHLNIIKTMFMDPFIAAATQTTRPLINPQDISTIFAYIPNIIEISNILAYRLESVVRTWHEQQSVIGAIFLQMESDFEVYIRYAVNFHQSQRCINRAHNNILYRRFIQESLRKKETNRMGLTDYMIIPIQRVTRYSLLLKDLKKHTPTTHPDYNNIDKALKVMTGLALAMNDAQKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4B9</accession>
    <name>A0A8H7Q4B9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4B9"/>
    <dbReference type="OrthoDB" id="642895at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="894"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2185070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1062" mass="123580" checksum="8845BA4F203D3A29" modified="2022-01-19" version="1">MGSRDIDERLLLRWATPEDLDKTSKAVVDVFSSPSLRLESLGIQFQRLSAGENGLMTNKDCLVIVDKKDPTQPIVAFTSYWQEQHIYEGISYNVGRPAWVGVKDNPDFRGKRLQQHILDELHRRSKEDGTLVQVVNGINYYYRQFGYEYAIEYGQRSKTWLQSIPTLKDGQVETLRYRRATMDDVDDILAFDIARNQNCAVFLPMSRAWITAQLKEFEKKREDATYFLTRQVIMFENFDGKTVGFFIIWGLEDEACGDIMSVYHMGFAPDLDIASVIFSAMRNVIAFIKTQVDETRFAQFTSIGWHMSESHPVARAIPSHMRIPATMPYDEDFAYYVRVPELDAFIRHILPALNRRLKESSLHSSYTGSIRVSNYSPKVPGFELDIKNGEICQVSRFVKRDQRYDPNLARFPSHTFLLVLFGRRSIDDLKYIFPDVDMSEDVQKILDVLFPKKISIIHHYMYPCLDWSTARDESALKFGEDAPDSLCEKISVLYEEIGTSEKDRKEQTQSLFESFIQLMDQQTKTITEERESLKRKCTDTLDNIARYKRLMGTYVDNEVISTPKHPLLTWLSELCDTEEIYQRLCHSELHKRVDAFRYTLGDFVECERLAEEDIDVSQPAISHIEDGLNKYQAEYDSRCKEVMEINRQIQEHWNTLGITAKDDIEVALRDLWSAKDDDEEQDTLLMRLVSPSHFEQITQKLEMLMEFRSQREFCVDELLHKIMKIWDLLCLESELQRLNVIKEERMEEFIRRAREELKSLWDQLYYSDEQRQKFKPAYTESTADETLEAHEKEITRTHILIEDQKHILERVEKHMRLVEEVKQFEASMSDPNRLFGKGQRDPGRLLREEKFRRRIAREMPKVKRELRSALKEYQETNGKPFCVFGKPYTDLMDEQEEQEQAKTAKTNRTLKRSSSEMAAASTPRRGNDKRIAKTPSTTPRTKPKALVLTPHRHSALAAAGEGTTPSNRRKRIKNHFEEAGLNDAEDSILHKVREHNLTSNRKTALQPLSDNQLPTKSTKEFDTIKGVDRAGSPTPTTKIMWSDEDIDEGIFDDGPDLSDLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q585</accession>
    <name>A0A8H7Q585_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_002635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q585"/>
    <dbReference type="OrthoDB" id="73348at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1050.10">
        <property type="entry name" value="At2g23090-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045230">
        <property type="entry name" value="MBS1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026939">
        <property type="entry name" value="ZNF706/At2g23090_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21213">
        <property type="entry name" value="GEO09665P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21213:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118359">
        <property type="entry name" value="Expressed protein At2g23090/F21P24.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2186197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="61" mass="6663" checksum="19B286BBA6C2088C" modified="2022-01-19" version="1" fragment="single">ARAAKEADKHKGGKSQLGARAAGLQFKCPKCMTPMANYNLIVQHMEAKHPKDPVPTIESFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5A8</accession>
    <name>A0A8H7Q5A8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_002591</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5A8"/>
    <dbReference type="OrthoDB" id="27537at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="146"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="315"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2186153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="388" mass="43456" checksum="21D135D49928C5A4" modified="2022-01-19" version="1">MFFFSSGDCIGVENPLLQYVTGKTQLCLRRVMQTQQDDASPPPLALSLSLLSTFKPAKVFKDNTRPISSISFDNTGELCVSSSSDESIHVYDCRQGKLQATLYSKKYGVHLARFTHRSSNVIYASTKEDDTLRYLSLHDNKYIRYFRGHKKKVTAIEMSPLDDLFLSASMDETVRFWDLRSSSCQVRLPIFYRMNVIDVDDECLQGLLNTSGTPTVAFDPSGLTFAVGLNSETIKMYDVKTFDKGPFATWNLADSQTAHGFFSWTSLKFTNDGKHILVTTSGNTHYLVDAFEGNIKQRFEGHIGLQTPDNGGCDVGLTPDGRFVFAGSQDGNLCLWDIENPNVDNKPIKVTRTEHTPLTCLGFNPKYTMMVTGNEELAIWQPDITMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5F5</accession>
    <name>A0A8H7Q5F5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="9">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_002328</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="9"/>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5F5"/>
    <dbReference type="OrthoDB" id="422663at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17949">
        <property type="entry name" value="DEADc_DDX31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="190"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="514"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="528"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="748"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2185890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="809" mass="89344" checksum="9F9776DADA19F089" modified="2022-01-19" version="1">MDDDGLMLNFGGPSDSGSVQERRTVAKGGKWRDRLKAKKAANTFNRNNNPLLAPRIPSTNSSAMNKGVPKQRNEKMIQKNSEVVAGAGDDASKPAPTGPKLKHGKAQVMSSLFTSNPTIERNYKQEKTHVPENIIPSNAPVADTTSFIGIGLDSDLVDHMKTKLSIAIPTNIQKKALPILLGPSRTVLDAEIPKKDVDVVVQAETGSGKTLTYLLPVVNRLIAASTSDGSSKIPAFGDRAIGTVAIILTPTRELAQQVLTVLTTILSIPPSKTPGKKRSHWIVPGIVIGGDKKSSEKARLRKGVNILVSTPGRLLDHLQNTKSFNVQNLKWLVLDEADRLLDLGFEETLKSIMKIVDERTGLGVAEKFKGRVSNKYWPKRRQTVLCSATLRDDVQKLAGQSLIDPMFISGHGQVSTMATATEDGALAAREEETKFSTPNQLKQTCVLTPAKLRLVTLLAMLKSCYTVHKGSRVIKQKNKVIVFFSCCDSVDFHYDLFIHAGKQKEQHENEDDEDLTQKVLRQVLSNEQHHKKNFKRDTPPKPAAESQKDETVGVSGIGKVLENVPIFRLHGDLAQSVRTQTYHEFGQAESGILLCTDVAARGLDLPDVNRIIQYDAPSDLKDYVHRVGRTARLGKAGEASLFLLPSEMDYLDILKAQDLHASIIPVENVLSNLITYANSQDFQTPAQELQNLLEQCVLASSERMNLARKSYWSSVRAYATHSAAEKHIFHIKKLHLGHYAKSFAMREAPSDMNEGGSKTQKKRKQKNDRLPGMNKKSNRTRNKYDQADEFAIASSGYQLAGPRTKRKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5Y7</accession>
    <name>A0A8H7Q5Y7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UBX domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_002854</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5Y7"/>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14348">
        <property type="entry name" value="UBA_p47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01770">
        <property type="entry name" value="UBX_UBXN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000179">
        <property type="entry name" value="Plant UBX domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.210:FF:000002">
        <property type="entry name" value="UBX domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF20">
        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SEP" evidence="4">
        <location>
            <begin position="195"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="3">
        <location>
            <begin position="307"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2186416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="41381" checksum="55690525BDC390D0" modified="2022-01-19" version="1">MADHDQLIAQLMSMADISKDKAQFYLEMSQWDLNAAASQYFETGGEEDPAIDAPLSSDPLASGSAGVTTGPSTSSSSQAKSKRVATLRDFSSDDAEKDDEPQSFFAGGEKSGMLVEAPRKDGQDKRNLVEDILKKAAESGAPQGEEEEPERPRYFAGSGTCSMERKGYKLGSEEEPSVQVTAESGSSDEPVSSVPVTRQLTFWRNGFSIGEGPLLRYDDPANEFALNAINSGRAPLSLLDVRPGQAVDVRVAKRLDEDYTPPPKAPPKPFEGAGHRLGSPSPEVRSSSSSPAPQAQAPRASQLNVDTTQPVTALQIRLSDGTRLVSKFNHTHTIADVRGFINASRPGEANRAYVLRSSFPPKPLTDESLTLADAGLLNSVIVQTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q719</accession>
    <name>A0A8H7Q719_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_002871</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q719"/>
    <dbReference type="OrthoDB" id="2446884at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="46"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2186433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="24732" checksum="55E69E852F239AF0" modified="2022-01-19" version="1">MLSYQYAPAVAAVLVAYARADVLDDTLNGLAGLDASPFAGPDDSGDPTTTTTYDSGQYTWTPSSTTTDSSTDTSTDTDTSTTDTSTDTSTTDSSTDTSTTDSTSTTDSYTSSSMPTDSSTISSSYSSPITSSSMPTSTWMPSTTSTSFLPSSNSVSSSISALPTDSTGGGSGGLSTQQKSIIGGVIGGVGGAALLGAAAFFLMKRRKRNDGEFEVYQPEHDYEDESFPPQHGRPYSDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U724</accession>
    <name>A0A8H7U724_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_000201</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U724"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000006">
        <property type="entry name" value="Aldo-keto reductase family 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="41"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2172851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="328" mass="36533" checksum="AAC258B45EE7FC31" modified="2022-01-19" version="1">MSLGRTAKLNTGAEIPLVGLGMLISYAYHVLSCMLTWFSIGTWLAKDNEVKNATVHAINHGYRHVDCAHVYRNEHEVGDALKNIKTPREQVFITSKLWNNSHRPEKVEKALDVTLKDLGVSYLDLYLIHWPVAFKPTDDLFPLSEDGKTALDDGVTIEETWAAMEKLLDTGKVKAIGVSNFTIPKLEKLLKTAKVVPAVNQVELHPYLPQNELLDWCKEHNIHLTAYSPLGNNLAGATRVVEDPTVVKIAEKNGKTPAQVLISWAAQRGTSVIPKSVTPSRIESNFHDFELSKEDFDAINALGSKKVRYNVPSRYDPAWPVDVFGDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7I3</accession>
    <name>A0A8H7U7I3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_008271</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7I3"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="8">
        <location>
            <begin position="4"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="487"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="506"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2171545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="609" mass="68508" checksum="19E9FCD3F37D1208" modified="2022-01-19" version="1" fragment="single">AQTALYDVQGGYRAVLFDRIQGVKPVSAGEGTHFLIPWLQKAVQFDVRTKPRNISTTTGSKDMQMVTLTLRVLHRPEIAQLPTIYQNLGTDYDERVLPSIGNEVLKSIVAQFDASELITQREIVSSRIREDLVKRAREFNIELEDVSITHMTFGKEFTNAVEQKQIAQQEAERAKFVVEKAEQEKQAAIIRAEGDSQAAELISAALEKAGEGLVEFRRIEASKDIATTLAQARNVTYLPSSSNGGGSNMLLNVGVEMDNKACSRQGNAATGTWRVLAGVDRRICQHWHVINVTDSGAVTVNLLWDQREVASNQSTFCATMMSHCQATNRKVHLVNLDPAAENFEYEPTIATGNGFAFSDIRDLITLEDVMEELDYGPNGGLIYCLEFLLNNMDWLEEELGDYEDDYLIFDCPGQIELYTHFPIMRRICEALQRWNFAVCGVYCLESQFIEDKSKYFSGVLSAMSAMINMEIPHINVMTKMDLVEGDYGNQPATADEDDGGGNNKDGRKKQAKRSARSKTKKELERYFDPDPLLLIEDVNNSTSSRFHALNQSIVQLIEDYNMVSFIPLNIRDDDSINYVLSNIDNAIQYGEDIEPKEPDDMVEYDDNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7R4</accession>
    <name>A0A8H7U7R4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_001472</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7R4"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2171995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="51699" checksum="549326AEFE5193A1" modified="2022-01-19" version="1">MAVVEADYIKVLMDCLVAEGNIDFKAQVSWALSNIAGESASLRERLLHQNAMSAVIQVLRTLYDQIAQVSAADSINPIAVIREKGAHADVRVLTWTVSNMCRGGFKTKELWQLYIPAFEVLSDMTLLDDVEICTDACWGLSRILSNMHKVEPFLKNLKIHNDLCPRLVRLLASDNVLLQTPVLRTVINIASGPNEHISCLLRGNPLETLLRYLSPSVLPHFRRDALLTIANIAAGNETHVKQVLSTDGIMEMVETYLRIPDTDTAVLPYASKSTYNNEDIEEEWKITQEAVWIICNVTSLGSIESVCAMLDAHPQIPNRLSRILQYQSAPMPTLLKVLDAMINILSRTSELYNVTPPISNRPTNPYYEEFAQHGVMTRIKMMKQEFPGVHALQERLDLYASAANNCAHNIPSYTLVSGSADAFGLPSRKVLTTGANTRRVVRGTEDGDVRWVEDAVGKLCILEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U807</accession>
    <name>A0A8H7U807_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_002959</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U807"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732:SF2">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034980312" evidence="4">
        <location>
            <begin position="20"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="6">
        <location>
            <begin position="85"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="5">
        <location>
            <begin position="225"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2171337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="607" mass="68474" checksum="24CF8E76BE8C1458" modified="2022-01-19" version="1">MKISIVLATALFYASVAEAFKTKTPPLSTKWTKEAAEADVPWPSYPRPQLQRQDWVNLNGVWEFQNSTKGALTDMPFGKTLSDEIKVPYCMESGLSGVMKHYDYSVYKKSFTVPSDWKDQSVLVNFQAVDNEATVFVNGKKVGYNKGGYNRFQVDITDALKNGKNELMVHVFDPTDSNGNNPPLGKQRSQPSHIFYTPCSGIWQSVFLEPVPKQYISRLDVLTDMHGNMNVTAISNKATAAQVVMVEVLDKHNKTLISKAGHANKSFMIKVPGVKTWSPDQPNLYNYKVTMGKDVVNSYTGFRTISRGVVDGVERPLLNGEFIFQFGTLDQGFWPDGIHSPPTEEAMIYDIQFLKKLGFNMLRKHIKVEPDLFYAAADRLGIMLWQDMPAMVEYKAPTDDQQAEFERELATMIDNHKSFTSIVTWIIYNEGWGQLPSGPETYLTPRVKSQDPSRLVNSVTGWNDHGAGDFHDNHHYSIPQCGSPFYSIASTPYDKKRIGVQGEFGGIGQNTSAAHLWPVAEAVNSINQTYEITENNDAYNYRTLQVLEQLREQVERYSCSGAVYTQTTDVEGEVNGLLTYDRKVIRTDVPKWQKMIKDIYKAAKSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U844</accession>
    <name>A0A8H7U844_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U844"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF21">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="47"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2172685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="331" mass="37085" checksum="BBD1BD373DD62B1D" modified="2022-01-19" version="1">MQALAPARLSEFNFQRHLDVPDQGKVTFPLVITPESGLETIDQATHWVQQHQDQLLELAKTHGAVLFRDFPVHSAQDFDAIGNAVGLEEFPYIGGAAPRRVITGSVFTANESPADQLIPYHHELAQSKSHPYHIMFYCDKPADKGGETPICLSHLVYQQIKKEFPDFIEEIAAKGVKYIRVLPAEDDATSAIGRGWQSTFMTKDKEEAERQGRELGMTLEWQADGSLRTTSPILSATKLDERTGKTSWFNSIVAAFTGWQDSRNDASKAVVFGDGSPLDPVILRRCLDVMNEICCSFEWKQGDVILIDNVVTMHSRNSFEGSRRIYASLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8R0</accession>
    <name>A0A8H7U8R0_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8R0"/>
    <dbReference type="OrthoDB" id="2121849at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="410" mass="46741" checksum="3F8B646551B73734" modified="2022-01-19" version="1">MASLLFEDYDFPREMWDSSTRTFTTPVDTLLSFCPHIVTQLKKETQDQEPIKQEKGTFEKIFESSKTNLSGAFSTSLAEKTFRFCMEAATAYLQSSNDRRNRQRYHSVQYGPELDDEEEEEEIRLRELRTRRKEYEKQELARRKKDKKSDSEDQVDGKEIESRALIKRERMSLMTKSLTSIAALTLSLYSAHRASLSWGEITFQSQLELLTTHVKAALESTTAWIKDRKDMNDSVPDVLLRDVTRLQELLSLIERLDSRREKRMETAGWSISAAGSLSVLGGIALGWTDQALSLSGAAMVGGIVFGIISRNRWNGPAWKASKAVLEVRLSSLVREITNDAAIRERTMNQLEQKVRRPNLYYTEDMEDYENTNFVPHGIKVELNDTGTTTAATTTANQNQRNKKQPIGTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9B5</accession>
    <name>A0A8H7U9B5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="17">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">INT43_004571</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 17">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="17"/>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9B5"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16 17" id="KW-0274">FAD</keyword>
    <keyword evidence="5 16 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11 17" id="KW-0520">NAD</keyword>
    <keyword evidence="10 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="19">
        <location>
            <begin position="35"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG2173197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="277" mass="30570" checksum="49E9CAD183A30CE5" modified="2022-01-19" version="1">MDSVQSLLPYIISAGAVAAAAYFFANKKQPALDPKVYKQFKLIQKIVISHNTALYRFGLPNKDDVLGLPIGQHISIMAEINGKQISRSYTPTSLDEDKGHFDLLIKSYPTGNISKYIGEIQVGDSIAVRGPKGTFNYSANLVREFGMIAGGTGITPMLQIIRAVLRNPDDRTKINLIFANVNEDDILLKKEIDELALRHDNFNVHYVLNNAPANWTGGVGFVTPDMIKQYCPAPAKDIKILLCGPPPMITAMTKATTELGYDKPRAVSKLEDQVFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9E9</accession>
    <name>A0A8H7U9E9_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_004661</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9E9"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08283">
        <property type="entry name" value="FDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF1">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034165955" evidence="6">
        <location>
            <begin position="27"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="8">
        <location>
            <begin position="81"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="7">
        <location>
            <begin position="251"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2173287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="461" mass="51278" checksum="2E26598E641B6E6A" modified="2022-01-19" version="1" fragment="single">ATAWTTEISYLFFCLLSNKLITFIMANPASNIAQKHMGEIPVPVANQDKENKGSEDMLACCWVGKDKLEMRRVPKPTITNDEDVILKVTGSTVCGSDLHLYHGEIMQLKEGEILGHECMGIVEAVGPKVTNVKVGDRVVAAFNIACGKCQYCQKKQFTACECTNNSSVMQKLYGERIAGVLGYSHFLGGFSGVQAEYARILFGNTNLVKVPESVPNEKALYLSDIVPTAYHAVWEANVKEGDVVGVWGLGPIGLNVCQWLRNVFKASRIIAVDDVPERMELAKKEWGVECINFDTDTDVSAKIYEMCPDGLDRAIDCAGFRYAKGMVHKVERALGMETDTSEVVNEMIRATKKFGTISLIADYAAYTNHFLIGAVMEKGLRFIGCGQAPIQRHWDQCLTHIQNGEFDPTIILTHRFPLEQCVEVYRRFDRKEAGIMKTYLQTRFSEPQTPGTPTLMNVDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9Q3</accession>
    <name>A0A8H7U9Q3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9Q3"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="157"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="396" mass="45465" checksum="5EF9D7D0646E7F05" modified="2022-01-19" version="1">MEVEHRPKQVKQRPSRLSLSSQNMADLSILSPRTPKSIGKPSSRRQSVAEQFSTISRRSSTASSVIAEFANPPGQPFTPNLLSEAISYFPDDSTSSPPTGRTRSCSLTSLANITGLANSDGHTLYKVKTTKTNRKLNNFFGEQPPLDICVREIRKEGLKALLQSKVPLCYFLYHLLEEFSSENLFFFIEVEQYESFVYQTQTQQLATAQHIYDAYLTRNSHFEVNLDDRVKRSVVTDLEARALDDIFHQAKQAVFGLLDHSFHRFLSSTTWHAMTENCGDLNTYYDEVCRNKAVNFLLQYLERQHDILYTNPHTDQLSASNSSRRRYEVLKSMIHEFCRTLLNVEFNYYKPEPADRDFVLKNNSTPSPPRTSEDRAGSKSPTKKNKERFDIFGRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAE3</accession>
    <name>A0A8H7UAE3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_001257</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAE3"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16650">
        <property type="entry name" value="SP-RING_PIAS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="6">
        <location>
            <begin position="323"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="420"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2175610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="482" mass="54248" checksum="AE6A6DB86DC9EF1F" modified="2022-01-19" version="1">MSSDARPNRVKFRPVPRSITHHHVQLVCSELPHRNPADVRWWLLHPANLVHFNVKELQAISKILSTNGITSIPPSISRKKPKLIGLIISIVFPGYIANESLEKWVQSLDRHYQFVRTVNRASAEKSDKAYRFAYAQLPRTESITDREELMQAKLTGTSEAMTAELALSVLLPILIKGKLKSQMRIFAYIWRYDCRSFDPDDGITLSLGDKVYNLNYTNKNMLRTGHHHIDITDAIDWKAVFAKSDEHLTAGLILQEICHCINQSFAKDKQKTLDLLHQVYSLLQLGSASALDDLVSIKKAYGDTIGLLGGDCLAHSDSSDNANDVDTCQIGDEVISFRDPLTLKRIHIPSKGTHCTHIGAFDLQTFLEFNEWSIEWKCPFCMDNINGLQDLAVSGQFLQLLDKYPHHDRIIRQADGSFCEPLSSSRKRSPEPEPEAYDPNKYRVIDCGDSEGDERASEEPAPIIKPSSNAGTHPTPVVVEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAE7</accession>
    <name>A0A8H7UAE7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAE7"/>
    <dbReference type="OrthoDB" id="10249419at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07262">
        <property type="entry name" value="VOC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006:SF2">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="7"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="132" mass="14393" checksum="9AF99CF5FAAE386B" modified="2022-01-19" version="1">MAKPSSLFNHIALYVKDIHVSRKFYDPVLTELGMELTHDFGEYGYFGYTQKAGGQGAEFGFANGNGKEGKCHVAFNADSKDTVKKYYDNAIAAGGQDNGGPGLRTQYGPSYYAAFVLDPDGNNIEFCYMGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAU1</accession>
    <name>A0A8H7UAU1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_005800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAU1"/>
    <dbReference type="OrthoDB" id="74240at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2174742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="298" mass="33381" checksum="82C2F27D65F6177B" modified="2022-01-19" version="1">MEPSDAKGATQWLFDRGWNCPWVFWEGDFDQNVNLWTDLASLQLAESTCSDQSWLMFKPAPILEESVDWIERSLKSNAKSSESQEMLSCLDIGCGSGRDLAWLLSRKAVDGRPMWRATAVDSSHGATNRTSAICENMGLSGQLDGTLNAKVAVNGLWRLLTRDNSNVQVNNASKKGGKPTAATGESTLEFFSETVQQQISGTIPPKHDLIITIRFLVRSILPHLPSLLNPGGYIIISHFVDHEDYKYDQPRQNHRLGMNELRDLFSSLEGMRVVVDKLEQIEDGRPVNSIIIRKEYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAV0</accession>
    <name>A0A8H7UAV0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sphingomyelin phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_005834</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAV0"/>
    <dbReference type="OrthoDB" id="282973at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045473">
        <property type="entry name" value="ASM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011160">
        <property type="entry name" value="Sphingomy_PDE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF34">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19272">
        <property type="entry name" value="ASMase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000948">
        <property type="entry name" value="Sphingomy_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="11">
        <location>
            <begin position="161"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin phosphodiesterase C-terminal" evidence="12">
        <location>
            <begin position="458"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="55"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="182"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="360"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="593"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2174772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="648" mass="73619" checksum="7B8AF4B0DB5244E0" modified="2022-01-19" version="1" fragment="single">RLLVGNVFVLTTLAADIFQQHSNPVFGDRLETVHEAEVFDAAQNLLSAQSVATSCSSCISLLQVIKNLSYISEGLFISTLIGACKRTGLDPMVCEGVIREQGPVLRHVIRTINVSGRDGHTMCASTLNSCPYPVVEPWNVTFPKAKPKHVRPPTPSGRELTVLHISDWHVDPLYESGTDTVCDKPICCRREFTNYENVTEPASVWGSYSCDTPITLLESMLEYIPTVADKFDFGILTGDVPPHEVWSTLPYNKTQLIVSSSYDLMHIHFDTPGLINTKLYPTIGNHEAAPTNLFPHNLSQIPKDEDKQFLNLTWLYQTLSESWDGWLESETTLQVVHNSGSYVAYPTDGLVLIGLNTMFCYNLNWWNIENGGEKDPNGIFDWLVKHLQRAEDEGKRVWITGHIAPGDNTCLHDYSNYYYQIVERYAPHVIAGQFFGHTHRDELEIFYKKDEKSAANAISTAYIAPSITPFNNMNPGFRLVFEFCQGSRHSTSSDDHLLYSVYKIDAETFDVVDSLTYIADLDKVEEWDEDGPNWHLQYSARDAYSSSRAKLGPKEPLSPAWWHNVTEAFEDNDSMFEKYYQYRSKSSPLRPDCDETCRANLICGIRAGKSEDRCDYQRDDMDQSLFAEYQRNPERYEYNKDLCSGLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UB95</accession>
    <name>A0A8H7UB95_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_002061</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UB95"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15560">
        <property type="entry name" value="PHD2_3_BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="748"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="185"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="447"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="589"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="674"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="993"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="462"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="674"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="689"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2179211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1048" mass="115992" checksum="05B14EF2892FC02B" modified="2022-01-19" version="1">MHGDGILSQIRDLQSVIDDFQIDCQSTGKTSEDMECDTGVNGDKSTDDVYKQKENTDSETKLDGTQIKSSDIFQKPDEVNVEDKEDPTIKEAPSKDPFQKLEFRISSDFSALMDEFTSKEYPLSPVKPRADFNLAKDSYVEKVLIVTDEKTEEEKLSIEKVNQQKAEILKGAMWRRQLHTQPVKRVSKNRIPDSIENQQEHNTLSHISRNSAPQRDNKPSTLTINSNQILKKSKSPMVSTVSSAEAVATINQRGGHSHDPRSFVQMASIDSVQDRISLYDDYFKDCIRAKTGLTAWNNKMQSKPKPAAMLEGYEPPSRNADLTKSIRRSRSSLMVVTSSTSMNALRRSIMKIPKIEPSSGRLSANSSASPNGDSWLDHLATPRIKERATSFLNMRHLAPSRGFSTPNLRSIAGIDFLLFLTSALAFPLKNLAIVMQENDGHARAWQLSSPDNQQEQSKDNPDQSSSTFNISSMLNRESAQPGVNQSKAAHSSPASNQKESNSTLSSPGDQPSQANVPPAYTKTQAAPLTFHQYEPPNAAPVAAEATAKRLPLRKRLTLETKVQQQQQHFARITSPTSADLTTSPLSAGASLTKASVSQQNDLPVDGDTTETDEEKKQVDIAKPIPSQENNDDNQQNAAIMRPLKKAKTWNSRDSTSSQNDFASMQSQFQIIPTTAPAPAPAAASASAPVPVPAPASAPVSTPAPAPAPSSEGIKREMSDDAEILTNKRPKQMFNSPPMSDNKSASSEALYCICRKPYDRPRFMIACDACDQWFHGECVGISERDGALVEKYYCPTCARATGKQMSWKQKCANPACTKPARISNKVVISKYCSGDCGLLLARAKITNCDMKRRAVLEDGKFNATNGPKIRSTADIEDRRLLVNLREQQLELEKSLTHADLRARFLKLVIRRQQEYKSDDVAMEEAKGIKSKRADEGGICGYDSRLSWESDQSWTSCLDESDDDVAVKKLDEGQFKVCLNSRKCQRHAQWQKLKAAEIELERSEDIQAMAKLKKERHQAKLRMKQRRENVSAVVNNGAIDHTLPGAVAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UC28</accession>
    <name>A0A8H7UC28_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA topoisomerase I</fullName>
            <ecNumber evidence="7">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_004436</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="7"/>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UC28"/>
    <dbReference type="OrthoDB" id="47179at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00659">
        <property type="entry name" value="Topo_IB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00660">
        <property type="entry name" value="Topoisomer_IB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.41:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.11.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.15.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018521">
        <property type="entry name" value="TopoIB_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00176">
        <property type="entry name" value="TOPO_IB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="9">
        <location>
            <begin position="312"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="657"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="6">
        <location>
            <position position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2174413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="786" mass="90626" checksum="7B3C99D6B4678F77" modified="2022-01-19" version="1">MSSSSSEDDIPLSKKRRQDKFAESNASMSGRSAERTPDPAMARTKSVINDDDSSDEEMPLAKRASSKTNGKAMKREASSDEDNVPLSKIVKTTKKPTPKKRIVNKEDSSSDDEKPLAKVKKDIKKVAKVKAEEESKVVRKQTKKVKDEEAEAQFKWWEKSNEEEDGDVKWNELEHNGVLFPPAYVPHGVKMKYDGKPISLSPEAEEVASFFAALIETDHGKNPVFQKNFFSDWQEILKKDSSNPNITSFEKCDFRPMYEHFEVEKERKKQLTKAEKQTIKEEKAKVEEPYLYAIVDGRKEKVGNFRIEPPGLFRGRGDHPKTGRLKKRVMPEQVTLNLGENAPIPKPLDGHKWGGVVHIHEATWLASWKENINGSIKYVFLAATSSWKGQSDMQKFEKARDLKKHVNRIRRDYRQQLNDKLMETRQRATAMYLIDVLALRAGNEKGDDEADTVGCCSLRYEHVTLEPPNILVFDFLGKDSIRYHNSVPVDAQVFKNIKIFKKQVGPDNMIFDRLTTMSLNKHLGSYMKGLTAKVFRTYNASHTFQEQLNKLTREEDSIPDKLLSYNRANREVAILCNHQRSVSKNHGQMIAKIQDKIRALKYQRKRLRKQIVQLDPKMKKSKLTEMEEESDLEDEWIAEHQKDLLVKEREKITTRFEKNNEKLASEGKPPQPKEELKEKLKAVDDWEKELQKEKKTGKIEVKASATVEKLLAQITKLDERIKATKTQALDKEEGKETALGTSKLNYIDPRISAVWCKKYNVPVEKVFSKTLRDKFQWAMEIDADWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UC73</accession>
    <name>A0A8H7UC73_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_005431</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UC73"/>
    <dbReference type="OrthoDB" id="4217619at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06786">
        <property type="entry name" value="cpPDZ1_ScNma111-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06719">
        <property type="entry name" value="PDZ2-4_Nma111p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025926">
        <property type="entry name" value="PDZ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46366">
        <property type="entry name" value="PRO-APOPTOTIC SERINE PROTEASE NMA111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46366:SF8">
        <property type="entry name" value="PRO-APOPTOTIC SERINE PROTEASE NMA111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12812">
        <property type="entry name" value="PDZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="305"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="783"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="885"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2176197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="994" mass="109421" checksum="D8254D28702DEBA7" modified="2022-01-19" version="1">MQPESSSGQSTPETLDMTGSNTAPPVKRRRISSSWSQPGKNSADQAADSTSNQVDLEMTDAPVNGSASASIMHPPQWQDTIEEAVKSIVSIRASQASAFDTEPAESSEASGFVVDAARGIILTNRHVACAGPFVGEAIFHDHEEVDVFPIYRDPVHDFGFLKFDPKKVKYMRVKQIALKPEGAKVGIDIRVVGNDAGEKLSILAGSISRLDRNCPDYGDLTYNDFNTFYLQAASSTSGGSSGSPVININGDAVGLQAGGHTKAATDYFLPLDRVKRALHYIQQGLPVPRGDVQAHFMYRPFDEVLRLGLQTSTEAKIRKLFPEEIGMLVAETIVPKGPASKFMEEGDVLLTINGEYITKFGPFESVLDSNVNKDVVIGIERGGEYKEFTLNVGDLHAITPDRYVEIGGAKLNELSYQLARSYCVPCQGVYVCEPHGMFRLDGADQGWIIKSVDDKETPDLDTFVEVMKGIPDYERVPVVYHSIADFHTTLVAVVQVERHWAPFRMAVRNDHTGLWDFTDFGDPIPPKVIEPTTAKFITMNDSLGPAKELIRCLVKISYYMPCRLDGFPKSRKFGAGLIVDKDQGLIVVSRSVVPTLLGDLSITFADSVIIPGKVEYLHPTHNFAIVRYDPKHIGETNVLEAPLSDDKLGQGHKVTLVAYNHNQRPICLTTTVTDVTCITIPHNASPRFRGINMDSITLDTPLAQQCSSGLLADAEGKVQGLWLSYLGERNMNGHDSEYHLGLDISAILPCLRPLQQGAKPKLRSLNIELMPVQIAQAVSMGLSNEWISKVEKSNNTKHQLFLVRRMEAGSASAQVLKELDLVLAINGETITRMSQLDVQYDAEVLNMTILRQKKEITLDVPTSDIGEDGGATKRVVFWAGSALHEPHKAVLQQSKSLPSKIYVSARAKGSPAYQYGLVPTTWITHVNSKPTPDLDAFLEAVRQVEDNTYVRIRTVSFDNVPIVVSVKTNNHYFPTSDLRRDESSLCGWARREIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCB0</accession>
    <name>A0A8H7UCB0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-conjugating enzyme UBC9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2-18 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_004332</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCB0"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019787">
        <property type="term" value="F:ubiquitin-like protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000035">
        <property type="entry name" value="SUMO-conjugating enzyme ubc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="13">
        <location>
            <begin position="5"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2174309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="158" mass="18110" checksum="EFB793CD26CA1BBD" modified="2022-01-19" version="1">MSTGIARARLGEERKQWRKDHPHGFWARPGKNEDGTLDLMNWSCGIPGKAGTMWENAVYKLVMIFPEDYPSKPPKCKFTPPLFHPNVYPSGTVCLSILNEEEAWKPAITIKQILLGIQDLLDDPNPESPAQSEAYLLFRKDRPQYEKRVRLQAQQNMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCF0</accession>
    <name>A0A8H7UCF0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal protein L14e domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_005835</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCF0"/>
    <dbReference type="OrthoDB" id="1875589at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="4">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein eL14" evidence="5">
        <location>
            <begin position="48"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2174773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15283" checksum="570B3279DD3938EE" modified="2022-01-19" version="1">MSGSFQRQVEVGRVVLINYGADAGKLAVIVDILDHSRALIDGPTTGVKRQAHAYRRMTLTPLVVKDLPRGAGATAVKKYLEKNETIAAWNKTAWAQKLANRVQRKNLSDFDRFKLMKLKSQRRAIVGPATAALKKQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCI6</accession>
    <name>A0A8H7UCI6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cell division control protein 42 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_003167</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Lipid-anchor</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCI6"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000236">
        <property type="entry name" value="Cell division control protein 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2177920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21374" checksum="EB20E1E7712B99A5" modified="2022-01-19" version="1">MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGEEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVTSPASFENVKEKWFPEVHHHCPGVPCLIVGTQVDLRDDPTVLEKLNRQKQRPITFDAGERLARELGAVKYVECSALTQRGLKNVFDEAIVAALEPPVRKKSKRCNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCL2</accession>
    <name>A0A8H7UCL2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCL2"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="59" mass="6663" checksum="65A32EEEEB68BA43" modified="2022-01-19" version="1">MQRKSLWGSYKGIPPRTRIYLGLGGMAFAALGIFISDKFEETYPVQQRTESVPVVIDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UD15</accession>
    <name>A0A8H7UD15_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_001080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UD15"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000040">
        <property type="entry name" value="Putative tatD related deoxyribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2175433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="314" mass="35832" checksum="A4833507AAD2AFC2" modified="2022-01-19" version="1">MSAAKIRLIDIGINLTDAMFRGMYRGKRGHADDFDLVLERARKAGVERMMITGGSLSESKEALELAETDEHLYTTVGCHPTRCQEFQKHKGGPDQYYEDLKKLIKEHSLSHKVVAIGECGLDYDRTHFCPIEVQKKYFLRQFDLAEETGLPMFLHSRNTGSDFNDMIRANRTRFKGGVVHSFTGTMQEMTDLIELGLYIGINGCSLKTEENIEVVKAIPEDKLMLETDGPWCEIRPTHASFKYWKNVDEGTQTLYVPPSKKKEKFERGFMVKSRNEPCAMGQVLYVVAAIRGLEPQELAEKVWKNTCQVFFPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UD27</accession>
    <name>A0A8H7UD27_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_008728</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the GSE complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UD27"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000002">
        <property type="entry name" value="Ras-related GTP-binding protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000488">
        <property type="entry name" value="Small monomeric GTPase (Gtr1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2181146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="299" mass="34267" checksum="B926FBD68361F99F" modified="2022-01-19" version="1">MKKKVLLMGKSGSGKTSMRSIIFSNYIARDTRRLGATIDVESSSVKFLGNLTLNLWDCGGQEAFMENYFASQRSHIFNSVELLIYVFDVESRDSEKDIHYYQWCLEAILEKSPNAKIFCLLHKMDLIPLDQRDQLFAHWKNELQTLSLPLEPVVFPTSIWDETLYAAWSKIVHCLIPNIDTLQMHLDSFCEICDADEVVLFERTTILVIANAARVEHPDIHRFEKISSIIKQFNPSGREPSHFKSMEIRSGTFSAFIDVLTNNTYVMVVLSDSTIQSAATLHNINVARKHFKLLEIDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UE64</accession>
    <name>A0A8H7UE64_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="3 14">2.7.7.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">tRNA-histidine guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">INT43_007306</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54564"/>
            <dbReference type="Rhea" id="RHEA-COMP:14193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14917"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:141847"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.7.79"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="16">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="3 14"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UE64"/>
    <dbReference type="OrthoDB" id="62560at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3000:FF:000001">
        <property type="entry name" value="tRNA(His) guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028980">
        <property type="entry name" value="tRNAHis_guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="17">
        <location>
            <begin position="6"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1 C-terminal" evidence="18">
        <location>
            <begin position="139"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR028980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG2182376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="265" mass="30457" checksum="380084F8268AC3DB" modified="2022-01-19" version="1">MANSKYEYVRNFELDDSALPSTWMVVRIDGRGFHGFSDMHTFDKPNDLKALGVMNKAAIEVMKNIRDITIAYGQSDEYSFVLPPSCNLYSRRISKIISTVVSLFASNYAMHWSEYFPDRKLLVAPCFDARLVCYPTKKVLRDYLSWRQADCHINNLYNTAFWAIVHSGKSEQEAEEKLRGTFSKDKNEILFSEFNINYNSLAPVYRKGSVIIRKETEVKSISAQTGKEVSRQKRVPTVLHDDIIGDKFWEEHPELLASNTEVASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEG5</accession>
    <name>A0A8H7UEG5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Biogenesis of lysosome-related organelles complex 1 subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_005664</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLOC1S2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEG5"/>
    <dbReference type="OrthoDB" id="244061at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019269">
        <property type="entry name" value="BLOC1_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46479">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46479:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10046">
        <property type="entry name" value="BLOC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034996483" description="Biogenesis of lysosome-related organelles complex 1 subunit 2" evidence="3">
        <location>
            <begin position="20"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2176424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="19343" checksum="A4B5A84D96E8CE6E" modified="2022-01-19" version="1" fragment="single">TKLNALWAVAGLFFALSQATLPISALMDQPKPSSSQSAPLPRASTKSDFDPDRATASLGQEHVQRLSNNLFRKLTEYTKGELIASSENYKLLETMNNVTKEKYAEMSEMAQRLVKDMSKLQSTYADFSEYMKQIDDISEQADHMEKLCLELDDYTKYLEQKLRNANRTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFM7</accession>
    <name>A0A8H7UFM7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_008848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFM7"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2181265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33408" checksum="47CFE9BDA273A57E" modified="2022-01-19" version="1">MGGRERKLTVDIIHILIHYLSDHETLLALALACDIATTPVAQHIWRCPKPKSIQHVEKLTQVVQQSLSSNAKKQGSRLLPFYRLWITGYDFSTLGPDSALHVPASSFTTLLTITTLRLEYLNLNHCIALSSDLVSRHMPSLRYLNLSSCTQFSSATLISILTQDLDSSLRTLDLSNCSINDAVIIRVARHHNRLRDLYLKHSGNISDSAIMALAESCPELEHIIIGLPHGIVQSNKITDTSMTTLAQSCPRLKTVICRGQTRITEKSKEMFDQKCPNIAICDLSAEEMSSHHQHIQTHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFS2</accession>
    <name>A0A8H7UFS2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_008983</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFS2"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000778">
        <property type="entry name" value="Cyt_b245_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF69">
        <property type="entry name" value="FERRIC REDUCTION OXIDASE 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034024700" description="FAD-binding FR-type domain-containing protein" evidence="9">
        <location>
            <begin position="25"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="10">
        <location>
            <begin position="133"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2181400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="450" mass="50358" checksum="159B9B11BC90BF37" modified="2022-01-19" version="1">MALANIGVALLLITRNSILKLVSGKSFDELLPLHRWHGLLGLGEICFHAAVQIKVAMEEMTPGSTSLPKDQEHISGFTAFIGLLIVFMSSMEVIRRNSFPLFYLSHITGVLLFIGAGFAHQYSVIVLISPPLFFYFIDRVTRSIRSWGVKTQTVAVTVANQQDITKVVFTKGDVPHKVHPGQFVFLSVNDGTFASKFGNFFDWHPFTISEVLSSKQSECVEQKQVDTAERTRSMDLERSVSIPVEQQANNEPLRASIYMKQQGRFTNKIHSQVMKSEKMLHVNVDGPYGSSNLALERHDVVAFFEAGIGITPSLTMLRDLAEKCTTDPLSVQTTHIYFVWVTTNMNSANVFLPQLMESLKIASSAVSPPHIEFDIYLTRCSAETSYIPPFENMKISFGRPVVQDIISAIDTKHSQSSIALQTCGPNLFMRQAANVANRKGWIVRRETFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFU9</accession>
    <name>A0A8H7UFU9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_003900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFU9"/>
    <dbReference type="OrthoDB" id="1727351at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_eS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_eS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2180112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18692" checksum="64098D3F861B8CB5" modified="2022-01-19" version="1">MDDLHDIDNFQGRVRTKTVKKASRVLIEKYYPRLTLDFQTNKKICDEVAIIASKRLRNKIAGFTTHLMKRISRGPVRGISFKLQEEERERKDNYVPEFSALDTSVIEIDPETKELLKSLNFENLPGVQVSAPVVANAQSDFRRPRRDQRPRQARAAPAAEAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGD0</accession>
    <name>A0A8H7UGD0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_006971</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGD0"/>
    <dbReference type="OrthoDB" id="421009at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021538">
        <property type="entry name" value="Syntaxin-5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11416">
        <property type="entry name" value="Syntaxin-5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="259"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="283"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2182045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="350" mass="39955" checksum="91FB140AFEA80892" modified="2022-01-19" version="1" fragment="single">NSLYIDSYSLLSCDDEYILMTFRDRTSEFEALVERLQQRHDGSALERRSLLNNSSVVAHDKVKNKTEFSVIAAEIGRNIAITSAKLEKLTKLAKRKTLFDDKPVEISELTYIIKQDIAKLNKQIAMLQTYTKEQKNGSKQVTEHSSNVVVSLQSKLATTSMSFKDVLEIRTENMKSSKDRRDQFLLSTSEHPTKSNCKSTYVQDDSPLFEPPSKPKSPTNFNAPAVLPTEHEDTLSLGIPMITAQQQQEQQQALMLEQDRYIEHRSSAIESIESTIAELGGIFQQLATMVAEQRETVQRIEQNTEDIESNIIGANNQLLKYYKSVSSNRWLMMKIFATIIFFFMIFTLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGT0</accession>
    <name>A0A8H7UGT0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGT0"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="85"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2181117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="548" mass="61181" checksum="78DB3B7A4E190EFD" modified="2022-01-19" version="1">MPANNLPTPTSYHQLFAYRGLTVPDSPWFHYPEPVTADKYRVLTYKGADDLISHLAAQYADVLPERNEHTISSNAPKSLPEAPMVVATLGSNNVQLALTGLAAQRLQHAYIHVSPLNSDTGIVTLLKTVDARVLLADDVFYERAEKLAAQIEGLQLHRMISFDPVDELKKDLRTFAYDINKDESKNSGLIFHTSGTSSSAPKPIWHANASFMHIPPMGVLRTTLTTGLMYHGMGGGIVLMAANISGSVALPLAKDPNYRTIPEVINSLKALPQIDVIVLHPILIEAFWENYGRNNSPEMEYLKRIGRIETGGGKLAHSVAHAMRSAGVNVRTLIGATEVGPFPLRNEPTEENWDSFVVTNEDQAVWEHIEGDQYELLLQSPPALALNLGIPPDGIYRTNDVFEEIPAGSKQYVYVGRRDQMLIHTMGLNTNPVSWENEFRPLDIVEECQLVGHGRRGPLLLVELNWSLVKNEQEARERVWKEIERINDTVMAWSRVQNREAMVILPRGAKLERSDKETVKRGVNLKKFENEIEQGYANWDKAAPLAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGV0</accession>
    <name>A0A8H7UGV0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Catalase</fullName>
            <ecNumber evidence="11">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_008774</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 12">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="11"/>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGV0"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF9">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="14">
        <location>
            <begin position="10"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2181192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="492" mass="55372" checksum="6B2045CB1ED2C2FD" modified="2022-01-19" version="1">MSPPNADTLTTSNGTPVTDNASSLTVGANGPVLLQDFHLIDKLAHFDRERIPERVVHAKGAGAHGYLEVTHDISHLTTAKFLNGIGKKTPAFVRFSTVGGEMGSADTARDPRGFAVKFYTEEGNCDFVMNNTPVFFIRDSIKFPDFIHTQKRDPRTNLKDPNVFWDFLANNPESIHQVTILFSDRGTPASYRKMDGFYGHTLKLVDSEGKFKYVKFHFTTEQGKENLTVEEAGKLAGENPDFLTQDLFDHIEKGEYPAWKVSIQVMEPEDKDKMPFDIFDITKVWSKKQYPLHPVARFVLNKNPDNYFCEVEQSAFSPSHIVPGIDVTPDKMLQGRLFSYPDTHRHRLGPNYLQLPINRPVVPVVNHQRGGFMAFNNPGGRPNYPDSNLEDAPPKSLEQNNPKKVVTHGAEKVYGITGNYPAPIKEDIDFYQAGELWKLLSDKDKDHLVHNIAGHLGSCKESIRSLQIKHFKRAHPDYGSRVEEAIAKANSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UH45</accession>
    <name>A0A8H7UH45_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit K</fullName>
            <shortName evidence="4">eIF3k</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">eIF-3 p25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_001823</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit K family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UH45"/>
    <dbReference type="OrthoDB" id="337745at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.250:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.250">
        <property type="entry name" value="ARM repeat, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03010">
        <property type="entry name" value="eIF3k"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009374">
        <property type="entry name" value="eIF3k"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016020">
        <property type="entry name" value="Transl_init_fac_sub12_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="43"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2178974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="223" mass="25588" checksum="A6463D136965B9B7" modified="2022-01-19" version="1">MANLAMNRPEVIQSLIDGVDRYNPDNISILEEYLTTQCQNEEYDLMANLAALKLYQFNPHLTNDKVIINILVKALTAVPAPDFNLCLYLLTEPMIIDEPIQQLTSLQQLLEQSRFAKFWETFNSDPSYEKLVSNVSGFKKAIRNLVARVVSMTHQQISVQLLQSYLDLKGDDFTAFVKEQNWEVKDSIVQIPVNKDNEAKTVVIRENIKFEQLTKVIGYSNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UH69</accession>
    <name>A0A8H7UH69_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 5B</fullName>
            <ecNumber evidence="3">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">INT43_001883</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252157at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16266">
        <property type="entry name" value="IF2_aeIF5B_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000013">
        <property type="entry name" value="eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000026">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000112">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="19">
        <location>
            <begin position="554"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Tr-type G" evidence="20">
        <location>
            <begin position="1171"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="515"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="625"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="676"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="516"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="544"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="676"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="704"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="754"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="816"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="832"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="871"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="962"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="989"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="1019"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1037"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1070"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1080"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="1103"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1146"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG2179034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1773" mass="195235" checksum="79153773CB7A30F4" modified="2022-01-19" version="1">MPSSLQNQIIVVGGGLSGLAAAHTILEQGGNVLLLDKNPFFGGNSTKATSGINGALTRTQVKLGIKDSAEIFYEDSARSARDLLRPELVQVLTGKSASAVEWLQDKFQLDLSLVSRLGGHSQPRTHRGKEQFPGMTITYALMEGFEEAAEKQPDRAKIIKRAHVNKLIQDENKNVIGVEYTLVGKGADGKTYQEHGPVVLATGGYAADFTENSLLKQHRPELFDLSTTNGDHCTGDGIKMTAAIGGKTIDLEKVQVHPTGLVDPNEPDAKVKFLAAEALRGCGGILLNAEADRFCDELGHRDYVTGEMWKNKFPIRLVLNSAASKEIEWHCRHYTGRGLMKKFANGRELAKDMGVSPEKLEKTFESYNAICNGKEKDPWGKKYFHNFPIKMDDYFYVAHMQPVLHYTMGGIEISPESEVHDASGKAIPGLFAAGEMCGGVHGANRLGGSSLLGCVVFGRVAGATASKHLFGKLVNNSSAVAQQRLGNIAQHLNGGIGINIVVNPNEPKVNFEISWPGASGAPQIGAPQQQQQQETSAVEPPSGDIKKEEAPKKMGEYTAEEVAKHNKPDDCWVIVNGQVLDVTEFLPDHPGGKKAILIFAGRDATDEFNMLHKPDVVEKDEEFAEDAAATGAATEIPPQEDEEAVQNFNSNTSDFGVLANVDEEEGDSLMALMSKAAKKKGKKNKKATADEDLDDTPATPPAAPEEEPEEDDYDWADQPKNKKGKKGKKDLDAGSQASDSRSATPLPDENGETGEIRILTKKEKEKLKKEKAKEAKKKAAANKKTTQKAEDEELDNILNAQKEEQPTTAPESAQQEADEAADEAEGDGDSKNKKKKKKKGTKKAEAVEEAPVEAPTKGKKKGGAPIAALRKMMEAQRAAEEEARRLEEEARARAEEEEKRLAEEERLKEEAKLKKKEKERAKKEQLRKEGKLLTKAQKEAQQHAQRRLQQMIDAGIKVEGLMNKDGDNKVKRPVYDNRKKKKGQQSQEEIAKQQEEKKRLEEEEKKRKEEEEAKKKEAEEADEEEDSWENAADSEPEEKAGEDIKDSWDQESEEDVKDSWDASSADEEEAPKAEAKKEVTAPATKPAPAKAAAPAKAAAATEESSDEDEEEDSDEDSSEEDSSDYSDSDDDSSDEELTATQRQALQKKEEAAARRMERHKEALAARTKDDLRSPIACILGHVDTGKTKLLDKIRQTNVQEGEAGGITQQIGATYFPGDAIKQKTAVLGEKAIGEELKLPGLLIIDTPGHESFTNLRSRGSSLCNIAILVVDIMHGLEPQTLESIRLLRDRKTPFIVALNKIDRLFGWKPIPDNGFQDSLAQQTEHVKREFENRVEQTMLAFAEQGLNSTLYYNNKNFAKYVSLVPTSAHTGEGIPDMLNLLVNLTQTRMSDKLMYITELECTVLEVKVIEGLGTTIDVVLVNGWLREGDKIVVCGLNGPIVTQVRALLTPQPMRELRVKSAYVHHKEVKAALGIKISAPDLEKAIAGSRLLVCGPDDDEDDLKEEVMSDLTNLMSSIDRSGHGVWVQASTLGSLEALLEFLKVSKIPVSGINIGPVHKKDVHRASVMLEKAREFAVMLCFDVKVDREAEDLANELGIKVFKAEIIYHLFDAFTAYHQQLLEQKRKDQAPQAVFPCILKMVPQAIFNKKDPIIMGVDVVEGVLRIGTPICVIRTDPETKVRETITLGKVTSMEQNHKTVEVVKKGSSGGGVAIKVECAVYESPKTFGRHFTETDEFYSKISRQSIDVLKESFRNDLSKEEWALVVRLKKILGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHL0</accession>
    <name>A0A8H7UHL0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_006943</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHL0"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="329"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2182017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="682" mass="77838" checksum="6168A30A0AFB60C1" modified="2022-01-19" version="1">MVEDNFTSAKRVRTTVAFKCNADRPMCERCLKHNFKCTYGGETKIDLFQLTSINETVQAMVRRMDKLEDTLTQLCRTTNSLLTKLDSESNHQMNNLSCNTIRSKDWSLSLNSPNFQIAGNGNLLSDLYQFLVRDSKQRGQSMSETGSVVMPSSPESVDMGANNERTESVLGAVVARNYSPWKSTLKTSTFPLYNVWESNNNAPAQSNMDITNLPQETLDQMMEHYLNCFLCLPSPDVEALLTQYKQKTLCSMLQNAIMAWSARHAAIYHGMFQGKDPNVVGEQFFATAKELLKTRFLEPTFDTMHALLVLYIYAIGKSGGSRSQTLSEAYMYLGLAIRMCLDMGLHKKNEEEDEIVTEKKRRLFNAASFLETLCSAHAEKPFLFPDESTITVGNPSVLSHETGDQRYRVEFVIYRQQINKIHHEIAATIAAEEPMITSILALDQQLKDWYQQLPFYLQYRTSDRQSDKWITASFREQACIKLGFEYHFQICQLYSTFLSRPGKQYSPVSSDALQTCLYSCDMISELLDCWVLLEQPWCHFTIETLLMATLIYGREVSSSDIASARHAKQQLTKYKRILSEAPVRHHMHVKRLVKQIADLLDQSDSELPLNTMKSPTIEFKSPNSDTFSTQTDFYAQTLPDDDMSQLDLLTVPYDAYEPSDLYGTGLYQFTDFIYTPALHGHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJ15</accession>
    <name>A0A8H7UJ15_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_006553</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJ15"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="44"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="209"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="489"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="704"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="546"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="707"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="741"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2183547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="751" mass="81934" checksum="21D9AB24BD1AB48C" modified="2022-01-19" version="1">MQMLQESPTVQNDLTFSAPFFAINLPTVDASQAHLTSPASHYKPATGLAGGSQLSPPTSQYDSASGLVGGSPLNGLSQSPQDVMYSSAPIQFETSLLDQNSDDDSPVSIPSKRGISRPCKRCVALGKEDSCHDIAHKKRGRPKLRDKASMMQGHFLANERKYEIMYDAIQNPAFAANAQRASPSQRPQLTPQPHQTGRIAFVHQTIQEFHEQQQQQQREEEQIHERIIPRSFNRSNSVSSEKKSLTPQPDANLQQPQPLKNDHTPYLSSIDFNILADDPESSMLQLSPIQSTNSFLSLTSALSPTLPDVQQQQQQQPRDNHALQVTIFMSMEVCCARASDEVNDSWGYYPQELAHRSFYDFVSAKDTDRLAQLHRLLLDNVQSIAEQHVPVQNRPPRLPRTERTTSDLFYDTSPDKLLTPAQGSNTYSDTVHIKRRDGELELYSMKVYLGGGFGADLLNPDTYSKLYIVAIMDKYQYAVNNGSNSNFEAPARSNFSEGRDDSPMACDSPQPPTTTTTTTMDTTEVKSGILKGSGDGDRFQAFRPLSSSSSSSNSSSFPGSSSGPGSGDSRLSKSPPRPINYLNSATPSNQPPVSPKINIAPTTTGTNNGMLMGSSNRFFPKTGNNHGSSSASTSFRTMSLNPITGNLPNAAFFTRRNDSFSSPSNRFAPTAPVARASTYTHPTTQYFLQTSSSTLNAAASAAQTKTRGSGYSFTPMTSVRGAADDLAPNDRATGKTESNPKMEMSITSLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7ULD3</accession>
    <name>A0A8H7ULD3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7ULD3"/>
    <dbReference type="OrthoDB" id="436519at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051948">
        <property type="entry name" value="Hsp70_co-chaperone_J-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="9"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2186037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="270" mass="31016" checksum="8307488F95637AF9" modified="2022-01-19" version="1">MTFQELPMNYYQYFGANCQDLDLGQLKRLFRRLSLVYHPDKNPDPEAVDNFMRLRAAYDTLIDDKKRELYNRIGPSAIANVKSATAFKYVDSSVRQLAIDHAMTLIIQFGLSYITPAMRITWWKLVMLAVFIVVELNLISSPTSCGIRVFGYPFLLHELLQLTRQVYYSLNVALSRIVPHFFHETQTISDADVYQVNHMSQLERSFSRQEFSNTVQPFIQEDGTMIEELRLELVKGQQSSQTSGSRPAPPPIDLMAQHIIVNWLASVDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7ULH7</accession>
    <name>A0A8H7ULH7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_006208</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7ULH7"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2183204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="467" mass="50637" checksum="B6741460D1D84F0D" modified="2022-01-19" version="1">MGFRYSDPYVQVMLIGFICFCCPGMFNAVNGMGGAGQADPKTSDDANTALSVTFTVCSLIGAPVYNIFGARVIIPAALTYVLYIGSYLTPNSGFTIAAGALLGVGAGFLWTAQAGIMMSYPSEAEKGKFFATFWMIFNLGATMGSAIGLGKEWSSGTAQKVSVGTYIAFMIIMAIGALLAIALLPPGKVIRADGSPVSLHKFSNWKREAFEILLLFKDWKMLILIPLFAGSNWFYTYQFNVYNGGGFFNLRARNFNNMFYWMFQIFGAGLFGFFLDMKALGNRKSRAFIGNTFVLCFMSALWIGGIFVQKKFTRESVAALKKDPTMQTDVFTPGYGGLLIEYALFGAGDAIYQGFIYWLMGTMTNDTERAARYGGFYKTIQNAANAIVGQVDAIGTPFMTELAVSFALNGAGLLLAYVVCATVPDVTEETVNNLEGVDGDAKLVGGHVEGLETENTYEKQSVGDEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UM84</accession>
    <name>A0A8H7UM84_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_000856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UM84"/>
    <dbReference type="OrthoDB" id="10295039at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2184943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="514" mass="57595" checksum="B30D59622D902E49" modified="2022-01-19" version="1">MSDKATLATNVTINEYMTRPDANPHIPLLDVPITRISDLNLTNYMQYVCTHFDFCNIGEQEPGRLIVMPPAATNISNDHQYSRNIMLTKSASNLASSYATYLPNETLSYHIATKNNYTTGLMLESMRNLMSSYKLLIKNGPIVRLSASNQDPTLGLLTQGSAYAARYTNLFSVLNGTNALGVFETRSVDTMSLRGLSMEQAYTMLTAHVNDSSMASRNLTDCFTAQMCRVLRLSSTSQGDYVKMILMGRQNDTISATYAVRKARYFLMQLDEDVGSPAQSNYNGSLVDDYAFGWQHLVPIMQLSVVNSSYVVDGPSTYTTHLSYDYSNLTDNHMHLVASHLNCSRNGNLTVPTNKRSYTAATDLKISILILRMMTLPHYYENLFWTLPTCRMTDNASDLSHRFTVNWSLMIDEELKQVTPIYQVIKPGGPRPVRDSVIRSSLNTRTSLSDPRVSNMGLDEVRNITGKNSDSAIFGGFKEYIEELCPSETSLQRLYHGCADDESVEQLEYRNGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDH4</accession>
    <name>A0A8H7PDH4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-acetolactate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_001390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S)-2-acetolactate + H(+) = (R)-acetoin + CO2</text>
            <dbReference type="Rhea" id="RHEA:21580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15686"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="4.1.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; (R,R)-butane-2,3-diol biosynthesis; (R,R)-butane-2,3-diol from pyruvate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-acetolactate decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.5" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDH4"/>
    <dbReference type="OrthoDB" id="509395at2759"/>
    <dbReference type="UniPathway" id="UPA00626">
        <property type="reaction ID" value="UER00678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047605">
        <property type="term" value="F:acetolactate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045151">
        <property type="term" value="P:acetoin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17299">
        <property type="entry name" value="acetolactate_decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.80">
        <property type="entry name" value="Hypothetical protein, similar to alpha- acetolactate decarboxylase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005128">
        <property type="entry name" value="Acetolactate_a_deCO2ase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01252">
        <property type="entry name" value="acetolac_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35524">
        <property type="entry name" value="ALPHA-ACETOLACTATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35524:SF1">
        <property type="entry name" value="ALPHA-ACETOLACTATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03306">
        <property type="entry name" value="AAL_decarboxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001332">
        <property type="entry name" value="Acetolac_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0005">Acetoin biosynthesis</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2171914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="243" mass="26980" checksum="AFBF0EDD2494C713" modified="2022-01-19" version="1">MASEQISSSPGHIYQYSLMSALLVGETQGGLALKELTKRGDFGLGTFQLADGEMILLDGTAYHMKHDGSTSVVQPDTILPYATVTTFKPTIKSQVSNVTKDELQRHIEHLTPTAGNYFLAIRMDGKFKKMKVRVIKAQDVPGESILETVRKNQREIETENVVGTVIGFRAPECYQGLTVAGYHLHFINSERKVGGHCLAYEIEAVDIQVSIIRKLYTELPDREDFYKADLSLNQEGIVSVEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDS0</accession>
    <name>A0A8H7PDS0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_001526</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDS0"/>
    <dbReference type="OrthoDB" id="2139348at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF31">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="26"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="139"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="250"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2172049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="37483" checksum="EFD363BE825A77B9" modified="2022-01-19" version="1">METASPQHQVVVDRLTPVHGQKSNMRKQMDDLLFGSVAGIVGKFVEYPFDTVKVRLQTQSHTNPKFSGPLDCITKTIKEHGVKDLYRGLSSPLVGSMIENAALFVGYKQVQRMIRDLSATPEQKIQYAQEHGDESLQQLSLNQLIVAGTISGAFTSLVLTPVELIKCKLQVQQHGSPSTIHFRGPLHIISHTFKQNGLMGFYRGHLATFVRELGGGAFWFGSYEYICMLFMRHHEKNTGKRFTKNDLAPQELMAAGAIGGMAYNFSFFPFDVVKSHMQTEEELTGVKRRFGQVVKSVWQGAGIRGFYQGCGITVARSAPTSAIIFMTYELLSRHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDT6</accession>
    <name>A0A8H7PDT6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_001538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDT6"/>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07516">
        <property type="entry name" value="HAD_Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10000:SF8">
        <property type="entry name" value="HAD SUPERFAMILY HYDROLASE-LIKE, TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10000">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2172061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="289" mass="31519" checksum="E33A7E5A576F1909" modified="2022-01-19" version="1">MATSNFKNIRLVASDLDGTLLVHSDMTAQSGGAPSPRARTVIHKLADKGVRFVLASGRPPRTMDCAVEQVGLDNVLTICCNGGLVYDPFNKNIVKKYSIPNKDICSILDTIIKCLGPQVCLGAESGLHFVCDENYVKERNDFLDHHYIVRKPMEFLQTPEDTIEKLVIILPGMPAEKLNERLLELFSSDHWKQVVNITFSNPHSIEISAAGISKGSALEDLCQELGVKAEETIAFGDMPNDSDMLKFAGTGVAVENAHPSVKEIADRVTASNVDDGVAIVLEEVLEQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEE7</accession>
    <name>A0A8H7PEE7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Chitinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_004940</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEE7"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="2 8" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034134718" description="Chitinase" evidence="10">
        <location>
            <begin position="16"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="12">
        <location>
            <begin position="18"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="11">
        <location>
            <begin position="153"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="219"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="202"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2172398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1065" mass="116916" checksum="0841848CBFC891EC" modified="2022-01-19" version="1">MRKLILLAFISTVSATCTFITQQPGQYCHDLAVRCKISDSDFYKYNPNLKTDCSNLSAGSRVCCNAGGLAPPPNSDGSCANYTVIPNDNCGAIGGHYGLTIDQINNFNFKNTTSFGGTWGFRGCQNLQPGNICISKGTKGPIPGVQKDAQGNPVSCGPTASGNGTNIQCPLKACCNNWGQCGITDDFCKITDPKLNPGVSGCQDNCDISYVKGSAPANFVKVGYYETWNQKWPCLNTRIRDIDLSSYTHVHYSFADILPDYTVYLDQLAKAQFNDFKSLSGVKKIISFGGWGISTSPPTFQHLRLMVQNPDKYVNALVAFVADNNLDGIDIDWEYPGATDIPGIIPGLPSDGPDYLNFLTMLRARLPSSKSISIAAPASYWYLKNFPIVQMSKIIDYIVFMTYDLHGQWDYSIPSLGPHLLSHVNWTETQSMLDIITHAGVASNKVLLGLAKYGRSFQQTDPSCYGPTCKFTGPDSGATPGRCTNTSGYIALAEIKDIISTGTVRKTYIDAGSQILLYGKDQWVSYLTDDQLTSRTNTAKSMNLGGTITWAMDLDSKQAVNTCDMSHVMMIGDLKNTVCSNNDMRSYFVSYILDAIEYWNAHSASYDAGMIAFKKYYNITVAHPTKESYDSVFTTMSNFISALPSGDINEEQMSLLYFYAKRSAVFYQPPKSGNKKRFISFSGSFGAGAGYIELTDMAVEAGAEIGAVTAEATAAAVGSLASLSIPFVGEAVAIGAAIFGVFVGLWNKKSTPVPDSVITLAQSNEQQLDTIKGLILDPNSVADYYSSISSIDYGTDIDPMDYDIIPGPYTKLTSYVLNRINSPYYWNLRKKSTSCKADDQVNINNEQYDQLMTKLTNKNKEKAGTPVYWINFSGRSPGVACNAWFYFSKKMLQGDDISTINTYTRFIAGKDRKYYLDKYDCSKYGKQSQTDRNGVTRQVSIYQKDEFPFAGTYEGMTVAQQEYDVSIACVDGSDNGSDGSYFGQFVDALSIYQPYNDHIVGQSSGARQGPLTDHQAFIIKIHSLPPLDQCPENTLGSTFIRGFAMTPDGTNRRPNVINHFYESIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFU1</accession>
    <name>A0A8H7PFU1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_004546</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PFU1"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11713">
        <property type="entry name" value="GINS_A_psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21693">
        <property type="entry name" value="GINS_B_Psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055221">
        <property type="entry name" value="PSF3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF1">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22466">
        <property type="entry name" value="PSF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034661524" evidence="6">
        <location>
            <begin position="20"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein PSF3 N-terminal" evidence="8">
        <location>
            <begin position="514"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="578"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2173172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="687" mass="75476" checksum="C852F4DEBDAF31C3" modified="2022-01-19" version="1">MVMIQAASVALLALTAVAAQHSSHAGHGHSHGHGHGHGKTPSGDDWTKNIKNVVVLVQENRSFDTLAGGFTYDSSIDGLVGKQFCNPMNITQPTQNIVCADKIAPAHDVAIDDPNHSVTGTSFGLYSTYHPDEAGIKDGQVHATLKGFVQEQQVAHKFTGNESRASEIINYYTSAHIPVFEDMAKNYVLFDQWFCDVPGPTNPNRAYVTSGTSHGHGSNDAGFDYGGLPQKSIFQQLSEKNVTWINYSNSTDNGKGYGTPEEFAAKSVSGFNPDSLFYNWTWTSGAVNNSVKGIAQFYEDAKNGDLPQFTYINPECCSFDSMHPPSPISLGENFIKGIYEALTSSPQWNQTLFILTFDEGGGFGDHVVPPVNVPAGDGITYTEKAADGKNATFDFTRLGVRVPTMLISPWVGKGVVEHGGSNKGRTYSHASIQATLSQLWDLENLTPRTAWSSTFEHLFLDKMRTDTPATLPPVNSCSGVEIIGGEILDATFRVSRLNCRQSHLSMNSLGDEYYDIDSILAEHEKLPGRFSCNVGAELNLTGEGIEVPSGTKVELPYWLASALATFEDLFAVEMPRIYNNRVRNAILAGPTSLDTRRIHPYFNRLGSMFARNFVQEQLIIILKMSFIARLYMIVDHAQTVLNTDSSHFLRRLDETERYLFKVAHDSAVAVKHWQSGSKNLLQQATPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PG45</accession>
    <name>A0A8H7PG45_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">chitin deacetylase</fullName>
            <ecNumber evidence="20">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">INT43_004624</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="20"/>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PG45"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10952">
        <property type="entry name" value="CE4_MrCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000004">
        <property type="entry name" value="Related to Chitin deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF98">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="18" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 23" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034695955" description="chitin deacetylase" evidence="23">
        <location>
            <begin position="19"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="24">
        <location>
            <begin position="171"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAG2173250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="441" mass="46726" checksum="0C5F1263C8DC9258" modified="2022-01-19" version="1">MYWKSVVAITTLAAAVQAVEKKAASSAAKSSSAAPKSTAAAAAPSTPSSATNPLAITIPSIPQTTSYDPTVECQSYTVPGLTIDPKEWPTIWETATSNGMNTSAEFTQLYNSIDWTKAPAAPVRKATAAGGLDFAGYDANNDPDCWWSSSLCTIPKAKDVNADIYRCEEPETWGLTYDDGPNCSHNAFMDFLQQQNLKASMFYIGSNVLDWPYGAMRGLKDGHHIADHTWSHQLMTTLTNQEVLAELYYTQKAIKLVTGVTPKYWRPAFGDVDDRVRYIATQLNLTAVIWNLDTDDWAAGNSVPENTVEQTYQDFITMGTNGTFATSGNIVLTHEIDNTTMALAMKYLPQIKQAYKNVLDVATCNNITQPYMESAVTVTPFGAANASTSAGAAASGASGASGVAPAASGSAAPSSSAKSGASSLTAPASLLALVALAVFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PH15</accession>
    <name>A0A8H7PH15_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ARMC9 CTLH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_005198</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat WDR91 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PH15"/>
    <dbReference type="OrthoDB" id="193023at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141039">
        <property type="term" value="F:phosphatidylinositol 3-kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051898">
        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056327">
        <property type="entry name" value="ARMC9_CTLH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039724">
        <property type="entry name" value="WDR91"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13083">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13083:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23138">
        <property type="entry name" value="CTLH_Armc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="ARMC9 CTLH-like" evidence="8">
        <location>
            <begin position="46"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="304"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="454"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="238"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="560"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="184"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="560"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2173778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="689" mass="77165" checksum="F588B9E642F676CB" modified="2022-01-19" version="1">MNSIYQVDDLVKEYLLFRGFTSSFRALELESRVDKDKGFQVDKIIEELFGYVHNSEISNLMDYWRYLDTRYFSRLDSRFQRTVKKFELCLLRYYLIHAMQAKKRDKVIEFFDVYGAELHENPEWLKWFALPYSKNPTTDPAFETFFSKQWLDNYIVSLHNFLNTIFQNMPLPSLLAINLDRLQRKSQQNEIESLKLSIDSLKSNVEALEGENLSLKQKLTETKKEMTDGMTRMRRRAVSMIDAKPRSTISNSESSGKLEASSKKRSSVSKSKSIAEDDGDSDLSTTESVSDSNETFIITTQEEFFEHTSGITHAKFSSDGTSIASCDMDNIIRTWSYHDQLSNPSKIKNASNVLSLEWEARSNKLLLIGTDSGLIRVYNTESQSIVHNFRTDDKYSRITHLSCNPSEPAFVSSASNVLYGAQNASAGSLTSWNLKTMQVQQTFVLEGEEASSFVNSVQFNHNGQLFVTGNDDGLIKIFDARTIRPIMEWKSKDSVASCFAQFSFDETSILDVSANGTFTQWSIHKPGESVSSVKLAGFPPPSPFSTPESAAATQSPIDIPASSSAIHDIPKPRVSSSSASRRSVSSMRSGRLPPMDDTVTQNLLSVTPRPQMVAFSHDTEHLLCAASASEEAKTPVVGMIYQVSSGEPIQQVTSPQNEKITVVDWTSTANACLTGTADGSIRVTKLLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PH64</accession>
    <name>A0A8H7PH64_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_005023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PH64"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="208"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2173605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="457" mass="51721" checksum="7F71327A4C7917BD" modified="2022-01-19" version="1">MQKPNAFDITTFKPHEDTNSILDLLEDVVTNDHTYLDKEAQDLVELGDEYSLQKDYKQAKFWWKKAAGKGSAKAHLRLAYYHRSVEWNYQKSVQNFKAAAKGGNVQAQCQVGELCYDSNNYKGAIKWFTRAAERGSTTAQRKLGNMYYTGTGVKKNLEFAAEWYHRIASEESITKHEVRNSHDAIHNKSESKEQAARNLTIRTRSILIYIVYYSVSDHIYTIAKEVQKGLESQGAKVKIFQIPDNFANVILPIVVRPWKNVPNINVDNLKDADGILWGIPIRFGSMPVQVKAFLDDTSRLLSSRALAGKFTGIFFSSSSRHDGQETTAFAALANFYRHGMLYVPLGFSFARIFDQTEFTNGFVYGAEAINDINAARKPTKEELDIAQKQGINFAKVVKAYRYGEQWEQQNLNKEFTAETTKTNRHGFVDTGTEKFSRLAELQAVDTLSSSVGLSSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PH75</accession>
    <name>A0A8H7PH75_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_005038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PH75"/>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051453">
        <property type="entry name" value="MBL_Glyoxalase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46233">
        <property type="entry name" value="HYDROXYACYLGLUTATHIONE HYDROLASE GLOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46233:SF3">
        <property type="entry name" value="HYDROXYACYLGLUTATHIONE HYDROLASE GLOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="174"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2173620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="429" mass="48536" checksum="C02DAA01ABAC344C" modified="2022-01-19" version="1">MDRFSPEAPNDKVYKYTCRANDYFERQLYVDAIQDYTRAISAIAQADDQHYCALLHSNRSAAHYRLKNWEYAENDAAETIRLEPEWAKGYFRRAEALAQQGQYEKAIELYRIALEKEPDNPDISSRIAKALIESDNAKMGFQVIQLIPGRDICIERSIKNPIQNRIYEFAQIMRNIIYVVVDLETRHCIVVDACWDVDGILKFIQDQGYTLVSAAVTHYHFDHVGGSPPPPYDNIPIKVSGLATLLKRLPHIKAYVHPKDIPYIAQANPSIPENRMVPTGTEVTETLNIGKSTKVRFIHTPGHSPGSQALLINHSRLIVGDTLLCGLCGRTDLPGGDRNMMEATLRHTLGSLDDRVVVYPGHDYGYEWSTIGIEREKGCLGEDLVGFEPRPIIDEEKVVTKNIPKRRSMLSSLGAGLKNKDRGHWFFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHA8</accession>
    <name>A0A8H7PHA8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_005253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHA8"/>
    <dbReference type="OrthoDB" id="2128042at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031606">
        <property type="entry name" value="Kch1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424:SF1">
        <property type="entry name" value="LOW AFFINITY K(+) TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16944">
        <property type="entry name" value="KCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2173833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="482" mass="55496" checksum="18CD960B7C34A80C" modified="2022-01-19" version="1">MGKKSGPKWKREKVQDHKFDFVDVQEFHDSSCLMRLRYIMLFLVVLKSVLVYAADMWTAVSLLVVGSTTTLAELDIGIPLNVSKYIFLGAILVSFLLLFWDIRKGRIIVASRDISYTVTSVFASRYYSLKDYSYYCFFCKIQKSKRTTDEIAFFVFFTLKGWKRLLLAEAPRQVINAVTLYALIRTWLKKTVTLDSIWDGMGHSVVAKMMTGTMAFSFAIFLVSFIMICIAAIMYIPLLCHIQGNLKEYCCHKVDKRVAELLRKQAKKRQAKNGQANNGQARNGKAIKENIPLNNMVKPTLPSVNLYEEEKRFHGSSYPGHVGTPVSNYNEPQYNNYMVPPVGRRGSTDSYGSDMAGYRKDQYGWSHSPQPSYPTPVPPYHNTSPRMDNYQPHDMYSEADHAALLQHAADPYMRRPSGESAHDMDAYYNGRQQDYYNSPHRNSPRPALANTPGRYPDQQQYHHQQQQQQQQQQQQHHSYRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHL4</accession>
    <name>A0A8H7PHL4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pleckstrin homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_004200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2149224at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032065">
        <property type="term" value="P:maintenance of protein location in cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053005">
        <property type="entry name" value="Nuclear_Pos-Cytoskel_Interact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024774">
        <property type="entry name" value="PH_dom-Mcp5-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190:SF2">
        <property type="entry name" value="MIGRATION PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12814">
        <property type="entry name" value="Mcp5_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pleckstrin homology" evidence="3">
        <location>
            <begin position="1135"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="482"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="824"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="875"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="997"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1088"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1275"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="195"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="569"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="877"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1003"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1098"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1286"/>
            <end position="1298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2174179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1369" mass="148468" checksum="6FC594C98D630ABC" modified="2022-01-19" version="1">MSQESPTTPLPQTSSSTPVSQPATPKPLSSSVSLQTSSTPSVRTRRAQTPDKQQGPQASQSDTTQNILHKYANQSRAKEVDTQSSVDEEELPPATKEKLKSLERELNEYKSFAGIMGASPLKRPEKFMSRNSTGDPLPTPTSSTILPPPSTSSLLPPPPQSSTPTKRRSKVPNADRRNNDIEFATEIGQGLLLEVRKMQSLLQEKEEQLRALDREKAESERLAELLAKQLKQSQENEEHLKEDAWNLELAKQELGGNMAELQHSLSKSTADQNKMSKQLTTLTQEVEVLRSTEEKLSTQIETMKSRHEQDMNAMRKHSSSLQREKTEITKQLETTTAELVTIRSQSKAHRRSVDAENLAHGDGANNLGSGDENYAQKHGDSPNASPPPSPTHAPRNHALELETLKTSLGHAHRMISNLRSSLHKEKQDRFEMKKHLADSQETIEQLRNGSHMWADVGADRAGSGAVAGDGTVAGNAAAARRLKKAANKKRTPARKAKGLTPRRPSDTDGDEYEDVDEMEIIASDISDEDGFDNITDKPHTTTTRSDTGRRGRRLRKWEGASETSDSESVHTSDAQSSLDLSQGNFVPLSSELSGSKGYRSAVDIAVNTEPINIVSDIVEQEQKKPVMVDIGTNTDEISAPKVLSMDMGMNTEEFTSDITFVDASVNTEELTSDSVDASVNTEEPVSNIALVDASVNTDQLVSNIASVDTGVITEVYQPAENYNAGAALAGGAAGVVAGMVAEHELGQHESETVTPIAHVQKEAAAKTTEPAAMLPDATEVVTSLQKSGADRNVQLSRVHEDRHTDKSVASSLEAAQKVAPLPVDQATDTGPAVSELDNTDRTARQAQVSAERASAAAASAGITDIASQLHKTGDEIASQSNTSSQKEALSAIASSNLPRTVLSNNEEPANMADNEQKRGVANIDSKTSFAPPETSSQLASQSAFINHAEENGETGLATSKAGAANSDYFTQNAVDDTSFNPTHETAVQQHPTNEQIANNMPGVEHHNEKSDTQNKRDSKILAAAAVSGATAGIGMADSAEAHKMPAEHVVKADSRRKNEQDVGHATIYTTTYPSSQLTEQNLKVLSADPDSNGVPQQKEADVVSHSDAMSRRASSSIYKPISEKEGYTSSIAPNVVSNITQTMIGSWMWKSTRKTIGSGFSDNRHQRFFWIHPYSRTLYWSMNEPGTNGVAKAKSAYIESITAIQDRSSTSDLPSVSLLVKTNNREIKFTAQDIAQHEAWLQSINYLLSRPFNGTGSMMQSKKDVGSVRSIPSVAMRKPSSQRIHSVFSSSASNAPSRPDSHRYAGDGLNDEDLEDLEDVRMCCDGKHHLSKLEKHHSHRSSRYRPVSGTSFEHQHFAMSITSGNGSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHZ7</accession>
    <name>A0A8H7PHZ7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase type 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_004385</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHZ7"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="5">
        <location>
            <begin position="87"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2174362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="283" mass="32473" checksum="5FF37600E48181E5" modified="2022-01-19" version="1">MTEFKEDFQVGPETITLFDNYLGISDANDLRNHILAISEKLKTSEKTYRCLREYKFVAPRLAPRFYYQHILEDRKRREQNGENPIFMDIGCCFGTDIRQIILDGYPAKSIVGVDLYAHFIRLGYELFQDQGKLQAKFITGNIFDEQFLSTSDEQPSDQPSNLNEYKHSVTYLNAGSVLHLFGNEQIRQFIRRAALLLKPGGLFCGAHVGGNQSGTYERLFDGSIKYFEGKDSLKVILEENDFADIDIRATRRVGDPDFKDDKAKRDGFEALWLNFSAVYSPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIP9</accession>
    <name>A0A8H7PIP9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_004312</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5378913at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000045">
        <property type="entry name" value="Two-component system sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF78">
        <property type="entry name" value="SENSORY_REGULATORY PROTEIN RPFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="457"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="839"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="1006"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1288"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1508"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="295"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1430"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="635"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1433"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1450"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="907"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1340"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2174289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1633" mass="181963" checksum="19C9DD499406A517" modified="2022-01-19" version="1">MSHRNESSMTTSDVAVVNPQSTSPESVLDFRHASANFPYTLKGEAAVLDLLHTIPWSKTSLGPARNWSPILLNTVRLMLVSRFAMCCWWGPELRMLYNLKYASLLGKRHPKSFGDTLRSSWHDVWHDISGLIKAVFEDGESVFLQEARYWMTRNGWIEETWFTYQYSPIYDDQGQGPHGVFHVVTDETLRVFSERDMRTLRDLSTDTNTCISFNGWKRSVAKTFKDPNHCIDIPFIYIYEIDRETREFKRVISEGANPEQKKLQLPQSIPIWEEFDVVKSDSFSAENMRIPSKKFRGSEASVETSTMSDMSEAPNGSLEVPKPQKPDAILKQRLTKAMNDCYTHNSNAMLKLPVECLSRPNIVLPDSEKKLLTLIPSYTAMVAPIHGSSNNYSDVSLIAVLGINRFREFDENYQSYFDLLMSQLSSSLATTNAVEESQQRADELAELNRTKTTFFSNISHEFRTPLSLILGPIEQVMQDENLHPKNKDMAQMAHRNANRLLKLVNSLLQYTQLENGRMHAQFKAIKNLPDITREIASAFDTVANRFHLQFIVDCPSWEWSKPTNRKISQDDISAFVDVDIWEIIILNLLSNAFKHCLKGSIRLTLRRHLRPASSSPSAALFHNPLTTTMSSSHQVSTPDSTTSNSSTNVSSAGYYELCVTDTGNGIAASDLQRIFDRFYSVRNPESRSHEGIGIGLSFIRDLVESQKGVIAVESALGQGSTFTVRLPLGYRHLNQEQVIRNSESGSNVTSPDKSLSDKLSSISMVDVKAKEGQDVNHIFPKAGRLFVAETAGWNTLNGDEDDQLNPEINQVVQPEPVVTPTAEVPEYITVNENDIFKPTVLVCDDNFDMRSYIKHTLEGNFNIIEASNGRDAFNIAVSLAASEAEDPNQPAEEVHIPERKIDLVLADVMMPVMDGIELARTLRAHPMTRTLPIIMLTARAASGDSMSGLFAGADDYLYKPFDAQELIARVTTHCNLYRMRVEYADARNKIAVLEAANDAKSKLIALVSHELRTPLQSIIGTVELLREGNRFEEERTDLDNIHYSSQVLSSLISDILDVAKIDAGNFVFEPADFNPRVLAQHCCDILTEKANAKGLDLVCHVDSGVLQRVNQDPARIRQCISNMLSNAVKFTERGYVVMRLYSVIKYDDGRPVRRFSYTELPSEDHWPDQSSVDGDPNASIQLLVEVEDTGIGLAEESLIEIFEPFCQANNTSTRPYEGVGLGLAITKQLVEKAGGEIGLSSELGKGSTFWITWPVTPPTSAYRAPGEDQNADDNPTRAEDLQVPREISVLLLTKNQVTSAAIAEHIKSVKLQNITVSTDPTDALQQLSSTGRSFDMLITDSLLESSCIPVLRKCRELKIYVLMIVIRGVHRTLSKSLSELSDDVIARPVHRANLLDKLNKYAAERRNRKLSITSDRKLFIPKLEASLKKQLERASSTSTAPPNMSGAISAPLASTTRPPLTPPRSSDSFSTSDSTVYGNSTSESLPTVNTLAKIPEPAQQPSPSFKGKILVAEDNVINQKLLKKQLIKLGYESDVVSNGLEALDKLRAGNKYTAFLCDCNMPQCDGFQATALVRESEEDFRKIPILAISANAMAGDREKCLAAKMDDYVSKPLTIPQLGAALDRMLQRLGGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PIU4</accession>
    <name>A0A8H7PIU4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPI inositol-deacylase</fullName>
            <ecNumber evidence="10">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_005931</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="10"/>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PIU4"/>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056824">
        <property type="entry name" value="PGAP1_TMD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25140">
        <property type="entry name" value="PGAP1_TMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="644"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="699"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="801"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="876"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="11">
        <location>
            <begin position="79"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase transmembrane" evidence="12">
        <location>
            <begin position="604"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2174869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="913" mass="101572" checksum="E8966EEBE65E4528" modified="2022-01-19" version="1">MPRWSLRLITTLGLAVLVSLFASFIYAPRDPKQCNMSFSRPIYIQQTTFDTSWSALAKKYSLYLYREGGIDYRDIVNRGGQPVLFIPGHAGSYKQSRSIASETTVQLHTLLNHQQGDDYAKLDFFALDFNEELSAIYGPTLLSQAQYTNDAIRYILSQYKYASSVIIVGHSMGGVVARILPLLPNYTADSLNTLITLATPHSTPPVFVDQTISQIYKDITSFWQRESQNGSLNAVALLSIAGGNLDAIVASDTSSVHGIVPPSHGFSVYSTGIPQVWTGADHMAILWCNQLIQRVSTAIIKIVQPKIPYSIKPLDSRVRIFRKLLLTTLDDSDYVYSLGASVTKKFDATHIYATTATNLHFQSSELPSMPVILDARTLQTLEFRLTTVADQNTNIRVYVCQYMTATDELKCQSIMKNSVTLPSYQLGQNIVSAHIPHLFLQNADYIYAEISNIPTEGFIRTQFYNATQQLNTHNVSMTSIALQRSVLEFPHVESGMMYFPRLNNPLFRYKLSLSKSTMPDCTDDTSPVIRMSVKDRHESKYFTDISKPVHLAFHGESAFASNQHLLESGLQLQVWNQPKCPLQAQIELDIFSSLGRIVMQHGIVLAVLPLMFSILVFLHQVSIYEKTGTMPSWTAMAGKQYPRFFAIGACALVGISFIQICYHSGSGARDASVFATYFSAKIGQTGLGVASIDVVWPSLILLFSGIGVIALIIFVLHLTVSIISKTLNVIQGPRGGKPHSPHVDQPAWIIIWTIATMLISRFVLPQVLFVVAFVLQLFFCSKALTASSFQETQHALTLSRYQFSILVILFSLLPFYAPAALVWTQDLIMGWYEFPSSSSLPHTLHLAALVSYLTSLRLRGGVTLPKFGNVQVTMELLLIICGFAFGIRASYAMSYVASLLWIACQVQTKTKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PK07</accession>
    <name>A0A8H7PK07_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_001060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PK07"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="15"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="236"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="408"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="241"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="432"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="470"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2175413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="620" mass="71001" checksum="AAF4D6B74D3A084D" modified="2022-01-19" version="1">MPASDKLATLVQWFEDNEVEWTKDLIEVKDTNGSLGVFAKSDIEEGLPVVKIPKVNILSSKTTGIANVIEDEQLEGGCSLALAVMYESAQGEDSPWYGYIQALPVMEDLPVFWSEEEQAVLNGTEMEDALENDKKDLREDYEEILKPLFEKYRYIFPEDQQEKFYSYETFCKISTLVSSRAFEVDAYHENAMVPFADIFNHQSGSEHVHFETDFDVCDACGALEYCEHRFFESDDDLHGAEDEEGGWSDVDEEDIEESGGEEDADEEVGDGDEKELDDDEESDQELQDLEALESKGINIYEDEEDEQPPKDTCDLVMDRSAKKGEELFNTYGDHANVVLLSKYGFCQEDNDNDFVTVDEDMVVDACVDQLAKILKEKGIKASQEDVINYVRMRWEYFIMNESVFLPDEHGDMEDDEGHDDHEGDGCGCGHSHGGDDEHGHEHAGHDHDHEHEHEHEHDPEGGCCDHEHGEEEDEEEEEEEEEDEYRPRPYRIEYSGTFEEALKYLLHIVFVDEQMFMKFVDNPEMALGYFAELADSETKVKPRSSKKGKKKPVDIFVNVKRNVNHVLHQLVLARQKAYDEAGIAGDQQALKTETNQRKRFALICRISEKQILERALKLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKG2</accession>
    <name>A0A8H7PKG2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chitin biosynthesis protein CHS5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKG2"/>
    <dbReference type="OrthoDB" id="245697at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17742">
        <property type="entry name" value="BRCT_CHS5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13945">
        <property type="entry name" value="Chs5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031673">
        <property type="entry name" value="Chs5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052827">
        <property type="entry name" value="CHS_Export/Cell_Fusion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031669">
        <property type="entry name" value="Fn3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351:SF1">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16892">
        <property type="entry name" value="CHS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16893">
        <property type="entry name" value="fn3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="80"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="173"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2175692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30394" checksum="4D6254B2C11E5722" modified="2022-01-19" version="1">MPPTETSVQFTVGKLDAGMAILLTEDHHLIEFPSLLLPQGVTSGSVVNISVTRNLSEEEIKMREFWDLQESIFESFGKDQPEPPVVRVRNITQTSLTLEWDPLVLHTAKLRSLDIYKNGTKLAQASDSQHHIPSDTNHIKLSGLEVDHEYEFYIVVKTTSGSLQSNHVAVRTHKMDNLTGIKVAFGTFEEPEPAVTELKELVERMNATWTDEVDADTTHLLAQLPGGANYEQAMRYSIPIVKPDWLVQCDRNKKIQAALPYYIVNVSQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKM9</accession>
    <name>A0A8H7PKM9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKM9"/>
    <dbReference type="OrthoDB" id="2122308at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04774">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="2">
        <location>
            <begin position="13"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2175455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="85" mass="10002" checksum="E11096AF6075C4D3" modified="2022-01-19" version="1">MGHSKNSPWVEKHDRHEQRSDVSNVRGDMKKHGAGIYNWGSIGDEIFEERQVHPRKSLIMEQTSDNGKVQLLDDKQFTKLRRWSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PL98</accession>
    <name>A0A8H7PL98_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PL98"/>
    <dbReference type="OrthoDB" id="2352273at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="203" mass="22552" checksum="5D8F0A55D738122E" modified="2022-01-19" version="1">MIGGTGAAPVQMKKRAAGATDPLFNLSENISSQLQIALQPKLRQFSNNVHRNIFAGILPHDNEFVVAFGERSGMKTEISHAITSTWAKEQADMRKAVLDAIKQDMENERQTIEDLDVAARRAREAVVEKIKVSVKAHIYDTLISEKVQPLLASAIGKSYTTDIGERIAKNIEGVTNLWLERTIMNQFCVDAECIDSQSLKLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLY1</accession>
    <name>A0A8H7PLY1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLY1"/>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19101">
        <property type="entry name" value="AKR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43147:SF2">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43147">
        <property type="entry name" value="PROTEIN TAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="349" mass="39993" checksum="7CB70E383381E47D" modified="2022-01-19" version="1">MIRRRPSFHPLPQTIELTPTLYFPRLLVGLWALSSDRWNEPVAEHKIVNELRQYYQNGMIGFDMADIYGPAEKIYGAFIESLKTSPPSSHLSSHLPQPVSMTKFVPKPGEMTFDKVKEAIEASLGRMKIETVDLIQFHWWDYSDKRYLDALTHLNELTKLDDPLVRHVGLTNFDSERLEEICQKVPNIRTNQVQFSIIDTRPEGKMRKVCERYNVKLLTYGTLCGGLLSEKYIGQSPPSSPTPSQAKYLQSILQWGSWDLFQELLQVLQEIAVKHGYTIANVATKYVLRQPHVAAVIVGARLGVNQHIEENWRSLECNLSDEDLEKIQAVQQKGKHLEDVIGDCGDEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMH5</accession>
    <name>A0A8H7PMH5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMH5"/>
    <dbReference type="OrthoDB" id="2499440at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23454">
        <property type="entry name" value="beta-trefoil_Ricin_GllA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="71"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2176924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="252" mass="28001" checksum="578C0D4AC96BB1A2" modified="2022-01-19" version="1">MASFPNNDDPAKSPTQSVGVLDFNRINSASSNQSSSQYKLPVFHFHSYGNDERTPTPPSPVAPVGVTDFPQGLFYIKSALNGKVLDVPGGSRKADTRIILWSQKHGQDRDNQLWFTIDNFIMNVGSRLCLDIRGSLTTDDLAQFAETRIIQYTRKSRVDAHNQRFGLSPEGYIYCLAHPNLVFDVRGHNESDGATLIIYPRKSDDKGGAAKNQRWICEPVSSPPQEHAPPERSRTSSLRRALTGSSLRDLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNF3</accession>
    <name>A0A8H7PNF3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_007803</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNF3"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12306">
        <property type="entry name" value="RRM_II_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF12">
        <property type="entry name" value="EUKARYOTIC INITIATION FACTOR 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="85"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2177146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="209" mass="22837" checksum="F71420D21D01B86F" modified="2022-01-19" version="1">MSEPEKATTVPQLTEDPVVQEKSTEETPAGDVENGAAGEDDPELAAMKARVEEMEQEAAKLRDMTAEVEKTMNGPEEDKEAVDSRSVYVGNVDYGTAPEELQAHFQSCGTINRVTIICDKFTGHPKGFAYVEFAEPEHVNAATALNESLFRGRLLKVTPKRTNIPGFSHRGRGRGRGGFRGAPYHGHMAGFGFRGRGGRGRGRGYYSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNL1</accession>
    <name>A0A8H7PNL1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNL1"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053135">
        <property type="entry name" value="AKR2_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43312">
        <property type="entry name" value="D-THREO-ALDOSE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43312:SF1">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="452" mass="51087" checksum="F1F0DFFB54CB1CAA" modified="2022-01-19" version="1">MIGKLGRQVSRLGFGAFRVNNDTHAEALRKALVSGVNVIDTAANFESGRKLGKNHRRDIEDHDKQERDIPRHYVQVRDKSYHSISPRVLEMQITQSLDRLNTDKLDLYMLNAPERMLMAQSRSYSASQLYKDIAAAFQHLDTEVANGRIRGYGVCSNTLADPTAVDHVSLPSVINACAKQDNLVAVETPFNFFERKAIVQPHGLTVADICEKHNLFLMTNRPLTAIHEGKIRPLVNRTFGDGSSQAEHAVMEQMSQSLEILTNMESDLMSELPLEQETLTAKFIWAQVISDNLSNLSNNHFAAKHFLEKMLLSTLGTDLKDLISYAEKLDNPEALPVFQQWAADYQKVCDLNIEELSQHLIDYAYIDCLRKNNDLDRIISAVCPRLTEPEKTYSPISVKMLRIALANKQIGCVLTGMRDPLYVEDAKKALAWHAQQPLDATDLEDLWRVPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PNZ2</accession>
    <name>A0A8H7PNZ2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">holo-[acyl-carrier-protein] synthase</fullName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_007822</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PNZ2"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055066">
        <property type="entry name" value="AASDHPPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF10">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22624">
        <property type="entry name" value="AASDHPPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase N-terminal" evidence="4">
        <location>
            <begin position="15"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="3">
        <location>
            <begin position="109"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2177165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="271" mass="31145" checksum="81EF521352D61299" modified="2022-01-19" version="1">MQPLVLLAVNIADWSSKELERGIPCLPAEEQQRVRRYRFEVDRCRSLASQLLRRYLFVKHSKIPWEQLAFETSEFGKPRLANEGFEDIDFNVSHHGDWVVLAACSQGKIGIDVTTRDIPSGSIQDFINCFNSQLADDEIQVLRKIEDMRRKLWLFYEIWCLKESYIKALGLGLHKDLKYVSFVSSKDDLTALRKVQVHDLQAPGNDPVYTFHLSYLDSQHPVAMCTNTDLSDAEDLLESTSLEVDQRQSNNPLTDTSFTKITLDEILQCTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PP96</accession>
    <name>A0A8H7PP96_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_002994</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PP96"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="280"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="688"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="688"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2177747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="805" mass="90149" checksum="4FA8A4870631107A" modified="2022-01-19" version="1">MYLHEAGHVGTLERRINRMEALLAAVDQHSEENSRGSPEQSSQSVTSSYTPHSDQQEEPVRASINNVARQNNLHTQKIPEEDLDLARFESVRYLGDLSAIKFLSKSFSLEDSMSSYLPGHHVERLGKDTFLCAANRVPDDPSDSNLQDYNTRSKWLKNYVGLDVTACDRLIALYFLNIHPIFPIVNKHTFLLRYRGQSKSYPSTIVFNAMLGAAARYLEISEHTSIPNTKDHRALSDVLFERVLKEVFLQSVSGPSLPMVQAIILLLNHHATLDSKGSECYLLSGIAIRMAQDLGLHQSCEEWTMPEAEKQTRKRIWWSLYIMDRFNSALFGKPLSIIDEDCDVSLPDENAPWREIADTYPKSADSRNNAVFPSMADTQNQKYEPKEDRPLYQMFLQLAKLSEIIGQILQGLYTTRAKQQSYIQGSDNLVTRLDHELTIWRFGLIKVLQETDTTQQNELNLTPVAESYKQGKPNPLSSYSSFRICTSAAERSLGLACNLSPSDFLRFSWHFNLYSVLHSGLMCVYNAKNPDARISTRAKSDLAKCVGLLKRVRNMSASAMKIDSLVHNMMKLQEVDITGYDSSEDSSAGDEVNETKHKKVAKLLNNVPTAAKSEPPVVDTIMESNRDQEMSQPSFQMDNVALNLLPNIGQNGAFDTDEAFTLKQFGLSKDNDFSYLKALDSITGDNDIWSSDGSSNQKPSLPDVSMPWNIDKNSNQVSSSIFQSGYLMSGIPSKPVGYAEEFPNLLSGGIPTGPAVAASENTLFRYTPNNPFWSIPASCDWDEWKSFYNQAAPSIPGNNPSAGVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPT2</accession>
    <name>A0A8H7PPT2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribulokinase/uridine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_003209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPT2"/>
    <dbReference type="OrthoDB" id="6362633at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2177962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19597" checksum="20EFF9D02D98F66A" modified="2022-01-19" version="1">MDGYHLPKAALDKFENPQEAHARRGAHFTFDPNGIVQLLKTIKDPANQNTIIKAPSFDHAKGDPVEDDIEIYPHHKIIIMEGIYLQLVSPEPWNQIPVSFDEMWFIEVDTELARLRTGQRHFAAGLEPSLEAGIQRFDRNDLLNVQFILANRDIRAQCIKSVQEKDTEAGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPY5</accession>
    <name>A0A8H7PPY5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPY5"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase AlkB-like" evidence="1">
        <location>
            <begin position="23"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2178037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="110" mass="12415" checksum="DC637FAF065793F6" modified="2022-01-19" version="1" fragment="single">MMEASESKTCSLNFSLCVDLHSTGEIKAHVDNVEYSGSVVAGLCLLSPAIMKLRHKDDPNNQLDVLLDPGTFYIQRDSVRYAFTHEITLDNSVWNGEQIDRGRRISLLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRB2</accession>
    <name>A0A8H7PRB2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_001693</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRB2"/>
    <dbReference type="OrthoDB" id="2284405at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000002">
        <property type="entry name" value="Serum response factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="52"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2178847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="253" mass="28504" checksum="7EC98C2E76E4007E" modified="2022-01-19" version="1">MNNLAQMPGEPKRTFRDTTQRGVAGKGQIPTMVNQTGLEEDSDDSDKPAKRSGRRKIKIEYIEDKNRRHITFSKRKAGIMKKAYELSTLTGTQVLLLVVSETGLVYTFTTVKLQPIVTKPEGKNLIQACLNAPDPQQDNPTGSEFSDRRGSSLPEPEQQDNVYPDERQQQKQEQATPQMSYSQAGYAPPPPQQISSGNGYPPYGMNPSYQQPYPGQVPYYGNQSYMPQTQPYWNDQPENLKDKNPAYGQPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRF6</accession>
    <name>A0A8H7PRF6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRF6"/>
    <dbReference type="OrthoDB" id="497927at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098:SF2">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="324"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2178144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="367" mass="41241" checksum="FCEDFBD852EFD305" modified="2022-01-19" version="1">MGTDDDDKGPILLSCGSLIIDDIVYEDGTEQKDVLGGAGVFAIYGARLWYKPPLSRQIGYTVQRGHDFVPEIQQELERLSISLNPQDHLDLYTPRGLNTFSSDDHRDFEYIHPVIRIFPRDFPPKWLLSGQIVHLICSAARAQEIVDEWHTLQRKYAIQYEASHVPKTMFMWEPLPWDCLPEKWEEFTRVMKLIDIVSPNHEEAAAVLGTTMADLIDTLGSEHKALDHLADRFLQAGIGESNKGCIAIRAGKRGALVARNDTPHWLVPAYWQSQDHSRVRDVTGAGNAFCGGFCVGYLLNKDIIDAALYGSVSASFTVEQVGVPKLNITHESWNDDLSPDGRLADLRCRISTHMPSSEQQWRSTGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRK6</accession>
    <name>A0A8H7PRK6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_001841</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRK6"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="89"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="374"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="409"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2178992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="431" mass="48314" checksum="E3B3091818AC6A03" modified="2022-01-19" version="1">MVLKQDYFVLHNPLFSSLYIYKKYQTIRMADSYAWIFIVGIVVFFLIIVVLLCFTRASGSQLFTSISANDPELGTEFVETPAMLETLSEDARLSYERAKAWQTAYPPESVATEITLSQYLTIQEKGVAAFEFEADMAETNAFISGRTEIQFFSGECCVQTNLPFPKNQDVYYFEAKMYEKPISTTVAVGVSTKPFPNWRMPGMLSGNSDQQRYHIYSPCQFAGWNKHSVGYFSHNGCKMFNNPFEGKSYGMPFNEGDVVGVGYRHRTGTVFFTRNGRKIEDAYSGLRWNLFPTIGANGPCQVHVNLGQRGFVFIEANVKKWGLAPMQGTLAPPPAYGSERGSILLQSGVPRTPIERSRSEDIPEDAPLIALDHTSHVPHSQPPEYSSLPNQNIIANRLAREERGHDSNDEVEDDDATSFDDSNDAGQQHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRM9</accession>
    <name>A0A8H7PRM9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Phosphoribosylaminoimidazole carboxylase</fullName>
            <ecNumber evidence="4 11">4.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_003229</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2</text>
            <dbReference type="Rhea" id="RHEA:10792"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="4 11"/>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRM9"/>
    <dbReference type="OrthoDB" id="15425at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000013">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000037">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016301">
        <property type="entry name" value="Ade2_fungi/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054350">
        <property type="entry name" value="PurT/PurK_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004679">
        <property type="entry name" value="PRK06019.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609:SF5">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609">
        <property type="entry name" value="PURINE BIOSYNTHESIS PROTEIN 6/7, PUR6/7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22660">
        <property type="entry name" value="RS_preATP-grasp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001340">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="109"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2177976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="558" mass="60237" checksum="6574E10956A3EEE5" modified="2022-01-19" version="1">MNSQKVGILGGGQLGRMMIEAASRLNLQVVILDKPADSPAKQIESTQKHIEGEFKDPVKIEELAKQVDVITIEIEHVNAQILADLEKKGSTIHPSPSTILTIQDKYAQKQHLAAKGIPLAEYVETPDRAAVVQAGQKFGYPLMLKSKTMAYDGKGNYVVKSEADIDPAMQALSKTPLYAEKWAPFVKELAVMVVRRANGEVRAYPVVETVHKNSICHLVIAPAQVDGVVAERAQKVAENAIKTFSGAGVFGVEMFMMEDGALLLNEIAPRPHNSGHYTIEACETSQYENHLRAILDMPLGSTKMKVPASIMVNILGESDDMQQCYKPCQEALAIDGATIHLYGKKECRAGRKMGHITVVGESMMQVQSRLRPILKAIEPEVERPLSISPLVGIIMGSDSDLPVMKVGAKILKDFGIPFELSIVSAHRTPQRMADYAHSAAKRGIKAIIAGAGGAAHLPGMVAAMTPLPVIGVPVKGSSLDGVDSLYSIVQMPRGVPVATVAINNSTNAALLAIRIIGAFVPGVLDQMDSYMKKMEAEVIGKVERLDNVVSVANGWEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRR3</accession>
    <name>A0A8H7PRR3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_001907</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the MSS1-MTO1 complex that catalyzes the 5-carboxymethylaminomethyluridine (cmnm(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRR3"/>
    <dbReference type="OrthoDB" id="3329at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070899">
        <property type="term" value="P:mitochondrial tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000082">
        <property type="entry name" value="protein MTO1 homolog, mitochondrial isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.570:FF:000001">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000002">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="entry name" value="GidA associated domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1800">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG/GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049312">
        <property type="entry name" value="GIDA_C_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047001">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00136">
        <property type="entry name" value="mnmG_gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21680">
        <property type="entry name" value="GIDA_C_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="SAM_GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01228">
        <property type="entry name" value="GIDA_assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain" evidence="6">
        <location>
            <begin position="588"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2179057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="672" mass="74320" checksum="86D0284DC740A395" modified="2022-01-19" version="1" fragment="single">SATISAKLPIQQFAVSRFRFLSTATDITPAKTDFDVVVIGGGHAGAEACAGAARAGARTLLITQNPDTIGEMSCNPSFGGIGKGILMREIDAMDGLCARVSDLSGIQFNILNKSRGPAVHGPRAQIDRKIYKRQMQDMLQNYPNLTILSGSVHDLIIKHGSLNVDMTSGNIGAEVGGVTLENGRNITASKVVITTGTFLGGEIHLGLKVWPAGRIDENPSLGLSNSLKTAGFQLARLKTADVNVNSGTPPRLDGKTINYTDLLVQNGDNPPVPFSYLHDTVPFADQQVQCHQTRTNLATHKVISDNFHQSIHIRETVKGPRYCPSIESKIQRFTQKESHIIWLEPEGFDTNLVYPNGISNTMPEDIQLQFLRTIKGLENVDMIRPAYGVEYDYVDPRELRSTLETKRIKGLYLAGQINGTTGYEEAAAQGIIAGVNAGLATQKREPLILDRADGYIGVLIDDLITKGVEEPYRVFTARAEYRLLLRADNADTRLTRKAHDCGIVSKERWERFSNSDKELEDALMAMENTSLSPEKWQKFGVSVNSDGVMRSALDLLRWPNISVQNFHEIIPELKHISPEIRRRVEIEGLYKPFIKRQALEVAALRRDEDIFLDVNMDYNSLNNLSNEIRQKLAVVRPETLGAAKRIEGMTPAAVFVLLKHAQRSSPRFAQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PS75</accession>
    <name>A0A8H7PS75_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PS75"/>
    <dbReference type="OrthoDB" id="2440909at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="37507" checksum="6EC992D5479BF635" modified="2022-01-19" version="1">MDILRPLLDDESGSGSGGSVNSDQATTTQAQQDTTTSDAKPTTTTDAPTTTTTTDPPTTTTTTSPPTTTTTTDPLPTTTTTTVDPTTPTTSIPPTTTTSTTSIPPTTVTSSITPTTTTTSNTLSQTTTISTTTSTTSLDNVPTTSNPPPISSYSTSFSLISYTSGDSVMVSTTAVITTVTPVPAGDGANSVSSSGPNAAVIGGAVGGVVVFAALVIAAWVLWIRRKRKQNAKNNDFFDDEDMSYERMYAPSPPPFGATAGGSSSKRASMAALSEGGSQGYRDSISSNRMSMPFDDQLDPRPLLMAEHRLSQPNSLSSLKDPYSVRQNQRLRVLVASGGAVVPSTSTTSSDEHKPDAVSSSPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PT89</accession>
    <name>A0A8H7PT89_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Lon protease homolog</fullName>
            <ecNumber evidence="6 11">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_003922</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6 9 10">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="6 11"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PT89"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000019">
        <property type="entry name" value="Lon protease homolog 2, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="ATP DEPENDENT LON PROTEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 9" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="14">
        <location>
            <begin position="9"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="13">
        <location>
            <begin position="684"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="58"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="active site" evidence="7 9">
        <location>
            <position position="776"/>
        </location>
    </feature>
    <feature type="active site" evidence="7 9">
        <location>
            <position position="819"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="417"/>
            <end position="424"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2180134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="891" mass="98692" checksum="02F39A9B8FF0F943" modified="2022-01-19" version="1">MSSTYPDSIPLVILENKVLLPSVVTKVTIRGREASTLTRKLQAWQDKRQEAYVGCTPLKTLTTNSSDSQAVDESPSEPSTAPQMPMPSSSSNSTSNGRNLANDLYSFGCLGRVIRVERVGFGGYAIFLEGLARFRVEQILQERPHVLAKVQHFVEEVDMATNVEDGDLANQIAAFRVLSKAFVNKMRDLQLPDPLIAQLSKLMDNSKPGVLANILVSVIETTYEEKLDYLSTTTLKARLIMTNEWMTRQLHVSEKRVLKISQQIHSNIEGKLSKKQREFYLRQQLNAIKNELGEKDAPETGDNAAGSEDEEMSELKRRLLAAMLPKDVEATAMRELKRLKKLHSASAEWSVARTYLDVVADLPWSKSTQDVLDISKARSQLEGDHFGLDTVKRRVLEYLSVIKVKGDLKAPILCFVGPPGVGKTSLGKSIATAMRREFHRISLGGVRDEADIRGHRRTYVGAMPGLIIHGMRKTGVNNPVILLGMFKCSYMIILSDILISYIFMVFLDEIDKTAQSSHYGDPSAALLEVLDPEQNNTFSDHYLNLPFDLSKVLFIATANSVDTIPAPLLDRMELIKIPGYTFEEKLHISRQHILPKQIKAHGLNLNQIDISDTVLLSLAENYTRESGVRNFERKIASVVRAKCVEWAELREAEDTKSYNGIIEECDLERILGLPPYEKEIAQREAVAGVITGLAYSGSGNGEILLIEASHMPGEGKLQLTGSLGDVIRESAQIALTWVKSHAYDLKLTESSKTNLVENRDVHIHFPAGAVAKDGPSAGVALATAIVSLFSERRVPPTTAMTGEISLSGRVLPVGGIKEKVLSAHRAGIKKIIIPARNRRDVTSDIPANIQNDIEFVFAKTICDVLDAALILDQRGIEIHAPWIANRFESHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PU77</accession>
    <name>A0A8H7PU77_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PU77"/>
    <dbReference type="OrthoDB" id="2354239at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="241" mass="27670" checksum="A7341EA8CD408FD4" modified="2022-01-19" version="1">MQQSTKMYHRLDSSSYAPYNVNIWIQLKDLILSIQGHMFWIYSALFCILEESNNSAQRSAELKNAPKSPLSSQSNTVQKKSSYHVKKLVVIKDSDSMDSRTNPNGIPTMYQHRNASVLSVSSRINSMKTKADSTIEPLQMGQQKSKDHWQNPFSNMIKRRKPRGSIHPLEPVRASASTPAFTTYSVIETERFKGATRRSSAPTLPRYDPRPSMHEERNGITRPPRWWRKMTSNGWVRRNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PWY1</accession>
    <name>A0A8H7PWY1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lysozyme</fullName>
            <ecNumber evidence="11">3.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_008916</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">This enzyme has both lysozyme (acetylmuramidase) and diacetylmuramidase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="11"/>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PWY1"/>
    <dbReference type="OrthoDB" id="6590422at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06412">
        <property type="entry name" value="GH25_CH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000060">
        <property type="entry name" value="Lysozyme M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008270">
        <property type="entry name" value="Glyco_hydro_25_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34135">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34135:SF2">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00953">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="6" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034117489" description="Lysozyme" evidence="12">
        <location>
            <begin position="21"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2181333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="228" mass="24332" checksum="FEE1AF544119CF31" modified="2022-01-19" version="1">MKYTLAALTLISSSATLVSALLKGQDVSAYQGSINWATQKADGSTFAYIKATEGTTYTNPDFTAQYNGAYNQGIIRGSYHFAHPDSSSGATQAKYFVAHGGGWSADGKTLPGALDIEYNPNGATCYGLSKSAMVSWIQDFSNTYHSATGRYPVIYSTTDWWTTCTGNSAAFGTNNPLWIARYASSAGTLPAGFPYYTFWQNADSGTLAGDQDYFNGDATQLAKFAKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXV5</accession>
    <name>A0A8H7PXV5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidate phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_007209</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lipin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXV5"/>
    <dbReference type="OrthoDB" id="4567at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000063">
        <property type="entry name" value="Nuclear elongation and deformation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031703">
        <property type="entry name" value="Lipin_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16876">
        <property type="entry name" value="Lipin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="7">
        <location>
            <begin position="773"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="298"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="650"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="975"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="662"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="673"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="698"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="996"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1015"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1038"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1054"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1086"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1102"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1151"/>
            <end position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2182282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1184" mass="131288" checksum="6CA0C0B1AB97B73A" modified="2022-01-19" version="1">MDYVGRLSNLLSSVSKVYNELNPATLSGAIDIVVVEQPNGDLACSPFHVRFGKLSLLMPQEKKVRITVNGEAVPFAMKVGDAGEAFFVFETDLEVPEEFQTSPLMSAASDDGRGDEEPPYLDIGASDERDQTIIDEEGNCHTDAGYVSAHSASGSEFEESDGEIEQQSFPAIPPELQSPKMIIEEQLDKVVTTMDPYPSAKPLEQSLAEEVDMEERRLEERRLKDQEASESNTSPKTEPRPSSPLPENTTYPMEDGSTLLERISGEAITTTTVTKETFIVRPADGDIKSFFMDVTHNHVNDDSTGNCESSEPGTSDDTVERPSQPKGEHETMILDMAGYKIEEEQDEAAEELEDNDHIKHRHRKLRHMDEETREELAGPSENETAENEQPVEQSIETPQRPAIGNRERSHSLPHKMEEPAKSSSNAKAVDIPGSVQDVEPKSDSEMDYGETPVKSKSPDSEWSWGWGSLPKRQDSRKDSTDGSTDVLSGDLNKLSVDESEKNQNQTVSLSSTTTQDNSALEEVRLKSGRTYRIEMSLCGSAALGTDPEQCKRVFREYQVSYDQFVHNPNILNDAHLVFKYEGRYYKHVGMQAPLFTSMLLLPQPLSAMSDEDSKLGPKVSDSRDSYSFGRGWRQWWSRSSVAEPLVANTDLEQGDDGSQSHVSEEEKADDKTAAAAASTSHAAAGQKTTFTKTTTTTSVGWSAQQPHNAEDGPIDQSTYHKNYAKTLRLTSDQLKQLRLKKGVNTISFSVKSSYQGTATCVAKIFYWNHNTQVVISDIDGTITKSDALGHVFTMIGRDWTHNGVAKLYTDIHNNGYQLLYLTSRAIGQADYTREYLKKVEQDRYQLPDGPVIMSPDRLFTSFHREVIMRKPEVFKMACLRDVQRLFTSSNPFYAGFGNRITDAMSYRSVNVPASRIFTIDPQGDIKLELLSGYKSSYIHLNDLVDQIFPPLSKALASEYNDWNFWKQPLPQIELPKLPDPIPSTSSSPKPRPITPNPSSIPTSPSMSAVPEPKPSRSLLRSFTSRSQDGAKDKHGLTSYKSSPSLFSQSSQSSSDDKKTNDKRKPSNPEDVTGDQQAPVAIENSESKNQGSNNSLEGDANVTGSSLSQSPSSTSGLMKQVITGRVGGLRDTISRTLSRDSRRSTPSNDDLHDNEELDNDTENDLNGIIDEDITDDIDMDNIPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXX5</accession>
    <name>A0A8H7PXX5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_006870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXX5"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2181945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="52584" checksum="63A9042C02DEB590" modified="2022-01-19" version="1">MTPDALHDEPSKSEERIEYASFTKAQERALVRKYDLRLLPFLSFMYLFSSLDRSSVGNAVLDNFEQDLGMTGNQLNTAITIFYVGFLTFQIPSNIMLKRYSAKVWLPFLMIVWGTIACCHAAAKNYAQLMVLRVLLGFFESGFFKSYIQATRIAIFWGSTTAAHAFAGVLAFGILQMRGIGGLAGWQWLFLIEGIPTVLVSIVAFFYLPADSSKCSWLTEDEKVLAEERLRLEGSGGHQSLGDLSSSNRQEAFAALKDWKVWLYMIIFFCGSVPNTSISNFLPTIVSGMGYSNKLDANLMSAPPYVCAVAVVILVAHSSDRFSDRAYHAIGGAVVCLVGYILLVSITGNSARYGAVCLSVAGVFVINPIVNAWLTGNIAPGMKKSVATAMAVSANNAAGLVGSNIYLKSDAPNYIRGHTVNLGFTALFIVLVLLLRFLLWRENNSRQKQLSDLEDRKVVEDDTRFGDRRLEFRYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PYC4</accession>
    <name>A0A8H7PYC4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PYC4"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="149"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2182493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="426" mass="49361" checksum="BA792DFFEF8141F3" modified="2022-01-19" version="1" fragment="single">NVENNHGSSHEETPEVLDSAHSPKFAFPTVKIEDTDLSKAVPRDRLTSQSAISVASSDTNFTAITSTTTTTSASNAANEHTLAHYSNNADPSRLSPHRSYTSNDPDSEIRTYYQQQPPQVPDLGGEMEKWYAMTDRYGFLQESTHQTGIDKIKEHEVERAQKWAKMAKSKEANGEVMHYFDWTPKYIFHCSLSSEYTKVSQIVGDVMRGEYNYWYSGSSLLLLILYKLVNVKHVIRTRTPDRFRYTTNHARPHCAPRKIWIWKTFTMLVHMFEKCNLHDLFIPGFPALVEAFYIQERLIEKHLPKVSKHMVIVFSLRDLDITSSSYSTRWYITLFTGGIVNYHTLLRIWDVMHMCGFDVLYYVAIALLKTVQTKILKGDFETNMELLGSIIPIDDDDKFMKLVRKLYERNVETKVVEKLRIEYRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZL2</accession>
    <name>A0A8H7PZL2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZL2"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2183357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="328" mass="35219" checksum="237D9B1C66885321" modified="2022-01-19" version="1">METAESQYVPYPYTIMKGVSRDSFKQYRTPTRAISSSLRTLTAPAAQPMPRPSPPRIHFAFNPDAAPLVLPTPELFSACGASTFSSSDPILGDAATTAPSNPLVPVPVMVLSSFLFSLLLLRLVFKSARRLRQSWPIITSIIRMVAASPLAVVMAALAVSPAVAAAASALSTVFAVTAAPSTTAAAASATALLLIWLQLMLVLLLLTTFSSQPTRKLAVHKRKLSPGSRSVRRKAEPARSPLGSSSSLLAQAHSSPVSLVPPCFVHPPPSISTAATPAETRIERNVFARTDAHSRDQDSEAFNLYLDLWLAVFKLENRFERPIHSNPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q008</accession>
    <name>A0A8H7Q008_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q008"/>
    <dbReference type="OrthoDB" id="2279810at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2183437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="194" mass="21182" checksum="B51157146877268D" modified="2022-01-19" version="1">MSSHAPHSHTAWTAVGFSIGFVGIVGLVVSLVALIPLSVYNISLTIVTLTALVEEYDEGSVLLPPPYRSIQIFLAGSLAFSVITIILLLATCWRNASQNDSHSRQRRSRGKRVGRRGSKASSVAESERSMSVSEEVEGQSWLLKTSFIGRLTTLMFIAQFCWAIFGGISNDYDEEESLADQNATEQTPLLAEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0N1</accession>
    <name>A0A8H7Q0N1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0N1"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="234"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2183208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="448" mass="50894" checksum="E6FDAA6E46660BBD" modified="2022-01-19" version="1">MPATVNVPGSKMIKKIMSMRLSTSQDDDDDDIFFSSSISISSSTNRRRVGTTQPSGLKTARSTPNLPQLAMEQTKAMPPLPVLHARSRPNSADSGNSQIAVSERKYPSLSYSATSESSSGSSEYYRRPRSVEDIVQWMDDRVLQVSTINPSPYDLTAKDTNTKVPSKRWNTVSNRTRFDDPYALQHTLQEQDRMIAQHYLLRTAFKGCGPETYMIVYKIFVDTFDVNVCLFDVQELSTLFPRSTFIGIDINEDYPKQVKPKNCHFRKCNVVGDLLPFPDNSIGFIFQRDLNWGLQASDWTSLIQEYNRVLKPGGWIELVEPDIETQQSAAKERTLHEKIVNMLSCRGQDPFVSRRLSSILATSGFRRVESRFQSLPLGWSGDIGKAYAHCYYQQLQALGGVIGSSTLEDTIQTIKMDWNEFHAYVNWHSAVAQKPWTTRRQDATYEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0Y2</accession>
    <name>A0A8H7Q0Y2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ARM repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_006305</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0Y2"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000237">
        <property type="entry name" value="Pumilio homolog 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF13">
        <property type="entry name" value="PUMILIO HOMOLOGY DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="9">
        <location>
            <begin position="448"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="470"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="506"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="542"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="579"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="615"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="651"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="720"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2183300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="843" mass="94023" checksum="89D7A18C5AED81DA" modified="2022-01-19" version="1">MESQALDHDLQRIQKFQAFDEQMKRLDLQQHQEDMDLLKSTTLGPISPPNNPSSKASPSSRSLPTSRRNSENEDDPDVLDFGNKLKLSDNEQSNVQFSLRKSPGRLLNKLPNRSMTADVSNLQHTGYKPVSNAGVNTSSHATSAFSGSFLFDDDDHQSKTASGMVPPYPDTYITQYGDNADNYPFAGHENYAMRQHPNSHGNRNVESLQRHPDWLGSDAVPQQQPITSLTSNISEDRMPTTSAQAAFYSRRPSAGLTNNRSFSQTSLDPFSEGFQIRSKLNTARSTTDLQSANSNASRLPANNGLVGYDNLTSDNTVDLSANICRQHLQGYCPRGEQCPYLHTAPSAMGFSPVPPVASAAGMPGSQHHVAMAAAAGQMGPMGYAGGVPINALYQQYPNGMTFDPNAAAQSTGLVHGFGKPGPHPGNLGNMRYQHQPGNLGHHKSDNNMYSRRGSADHDQNNRFANVELKDLTGKIYELCKDQHGCRYLQKKLEEQNEENLNTIFNEVFKHFVELMTDPFGNYLCQKLLDYCNDEQRTIIVETVAKDLVGISLNMHGTRAVQKMIESLSTSRQIRMIIVALTPNVVTLIKDLNGNHVIQKCLHRLSAADNQFIYDAVSRHCVEVATHRHGCCVLQRCIDHASISQRAQLVTEVTHHALPLVQDPFGNYVVQYVLDLGDAVFSDALIRRFVGNVCKLSVQKFSSNVIEKASEVETRQLLIEEMLDKDALEKLLRDSFANYVVQTSLDYADPEQRIKLVDCIRPILPSIRNTPYGKRIQGKLQRDQQQRDPQQQGNVFKKFGNMNNRDNVQMQNLQQNNGLPVLGFPFNYGNMGMIGMNEQMYPYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q163</accession>
    <name>A0A8H7Q163_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_006648</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q163"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000044">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="186"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2183640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="410" mass="45865" checksum="39862E1906AFD7DC" modified="2022-01-19" version="1" fragment="single">QTRLTLANFTITKSPVAIMAKEGVKQYYQAKIEECELTINEKTQNLRRLEAQRNALNAKVRLLREELQLLQEPGSYVGEVVKVMGKTKVLVKVHPEGKYVVDIGSDIDISTLTPTVRVALRNDSYQLHKVLPNKVDPLVSLMMVEKVPDSTYEMVGGLEKQIKEIKEVIELPVKHPELFESLGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCRFIRVSGSELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSARIESSGGGDSEVQRTMLELLNQLDGFEPTKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPSEIARADILKIHSRKMNLTRGINLRKIAEKMTGSSGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMKKDSDANTSLKKLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1P5</accession>
    <name>A0A8H7Q1P5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_006744</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1P5"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF26">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="6"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="185"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2183733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="316" mass="35145" checksum="FFD7681AE0ED9F9F" modified="2022-01-19" version="1">MSTHTVVVGAGAIGCVYGWRLSHNAEVMTVCRSNYDIVNQEGFAIDSEKWGEGVFRPARVFRTTEEAAQVEYDYVIVTMKALPDVYDVSEIIRPVVTVGKTSIVLIQNGLGVEEPILTAYPANPLLSVVAYIASSQTVPGKIKMMSAENLIMAEYRQPNVDGEQQKNRLHELFLKGDVSMKVVPDIEEPRWQKLILIAGIASTCVATNLDTSGVTTFAPSAELFRNVMRDIVAVADAYGYKYDKEKEVEIMFKRVASLNAYKPSMYLDFTRNQPMEVEVILGTALRRAKQKNVHVPYLETMYAVCSALNSNKQGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q1T5</accession>
    <name>A0A8H7Q1T5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_006505</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q1T5"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000053">
        <property type="entry name" value="BZIP transcription factor AtfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002112">
        <property type="entry name" value="Leuzip_Jun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021755">
        <property type="entry name" value="TF_Aft1_HRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020956">
        <property type="entry name" value="TF_Aft1_OSM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11786">
        <property type="entry name" value="Aft1_HRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11785">
        <property type="entry name" value="Aft1_OSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00043">
        <property type="entry name" value="LEUZIPPRJUN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="316"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="258"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2183499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="408" mass="44610" checksum="5298E9B43BE7BC7A" modified="2022-01-19" version="1">MIATNTTSIPFFDQRPHDKISLSNTNAVAVAAVSVLKQAVPEVTVVEPAMLQRPLEQQPVPVAVPAEELPENYATLPQNTKLDEEPNPFEKSFSDIPASATKAAIAAQQQAAKPVLPPVTAIESPSTGVPTLKKATNIDPYAWGSLRAGPLSPSMLQGPVNGNPVPFTATATAMSKVEPDEFVPYQPQIPTSMQYNFQANTINAPGSKFGVYQQPPAPPAVSKTSPAMQQMTTFPAQTYQTQPPTAKVEQRPFQSAEFIHHENGISSRKSSKSSSAGVSEPKPTTRVKRQEHGELMEGLGPVAKKNKSSTTEQDEDEKRRNFLERNRQAALKCRQRKKAWLNDLQIKVEDLAHENDQLTAQANAFREEIIHLRTLLLAHKDCQVSKDNGSMIRLALDKPLPPAILPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q224</accession>
    <name>A0A8H7Q224_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_000907</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q224"/>
    <dbReference type="OrthoDB" id="397265at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22385">
        <property type="entry name" value="KH-I_KHDC4_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22386">
        <property type="entry name" value="KH-I_KHDC4_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000037">
        <property type="entry name" value="KH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047890">
        <property type="entry name" value="KHDC4_KH-I_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047889">
        <property type="entry name" value="KHDC4_KH-I_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031121">
        <property type="entry name" value="RIK/BLOM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744">
        <property type="entry name" value="BLOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744:SF0">
        <property type="entry name" value="KH HOMOLOGY DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="ATP-dependent RNA helicase PRP5/DDX46/KHDC4 KH" evidence="4">
        <location>
            <begin position="79"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="KHDC4/BBP-like KH-domain type I" evidence="3">
        <location>
            <begin position="186"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2184994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="49946" checksum="CF3242BF331BA321" modified="2022-01-19" version="1" fragment="single">WDLDDQAATSPSKVSKTDDSHTENEASNHATTANPGKAKDADSAASEAAARINALLAQKGIDAKTGSETGEGPDGEFYKDIPINDIKNRYMLTRGATQTMIQQETGADVTTRGKYYPDKNLATERDPPLFLHITATTKEVLDAAVAKIQEMIDQGVMPTPPAPITRAPPQRTFLEHKVPVGIEGAPHFNIRAKIIGPQGSYVKHIQSETGARVQLKGRGSGFVESATGVEADEPLYMHITCARQDGLDKAAKLSEDLLKTVKDEWERFQQQPPQYGRGYGRGSYGHGPPQHHGNYGYQQYGAPPPPPVNPPLPPGPPPPPPSGAGPDHTSPPPPPPAGVSEHSASPAAPDASYGQYGSQSPATPATAGANGYPADAYAGYGQYDQYNQYGQYGQYNQYGQYSQYGQYDPYSQYDYSQYYATQPGATDGNASAATSQPPPTSTEASPSSAPPPPSDDQDYHAVPPPPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q231</accession>
    <name>A0A8H7Q231_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_000412</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q231"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052788">
        <property type="entry name" value="RING-type_E3_ligase_ATL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45798:SF97">
        <property type="entry name" value="ALCOHOL-SENSITIVE RING FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45798">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL61-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034183934" description="RING-type domain-containing protein" evidence="7">
        <location>
            <begin position="23"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="337"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2184503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="486" mass="52893" checksum="A49E0B080EDC8144" modified="2022-01-19" version="1">MFSRIKLLSAYLTLLSIPIVYGQTVANPVFQIQNWVGFTSTSITNDNLGLDEVAFSLQFQTINVGSDYNSADHECGTAATCGPRRYVVNLDYACNATFNATTLEAANGNVFAAAHNISHKAVGLISRGGNCNWTEKVTIAQSIAAATQLPLDAIIIYDNQRYTNYTDDLLDNTGPIQPPTYGELPADQNATTMFDNDLNVGALTMAVYFASNEFGQALAQNVSIASTNSMNNTNKQIWVWTPILGYSNDNSFSTMLAASKGYLSYIIGLAAIFLVGAILLRWWRIRRLREQMAQRGDLEPGIAMRNRHPKVHPLPVDILNTYPVESYSPEKIKNNSCAICLDDFLTDKNTVRVLPCRHGFCTGCIDPWLTDKSPYCPICKYDCLPAELREHANLVEQNPVLGSSSPFTTPSAAAAAALATDDESTNHSIHSAPPPPFEEHQPNTNEAESSEHAREASTLAATATPNNLQESNPSDSNPTDSKPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2H7</accession>
    <name>A0A8H7Q2H7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_006487</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2H7"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015227">
        <property type="term" value="F:O-acyl-L-carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902603">
        <property type="term" value="P:carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF4">
        <property type="entry name" value="CONGESTED-LIKE TRACHEA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="29"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="126"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="225"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2183481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="315" mass="33623" checksum="88A3B501E207C90C" modified="2022-01-19" version="1">MSTEATVIPTPINLKDQVQIEKKEVKQTTSSVKSFLSGGFGGIASVLVGQPFDLVKVRLQTTEGVYKSTLDCFTQTIKKDGILGLYRGMSTPLVGVTPIFAVSFWSYDMGKKLVYAATPNRENQQLSIAEITAAGAFSAAPTTLFMAPSERIKVLLQIQGQGGEQKYKGPVDVVRQLYKEGGVRSIFRGTGATLMRDAPGSAAYFACYELTKQALTPAGAKPEDLNPASVLFAGGMAGVAMWCIAIPPDVIKSRLQSAPAGTYTGALDVLRQTLKSDGPAALFRGLGPAMLRAFPANAATFLGVEYSLKAMNYLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2P3</accession>
    <name>A0A8H7Q2P3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NECAP PHear domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2P3"/>
    <dbReference type="OrthoDB" id="10265489at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13228">
        <property type="entry name" value="PHear_NECAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000150">
        <property type="entry name" value="Adaptin ear-binding coat-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012466">
        <property type="entry name" value="NECAP_PHear"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847">
        <property type="entry name" value="ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847:SF9">
        <property type="entry name" value="NECAP-LIKE PROTEIN CG9132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07933">
        <property type="entry name" value="DUF1681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NECAP PHear" evidence="2">
        <location>
            <begin position="5"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2185022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="204" mass="22797" checksum="B3763CD34A79E356" modified="2022-01-19" version="1">MDDDYESVLLIVRECYVYKIPPRTTARGYRAAEWGDMEAFLWKGRLRIIAQGKKCSIRLEDNNTGDVFAVCPYDPNDTSAVEPVLDSSRYFVLRIENEGRHAFVGMGFLERSEAFDFNVTLQDFVKQINAEKEAESKPKEDNTPKKDYSLKAGETISINIGKAGSRQSRPKADSTGSGSGGLVPLLPPPPSAAQVKRQNQKFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3B1</accession>
    <name>A0A8H7Q3B1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leo1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3B1"/>
    <dbReference type="OrthoDB" id="20844at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146">
        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2184530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="57429" checksum="2A6306D88CCB65B0" modified="2022-01-19" version="1">MYFNCYSVAAATATATAAATAAEITVLHVIRRAYAWPRGNSPMGGLVVTLNFTKRGSQSSQTQPVACNILAITSTKMDDLFGSDDDQQSELNDTPSPTEAHAQSNTRVGNEDESHSAAIDDLFGSDESDSEAKPARKRRVLSDNSESDQEAEEKLNENDMDAQEGDEEDDRAFKRQRIEVELTMPELPLPSSKDDKFHLAKLPKFLDIEPTPFNPETFDPSEEGEMPPPDIIRRQVESTMRWRQVVDENGKLATESNARLIEWEDGTMSLLLGSEYFDVNVKPMSNEEHHYLLAHQTSSGILESHLKFTNNMVFRPSDLKSDTHRNLTAQIADKHVKKTRTKMFMTEQDPELVKQEAEMAEQERLRAKRKLESSRRRAEDRYSYDRPLRYEYEDEEVGGAGGRDEYDEDFVVDDDIVEEEEEEKERRREERLSNLKKSGMDKYRRRGRADEDEDEEDDDDEEEEEEEEEEDDEADLTPEEEDRISSRKAKRRQVLSDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3G1</accession>
    <name>A0A8H7Q3G1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_002194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3G1"/>
    <dbReference type="OrthoDB" id="2327495at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2185759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="187" mass="21322" checksum="99834F6772F72274" modified="2022-01-19" version="1">MRRAHSRTTIENNKPFIDLTPKLVHYIQYGGFSDEETNRAAAIINIFVQHIVITHHGLALSWYLQRQLARLHEQYPITTLLQMSLTAATSQCQYQLMAIPSITTFLITNATTCPEIPLSDSFIFNIFGALDSIILSTDYAKHRKILIDAMGRVVFEMPIRGPLGRQMRQRYESLNNQVNPAVPLLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3I9</accession>
    <name>A0A8H7Q3I9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_000798</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3I9"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050648">
        <property type="entry name" value="F-box_LRR-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382:SF67">
        <property type="entry name" value="SCF E3 UBIQUITIN LIGASE COMPLEX F-BOX PROTEIN POF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="55"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="4">
        <location>
            <begin position="128"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="4">
        <location>
            <begin position="227"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2184885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="590" mass="66002" checksum="46AF64FC1E6885E5" modified="2022-01-19" version="1">MLPFAHTPDRNNSPSPTNFGSAPSSASSSVTSLSSNVDMDKPLISMDSASPAYAQSLPSEIIYSILKQVASMSDVYSCSLVCKAWCYMALEVLWFKPGFQSTKTLSRFCSLLRQDPSTMTFLYPSMIRRLNLSNLSEDIDDPVISCLATCNRLERITLAGCTRLTDNGILSLLQLSVGQNLISVDLSDMTNVTDTAILAIAEKCPKLQGLNLSMCKDSQERSDSVQIHDESIIRIAERCPSLRRIKLSNCVHLTDRSAIALATHCKVLLEIDLMNCNLITNAALVAIFRHCSELREFRINQCKNISDTAFTQSVLASKPAGVFHQLRILDLTSVNSITDQSVAVIVQAAPKIRNLILNKCDNITDESVFSICKLGRHLHYLHLGHCDKLTDRSIIQLAHHCMRIRYLDLACCVQLTDRAVMELAILPKLKRIGLVKCQNITDDAIFSLTNLSRMTNSLERVHLSYCVKLTEHSITHLVSSCQRLTHLSLTGVQPFLRRDFQHFCRPPPRDFNDQQRSLFCVFSGKGVRDLRAYFNRLRLLHGDIAGAESHTLQDFHRPMLQSLQNDTVYMEVDGDVDGDGDNDIEDMEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3Y5</accession>
    <name>A0A8H7Q3Y5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enhancer of translation termination 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_001008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3Y5"/>
    <dbReference type="OrthoDB" id="5573535at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2185095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="44047" checksum="58AB7635A6F71E43" modified="2022-01-19" version="1">MKRAANTLDNEGTSKRVKVVKKDRINHASDCSDPQCEGCDVGEVELAFTNEDGSAAETPSALELFHMAMDEAASEGSKSNENGMAKKIFDLALEAYEKEKDQDPLGYAQCLIEFGRYFDVIESVKEGVDNLRGLEKSPKKEEPPISTNELHIAKGRGILVQLNIERAKRIEIFEEIREEDSDEDDDIDPAVLKKLEVTKDEKKLINEAIQSFDKVFKTKTDEDYEKHILLCCNDLRRYGEQLDLPIYKETVNLVLTTAMSYIKSLKDVESNAFALKIWGASLFYEARADYEADNAQQLVETALQKLLAAKTLETDDHDLETTELIGHCKMLLSTISTDEDEVIRHYQEAIDSFKAVVERSNDPDPKLLELIEMLDGGDEEEEEELDDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q404</accession>
    <name>A0A8H7Q404_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Oxidized purine nucleoside triphosphate hydrolase</fullName>
            <ecNumber evidence="11">3.6.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">2-hydroxy-dATP diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">7,8-dihydro-8-oxoguanine triphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">8-oxo-dGTPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Methylated purine nucleoside triphosphate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoside diphosphate-linked moiety X motif 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">INT43_000818</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Also has a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. Through this antimutagenic activity protects cells from oxidative stress.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2-oxo-ATP + H2O = 2-oxo-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67392"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71395"/>
            <dbReference type="ChEBI" id="CHEBI:172878"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67393"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-oxo-dATP + H2O = 2-oxo-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31583"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:63212"/>
            <dbReference type="ChEBI" id="CHEBI:77897"/>
            <dbReference type="EC" id="3.6.1.56"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:31584"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>8-oxo-dATP + H2O = 8-oxo-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:65396"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71361"/>
            <dbReference type="ChEBI" id="CHEBI:172871"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:65397"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31575"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:63224"/>
            <dbReference type="ChEBI" id="CHEBI:77896"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:31576"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N(6)-methyl-ATP + H2O = N(6)-methyl-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67608"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:144842"/>
            <dbReference type="ChEBI" id="CHEBI:172873"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:67609"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>N(6)-methyl-dATP + H2O = N(6)-methyl-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:169976"/>
            <dbReference type="ChEBI" id="CHEBI:172872"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:67605"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>O(6)-methyl-dGTP + H2O = O(6)-methyl-dGMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67600"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:169974"/>
            <dbReference type="ChEBI" id="CHEBI:169975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:67601"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.56" evidence="11"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q404"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008413">
        <property type="term" value="F:8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008828">
        <property type="term" value="F:dATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042262">
        <property type="term" value="P:DNA protection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03427">
        <property type="entry name" value="NUDIX_MTH1_Nudt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003563">
        <property type="entry name" value="8ODP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43758">
        <property type="entry name" value="7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43758:SF2">
        <property type="entry name" value="OXIDIZED PURINE NUCLEOSIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01403">
        <property type="entry name" value="8OXTPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="22">
        <location>
            <begin position="6"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="23">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00053094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAG2184905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="168" mass="19413" checksum="5EB3000D85F8CD5A" modified="2022-01-19" version="1" fragment="single">MQNITSKKQLTLIFVIDEQEQKILLGMKKRGFGCGRYNGFGGKVEKGETILQGAHRELEEEAYVTTDKLDRVGLILFTFTNDPVALEVHVYATNSYHGEPKESEEMKPEWFLYNDIPYDTMWPDDRIWLPILLNGKRFTGKFHIAENQTTILSQAVTIAETELPEQWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4H6</accession>
    <name>A0A8H7Q4H6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_000807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4H6"/>
    <dbReference type="OrthoDB" id="16851at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2184894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="319" mass="36508" checksum="A51F440E7299EE30" modified="2022-01-19" version="1">MKVEDLVRIKACNSSKYSRSYYQQHFEVISSKLLSEYVLCIGKSDQYRLLEVEAYLYEDEFHNDPFTHNHPKQRVPGRWFFHHVGMSAGFRGGTRKGMDITMGNGQNECKGGFLIRAIQHITSGTVIDGPCLLVDNILKILKMSNIKDLVDTYFKETKGSAGDKCSGFWLEHLPSPASELEQKRKLDHQTPQIYRSIRIGLGMKAKQDYLHRLDYVGRPYRFVLRPHLLQKGKLWLALELLENSALSIDEIADVLNMKSSIIEGYQTAFLEGKTNPKSTLKSCIQSKDMASGNSEWKCKALGAIRFWEQQDDDNKNLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q4H9</accession>
    <name>A0A8H7Q4H9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Senescence domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q4H9"/>
    <dbReference type="OrthoDB" id="20821at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009686">
        <property type="entry name" value="Senescence/spartin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045036">
        <property type="entry name" value="Spartin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068:SF43">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06911">
        <property type="entry name" value="Senescence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Senescence" evidence="2">
        <location>
            <begin position="87"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2185792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="438" mass="47043" checksum="4F581457543722B5" modified="2022-01-19" version="1">MSMKNTLAVVDPADGHVTSIVAENVTMDIPDVPPNEKKDKSDAEVAEEWDKEAGHVAPVVIDGSEEELMRNPKAIRKVVLIDKAENALINGSGRIADNMVRGGYALASRISRGSRGLENQIKPSDNPVTISDDTRIAIEKVGDTTASISKGAAKALDRAISATMKGVTTLYEHTKEPEDEKSVPKNEPPSDAKRLGQSALKAIATVLHGTGIAAGAVGDSARVAMVDLIRRKYGPDAGYVAARTLHVTGNLVGMLVYFDARGISRQVIVRGTKSIHPYNQQKKEDYSDTDSSGDEDDKPKLRSSMTFPVGAPPPYPPRPGRSRSVDDNKIPAFPSSIPPPYPPRPTTSSKPTVKADENFGNEKEALAKAYDTQDIENDAPNASDVRQLEVPCAPPAYDLDSKETSKSMQDVPASTEASAPDIKTKQDLETPDQNVNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q541</accession>
    <name>A0A8H7Q541_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_002419</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q541"/>
    <dbReference type="OrthoDB" id="271862at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22453">
        <property type="entry name" value="KH-I_MUG60_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056553">
        <property type="entry name" value="KH_Mug60-KHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF76">
        <property type="entry name" value="KH DOMAIN-CONTAINING PROTEIN YLL032C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24563">
        <property type="entry name" value="KH_Mug60-KHD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="171"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="421"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="489"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="574"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="683"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="962"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="703"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="983"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1023"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1085"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1112"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1124"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2185981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1141" mass="125831" checksum="DA3320DC7EC6C30A" modified="2022-01-19" version="1">MVQLAYSLCFAPPASSHYRPVQIPVQILQSHCNVVSTRYGCQTTLTPLDPLSVKRQSLNCDYNLTIHGPAAQVTATRGELLRDNPLQVVATVKTRRSDLYAESGAIKDNVHPLVDQISKDTNTTVNVEIVGHELPSGLQSENGAHIIIQGSPEATEQARIQTLIMLDELAGLRTDTINIPARLHNLVCGRKRCYIQSIMEETSTNIYLPSAFSNVNHPESSAQDEQSAIIYITGTSSSITRAKEMLSKLYVQKTKSMYQKDSILHPRKADWLLMHRRDDLLAIMEDNASYILFSAPGSGNNMITVFAESRVNAERTLRALNHLHNPIQYAYNPIYRKQACNVYEATFYFFARNGSMYSEGPNFFNSMSNLTGLVLQLSQISGAEVAYKTESGSIEVIGSERAIRNVYQRLNDMSLLKVYHHDTIFNVELSNEQREFISGKKSGKINKIMKTSGVKIKFLPFSEYNFVIEVQSTSFVKALDGLTLLQEELPAEISFYVPEAYHKRIIGVGGKNIQRIMKKYGVYVKFSNAEEFAALGGYYDNDDNVVARTPMKNQINLDNLRHAVMELISSKDKDYTSKIISIPIQYHRTIVMEYAQEIHDIEQKTNTRVRWPKRELSSESVVLYGPESQLAIASQLLSALISEEYYLRVPYSPALLLVVESEEFNEKVIDRIKSEYNITVDAGHQNPIELEPSTSTGNKRSSSRTSLSRSDATPVSSPETPTSSSAIVQSDLDRQDYVFTLKFKRNVIDNVTSALSILKSYLHSCKITTYPESTPMERPKSDSYAGAFAAFNSKILGGVPSTSSTTANANSHPADMGVPSSAFSTYSLFDYPSSNAFDTHWKPIRDSTSSSPDNLRAIFDNMTMDKPSGLMPQQNHSTPVRNTNLSFGRTLPMPSSAQVADIWNQGPIGTAGNPAVPPPTMHTSFSGPMDTTLPMLGNYPPPNSASFDLPSTRNLYPLQYSGAGGGGVDENGNVHELNHVHPTASSSTDTTSSMTSSRSMPEVIMERESKPPPISNSAGFVVRPPTSSSSTPMRSKSWFVTPGQQGATPPPPMRPSSSGSAAFQSNPAANPALFSYLGGQDNHHVGQQQQHRSSPTEDSNQRSSWNTHNSTAPGNANNGWANATSNEQSESPNEWSFVPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q696</accession>
    <name>A0A8H7Q696_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="3">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002763</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q696"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000026">
        <property type="entry name" value="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="7">
        <location>
            <begin position="36"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2186325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="461" mass="52128" checksum="5996A5DE15BBF80A" modified="2022-01-19" version="1">MSLNRVLWPTQISTATVAEDGTLQPNVIHGKTLGLRSFILNRPYRLNALNLSMIRNIYPQLQAWEQSDNCKLIVMKGAGKNEFCAGDDVRDVLAQVKKQDPDALHFYKEEYDLIHYISMLKTPYVAVMNGHSLGAALGISAHAPFRIATENTIFAIPEAGLGLFPAAGASFFLPRLDGQIGTYLALTGKRLEGIQAFYAGVATHYVPANRLEQLEDRLSDMETSDHEVINMVIEEYATLTDTKAIGFDPEIRQIIDRCFRFDTVEAIIDALDKEKPTSFTRESKSKLLHYSPTSLRVILRLLRIGAKMSLGECLKMEYDLVQKFLATPDFWEGVDTMLVKKARQRKPQWQPAALSEISSETIDERYFSYPSPNALHLQSSLDFREYPYQRYSLPSEAEVKAAILGESPEFRKTGGIASTEEAVKWFKTERRKKKGVEEKVRDILSRKTIIFDGKLCWQASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U762</accession>
    <name>A0A8H7U762_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_004630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U762"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170034">
        <property type="term" value="P:L-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170038">
        <property type="term" value="P:proteinogenic amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="6">
        <location>
            <begin position="83"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="7">
        <location>
            <begin position="532"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="655"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2173256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="675" mass="73702" checksum="7ECFDD70D3CF7840" modified="2022-01-19" version="1">MTRPLTLVEKILAHHAMGEAEVAPGNMICVKVDWTMASEASWASMYKTYKKLGSPGAYRSDRIWLAADHIVDPRINHLPKPAAMIAAAEAGVKELDIKDYQPPNTTIMHTEFYRERAQPGMLIIGADSHTCSSGGLGAVAVGLGAADVVFPLVTGETFFQVPEVVKIEFIGKPNVGIGGKDIILHILGEFKRNTIAAGRAVEYCGEGLQYLSCDARFAISNMSTEFGGIAGVFVPDQQTAAFIERRNSNAHKDEALYFRPDSDAQYVETHVVNLAEIESKIALYPSPDNVVDVKDKEGMKFDGMFIGACTTAEEDLIVGALVLQQGLKNGYELAPAKKRKVTPGSIQIIAKLRSLGLLQVYSDAGFEIGVPGCSYCVGMGADQAGEGEVWLSSQNRNFKNRMGKGSIANISSAATVAASSFSMTLKDPRPLLDQIDKDYFNSIRMYWVDHQKSIMYTEPKQNFSKFTESEAYEEEASVLPKSIKSRVQIFGDDVDTDAIIPIDKCTVESEEELGKGAFAYTRPEFVPRVAQGFDIIVAGRGFGSGSSREEAPRALKACGVKAIIAKSYAYIYSRNQANYSLFGVIVEDEKFYADATEECEIEILIPERKVVLNGKQYTFKLDVIEEKLQASGGIAARWKRHGKNLFRKLQQEASASGCGSNSNTSACSTNDVTAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U772</accession>
    <name>A0A8H7U772_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U772"/>
    <dbReference type="OrthoDB" id="2401014at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="15"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2173361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="143" mass="16998" checksum="1597390E0D48140D" modified="2022-01-19" version="1">MSQNGDSISSDDESHIPEHILEFKWKRKGRFYRVKWLNADEDSYTWEDAEDVEPMYPMLVSQFWERLDTRWPGKVQADDMGYFAQDSEGYNSSQDEDFEAQSASEEDDDDEESEDRSVDWRTVRSIEGMDKTLDGKIRVYVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7K6</accession>
    <name>A0A8H7U7K6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Wbp11/ELF5/Saf1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_004344</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7K6"/>
    <dbReference type="OrthoDB" id="205569at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019007">
        <property type="entry name" value="Wbp11/ELF5/Saf1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09429">
        <property type="entry name" value="Wbp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wbp11/ELF5/Saf1 N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2174321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="423" mass="46149" checksum="EBE9C8E9794B58CB" modified="2022-01-19" version="1">MAVVHRDTSKIEREIERLQELASQRQLDKNGQEKLKKLKEELDTTVKAKEAAGIKPDSTTASTAQEESRKLVFDAKKGAFVPMSKKKQQSMCHIIVQLEFGNAVYMSLFVGLEAKKAKRDQNGDSDGSDGATDSEDESEDESDNELLPELPVFKGEDLMEEEEAAAKASQKVEGANDSEMAKDKEVFDDEAKEDVSMPNAADSEEDSDIESIPMPEGPPPPKPFERQIPQAHQGNLARPPPPPPGGPGRHYRPPPSGGFRPPPPPPRPHHARPSHPMHYRPPTNVSMRRPPPPPAQSIVQLPVEAYAPAEVYAPAEPTELVDTVTATAPVTISAAPQVRDLQKELVGFVPAAVRKKQLQAGKKGAIPKVVRPNINAAPDMDDQDAVVSSALSPHLPEKPTSSEPSAKPGDEYERFMREMEGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U891</accession>
    <name>A0A8H7U891_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BD-FAE-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U891"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="2">
        <location>
            <begin position="15"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2175566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="245" mass="27401" checksum="780406D31F2B6AB7" modified="2022-01-19" version="1" fragment="single">YSTKPTGSKDMERELDVYFPSTGTETSPVLLFVHGGAWRTGDKAEHSWLAENLAKQGFTVAVNNYRLSHKTENNGEPIIQHPTHIVDTMEAIEYLKSEYPGRKLFLVGHSAGAHIILSIALKPQFQVKNIDGFVGVEGIYDIPLLLDTFPDYVDFIQQAFGKDSSKYKEASVVDFKPAPVTSPISLLYSPEDELVDPGQHESMEKFLRSESIPVAVNTDLLDKHDECLKTVKLIELIKGFVQQHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8P3</accession>
    <name>A0A8H7U8P3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">CCR4-NOT transcription complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_005475</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8P3"/>
    <dbReference type="OrthoDB" id="1923159at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16618">
        <property type="entry name" value="mRING-HC-C4C4_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12438">
        <property type="entry name" value="RRM_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000006">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034261">
        <property type="entry name" value="CNOT4_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039780">
        <property type="entry name" value="Mot2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039515">
        <property type="entry name" value="NOT4_mRING-HC-C4C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14570">
        <property type="entry name" value="zf-RING_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="9"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="104"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="238"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="290"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="364"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2176241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="756" mass="83280" checksum="114A28ECEE5415F5" modified="2022-01-19" version="1">MSDVEDYDCPLCMEELDLSDRNFRPCPCGYQICRFCWHHIRENLNGRCPACRRVYSEQTVEFTPISTDEIQRIKKEKKEKERQQREMEQANRRHLENTRVVQKNLVYVIGLNPKYANEETIMSNDFFGQYGKISKIVINKRPPPPSVAARHGAAALPSVGVYVTYARKEDAARAITAVDGSIMGGRILRASYGTTKYCSYYLRNMACQNPVCMYLHDLGEDADSFSKEELALGKQNLRDQMSTEVDSKPQVLGQHTGPPTSADFPPMSSSYQGGRRPATLESVAHIQFKNKGDKYQRGSSPSTESFEDVSAANSDEEKVDEKSALPATVSWATGSGPSTPKLKSTQLALTPDNFGPSLAAAAASAKLQSQLKPPGTKKRKEKVRSPSANSTADEERSLSDGHVPQLVPDSGEEAENDNEEDFELAGFAQYVLGNAFRSSNAAPRLSRFNESADDDLEEEVVGVQALRDEPTQELEPVQDGFKDTLPITPFAILKTSISPYSETGYNGPFDPFAPDEVVDEQPLARDTLRQSISELRKSPTVHMAPLQNFNDPTGDLPMQRSPATNGMLPPQMAAFNSPPMGNQFTQPMSPQRQAPRATNTLIDELMRRQEPYMRSRPPGISPNHVETTFNKLSPQASMHLSILNNAMPSVPPEMKTQPAVSQPAIPNGVPMMNTQGKPMGSGIFQDSAILSMGNLAPTPQYNEDNQAPEGRRLRVFQGMRNTEPAFTQPVANNSNDIRAGLAALLNGANYPGKLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8S9</accession>
    <name>A0A8H7U8S9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Triacylglycerol lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_005125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8S9"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF5">
        <property type="entry name" value="LIP-DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR029171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2173705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="44470" checksum="9C717CD8F28C7947" modified="2022-01-19" version="1">MRRAMLTPANDPFYAPPSGYENSPPGTVLRTRPVPNKLAAFATFPQNMANAWQILYRSTDALGNPEATVTTVMQPHNGDPSKLLSYQTAEDSAYSACAPSYVLQTGSGLGGLVTQAELLLMDAALGQGWYVSTPDYEGPKSAFTAGIQAGQATLDSIRAVLATTNVTNVHANASVALWGYSGGALASGWAAELQPTYAPDLKLLGAAMGGTPSELNATLNAINKGVFAGIAPAGIVGLCNVYPDLMNYILQNIIPSKKDQFFKAGSQCLAADALTYAFQDIFSYFTNPNILQGEVAVNVLEINKMGKYVPKIPLYMYHSLNDEIVPFNPTQALVTKYCSEGASIEFVKDIASEHGILAVTGAGDALLWLQARFNGTPAKTGCSSRTTLSSALDPGALPVFGKVIFELLADLLGQPIGPGSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U997</accession>
    <name>A0A8H7U997_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sister chromatid cohesion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_004448</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SCC2/Nipped-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="418242at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23958">
        <property type="entry name" value="SCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026003">
        <property type="entry name" value="Cohesin_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024986">
        <property type="entry name" value="Nipped-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12765">
        <property type="entry name" value="Cohesin_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12830">
        <property type="entry name" value="Nipped-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Sister chromatid cohesion C-terminal" evidence="8">
        <location>
            <begin position="1536"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1865"/>
            <end position="1901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2174425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1913" mass="217824" checksum="8E783430B6DD362D" modified="2022-01-19" version="1">MQSIFQRINFLTGLNVALSWIPPVTLDRQEQSYTTEPHYNELKISLHQGQPQSTKLNDFHKQLFELRAKIEDKPLSSFYNEQNEVGENEADLVNKNVKYSESQDFRLSNSISDHKHIEYITEQDESMVEDQLVFAVVDDEQMPDVITRNSQDQHDMESETQNLGVAANPNTNLSDMALAPAVAPMDIDQTFEVTVEGKETAEKYTELTNSNDNPEVGQHEDDHGTIKPAQLAIPTEKTAPEEVVTNTCSSDSALDRHTLNNVNSMLNHEQVVDESAIYSDATMKYTAFENVENHESDDYNHMRAISEVVDNPNAAENVLQEALLTETDNAIQSEEVQLDAASGLDNCTNDELQDSSLKHSLVSDFEQDVQEQVHDDPRSNHLANPDSSLPNDSKTVMTWSEEKDVVLSNLRHFIQALLHLENQMLLPTNMETDRGVGLNVGLSDADKGLFIVENQQLLLSPTTTRRIAALVRKANKYNQLKNVDDEELSWVLKKLEQNVRKGLLEIQDERRSSQESYGTPQLGGLDMLNIDRGADGAFTIFSILISTQLDKKLYAEEVIKSCLQFIKSLVNDIVSPLFETWNSTGKIRQRICDHILNIQFDTIALPAVYQQQGVAEFSQYSRRLQWIKSISLQAARIINQLCRFVQQEDISDDMVITICYISIPPFFLHSEHTIETSETFSMHQAHNSERPIVAIKVSSLDLLRCIFAKYAKHRNWILEEILANVVHMSSESEKENSYRTSGGHTVHVISALIFQLAQCSADSQRTKERSWTQKWELKNQRRIKGAPKLDASFINKVLATSAAGIEACTQTLHIFMVQLLKKSLKSPSQTNTTLEYRRILDVFISDAMKILNEPEWPVAETIIRMFSTVLMESLDNDTSDMSQRTLAIEYLGLIAGRIFRPIIETSVVSDSLNESMTMEDVHAITSIIEKDSLQNLNQLHTSQENHLVILEYLRNQITLDNIAQSALRYNILQWEYANASAWKSITESNQEENQELENRQSTLDALNSHIKQLWDILLDNNISDTLQDKSYQAMILRIFASLDSESVSQRSAALRALLNLSAKDISFMQKNHVHHSIIRRMQDTSPSVRDSAIKLAGNYLASHTEGTQQYYTAISERILDTSISVRKRVIRILRDIYLHTNIFSMHVDIGAKVIDRMIDDITAVRESALKASMETIFAPWTSPCIQRRNLEQTEFQYLPHDFKKEKAKVTVQASNAYCSWYAVDISDEKRLANINSMLKLIIDSLFSMLLQFEDAGDNSSVTNCIGLIHCFAKSSPHLFKRTLMTMLEPYLKSSNGTDNKALYYAIKIHDAVLPVMKRPDPLFLADTQLTLTKLLVDCPVLLLPQVTKSPKLGKLREEKGSVLNSGPVSSAQRLIRLCLITGLLCQYCDFDRKPELKDKSGRLLKLCQNGIAHETFDLLYFFAANRVTGDNISSQVSNQIKLAALQSLGYLYIQYPKFMVTKKSTTMMDEMFASRFNDYKSRVLHVFLDYLAGEEKRITEREKESSKSTSEVDVHKLLGDASEMAELRQVVILYVSSSLMQRYLDRILHTALDPNEQLRTLSFKVIVQIVQQGLAHPVICMPVIVALETSPDQLMRDKAYQLHNQLHQRHQGLLYSRNIACVETAYDYNARQLGKGSVVSGHLEEIFEYEALLQPMYSLLRDKRKARNDFLSSIVKLFDIDFSESTDKDIYFFRFIAHNLIGMRYKFVEELLCIIFAINKVLSTTAMNIMSALSIEDEIQDLDFATTSHSDRSRRTKRRNELKLATEGVLELDESLTVKYCLIMSLLLLIKHVLKQTYNLTEEKCQQYHPEESNSYKSKAVAQQSAVVAFNQSLLQFPIFDTETNSDVLRELACKHFAKLMMDDSLGTSNTENDKPNRTNQLDHQSSDDNQAEDDTQNRDDSIDLIDIIKRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9B7</accession>
    <name>A0A8H7U9B7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9B7"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034638456" evidence="2">
        <location>
            <begin position="20"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="256" mass="28790" checksum="D378B8E4CED0AE9E" modified="2022-01-19" version="1">MHTKIISLAILLSAVALQAAPLGKSDEDIAISRREEPHEDAKTRAQWAPGGLKAREEPHEEAKLRSEWLPGGLKSRDEPHEEAKLRSEWLPGGLKAREEPHEEAKLRSEWLPGGLKAREEPHEEAKTRAQWAPGGLKAREEPHEEPHEEAKTRAQWAPGGLKAREEPHEEAKTRAQWAPGGLKAREEPHEEPHEEAKTRAQWAPGGLKAREEPHEEAKTRSQWKAGGLKAREEPHEEAKLRSEWLPGGLKAREETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9G2</accession>
    <name>A0A8H7U9G2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_008078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9G2"/>
    <dbReference type="OrthoDB" id="79687at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14011">
        <property type="entry name" value="PK_SCY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF6">
        <property type="entry name" value="SCY1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="668"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="715"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="851"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2171698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="872" mass="97325" checksum="8BDD11D4EEB26C0A" modified="2022-01-19" version="1">MSSALYSFISSITNNITSRYDVKSQIASAGLWKIYSANRKTTGQQVAIFVSFFRIFEKRSLESGMRRDRGSSRADTERVYEMLKKEASNLTRLRHPAILEVVEPVSESRSSIAFATEPLQASLHNLLGNTDGFDGSTPKEITGFELDDLEIQKGLLQVGKGLQFLNNDAKVVHRNLVPEAIFVNAKGDWKIGGLGFSVFLNNPDRPTDSFDDFNDYMPDYCQLNLDYAAPEFVLDNDISVTNDAFALGCLAYTVHNKGKSLLETFNNLRKYQRMMEGLSAITYENIPNHLQEVLRHLIVREPSRRMTTIEFQSSKYFDNILVSTMKYLESFPEKSKEEKSQFMKGLSRVLGQFPDRVLTRKILPSLLEELKDHSLLPFTLPNIFSITEKLTQEEFCERVLPSLKPIFTIRDPPQNMIVLLEKLDIFQKKTPRETFRDDVMPLIYAALETPVPVVQEKALRIIPVLAESLDYTTVKNSLFPRVQSLFVTTTVLSVKVSTLICFHAMIKVIDKFTMQEKLVPLLKGIKTKEPAVMLVTLAVYDEMGKHLDKEIIATEILPQLWRMSFGPLLTLEQFQKFMKTIRELTTRVEEAHSKHLREVKQLEDQTRRITSEHAAIVSGTPAPANGGYDFESLVSGSKSVPQQAAVSADIFGDMNSNGSSTPSMFPVSAPSPSPLSYSPLPMNQSIPSQQSLYSTSGNSSPSYQGHLSPTSFSAMPPMQSSMHSSMQPTMHTSMQSSMHTTTLQPMNSNSYNQPSSPMSSSVNQVPKPAIDWSVNKKIPALQPPSSGNSFTQGYGKPAISPQTTPTPNYSAMQNLSLSSTSGMLQPQQSSVRPNNMLQPLAPIGSLNNMRTNSMKSSTNKKSSDLDLFDPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAA8</accession>
    <name>A0A8H7UAA8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003414</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAA8"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2178161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="273" mass="30862" checksum="656D268F6048C198" modified="2022-01-19" version="1">MSVISPIYSHDWEDNNVFSYPQVSTYPFTTSSTTLLFSPLDMMTHQSTPSPTITNPSEDFEILDCNNSYQDFSSDSSEYTPYNYQEGCKLVSLPADYLSAANSYFMQPVYLEQDMWCVSATNQSCDMMDASNLVTSDNMAASPGGQIDSPGSLYYIGHNKDGVSLKGDSTDLYVPPEPVKRPSTSTKKGQTNKSLVRECQCPMCPRAFARKHDLQRHIRVHTGAKPYSCPCCHRNFARTDALRRHFRMEESCRASPQVLEMKTRRRKGRIVMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAX3</accession>
    <name>A0A8H7UAX3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">chitin deacetylase</fullName>
            <ecNumber evidence="20">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">INT43_004602</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="20"/>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAX3"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10952">
        <property type="entry name" value="CE4_MrCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000004">
        <property type="entry name" value="Related to Chitin deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF98">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="18" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 23" id="KW-0732">Signal</keyword>
    <keyword evidence="22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034332334" description="chitin deacetylase" evidence="23">
        <location>
            <begin position="19"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="24">
        <location>
            <begin position="142"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAG2173228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="424" mass="45131" checksum="0C5EAA9AD3674168" modified="2022-01-19" version="1">MIWESVFATAALFAGVSAANMPSGLPVITIPDIPQTTSYDPTVECTSYTVPGLTIDPTQWPTIWDTATTNGMNTSAEFTALYNSINWANAPNYPVRTQANGALDFTGYDQNADPDCWWSASLCTTPKLAGVNADIYKCNEPETWGLTYDDGPNCSHNAFYDFLQQQQLTASMFYIGSNVLDWPAGAMRGLKDGHHINVHTWSHQLMTTLTNQEVLAELYYTQKAIKTVVGVTPLYWRPPFGDVDDRVRWIATQLNLTAIIWNLDTNDWAAGDSEPIATVEAAYQAYIEMGTNGTFANDGNIVLTHEIDNTTMSLAMTYVPQIVKAYKNVLDIATCANLSKPYADSDITYAAFGGSNASTSAAASGSSAASGSVGGSSSTTGSSSGSAASAGTNNVANASGAAAFKPATAVFGLVLMAVLGFFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UC43</accession>
    <name>A0A8H7UC43_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Osmotin thaumatin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UC43"/>
    <dbReference type="OrthoDB" id="430315at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31013">
        <property type="entry name" value="THAUMATIN FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31013:SF2">
        <property type="entry name" value="THAUMATIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002703">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00347">
        <property type="entry name" value="THAUMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034456113" description="Osmotin thaumatin-like protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="37"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR002703-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2180141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="24581" checksum="7D120BA8D97E1880" modified="2022-01-19" version="1">MLNIIKLSALAALTGMTLAAPLQSRDSGKTITVKNNCKNTMTVGWLTNGQSNDHTTLFDLSAGATQSISPPGSNWGGRVWGRDQCSHSDMTHCGTSGAVSPASLAEFLFNGSGGQDYYDVSLVDGYNIPISISPDGKSATSKYQCGSPQAANLPSCPSANQVVVNGQNVGCKSSCSLTGSAQDCCTGAYNTPDKCSINSFAQQVKNANPDAYSYAYDDQTSTYSCNPTGYTVTLCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UC98</accession>
    <name>A0A8H7UC98_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_004302</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UC98"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000328">
        <property type="entry name" value="Septin spn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="14"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="311"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2174279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="366" mass="41805" checksum="FBA3CA9F3994C4C2" modified="2022-01-19" version="1">MAHRLGGRRKNVKKGFQFTFMVVGASGTGRTTFVNTLCDSGVLPKKVSDNAEEAHNEAGIKIKPVSVELDEDGVRISLTIVDTPGFGDNIDNEKCFQEIVGYLESQYDDILAEENRIKRNPRFRDNRVHALLYFIAPTGHALREIDIELMRRLSPRVNVIPVVGRADSLTPQELRDFKRRIMEDIEHYNIPIYNFPYDAEEDDEDTVEENSELRTLLPFAIIGSDEEIVVNGRTVRGRQYPWGAVEVDNPKHSDFARLRSALLSSHLQDLKEITHDFLYENYRTEKLSRTINGGDQDGAALDADEMASQSVRLKEEQLRREEEKLRDIELKVQREIQEKRQELLAKEEALRSLEARLAAAQLQDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCC5</accession>
    <name>A0A8H7UCC5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">intramembrane prenyl-peptidase Rce1</fullName>
            <ecNumber evidence="10">3.4.26.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_005581</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="10"/>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCC5"/>
    <dbReference type="OrthoDB" id="271604at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="12">
        <location>
            <begin position="199"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2176347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="334" mass="37205" checksum="6CEAE54982621FC5" modified="2022-01-19" version="1" fragment="single">QKMDVMSEEKPSSDNQQYCLFNPAILKYTSVFVGDRYTALCNKFMPAVIPSIGQIPKPVAALVCVGFTVIYLAGFYVFGNIRTGKTGLSRNDPRVILARFRAVTVSSITAAAVVWLLLKTYGAWDENTTSSDQIHSLLSILGVLTPSSITAIANLLILPLLLTASLFLGPLSILYMEQCLIFQYHFNFKRDVLQTLSSLEGLRNYIVGPLTEEFVFRACVIAVLKFSGYSTNYLIFASSLYFGLAHLHHAWETYHSYGANAKALKTALLQSGFQFVYTTVFGWYVSWIFIRTDSVWAPTICHTFCNIMGFPDVGAISNFRPRTQKGKTVISIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCD2</accession>
    <name>A0A8H7UCD2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCD2"/>
    <dbReference type="OrthoDB" id="101791at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="4"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="DUSP" evidence="2">
        <location>
            <begin position="197"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="37714" checksum="CAC1D917CDC972D2" modified="2022-01-19" version="1">MYNKSQLESLSQEVLLMIARQLDYLSLIRLGATSRRFHTVLNDDMLFKELLVLDYGVSYKSPDETWKEQYQQKWSDTSGRRICPHLSSVTDDILLEKADTFKSAQESSASCSKCSMSQFPNLMLVMEKMEKDVSQGSNLGIYLDMSTLRLRCFLCRMRRTPLGGFGSDRSEQYKCELILEVLIAGTDAGKEKVDLILKRKKEREMYVGQQDELASTALKQVKCNLVDAQWMGRFHLFIYGGYPSPGRITNRTLTRRNGTVIPDLKLYGEDVALVTETFWNHLAQEYGVEGRAVTEDDLQGKEYAALRQKINLMKRKMCNQAKRETADKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCE4</accession>
    <name>A0A8H7UCE4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_004437</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCE4"/>
    <dbReference type="OrthoDB" id="1724687at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047861">
        <property type="entry name" value="Ribosomal_eS7_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00948">
        <property type="entry name" value="RIBOSOMAL_S7E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2174414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="194" mass="21824" checksum="FADFAE16CD319F23" modified="2022-01-19" version="1">MASHKIAKPAGAAPADEVELSVAQALVDLENNVAELKKELRPLQISSAKEVEIGGGKKAIVVFVPVPQLKAFHKVQQRLTRELEKKFSDRHILFVAQRRIMPKPTRHSRQKQSRPRSRTLTAVHEKILDDLVYPTEIVGKRTRVKVDGSKTLKVFLDTKDATSLEYKLDTFSSVYRKLTGKDVVFEFPANVEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCM7</accession>
    <name>A0A8H7UCM7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCM7"/>
    <dbReference type="OrthoDB" id="2363028at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2178040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="571" mass="63474" checksum="B6C083B167CF4D2F" modified="2022-01-19" version="1">MRPFTLFASFNQLRHFLRTKVTELVQPPPKITTLPPSPFVVVDNVRASIIRLQQQQKHQQALFHLTAEQEKVQLLSFLQRQFPVVKVFAARPNVRPVGMFPVPRGRQFQFRTIVSSGTSTISQTGNNAGAGFSRTAVVGYSRTPFARNFSTGKPQSIFQATNTAGGSGQTSVLSQVPSRTFSVTSKMNQSNNSSPEHSPVPSSNLSDNEDSAKDNSSGRYTNILAKNDSRGIFEVVDQYDETDGDGPGLVRRVSIASRRSSVASSPRQGRHNKSDKAQYEFMRSDDLSEIHGGSQLSKWPMRTPRKPPERHRIEKRYAPRICMSFMLDGAALWDSDILSSPSSSQSSGYLDISFIRSVESAADLYQNHLSNVIVILRRLSCHGRFKVTVAGSEVRIMFPEELSVSFMQPEDDGPLHRSQGTRLWLRSIGIDPDSPHFILETYYGGVTDSSTPMKIPNSVAESSMEEPLPEDMVVLSTDFSNMLPKPPSRRSSAPTERQRTAAASFSSDTMYSSHRYQKSRLSGRASSLPEHSHNGLGPEYFKGIQEFLDHVDDLIETSDAFGKKDISSKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCV0</accession>
    <name>A0A8H7UCV0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-type Na(+) transporter</fullName>
            <ecNumber evidence="19">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">INT43_007541</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="19"/>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCV0"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000016">
        <property type="entry name" value="Calcium-transporting P-type ATPase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000047">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="883"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="926"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="967"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1000"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="24">
        <location>
            <begin position="76"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAG2176887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1033" mass="112977" checksum="04B6F075CE09463E" modified="2022-01-19" version="1">MSTDGQNNPSVPNNITISENEKPSKSSTNLLGRVNTSNSAATSNTDTMSVRSRVMKSMNFKKIKNKDNANVSYGPDYHAMDVNAVTEILKTDTEQGLTEDEVTERQLKYGHNELAGEGGVSAWKVLLRQLVNIMILILVIAMVVSFVFHDWIEGGVTAAIIILNAGIGFFQEYKAEKTMDSLRRLASPTSKVIRSGHLVTIATRDLVPGDIISFKHGDVVGADCRIIECFNFEVDEALLTGESLPVNKEPATIENAEIPLGDRVNMGFSSTVLVKGRGQAIVTATGMNTEIGRIAKRLMDASENSKTPLQKGLDRMALVMLGVAIISIIITFGAAKFHIDDEVILYAISLAIAVIPEGLVAVVTLTQSFGVRFMAEKNVLVRRLAALENLGSVTNVCSDKTGTLTQSKMVMTRFWLPSDGSFNVSGRGFIPEGEITRESDMELVSQDNMLSPMRQLLEISSLCNTATIHKDKETQEWITQGDPTESALQVFAHKMDMGNKKLTNTDNGNAWKLLAEYPFDSGVKRMSVIYRTPNGENVAFLKGATERVLPCCSSVQLSDNDGGLKSISSEELEQMISPQVENLARDGLRVLALARKPMKTESDIGPDDFTRDEIDVDFTFIGLCGIYDPPREESKQSVESCHEAGITVHMLTGDHHATATAIAREVGILPSNYGREEEEKSDHHVANTDKLVMTATEFDKLSDSAVDALPSLPLVIARCSPDTKVKVIEALHRRKRIAGMTGDGVNDSPSLKEADIGIAMGQAGSDVAKQASDIILTDDNFSSIVHAIKEGRRVFSNISRFVVHMISGNVAEVTPLLIGLAFIDASGASVFPMSPIQILFNNILTSSPPAMSLGLEPIGADAMRVPPRRRDEGLFCRSNVVDIVFYGFMMGIICLCNFVVVIFGYGDGNLGTECNRGLNEGCELVFKARGALFATMTLLILLHGFTCRDLLHSTWNWKTLTGPQNKYLFYSFGVGFVLLIITLYVPVLNTSVFKHSPIDWEWGMVIASCFVYIGIAELWKAGKRSLRRRQGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UD70</accession>
    <name>A0A8H7UD70_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial group I intron splicing factor CCM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UD70"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936:SF1">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN GUN1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936">
        <property type="entry name" value="PPR_LONG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="293"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="399"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="434"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="505"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="541"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="576"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="663" mass="76169" checksum="A2608699F083959E" modified="2022-01-19" version="1">MQAASTATRANLRNALQHCWINARLNTTSTRKLMPLVELASSRKLQWHKVFNTWSVNASQAYYSTSSQSAIYDEELKPINDENLVEHFKAMVQKGHANTSMIYDKLRKLNKLNQLDTQDFASLRAHLWSTKAWGSEELVEQVLFDQKFCGHAWSVLEYNDYYMSMLFQAKYSDIVSNFEEEFKSTEMKPTVATINSVIAAYIQMNQLDNARDVMAKCAQWELTPTIQDFERLANRCLPRNGKVIKEARMLIMNNALKDPKAMNRHLQHLFRANKLPEVHKLYAVMKKDTNAVDISTYSTLIKGYLDKRKYEEVNKIYDEVCDTGRPMNAFVASLMLDAYAAQRDKVQIANVIERMRKDNVIMDIPLYNQVIKAFFATKQVGVAVAIFQQLQKDQHAQLNTVVLNTMINGLLQNREIDAAKKIYSDMLKSKIQPDMVTYNTLLKGLTKTRDFEGALGVLNNLYERSLEPDIVTYTTLIDAMFENLNPTSTEEIMRIFKNPKAVKPNVFTYNVLINGWIRHDNLPEAERTFKMLLDSQDIQPTVHTYTNIIQGYVQNHNVSKAMSAFQTMLTNGVQPGRATYHFIISGLINDGRLDDAVECLKRMTLSGKMPTKDTWYMVLNACYDTKSPQLGAAVLKELDESKFDVRSEALRRVYRLVRDQSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDI7</accession>
    <name>A0A8H7UDI7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_001834</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDI7"/>
    <dbReference type="OrthoDB" id="3232309at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466:SF1">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="118"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2178985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="330" mass="38740" checksum="A20995670A334E44" modified="2022-01-19" version="1" fragment="single">FLIQFPIIDSILKGNTCQPISMREFKLYLQNKEHSAENLDFYYWYLDYSERFYNLPEHERACSQPPADKPSVASYALPLEALIKQPSIRSSRHSDETSTNVNTEKQSTEINEKDPRNQPFREEVNAALRTFFNYDSEKELNIDGYLRRYIVYYANRTTHPDVFAACHDKVYQIMEQSSLRSFLHHALQNIRYDGIVFRYSMGLFFLLAVILILTLTFVFHTVRWYRLLVFPCVFGCIFYILSGRAGMCFRRALRNKRQVPLYELDQEHMDDMKNQKRKTLDIESISDIKSIIDPHVLNYNKLLFMHTFSVAALTALSVTVMAVSLTNEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDR3</accession>
    <name>A0A8H7UDR3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">YTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_001366</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDR3"/>
    <dbReference type="OrthoDB" id="306690at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057720">
        <property type="entry name" value="RRM_YTH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25701">
        <property type="entry name" value="RRM_YTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="52"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="YTH" evidence="4">
        <location>
            <begin position="262"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2175719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="59056" checksum="294C9A15E5ACFD69" modified="2022-01-19" version="1">MSDTIQQLPPASSPPPPTPPPLADKDSPEHSKSNQPQTAQSGIQQKPKNLENAMWVGNLPTDTTPEELRDFFYDDDFLTVFHISKTHCAFVNYKSYDAVLRAVKKHHEADLLTDFHPTEFHGIRLVCRPRKHNHSNPPRGMVVSPRHMHKGIPPTSDAMPALGPPMMMAGYMPQPVPNSMRFNQYPGDPRYHAMPPPPPLPTTSIPPPQTNSSPSMGDFRPRRASQLSRSSRDSSPRSQQRHSPQERHTSLDSSTNGNHPNVRYFILKSLTTDDLDISVERGVWATQPHNEANLNRAFKTSSAVYLIFSANKSGEFYGYARMMQPITPNEPSSPSIQVQWTPVPMAEDEEEDTETKANDNPADNLENHDNKQSEENQQETGSGGGGGGNEKRWGNAFKVQWIKIQRFPFSQTRHLRNSWNNNREVKVSRDGTELETSVGEMLIQGFHWAEQQQLYQQQQQQQQQVAPQPYQQPMMFNGDMQPPSQQMMMGYVQTPHGVQLVPIPFVNVGIPPSPYPYMMGDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UE15</accession>
    <name>A0A8H7UE15_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_003385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UE15"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2178132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="214" mass="24427" checksum="80304CD370214772" modified="2022-01-19" version="1">MDRSQKRLFDRVSSFFQRRWWKKPHTACEKSLEPVTAFVPELRPQAIIKPGIIKKQDSAVSVSSTNKTEHAFDGISEHSQQSFVPTEPIVNLSLMDASVATSPSRRRSTLRRQSQLSKPAFRQIRVPLQPESDSNSDVVSELLHGVETMSLKNKSTIRKPRTLLRNRRASNKRQSTGLRQASELAARLNECSFRSVSPFEIRELRQCLQNADQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEF3</accession>
    <name>A0A8H7UEF3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_005628</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEF3"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12254">
        <property type="entry name" value="RRM_hnRNPH_ESRPs_RBM12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050666">
        <property type="entry name" value="ESRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="146"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="403"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2176394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="534" mass="60190" checksum="5F7D196D04E387B1" modified="2022-01-19" version="1">MVESSARDTDLSDISNDPIVTSDSSQSSILDDTDNSIDSIVRCISRFRHEDNPDQDRVNDTLGEMLDNSTLPLQLFNSQNSSSQEVFDQKVNAFISIADQEKQQISSPTVSSVSTALRSLAETTSYRRLSPQDQNSGQSFSSIKWSVVKISNIPWDISASQIAVFFHNLKLPQQSVHSHSIHIMVDRSSGKTLSNAFVELKDQEEVRSAVASCNRKPLKGRLVHVSMSSQDELLKAIFPSWSGDFHNGLAIRTNDDTEPSKLGHTFITRQEINSLLTICRNYKVDLVTKLQIHFSRKCPERPFENVMSIVCKYPWYQPDLVTALQRDHIYECLKLAIECLCSHIVKEYITIDPTLLSRMVRTGIMCPAFTERQQTVILNASGQECPEDAKPFIFYNRPRTSDALTDETVSGTSDIEEGDTREPSCQSSSEIKEKLPQKSEMKIWDDCTSKNLIDLSDDDLISDATTNHQQWQSTLVAEPKRNSTSKHADHQCSLSIDSNNHSFGTSYNSDSSNQLLIEERINLLCQQLKSRHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEV3</accession>
    <name>A0A8H7UEV3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEV3"/>
    <dbReference type="OrthoDB" id="410920at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031434">
        <property type="term" value="F:mitogen-activated protein kinase kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024104">
        <property type="entry name" value="Tribbles/Ser_Thr_kinase_40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22961">
        <property type="entry name" value="SER/THR PROTEIN KINASE-TRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22961:SF13">
        <property type="entry name" value="TRIBBLES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2177323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="530" mass="59990" checksum="899C7D7FF748CE76" modified="2022-01-19" version="1" fragment="single">MPNIFQRPARALSSFAKFLTPSQQDESTAKKTKRKSRGRALFQRIAEASSVKDHSRIISADRDWRNLSPMEPPLPNVSPSRRVGFSHAVKVVQNLPADMTDLFKRPPPTTRQRDSTGSLEDFLYTIPEEDEVVSDDIEESDVPDNSDDASPPKKSLEPQFKPILIGNEKECKRKFAKMLHAAYKFQQQQDQLDSLGKSEAAPTSMESAPYARKQQNLQKPPREMEVLFNQDDNVEWVKFKFDLDEEGEYRRFQGNQVDVWVLGISLYKMLVGRYPFAAPNDKQLFKKMLTADFSIPEEFSDNVKDLLRRLLAPDSTRASLDLIIFHPWLKPYQIIPKENTPVDAAISSSAASPSRQLIAKRTTNANAVKDSRDSLMEAIAEKRMNSNVRVLSPLSGRTMEPQASPLQKEVTLSDSPNASVRSRSSVLPEHDSALDRSSSESNEHSQIPENANEGIAHTQQKKRNRRSLVLLAKALSDAFSFVATGPYAPPRNPYEDLVHLGRNEEEQAMHERQQQVRRSWRSYESSAVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFK2</accession>
    <name>A0A8H7UFK2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Up-regulated during septation protein 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFK2"/>
    <dbReference type="OrthoDB" id="5569911at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029191">
        <property type="entry name" value="Uds1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15456">
        <property type="entry name" value="Uds1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Up-regulated during septation protein 1" evidence="3">
        <location>
            <begin position="194"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="875"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="338"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="474"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="618"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2178043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1077" mass="123326" checksum="164C248DFA14E743" modified="2022-01-19" version="1">MAKPAPNKLLNNPFFANRHQPVIKANQPDAAISPGKLKNKWQQPVATPKKEDNTDSKLSLTEKKQTIKQTDTPPVPIESAESSPPVNLSEQLTPNVPELKSQTPAPVRETRSVPKSPSPAASQTEPKEQDQISISIISKLDTAQKDESATRKSFISTASLESPLPWQNFENVEGSRLSLPSISNVAEDMDGMLMQLLVSQAVIDAKDFEVLTLEEVETLKQQHINLMNRLEDQTARLSLESKMREASQSLVRLHSTNRKMALQSQEQLIASTQKVDEVAKEVWRLTRLGSETQQRLLEHTAGTLSVGVKVLEDELSIQSRKATSRPTAQTSANADTRIKQLTVDLVQRDNEIKRQQEEIEQLRAQKLCDMEFETASDVQAKEREIRELRTEYEHLHNGLDFLVRRYQIAEDSIRIQPSDAGTISSASEDSGSWDGVHGGNDFSFKSVHTSTTSIGDVRNDEYSLHHGSAHTATLNAVEKLLKEAELKVRRLESEAEDSRMALAQSQQKIVDLQQNDQSDDYLQSLKTLTAQRAQLQQELESLRNEDSRIQTEAEKSHKNNASLLEKEVAQTRQQLEKLEVDLYGLTELFPVQKSNNLHGNKTPLELAAVKIRDIVQENMRIEETMSHMESSIKEHEQQRDNLMTELQTTRKQLQAVSTRASSPAVDTRAIEARERALQRELQQFKSEVFDLRSQREEWERNVNNQSTVELTQEHLDEQIACINARHEAQTKAIQDELKLLRDQLESTVQEKQRLQCEAESLENQFKANKQAMDKMKNEINMKDNSINSIKLELDSVKENLIAKTKEEETLFASEQQIHKNHELQTQMLKQELADLDRKMRQNANQAEELISSKNQRLMAANEHIERLENDISQLQKRASSTATAQPLQNGELQSLQSQMDEVCRSRDMMEMELGITQKQLRETQEALLTAQSQFTVRESALLLQCSSIETDFEAIFKEYERLTRNITDFASERHAYDERIRELLQYKNEIQTELADEKVRCLQVGKEPNSTQTLRREFRKLMSEVKAEHARELERAEEERKKLDAVLRNLRREEEKKRWEKQSRGVQTNFVVDLVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFK4</accession>
    <name>A0A8H7UFK4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_008772</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFK4"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46225">
        <property type="entry name" value="C3H4 TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46225:SF19">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="283"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="441"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2181190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="498" mass="55113" checksum="A4DA8645FF5FFC7C" modified="2022-01-19" version="1">MAGHEASSVLEIEPESQVATAGSSDHSISTSLPDVSSQAAAQNLGAATSLSPTDTRAQSSILLESLSPSNAVAITTRTVNTTSRTVRWNWVNYLRDRWRTITSSNKMLLIFTLFLSTVQIVTSIIAIAISDDGVCERPLKIFLIVYTVRVILSFPFSVYQYLHPRRRRRTTRRRRGQTLRPAQIPQSPTATPGGNQDRRPPLSEAASAQNTSPTSPSTSITAISPADTTPTADNNAHSRRDFIIGARVDRAKSLLDLFATFWFVVGNYFLFGSTSCASSANILFYVTLAWVVLGYIMITIPIIFCAAAIFCLPCVLGESVISKAISDVKNVLFKPLLLVGLRIMQVGEPSEIGGASPEEIKKIPVLRFTADPNETSSIAESHISIRSAVPQRSEQHPRVGFFRRVLLKKTRKAKSQPDSQPPKSKEEYQSISFDNSEDAVCAICLSNYEQDELVCRLWCQHHFHKDCLHEWLALNSMCPMCKQDSRGKEYELVEVEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFP1</accession>
    <name>A0A8H7UFP1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_003719</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFP1"/>
    <dbReference type="OrthoDB" id="20689at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09392">
        <property type="entry name" value="LIM2_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017351">
        <property type="entry name" value="PINCH-1-4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24210">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24210:SF14">
        <property type="entry name" value="LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="79"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2179932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="300" mass="34329" checksum="87482EEB9CF43462" modified="2022-01-19" version="1">MATLTASPPVDPVPSNICAVCAKPLSKKSVRALGSAYHYDCFKCLICKEPLTSLRFFPLKEDGKVFPVCERDYFKRLDLTCRTCGEALRDTYIVAADSKYHLNHFTCSQCDTHFGPDDLYYEHDGAVLCHYHYSTQYAIRCTGCAVIIYKQYVEGNNNERWHAECYMINKFWNVRLSDYYGHERYGMIDNVLQLRSQKFKVLIFVFGESAALGEDAETAKKMEKDTEEKVYQVWTVLSAFEESSAATISEMLLHVSIGKHIEGVNMAKRFIDHVHILFKAINLLNEMFSKGPISSEKLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFQ3</accession>
    <name>A0A8H7UFQ3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFQ3"/>
    <dbReference type="OrthoDB" id="5555533at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037652">
        <property type="entry name" value="Mim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28230">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28230:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19117">
        <property type="entry name" value="Mim2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2181340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="101" mass="12020" checksum="F55379979FA2155D" modified="2022-01-19" version="1">MSEPTDLYSGLQEALRNQELYRQDDLDDIDEGNDADYLDEESESSYDADLEWEESKEQIHLLLSMVIFPFVGKWLGRKFSFWVWSKYLHNYYVEGVRRIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGP4</accession>
    <name>A0A8H7UGP4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_002078</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGP4"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034380422" description="Peptidase A1 domain-containing protein" evidence="11">
        <location>
            <begin position="20"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="12">
        <location>
            <begin position="65"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="96"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="357"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2179228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="491" mass="50622" checksum="7EEC5B6FAE7570F7" modified="2022-01-19" version="1">MHISSSLALLCSVAAVALAAPVEEEVNAKPLLRVPFKKVAKPNGHRLTKRDPFQSSLYNDNGSQYLINVDIGTPAQNFSVALDTGSADLWVPGTSCPTNTCPYAKYDSSKSSTFKNTNEQFGIIYGSGSANGTYVTDTVTVGGATVQNQQFGLVTTTADILTNQGSLGGGVGSSPSVTQNSGPVSDGIFGLGYPQLTASTSDGGQVYNPFVFNLVQNKVIADPVFSIYLNTASATGNSGEIIFGGVDQSKYSGDLAYMPVAGLESGSDSNPLDSIFGGGSGNSQTYAYWMVYGQGFNVVNGLSSPNLTMSTTVPVILDTGTTLTYLPQRVAQEIVLSVADQNDIKIDQSAGVYVVGCDVANSNAQVQIQFSSSSKVSDTPITFSVPVSQLVIPLDGNTPSSATQCIFGIAPSSGGSSSSSNLYLIGDSMLRSAYMVFDMGQNRVGLAAANGVGGTVNGIQASASAATSIVTSQPITMVLATSIVAAALWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHP8</accession>
    <name>A0A8H7UHP8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2,3-diketo-5-methylthio-1-phosphopentane phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHP8"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF2">
        <property type="entry name" value="PHOSPHORIC MONOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27831" checksum="3B824236D2AE6991" modified="2022-01-19" version="1">MSKSLNIQVYSDFDGTISLQDTGCLLIDDRRCLGYERRRELDHLMLDKKVSFRDGLEEMWAAVTLTWEEAWKDHLSLVKVDPGFSDFYDYCKSVDVPVKIVSSGIYCVIEQIMENFIGDRAKEIEIISNGGGVDGRKWSIEWRDDTPFGHDKSLTLKKAREQAPDDAIFVFCGDGVSDISAAQHADILFARHGRDLEVYCQRENVPFRGFDTFEEVQDVVSKLVSGHIRLERDEKTGFCSLIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIT5</accession>
    <name>A0A8H7UIT5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_006312</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIT5"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072670">
        <property type="term" value="P:mitochondrial tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24134">
        <property type="entry name" value="ASKHA_NBD_OSGEPL1_QRI7_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000012">
        <property type="entry name" value="tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="8">
        <location>
            <begin position="54"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2183307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="396" mass="42661" checksum="D4E9A00535C4CD9E" modified="2022-01-19" version="1">MLSRLRPRLLKPLNLAKHQHAWRSYSAKKPLVVLGIETSCDDTSAAVVTSDRRILSEVVRTQHQLHESMGGIVPTIASTGHMKNLPSVICEALETANTNINDIDCVAVTRGPGLPPCLSVGMNAAKTLAAVARKPIIGVHHMEAHALTARLTTENADGSCLPAPAFPFMTLLISGGHTLLLQANAVGDYDQLGTTMDDAVGEAIDKASRALGLKWAQGRRGGPGVALEQAAAKGDPSRFDKFLPLPLSEREWTKKIGFSFSGLKTAMIRMVEQHKIAGNDQDVADAAATFQNKCIQHLEQKLRLALDKSVKQNNTPLTALVVSGGVASNSLVRSRLEALASSYGLPLICPPPKLCTDNGVMIAWAGIERYQAGLMDDYEMTTIPKWPIEQLKSEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UIU3</accession>
    <name>A0A8H7UIU3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL15/eL18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_000628</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UIU3"/>
    <dbReference type="OrthoDB" id="361383at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_uL15_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="117"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="30"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2184715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="256" mass="28394" checksum="A981C2A4F4129A7C" modified="2022-01-19" version="1">MLAQFAKLSLQRSVSRPNSAAIQSVRLLSTDGKVSPPSDPVHLGNLADNPGAVTERLRLGRGPGYGKGKTAGRGHKGQNARSGNGPPRPWFEGGQTPLVKRMPKRGFFNQYAKKYQPLNLERLQHWVKDGRLNPEKVTLTELVQSRCVHKLEDGVKLLSDGAEDFHVPVNIVVSRASRKAIEAIEKAGGSVTCTYYNNLALKVMKDPVEWMSKRRVPKFAQPVKTKDIDWYSDPKNRGYLADPEAIMTEKAALKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJ48</accession>
    <name>A0A8H7UJ48_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetrapyrrole methylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_000958</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJ48"/>
    <dbReference type="OrthoDB" id="508204at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000006">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050161">
        <property type="entry name" value="Siro_Cobalamin_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004790">
        <property type="entry name" value="PRK06136.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790">
        <property type="entry name" value="SIROHEME SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790:SF6">
        <property type="entry name" value="UROPORPHYRINOGEN-III C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="5">
        <location>
            <begin position="9"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2185045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="242" mass="26219" checksum="5D61FF094B56B1C3" modified="2022-01-19" version="1">MSTSTEGGKIFLVGGGPGDPELITLKAQRLLQTADLVVSDRLIPQQVLDLVSHELRIARKTAGKSDQAQDELLDWCMEGLKKGQTVVRLKIGDPLLFGRGGEEVLWFRERGYEPILVPGISSAFSAPMAATIPVTHRGVADQVIITTGRGTKGSMPNLPDYHPTRTLVVLMAVGRAADLEKILLEEKKYPISTPVSWVENANCPEERTVYGTLENLAKMVEEQNIVAPAVLIVGLSVGILNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJB7</accession>
    <name>A0A8H7UJB7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exocyst complex component EXO84</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_006838</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO84 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJB7"/>
    <dbReference type="OrthoDB" id="642193at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25345">
        <property type="entry name" value="PH_EXO84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst component Exo84 C-terminal" evidence="8">
        <location>
            <begin position="295"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="245"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2181913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="689" mass="79172" checksum="C27C5ADAEB4B3E73" modified="2022-01-19" version="1">MRESVADANEEQLRAFYRSLNDAKGLVGSDLQRNVYRNYTEFVVISKEISNLDGDMLLLRDFIKELRTISASFKDEVDPMAGMVNDSTPISESISQRRKPTEMATSDMQTIYRVQLSALWQSIEGAQRLVPFIPDRHILREFPNVAELHPKTMQARQAAQFILLNDCILLATRKKRTMSYKVKLVADRCWPLGEIKVQDVKNNSEVLNTIKVVHFQEVFFFRCERPEDKGSILIAVQRATDELLDHTKQNEAENSRGVSEPLLEMQSQVESRTKKSRPDRDPAKQMPQLSSADMKWLAELPDELEVFIALREFEEAVAYIEKARAIIPSFSADAGQLESIKEEIDVFVEKLSKAIGRDLSNSLLTKVQFQRNINWLLRLGLGESGREMFLATRAAVIKKRIRQLTFEGDVTTYINELSLIVFTLIRNTCEWYRDSFKDNRMASGTLAARFVTWVKEQITAYAQIFNKQVFGQNSFNLRIIADCLRSTTDQCTLLRKVGLDLKFLLDDLFAEEIKALIIAYEERCIGKLDKIIKEDRFLVVSSQSLGTDVKVTASVVSFYNILIKFVNEACLLVKLPLYTTLITSISNIAEQYLRRMVKESQSREMAKDQRYAAMMNVAFVLDNVVPRISSQLNRHFDRPIPELDTLRATMRGKQITIYLDTFNVEYSPVAWVCRTNICLKNLKNFKLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJK6</accession>
    <name>A0A8H7UJK6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_008927</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJK6"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001301">
        <property type="entry name" value="Structural maintenance of chromosomes 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="12">
        <location>
            <begin position="61"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="686"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="217"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="340"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="412"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="795"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2181344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1124" mass="128562" checksum="70477351E77B7A4E" modified="2022-01-19" version="1">MAAATRRNKRPAQDLPSDSSSDEDQSTAKLLKTNSGAAIATTSQSDVVLQADINGFVNGSIVRIALKNFVTYDYCEFFPGPQLNMIIGPNGTGKSTIVCAIALGLGGATSVLGRARNISEFVKTGQTSATIEIELRRISGHNLVIQRSIQKANNASQWKLNGETRSQKEVMNAISSMNIQVDNLCQFLPQDKVAEFAQLSPPQLLERTQVAVGEMQMSQWHKKLIEFRREEKKLREERQSDEDHLKTLRDRNAYLERDVVKMKQRDIIIKKIAMLKAKIPLAKYADAKKAYDSAKEARKTTEEKLKRCKAENAPMDAVKRSQEERLKVLTHKFNQKNQSVDRNESQLKEFATQIDNLATEITDNKNKIDTIKQRAAPRAQLISELKATIQRLESSLTEGPPDADTSTVQVEIDELSRKSRDINDDLSELTDTQRDLERQVRRVDQAVELKNRQSALKRLQDLQSVRKQRLEKLREKDPDTFKAVQWLEKNRDKFTGPVHEPVLLAMNLKDTNYASAIETILGGAQGPHLKGFTCELQQDYRLFTSEVIDKMKLKVNVGWPGRINMDSFSHPLPIERVRQAFKLEHYASDLIDLPPFVLGYLCHQTKLHAIPISLHSANEAQISESGKFRRYVVQDTLYEVRNYSYGSGGQQTSSRRMRNAEYLSNSVDIEVKNRTENELRHLMEQQKDANEKKQEARNKEKQLRQQQHELRDQRETALTKKKEIQQLLQKYSARKLKLEGKRKELDEAIAKPAQDQTEIAQIEQKVKRAVGKRIELAKKYTSLLETDYVPGAMQRNDLELELAQVKAEIDYFKKVYDERTLALREAQQEYASAELTYKDAKAKAKSALELAKKAGEELREQVSTEQSAEYAELFERFQNDEVEISLAAVEDEINSEQAKADALRAANPRAMQHYEQRLKEITTLEEHLGTREERLRSMENNVQQIRNLWEPRLRTLVSSISSKFSAAFQEIGCTGEVNISEHEDFEEWGIDILVKFRDTEQLQLLTGQRQSGGERAVSTTLYLMSLQELARSPFRVVDEINQGMDPRNERMIHEQIVRGACKPGTSQYFLITPKLLPDLYYSDRMRVLCIYNGEWQPSKLKPTSHYLEAYRKSKVPSQTVASAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKA6</accession>
    <name>A0A8H7UKA6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein Zds1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKA6"/>
    <dbReference type="OrthoDB" id="5589766at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040206">
        <property type="entry name" value="Zds1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013941">
        <property type="entry name" value="ZDS1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089:SF1">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08632">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01327">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein Zds1 C-terminal" evidence="2">
        <location>
            <begin position="556"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="741"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2184882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="842" mass="93551" checksum="C9861441111C4CBD" modified="2022-01-19" version="1">MNMRTGANELSHQAVTSASADRTDIQLDEQREDSVETASKKSDSGIYMDSNGETQAWSGHHIDRDDQRQSNANGQSEPSRQDADTTYTEDTASVLSNGTTISSLIDEEDEGKQVYNIETTNPSRLFWVPAEQHPEIAPAEFANWLQTHGVIRAKGQLRVRRKRSILSISYLPGEEDQDVSEIHPRRRSYDAAMKRRPSKPPQSISFSGAIAEEEEDIHTTTLNNDILRRSVSLNVQAPAGRQQFDGSKTQVFDRHSTARDESPVLVPRAEGSLLRRSNRTKLRKSSLQTSNRDSSVPVNRRPSQRSQSAYGKPADSSDRFGIVPPGGITLQDRPVSISELVDFGGADYEPAESQQGIITRVHDAENEIFSRIAAEESQQETPVDTELSSAQRHQEGGAVLIDAPAKVNIKELSPIVHNAVDEKEVVQVSSPDIKVNHKEVELVPQRPKHNRSKSERSVLSVGKPEKRSSWSFKFLSDDKSKKKPAEQRSHRAPSVNSTVTESTALVKSKNPSNDLLANSAKMFGLSSLFQRTSIRSPKAVPNGNFSMNKNTSKDNVAKAPTNDWSRFPIHIERAVYRLSHFKLSNPRRPLHHQVLISNMMFWYLSIINGQQVRPHQQQSQPKPANEDASTVSPSPQSFIVRSQNTYQEEQEAAPAKLGKVSKFINASKRRRQDIMVKKQMQQQFHHQPRWLPTIAESALAPNDVSEPEAKTPPSRPNDGYHDADRPVSPTQNGKEYPQPPSTIASTTTAPTDKSLNTGKYSPIPNEQYQPNVGNSPTTNKPSLTKATTPHPLPPIPGPPLLGELSRFHSFSDDILSSLGFEESSIQSGEDDDVPLGLYRKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKP5</accession>
    <name>A0A8H7UKP5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-mRNA processing factor 4 (PRP4)-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_007339</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKP5"/>
    <dbReference type="OrthoDB" id="540662at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001211">
        <property type="entry name" value="CBN-PRP-4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000443">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="5">
        <location>
            <begin position="80"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="201"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="243"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="293"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="335"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="377"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="451"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="477"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2182409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="515" mass="57432" checksum="6FEC0714784A21FE" modified="2022-01-19" version="1">MDGSQSDRIHFGSIEADERRRNQSQMAVDQEDDAGVSLEDLAEDTHFELSGSSEVARDEQKAVVEEFERRARARQLAVPTDDGRVRARLRELGEPQCLFAEGPGDRRDRLRYLLSQRAEGEVEDEEMESAEEEEEKEEEFFTPGSQELLEARKWVAQYSIPRAKARVLKHKAEQDIPIPQLRKARKELHNSLKNYTNWSSQLADDRPLAQTAFSPDSSMVITGAWSGLCKLWSVPNSDCIRTLRGHTDRVGGVCFHPQSTISQDKSSLNIASGGADANIHLWNLESETPIASMSGHAGRIARIDFHPSGRFLGSASFDGTWRLWDTNTTQELLLQEGHSREVYAIAFQGDGSLIASGGLDAIGRVWDMRTGRSSMTLQGHVKDILSLSWSPNGFQLASGSADNTVRIWDMRNLRSIYTIAAHRSLVSDVKYYRGSPQIAGSMETDTIDQAGQYLVTGGYDGSVKIWAADDYKLIKSLEGHEGKVMGIDVSDDGKYIVSAGYDRTFKFWADENMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKU8</accession>
    <name>A0A8H7UKU8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKU8"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="142"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2182559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="494" mass="56365" checksum="01E707DD155B2515" modified="2022-01-19" version="1">MESEYHLRKLKADLAKQTLSSMHQLIETHAADFDLDKLIYSLKPEAANQEKVNPEDTKDMGNSYERLYKQTKDRYEKCGVEFDNHWHWTITWRQAISYKSLGTLYGVENIIKYTHPRAQKAVNQIFQDDLSQYMRWYPWRWFSDMQFIGCGGFSAVYSANLKLPFIPVNNVLKVGLKIVDDKVLNEASTRHVFYYPSSSSALPIAVQSRAFLALLFSGVTVCETTGDLMMVMTFAQDGNLEDHFQQDPMGDLDLKTITGTITRIAINIASLHDEIGMCHRNIHPRNVICAEEDYFLVDYRFSTASNEATTVTQTAKAHYGRLPFIAPEVRDGIYTEKSDIYSLGIIIWQLVAKVVFPSPEIMLANPDVYRIEPVPGIPKWYEALYTACLEPNPANRPDADEICSIVRSHNEDMPDKCPLPEETLQYVADRRKACDEHLTKTAVSIPGSNNPRTSTTRVYTLASLPPTDELVRLQFTNKPFDMASYEIDDEDDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7ULM9</accession>
    <name>A0A8H7ULM9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cation efflux protein cytoplasmic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_002760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7ULM9"/>
    <dbReference type="OrthoDB" id="435980at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF15">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="6">
        <location>
            <begin position="69"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="6">
        <location>
            <begin position="210"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="7">
        <location>
            <begin position="312"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2186322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="42218" checksum="FBBE70689D814689" modified="2022-01-19" version="1">MSIARAIVRRSLGQRCLALQTTRTPSLTYLPYRRTHYTEHGHGHDHGHAHAHLMQTLTESGKRGTRITVIGLAANVGLTVSKGVAGWMLNSAALLADAGHSLSDMLSDFVTLYTYKKSRRPADNLYPYGYGKYETIGSLGVSTLLIGGALGIGWHSAELLLNVLQTPGVNESVSTAVATVVDPTTSPAVAETATHKVAAVTDHHGHALNPNAAWFALISIVVKEWLYRATIKVGLEEKSDVLIANAWHHRSDAYSSVVALAAIGGSYAGIPVLDPLGGLAVSALILKSGGDVMVSSLRELVDGSVDRTMLDDVEKAILQAKASNPDIVTYQSLRGRKTGPFYLLDMALHVNPKLNVVQAHELEEKVRRHIQHSCPEVKEIMIHVHAEPSPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UM13</accession>
    <name>A0A8H7UM13_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UM13"/>
    <dbReference type="OrthoDB" id="2437812at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034654672" evidence="2">
        <location>
            <begin position="23"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2184718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="279" mass="31047" checksum="B4258D0BC92A075A" modified="2022-01-19" version="1">MQAIAFLLTLLLPVVLIYFIRSESKPDSLQSPTAKKKKKPKKKTSKRSESSTQSSPAVKSDEPDREPQSPVEKSVDTKALEAVTDDEDSAAELEETTEKSETFVEVKRKKEVNDSQVSRMTIDDDLDGTSRYSRVMRIKTDEPVSRQGLEPLEPGWNRAASKRNVSLWVNNARNVSQGGASPNSYEILTKKQRENQAKALKKKEDKAARQTEQDARLRQHKRELEKHKINDFYSKGAGKKLTAPSSVWASSSGSPGSPGSGKRPQGVASLNEHGQLIWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UNH9</accession>
    <name>A0A8H7UNH9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_002701</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UNH9"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000059">
        <property type="entry name" value="N-ethylmaleimide reductase, FMN-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2186263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="376" mass="41082" checksum="2B6C63A47B99DC2D" modified="2022-01-19" version="1">MSGKGLFQPIRIGKHLLKHRVALAPLTRLRAPPQTHVPSEDIVNYYTQRAGNGGGLLITEATLISPMAGGMPGAPGIWTKEQIENWKKVTKAAHDRGAVIFSQLWHVGRATNSFLLPDKAQPVSASAIAIEGNDMMGNPQQVPRALETSEIPGLIKDFVKAAENAIEAGFDGVEVHGANGYIIDQFINTNSNKRTDQYGGSIENRTRLALEVVDAVQKAIGADRTAIRLSPWGTFQSMGDDTPTETWGYLVQQLQDNHPELAYLHFVEPRTTLEDVAGTSVYSLDHFRKIWKSVFISAGGYGHDLPGALKHAEETGDIIAFGRQFIANPDLPQRLQQQLPLNPYDRGTFYGGGSKGYTDYPTYEETQTASEATVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UNN0</accession>
    <name>A0A8H7UNN0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UNN0"/>
    <dbReference type="OrthoDB" id="5600582at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="316"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2186428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="690" mass="76440" checksum="1E9C9C98923D2DB2" modified="2022-01-19" version="1">MSLEFQSLEYFAGDLDSPNQFTHNVVQNLVDRTGQPPAVRVGGDTQDRTYYHPSVLAVRLHPGSASVPNPNKCKYMWVLISSNEAMAIMNAFPGGKAGDVILERLEIGNEPDDYGYFEGSIDYAARWTEFAQNISQALNLSPGQGPHIQAGDYGGYSTNSTLTDLLKTNIVSGVTGARINTVAQHNYMGDGATGTIQILLDKALVRSMPGIFKPDIAYANSKGYNYILGVCNSFYNGGATNASNTGATAVWATDYSLQAASLNITRTYYHNNIATGYEHYYPSAYNIWEPVGNVIVGNITTAKPQIQPQYHAFLVVAEAIVRMVVINQEPWTFAGTGARPVTTVQLQGLNRKSATYKSLYVPYADVVDGMTWAGQNFTTDSGLPSGNVASQKVIGFDLQKTARTFSKPEQNLTIYRMDRHPPYPGRGGYDDRYKGYPPRPRGDSHRPHDGYRDPMYRDRDGGRGYPPYMRSPPRRPGDSGRPYRDHSPPPPSMRSRYRSRSPPPPLPPYRSPPPYRERSYYPPPPSGYRPPYHPRSSSPYNRRQNSAGSAVGSSRPYPGPGPQTMIPLPDSEHPPFRGPPGPPPPPPPSHHSSRPNSPGPYGGPPLSPHPRPRVSIAPIQEKEIRRHEEEARKLQAEELVTIGTMRKKTQDLMLAAWEVDKAEHQLELVQRQWEEGNLDSILEQPLSLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCI2</accession>
    <name>A0A8H7PCI2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_002925</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000022">
        <property type="protein sequence ID" value="KAG2171303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCI2"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000115">
        <property type="entry name" value="High-affinity glucose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF17">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="20"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="498"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2171303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="513" mass="55913" checksum="B29727EDCF717E61" modified="2022-01-19" version="1">MLGLKKPENEAGSSVPAILMGAFVAFGGVLYGYDTGTISGILAMKEFVNQYGAMDSSTGELAISSSTSSLVVSILSAGTFFGALMAGPIGDILGRRYGLIFATFIVFNFGIILQMASSSIPLFVAGRFFAGLGVGILSSLVPCYQSETLPKWIRGTVVACYQLAITIGLLIASIVNNSTQYRDDSGAYRIPIGVQFAWGLIITIGMLILPETPRYLIKRGNMEAAALSLSRLRKLPADHPQVKQELEEIRASHEYEMSLGKASYADLFSNDGHLRKRLITGCLLQMLQQLAGINFIFYYGTTFFKQSGFSQPFLIQLITNLVNVVSTFPGLYLVEKWGRRPLLLFGAVGMCICQFIISAVGVASHTEAASQALIAFVCIYIFFFAASWGPVAWVVTGEIFPLKVRSKGLSITTASNWLMNWAIAFATPYIVDSGPGNANLGVKVFFIWGSACFLCAGFTYFLIYETKNMTLEQVDELYDQVSKAWRSPGYVPSVQHSDQTHEEKPSDSPEDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCL5</accession>
    <name>A0A8H7PCL5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisome assembly protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peroxin-12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">INT43_009094</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">WA0000067209</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCL5"/>
    <dbReference type="OrthoDB" id="107372at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16451">
        <property type="entry name" value="mRING_PEX12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017375">
        <property type="entry name" value="PEX12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888:SF0">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038074">
        <property type="entry name" value="Peroxisome_assembly_p12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="331"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG2171433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="389" mass="44031" checksum="CCC39AF489D0FF89" modified="2022-01-19" version="1" fragment="single">MEFMSAMGSQEDAYRPSLFELIAQEKLREMLQPAVQYVLAVYAQRYPRFLIRIVNRHEEFYAGLMLLIERHYLKEWGASFAENFYGLKRVATNTATTGQFVAPANAQSSPKLSSKDINRSLMFLVGLPYIKCKLDLLYEQVSGGASASLLGENEQEIREIEILNNPSASVRTKAVVHLKRLFRKVYPVINMLYYGSNLCYNIGYLFGKTKYYTPWLRILGIEVKRMSMDDYRAHYEKSMIGGSSFKPTTVAGRSTHFLGTVLSKLIEFLKVLLPMSIFFFKFLEWWYSSEFARGGGRSGAYGDEEANIIPPPEEIKPDPRGVAVPKTPNTCPICLANPINNPTALPTGYVFCYTCAYRYVEDHGKCPVTWNKIRGGTEQLTKVYSGSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PCT7</accession>
    <name>A0A8H7PCT7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">alpha-D-xyloside xylohydrolase</fullName>
            <ecNumber evidence="5">3.2.1.177</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_008279</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Hydrolysis of terminal, non-reducing alpha-D-xylose residues with release of alpha-D-xylose.</text>
            <dbReference type="EC" id="3.2.1.177"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.177" evidence="5"/>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PCT7"/>
    <dbReference type="OrthoDB" id="1334205at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061634">
        <property type="term" value="F:alpha-D-xyloside xylohydrolase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06593">
        <property type="entry name" value="GH31_xylosidase_YicI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000053">
        <property type="entry name" value="Alpha-xylosidase YicI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007940">
        <property type="entry name" value="PRK10658.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF4">
        <property type="entry name" value="MYOGENESIS-REGULATING GLYCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117125">
        <property type="entry name" value="Putative glucosidase YicI, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="8">
        <location>
            <begin position="80"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="7">
        <location>
            <begin position="288"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="9">
        <location>
            <begin position="619"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00052064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2171553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="783" mass="87867" checksum="4F34408600A456B0" modified="2022-01-19" version="1">MKFTDGCWRDKTDVTFSHAIETVPGSIAIKGDNKEVLRALCTTKHTKHRGDTLNRPTVTLESYSPAKDVIATKATHFIARNRAYKQVEVHKSENVKADIKIEETSCNISSGGLTAKLSTEPSSFKISYSGSENELLTEALDVSWIQAKSDLYEGMKATQSFVNPADTESTIQVRNHMSVLLSLAPGEYVYGLGERFGPWIKNGQSIDTWNEDGGTSSGIAYKNVPFYMTNKGYGVFFNHSEAVSFEVQSEKMSGVQASIQGESITWYVIYGPTPAAILEKYTALLGRPGLPPQWSFGLWLSTSFVTNYDEKTVTGFLDGMKDRDIPLSVFHFDCFWMKPYRWCDFEFDGDYFPDPKSFLDNLHKRGLKVCVWINSWIGQESGIFEEADEQGFLVKRLDGTSFQSDDWQAGKGVVDFTNPDACKWFQSKLEHLMDLGVDTFKTDFGERIVWKGVKYHDGSDPVQMHNQYTQLYNKCVWEVLERRRGKGEACLFARSAAAGGQQFPVHWGGDSDTSWFSMAETLRAGLSLAVSGFGFWSHDIAGFKTGSGNDFTNPVGAIYKRWVQFGLLSSHSRLHGSSSYRVPWIIDDEACVVLEKFVKLKMRLMPYLWRESVRANKSGTPLMRPMFWEFPQDRSVWPLDQQYMLGPSLLIAPIFNDTGDVEYYVPEGTWVGLLDGKKRVGPRWVKENHDFMSLPILLRENHVVVLGSDDSKPEYDYTQDFTVVVGSKDVDATTAIVDAGGKECVIIKVSQGTVQAENANSGWKTQILGSEEQPASGSKVELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD21</accession>
    <name>A0A8H7PD21_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_008068</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD21"/>
    <dbReference type="OrthoDB" id="525520at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000001">
        <property type="entry name" value="30S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_uS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2171688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14270" checksum="3F8A5341F2D52C1C" modified="2022-01-19" version="1">MLHLLGVNLPDRKLVSTALQYFYGIGSTTSNKICDQLSIHKQCKLVELSEAQINSLSNVLANMNIETDLKRQVREHVMHHRSINTYVGRRHAMSLPVRGQRTRNNAKNAKKLNGRWVQRRMFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD28</accession>
    <name>A0A8H7PD28_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GCF C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_009121</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GCF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD28"/>
    <dbReference type="OrthoDB" id="429427at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012890">
        <property type="entry name" value="GCFC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022783">
        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028211">
        <property type="entry name" value="Ntr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214">
        <property type="entry name" value="GC-RICH SEQUENCE DNA-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214:SF0">
        <property type="entry name" value="LD29489P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07842">
        <property type="entry name" value="GCFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15458">
        <property type="entry name" value="NTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GCF C-terminal" evidence="5">
        <location>
            <begin position="523"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="435"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2171460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="745" mass="85033" checksum="5893AA2449372F78" modified="2022-01-19" version="1">MDTRSVPKFRDLPHSTLMFKKPSKAKAIRRKIETDDADDQEQGTEETVVQRTNLKKKKGGSAKKSLGLSFDEEQDGDGEVFQVQKSKASKRLGEQKTLHVPSLEPPEDMNQIDISAKNASPYSTEMLQQLRQSTPSTPKALVDAGLAQDDDALLMATKFPATLGARLGGASIPDANAIHAAKKKRELMRQGVTITDDDYVPLNDDEAEGQSRLVREEDEDGDGDDEYEKYVGERLILGKKARRQQEDKRKAGVREMIEEAEDDDSELDEIDRWEQEMIKYGGVRAKKTDESESSEINRNYRPAPIPEQTAISSISDVLSRLSLVSSNLEESKVNHDKQLTQTLKDIENLKSSRELTDSELERTSKRYNYFQELKAYVNDLAEFLDAKFPELEKVEQQFYGLMNQRTKAVEERRWQDDLDDVELFAQVPSQFIATQDDKEDGLDEYGRAKSSRNSAASKRRRLEERSSRHILRETSDEITGMSTDDELPESYAREEREELDEIQRDKINAIIADVQDDFASLISVKNKFETWKTEFNDDYAKAYGGLSLPGAFEFYVRIELITWNPFLRQVDFDTMRWHTIISEYGASGEEHEDDADDSDATILNKVVEKTVCKKIRDMIPNLDVFSSAQMKSARHAFEQVSYYVEDTEPAYKELQSTTMEHFARIVTQYVDLVAAITMKDQLDDAAQKARSRLLKRMIKLYKTLLPWKRLLSPVDPQAKLYAPLYEKALSRLAFPSDGELSSLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PD41</accession>
    <name>A0A8H7PD41_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_008097</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PD41"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08192">
        <property type="entry name" value="MAR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF107">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06800)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="2">
        <location>
            <begin position="32"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="3">
        <location>
            <begin position="218"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2171717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="46003" checksum="CF4AD0707AB82C6E" modified="2022-01-19" version="1">MANSRETYRLAFPDHENPPYTHVSYGIPFTEACAKHVSQTFNAKKAYIIASRSLSKQTSHVKDLEQALGSRYCATWNGISPHTPFDELVPIINDMREKDADCLITLGGGSLTDGAKIIIYALANNVHSMDDLRTMFEQTEKDRKAKNEFRDRTTGNDPTVPIICIPTTLSAGEYSKFGGGTDPKTQQKTILVHDKCYPSLVILDAELCITTPEWVWLSTGVRAIDHSTESLCSLMAVPEVDAAAEKALKLMLPNLLKTKQNPNDLDARLQCQLAANYTLVALLYAPEKLLAGGSHGIGHQLGPLGVGHGQTSCILLPAVMKYNKSVNADKQQKVKEILWSDKVVVGILKDAGLTKENSDAGDALGAVFKALGMPRTLKEVGVGRDKLDILADNSTRDPCCVANAIPLTKKEQVMEILEMVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDE2</accession>
    <name>A0A8H7PDE2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_008366</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDE2"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="9"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2171640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="283" mass="31653" checksum="C6892B8D47E41EB7" modified="2022-01-19" version="1">MQTRTIMSKNTILVTTATGNVGGHIVTLLLEQGFNVNALVRNPDSEAAQKLKAQGVTLFKGDFDDVPSIEAAAEGVYGVFINTVPNFANMDEYKHNSNIITAAKKAGAKIAVYMSVDVQEAGFDHWTIIRPAMFLSNFHTRLASYMWPLLQKEHKFVYSPLDLNYVFSVVDTLDVGKFCAAPFWDTKTFDKQMIDLRTEDVALSKLAEIMTKATGIPINAELVSREEAKTKGVPDAAYQWEDWQVATGYKIDTERLKSFPIKLSSTEAYFDRNKDKAIQFLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDR4</accession>
    <name>A0A8H7PDR4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_001508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2172031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDR4"/>
    <dbReference type="OrthoDB" id="436519at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029827">
        <property type="entry name" value="JDP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44500">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44500:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2172031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="157" mass="17908" checksum="4ADC327562A6235D" modified="2022-01-19" version="1">MDASKPGNRNLFYEQLNCVPESNLDQIRAEYRKLVLRFHPDKAATGSEGKYKTMPAYEILSDSSKRAIYDRWRTSTLQIPFDVFQGLGSHAQTLHWQSLPSQQTITINSEGNSENIPHDAQVNQSIPLADGRTVQIGSAWKKNNSDELYSQFRNYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDS3</accession>
    <name>A0A8H7PDS3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">INT43_008215</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Nucleus</location>
            <location evidence="16">Nuclear body</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000019">
        <property type="protein sequence ID" value="KAG2171835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDS3"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16450">
        <property type="entry name" value="mRING-C3HGC3_RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037381">
        <property type="entry name" value="RFWD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056527">
        <property type="entry name" value="WD40_RFWD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047">
        <property type="entry name" value="RFWD3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23419">
        <property type="entry name" value="WD40_RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0853">WD repeat</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="86"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG2171835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="552" mass="61821" checksum="8FA9E9C2FE07B224" modified="2022-01-19" version="1">MPPCQPLTTNNPEMPAETESTESSGEQPGASVSNLVANVATTSTIHSDRITNSSDFQSPLTLTSKRKREPSTQVSDSDDDEAICQCPICFENWSNTGAHRIVSMKCGHLFGLSCIEKWISRSRKDVKSKCPQCNAGISKRDIRPVWAKKITSEDSVKLDKLQEELRTQQARQLDHEVALSKLHLAYEMSKNELTKKDAEIQLLKLMLSDTSNNSNVSRRLPSTSLSLIDQLQMKQKLSFHSSARVCRVMAFNQGFDMIVASKSSSASEHAIQKISLVDNLNLETMTIHSRGIRDIQCSRSGLCLTTGLDGKANITSLKDNCIVQSYNLGTAGWCCSWDQSDANRLYCGLMDDSVMMFDVRNTRSYVHHLKDHTKTNRKPIHSIIHIGGPTNSVLCANLDRLYTWNLAGDEPYCSVIDMDYQDFHPYSVSYDKSSMTILASLRSQTATKHVHGSLANNQFETQNTYRNPIKQTALARTWHFSKPRSSENSNTSTEFVVCAGDEEQKSLRLWNDEYGERSIHVGSDILDIKNTVINNEVYLAALTGNEMYLYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PE37</accession>
    <name>A0A8H7PE37_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xylose isomerase-like TIM barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PE37"/>
    <dbReference type="OrthoDB" id="2307048at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF21">
        <property type="entry name" value="XYLOSE ISOMERASE-LIKE TIM BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="29"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2171964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="349" mass="39284" checksum="01B46358681DFD6C" modified="2022-01-19" version="1">MKTIQGPAIFVAQYLGDKPPFDNLDNIAKWASELGYVGIQIPVDNRLIDIEQAANSVSYCNEIKERLAKFNIVITELSTHLQGQLVAVHPAYNSLFDGFAADKVKGDPEARRQWAVEQLKLAATASRNLGLITHVTFSGALAWPYIYPWPQRPAELVEVAFDELAKRWLPILDEFDAAGVDVCYELHPGEDLHDGVTFERFLEGVNNHRRANILYDPSHFVLQQLDYLAFIDIYHERIKAFHVKDAEFRPNGRQGMYGGYSTWADRAGRFRALGDGQIDFNGIFSKLAQYDYAGWAVLESECALKDPEVCAEEGVPFIKSHIIRVTDHAFDDFADSGTSKDQIKNMLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PEQ6</accession>
    <name>A0A8H7PEQ6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_004836</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family. Monothiol subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PEQ6"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02066">
        <property type="entry name" value="GRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02984">
        <property type="entry name" value="TRX_PICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000012">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000092">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF73">
        <property type="entry name" value="GLUTAREDOXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2172294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="312" mass="34625" checksum="6E46B1B6B7A6BC9B" modified="2022-01-19" version="1">MSNLIELSSEEKFQQLVAGNAPVVLNFWASWAEPCSQMNEVFKELANKFPTLKFIQIEAENFPETSEKFEIESVPTFLIVKNDKVVNKIEGAKAAELSNAVAKYAKGVLANNTSINGVSGAPPPVRDLQSRLKALVNSAPVMIFIKGTPQQPRCGFSRQLVDLLAEQNVRYSSFNILADEDVYINGELAGGLDIIKELIASGEFAEMVPKEKDLSSRLQELIEKQPVMVFIKGTPQEPRCGFSRQMVGLLNDRHVKYGHFDILSDDEVRQGLKAHVDWPTFPMLFYKGELLGGLDIVKEMIASGEFDQVVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PER5</accession>
    <name>A0A8H7PER5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_004872</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PER5"/>
    <dbReference type="OrthoDB" id="248120at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000003">
        <property type="entry name" value="Prefoldin subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2172330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15997" checksum="28D819DCAEA5F623" modified="2022-01-19" version="1" fragment="single">FLLSYTTACYIMSAQALEAKLEVESKAFQQIQKDLTKAIESRQQLDSQRQENELVKGEFDLLDESAGIFKLVGPVLVKQDRTEAFTNVKNRLDLINAEIKRVEAQLQDLNQKSEKKKTEVGYEQIIMQLQSQFQELRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PG10</accession>
    <name>A0A8H7PG10_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PG10"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="200"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2173276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="447" mass="50893" checksum="ACE366B156D11F92" modified="2022-01-19" version="1">MQKPNAYDTITIKPHEDTNSILQLLENVDINDLTYQDEESQDLVELGDEFSFKKEYQQAKFWWEKAAGKGSARAYLRLAYYYRSVEWDYNKSVENFKVAAKAGNVKAQCHVGDLCYASSNYKMAVEWFERAAEAGSRYAQQKLGDIYYKGIGVEKDLKVAAEWYYKHASKQGDKRIRRSNSIRSDQVIYKASKKITSLLIYIIFYSLSDQIYTLAKEVRQGLESQGVKVKMFQIPDTFSKNISSHMNARSKKDIPLVTVNDLKLADGIIWGVPIRFGSMPVQIKAFLDDTSRLWKSKSLAGKFTGMFFSNTNQHDGQETTAFTALANFYRHGMLYVPLILADSGLHDKLEALSGSIYGPRTIENDQNAHEPTREELKIARQHGETFAKVVKTYHWGAYYEKEISSLGAQENNSKVSGHNGRISDTERKVLLSALELGSSNFSFNFNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PH31</accession>
    <name>A0A8H7PH31_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein AF-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_005228</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PH31"/>
    <dbReference type="OrthoDB" id="16041at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16908">
        <property type="entry name" value="YEATS_Yaf9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573:SF1">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2173808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="210" mass="24302" checksum="6852E466CEFF51B2" modified="2022-01-19" version="1">MKGTVATRALYYGNVATPLGGKKASDSDHTHKWTILVRGVNNEDISFWIKKVTFRLHETYPNPQRTIEQPPFEVTETGWGEFEIAIKIYFHTASGEKPVTLYHHLRLHPYEDDGTGQPWPKDKPVTSFNYDEIVFNEPTEAFYQILQENNATSIQLPTKKSTKDPPVPFSTMVEQEELDRLDKSLREVNRQMQKERQRAEAITEEAAMYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PH73</accession>
    <name>A0A8H7PH73_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_004580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PH73"/>
    <dbReference type="OrthoDB" id="190958at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="211"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2173206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="335" mass="38772" checksum="0E627C7F796C545E" modified="2022-01-19" version="1">MPLCDKQAGLDLLTTSTFAFCLSESIDKLFVIMANRTVTEASTVHGTNPQFLIEKILREKITDSLYWKEHCFALTAATVLDKAVDLQGIGGSYANHKPTEFLCLTLKLLQLQPEKEIVIEYIRNEDFKYLRALGAFYLRLVGNAKEIYQYLEPLLNDYRKLRLQEEGGNTIVHMDEFIDQLLREERVCDTILPRLTKRDILEDVEDLPPRKSVLESDDEANALSDEERRSRSPSQHSRSPSPRKSRYRSPSSSRSRSRSRTPPRPSRRYRSPDSNRSRSGSRARSYSRSPSPRHRGRKDRYRSPSGSRSRSRSRSRSPERSRRYYSPPSPGSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PHX2</accession>
    <name>A0A8H7PHX2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_004125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PHX2"/>
    <dbReference type="OrthoDB" id="27237at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="583"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="583"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2174105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="725" mass="82933" checksum="E80E5FE19EACEE2D" modified="2022-01-19" version="1">MESLQDIFDRSATETEDYVKYFIYFPEDTSSIENLEQICAEIQDLVQQLTGDYIWYKDRFGISMTKSSIRDPAYTFLHGITRFGDCLNDEWLIVYILRQISKRYDDVVIAVNDNDGDFLLIEAAMELPSWLDPSNSDNRVYIYQGELHIIPLPKSPAEILHIPSGKISRSRAVQIIRSNMVSTRAAQNVQEAAFFRLKGYPAKAAEEKHRALCTIPRKLAYILLKHPQIIPRAVEAFYLRDPSSMRASARMEKFPPADRVTTVVDMTKTSYAQLVSQKFHAPKSFTMPPRSNKRTYAAADLGMRITCAFEMLYADKRINREHPGQNVTVEEYDFTNDKKWNAFKKKLLQRGFFKGELEGSQRYRQLELVAKQQHLNHLQQEVKNVDEEADLEDMEEVITNSPLNHIPRKEIDLLLNEYSDDEVEKVLQAAESKTEDDDSWMDVDPKQLEELLKQYGSLNMDDMNPNMAKQEDGSGLDLEAMMKKFEDFVNYEQSGLEGAEFPMEETIQGSDNEGSEEDKERGKEFDDDDDDDDEYESENDEISFDPNQFLDTLKDILGNYLTGETRKLVIQILIILFSKGVAPQQTSEASSTSNYLGKADTQEAKLQEISDEEAQKIRQGNPTDDMSLERAFEQMDAELHGHQKINASFQKSVRFQSEHGADSDEGTDYIEDEDAPVDIQLNLVKNMLDSFKSQEGLPGPIGTIMNRMGVVMPRDDSDAETLQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJ40</accession>
    <name>A0A8H7PJ40_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_005965</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJ40"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000005">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="7">
        <location>
            <begin position="110"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2174903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="307" mass="34802" checksum="21AEEC70601B177A" modified="2022-01-19" version="1">MGSSDLDRQIEQLRQCEIITENEVKILCQKAREILAEESNVQKIDAPVTICGDIHGQFYDLKELFKVGGECPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGSVNVWRYCCEVFDHLALSAIIDNKIFCVHGGLSPSVNTIDQIRTIDRKVEVPHDGAMCDLLWSDPDDIEGWGLSPRGAGYLFGGDVVQSFLHNNDLNLIARAHQLVMEGYKLLFNDTIVTVWSAPNYCYRCGNVAAILELNDKLESNYKIFEAAVGVDSRGAGVRKRAPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJ92</accession>
    <name>A0A8H7PJ92_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycosyltransferase family 49 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_006039</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJ92"/>
    <dbReference type="OrthoDB" id="3056235at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042285">
        <property type="term" value="F:xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051292">
        <property type="entry name" value="Xyl/GlcA_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270:SF25">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-LIKE PROTEIN LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2174977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="62136" checksum="3B5A9D5FC08BCB6D" modified="2022-01-19" version="1">MSSDVPHSSLQPNGRKKGSHKRNSSTSTSITTNATSTHHRKPSYTSKNSSSYLNMPINFKSLDSIVQSPDEPQGYMPQLVLPSESSDDSPPQSSTPSKRERYQAYFQSYSRPSNTTNTHNSKPLTPLSTTPSLSFRLPTFLRYRWLRFLLFIYAIFSVCVTFIHLFQWSFNQWPEVSEDFAAVSNYSYMTEMSDTLKFSKLFSDQMPQNLENITPYFLRATRDPGEYDVTMLTVVTEQTADHLVDLAETWQGPVSAVLHIESTSHMPPDTTAFLFQMRHLHESNPSMRAHMDIHLIITPPRENTKFSLPMNQDRNLARLFARSEFIVYVDSDVMHISDLANTLASKREQYRDFLLKGDVLVIPSFIHITDEEEGIPQDKNTVVAMIEAGELALYDMHHDLNLGPTSLADWKESVTMYPVGNKYNYHYSPVAIMSRNIHPWCPERFVDNLASCFLGTQLSGASFWVLPDDYVIQSPILKEYQLSQAEIEREKLLYGRYIPEMCVHYARKLVSLDLWSSSRASRIKNWVGCHSSRKTWRSLTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PJD0</accession>
    <name>A0A8H7PJD0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_006048</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000012">
        <property type="protein sequence ID" value="KAG2174986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PJD0"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000162">
        <property type="entry name" value="Glutathione S-transferase Gst3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="170"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="143"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2174986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="323" mass="37626" checksum="8BA58ACAD54872F3" modified="2022-01-19" version="1">MSTTATKQQPEITKWASKDGEFRRQVSSFRDFVSRDKNARFAAEPDRYHLYISWACPWAHRTAIVRQLKGLDKIIGLSVVDFLLLDKGWKFSSSEETPGAIPDNVNNANYIREIYFKANPDYEGRFTVPVLWDKKNATIVSNESSEIIRMFNEEFNDYIDEDKKSLNYYPENLRKDIDELNEWVYDTVNNGVYKSGFATKQTAYENHVYPLFKSLDRIEKILAENEYLVANTFTEADIRLWTTIVRFDPVYVGHFKCNLKTIEKDYPNILRWARQIYQKAGVADTVNMHHIKHHYYESHSQINPTGVVPVSNGPDLSKPIIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PK28</accession>
    <name>A0A8H7PK28_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PK28"/>
    <dbReference type="OrthoDB" id="2310186at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="95" mass="10639" checksum="3615FBE6F80B3D01" modified="2022-01-19" version="1">MSSLLQKVAFWYSSQLHFIQLSCMILIFYPISTVVPIVTVVGYSRVVNAESAMSHPQRFISTSGDKEALELVRSEWKVRNHGIGLRDVRRSGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PKJ0</accession>
    <name>A0A8H7PKJ0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPI inositol-deacylase</fullName>
            <ecNumber evidence="10">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_001330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="10"/>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PKJ0"/>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="11">
        <location>
            <begin position="38"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2175683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="323" mass="36236" checksum="DF223D77A64EE43D" modified="2022-01-19" version="1" fragment="single">MRPNFVKQSNFDSEMTRFAGKYTLYLYREKAIDFSDQPTGVPVLFIPGHAGSYKQVRSIAAEAAYRFYGQNGRPHRNWDRGQQNLDVFTVDFNEEFSALHGQSILEQAEYLNDAIDYILKLYPQARKNDGRLNLSLPDPQSVIIIGHSMGGVVARVMLTIDNYQPGSINTIITLSTPHISPPVPFDWMISKIYKDIHQFWIDGYSTAVNDRRRSLRDVSLISIAGGNLDSIVCSDSANIGAIVPATHGFTVFTTAVPNVWTGSDHPAILWCNQIVGVVAQTLIDIVDVRRAGQTKPLDARMQVFRSAYLSGLEHDRRSRDIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PL85</accession>
    <name>A0A8H7PL85_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_005335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PL85"/>
    <dbReference type="OrthoDB" id="268693at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018263">
        <property type="entry name" value="Ribosomal_eL32_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00580">
        <property type="entry name" value="RIBOSOMAL_L32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2176102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="15219" checksum="83A666AF96EB9C75" modified="2022-01-19" version="1" fragment="single">NMVTPAVKHTIVKKRTAHFKRHQSNRFMRVGESWRKPKGIDSRVRRRFKGQAPMPKIGYGSAKKTRHLLPNGFRKFPVSNLKELELLLMHNRTYAAEIAHNVSSKNRIAILERAAQLNVKVVNANARVRSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLH5</accession>
    <name>A0A8H7PLH5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLH5"/>
    <dbReference type="OrthoDB" id="5596457at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2176247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="301" mass="34399" checksum="448B4C7EF79FD342" modified="2022-01-19" version="1">MSPALNHFHKLKRSLTSKGARSQSHKNSTCSEPPAVQNVSYVKPTTTNISPPHQSSNFVNTLRTISLEAGRRQYGDVYDVFFYQDKKCRDRAIFLACRLRQTYDVLFHWSPEYSKDDFIVAVCSRLYAYNYILYALPQQSPTRTQFLSKLDQQCQSLGIVGAGNREAVFSVGHCLRKMEGYIDADVVERARQTLSKCLESEDKLSHDERGSMYIFHGMMSGMNWDARDLDVTVEEAGQITQDILQVRLSLLAKPEPYQNPFEDASAVVEEDDDDDILFDREPTNSHKKVDSGFYDGYTDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLP1</accession>
    <name>A0A8H7PLP1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_005586</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLP1"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2176352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="259" mass="29044" checksum="8F817E46AB550516" modified="2022-01-19" version="1">MPKTTSRHKQRSDGASGRSKQKLFQCTGFGDCNMVFTRSEHLARHARKHTGEKPFKCVVEGCDRMFSRFDNMMQHTQTHSHDRTTKKNREKFTDEVSPSERKQPSRSGPPPPLQTTMLTPPHTHERLPSSKENTVVNSWHSLPELPISPVSPTYNSWSAAPGTKPVSFYHCSPTSQHSPASLVRSASPASSVPSMDEPLSPSPTPNTKPDRRLSVAEICNPVNKTPTVERAMFLPLEDHIALTQDEYEALQGFTRFQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLV8</accession>
    <name>A0A8H7PLV8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000011">
        <property type="protein sequence ID" value="KAG2175606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLV8"/>
    <dbReference type="OrthoDB" id="10314591at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2175606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="72" mass="7820" checksum="6CE1FDD929493B75" modified="2022-01-19" version="1">MLFSNMSNRSNKVQTATKTTSDPSVSKLATSKYNNDPVRTTNTPDTPKDFVNPMGGQAFLQSKARDITHTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PLW5</accession>
    <name>A0A8H7PLW5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_005555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000010">
        <property type="protein sequence ID" value="KAG2176321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PLW5"/>
    <dbReference type="OrthoDB" id="1939603at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF3">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="306"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2176321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="358" mass="40172" checksum="FDC96C5ED9F6CF3E" modified="2022-01-19" version="1" fragment="single">MVQGGTESIPYPQPMTIPNYSGMMMDGYHAAHTIYPSTPVRSPQPIAKSHHQSSSNQMMYHPTATESPRSGYARRPTMNANYQVESHMPLTTATVASMNAQAAPSLPPLSQLLPASKAQHSHMQAVASSDPNATMVYSPPHQSNHAHPHPEAYEMSPAYIPMNDSYAQQTYNHATTDSPDSAPKGRILSPRVPTSPHTVPTMNPDMIPMQGGPGNQMAMHPLQAVDGMYAYHPMMANAPANYDGSMMPMPMEEPPHHVVYNQERHSYDSNSSTYSKRQKVFSFVSLPGINQPKRPRRRYDEIERLYHCNWAGCTKSYGTLNHLNAHVSMQKHGPKRQPTEFKELRKQWRRSKKERMQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PMP4</accession>
    <name>A0A8H7PMP4_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PMP4"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2177029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="69" mass="7835" checksum="7704090A61F6818A" modified="2022-01-19" version="1">MFCECRHSTGSCTSSGRAREQREGDITLSRPVKYKTAVHGIPRNISSYSNYLRDDKVSGPDNYRFLFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPG8</accession>
    <name>A0A8H7PPG8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_007550</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2176896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPG8"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="157"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="713"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2176896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="831" mass="92966" checksum="1190B4A3F6D29DA7" modified="2022-01-19" version="1">MPLPTQAPHISNLINNSYNQPGINQQRPPPQVNYNQSAFEQHPRQPNVLPYQQVMSSPAAAASEDSRSSKRVRVSRACDTCRRKKIRCDFDSMQGGQSCSTCMNSGWECTFNEVAKKRGPPKGYIDSLEDRLKKMERLLENIAQSGNASATAALKEGFGRSDSETSDAFHNDNDSQPSPVQSEQPLVHNVKAAESPQIKSPAKRPQSDSERNDCTPVPSNPEDILHSPASMIGTALENNKVCKYIGSSAGIHMLHPDGADKQEISFGTKKMFFQLDDKEHNGHLADRGAFVVRDQYDFEHARDLEAAQLEMQGALPPKDLIDVLVKTFFEHAMVNYPVISKKEFMDAFEGKTKPAPSRMLLNAIFCVACRHLNADHPVLKRYNLDPKRLFKLFTDRAAMAFTRQYFNPNVSTIQALLLVTTNPNYTPHGNPNWIWCGMAVRMAQDIGFHRCNGAFAVTPAQGDFAKRLWWTIYCNDRWTCAMWGRPLGISDADGDTEKPEVKTQEDETFVEYIKLSEIVGEVLRRLYSAKARSMAHGTKEVESVIEFLRGMLTEWRKNLPPRLNITEEELASMRARIDEPVTPDKAYAEKGPFMMYYLSVVILLNRPCINNGKHENEDESAQRCTEAAKSIIDVARFVCNDDIMHFGHTAALTVMQASFIHLYNAAKTTEEISAAALKYITIAMKRFESIWERWPGAPPVIDLVRKLQSSINKSIKKDTPSPPKNESKPVASNTENPEDAPPSNATADSSEPGMTPDQSNETPDENMFANWPIEQFVASLSDPAIGMVANPDTKQNTNIPFWGAPSGYDWQEWGNFLVESGTNNASTESIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PPS5</accession>
    <name>A0A8H7PPS5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_003437</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PPS5"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="25"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2178184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="507" mass="55442" checksum="83BD8B87ADA1CBBE" modified="2022-01-19" version="1">MATSNVAAGKTRGNFNKGMLTMYAYTAVAMVNSACNGYDGSLMGSINAMTQCCVVTAADGSTAPCGPTDSITGLIMSIISVGTIVATLFSGYLSDKYGRRWAMAIGSATVIVAAVLQSAAVHVAMICLGRFLLGIGSAICGVASPTLITEIAPARMRGRLTGTYNCFWYAGSLIAAGVTYGTLQINGTASFRVPLALQALPSLINLIFVWFISESPRWLIANGQKEKAWHLLVKLHGDGDENDPVCKAEFEEICETIEREKRTSKAGWKELVATPGNRYRMMLNICIGLFGQWSGNNLVSYYLPRVLSQAGITDSHTQLLINIFVNIWNFFCALTGTVLIDFLGRRIMTIFATGMACFWLMMICIFTALYGGTGEHGVAMVAFIFLFYGLFSIGWTPMQALYPVEVLSYPMRANGMAANAFFANIAQFVNQFCTPVAFTNIGWRFYIVYVVWDAFELFVVSKYFVETKGRTLEDLDHVFNKTTPHDVEYAEKPGSVSEDGKLPDEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQE7</accession>
    <name>A0A8H7PQE7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RhoGAP-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003253</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQE7"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13277">
        <property type="entry name" value="PH_Bem3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000452">
        <property type="entry name" value="Rho GTPase activator (Bem3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="237"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="372"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="750"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="486"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="610"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="978"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1053"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="610"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="645"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="684"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="720"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="991"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1064"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1085"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2178000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1095" mass="121960" checksum="D88462097BCF8221" modified="2022-01-19" version="1">MNKSATSSPDSLQGQNDQLWKIIEKQRLIIQNLQKDLTRMTAERDQFRSKCEEFEKKARLPTLSVNLPIDDDLESPSSPVPPPRSPYRQNTTKEQHAPSHLATADPLHAEDVELNAVPRDAIMESDAQLFTKYHQASTPRPSRDSMLPPARLLPEHDIALRAASPPPPRTMYRSPSPSEFMPPPPPPLAHDSIRDTMLSSDFDDLPIPIPQATNASKSLTPTTPSATSVFPGDLIAGICIKVTGSNITTNEKGKEVVSFVISVGKRVEYPSSDGMEDDMEELWRVEKLYSDFLALDTKIKSSEHRNISNRLGKLPDKALFATHAPSKVDQRKRALEQYLRLVISLPLKDVTDLCEFLSTNVIEQEPEPNRIPGHKEGYLTKRGKNFGGWKTRYFVLNGPVLRYYEAKDGHHLGSIRLTDAQIGRQQSQSNTFSEGADAHSVYRHAFLILEPKKSSANGVARHVLCADSDNDRDEWVEALLQYIGVPEDQAPPRTSRERDDRKKASKKTRKVSKDDIVPIASGPISQLKSDKHEKLLIPHGPLRTPSDSSIPKDDASSSPRTPGTPGTPSDILSSSVPTNSPLAQTATSDQQRASLDQNYSYFTHNIPTISRRSSMTQLQVRESDMSPQNESRSETSSPVAGGKSSSEHNEDLDSAEKKAKQKSNRMTFWGKKMFNSSNDQSPATLGTGPRPSTSTSTSTPGSAQSSGLRGFLTRSSNDSPTDRPGQHDKKKKGANDELPKRPSPNQVFGVPLEMAVKVSRPAENCDLPSVVFRCIEYLDAKDAASEEGIYRLSGSSAVIKGLKDRFNNGKLGELLRRWARREIGADGDFDILSSKQYYDVHAVAGLLKLWLRELPNSVLTKELLMDFLHTIDLLDRRDRVNELGRLVSMLPLANYTLLRALTAHLIRVVQNSDVNKMTMRNVGIVFSPTLGIPAGIFNLFLSEFDYIFWTNDDNSETKTPEEVQFLQQQEVFGAVQQQHLLQQQRRKQSHKQQDEDNHGVEEQNEAKPEQQPQQPLPAKPLGRTPTLRLIEQSGRNNRNSVNYMDGAPDAIVGLEKNLDSTPVLDEDDVEEINRDDDSDDDDSISIDSIDLSSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PQP7</accession>
    <name>A0A8H7PQP7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YMC020W-like alpha/beta hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PQP7"/>
    <dbReference type="OrthoDB" id="5598028at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058934">
        <property type="entry name" value="YMC020W-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058933">
        <property type="entry name" value="YMC020W-like_ab_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349:SF1">
        <property type="entry name" value="AER328WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26147">
        <property type="entry name" value="AB_HYDROLASE_YMC0-YMC35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YMC020W-like alpha/beta hydrolase" evidence="2">
        <location>
            <begin position="624"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2178150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1045" mass="113760" checksum="4707AF79F4ED62D6" modified="2022-01-19" version="1">MSLSWLSFSSTQEKTETTPSAAEIATSEPAKDDFDSGRDASYESPAAGRLKKATFTVESSSITASADDSSFDDSSSVLSEAKRSLSLNVKPPTSHTQSSGSPNPTEASKPSTTIASDSELFKKPQDIPVDSHTLGGSNKDQVKAIASPRISPLMKPRERTNSGASSNSAIWIHRLNATKATAATHSTGISVTGDIQPHFSPKVVSSLGDHDIDSHSMLTASPALSAIDRLTLQRSRSLDLKLENTRSSDEMSIPQDTKSTQIGGGAGGGNNDGGDGDDDNEDKKPQKGIDSAKVTDASAAGTEKLHEEKVNERPSGNEQDQKVTPELTNAIWSWFSKGNDTVPHKGNVLSEPTESAPTDVAQSVETEPPEMTLDQQDAPAKPSSSDVKLDKPSASANSSPNSTITNSGTQNSSSWGFLFGNSTSDKQSHGASTHKPVTQVDFSKPDNDNKKADGSSTSDGGQVPSGKPVSEKEKQSEPSPTKDEVNSLKRKSSITSVKSGTKSIVASPRAGPIKTEEEKSKNPIIIEKSTSQEKVHDTTGVTQSSDVNGGKSTSTRNVVLPSFNSQFKYTPTSEDLSNTTPTTLLNKALFAINGLFANKAQKNVDTAETSSRIKGMTQKMANFIQDMKLEPETVANKRFVIVGVHGWFPMKLVRSMIGEPTGTSLKFCEQMEKGLKQYFHSTHGINIPDDSITMIPLEGEGKVEDRVQRLYDALLESSLWLDAISSADVILWATHSQGTPVSSLLLKRLLQEGHIHMHRQQCCMLAMAGISQGPFPSLKGNLIVKYFEADAARELFEFMDSNSEISQKFRKSLTSNLRLGIRMVLVGSMQDQVVPLYSAIMSSASHSNLFRAIYIDGHIYNEDDFLINLIIFALRLRNAGVSDHGLLVHISEVLAGNLYALEGGHSTIYEEVEVYTIAARYLFETAPFGKMTIAACRPPVPKPTNLRPGRDIVKEGETYISPHAKQFPKEQNEEPEIEGFQARLRMNPFYLPWAMRGICDDARILNDKILNQELERLRSLFEKWNPISAKLREIKFRLEPLKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PR56</accession>
    <name>A0A8H7PR56_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_001618</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PR56"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024586">
        <property type="entry name" value="DnaJ-like_C11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055225">
        <property type="entry name" value="DNAJC11-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052243">
        <property type="entry name" value="Mito_inner_membrane_organizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11875">
        <property type="entry name" value="DnaJ-like_C11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22774">
        <property type="entry name" value="DNAJC11_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="37"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2178772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="585" mass="64832" checksum="B0E4E05062CD3458" modified="2022-01-19" version="1" fragment="single">MDPYEQTQSSASIPDEYVDEEEHLRELEAELAPKGADYYGILNISKEASEDQIKDSYKKLCRVFHPDKHTNEEKKRAAETQFQVIQKAYEVLVNPTKRILYDTYGESGLTAGNEIGPKLKTPEEMRAEYEKQARLKKEQDLENLVRSKGEFQINLNASQVFDPYDPPVLHGFGQAKKPQRKSPFDVLARAQVQQLFMKHSFETQVGPSTHAVLSGSMVSRGGMGGGNIIGTIRHTVSPRFWVEGGVGLLKPRALTFKTFFNVSSDSFINTVAQARTIYAPPILTVTAGRRIFAAATGYMTYRTGEWNLGDWGRGYGQGMDKSSISMGLAGQGKRKNYSCEIQTGIIASHIAVDYTYRMVDSTRIRVGGSLSTVGGLMASIGSDHKLTQHARFGMAMECGVPSGVVVKFKVTRLGQRVVIPIVMSGEFNIKLAFWGAVVPASVAVITDHFLLKPRRKKQLADKIQELREEHADYLAQRKTEAEQAQLILADSASRKTKAEEAKNGLVIVEARYGKGSDMIDVTVAIQALVHESKLTIPGGHAKSNILGFYDPCLGEAKQLIIKYRFQHRLHEVCVDDTAPVACPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PR94</accession>
    <name>A0A8H7PR94_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_003043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2177796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PR94"/>
    <dbReference type="OrthoDB" id="2413591at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2177796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="355" mass="42074" checksum="6ACFFBC857D8BB87" modified="2022-01-19" version="1">MTIDNIVSNATLSMVDDEHLVSDSPAERLANFHLVDIYGNLVEEDIDYFLEMYDQPENVLKLSNIMDNETLYATYRLNIADKIIVRYSIIDGMHYLTREKKYFQVCEEEDHEEEVIFADGLPEKKSRLEFHVTENNTFQIAEWNSDFWLEFYKRTVNYNDLKLNIDEDITKHRKPLELLLRKDPKEVFVPAEVNDNFEVQNSTDPLTRGANFQLLDIEGNPVEQKIDYCLEMWGVDEDVLNVSDVLYATEYQDNIDKMIVQCLIINGIHYLVSNNKYFQAAVDDDERQGQILLSTKLPKKVQRLQFQVTQFNTFKVVQWNQRTYLHAEQIDLQHTFFYFQDDECELDFFLKRCEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRM3</accession>
    <name>A0A8H7PRM3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="1">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_002054</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRM3"/>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2179204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="249" mass="28099" checksum="6997F11441AC0E12" modified="2022-01-19" version="1">MTKRKTALCFTGGKDCTLALHRTIESGQYDISLLVTFAPANMQKFKAHPLPIVQMQTQSLGIPHRVYLVEGPDFLGSYQKHITSIKEEYGIDALVTGKVLLYDGLDFNLAILTLFQGDILDVCHNFMPRAVEGTGVELIRPLWELPRSEILEDIWKHGFEVLISCLNVTKFDTDLDVETFVGKRLSKELLQKVRDHNEKFGRDVDLAGEFGEFHTMVLDAPLFKTKIDVSSGQIVRDGDFAYWSFSNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PRX3</accession>
    <name>A0A8H7PRX3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_001656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2178810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PRX3"/>
    <dbReference type="OrthoDB" id="2405379at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2178810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="227" mass="25393" checksum="CE47D689FDA8DA6A" modified="2022-01-19" version="1">MHQFQVLASTDVKGIKEQPPHSLETHCKNLELDPLPDNTEHIPQESICEYTNNVDNDNIPLPIEKLTSKNEFTVLSAEPESMDVDMSPSPVPLSQRRQAQDLRVLTDSKIVPPSPSLSTPLRHYRMPSSLRGSFSETTSARSPTTVIAPDFSLKRPLGRRHSTITIAAQRLEADARRKEVLVNKSPGSAIDKRAFGFEPIFGEWERRAKADKSVHTSPSYTKLNNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PS19</accession>
    <name>A0A8H7PS19_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HPt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_002082</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PS19"/>
    <dbReference type="OrthoDB" id="1673781at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043424">
        <property type="term" value="F:protein histidine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="entry name" value="HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045871">
        <property type="entry name" value="AHP1-5/YPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242:SF52">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="Histidine-containing phosphotransfer domain, HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="3">
        <location>
            <begin position="63"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2179232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="175" mass="19527" checksum="694B8FFCACE2818E" modified="2022-01-19" version="1">MSTVKSPQKVEENQKDEVRGTESAATKASPPAAAVDEPQEDNTEDLLDMATFDQLLDMDDEEDHEFSKSIVWDYFIQAEATFEDMDGALEKEDLSELSRLGHFLKGSSAAIGLKMVKATCEKIQNIGNLKDETGISAIDADQALKLIAPLLPLVKREYKEAKSHLEDFYEEQEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PS23</accession>
    <name>A0A8H7PS23_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein BFR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_003454</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AATF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PS23"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025160">
        <property type="entry name" value="AATF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039223">
        <property type="entry name" value="AATF/Bfr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012617">
        <property type="entry name" value="AATF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565">
        <property type="entry name" value="AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565:SF0">
        <property type="entry name" value="PROTEIN AATF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13339">
        <property type="entry name" value="AATF-Che1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08164">
        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AATF leucine zipper-containing" evidence="5">
        <location>
            <begin position="196"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Apoptosis-antagonizing transcription factor C-terminal" evidence="4">
        <location>
            <begin position="407"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2178201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="527" mass="60521" checksum="56D5CCD7EE340D40" modified="2022-01-19" version="1">MSAKSKKSLAEQLADLDTTAPADIDPEQFEDSLIERGAEEEDGASSDDDRNARDHYVNVGKSALRNSQFLMEDPKYGGKRSNRKNIFEDEQLEESSDDQDVEHDDDEDDEIDEDAGEMLNEDDESDEELDSDDMGEENGEDGSEYDDEEAGSDENESEEDEAAPLENEAEVQEELKRLREEEKKMISSLNKTAQSDIEKGQHVKQQLTLWDGFLDTRIRMQKAMTIANQLPQFDVWPEFLMDDECISHVESAKAKLRSLIDNVMDLRVDLIKDNIDSIIIPKDATNSRKRHLDDDDEYVEKLWDDMSQLNDLFTPYRNSTIEKWGNKVQIASGIPLNKKFKAFDQNIMTQVDTILGDGDRLIKRTQLKRTEYQPLGREIPSKEESKDGVDEHLADHDAEIFDDNDFYQQLLKELIESRMVDTDDPIALGMRWAALKQNKQKKKVVDTRASKGRRLRYHVHEKIQNFMVPIPTGTWHEEMIDELYASLLGRKQMDMTGDADIEEEKVAEEEDHEIVNGEAVDGLRIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTA9</accession>
    <name>A0A8H7PTA9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_003953</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTA9"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="274"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="97"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2180164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="336" mass="37676" checksum="FA2FE0CC6F31837A" modified="2022-01-19" version="1" fragment="single">LLYVVKIANLLNVESETPLPDNMRSSTLLEQIGHERSWTSQQMDSDIAILVHNRLYFVKDLRVLSAESWKTINLLPIVKDLLQKAINVGIESEYDRRKREKYERKASYDKHEKNEKNEKSEKKDKKDKKKKKDKQKDFDSLGDKVISSEKSEDVPYGVTSDDPTTLRNTLQNSSTSLTGANGVQGNGEDEELSPKSPSEKMVSFDSQPSIIDHTSKKEVFESDSSNSSDSDSMSESSSSDDNKPLTRVSDNSAVRTTMPLRKIKAVGSKIHVLTTSGQAYECERYCPHKGVDLVTWGQVVGNSLVCTKHNWNFALDKGGANNKGSKSLHACKINDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTD3</accession>
    <name>A0A8H7PTD3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotidyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000007">
        <property type="protein sequence ID" value="KAG2179164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTD3"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42883">
        <property type="entry name" value="GLUCOSE-1-PHOSPHATE THYMIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42883:SF2">
        <property type="entry name" value="THYMIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="288" mass="31904" checksum="5B4B0FF970A71052" modified="2022-01-19" version="1">MRWVIGQVLDLKLVLDMAVENVKVLIMGAGYGTRLQKDLLNDKTGKYSHLIGLPKALLPLGSQDALITHWVHLLAKNGIPSSSVHVITNDACHSSFIKWAKRNNVPENNIASDGTTSNETRLGAVPDILEGVKRFGLSGDNVLVIGGDTLFLHDFDLSQFLATFKQNEACLVTAYKVSDETVHKVGIMEINKDGRITGFVEKPQPTETDSRFACPCFYLFHQKSLSLLDQFLEECRSRQAGLEEFDATGKFLAYLYPRFAVQTFGISGRIDVGGLASYIEAAQYFQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTE3</accession>
    <name>A0A8H7PTE3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Aminopeptidase</fullName>
            <ecNumber evidence="16">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">INT43_003539</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14 16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="16"/>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTE3"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 16" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 14 16" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="20">
        <location>
            <begin position="81"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="18">
        <location>
            <begin position="333"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="19">
        <location>
            <begin position="621"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="15">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG2179756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="972" mass="109336" checksum="58726CA44FCF0591" modified="2022-01-19" version="1">MVGDCCLIIIILLLPPLGVFLMKGCGADFWINVILTILGYIPGHVHAFYVMVKQREIRQQQRASRKKMATTSRQVLPTNVKPVHYDLTLRPDLTNFTFDGRVMVDLNVNEESKTITLNAHEIKLSSAKLKSSALKTESSQEATDISYNEQKNTVTLTFAEAVPAKSKATLDILFEGTLNDQMAGFYRSSYKDAAGEIKYLATTQFEATDARRAFPCWDEPALKATFDVTLVVPSELTALSNMNVIAEKPFQETGKGPNVGKHEGSQTGKDVAGATDLKEVKYATTPVMSTYLLAFVVGPFEYIEAHTTGEHNGESVQVRVYALPGNKELGRHALNVCTKALEFFASVFGEPYPLPKMDMVAIPDFEAGAMENWGLVTYRTVALLFDEKSSSLAFKRQTAYTVCHELAHQWFGNLVTMEWWDHLWLNEGFATWVGWLAVDHVFPDWDVWTSFTNDDMPRAFNLDALRSSHPIEVAVNDPAEIHQIFDAISYYKGASVIRMLSSWLGVDVFLAGVRRYLHRHKFSNASTGDLWKALSEEAGVDVSQFMQLWTKNVGYPVVKVDVIDDKTIEVTQSRYLSTGDLKASEDTTNWWVPLGVLTPNKIESYTLTEKTQRFSVDASSFKLNAGQSSVYRVQYPIDVIKKFAEEVRKPNNGLLSNTGDRVGLLSDAGSLCVSGEQTTSAFLELAQAFQNETEYFVWSQISTHLSNILSVWYEQPADVKDGLKALRRSLFAPIAHKLGWEFKPTDDYLTNMLRVLVLSNAGRSGDKEVVEEARNRFWRFVKGDNEALHPNLRGPVYNIVLKNANDEAEETQAWEEILKIYQNEALTSDQRLTALAVLGDAKSEALINRYLAMSLDEKQVRGQDSIYVFRTLGSNPDTRNLLWEFFSSNYDLLHTKFSKSLSLFGIAVKSSVDGFADERRIEEIEAFFANKDTKEYARPLQQAIEASKVNAEWLKRDSQAVQDWVRGYVARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTI1</accession>
    <name>A0A8H7PTI1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTI1"/>
    <dbReference type="OrthoDB" id="2335477at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="183" mass="20534" checksum="4ED590CAAF57FA57" modified="2022-01-19" version="1">MDLTNKYTTGYAAMFTYAMWYAMKETNTMLLEESSSYYDADFHGFDPTNPPFEAWGTNVRTFYPILTFVKIVQAISFVFASLTLMAHLKINYKVLQAVIVGKFALDIWCIWELCQAVTSWPVVKQPTLDLLSTVAQPRIWFTAGVGGAMVAVLVALEGVNVLKLAFETVMGKTDSDAQQKKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTI8</accession>
    <name>A0A8H7PTI8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_003859</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTI8"/>
    <dbReference type="OrthoDB" id="2431892at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="274"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2180072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="337" mass="37846" checksum="D4631BE18BB1ED40" modified="2022-01-19" version="1">MVHPAIVAAIIGAAVVAGVVTYYYIDDHYHNEYEYVQTTRYEHYSDSDSDDEEQGFNARRLLQKAGLRRRRRYRDNNTPNESFNMAARDEKSSMSSASDIDMKRQLLESERQDLRLDEEEARLRRERLRSRGNSILGIMPTTMEDQMAQAPNPTHDNPFADSHEVPKVEKSELFEADNSNLANKANSAPLSETSSHHNTLLDNDEDTPYGSILSSILGNSAHSPLMRPVSPRQDPATEAWRYDDHEFIEANEQDDAMEYESVETSLQLPRARGHSNATVSSSSSWSDIEPSSSQNKSDLSDSDLSIIGRERSSHDGRSASEDEDGFVNVGGDDHNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PTW1</accession>
    <name>A0A8H7PTW1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enhancer of mRNA-decapping protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_004016</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EDC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PTW1"/>
    <dbReference type="OrthoDB" id="10030313at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612:SF0">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DFDF" evidence="7">
        <location>
            <begin position="233"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF N-terminal" evidence="6">
        <location>
            <begin position="359"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2180227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="601" mass="65206" checksum="5BA69AFADB5DFBFA" modified="2022-01-19" version="1">MGYLDFKGWFKDVYSSSFRMAQSFLGLRVSLSLNTGLSIEGKVSHIDSNTQLLTLSDVLIFLPGQATQRAPLYGVNGSDIKDLQILPESTSLAPPTTTVTNTQQQNQAQQQPHQLQHSQAMTSAQRQTMQDPSSALQASPSRSMSHPPPPPSVRPKSIARTDGAGGDGLKQVVYDARAKKVDESSATESVTTTKPQKKKTRQIQTEAVPQQSKNSRRTKNGRKANVQPVHEWAGGDVNDFKEEEFDFQANLDMFDKAKVFAEIREMDETAPETRLVTINRLPQPGRGAGTTNNNGSSPNRVNLLPSENVLDEQIDPGALSDDSLTSEGVEYMRGKRRGSKPSQRSKIVVMSSGILCPVVTSQQITTVEQECGLDRDQLIENAGRVSSMMAIQTLGGNRRNSDHSTAPVPVVVILAGNNTIGAYGFSAGRHLVNQGCTVIACTGSMPPYQSMVATHQKMFEHAGGRTISSLTQLPNTPVDLIIDALMGAQYNYKNLMHEKKAQQLTSSLISWANANAAPILSLDFPSGNQTAQDCSSQGPHRIHPKWTVCLGAPKTGCTSRDITGELYMGDLGIPRVCWKRAGVKGGSMPWGAEFLVALEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PV25</accession>
    <name>A0A8H7PV25_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PV25"/>
    <dbReference type="OrthoDB" id="2280248at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="138" mass="16004" checksum="EF845854B09D1EFF" modified="2022-01-19" version="1">MIPRLPPFLLIALGGVTVYGIQNVLSRLEQRALEAPGSKPRIPFRIEHARALRIARAGIIGATLAYTGYWIYDRRHNRPTPASQAYGEQKAFHEDQYADRERTQRQYVDELRLKQRLSEEERRAQLRGEVEMMGRSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVQ4</accession>
    <name>A0A8H7PVQ4_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL27m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008779</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVQ4"/>
    <dbReference type="OrthoDB" id="1867012at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000042">
        <property type="entry name" value="50S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_bL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_bL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_bL27_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2181197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="167" mass="18671" checksum="09FD68FBF0F44F50" modified="2022-01-19" version="1">MSSILSQVQALRPKLATGATSSLFSHAQLPSRATMSADKMQIRWATKKSGGSTRNGRDSAGRRLGVKKFGGQEVIPGNIIVRQRGTTFHPGDNVGMGKDHTIFALQPGYVHFYKDPTQPKRRFVGVVFDRAQTLPTPFNQPKPRRFDLIDLVAWEEQRNLKLKDLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PVT8</accession>
    <name>A0A8H7PVT8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor spt8 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_008840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PVT8"/>
    <dbReference type="OrthoDB" id="10260946at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057544">
        <property type="entry name" value="Beta-prop_SPT8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23798">
        <property type="entry name" value="Beta-prop_SPT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="68"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="209"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="269"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2181257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="501" mass="55632" checksum="2C00960EC7BDA1DC" modified="2022-01-19" version="1">MSSDEEDVDLNEDTTVQLDNVSDDGTDMMDTEDLIPTSEEQQPSTIDDTIQKRVLPRMKPHADDCKTYNIIPQGAAIHPNPIYSVAATRCFRWFVTGSEDGYIRKWDFFASMNGKSTLTQAQRHQLVDSITKAGYLASWWENEEQPEEVKVKAESSESIEVTPVPESKLSPVYSLDIHSEGLWALSGLENGSINLVTVRHEEGKCHHVFRKHTAPVSVLTIMPEERSFISGSWDKSIVEWDLETGSIVREYGGYSSQISSASFRPLHKEVASADSNGEADKKEEAEDIKNEDDEDMHTSEEKDEQVEEIGPDPMFKDPNIMLTTSIDGNCLIWDRREPTEAARRLSLPDKTPPWTLSACWGADGSKIYTGRRNGTVDEYDFAAQKLIRSFRMPANSGPVSCVASLPNGSHIVCASNDNIRMWNTSIDSTFTIQPGDDGGFVKPTKLSSVIPFTILPGHHGAVISSLLIDPTSRYMISTSGTRGWEGTSNNGCLIYEIQPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PW24</accession>
    <name>A0A8H7PW24_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Swiss Army Knife 2H phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_008990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PW24"/>
    <dbReference type="OrthoDB" id="19045at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054498">
        <property type="entry name" value="2H-SAK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22547">
        <property type="entry name" value="2H-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Swiss Army Knife 2H phosphoesterase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2181407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="253" mass="28332" checksum="AA9B0B6A126647BA" modified="2022-01-19" version="1">MSDSVSERALNQRRMRDGYPYHITIANAKQTTSEMRSSRSLEIMNKIAAAGSPPVNLGLGMVRHAKNESRSWYCAISWPAGQQIRRYFNLLPRDLHLTLGFDHKDIHIHKGPSTLLIHNTASSPLTKQQIEGLTYAALVESYTSKEASLRSLSLALAHAEYIRDEIMISSIANSMTRVQTGTRLEEVETPFEDGNTTQLAHNMTAVEHLTVQLESMTTSQQIYTDTGSSQEKPRTTIMTDALTKLTLVEVDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PX41</accession>
    <name>A0A8H7PX41_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">INT43_007161</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PX41"/>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097037">
        <property type="term" value="P:heme export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF4">
        <property type="entry name" value="GH15861P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG2182234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="50488" checksum="BA0C3FBA45838A03" modified="2022-01-19" version="1">MQETSERSPLLQGRMMPGPTRWFVLASFCLFSFTNALQWIAFSPALQTFAKYFFDETSLKTTNAINAFSGSYMIIYPILVPFSFSFLEDKEGSSIGSGLIRGVRIGAILNALGGTLRWLGAYPSWQGYLVVFAGQILSAVAQVFMLALPPRLAVAWFRPDEINFVTAIAVSFNNLGIATGFALTPILVPGTKTMMTDIPRFMALQMVLCLVALAAICYFFKKDPSQNYHRVDEPEIEIDAAPSSGFSKEESLTLFRQPSFVLLLLSFAMVMGAQCAVFSLLAQILSPSFELENNVAVGLLGSVMLLIGVPPSILIGKLLDATHRYMLICRLLYISVFASVIALTVSAGLEWFTLAVAACLIFGIASSAILPAVFQWAGELYYPVNEVVPTGYLCMTGNIGGWLLVLIMGWTENPDVRFTMLPPMLILIASLFVGIVALFLTGGELKRLASQKYPNVDTSIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PX69</accession>
    <name>A0A8H7PX69_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Phosphoacetylglucosamine mutase</fullName>
            <shortName evidence="12">PAGM</shortName>
            <ecNumber evidence="4 12">5.4.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Acetylglucosamine phosphomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10 12">N-acetylglucosamine-phosphate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">INT43_008390</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23804"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="5.4.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12 15">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.3" evidence="4 12"/>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2180811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PX69"/>
    <dbReference type="OrthoDB" id="1928at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03086">
        <property type="entry name" value="PGM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000003">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000023">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000038">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049023">
        <property type="entry name" value="AMG1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049022">
        <property type="entry name" value="AMG1_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016657">
        <property type="entry name" value="PAGM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21405">
        <property type="entry name" value="AMG1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21404">
        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016408">
        <property type="entry name" value="PAGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 12 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="17">
        <location>
            <begin position="56"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="17">
        <location>
            <begin position="107"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="19">
        <location>
            <begin position="198"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="18">
        <location>
            <begin position="305"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="16">
        <location>
            <begin position="460"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="13">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="15">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="379"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="504"/>
            <end position="508"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="513"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR016408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF21405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG2180811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="548" mass="59423" checksum="0EDB4FC3DD7DD919" modified="2022-01-19" version="1">MTQMTLDQQKIRAASDLHPTPEVNFVYGTAGFRMRADMLDSVLFKVGILAALRSYKLNGATIGVMITASHNPEEDNGAKLVDPRGEMLEQAWEVYATELANARDADSILKAVDSIVAQTGITFDKGANVIYGYDTRPSCASLVKALEDGLNAAGAKPTNFGLKSTPQLHYLVRCINTAGTNDAYGEPTEEGYYIKLSEAFKTLMKGKPTLSPITVDCANGVGAPKLADFLKYIDHDVWAANIVNDDINTKGKLNYNAGADYVKTQQKAPLGATLAPGERYCSFDGDADRLVYYYADEAGVFHLLDGDKIAGLAAMFIMDLVKSAGVDSINVGVVQTAYANGSSTQYLTKQCQVPVSCVNTGVKHLHHEAEKYDVGVYFEANGHGTVLFSPEALNTIKTTESKTPAQNTALKQLRALTELINQTVGDALSDMLMVEVILAHRNWTCQEWDQAYTDLPNRLVKVVVANRYIFKTTNAERTVVEPEGLQAELDAIVSKYNNGRSFVRASGTEDAVRVYAEAATRTETDYLAIAVAQLVYDRGGGIGSLPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PX87</accession>
    <name>A0A8H7PX87_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_008711</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PX87"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="105"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="12">
        <location>
            <begin position="1003"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="448"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="625"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="814"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="952"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="575"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="652"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="828"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="952"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="981"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2181129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1091" mass="120927" checksum="3EC2600402CD3A63" modified="2022-01-19" version="1">MAATVFPMAQNRPSQQSSSEAPPNTIPVQPAMHTSYTARSRPVSTPVPLPFHEYMNEIEHSNYMRAYQHNAHYSPSPYATRHSSQDYRQRQSYYQYRKQNMFGPYLMLQTLGEGEFGKVKLGMHVETEQEVAIKLIRKESVDNSTRLSKVEREISVLRIVRHPYIVKLYDVLETEKYIGIILECASGTILAPERGELFEYILARRYLKEHDACRLFAQLISGVHYLHQKHIVHRDLKLENLLLDRNRNVIITDFGFANQFSSAKDDLMATSCGSPCYAAPELVVSEGLYVGSAVDIWSCGVILYAMLCGYLPFDDDPANPDGDNINLLYKHILSSSLAFPDYVSEKAQDLLVKMLVPDPIKRCDIQTIMNHPWLKEYRPLFAKSVRELEFEATTSAELTLSPVGAEAYRYAQQSLGLQEYASNRQTGLSDYDADGDHSDQVTDELSIQEHQSSNEDERMEDAVVPTKQSVHEQANSELPKRKSESRSANATTPQHNQVVPIKNDPKLTDSPKHSRTQSANIKLNEKHIPQSPTPSASTTEKRGHRKGYSTEKFFSLLSGGGNSTTKSSTLGPLRRNNTMNLSPIPSSTKQSGNDNASQTRGHGRFNSTSAARGTGSILHAKFLSSISNSPSRRSVHHDASVDRPGEGPTPGASISTSFIPSNTSQQSPIPGSTRTVPQSMPAVSQSTNIRGAVRGTRRKAMSLLVTPVSEETEKDDPYRWLAGIGSETGKKAMAFGRRVSVRGRTKSEKPYADSDKDSGTMEGIVEEAATKTMQEKDFPPTNPRATGKKMMEWIKRKSNLSDLRSPISMSSSTFDNLGRPFSHSATKSQPSQHGSNSSSWVPEAAKLRIYHGAVDQSALTSRSPSAVFNEVKQALQAMGIETKRDSDYKIRCIRKKRKTKAAHPISTGLSLSNDSADTLEVDSGMSLSTAEQKKRRVGGSIVIRNLLRRSGSHYQSTNNNSISEQTTITKDSDEQPSIKHSTGSSVNSTSSSKVTNPMYGDPSMDSGDEIRFSVELCKMKNLPGLYIVDIRRMRGNVWGYKWVYHQLLETLDLYGKGGYISAPQTTIVDEPSSPTKTELDAGLRSIAGIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PX94</accession>
    <name>A0A8H7PX94_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PX94"/>
    <dbReference type="OrthoDB" id="2306919at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2181967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="153" mass="17929" checksum="2DC74E45B54D87EF" modified="2022-01-19" version="1">MGLSRLPTPEPILEKLLSRDPLPPMVPSHVYNAELTAKIDALPLHANVKAGLHLLNDDWKKAHDLVEPLDPDQTANYWHAIVHRREGDFWNSKWWFRKIRHPLLKTVYGSDENRGAQAFVDQVERGENLMRLEEKQFNEMRLLMEHAFKEYAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PXT9</accession>
    <name>A0A8H7PXT9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FANCL UBC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_008693</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PXT9"/>
    <dbReference type="OrthoDB" id="10263265at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043240">
        <property type="term" value="C:Fanconi anaemia nuclear complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23832">
        <property type="entry name" value="DRWD-C_FANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.20">
        <property type="entry name" value="RWD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026848">
        <property type="entry name" value="Fancl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026850">
        <property type="entry name" value="FANCL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043898">
        <property type="entry name" value="FANCL_d2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044037">
        <property type="entry name" value="FANCL_d3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043003">
        <property type="entry name" value="FANCL_d3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13206:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE FANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13206">
        <property type="entry name" value="UBIQUITIN LIGASE PROTEIN PHF9 FANCONI ANEMIA GROUP L PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11793">
        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18890">
        <property type="entry name" value="FANCL_d2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18891">
        <property type="entry name" value="FANCL_d3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01197">
        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FANCL UBC-like" evidence="2">
        <location>
            <begin position="144"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="FANCL UBC-like" evidence="3">
        <location>
            <begin position="233"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="FANCL C-terminal" evidence="1">
        <location>
            <begin position="341"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2181111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="44976" checksum="184D5CB8B7D7C75F" modified="2022-01-19" version="1">MDLPGERVQFHKLAESFERSTFRAPAVILRGLYEAAAMFILSERIDLFDVNKVTVNKNEEHYIVIRKKVPTTLAGASLFGSPNLQRLIGKQQDTVAQLLARHSEPRQFLSDLINHLERLSVHENANARDNDLVKLECRKLPVHQYNLLLKQFEDIGLQNLKLSKDLTRFKIYIQDVSGRQHTMDCQIPTQGNSIYPLKIDIDLPCQLPALITKTDIPTAVANVKEVINDHRILFDEMDNLDKHAFILDPASPRREHTHRRLALGHHCSLHIDITNLKNPRSEPPVMQLYGAESRIASWRDALNRNLSSWNTSKSILENIVNTLEISQLPQKDGIGDNAVANVECGICYAYNLNALDQNSKQTTLSSNPVPDQICNNSSCGRAFHHQCLYEVSLVLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PY01</accession>
    <name>A0A8H7PY01_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acyl-CoA dehydrogenase NM domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_007258</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PY01"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF13">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="10">
        <location>
            <begin position="17"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="9">
        <location>
            <begin position="143"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="8">
        <location>
            <begin position="257"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2182328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="48600" checksum="63CF9D6FF1858D4F" modified="2022-01-19" version="1">MACNTLVDITKLSPKFQELYAKAKDFVENDCIPAEPVWHEQMGLGDQRWKVIPPVLEGLKKKARSLGLWNLFLGRDYQEGAGLTNLEYALIAELTGRCPHIAPEAMNCSAPDTGNMEVFAKYGSPAQKKKWLEPLLQGKIRSAFAMTEKRVASSDATNIETHIQKVGNEYVINGLKWWISGAGDPRCAVYLVMGKTDPNNKNPHRQQSIVIVPADTPGITVVRPMQVFGYDDAPEGHCEIIFKDVRVPAENMVLGEGRGFEIIQGRLGPGRIHHCMRSIGMAERGLDYMLARVTDPSRRTFGKYLYEHGTIVSDIAQSRMEIDQARFMVLNAAKRIDEVKAKGAMKEIGMAKAIVPKMLGTVLDRAIQAHGAGGLSQDFPLAKWYAGSRTLRFADGPDEVHIAQIGKVELRRANDVKATFEKRDKTSQELLKKQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PY66</accession>
    <name>A0A8H7PY66_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphotyrosine protein phosphatase I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PY66"/>
    <dbReference type="OrthoDB" id="2011805at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43428">
        <property type="entry name" value="ARSENATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43428:SF1">
        <property type="entry name" value="ARSENATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0059">Arsenical resistance</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="2">
        <location>
            <begin position="7"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2181978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="164" mass="18087" checksum="5F2AE775D154BF2E" modified="2022-01-19" version="1">MSSGRKDSVLFVCRHNSCRSQMAEGFARALFGPTSPSPFFGHIDSAALEGLSKINPDAIVTMAKLNIDIKNQYSKMIESLSPNDFSIIISMCGCGATVPVAWKEGKRFEDWNVNDPTGGTEAGFEVARNEIQNRVKELVSSIQEDRAPTYSLYYDDVCPLPSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PY93</accession>
    <name>A0A8H7PY93_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_007523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PY93"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2182592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="101" mass="11080" checksum="C07D9CB5E522565D" modified="2022-01-19" version="1">MTTFSQPGQSQILCRDTSVPNGNARYCTTRGDLTEQTNRNPQRGKVLDDNALPDDHCQYEVKSNNTYACYLPFLAEQPVSASGSAADDAAFEIPQLGSRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZA5</accession>
    <name>A0A8H7PZA5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="5 7">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_007449</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="5 7"/>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZA5"/>
    <dbReference type="OrthoDB" id="2015992at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10420:FF:000007">
        <property type="entry name" value="5-formyltetrahydrofolate cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407">
        <property type="entry name" value="ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="8"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="142"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2182518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="211" mass="24142" checksum="654E28B7DBEEA977" modified="2022-01-19" version="1">MSSVRVLKKALRKELAGKLRVLSKETASQDSKLVTEKLLSLREYRNSQSVSVYISMDGEIDTREIIRNIFETNKACYVPRFTGSTTMTMVKLTSWDDYLNLPMNKWNIPEPHADEVREDALDKQGLDLIIVPGVGFDVERNRIGHGRGYYDRYITKCAEWAALNNRLPPKTVALALQDQMVEIGRIPLEPTDRKPDVLLTPCEELRDAHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZB2</accession>
    <name>A0A8H7PZB2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_006500</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZB2"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000751">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF71">
        <property type="entry name" value="CITRON RHO-INTERACTING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="93"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="358"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2183494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="499" mass="56990" checksum="1890E9416D578176" modified="2022-01-19" version="1">MSDDASFGPKPRSSTSLLWSERIQKIQTILSQQDLVAITDNEILLDTLIATWDDHRSTIKSIASPRKETSLCVKRHLDMIDNLKDLSLQMDDFEMIKPLAKGQFGTVYIVKSRLDDQVYAMKIQPKDGLLRQRETAFFMEEKNVLVQGNEWMPKLYASFQDNENLYLVMEYAGGGDLFSVLDRTETLTFNEDEARFYIAEMILAIESLHKLGYVHRDIKPQNILIDAHGHVKLADFGSCINLDEHGKVTSTTPVGTCDYISPEVLQAHEGNVKYGTEVDWWSVGIVLYEMLQELPPFYSDSVNETYRKIIFHEESLEFSDEYSISDDAKDLISRFLCNKEERLGCNGIDEIKSHLFFAGIDWDRIRESTPPFQPVLASPDDTSNFSVHDEEEDMSIPTVPGFARPATGQTRKESEGKNTPFIGYTCLKNVGIPLNEQTSINGNDDSICSFNREEEILRLKRQLDNTSRNNRTPILKFENPMDQPVLHSSQWITKNKLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZI5</accession>
    <name>A0A8H7PZI5_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_007481</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the APH-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZI5"/>
    <dbReference type="OrthoDB" id="6507463at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009294">
        <property type="entry name" value="Aph-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12889">
        <property type="entry name" value="GAMMA-SECRETASE SUBUNIT APH-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06105">
        <property type="entry name" value="Aph-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2182550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="272" mass="30611" checksum="D65B2AC3316A0493" modified="2022-01-19" version="1">MSLYTFFGCLFTAYGPLLSIFFLYIARDAQLVLLMVCRYAEIQDLLYNRIAVFNVDIFFLRSAFFWLIAMLLSSVIWFAAKPIQNMNTVTILYSVIIQELFRWGLFKLINRAERGLMIVSKNPKSLFNRSVFAFVSGYGFGLTSALISYISTLVQSIGPGVMMCPSCPQATLFFISAITTSLASLQHILWMMLAFEAYHTLPSTIGIIQGIWVIISHLGVSYATLMNSMESLYLGCVYAMIVQLVVLAISTSLVISNLKKHYGEAMFSRNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PZZ7</accession>
    <name>A0A8H7PZZ7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_006384</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PZZ7"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000055">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2183378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="308" mass="35067" checksum="CAAC708835858A01" modified="2022-01-19" version="1">MVITQDGLLINTEAVYSEVTQEVLDKYAPGQKFTWDFKSKLMGRIGHESAAMIVEHFNLPMTPEEYIEISAKIQEEKFPLCKPLPGVERLIKHLHNHKIPIAVATSSLRSKFELKTTSCRDLFKLFDYVVCGDDPEIKKGKPSPDIFLTAQKHLGNPPSENCLVFEDAINGIEAGLAANMHVVWIPDLNLLQLNGRENTHGACRVLESMAHFDPEVKILNYYSLTGRPEPYRYYISNVHRISLCLPSKAMITLSPLKSSLTEILHKLSILMYDMYFNEQGSQYIEKFSCRFEFYLSIKKTLSTVTMIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0E6</accession>
    <name>A0A8H7Q0E6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_007361</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0E6"/>
    <dbReference type="OrthoDB" id="258627at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="entry name" value="CobW-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF62">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="6">
        <location>
            <begin position="13"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="CobW C-terminal" evidence="7">
        <location>
            <begin position="270"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2182431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="360" mass="39984" checksum="81190DE7F27EA470" modified="2022-01-19" version="1">MHFSSESMNRIGVTILTGFLGAGKTTLLNNILKQLSEMADKPSSLPKRISIIENEFAAAIGFENEVLTRRYARLENLYEFGFGCVCCSSSGELLEVLGGIADRNKEAKNEDETTDHIILESTGLADPAPILNLISQSSGSGIEEEFYVDSIVTVVDSKTFLSRMTDESQDKENSTFKNEPLAQILTSDTIILNKVDLLDDLTREKDIKQLEDFIETYNPSAKILKATYGDVDAESIFYLNDTQRLSQKVFNSETDKKHDPSIEHTLVLVNGNVDTDKVEKLVKNFTNKMGNKLLRVKGILSSPDSDYKMVLQGVSNQLTLTANHKWDAAETRNSRLAFIGKGVKAENQTLQQELEAARIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q0M8</accession>
    <name>A0A8H7Q0M8_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_006360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q0M8"/>
    <dbReference type="OrthoDB" id="2337427at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2183355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="117" mass="13540" checksum="B56FF777D4E3D05C" modified="2022-01-19" version="1">MKFDPLTNQTNMTDELCLVKWWIAISASALTSFINFVLDMLFIYLLNCMSKEMTQKFLFPYDDPEKPMHFRTQRMRDTMAKSEIRPPKPSYTLGDGQISQCSMADILTPTNQVDKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q280</accession>
    <name>A0A8H7Q280_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_000997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2185084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q280"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2185084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="173" mass="18925" checksum="B90905C8937D09A1" modified="2022-01-19" version="1">MMAQVINAHVTTHPIHADFKTPVHLAQLLKMVKLLACLVHAVFCVTMIMLAVIMRVSMNRPTSAIVEPVETYAQLPQMGKIFACLECVVSHVTVAILAAMVHAPMNRPTSVIVELVETRVQSQAMAKLLAHLEHVAFHVTAAIVVATLQALMNRQTSIIVESAETFVQSLEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q2R8</accession>
    <name>A0A8H7Q2R8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">INT43_000790</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q2R8"/>
    <dbReference type="OrthoDB" id="957735at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000105">
        <property type="entry name" value="WD repeat and FYVE domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017073">
        <property type="entry name" value="HGS/VPS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46275">
        <property type="entry name" value="HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46275:SF1">
        <property type="entry name" value="HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VHS" evidence="11">
        <location>
            <begin position="28"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="10">
        <location>
            <begin position="175"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG2184877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="490" mass="55035" checksum="8F4115D53086109E" modified="2022-01-19" version="1">MSSFWGTSEFDELITNATSELRPSGDIDLAKTIDIADYIKSKKVSPKDAAKALRRRLTHTNPNVVLLALHLCEFCVQNAGKPFVNEVATIDFINVIKNISNDKASDNATRAKAKELIQVWGLAARNDAKLSNFTDTYQEMKSSGVEFAAEPQNLNALYFESVGVDSQICSQAPEWTESSVCERCRTPFSLTNRKHHCRRCGGTFCQLCSSKRIRLPQLGINEPVRICDSCYTEVKLKRSSKDTPKANNSSNQHTPTDSGAEELDEDLKRALQLSMEESNQLLTARAAEKTDAEEMQQRSPGLDRIPRSQDSADTNDHQDILEQVEQLCRVMNSNLDAGVHEPETPQFRYDLDQMQRCLAERLQYASNKQQSAMVLHDRIQWALQTYDHLLESRIHSLHSNGHSAELYNPTNPQRSIDDELFANATAPDFSMADQAIIEDEARVSNDQNHMQYNAPPVVQHQYSGPYVTQSNVNAPVPTKSQDMPLIDLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q327</accession>
    <name>A0A8H7Q327_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bifunctional chorismate mutase/prephenate dehydratase</fullName>
            <ecNumber evidence="6">4.2.1.51</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Chorismate mutase-prephenate dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">p-protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">INT43_000319</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>prephenate + H(+) = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="6"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q327"/>
    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04905">
        <property type="entry name" value="ACT_CM-PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13630">
        <property type="entry name" value="PBP2_PDT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000034">
        <property type="entry name" value="Chorismate mutase/prephenate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="entry name" value="Chorismate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008865">
        <property type="entry name" value="PRK11898.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022">
        <property type="entry name" value="PREPHENATE DEHYDRATASE P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022:SF19">
        <property type="entry name" value="PREPHENATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="Chorismate mutase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00857">
        <property type="entry name" value="PREPHENATE_DEHYDR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="18">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Prephenate dehydratase" evidence="19">
        <location>
            <begin position="100"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="20">
        <location>
            <begin position="287"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG2184410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="369" mass="40771" checksum="63234E1C36DC87C3" modified="2022-01-19" version="1">MGDLPSLRQKIDSLDTIIVNLLNERAQVSLDIGATKKSLAAESSDGRSEEKQPHVYMPSREKEIYDKLSTHNRGPLNNDSLNAIFREIISASISLQQDVSVAYLGPPGTFSHQAAYDKLGDSVAYVPQKQISAVFDAVEKGRTTYGLVPYENSTFGSVVETLDRLMLTETKIRAETYLTVHQCLLSNSKLSDIKKIYSHPQGLGQVQSYLSANCPNAERITVKSTAEAAQLAALETGAAAICSSICASLYGLEIVAQDIEDVKTNTTRFLLIGTASDRPTKNDRSLIRFTVDHRQPGALCDGLKVFKDQNLNLSKIDSRPSRQRPWHYVFFVECSGHAEDENVQQAVKDMEKYCLDVCVLGSYADQRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3S1</accession>
    <name>A0A8H7Q3S1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="15">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">INT43_000681</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="15"/>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 15" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="538"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1003"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1030"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1073"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1109"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1147"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1180"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="101"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="147"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="370"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1299"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG2184768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1339" mass="145825" checksum="B483D3B9764A5573" modified="2022-01-19" version="1">MTASTPKPQPPTIITDPSALNDRSEDTPALTLYSANDAPSESAPQSPLYAPSTHEDNHRSTNNLSIHNYLQPHDDAGNPFAFTTDQLGALYDPKNIELLAAYGGLEGVAKGLHSNIKTGLSSDEQAPFEPVTLSDITDTQIDYKVASDTKDTADHKEATESEETKKHPPKKTNSVLSHTATNSRYAQRISSFGANVLPEAKGKNIFQLMWMAFKDKTLILLTVAAIVSLAVGLYEDLGTEPELDANGNPEPDVHWVEGVAIIVAIVIVVMAGSVNDFQKEKQFRKLNAKKEDRDVKVSRSGQQGMISIRDLQVGDVLHVEPGEIIPADGIFIEGHNLKCDESTATGETDAVKKQGWRECYRLHEIYQRQHPDDGRSVSAASGVSKPDSPSTLVPNNNQTQNNQLHVQGSFLAPPSPVSMDVSSSSASTTSSEPAFEAGAHLPDPFMISGSKVLEGVASYMVTNVGESSFNGKTMMALRTEAQSTPLQEKLDSLAEMIAKLGSAAGLLMLLVLLIRYFVGWKFNGIPTKPADIVTQIMNIIIVAVTIVVVAVPEGLPLAVTLALAYATQRMLKDNNLVRVLAACETMGNATTICSDKTGTLTQNVMTVVAGTLGSSFRFQKESPASRKDLVDITKVRETAPESVRLLINQAVAVNSTAFESTGDDGQVTILGNKTETALLGFSQSLGDNTLSYLRSRWAVEQVFPFSSERKAMATVLRIPQLDASGKETKVIYRVHVKGASETLLGRCNKIVSMHDPSYRFHTEKADEDNFQVKVRTMDEATQGRMNKIIQSYASRSLRTIGLCYRDFDHWPPHKTKKHFKEEEVEVPYEDLVGDNGMTFIGVVGIEDPLRPGVKDAVIACQKAGVFVRMVTGDNVTTAKSIAKQCGIFTSGGIVMEGPVFRNLSAPEMDEIIPRLQVLARSSPDDKRILVGRLKELGETVAVTGDGTNDAPALKLADVGFSMGITGTEVAKEASSIILMDDNFSSIVKAVSWGRCVNDAVKKFLQFQITVNITAVLLAFISSVASSSQKSVLTAVQLLWVNLIMDTFAALALATDPPTPELLLRNPEPRSSPLISFPMWKMIIGQSIFQVVVTLVLLYSDILDFDTDSLFLQTVVFNTFVFCQIFNEINCRRIDNRFNVLSGLHRNFFFIAIFLICVIGQVIIVQWGGQAFQTTPLDGTHWAISIVVGLLALPIGAVIRMIPDDIFSIFFHNENTRMRYLEPDKLVSSGNTPSVYVAGGERFAWNTAYTNVTRELQNFREPKGENHLHRRRSSNALAAAIIPSFIATAPGAGWVASNEEENAHGEHAAAQDTSNSGIGLERCDSITESSVPADQSTPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q3X1</accession>
    <name>A0A8H7Q3X1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_000503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000002">
        <property type="protein sequence ID" value="KAG2184594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q3X1"/>
    <dbReference type="OrthoDB" id="2131431at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2184594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="45998" checksum="61EE1313B215F041" modified="2022-01-19" version="1">MSVLSQNSTFLRFCDDSTCHIDWRLTLMGGVESHALTIVNIIDLAWSSVLLVCGISLLFYRIFFKGHRIWERQDNGRLRPKPIESMLTLLMMFNLLRIIDSIVLLQDVSANIIVRSFLFEFAWQFGFAAFAVYLIGIATTLAQSHQAISTGWLPSSRQVDFLAVFLIIAPFVTNNICSILAGVYAQQGNYYVADIMTRMLYAFCTLVNIMGMHLRKFSTSSQSSSRMAAIRNGRSKIVIIMLAIVFCLASFALMLLMYGIFRAEIMNHVPASILIGTIWNFLGPIAITFVEIAIATNPRLPSLGFKSYNTKGSVSDNKSYPQDSVRGWNSGISHSTTDQQNIQSMYSTTADQPPQIPNPANSEHPKTHPGLALNIIQYHKDNFVRNEEYMIGDIPRRADSSEKSYTGLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q5Z7</accession>
    <name>A0A8H7Q5Z7_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_002378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q5Z7"/>
    <dbReference type="OrthoDB" id="2435580at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034954635" evidence="3">
        <location>
            <begin position="20"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG2185940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="143" mass="15448" checksum="426E7BB4161BD8EC" modified="2022-01-19" version="1">MLLRWLLVISSVLVLLAAAAPSASVSSDVHESSLSMSSASTPASLVPSLATSTPPLAPPVPTNTVNSGGFSDDARGEHDQQNWLQQHSRWVFVLVIGLLVAAAIIYYVVRGIRRARRTLKSENEKLASLSMHPPKYEEAAPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6B2</accession>
    <name>A0A8H7Q6B2_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002558</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6B2"/>
    <dbReference type="OrthoDB" id="2258292at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="389"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2186120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="480" mass="53792" checksum="FF7CED35B3DABC79" modified="2022-01-19" version="1">MDSAELGSSEPPIYNAALGDYEQHYLSLLKSIASLQWVRESLPSHTRYYESLKNKIKNEELTRQLLEGEIQLSRKSHDSTRFKELLSSMKTGSQSDICSYSDLIERLQKCHSRISNLNEQLEQAKDMHEDMLKNMEKLNGCCSELRILFDQIIPEPLTDPAYVIEEHTKNEVLSLESYIPQIESRLERCKEAQLKLYNARDAMENAMKSLPGAASILERQAMINNGTGRGGVRLGSLNVLLDMSVSSTKESEVFVEKSIRFVKDAVDLYPDMPMIPDTPISQKDETISVVLTSYRGYRLKIESLLRNFINPRVKLMQGDVTYARHSHESKRMEWVEQQLLLLEAVLRSQSRLQGVDIEPDLAAIRMGSHAAAGTASELGGRVAVDDALEVGESSTSPARNGPLPEYPKEQEQDANTGANSVTAGPSRTTVIETVNELPEYSRNISRTDQWSGRSLPSMEATQNAEADESSPFDQPPAYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6N6</accession>
    <name>A0A8H7Q6N6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_002738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6N6"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15465">
        <property type="entry name" value="bS6_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_bS6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="Ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2186300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12938" checksum="4584A06055E33770" modified="2022-01-19" version="1">MPFYELVCIARSNLAKTNMHDLLKTSASQVLDKGGVVRGFENWGSRNLPHRIKRHQQYFDSGHYWLMHFDANPGTVQDLGKKLRVDPRVLRHTVVKLGSKLEHITARPEKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7Q6W7</accession>
    <name>A0A8H7Q6W7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">transketolase</fullName>
            <ecNumber evidence="4">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">INT43_002796</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7Q6W7"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF2">
        <property type="entry name" value="TRANSKETOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="15">
        <location>
            <begin position="354"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="115"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="525"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG2186358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="678" mass="74385" checksum="DD426FD32A2EDB8B" modified="2022-01-19" version="1">MSKNDSLCINTIRALAADITREANAGHPGAPMGCAPIAHVLWRDFIRCNPKSSHYPNRDRFVLSNGHACALQYIVLHLLGYDLSMEDLKQFRRLKSKTPGHPERGHTDGIEVTTGPLGQGITNAVGLAIAEANLAATFNKPGYDIFDNYTYVLMGDGCMQEGVASEACSLAGHLQLGKLIVLYDDNKITIDGDTAFSFTEDVIKRFEAYGWHTQTVGDGDKDLDSIKTAIEKAQKVTDKPSLIKVRTTIGFGSKNQGKESVHGSPLDAEDIANVKKKFGLDPEKKFQVADEVYDAYHKFGERGAKLEKDWNELFAKYQKEFKAEGAELKRRLDGKLPKDWAKDLPKYTPKDKAVATRKCSEATLTKLVEALPELIGGSADLTPSNNTRWKGAVDFQPNSTGIGEYQGRYIRYGVREHAMFGIMNGIAAYQGLIPYGGTFLNFLTYGWGSARLSALSHLRTLFIMTHDSIGLGEDGPTHQPIETLALTRATPNMLTFRPADGNETTGSYIMAIENNDRPSVMAFSRQNLPQLEGSSIEKVAKGGYVLECPGKPDVIIVSTGSEVCIAVDAAKKLKEDGVNARIVSMPCTELFDDQPLSYKTEVFPTGIPIVSLEALTTFGWQRYSHAQVGMTTFGASAMYTDAYEAFNITADHTAKVSKDIIAKYKKIGHVPELSFCQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U6Q0</accession>
    <name>A0A8H7U6Q0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_008287</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ZNF598/HEL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="JAEPQZ010000020">
        <property type="protein sequence ID" value="KAG2171561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U6Q0"/>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16615">
        <property type="entry name" value="RING-HC_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041888">
        <property type="entry name" value="RING-HC_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056437">
        <property type="entry name" value="Znf-C2H2_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25447">
        <property type="entry name" value="RING_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23230">
        <property type="entry name" value="zf-C2H2_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="288"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="498"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="500"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="571"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="584"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2171561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="670" mass="75902" checksum="02F61CE78629B53C" modified="2022-01-19" version="1" fragment="single">MTSKKQQSTPAEEEEEEEELCFICTEPVATFAVAECNHRTCHICSLRLRALYKTRNCAYCKTEQKSVIFTKDPKKLFQEYTQDDTPLVDKHLNIRFEDQQTFQDSMILLQFNCPEPTCEVNCPGGWSELKRHVKKEHERLLCDLCTRYKKIFVHEQTLFQPSDLKKHYRFGDKAINKEDDSGFKGHPECAFCRSAFYGDDELFEHCRDKHEQCHICVRRGKRHEYYANYDQLAEHFNRDHYMCQWRDCLDKKFIVFESDIDLKAHEVEVHGSSGGRVQRARQMEARKVDVTFEYSGGRQSRNDRNKRDNQRETSQKDSADKSRSQEEFPQIGAESSRMQQLNIGSTQPNEDTRNKSKSKSTKGMKKPAGFGSLSQGNDWPELGQKATPPAIGTTNKPQVDAPVETVQKHTALLDKLAEYVNGDQARVERFRQLTSSYRKSNIDGKSYIDQVFKLLNSNMDQASRIIRGVEELLDDTSKKAEIVRYWRDKRTSLESFPSLAPSTAAQKTSVSNPSQRVLVIKSGNTRRGGTKTKTSKTNVWDKVAHAAAATPKASHITPPSSRPESPARSANMSRTPWSTGGAQTTSRPSASSSSGPTVRRVENDFPSLPPAPPKNQLIVEMRRSNSAGDPATRGWGKEPDSGEEATGEDEPKPVGKKGKKKGKQVLFRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U713</accession>
    <name>A0A8H7U713_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_000078</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U713"/>
    <dbReference type="OrthoDB" id="362021at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017126">
        <property type="entry name" value="Condensin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="280"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="722"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2172731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="821" mass="92312" checksum="5E0EB57690154AF1" modified="2022-01-19" version="1">MSSSFSPRVASPNLTRRNTASGQGDHSPVTLGSPSLDRHSGRFYRAGGPEESDRQSRRISARESLLRRVSGRSSLTGGDHAAIEERKLARPLDILTNAPKLPTLTNEQMYSNFEEWMKMCTDNKINATNSWNFALIDYFHEMTFLKDGDSINFQKASCTLDGCVKIYTSRVDSVASETGKLLSGLADSANVRDGEDGEDGDADEDGERRSKRKANRSEATLVKDFSAIKVKKLDLDFTVDPLFKKTSADFDEGGARGLLLNNLTIDRDCKIIFDASDAFAEAEEEESPRSDGQENPVQPAEERPTEEEPTTQSEVMDEQPEDVPVSEQAEDAMDVEQPETEEEKPAEPKLDEQTHHDNKVEVSRLKAKLPSLEELMTMEISPSLRGFEFSSTDALDIPFTKQNNDVHVDNSQEIDQDPGYQQDVQQEANDDIDDLFNDIDNDDDVHQEDTQLEGFLEPADAGTDAATVKNYEMAMNPDLQADMFSYFDAAFMRNWAGPEHWKLRRPMSKLPAKDTNEQNTEEGEDAQKSKKAKKVPFEIDFLNSEDLDEATLFANDKKGSITMAVKRDSKNSTHLLPDDMHFSSRQLLHYFLKPDHSFRKRKKVVNEDEDVVIANDDINTQMEEPDAQYWAQEDEPIIDDGNLTQGDMSFAGDQTILSAVEDATFLQDAYDDINDTQTSNIYGDELITNHRLKKIKPLYVNYARTAKRVDVRRLKDNLWKTMAPPLNQSSSSLEKGTADEATEESDGLKGEHKFSEVIHNLKSEYSTRTMKDISVPFCFICLLHLANEKKLKLSNELDGTEQDLDAMGASLKDLVVVQDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7D3</accession>
    <name>A0A8H7U7D3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_005276</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TIM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7D3"/>
    <dbReference type="OrthoDB" id="436405at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.320:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2173856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="213" mass="23684" checksum="A6B074C3287DDBB2" modified="2022-01-19" version="1">MPNPMLRQAVIPVVRANLVRSQKRAFTVGRPCMATNEGRRSALISQQTAKEWKDLTTPQKVVAATKTSVNMGLIAAGVAVTGTILYYVGSELFGSQSSTHVFSNALDRVRQHEELSAILGTPIKGHGEPSRSRGRRNRRIMHQLAEDTEGREHMLMRFYVEGPDNEGTCIVNMIKGDNGKWDFKQLYVDVPGQGYPSRRIYVEGSPDLSKGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7F1</accession>
    <name>A0A8H7U7F1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Chitin synthase</fullName>
            <ecNumber evidence="2 7">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_009041</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chitin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 7"/>
    <dbReference type="EMBL" id="JAEPQZ010000021">
        <property type="protein sequence ID" value="KAG2171380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7F1"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF38">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="553"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="635"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="688"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="819"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="858"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="9">
        <location>
            <begin position="137"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2171380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="888" mass="101296" checksum="7F4A75F62237E4EA" modified="2022-01-19" version="1">MESAYSPYASPRRQIRGSPYAQHSQYTINPHDFERITQSMSQNIYPHPTSLYPPVQGSPAPAMGSPYSLRYASREPLYPPVDTHVEQEQHFVEPPPAQMSMMPSLANLSSYIPIAFNLSSIYPKMTSTEPSNLKRQRTVREVELVQGNLVLDCPVPTSLAQTNARRDFEFSHMRYSAVTCDPDSFSESQFTLRPKLQGRETELFICMTMYNEDETLFCRTLHGVMKNIAHLCSRSRSKTWDFNGWKKVVVCIVADGRKKCDPRVLNVLECLGVYQEGVAKNMVNDKPVQAHLYEYTTQVSMDPEMRIKGADKGVVPVQILFCLKEHNAKKINSHRWFFNAFGPVLQPNVCVLLDVGTRPGNTSIYHLWKAFDNDQKVGGACGEICTMTGSFGVNLLNPLVACQNFEYKMSNILDKPLESVFGYISVLPGAFSAYRYAALQNDHNGQGPLQKYFMGETQQDGNSDIFTANMYLAEDRILCFELVARKHQRWLLRYVKSAFGETDCPDQLAELISQRRRWLNGSFFAAVYSLWHFPQIWSTDHSGLRKAALSVEFFYNLVSLCFSWFALANILALQANFYLTFYFVSKSFSSPEVDPFGGNWGKHIFQFLHYLYIFLLISSFICSMGNRPQGSRWMFIFSVLAFAVIMSYMLFAGTWLSILSISAAFSAADWGYIDNFERFNRLMNTPGFGTFMVSLLSTYGLYFISSVMYFDPWHLVTSFVQYMLLMPSYVNVLNCYAFCNTHDVSWGTKGDNTMQTDLGVAKHINNKEGKQTVELEMYTETVDIDAAYEEALFKLQHKPVLHRESRTAKTKQDDYYRGFRTRLVLTWIACNAFIVAVFTQDDFEVIIHSGPGALGTAYTSFILWTVAFMAAFRFIGSSLYLILRICGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U7K0</accession>
    <name>A0A8H7U7K0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 11">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1 11">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 11">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_004299</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1 11"/>
    <dbReference type="EMBL" id="JAEPQZ010000013">
        <property type="protein sequence ID" value="KAG2174276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U7K0"/>
    <dbReference type="OrthoDB" id="337870at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000001">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054608">
        <property type="entry name" value="SYY-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22421">
        <property type="entry name" value="SYY_C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="12">
        <location>
            <begin position="406"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2174276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="473" mass="52582" checksum="78CDC9ABC4425122" modified="2022-01-19" version="1">MYAAFVLIRINISPDLEKHSENKTAIYSGVDPTAKSLHLGNLVTLMGLLHFHIQGHQAIALIGGATGSIGDPSGRQSERMPLSPETLQTNVDHITRQIHRFFANGSSYAMKRGWLTAGLEQCTPKVVNNEEWLKGMGALEFLGDVGRYARVSQMLARESVNYHSVKARLNTDHGISFTEFAYQLLQAYDFWYLYHHHSCRVQVIECGISLGYMTEAKSLFQLGGSDQWGNITAGIDMIHKKKPNSSSLFVPSNDDETRKLEDRAFGITIPLLLTSKGEKFGKSAGNAVWLDETMTSLFDFYQFFVNTSDDDVERYLPLFTLLNNEEISAVMKEHKQTPEKRIAQHKLAEEAIELVHGPESVSKAKTATKVLFGGDLHEIGADSIIQAFAHDNSRMRIIDKEKVANAGLDAVAVLAGATKSKSETQKLIKAGGVYLNNEKISDPRFKIQESDLLSGKLCVLRIGKTSYHLLHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8D7</accession>
    <name>A0A8H7U8D7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8D7"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948:SF10">
        <property type="entry name" value="MRJ, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="24"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="115" mass="13547" checksum="C197F2B6BB94F228" modified="2022-01-19" version="1">MSRAGQPQPSFIGFLLSYSIFQMDYYSILEVDSSANEHEIKKSYRKLALRWHPDKNSSPEAAEKVISRRYGMRMNLTNTWMMHAKFHILTRALNDNLIAKRTKYCRTVGFFETMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U8G0</accession>
    <name>A0A8H7U8G0_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b mRNA-processing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_004584</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Essential for the assembly of ubiquinol-cytochrome c reductase. It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CBP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000015">
        <property type="protein sequence ID" value="KAG2173210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U8G0"/>
    <dbReference type="OrthoDB" id="5576752at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012420">
        <property type="entry name" value="Cbp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28202">
        <property type="entry name" value="ASSEMBLY FACTOR CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28202:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07960">
        <property type="entry name" value="CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2173210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="78" mass="8962" checksum="D22BC946CF8CBFD4" modified="2022-01-19" version="1" fragment="single">MDKAVKAVIWGTVIIGSGYGLMKFTVPTESQMRERLTPELRREADRLRNSNVDKREALAERIRDAATTEKPIWDTRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9F6</accession>
    <name>A0A8H7U9F6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_007903</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Positive regulator of amino acid starvation-induced autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SCOC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000009">
        <property type="protein sequence ID" value="KAG2177246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9F6"/>
    <dbReference type="OrthoDB" id="2376684at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019357">
        <property type="entry name" value="SCOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614:SF0">
        <property type="entry name" value="GEO08385P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614">
        <property type="entry name" value="SHORT COILED COIL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10224">
        <property type="entry name" value="DUF2205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2177246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="92" mass="9843" checksum="92AB8F000D1F0F75" modified="2022-01-19" version="1">MSESTWDEEDSSEREHLISKVLELQGSLRALIARVDSAQGEYQSLSQENQMLQKYINNSLTSTAVFGATGGAIGNLNTEGTTTKSNSTNGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9U2</accession>
    <name>A0A8H7U9U2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peroxisomal-coenzyme A synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">INT43_005127</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9U2"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05926">
        <property type="entry name" value="FACL_fum10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045310">
        <property type="entry name" value="Pcs60-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="11"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="423"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG2173707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="57404" checksum="E303E58F8EAE3789" modified="2022-01-19" version="1">MSTLFSIFERNNNDRTAVVIPSSTPDPTELSFSQLLRAIDDFSVKLASVLPASTFQPGNVLSLAYPNSLEFTIAFLATGFLRLTSAPLNAAYTEDEFKFYLDDSKSQAIIVPQGATEQNSPVVRAAKSFGVAVVEIQWSNKQLEVQLTVPGKDKSKGGFNTRNIRPQPDDVALLLHTSGTTGRPKGVPLSHLNIATTMQNIINTYDLSPSDRTYLVMPLFHVHGLVCGLLATLLSGGSAVIPQKFSAQVFWKDFVETQCNWYTAVPTMHQILLLHPPQHIPKIRFIRSCSSSLAPPTFHALEETFKAPVLEAYAMTEAAHQMTSNPLPPAARKPGSVGLGQGVEIAILDKDGKHVEEGEVCIKGANVTKGYLNNPSANKSSFTADGWFRTGDQGKKDKDGYLILTGRIKELINRGGEKISPLEIDGILLAHPKVGEAVCFGVEDEMYGQEVHAAVVLKKEYQNEDHKQIEKEVQEFAAKKLAKFKVPKRVYVVTEMQKTATGKVSRVKMSEAANKKLKSPKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7U9V1</accession>
    <name>A0A8H7U9V1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_005157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000014">
        <property type="protein sequence ID" value="KAG2173737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7U9V1"/>
    <dbReference type="OrthoDB" id="10405190at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2173737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="269" mass="30460" checksum="3E7D2F5955EC5972" modified="2022-01-19" version="1">MLDRFAVWDSAYQSWHFEESRAILLDVNGTALGVTDLETMRQLMTHTLSMEGDLCKMEKFQLLFQSSAACLEVFDVVKSLAPCQIFPEVPSKAGICKTKAADKRSTSSIVQPSSEQQQMQPALATNAHASQMQQPKREYEQQKHEPEQRQPSHPLSSGGMLPLYTQGQIQHHQQLHQALANNENGAFPSMHPLMSTEPSVSTQPLTTARSHQQQEKQVPLSENEMLSRELPVQLPVIDRTRIHRILHDPLFPAIVRISFDFCKLPIFYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UA46</accession>
    <name>A0A8H7UA46_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_004960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UA46"/>
    <dbReference type="OrthoDB" id="4215089at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2172418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="214" mass="24599" checksum="0AF9133544043F22" modified="2022-01-19" version="1">MDEAFRYVVLGEYKYVLLSGNNLEIHNGHYLNGTVFEENELESAEKEGLFKLQDNLVCTIDVDQENDFQARDLTPFTPSSFVSTDGIPILTSKASFCIKLFNEPGEAIEFDDKLVFRSNIFTQGMTFKFEDEVYIQSLGEDDYRYLSHDDNHVYFSDDKPVDSNVWFVQGEHPGLFNLYDGKNYYSTRFVKASYGEVVKVDSKDEATVFQILSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UAA3</accession>
    <name>A0A8H7UAA3_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000017">
        <property type="protein sequence ID" value="KAG2172299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UAA3"/>
    <dbReference type="OrthoDB" id="4383396at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034504049" evidence="1">
        <location>
            <begin position="19"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2172299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="84" mass="9047" checksum="A2E1D37A0E1BD7BE" modified="2022-01-19" version="1">MKFATVLAVFLAMAYVNAAVVDVTEVPKYIAIEKRDCGAAGSCVGLGGQELCNDRCKRCTGPTGKYHRGACCGWFDQSCCCYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UBZ7</accession>
    <name>A0A8H7UBZ7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_003778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UBZ7"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668:SF1">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G01940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2179991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="243" mass="26788" checksum="A1B58941CCD6715B" modified="2022-01-19" version="1">MSTAKACCQIPPVVSNYQAVGTIENLGDLPVYTVGPKTSKKAVFVIYDIFGLHPNTKQFCDVLANNCGYQVVMPDFFRGKPATPDILGKRDELMAWLQKVGTIDVLEPSIQRVKEHLIAQGVEKTGVVGFCWGAKIAIQLSARDKYYSAASLIHPSFFANEDAEGAQAPLLLIPTKDEADLTEFMQILSKKPFGDKCEHHRFDDVHHGFAAARGNWEEGSLDKQRATEAIQLTANFFAKNVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UC91</accession>
    <name>A0A8H7UC91_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">KICSTOR complex protein SZT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_004080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="43547at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033228">
        <property type="entry name" value="SZT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14918">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN SZT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14918:SF3">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN SZT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1766"/>
            <end position="1788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1811"/>
            <end position="1837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1951"/>
            <end position="1973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2203"/>
            <end position="2250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2203"/>
            <end position="2212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2213"/>
            <end position="2231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2180291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2324" mass="263740" checksum="F6E2106DFAD728A2" modified="2022-01-19" version="1">MDQDISIHIPSTDTNNELPTTDVPAKTSEASTAMQVLDAKIAICLVQFSRMRTRNEYHQWLLRHIGVPLSVKTYSNIKILYLSDDPEKIWSKNPTKSSDKMDKSASAQEHEPSMASPSLDGQKPVYFDPNLYMLSPHTHILSVAGEYRMVYMLDMSASLATLDPATGAVLISQVLETLENCLEGISKPFSFKTATGVVVDIRPKIRISVIAECSQFASNINIIPLLSDHPTMKVFLQNVVINRQNISQVLNRLRCEFNDFQREYVSFRKHLSRKRNKFDYDLDVSTEHTVRHDESLINDRSPKETNSPAEIDSARSEGQSVNAPSVMPDVQDEKGAEQNSFYVKSASNKNESSNDVEKKHTAPIKGSSQSQNMKEVWGLGRTGANLTYLLYACHLALKLLPQDGRPSVILITDGIMKSSLQDESIIRLFVEDDITCSIIQVGSGQKFAATANFGFVPDDDILHYVTETTGGHFILAKDCRPIKHDVNSPTTSPSVPDNVDSPEVQANFEDSYFAESHLAQQLSSKLTDLTHPVVRYHVNVDPQLPNFYHHHLIFHERLIRKRRSDSKKHQSTRSTASWPKGSKEANELSIDHRDRQEISVHRNFPWDPQSRQPEPDSRLLKYHEYALPTEFSHIVAARTRQGFVIRSINISSASREGRRHRSEDTAGISKEHIQLLMTLEWQPNVTVEYRIHASYFPTAVGALVTSNFLSESVSPSSSSPLSIPIEGKNVAMTGGIFSRTRAPRAEIYVRAHTAYAHMLQNWDVFTRRMQMLGVVTGSVAPGDARAAPMYAKLGRLRQTLIQIRELDEILRGIATFNARQLSSLNVRQHNRAFQSEQQFNRQHQYEVYVNNFKEFWESVNKHDLRYQIRCFYDHGSVDFLISKISPYMSPKLTSSYNQDYINNVETEINMGVEKMKSVLAAWSTFVGSDGTYVKLIHRSNSVQTPIENPRSPRYLGVQASDSPAISLTSSSASFCEIRLWREIGCLVTLHAVYFNVDVGARQDILRDLEALIQSANDADGVGSYVICKRPLSTLLMRDAEHLSDFDMESYTQNALMPLQQGEKFSEDHWYMPSSLWLNGQYIVRNHMRHMTWSWNTSNQHDEYHREHKMMPLADLAFQFLCHARRDQGYQLVLPRPDRTHFYKEHLTGKANKQACAIQYFIWKDASSGAITTELWMEPADTPSLEDQYAYVKEDTFEFDRTCLSQLVTFDQIHAVGRHLGVAQILEEKVDRAGDESQAEDTPMRIMSLSTIFDLAATLPLGSAMISMYTCPRFLNEKTSRCSSPGSWCSGATTPEQILSPADDLAASVHLEETPALGAKARPVARPAVPPSGATPKTKLQITTNVKSETFTNYRDPFSYCLQQYSVELSKLDDTNQDYVLLHVSLETSIAKEIKSEILLDHHYDSQVFWSKIKSAISIPANEPCIESSLVFVESLCDMRCFVHILNPRSFIVILVVKLPAVIRGLLGYQDSGKRAESRLREHYDMQLLQATVDKRLKSFKETNYVPVLMFECVRQKPLRPDSDTQQATPTLQDDSFKMEGLLQNALELTVTRIEPSEQLEDVLGIRPEVYNGRFSTSLSTPSNHSYQLIRRIDQIYAMSFVKSIYACMLQNRVIAEQDMERLTKMLREDHIKVDITEFLNSRVLLSNHVEDSEENEYDIQHRFLSVLNHYFEPVETMQSHSSNIYYYRPPMTYLTRKRSHRRMSSTSSLHMPELKTANSYSEQPLLIRLECIYRKQADAELPEGPEPLIEQTIPISEFPTNYQSLNTSTEKFDHNPHGIGSEQSPVASRDSTRAELHLVCLTLPTLTDAEGLKQSADAGSPKSAKEEEEEPQDKFESWKKANISDYQKTSLIESEARLSWFLKEEVMHNLLLLPEVTELTLKYIEDQLIKKNPFVDFPTAIAVPLTFVRNNTTSMEVFLDELEQDHNGIHRFARVGNYFYVKSDCIISHSSSQTPASPAPTEPVDTNGPPTNDGDDFCHGLGISVLTAEQHLRLENETADSRHGSPSFWLILLPRQNEVQIYFYSKHHLSNRSDIVKGVKFKIQEIQEKVNRLVLLRELNETRICSNFLEISDIEPEEHPGLSDDNSDMTEDTKIAIAQLAPNTPLIKEPQPLTIQIRRFQPGQFACPLLYTRKFPLHWRIPINGAFKSISTETLRPFSVKNHTHMFVIEREGVVVYCKIYEESASHGKYLISRIKDLRTPTSSVASPFAQGSSTTSSPAAKETTTPTTPALRARSQAMETTSVPEGDSTAVKAKATENRHLVLDVYGVELPTWIENELVGMIENRLMSHVTLREMQQFLLRNPTSKLTSAVSLFMPLEHIYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UCN2</accession>
    <name>A0A8H7UCN2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phosphoglucomutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">INT43_003308</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UCN2"/>
    <dbReference type="OrthoDB" id="8300170at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05799">
        <property type="entry name" value="PGM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000035">
        <property type="entry name" value="Pgm3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745:SF1">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745">
        <property type="entry name" value="PHOSPHOMANNOMUTASE 45A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="11">
        <location>
            <begin position="49"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="12">
        <location>
            <begin position="216"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="13">
        <location>
            <begin position="331"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG2178055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="67408" checksum="843DB67284A3B1F8" modified="2022-01-19" version="1">MFEIEQYKKLVTEWLRLDQNPETRAQITALADKVEDNLPELKERLGSRIEFGTAGLRARMEAGFSRMNDLTVIQASQGLAKYLLENVQDAKNKGVVVGHDHRHHSQTFAKLTAAVFISLGFKVWFFRQLVHTPLVPYTVKKLGGAAGIMITASHNPKDDNGYKVYWENACQIIPPHDSGIAAMIEKNLEPWIWDEKLAIESPLSQDPAKEGVIENYFEELKGLSAFRFDNEASDLKFVYTAMHGVGTPYAKRSFEAFGLKPFIPVSRQVEPDPDFPTVAFPNPEEGKGALALAIECAEQNNARIIIANDPDADRLAIAEKQASGEWIVFTGNQIGTILGSATLERLKMAGEPTDKVAMLASTVSSKFLAKLAVANGFLFEETLTGFKWIGNRAQELENQGYNAVFAFEEAIGFTVGKVVRDKDGVSALGFFAEWAVQLYNRGQTAYDYLQSLYRQYGFFVTNNSYFICRNPQTIREIFFRIRYGGNAVKSSDGKYPYKLQYPENIGKYRVVGIRDLTVGYDSDTKDNTPTLPVSSSSEMITFKLDNGCVFTIRTSGTEPKIKYYCELAGSSAEEAANDLKVVVDAIGNELMEAQKNNLEFRKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UDA9</accession>
    <name>A0A8H7UDA9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">INT43_008999</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000005">
        <property type="protein sequence ID" value="KAG2181416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UDA9"/>
    <dbReference type="OrthoDB" id="2110451at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024789">
        <property type="entry name" value="APC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024790">
        <property type="entry name" value="APC4_long_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12896">
        <property type="entry name" value="ANAPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="6">
        <location>
            <begin position="32"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4 long" evidence="7">
        <location>
            <begin position="245"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG2181416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="747" mass="83835" checksum="AD6A43259E6AA7A0" modified="2022-01-19" version="1">MLDCGQSTNFPHTFPQYEEKLLTDDTEVRITLWCPNVDLLAIVHTNGLLSICRNGVHTVWNWLAEADILALAWRPDGKELAVGLQSGLVRVFDMALPYAKSTVAWRSTSQGTAICSLNWNEYHAPTEPLAILPEISSISTASSQLGVDSKNITEGELIVELPDDTNYINILAICDSEGSLHFCAFGRFFSCSLPLSSHGLQNIVVLQSTMAADLQTMSLMTKARVEDTSGAVSSDPERETLSWIMVDTGILNQKARQLANFAQKSFQIRGCLKYISLFNDALAKQYQGIAGLSSSNVRKFEQVLLDHGESNATPIVEFLGLLATGMTSEPLHYYLEQVLTEQQIRKWEKDAKAGYQSMLRIICEYIQPACDRLLCLFNELNAYSRWKECYDDLLSEVATHNAICLVGAFHGRYQELIAALKKSSESFQEFIAWARYVVQRVVDPGSTPRIACSRPMLVVDFLQNSFISDRLATFFVSQEPATFEPFLVPVNFGDQPYLPSAYPFRFKLPQSLPSDLPRPTLLDFLDKLGQTVDELFAMPAHSLQRSLKIIKTLPLCPYAGFAHQQKADHHGYINRNIAVTIIADGDSHKLFTAFVTVEKARRKLYMLNLDMQFENVEREIGAIKLARFDVQDVIVADMEIFDDIELGMILVDPAEDRKTYIATMAYTDVDYGNVDVETVRSTSATRATENLVLNRYMELKDMENVIMGTNGKQRRRILSVVDDSGKILVLEMDEGEADVEGDQDDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UEA1</accession>
    <name>A0A8H7UEA1_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_007411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UEA1"/>
    <dbReference type="OrthoDB" id="77463at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009422">
        <property type="entry name" value="Gemin6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14710">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14710:SF2">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AD" evidence="1">
        <location>
            <begin position="79"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2182481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="173" mass="19445" checksum="7FECC95AD86774EB" modified="2022-01-19" version="1">MSVADTTSESRLYGLTPEEIITACGHLVTVKLQNNDTQSGYLYVIDPFNKSVILKHETQDIAIVILRHQVVSIEANYDQPAKLMFVTNPEEEDINEDSAAMKNRKQNAIELLEASRVPIKYSTEHTVIQILDTANLYPPYVPTSIQCDNPIIRKRVSDLLQGMPSWSVSTVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFI7</accession>
    <name>A0A8H7UFI7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_003550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFI7"/>
    <dbReference type="OrthoDB" id="20507at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011666">
        <property type="entry name" value="DUF1604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF19">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07713">
        <property type="entry name" value="DUF1604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2179767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="339" mass="37907" checksum="A6AECC5E80EA615C" modified="2022-01-19" version="1" fragment="single">MAPAAVAFRMSQYNRQKTGVNRTQDDADDDPSSDSFILFGTEFPEPTEKERRQGIEDPGKFQPVWNQQVTDERGRRRFHGAFTGGFSAGYYNSVGSKEGWQPSTFVSSRSTRQEKKSGARPEDFMDEEDLEEIANARKLVATEEFDLIGGTERDLAKRKELENRAETEGGLLGAQAFQDFIVPSKDPIGVKLLRRMGWKPGQGVGARISAAKRRKLVMGGSESESEEELDENISFAPRDSAIIVFAQKRDTFGLGFDPYRNVPDISVIKRSREERSTASSTGKGTDYNKTGFGIGVLDDDDDDDVYTNFSNTGYSHELNDDYDIEERITMGRRPKTAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UFQ8</accession>
    <name>A0A8H7UFQ8_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">INT43_003476</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">WA0000067209</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 21">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UFQ8"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="16 21" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="13 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10 23" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034171426" description="non-specific serine/threonine protein kinase" evidence="23">
        <location>
            <begin position="21"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="25">
        <location>
            <begin position="635"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="967"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="422"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="729"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="22">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="810"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="22">
        <location>
            <begin position="838"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="862"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="996"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAG2178223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1243" mass="136078" checksum="72520CB16EBA8E79" modified="2022-01-19" version="1">MKSPIALLLLIASCFSSICAQRQVCELYPLGNGLDDTPNILQAFDTCGVNGTVVFTNNTFSINTVLNTTNLNDCHIHIYGTLLWSTNITYWTSLRFPILFESLSTGWLLGGKNVEVHGYGYGTIDGQGQVWYDWNKNKTNKPGRPMALTVYNADNLVIRGLRIVQAQFWSMLISQSKNIVVTDMFINNVSNSTSTTVNTDGLDIWRSDNVTIQRWNVTCFDDAIAIKGNSSNVYVSDINAYRTTGFAIGSIGQYANYPEYVTNVTMERCTLRRGLSYGAFVKTWSGVTSGTPPNGGGGGQGHVQNVLFKDMTLECSAPIVVTQCTYYALKGDPHSCDTSKLKITNVTWQNIYDVSLMQKTNHDKADEQTSVSDREPQRLPSVSDNIRLFNGGRQPSIKRTATLSDQYRSQGDAPVLTKTINLSTYREPSSKTTVPNIPRKTISSDAKPARDTESVAPTIHKPPLAPRPSIRTASPTMKSAPPPPPPRPQISQEYSSKSSIEKAAKSPTPAGTPPYPARPTTPSVPKRTITPYSPTPKPQHIYSTNRTINGDHKGMQSNTALDGDAHPRLNSSDRSNWSAPTMSSVSNVAATTTSVLKGTFGKLVNGVNDFIVTAQNSGSGSAAANSTAAPSKNLISSPYNLMHITHVGFNQKTGEFTGLPKEWQILLNQSGITKREQEANPQAVLDAITFYKETRDDLDDEVWQKFELAQSQHPPRLPNPSLISQNRISTVQGSNSRPPPLPQRRLTRPRLVVVQSDQLSNASSPEEKLEANSKPPPVPSRPNASGSKPITGRVENGFAETDTENVPPRSIKDIRKQLEQKAAESSSTITTPQKKTKPGPPPKPPLSSKPTIAPKPRLNDVPVNNSKPLNNTTEKPPRASSFVSSRPVAPPRNKSSKIEKAEEVENDDVSSIYIAPTAAPLDPALDIAAAAPIRRREHKRAKDAANDAKLIENLRAICTDADPTKLYRNMVKVGQGASGGVFTAHSVDTNMSVAIKQMNLEKQLKKDLIINEILVMRESAHKNIVNYIDAFLHGGDLWVVMEYMEGGSLTDIVTTNMMTEGQIAAVCKETLEGIAHLHAKDIIHRDIKSDNVLLGINGEVKLTDFGFCARLNDEDAKRRTMVGTPYWMAPEVVTRKEYGPKIDIWSLGIMTIEMIEGEPPYLHESPLRALYLIATNGTPELQSPNALSKLCRDFLAKALEVDADLRPTAEELLQHPFLAKADKLKALSPLIKASLATRKNAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UGD3</accession>
    <name>A0A8H7UGD3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GDP-fucose protein O-fucosyltransferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">INT43_003492</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">WA0000067209</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the glycosyltransferase 68 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000008">
        <property type="protein sequence ID" value="KAG2178239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UGD3"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046922">
        <property type="term" value="F:peptide-O-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045130">
        <property type="entry name" value="OFUT2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398:SF0">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG2178239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="474" mass="54744" checksum="CAE5FDDBF6ED59ED" modified="2022-01-19" version="1">MASLRRMIIFPAFACFCLLGYLVIWINTSAAPYEALDQHISNNKPTTNYDVEETSTEEKYLAFFTHSGLQNQLNEVENAILLAWFLNRTLIMPRALFGQPFGWMPFDRLLLEHQLRDDSESQVQMCLDHDAELDLLENDCPDPSKYTMLAFDDIFDLEWAKKHVRIINRENMTYEWLEEKLDIRRAGEMHLPNGSYVDGDILYFKDETRYHWRIFDMIQEGDRKGKYAESLDVREMRHVPQKLIHLGSVFGSGKILIRRPEHLEFWRKLQRSIIYRHPVVTKVAENFLASLNGPGSFIGVHVRSGDGFFIKALPRNMQKIMSQIKTAITKHTDIPSLQKQLEIIPKDPTLAQCLELAKSHNITMVYLATDAREPSTNPDIAVLYATFPCTFSIDDFKEPVNQPGWDALSNVTNPRDGRNMMKYLIPMVDATIASRGRLFVGTDSSTFSGYISRLHDVFWTEQQAATLIGYRNQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHD9</accession>
    <name>A0A8H7UHD9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_003720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2179933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHD9"/>
    <dbReference type="OrthoDB" id="5529571at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013262">
        <property type="entry name" value="OMP_MIM1/TOM13_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08219">
        <property type="entry name" value="TOM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2179933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14217" checksum="8F0AD8BE07F0E6FB" modified="2022-01-19" version="1">MANVTDITVTESELDDEGFRSQTVVMRSEPWWRHPTLLFVLKSTAINFLLPFINGVMLGFGEIAANELAFRYGWFGLSRATSTATLGLRGTVPASATATYKSVAEKEIAAMQKTKDSQQLERSRQVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHJ6</accession>
    <name>A0A8H7UHJ6_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2181972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHJ6"/>
    <dbReference type="OrthoDB" id="2449173at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2181972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="164" mass="18485" checksum="7911A647576EA2F8" modified="2022-01-19" version="1">MMIDINSHQKPSCADIAQKIVANTPSADDNAAKSALAIFHQRRIPVNSTTDYIANYCVQFVIRSDYTSSFLSECCIARLQVIDANPTKPLDPNFPSDKLDDVKQIFAKRVANIVVNTKHDVVSELRQRRTNKVEKGKKVKRQQKKTKAEPSGRNTRLIGEDEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHM2</accession>
    <name>A0A8H7UHM2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Membrane anchor Opy2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_002609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UHM2"/>
    <dbReference type="OrthoDB" id="2284384at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2186171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="46893" checksum="221B4E9CA019C58F" modified="2022-01-19" version="1">MSKHITTAAASLTQSGKVQLASDSLSVSKSTPSVTATTKLSLAPSATPDNCQPSGCQAQCTPACSEDQVCSLTTMQRCGMCPPSQCVNKSTLDLPSSKSSSPQLSSSPSSSTPLIVGLTVGLGGGFLLLLALFLCWRRKTRQKAEHQNWTLPTTTSDLTGNQATLTTNYVSTQLGSDRHKENFELKTDDPGTHDSASNSSDYNEKSVPPTVVTTPVSAAHTMPATTDTSISRSLSLKAKTSVAASGTIARSSSMRVTRNEMNREKKRLSDNPFDDLDDESNIVMRRAVSVRKNQRYPKREDESETADIADQRPRSALVTGHDRNSVASIYSATPAIQVMRAKPTIVRVDSLKGRDGKLSRKGTQRSDAASSQDSKSGNSSPSLETPGTQQHLPSSTLSNEPISKAVNNSQNVENINDNDHEHDQHSNEDDDQQALNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UHT2</accession>
    <name>A0A8H7UHT2_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">INT43_006596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000003">
        <property type="protein sequence ID" value="KAG2183590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1170"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1355"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1460"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="545"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1365"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1464"/>
            <end position="1490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG2183590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1490" mass="163781" checksum="4B21586C515F9084" modified="2022-01-19" version="1">MLAGETGITSDEWSFELESPYIPALELPYSVIACICKHLPTQGDRQRACLIHPIWSPAATDSLWKEPVFSNAAAFQGFYKTVHVFKRLALRVHTLNIIHDSNRNASNTIKLSSLPQHNLRESTLAKPEVVIALTRLCENVQSLKIYGWHIRAGHLERLGTALHDLKHLTIIGSNEALMSASSSFRTLLTRLATLKLDGVTNINAGFVDLLERRCQQLETLQLGVQDLGPDGFEALTLGKLLVKELILTDCSPLEDSHILELAIAFPMLESLVIIDAEKLTGEALVNVFEHCRHLRKLDIRNNSQKIASSPAKAQSGRKELKTFIKSEDLRELTIHGVNLDTITVQTTLYGHHNLHRLWLQTCHELCDDDLRLICQSSHCLEYVKVVDCPGLTGRALSTMVKSHEIKAISVQLIKCGIITTQHVKQFCQAVLGCSSKKLIISQDKGSIPPDYAGFAGELIDTQEPVYIFDKQALNSLAQSHISDGNDDGENLISQRTYTLDRKQVAMVAEHLGISSQQLRAAISKVLQNATQSKKFGKGVTAPQRISISPSEGESSPSKSNIPPTFKASEQKDATAISEPAINTKISNGWASPKVANNWPSPKPFNNWSASIGSSKNSPDVRIGAHSPDDSWLETTARKSSNVPIESEPTAAISPPPASTEQKIVFKYQPLVENSGRNVEVEDEKPAGKITVGKRSETPPKAAEPSSAIQLGGWGVSSPTWNDNFGQTAISDEGSNWDATAVERMTWQPAEIVTAPVASKSAKKKGARLYLPASSEHDGWGAPPEERVAWDDDGKQGFAHDIIQSQHQTTFWKMEGGVWKKLSAGEQREKERKDAAMEDFPMASPSGNEKSALASPPITRHILNPSSHQILDNDLPLKSSREEVDVDAHVLSDDNEDDFTDSDDGVVIKTGADDGLAPSPSRAAVLANIMDEETVLDYNESMFAELSKDPDSPPSHPGNPQWVAYEQWKKSQLQSTAIEHPEGSQAVDIPVDDGGWDDLPAATSNQPEVNGGWATEKVWDTSSPTPPIASYKLIDIIDDFNERISSLSTQSRTTSDIKWEGFESSMFSDHDNEANDQFRQLAEDKHDATVQYIKAQAESRQIAREDIIRQTENDLNSSSFTAQFESQESKFATDINADQYDANRADDDWVSSTTSEAGYNMSGLGISNKVSRRARNRESRARASARHPMRPEKMAGQWGLFPINGSNVDDSIDNPLQSPLESGHRKSDAAEILDEDERTFTHGQTKDEMHQEYDLLNTSNGSFIGSDHNDEFNYKLDTPVEPDMRRNYVSSSTADLWDEPDKLTEENLVNMDNVLSATPVLEPSGQNAHTKQYSRDFFDDLMGETANSYVAPLSAGKEAMPASTDQATTTPQSPRQQSPSPQSPSPQAATIPKGNANVTILSVKIETVDAGTQPLVIKEADDPKQAIHDFCVKYGMTEYETKIVDVTLPRYKEKMAKRVLGRAARNNNSPGQSTASPTLANNTSGSMESLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UID5</accession>
    <name>A0A8H7UID5_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">INT43_003978</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">WA0000067209</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000006">
        <property type="protein sequence ID" value="KAG2180189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UID5"/>
    <dbReference type="OrthoDB" id="10255539at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03273">
        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000278">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000385">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027120">
        <property type="entry name" value="Smc2_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="520"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1168"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="246"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="416"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="682"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="746"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG2180189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="1204" mass="136821" checksum="DDFA40C618549CAC" modified="2022-01-19" version="1">MFVEELIIEGFKSYVSRTHVTGWDPEFNAITGLNGSGKSNILDAICFVLGITNLSQVRASTLQDLIYKRGQAGVTKASVTIVFNNEDRAKSPVGFEAYKQLTVTRQVLMGGRTKYIVNGHNAQQQTVQNLFQSVQLNINNPHFLIMQGRITKVLNMKPAEILSMIEEAAGTKMFEDRKAKAFATMAKKEKKVEEINKILQEDIMPKLDKLRGEKRTYLDYQKNESEMERLNRLVVAAEYDRHAKKLDRSNADNDERKAKLDELQRLVEERNTEIAAIEDERHISTVKKQEQSEGGKNSNLEAAVQEAATSLVRLKTQVDLKNASIIDEEKNLSALQSTYKENDQAQAERKTQFDKLNALFGPLKQEFDRKTKEMQKTSELVQALTTGVSAQEGQENGYMEQLQDAKNTASRASTIEDQARLKIKHLEKDLEDKEAQANKTERQNKGLQNEIAAGLKAKSDLTRQLQSLKWDANSETQLLQQQKDTQRTISDLKDKAENLSRRLSNLDFVYTNPTPTFDRSKVKGLVAELITLDKSRFDSSTALEICAGGRLYNVVVENEIVGSQLLDKGQLRRRWTLIPLNKIQAFKASAERVATAQRMAPGKVELALTLVGYDKQVQTAMEWVFGNTLICKDAESAKRVTFDKNVRMKSVTVDGDVYDPFGTLSGGSKPNSAGILVKVQELNTIRQEIKQHQSILLNIEQELTNSKRIIMDYNQRKKMLDLKTHEMHLLEEQLRQSTHSQLVAQVAAIKEELQTQEKSIVNARRQRKEALEECERIEQEMTEFNRDKKSKLKEMQQKIASLKADIAKDSAKIKNMQRDVQTLQMEIEQTDTDANAARTEIAQLQETIEEYKKECSTANTEMQKLTLRHNELKAELQTHQAKLTEINKELERLDSEHKKIMEEVTEANLELQKLTHEYEKYQKEQNNSQQILRDLEHNHDWIVDQKSLFGQPDTPYDYRDVNLADAKKTLQQLVDKHEAMRKKINVKVMNMIDNVEKKEAGLKQMLITVQKDKQKIEDTIVSLDNYKKEALAATWEKVNKDFGDIFGELLAGNTAKLQPPEGKTISDGLEVKVCLGGVWKQSLTELSGGQRSLIALSLILSLLQFKPAPMYILDEVDAALDLSHTQNIGHLLRSRFKGSQFIVVSLKDGMFNNANVLFKTRFRDGTSIVERTSNRQSNKENETTSSPANRSKRGRDGARATARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UJH7</accession>
    <name>A0A8H7UJH7_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal silencing factor RsfS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">INT43_007020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UJH7"/>
    <dbReference type="OrthoDB" id="21330at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="IOJAP SUPERFAMILY ORTHOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043:SF0">
        <property type="entry name" value="MITOCHONDRIAL ASSEMBLY OF RIBOSOMAL LARGE SUBUNIT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02410">
        <property type="entry name" value="RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG2182093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31433" checksum="DD4A14FCBB575028" modified="2022-01-19" version="1">MFLLRRSALNLKAVITPVRPSTKLSQHLTFSRIPANLVAPLPSRRWLTSGTKDSKESLVEHETEEEKLSPEDLAAFEAELSSSSEKDEADDQDWFVDADYEQDNAGLHQSDFIPLWQRRATGEVAASTAAANMIKDKKVKLSSVLALLEESKAENVSVIDMRSKCDWTDFMIVAESSRGERFLNSIADELVGVLGKAQKSDPSMSSLPKPNVEGQKEGSDWLLVDAGPFIIHLFTPEARVQYDLENLWANVPDDPLLRVESKGLNADQLKDEVEQSIGKPVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UKC1</accession>
    <name>A0A8H7UKC1_MORIS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_006990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000004">
        <property type="protein sequence ID" value="KAG2182064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UKC1"/>
    <dbReference type="OrthoDB" id="29061at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2182064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="76" mass="8270" checksum="96BF571B4D4C085B" modified="2022-01-19" version="1">MTEPSAPQQLKAQELSVDDLITHIVSTTSIKDISATLLPLLRAIPSATFLSPSESGLDPLEQLEPDSHSLGYLYFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7ULP9</accession>
    <name>A0A8H7ULP9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1479-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">INT43_002820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">WA0000067209</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2186382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7ULP9"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG2186382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="47704" checksum="A8B639889A1CA380" modified="2022-01-19" version="1">MVVHQNVPIWDQKAAIADVKNTFVGKEDALKQSYDRLVQELLKKKGEIQAAGPAYIPTCNYQDIVSNNGKIPDDLAKRVHETGCFIIKGVIDPEEVLARKKEIQEYWYGNEERTGNKVRAVQNAPGLIKLRQQPDLVKCMAAANSLWHDPSGETEWVADKPMMYIDGCRIRLAGQPGGMPAHVDSGGIDRWHHQAYRKCYQKIWQGKWEEHDAWDVTERVNLHLQCNKLFRAFQGWVAMSEAGVDKGTIRLCPAIKEQTAYYLLKTLVDPEMTEKKWPQVHGIPLREDLYPLINECLVTIPDVQPGDYVLWHCDLGHSVEYTHNGDKDSSVAYIPASPMCPLNASYLAEQRTTYLEGAKGPDFQIRDHEKGLETTYEPIPKEDDLSDLGKQLMGFAPYTVGPNDDEKTKNIVQKCNQILGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UN09</accession>
    <name>A0A8H7UN09_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Transaldolase</fullName>
            <ecNumber evidence="3 9">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_002188</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="3 9"/>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UN09"/>
    <dbReference type="OrthoDB" id="2015515at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000088">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00492">
        <property type="entry name" value="Transaldolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009001">
        <property type="entry name" value="PRK12346.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2185753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="323" mass="36117" checksum="1521FCDEE17A948D" modified="2022-01-19" version="1">MSVLEQIKQYTTIVADSGDFESIAEYKPQDATTNPSLILAASQKENYAKLIDEALQFGKQKGGSLDEQTEWALDKLLVNFGTEILKIVPGRVSTEVDARLSFDKDATIEKALRLISLYKDAGVDKKRILIKIASTWEGIQAAHILETKHDIHCNLTLLFGFPQAVACAEAGVTLISPFVGRILDWYKASTGKTYSATEDPGVVSVSKIYKYYKAHGYKTIVMGASFRNTGEIEELAGCDFLTISPNLLADLAKDNKKIERKLSPEQAQNDVNEKVSFFSNEKKFRWEMNEDPMATEKLSEGIRKFAADAVKLEKTFRERLQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7UN81</accession>
    <name>A0A8H7UN81_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ArsA/GET3 Anion-transporting ATPase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">INT43_002401</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the arsA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000001">
        <property type="protein sequence ID" value="KAG2185963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7UN81"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000235">
        <property type="entry name" value="ATPase ASNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="9">
        <location>
            <begin position="26"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG2185963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="332" mass="37379" checksum="ED4D66489BAF0EDF" modified="2022-01-19" version="1">MSDLSDDDFQPLDPSLKNILDQQSLHWIFVGGKGGVGKTTTSCSLAVQLSKVRESVLLISTDPAHNLSDAFGQKFSKEATLINGFDNLFAMEIDPTSSIQEMIEQSDQNNAMGSMFQDLAFAIPGVDEAMGFAEVMKQVKTMQYSVIIFDTAPTGHTLRFLSFPTVLEKALAKVSTLSGRFGPMFQQMSGMMGMNANQEDMFGKLEEMRSIITEVNNQFKDPNTTTFVCVCISEFLSLYETERMIQELTSYKIDTHNIVVNQLLFPKEGSNCEHCGVRHKMQQKYLDQIYDLYEDFHIIRMPLLTKEVRGTEDIKEFSKMLVEPFQPAKDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDK3</accession>
    <name>A0A8H7PDK3_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="10">FBP aldolase</shortName>
            <ecNumber evidence="5 10">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">INT43_001417</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 10"/>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDK3"/>
    <dbReference type="OrthoDB" id="35652at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00946">
        <property type="entry name" value="FBP_aldolase_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000013">
        <property type="entry name" value="Class II fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006628">
        <property type="entry name" value="PRK09197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559:SF0">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG2171941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="358" mass="39284" checksum="5CA9A3B52242C3F5" modified="2022-01-19" version="1">MGLLDIVPAGVVTGDNLRKLLQYAKKEKFAIPAINCTSTSTVNAALEAARDIGSPIIIQFSNGGAAYFAGKGLSNDGQKASILGAVAGAQYVRTVAKAYGIPVITHSDHCAKKLLPWFDGMVEADEAYFKQHGEPLFSSHMLDLSEEPKEENIEVCLKYLKRLAPMGCALEMEIGITGGEEDGVNNENVDNAALYTQPEDIWDIYKAFSEITDLFSIAAAFGNVHGVYAPGNVRLHPELLGKHQAYVKEQLKTDDDLPVFFVFHGGSGSTQQDINTAVSHGVVKMNVDTDTQWAYLVGFRDYFNAKKEYLATQVGNPEGANKPNKKYYDPRVFVREGEKTMIKRIQEACEHLGNVKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PDX9</accession>
    <name>A0A8H7PDX9_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">INT43_001386</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">WA0000067209</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the C-terminal section; belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000018">
        <property type="protein sequence ID" value="KAG2171910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PDX9"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007956">
        <property type="entry name" value="PRK10675.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="12">
        <location>
            <begin position="137"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="37"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG2171910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="486" mass="54497" checksum="3F7680DB6EDDD8B1" modified="2022-01-19" version="1">MSPTPTSSHPLQDENSTKMPLGTNTEVMVEQLSILDRTSPSSTKRQSFSHHRRKSSASSTHHAMLQSRPTTQETPFYVSPNGIKSSTGEIDLAPHLAVPMRHRRHTSVDHASHIKSLPNSNTKSYSNYYDVNRNKYVLVTGGAGYIGSHTVLELLSRNYEIVVLDNLCNSNLEALKRVEKLAGRSITFHRADITVEEQLVQVFSMYKFWAVIHFASLKAVGESMKIPLDYYHNNLTGSINLMRVMQKFNVKNMVFSSSATVYGDPEYTPVGESARLGPVTNPYGKTKLFLEEMLRDQCTADPEWNVCLLRYFNPVGAHPSGLIGEHPQGIPNNLLPYVNKVIQGHLPHVQVFGEDYDTIDGTGVRDYIHVCDLASGHVAALKKLEKKPRCVAYNLGTGVGCSVLQIIKSMERVTGVHIPYKVVDRRPGDIATCTADATLANRELEWFPSRTLDEMCEDMWRWTRRNPNGYDSPMLESDEDSDEAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PF66</accession>
    <name>A0A8H7PF66_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">INT43_000177</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">WA0000067209</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAEPQZ010000016">
        <property type="protein sequence ID" value="KAG2172827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8H7PF66"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000654370">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000059">
        <property type="entry name" value="N-ethylmaleimide reductase, FMN-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG2172827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000654370"/>
        </source>
    </evidence>
    <sequence length="376" mass="41570" checksum="175548858B8D4FF9" modified="2022-01-19" version="1">MSSKGLFQPIRIGNHELKHRVVLAPLTRLRADPETHAPNEKHVQYYGQRAGNGGGLLITEATHISPMAGSWPGTPAIYTKEQIEGWKKVTKAVHDRGSIIFVQLWHVGRATHAAWLPNNAQPVSASAIAINGPDSFGIPNEVPRALETDEIQDLINDYVQAAKNGIEAGFDGVEIHGANGYIIDQFINSNTNQRTDRYGGSIENRTRLALEVVDAVVKAVGADKTAIRFSPFNDFQDMDDATPNDTWGYLVQQLQNNHPDLAYIHMVEPRFTFEDSAGSSEHNLDHFRNIWKSVFINAGGFGHDLAGAIEHAEKTGDLIAFGRYYIANPDLPYRLQQQLPLNAYNRATFYGAGPEGYTDYPTYEETQTAPETTVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8H7PFV6</accession>
    <name>A0A8H7PFV6_MORIS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">INT43_004521</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mortierella isabellina</name>
        <name type="common">Filamentous fungus</name>
        <name type="synonym">Umbelopsis isabellina</name>
        <dbReference type="NCBI Taxonomy" id="91625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Umbelopsidomycetes</taxon>
            <taxon>Umbelopsidales</taxon>
            <taxon>Umbelopsidaceae</taxon>
            <taxon>Umbelopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-12" db="EMBL/GenBank/DDBJ databases">
            <title>Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina.</title>
            <authorList>
                <person name="Muszewska A."/>
                <person name="Okrasinska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Drgas O."/>
                <person name="Orlowska M."/>
                <person name="Perlinska-Lenart U."/>
                <person name="Aleksandrzak-Piekarczyk T."/>
                <person name="Szatraj K."/>
                <person name="Zielenkiewicz U."/>
                <person name="Pilsyk S."/>
                <person name="Malc E."/>
                <person name="Mieczkowski P."/>
                <person name="Kruszewska J.S."/>
                <person name="Biernat P."/>
                <person name="Pawlowska J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">WA0000067209</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family. PalF/RIM8 subfamily.</text>
    </comment>
    <comment type=
[file cut: first 33554432 bytes kept]
[document cut: first 30750159 of 33554432 characters kept]
